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REVIEW
Thierry Lefèvre, Manuel Pan, Goran Stankovic, Soledad Ojeda, Nicolas Boudou, Emmanouil S Brilakis, George Sianos, Giuseppe Vadalà, Afredo R Galassi, Roberto Garbo, Yves Louvard, Juan Luis Gutiérrez-Chico, Carlo di Mario, David Hildick-Smith, Kambis Mashayekhi, Gerald S Werner
Knowledge in the field of bifurcation lesions and chronic total occlusions (CTOs) has progressively improved over the past 20 years. Therefore, the European Bifurcation Club and the EuroCTO Club have decided to write a joint consensus statement to share general knowledge and practical approaches in this complex field. When percutaneously treating CTOs, bifurcation lesions with relevant side branches (SBs) are found in approximately one-third of cases (35% at the proximal cap, 38% at the distal cap, and 27% within the CTO body)...
September 11, 2023: JACC. Cardiovascular Interventions
#22
JOURNAL ARTICLE
Aswin Chari, Sophie Adler, Konrad Wagstyl, Kiran Seunarine, M Zubair Tahir, Friederike Moeller, Rachel Thornton, Steward Boyd, Krishna Das, Gerald Cooray, Stuart Smith, Felice D'Arco, Torsten Baldeweg, Christin Eltze, J Helen Cross, Martin M Tisdall
AIM: To evaluate a lesion detection algorithm designed to detect focal cortical dysplasia (FCD) in children undergoing stereoelectroencephalography (SEEG) as part of their presurgical evaluation for drug-resistant epilepsy. METHOD: This was a prospective, single-arm, interventional study (Idea, Development, Exploration, Assessment, and Long-Term Follow-Up phase 1/2a). After routine SEEG planning, structural magnetic resonance imaging sequences were run through an FCD lesion detection algorithm to identify putative clusters...
August 9, 2023: Developmental Medicine and Child Neurology
#23
REVIEW
Andrii P Gryganskyi, Jacob Golan, Anna Muszewska, Alexander Idnurm, Somayeh Dolatabadi, Stephen J Mondo, Vira B Kutovenko, Volodymyr O Kutovenko, Michael T Gajdeczka, Iryna M Anishchenko, Julia Pawlowska, Ngoc Vinh Tran, Ingo Ebersberger, Kerstin Voigt, Yan Wang, Ying Chang, Teresa E Pawlowska, Joseph Heitman, Rytas Vilgalys, Gregory Bonito, Gerald L Benny, Matthew E Smith, Nicole Reynolds, Timothy Y James, Igor V Grigoriev, Joseph W Spatafora, Jason E Stajich
The first genome sequenced of a eukaryotic organism was for Saccharomyces cerevisiae , as reported in 1996, but it was more than 10 years before any of the zygomycete fungi, which are the early-diverging terrestrial fungi currently placed in the phyla Mucoromycota and Zoopagomycota , were sequenced. The genome for Rhizopus delemar was completed in 2008; currently, more than 1000 zygomycete genomes have been sequenced. Genomic data from these early-diverging terrestrial fungi revealed deep phylogenetic separation of the two major clades-primarily plant-associated saprotrophic and mycorrhizal Mucoromycota versus the primarily mycoparasitic or animal-associated parasites and commensals in the Zoopagomycota ...
July 18, 2023: Microorganisms
#24
JOURNAL ARTICLE
Elisa J Gordon, Jessica Gacki-Smith, Brianna R Kuramitsu, Max Downey, Karen B Vanterpool, Michelle J Nordstrom, Tiffany Riggleman, Carisa M Cooney, Sally Jensen, Gregory Dumanian, Scott Tintle, Macey Levan, Gerald Brandacher
UNLABELLED: Although upper extremity (UE) vascularized composite allotransplantation (VCA) aims to improve quality of life, relatively few have been performed worldwide to support evidence-based treatment and informed decision-making. METHODS: We qualitatively examined factors contributing to anticipated and actual decision-making about UE VCA and perceptions of the elements of informed consent among people with UE amputations, and UE VCA candidates, participants, and recipients through in-depth interviews...
