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https://www.readbyqxmd.com/read/29128347/routine-use-of-pico-dressings-may-reduce-overall-groin-wound-complication-rates-following-peripheral-vascular-surgery
#1
Christina A Fleming, Mariya Kuteva, Karen O'Hanlon, Gavin O'Brien, Gerald McGreal
BACKGROUND: Approximately 19% of morbidity in peripheral vascular surgery is attributable to wound complications, which can result in delayed healing, but also arterial or graft infection leading to limb loss and even mortality in extreme cases. AIM: To determine whether groin wound complications were reduced following the routine introduction of PICO negative pressure wound therapy dressings (Smith & Nephew, Hull, England) in patients who had peripheral vascular surgery...
November 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29084067/a-randomized-control-trial-of-cardiopulmonary-feedback-devices-and-their-impact-on-infant-chest-compression-quality-a-simulation-study
#2
Andrea L Austin, Carmen N Spalding, Katrina N Landa, Brian R Myer, Cure Donald, Jason E Smith, Gerald Platt, Heather C King
OBJECTIVES: In effort to improve chest compression quality among health care providers, numerous feedback devices have been developed. Few studies, however, have focused on the use of cardiopulmonary resuscitation feedback devices for infants and children. This study evaluated the quality of chest compressions with standard team-leader coaching, a metronome (MetroTimer by ONYX Apps), and visual feedback (SkillGuide Cardiopulmonary Feedback Device) during simulated infant cardiopulmonary resuscitation...
October 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29066544/maternal-but-not-infant-anti-hiv-1-neutralizing-antibody-response-associates-with-enhanced-transmission-and-infant-morbidity
#3
Melissa Ghulam-Smith, Alex Olson, Laura F White, Charles S Chasela, Sascha R Ellington, Athena P Kourtis, Denise J Jamieson, Gerald Tegha, Charles M van der Horst, Manish Sagar
A significant number of infants acquire HIV-1 through their infected mother's breast milk, primarily due to limited access to antiretrovirals. Passive immunization with neutralizing antibodies (nAbs) may prevent this transmission. Previous studies, however, have generated conflicting results about the ability of nAbs to halt mother-to-child transmission (MTCT) and their impact on infant outcomes. This study compared plasma neutralizing activity in exposed infants and the infected mothers (n = 63) against heterologous HIV-1 variants and the quasispecies present in the mother...
October 24, 2017: MBio
https://www.readbyqxmd.com/read/29061621/detection-and-management-of-familial-hypercholesterolaemia-in-primary-care-in-australia-protocol-for-a-pragmatic-cluster-intervention-study-with-pre-post-intervention-comparisons
#4
Diane E Arnold-Reed, Tom Brett, Lakkhina Troeung, Alistair Vickery, Jacquie Garton-Smith, Damon Bell, Jing Pang, Tegan Grace, Caroline Bulsara, Ian Li, Max Bulsara, Gerald F Watts
INTRODUCTION: Familial hypercholesterolaemia (FH), an autosomal dominant disorder of lipid metabolism, results in accelerated onset of atherosclerosis if left untreated. Lifelong treatment with diet, lifestyle modifications and statins enable a normal lifespan for most patients. Early diagnosis is critical. This protocol trials a primary care-based model of care (MoC) to improve detection and management of FH. METHODS AND ANALYSIS: Pragmatic cluster intervention study with pre-post intervention comparisons in Australian general practices...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29054815/whole-brain-radiotherapy-or-autologous-stem-cell-transplantation-as-consolidation-strategies-after-high-dose-methotrexate-based-chemoimmunotherapy-in-patients-with-primary-cns-lymphoma-results-of-the-second-randomisation-of-the-international-extranodal-lymphoma
#5
Andrés J M Ferreri, Kate Cwynarski, Elisa Pulczynski, Christopher P Fox, Elisabeth Schorb, Paul La Rosée, Mascha Binder, Alberto Fabbri, Valter Torri, Eleonora Minacapelli, Monica Falautano, Fiorella Ilariucci, Achille Ambrosetti, Alexander Roth, Claire Hemmaway, Peter Johnson, Kim M Linton, Tobias Pukrop, Jette Sønderskov Gørløv, Monica Balzarotti, Georg Hess, Ulrich Keller, Stephan Stilgenbauer, Jens Panse, Alessandra Tucci, Lorella Orsucci, Francesco Pisani, Alessandro Levis, Stefan W Krause, Hans J Schmoll, Bernd Hertenstein, Mathias Rummel, Jeffery Smith, Michael Pfreundschuh, Giuseppina Cabras, Francesco Angrilli, Maurilio Ponzoni, Martina Deckert, Letterio S Politi, Jürgen Finke, Michele Reni, Franco Cavalli, Emanuele Zucca, Gerald Illerhaus
BACKGROUND: The International Extranodal Lymphoma Study Group-32 (IELSG32) trial is an international randomised phase 2 study that addresses two key clinical questions in the treatment of patients with newly diagnosed primary CNS lymphoma. Results of the first randomisation have demonstrated that methotrexate, cytarabine, thiotepa, and rituximab (called the MATRix regimen) is the induction combination associated with significantly better outcome compared with the other induction combinations tested...
