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https://www.readbyqxmd.com/read/29774094/selumetinib-based-therapy-in-uveal-melanoma-patient-derived-xenografts
#1
Didier Decaudin, Rania El Botty, Béré Diallo, Gerald Massonnet, Justine Fleury, Adnan Naguez, Chloé Raymondie, Emma Davies, Aaron Smith, Joanne Wilson, Colin Howes, Paul D Smith, Nathalie Cassoux, Sophie Piperno-Neumann, Sergio Roman-Roman, Fariba Némati
The prognosis of metastatic uveal melanoma (UM) is among the worst of all human cancers. The identification of near-ubiquitous GNAQ/GNA11 mutations and the activation of MAPK signaling in UM have raised hopes of more effective, targeted therapies, based on MEK inhibition, for example. We evaluated the potential of drug combinations to increase the efficacy of the MEK inhibitor selumetinib (AZD6244, ARRY-142886), in UM cell lines and Patient-Derived Xenografts. We first evaluated the combination of selumetinib and DTIC...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29740124/a-targeted-boost-and-sort-immunization-strategy-using-escherichia-coli-bama-identifies-rare-growth-inhibitory-antibodies
#2
Rajesh Vij, Zhonghua Lin, Nancy Chiang, Jean-Michel Vernes, Kelly M Storek, Summer Park, Joyce Chan, Y Gloria Meng, Laetitia Comps-Agrar, Peng Luan, Sophia Lee, Kellen Schneider, Jack Bevers, Inna Zilberleyb, Christine Tam, Christopher M Koth, Min Xu, Avinash Gill, Marcy R Auerbach, Peter A Smith, Steven T Rutherford, Gerald Nakamura, Dhaya Seshasayee, Jian Payandeh, James T Koerber
Outer membrane proteins (OMPs) in Gram-negative bacteria are essential for a number of cellular functions including nutrient transport and drug efflux. Escherichia coli BamA is an essential component of the OMP β-barrel assembly machinery and a potential novel antibacterial target that has been proposed to undergo large (~15 Å) conformational changes. Here, we explored methods to isolate anti-BamA monoclonal antibodies (mAbs) that might alter the function of this OMP and ultimately lead to bacterial growth inhibition...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29722796/a-randomized-multicentre-trial-to-compare-revascularization-with-optimal-medical-therapy-for-the-treatment-of-chronic-total-coronary-occlusions
#3
Gerald S Werner, Victoria Martin-Yuste, David Hildick-Smith, Nicolas Boudou, Georgios Sianos, Valery Gelev, Jose Ramon Rumoroso, Andrejs Erglis, Evald Høj Christiansen, Javier Escaned, Carlo di Mario, Thomas Hovasse, Luis Teruel, Alexander Bufe, Bernward Lauer, Kris Bogaerts, Javier Goicolea, James C Spratt, Anthony H Gershlick, Alfredo R Galassi, Yves Louvard
Aims: The clinical value of percutaneous coronary intervention (PCI) for chronic coronary total occlusions (CTOs) is not established by randomized trials. This study should compare the benefit of PCI vs. optimal medical therapy (OMT) on the health status in patients with at least one CTO. Method and results: Three hundred and ninety-six patients were enrolled in a prospective randomized, multicentre, open-label, and controlled clinical trial to compare the treatment by PCI with OMT with a 2:1 randomization ratio...
May 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29708221/relationships-between-full-day-arm-movement-characteristics-and-developmental-status-in-infants-with-typical-development-as-they-learn-to-reach-an-observational-study
#4
Joanne Shida-Tokeshi, Christianne J Lane, Ivan A Trujillo-Priego, Weiyang Deng, Douglas L Vanderbilt, Gerald E Loeb, Beth A Smith
Background: Advances in wearable sensor technology now allow us to quantify the number, type and kinematic characteristics of bouts of infant arm movement made across a full day in the natural environment. Our aim here was to determine whether the amount and kinematic characteristics of arm movements made across the day in the natural environment were related to developmental status in infants with typical development as they learned to reach for objects using their arms. Methods: We used wearable sensors to measure arm movement across days and months as infants developed arm reaching skills...
April 5, 2018: Gates open research
https://www.readbyqxmd.com/read/29674299/the-experts-live-workshop-of-the-eurocto-club-2017-berlin
#5
Alexander Bufe, Carlo Di Mario, Ulf Landmesser, Markus Meyer Gessner, George Sianos, Roberto Garbo, Carlotta Sorini Dini, Bernward Lauer, Nicolas Boudou, Luca Grancini, Alexandre Avran, Alexander Lauten, Kambis Mashayekhi, David Hildick-Smith, Javier Escaned, Heinz Joachim Buettner, Nicolaus Reifart, Harald Lapp, Alfredo R Galassi, Gerald S Werner
No abstract text is available yet for this article.