August 2023: Transplantation Direct
#25
JOURNAL ARTICLE
Kalvin C Yu, ChinEn Ai, Molly Jung, Heather Johnson, Scott Smith, Judith LaJoie, Gerald Denny
Repeated access of peripheral intravenous (IV) devices theoretically increases the risk of bacterial exposure. PIVO™ (VelanoVascular) is a needleless, single-use device that enables blood sampling from an existing peripheral IV. The goal of this retrospective observational exploratory study was to evaluate the influence of PIVO use on rates of hospital-onset bacteremia and fungemia (HOB) by comparing HOB rates in the year before and after PIVO introduction in hospitals implementing PIVO and over similar time periods in "control" hospitals with no PIVO...
July 24, 2023: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
#26
RANDOMIZED CONTROLLED TRIAL
Steven K Grinspoon, Kathleen V Fitch, Markella V Zanni, Carl J Fichtenbaum, Triin Umbleja, Judith A Aberg, Edgar T Overton, Carlos D Malvestutto, Gerald S Bloomfield, Judith S Currier, Esteban Martinez, Jhoanna C Roa, Marissa R Diggs, Evelynne S Fulda, Kayla Paradis, Stephen D Wiviott, Borek Foldyna, Sara E Looby, Patrice Desvigne-Nickens, Beverly Alston-Smith, Jorge Leon-Cruz, Sara McCallum, Udo Hoffmann, Michael T Lu, Heather J Ribaudo, Pamela S Douglas
BACKGROUND: The risk of cardiovascular disease is increased among persons with human immunodeficiency virus (HIV) infection, so data regarding primary prevention strategies in this population are needed. METHODS: In this phase 3 trial, we randomly assigned 7769 participants with HIV infection with a low-to-moderate risk of cardiovascular disease who were receiving antiretroviral therapy to receive daily pitavastatin calcium (at a dose of 4 mg) or placebo. The primary outcome was the occurrence of a major adverse cardiovascular event, which was defined as a composite of cardiovascular death, myocardial infarction, hospitalization for unstable angina, stroke, transient ischemic attack, peripheral arterial ischemia, revascularization, or death from an undetermined cause...
August 24, 2023: New England Journal of Medicine
#27
JOURNAL ARTICLE
Gerald S Werner, David Hildick-Smith, Victoria Martin Yuste, Nicolas Boudou, Georgios Sianos, Valery Gelev, Jose Ramon Rumoroso, Andrejs Erglis, Evald Hoj Christiansen, Javier Escaned, Carlo di Mario, Luis Teruel, Alexander Bufe, Bernward Lauer, Alfredo Ruggero Galassi, Yves Louvard
BACKGROUND: Percutaneous coronary intervention (PCI) for chronic total coronary occlusions (CTO) improves clinical symptoms and quality of life. The longer-term safety of PCI compared to optimal medical therapy (OMT) remains uncertain. AIMS: We sought to evaluate the long-term safety of PCI for CTO in a randomised trial as compared to OMT. METHODS: A total of 396 patients with a symptomatic CTO were enrolled into a randomised, multicentre clinical trial comparing PCI and OMT...
July 21, 2023: EuroIntervention
#28
JOURNAL ARTICLE
Max C Downey, Jessica Gacki-Smith, Brianna Kuramitsu, Karen B Vanterpool, Michelle Nordstrom, Michelle Luken, Whitney Langlee, Tiffany Riggleman, Shannon Fichter, Withney Altema, Sally E Jensen, Gregory A Dumanian, Carisa M Cooney, Macey L Levan, Scott Tintle, Gerald Brandacher, Elisa J Gordon
OBJECTIVE: Upper extremity vascularized composite allotransplantation is an innovative treatment option for people with upper extremity amputations. Limited patient-relevant long-term outcomes data about transplant success may impede patients' informed treatment decision-making. We assessed perceptions of what constitutes upper extremity vascularized composite allotransplantation success among individuals with upper extremity amputations. METHODS: This multisite study entailed interviews and focus groups with individuals with upper extremity amputations and upper extremity vascularized composite allotransplantation candidates, participants, and recipients...
2023: SAGE Open Medicine
#29
Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres Fernandez, John C Kraft, Jing Li, Viet Q Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, P Daniel Poulson, Garrett E Casper, Mary L Vallecillo-Zúniga, Jonard Corpuz Valdoz, Marcos C Miranda, Hua Bai, Yakov Kipnis, Audrey Olshefsky, Tanu Priya, Lauren Carter, Rashmi Ravichandran, Cameron M Chow, Max R Johnson, Suna Cheng, McKaela Smith, Catherine Overed-Sayer, Donna K Finch, David Lowe, Asim K Bera, Gustavo Matute-Bello, Timothy P Birkland, Frank DiMaio, Ganesh Raghu, Jennifer R Cochran, Lance J Stewart, Melody G Campbell, Pam M Van Ry, Timothy Springer, David Baker
The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Compounds that can discriminate between the two closely related integrin proteins and other RGD integrins, stabilize specific conformational states, and have sufficient stability enabling tissue restricted administration could have considerable therapeutic utility. Existing small molecules and antibody inhibitors do not have all of these properties, and hence there is a need for new approaches...