October 17, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29034821/abstracts-and-workshops-7th-national-spinal-cord-injury-conference-november-9-11-2017-fallsview-casino-resort-niagara-falls-ontario-canada
#6
Mir Hatef Shojaei, Mohammad Alavinia, B Catharine Craven, Christiana L Cheng, Tova Plashkes, Tian Shen, Nader Fallah, Suzanne Humphreys, Colleen O'Connell, Angelo Gary Linassi, Chester Ho, Christine Short, Karen Ethans, Rebecca Charbonneau, Jerome Paquet, Vanessa K Noonan, Julio C Furlan, Michael G Fehlings, B Catharine Craven, Jirapat Likitlersuang, Elizabeth Sumitro, Sukhvinder Kalsi-Ryan, José Zariffa, Dalton Wolfe, Stephanie Cornell, Julie Gagliardi, Stephanie Marrocco, Carly S Rivers, Nader Nader Fallah, Vanessa K Noonan, David Whitehurst, Carolyn Schwartz, Joel Finkelstein, B Catharine Craven, Karen Ethans, Colleen O'Connell, Catherine Truchon, Chester Ho, A Gary Linassi, Christine Short, Eve Tsai, Brian Drew, Henry Ahn, Marcel F Dvorak, Jérôme Paquet, Michael G Fehlings, Luc Noreau, Katie Lenz, K Alysse Bailey, David Allison, David Ditor, Justine Baron, Jennifer Tomasone, Dorothyann Curran, Toba Miller, Jeremy Grimshaw, Bastien Moineau, Milad Alizadeh-Meghrazi, Gabriel Stefan, Kei Masani, Milos R Popovic, Elizabeth Sumitro, Jirapat Likitlersuang, Sukhvinder Kalsi-Ryan, José Zariffa, Martha G Garcia-Garcia, Cesar Marquez-Chin, Milos R Popovic, Julio C Furlan, Sivakumar Gulasingam, B Catharine Craven, Julio C Furlan, Sivakumar Gulasingam, B Catharine Craven, Alia Khan, Clara Pujol, Mark Laylor, Nikola Unic, Maureen Pakosh, Kristin Musselman, Louise M Brisbois, B Catharine Craven, Mary C Verrier, Maryleen K Jones, Roberta O'Shea, Sakina Valika, Kaila Holtz, Elena Szefer, Vanessa Noonan, Brian Kwon, Patricia Mills, Cynthia Morin, Anne Harris, Christiana Cheng, Arlene Aspinall, Tova Plashkes, Vanessa K Noonan, Katherine Chan, Mary C Verrier, B Catharine Craven, Chris Alappat, Heather M Flett, Julio C Furlan, Kristin E Musselman, James Milligan, Loretta M Hillier, Craig Bauman, Lindsay Donaldson, Joseph Lee, James Milligan, Joseph Lee, Loretta M Hillier, Karen Slonim, Dalton Wolfe, Lindsay Sleeth, Samantha Jeske, Anna Kras-Dupuis, Stephanie Marrocco, Samantha McRae, Heather Flett, Jennifer Mokry, Joanne Zee, Mark Bayley, Jean-Francois Lemay, Audrey Roy, H Dany Gagnon, Maryleen K Jones, Roberta O'Shea, Renee Theiss, Heather Flett, Kristina Guy, Gillian Johnston, Melanie Kokotow, Sandra Mills, Jennifer Mokry, Patricia Bain, Carol Scovil, Pamela Houghton, Deena Lala, Lyndsay Orr, Paul Holyoke, Dalton Wolfe, Lyndsay Orr, Jillian Brooke, Paul Holyoke, Deena Lala, Pamela Houghton, Kathleen A Martin Ginis, Robert B Shaw, Matthew J Stork, Christopher B McBride, Julio C Furlan, B Catharine Craven, Lora Giangregorio, Sander Hitzig, Naaz Kapadia, Milos R Popovic, Vera Zivanovic, Taufik Valiante, Milos R Popovic, Eleni Patsakos, Louise Brisbois, Farnoosh Farahani, Anita Kaiser, B Catharine Craven, Eleni Patsakos, Anita Kaiser, Louise Brisbois, Farnoosh Farahani, B Catharine Craven, Ben Mortenson, Megan MacGillivray, Sadeghi Mahsa, Jared Adams, Bonita Sawatzky, Patricia Mills, Kelly Arbour-Nicitopoulos, Rebecca