April 20, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29652187/blood-transfusion-during-total-ankle-arthroplasty-is-associated-with-increased-in-hospital-complications-and-costs
#6
Michael A Ewing, Samuel R Huntley, Dustin K Baker, Kenneth S Smith, Parke W Hudson, Gerald McGwin, Brent A Ponce, Michael D Johnson
INTRODUCTION: Total ankle arthroplasty (TAA) is an increasingly used, effective treatment for end-stage ankle arthritis. Although numerous studies have associated blood transfusion with complications following hip and knee arthroplasty, its effects following TAA are largely unknown. This study uses data from a large, nationally representative database to estimate the association between blood transfusion and inpatient complications and hospital costs following TAA. METHODS: Using the Nationwide Inpatient Sample (NIS) database from 2004 to 2014, 25 412 patients who underwent TAA were identified, with 286 (1...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29558287/marijuana-use-and-mortality-following-orthopedic-surgical-procedures
#7
Andrew S Moon, Walter Smith, Sawyer Mullen, Brent A Ponce, Gerald McGwin, Ashish Shah, Sameer M Naranje
BACKGROUND: The association between marijuana use and surgical procedures is a matter of increasing societal relevance that has not been well studied in the literature. The primary aim of this study is to evaluate the relationship between marijuana use and in-hospital mortality, as well as to assess associated comorbidities in patients undergoing commonly billed orthopedic surgeries. METHODS: The National Inpatient Sample (NIS) database from 2010 to 2014 was used to determine the odds ratios for the associations between marijuana use and in-hospital mortality, heart failure (HF), stroke, and cardiac disease (CD) in patients undergoing five common orthopedic procedures: hip (THA), knee (TKA), and shoulder arthroplasty (TSA), spinal fusion, and traumatic femur fracture fixation...
March 20, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29555747/monoclonal-antibody-targeting-the-%C3%AE-barrel-assembly-machine-of-escherichia-coli-is-bactericidal
#8
Kelly M Storek, Marcy R Auerbach, Handuo Shi, Natalie K Garcia, Dawei Sun, Nicholas N Nickerson, Rajesh Vij, Zhonghua Lin, Nancy Chiang, Kellen Schneider, Aaron T Wecksler, Elizabeth Skippington, Gerald Nakamura, Dhaya Seshasayee, James T Koerber, Jian Payandeh, Peter A Smith, Steven T Rutherford
The folding and insertion of integral β-barrel membrane proteins into the outer membrane of Gram-negative bacteria is required for viability and bacterial pathogenesis. Unfortunately, the lack of selective and potent modulators to dissect β-barrel folding in vivo has hampered our understanding of this fundamental biological process. Here, we characterize a monoclonal antibody that selectively inhibits an essential component of the Escherichia coli β-barrel assembly machine, BamA. In the absence of complement or other immune factors, the unmodified antibody MAB1 demonstrates bactericidal activity against an E...
March 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29505717/kinetic-modeling-of-accelerated-stability-testing-enabled-by-second-harmonic-generation-microscopy
#9
Zhengtian Song, Sreya Sarkar, Andrew D Vogt, Gerald D Danzer, Casey J Smith, Ellen J Gualtieri, Garth J Simpson
The low limits of detection afforded by second harmonic generation (SHG) microscopy coupled with image analysis algorithms enabled quantitative modeling of the temperature-dependent crystallization of active pharmaceutical ingredients (APIs) within amorphous solid dispersions (ASDs). ASDs, in which an API is maintained in an amorphous state within a polymer matrix, are finding increasing use to address solubility limitations of small-molecule APIs. Extensive stability testing is typically performed for ASD characterization, the time frame for which is often dictated by the earliest detectable onset of crystal formation...
April 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29467978/feasibility-of-a-comprehensive-medical-knowledge-curriculum-in-internal-medicine-using-team-based-learning
#10
Gerald Schynoll, Elizabeth Irish, Joseph Wayne, Raymond Smith
Background : Team-based learning (TBL) is an active learning strategy with descriptions of its use in resident education limited to pilot studies. Objective : We developed a comprehensive medical knowledge TBL curriculum for an internal medicine residency, and assessed feasibility. Methods : We developed a 135-topic TBL curriculum to replace a noon conference lecture series, and implemented it over a 3-year period (2013-2016). In this article we describe the planning, curricular design, faculty recruitment and development, and lesson structure...