June 12, 2023: bioRxiv
#30
JOURNAL ARTICLE
Maninder Kaur, Justin Blair, Batsal Devkota, Sierra Fortunato, Dinah Clark, Audrey Lawrence, Jiwoo Kim, Wonwook Do, Benjamin Semeo, Olivia Katz, Devanshi Mehta, Nobuko Yamamoto, Emma Schindler, Zayd Al Rawi, Nina Wallace, Jonathan J Wilde, Jennifer McCallum, Jinglan Liu, Dongbin Xu, Marie Jackson, Stefan Rentas, Ahmad Abou Tayoun, Zhang Zhe, Omar Abdul-Rahman, Bill Allen, Moris A Angula, Kwame Anyane-Yeboa, Jesús Argente, Pamela H Arn, Linlea Armstrong, Lina Basel-Salmon, Gareth Baynam, Lynne M Bird, Daniel Bruegger, Gaik-Siew Ch'ng, David Chitayat, Robin Clark, Gerald F Cox, Usha Dave, Elfrede DeBaere, Michael Field, John M Graham, Karen W Gripp, Robert Greenstein, Neerja Gupta, Randy Heidenreich, Jodi Hoffman, Robert J Hopkin, Kenneth L Jones, Marilyn C Jones, Ariana Kariminejad, Jillene Kogan, Baiba Lace, Julian Leroy, Sally Ann Lynch, Marie McDonald, Kirsten Meagher, Nancy Mendelsohn, Ieva Micule, John Moeschler, Sheela Nampoothiri, Kaoru Ohashi, Cynthia M Powell, Subhadra Ramanathan, Salmo Raskin, Elizabeth Roeder, Marlene Rio, Alan F Rope, Karan Sangha, Angela E Scheuerle, Adele Schneider, Stavit Shalev, Victoria Siu, Rosemarie Smith, Cathy Stevens, Tinatin Tkemaladze, John Toimie, Helga Toriello, Anne Turner, Patricia G Wheeler, Susan M White, Terri Young, Kathleen M Loomes, Mary Pipan, Ann Tokay Harrington, Elaine Zackai, Ramakrishnan Rajagopalan, Laura Conlin, Matthew A Deardorff, Deborah McEldrew, Juan Pie, Feliciano Ramos, Antonio Musio, Antonie D Kline, Kosuke Izumi, Sarah E Raible, Ian D Krantz
Cornelia de Lange Syndrome (CdLS) is a rare, dominantly inherited multisystem developmental disorder characterized by highly variable manifestations of growth and developmental delays, upper limb involvement, hypertrichosis, cardiac, gastrointestinal, craniofacial, and other systemic features. Pathogenic variants in genes encoding cohesin complex structural subunits and regulatory proteins (NIPBL, SMC1A, SMC3, HDAC8, and RAD21) are the major pathogenic contributors to CdLS. Heterozygous or hemizygous variants in the genes encoding these five proteins have been found to be contributory to CdLS, with variants in NIPBL accounting for the majority (>60%) of cases, and the only gene identified to date that results in the severe or classic form of CdLS when mutated...
June 28, 2023: American Journal of Medical Genetics. Part A
#31
JOURNAL ARTICLE
Karen B Vanterpool, Jessica Gacki-Smith, Max C Downey, Michelle Nordstrom, Michelle Luken, Tiffany Riggleman, Shannon Fichter, Withney Altema, Sally E Jensen, Gregory A Dumanian, Carisa M Cooney, Macey L Levan, Scott Tintle, Gerald Brandacher, Elisa J Gordon
BACKGROUND: Upper extremity vascularized composite allotransplantation is a life-enhancing reconstructive treatment option that aims to improve recipients' quality of life and maximize function. This study assessed upper extremity vascularized composite allotransplantation patient selection criteria perceptions among individuals with upper extremity limb loss. The perceptions of individuals with upper extremity limb loss on patient selection criteria may enable vascularized composite allotransplantation centers to improve criteria to avoid mismatched expectations about the posttransplant vascularized composite allotransplantation experience and outcomes...