Bassett-Gunter, Jennifer Leo, Ritu Sharma, Amy Latimer-Cheung, Timothy Olds, Kathleen Martin Ginis, Marnie Graco, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib Ayas, Rachel Schembri, Lauren Booker, Carmel Nicholls, Patricia Burns, Mark Nash, Sally Green, David J Berlowitz, Samantha Taran, Meredith Rocchi, Kathleen A Martin Ginis, Shane N Sweet, Jeffrey G Caron, Shane N Sweet, Meredith A Rocchi, Walter Zelaya, Shane N Sweet, Austin J Bergquist, Mikael F Del Castillo-Valenzuela, Milos R Popovic, Kei Masani, Karen Ethans, Alan Casey, Micheal Namaka, Dimitri Krassiokov-Enns, Cesar Marquez-Chin, Aaron Marquis, Naaz Desai, Vera Zivanovic, Debbie Hebert, Milos R Popovic, Julio C Furlan, B Catharine Craven, Jonathan McLeod, Audrey Hicks, Cindy Gauthier, Jasmine Arel, Rachel Brosseau, Audrey L Hicks, Dany H Gagnon, Nasrin Nejatbakhsh, Anita Kaiser, Sander L Hitzig, Shauna Cappe, Colleen McGillivray, Hardeep Singh, Jaya Sam, Heather Flett, B Catharine Craven, Mary Verrier, Kristin Musselman, Ryan G L Koh, Purbasha Garai, José Zariffa, Janelle Unger, Alison R Oates, Tarun Arora, Kristin Musselman, Bondi Moshe, Burns Anthony, Sivakumar Gulasingam, B Catharine Craven, Emilie Michalovic, Heather L Gainforth, Justine Baron, Ian D Graham, Shane N Sweet, Brian Chan, B Catharine Craven, Walter Wodchis, Suzanne Cadarette, Murray Krahn, Nicole Mittmann, Keryn Chemtob, Meredith A Rocchi, Kelly Arbour-Nicitopoulos, Dahlia Kairy, Shane N Sweet, Parisa Sabetian, Ryan G L Koh, José Zariffa, Paul Yoo, Stephanie N Iwasa, Robart Babona-Pilipos, Patrick Schneider, Prashanth Velayudhan, Umalkhair Ahmed, Milos R Popovic, Cindi M Morshead, Jaeeun Yoo, Masahiro Shinya, Matija Milosevic, Kei Masani, Sharon Gabison, Sunita Mathur, Ethne Nussbaum, Milos Popovic, Mary C Verrier, Kristin Musselman, Jean-François Lemay, Shane McCullum, Kristina Guy, Kristen Walden, Jose Zariffa, Sukhvinder Kalsi-Ryan, Milad Alizadeh-Meghrazi, Joseph Lee, James Milligan, Matt Smith, Peter Athanasopoulos, Tara Jeji, Jennifer Howcroft, Jeremy Howcroft, Andrea Townson, Rhonda Willms, Tova Plashkes, Sandra Mills, Heather Flett, Carol Scovil, Filomena Mazzella, Helen Morris, Anellina Ventre, Eldon Loh, Stacey Guy, John Kramer, Tara Jeji, Nancy Xia, Swati Mehta, Kathleen A Martin Ginis, Christopher B McBride, Robert B Shaw, Christopher West, Karen Ethans, Colleen O'Connell, Susan Charlifue, Dany H Gagnon, Manuel Jose Escalona Castillo, Martin Vermette, Lívia Pinheiro Carvalho, Antony Karelis, Dahlia Kairy, Mylène Aubertin-Leheudre, Cyril Duclos, Pamela E Houghton, Lyndsay Orr, Paul Holyoke, Anna Kras-Dupuis, Dalton Wolfe, Barry Munro, Michelle Sweeny, B Catharine Craven, Heather Flett, Sander Hitzig, Farnoosh Farahani, S Mohammad Alavinia, Maryam Omidvar, Mark Bayley, Shane N Sweet, Julie Gassaway, Rob Shaw, Minna Hong, Sarah Everhart-Skeels, Bethlyn Houlihan, Anthony Burns, Gerald Bilsky, Indira Lanig, Marnie Graco, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib Ayas, Rachel Schembri, Lauren Booker, Carmel Nicholls, Patricia Burns, Mark Nash, Sally Green, David Berlowitz, Julio C Furlan, Sukhvinder Kalsi-Ryan
No abstract text is available yet for this article.