February 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29420640/disparities-in-availability-of-essential-medicines-to-treat-non-communicable-diseases-in-uganda-a-poisson-analysis-using-the-service-availability-and-readiness-assessment
#11
Mari Armstrong-Hough, Sandeep P Kishore, Sarah Byakika, Gerald Mutungi, Marcella Nunez-Smith, Jeremy I Schwartz
OBJECTIVE: Although the WHO-developed Service Availability and Readiness Assessment (SARA) tool is a comprehensive and widely applied survey of health facility preparedness, SARA data have not previously been used to model predictors of readiness. We sought to demonstrate that SARA data can be used to model availability of essential medicines for treating non-communicable diseases (EM-NCD). METHODS: We fit a Poisson regression model using 2013 SARA data from 196 Ugandan health facilities...
2018: PloS One
https://www.readbyqxmd.com/read/29336682/preliminary-phylogeny-of-coemansia-kickxellales-with-descriptions-of-four-new-species-from-taiwan
#12
Shu-Cheng Chuang, Hsiao-Man Ho, Nicole Reynolds, Matthew E Smith, Gerald L Benny, Chiu-Yuan Chien, Ju-Lin Tsai
Four new species of Coemansia from Taiwan are described. Three produce spirally twisted sporangiophores, and these new taxa increase the number of species in the Coemansia spiralis complex from three to six. Each new taxon is morphologically unique. Coemansia biformis, sp. nov., has two different asexual reproductive types on the same thallus; one is straight and the other has a spiral fertile region. Coemansia helicoidea, sp. nov., has stoloniferous sporangiophores with a helicoid fertile region. Coemansia pennisetoides, sp...
2017: Mycologia
https://www.readbyqxmd.com/read/29287978/algal-blooms-of-the-18th-and-19th-centuries
#13
Gerald J Smith, Vincent Daniels
Algal blooms, including those containing cyanobacteria, are of environmental concern due to the toxicities of some of the constituent microorganisms. This compromises the safety of freshwater causing illness in livestock and humans. We present historical accounts of algal blooms occurring during the 18th and 19th centuries indicating that the advent of intensive farming in the 17th century provided nutrients for promoting harmful algal blooms.
February 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29230701/estimating-intermittent-individual-spawning-behavior-via-disaggregating-group-data
#14
Joel Nishimura, Rebecca Smith, Kathleen Jensen, Gerald Ankley, Karen Watanabe
In order to understand fish biology and reproduction, it is important to know the fecundity patterns of individual fish, as frequently established by recording the output of mixed-sex groups of fish in a laboratory setting. However, for understanding individual reproductive health and modeling purposes it is important to estimate individual fecundity from group fecundity. We created a multistage method that disaggregates group-level data into estimates for individual-level clutch size and spawning interval distributions...
March 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29204525/sbrt-to-adrenal-metastases-provides-high-local-control-with-minimal-toxicity
#15
Kristin Plichta, Nathan Camden, Muhammed Furqan, Taher Abu Hejleh, Gerald H Clamon, Jun Zhang, Ryan T Flynn, Sudershan K Bhatia, Mark C Smith, John M Buatti, Bryan G Allen
Purpose: The adrenal glands are a common site of metastases because of their rich blood supply. Previously, adrenal metastases were treated with systemic chemotherapy or, more rarely, with surgical resection or palliative radiation therapy. Stereotactic body radiation therapy (SBRT) has recently emerged as an attractive noninvasive approach to definitively treat these lesions. We present our experience in treating adrenal metastases using SBRT and review the current literature. Methods and materials: This is a single-institution retrospective review of patients who received SBRT to adrenal metastases originating from various primary malignancies...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29196618/the-kalancho%C3%A3-genome-provides-insights-into-convergent-evolution-and-building-blocks-of-crassulacean-acid-metabolism
#16
Xiaohan Yang, Rongbin Hu, Hengfu Yin, Jerry Jenkins, Shengqiang Shu, Haibao Tang, Degao Liu, Deborah A Weighill, Won Cheol Yim, Jungmin Ha, Karolina Heyduk, David M Goodstein, Hao-Bo Guo, Robert C Moseley, Elisabeth Fitzek, Sara Jawdy, Zhihao Zhang, Meng Xie, James Hartwell, Jane Grimwood, Paul E Abraham, Ritesh Mewalal, Juan D Beltrán, Susanna F Boxall, Louisa V Dever, Kaitlin J Palla, Rebecca Albion, Travis Garcia, Jesse A Mayer, Sung Don Lim, Ching Man Wai, Paul Peluso, Robert Van Buren, Henrique Cestari De Paoli, Anne M Borland, Hong Guo, Jin-Gui Chen, Wellington Muchero, Yanbin Yin, Daniel A Jacobson, Timothy J Tschaplinski, Robert L Hettich, Ray Ming, Klaus Winter, James H Leebens-Mack, J Andrew C Smith, John C Cushman, Jeremy Schmutz, Gerald A Tuskan
Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis that has evolved independently many times in diverse lineages of flowering plants. We hypothesize that convergent evolution of protein sequence and temporal gene expression underpins the independent emergences of CAM from C3 photosynthesis. To test this hypothesis, we generate a de novo genome assembly and genome-wide transcript expression data for Kalanchoë fedtschenkoi, an obligate CAM species within the core eudicots with a relatively small genome (~260 Mb)...