2023: SAGE Open Medicine
#32
JOURNAL ARTICLE
Megan E Carey, Zoe A Dyson, Silvia Argimón, Louise Cerdeira, Corin Yeats, David Aanensen, Gerald Mboowa, Stephen Baker, Sofonias K Tessema, Anthony M Smith, Iruka N Okeke, Kathryn E Holt
The global response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic demonstrated the value of timely and open sharing of genomic data with standardized metadata to facilitate monitoring of the emergence and spread of new variants. Here, we make the case for the value of Salmonella Typhi ( S . Typhi) genomic data and demonstrate the utility of freely available platforms and services that support the generation, analysis, and visualization of S. Typhi genomic data on the African continent and more broadly by introducing the Africa Centres for Disease Control and Prevention's Pathogen Genomics Initiative, SEQAFRICA, Typhi Pathogenwatch, TyphiNET, and the Global Typhoid Genomics Consortium...
May 2023: Open Forum Infectious Diseases
#33
JOURNAL ARTICLE
Pranav Garlapati, Payam Vali, Satyan Lakshminrusimha, Brian J Smith, Gerald S Zavorsky
BACKGROUND: Infants with hypoxic-ischemic encephalopathy are treated with therapeutic hypothermia and high-frequency ventilation. Fluctuations in PaCO2 during therapeutic hypothermia are associated with poor neurodevelopmental outcomes. Transcutaneous CO2 monitors offer a noninvasive measure of PaCO2 represented by transcutaneously measured partial pressure of carbon dioxide (PtcCO2 ). We aimed to assess the precision between PtcCO2 and PaCO2 values in neonates undergoing therapeutic hypothermia...
May 30, 2023: Respiratory Care
#34
JOURNAL ARTICLE
Levi Groen, Iris Kloots, David Englert, Kelly Seto, Lana Estafanos, Paul Smith, Gerald W Verhaegh, Niven Mehra, Jack A Schalken
The clinical utility of circulating tumor cells (CTC) as a non-invasive multipurpose biomarker is broadly recognized. The earliest methods for enriching CTCs from whole blood rely on antibody-based positive selection. The prognostic utility of CTC enumeration using positive selection with the FDA-approved CellSearchTM system has been demonstrated in numerous studies. The capture of cells with specific protein phenotypes does not fully represent cancer heterogeneity and therefore does not realize the prognostic potential of CTC liquid biopsies...
May 19, 2023: International Journal of Molecular Sciences
#35
JOURNAL ARTICLE
Kristine A Smith, Amarbir S Gill, Chelsea E Pollard, Jorgen S Sumsion, Hedieh Saffari, Shaelene Ashby, Benjamin L Witt, Paige A Shipman, David A Gabrielsen, Michael T Yim, Joshua M Levy, Gretchen M Oakley, Richard R Orlandi, Gerald J Gleich, Jeremiah A Alt, Abigail Pulsipher
BACKGROUND: A definitive diagnosis of eosinophilic chronic rhinosinusitis (eCRS) requires invasive surgical tissue sampling and histologic enumeration of intact eosinophils. Eosinophil peroxidase (EPX) is an accurate biomarker of sinonasal tissue eosinophilia in CRS regardless of polyp status. A less invasive and rapid method that accurately identifies tissue eosinophilia would be of great benefit to patients. OBJECTIVE: The objective of this investigation was to evaluate a new clinical tool that utilizes a nasal swab and colorimetric EPX activity assay to predict a diagnosis of eCRS...
May 4, 2023: Journal of Allergy and Clinical Immunology
#36
JOURNAL ARTICLE
Robyn Mitchell, Joelle Cayen, Nisha Thampi, Charles Frenette, Jessica Bartoskzo, Kelly Baekyung Choi, Jeannette L Comeau, John Conly, Chelsey Ellis, Jennifer Ellison, John Embil, Gerald Evans, Lynn Johnston, Jennie Johnstone, Kevin C Katz, Pamela Kibsey, Bonita Lee, Marie-Astrid Lefebvre, Yves Longtin, Allison McGeer, Dominik Mertz, Jessica Minion, Wallis Rudnick, Anada Silva, Stephanie W Smith, Jocelyn A Srigley, Kathryn N Suh, Jen Tomlinson, Alice Wong, Linda Pelude
IMPORTANCE: Trends in COVID-19 severe outcomes have significant implications for the health care system and are key to informing public health measures. However, data summarizing trends in severe outcomes among patients hospitalized with COVID-19 in Canada are not well described. OBJECTIVE: To describe trends in severe outcomes among patients hospitalized with COVID-19 during the first 2 years of the COVID-19 pandemic. DESIGN, SETTING, AND PARTICIPANTS: Active prospective surveillance in this cohort study was conducted from March 15, 2020, to May 28, 2022, at a sentinel network of 155 acute care hospitals across Canada...