December 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29128347/routine-use-of-pico-dressings-may-reduce-overall-groin-wound-complication-rates-following-peripheral-vascular-surgery
#17
C A Fleming, M Kuteva, K O'Hanlon, G O'Brien, G McGreal
BACKGROUND: Approximately 19% of morbidity in peripheral vascular surgery is attributable to wound complications, which can result in delayed healing, and also arterial or graft infection leading to limb loss and even mortality in extreme cases. AIM: To determine whether groin wound complications were reduced following the routine introduction of PICO negative pressure wound therapy dressings in patients who underwent peripheral vascular surgery. METHODS: Patients who underwent peripheral vascular surgery from 2011 to 2016 were identified and divided into PICO and non-PICO groups...
May 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29084067/a-randomized-control-trial-of-cardiopulmonary-feedback-devices-and-their-impact-on-infant-chest-compression-quality-a-simulation-study
#18
Andrea L Austin, Carmen N Spalding, Katrina N Landa, Brian R Myer, Cure Donald, Jason E Smith, Gerald Platt, Heather C King
OBJECTIVES: In effort to improve chest compression quality among health care providers, numerous feedback devices have been developed. Few studies, however, have focused on the use of cardiopulmonary resuscitation feedback devices for infants and children. This study evaluated the quality of chest compressions with standard team-leader coaching, a metronome (MetroTimer by ONYX Apps), and visual feedback (SkillGuide Cardiopulmonary Feedback Device) during simulated infant cardiopulmonary resuscitation...
October 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29066544/maternal-but-not-infant-anti-hiv-1-neutralizing-antibody-response-associates-with-enhanced-transmission-and-infant-morbidity
#19
Melissa Ghulam-Smith, Alex Olson, Laura F White, Charles S Chasela, Sascha R Ellington, Athena P Kourtis, Denise J Jamieson, Gerald Tegha, Charles M van der Horst, Manish Sagar
A significant number of infants acquire HIV-1 through their infected mother's breast milk, primarily due to limited access to antiretrovirals. Passive immunization with neutralizing antibodies (nAbs) may prevent this transmission. Previous studies, however, have generated conflicting results about the ability of nAbs to halt mother-to-child transmission (MTCT) and their impact on infant outcomes. This study compared plasma neutralizing activity in exposed infants and the infected mothers ( n = 63) against heterologous HIV-1 variants and the quasispecies present in the mother...
October 24, 2017: MBio
https://www.readbyqxmd.com/read/29061621/detection-and-management-of-familial-hypercholesterolaemia-in-primary-care-in-australia-protocol-for-a-pragmatic-cluster-intervention-study-with-pre-post-intervention-comparisons
#20
Diane E Arnold-Reed, Tom Brett, Lakkhina Troeung, Alistair Vickery, Jacquie Garton-Smith, Damon Bell, Jing Pang, Tegan Grace, Caroline Bulsara, Ian Li, Max Bulsara, Gerald F Watts
INTRODUCTION: Familial hypercholesterolaemia (FH), an autosomal dominant disorder of lipid metabolism, results in accelerated onset of atherosclerosis if left untreated. Lifelong treatment with diet, lifestyle modifications and statins enable a normal lifespan for most patients. Early diagnosis is critical. This protocol trials a primary care-based model of care (MoC) to improve detection and management of FH. METHODS AND ANALYSIS: Pragmatic cluster intervention study with pre-post intervention comparisons in Australian general practices...
October 22, 2017: BMJ Open
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