April 3, 2023: JAMA Network Open
#37
JOURNAL ARTICLE
Gerald W Smetana, C Christopher Smith, Ajay Singla, Howard Libman
Lower urinary tract symptoms due to benign prostatic hyperplasia (BPH) are common in older patients assigned male sex at birth, regardless of gender identity, and treatment of these symptoms is therefore common in primary care practice. In 2021, the American Urological Association published guidelines for management of BPH. They recommend using a standardized scoring system such as the International Prostate Symptom Score to help establish a diagnosis and to monitor the efficacy of interventions, α-blockers as the first-choice pharmacotherapy option, and 5α-reductase inhibitors for patients with prostate size estimated to be at least 30 cc...
April 2023: Annals of Internal Medicine
#38
MULTICENTER STUDY
Michael J Reardon, Bassem Chehab, Dave Smith, Antony S Walton, Stephen G Worthley, Ganesh Manoharan, Ibrahim Sultan, Gerald Yong, Katherine Harrington, Paul Mahoney, Neal Kleiman, Raj R Makkar, Gregory Fontana, Augustin DeLago, Ravi K Ramana, Nicholas Bates, Lars Søndergaard
BACKGROUND: The self-expanding, intra-annular Navitor (Abbott Structural Heart) valve includes an outer cuff to reduce paravalvular leak (PVL) and large stent cells for future coronary access. OBJECTIVES: The purpose of the PORTICO NG (Evaluation of the Portico NG [Next Generation] Transcatheter Aortic Valve in High and Extreme Risk Patients With Symptomatic Severe Aortic Stenosis) study is to evaluate the safety and effectiveness of the Navitor valve in patients with symptomatic, severe aortic stenosis who are at high or extreme surgical risk...
March 27, 2023: JACC. Cardiovascular Interventions
#39
JOURNAL ARTICLE
Megan N Landis, Stacy R Smith, Gabriel Berstein, Gerald Fetterly, Pranab Ghosh, Gang Feng, Vivek Pradhan, Sudeepta Aggarwal, Christopher Banfield, Elena Peeva, Michael S Vincent, Jean S Beebe, Sanela Tarabar
BACKGROUND: Plaque psoriasis (PsO) is an inflammatory skin disease driven, in part, by the activation of Janus kinase (JAK) signalling pathways. OBJECTIVE: To assess the efficacy and safety of multiple doses of topical brepocitinib, a tyrosine kinase 2/JAK1 inhibitor, in participants with mild-to-moderate PsO. METHOD: This phase IIb, multicentre, randomised, double-blind study was conducted in two stages. In stage one, participants received one of eight treatments for 12 weeks: brepocitinib 0·1% once daily (QD), 0·3% QD or twice daily (BID), 1·0% QD or BID, 3·0% QD, or vehicle QD or BID...
March 27, 2023: British Journal of Dermatology
#40
JOURNAL ARTICLE
Yan Wang, Ying Chang, Jericho Ortañez, Jesús F Peña, Derreck Carter-House, Nicole K Reynolds, Matthew E Smith, Gerald Benny, Stephen J Mondo, Asaf Salamov, Anna Lipzen, Jasmyn Pangilinan, Jie Guo, Kurt LaButti, William Andreopolous, Andrew Tritt, Keykhosrow Keymanesh, Mi Yan, Kerrie Barry, Igor V Grigoriev, Joseph W Spatafora, Jason E Stajich
Fungi have evolved over millions of years and their species diversity is predicted to be the second largest on the earth. Fungi have cross-kingdom interactions with many organisms which have mutually shaped their evolutionary trajectories. Zygomycete fungi hold a pivotal position in the fungal tree of life and provide important perspectives on the early evolution of fungi from aquatic to terrestrial environments. Phylogenomic analyses have found that zygomycete fungi diversified into two separate clades, the Mucoromycota which are frequently associated with plants and Zoopagomycota that are commonly animal-associated fungi...
March 17, 2023: Genome Biology and Evolution
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