November 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28988680/macroscopic-anisotropic-bone-material-properties-in-children-with-severe-osteogenesis-imperfecta
#7
Carolyne Albert, John Jameson, Sergey Tarima, Peter Smith, Gerald Harris
Children with severe osteogenesis imperfecta (OI) typically experience numerous fractures and progressive skeletal deformities over their lifetime. Recent studies proposed finite element models to assess fracture risk and guide clinicians in determining appropriate intervention in children with OI, but lack of appropriate material property inputs remains a challenge. This study aimed to characterize macroscopic anisotropic cortical bone material properties and investigate relationships with bone density measures in children with severe OI...
September 14, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28977602/dipeptidyl-peptidase-4-inhibition-with-saxagliptin-ameliorates-angiotensin-ii-induced-cardiac-diastolic-dysfunction-in-male-mice
#8
Scott M Brown, Cassandra E Smith, Alex I Meuth, Maloree Khan, Annayya R Aroor, Hannah M Cleeton, Gerald A Meininger, James R Sowers, Vincent G DeMarco, Bysani Chandrasekar, Ravi Nistala, Shawn B Bender
Activation of the renin-angiotensin-aldosterone system is common in hypertension and obesity and contributes to cardiac diastolic dysfunction, a condition for which no treatment currently exists. In light of recent reports that antihyperglycemia incretin enhancing dipeptidyl peptidase (DPP)-4 inhibitors exert cardioprotective effects, we examined the hypothesis that DPP-4 inhibition with saxagliptin (Saxa) attenuates angiotensin II (Ang II)-induced cardiac diastolic dysfunction. Male C57BL/6J mice were infused with either Ang II (500 ng/kg/min) or vehicle for 3 weeks receiving either Saxa (10 mg/kg/d) or placebo during the final 2 weeks...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28976817/hematopoietic-stem-cell-gene-therapy-for-cerebral-adrenoleukodystrophy
#9
MULTICENTER STUDY
Florian Eichler, Christine Duncan, Patricia L Musolino, Paul J Orchard, Satiro De Oliveira, Adrian J Thrasher, Myriam Armant, Colleen Dansereau, Troy C Lund, Weston P Miller, Gerald V Raymond, Raman Sankar, Ami J Shah, Caroline Sevin, H Bobby Gaspar, Paul Gissen, Hernan Amartino, Drago Bratkovic, Nicholas J C Smith, Asif M Paker, Esther Shamir, Tara O'Meara, David Davidson, Patrick Aubourg, David A Williams
BACKGROUND: In X-linked adrenoleukodystrophy, mutations in ABCD1 lead to loss of function of the ALD protein. Cerebral adrenoleukodystrophy is characterized by demyelination and neurodegeneration. Disease progression, which leads to loss of neurologic function and death, can be halted only with allogeneic hematopoietic stem-cell transplantation. METHODS: We enrolled boys with cerebral adrenoleukodystrophy in a single-group, open-label, phase 2-3 safety and efficacy study...
October 26, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28973304/exome-wide-association-study-reveals-novel-psoriasis-susceptibility-locus-at-tnfsf15-and-rare-protective-alleles-in-genes-contributing-to-type-i-ifn-signalling
#10
Nick Dand, Sören Mucha, Lam C Tsoi, Satveer K Mahil, Philip E Stuart, Andreas Arnold, Hansjörg Baurecht, A David Burden, Kristina Callis Duffin, Vinod Chandran, Charles J Curtis, Sayantan Das, David Ellinghaus, Eva Ellinghaus, Charlotta Enerback, Tõnu Esko, Dafna D Gladman, Christopher E M Griffiths, Johann E Gudjonsson, Per Hoffman, Georg Homuth, Ulrike Hüffmeier, Gerald G Krueger, Matthias Laudes, Sang Hyuck Lee, Wolfgang Lieb, Henry W Lim, Sabine Löhr, Ulrich Mrowietz, Martina Müller-Nurayid, Markus Nöthen, Annette Peters, Proton Rahman, André Reis, Nick J Reynolds, Elke Rodriguez, Carsten O Schmidt, Sarah L Spain, Konstantin Strauch, Trilokraj Tejasvi, John J Voorhees, Richard B Warren, Michael Weichenthal, Stephan Weidinger, Matthew Zawistowski, Rajan P Nair, Francesca Capon, Catherine H Smith, Richard C Trembath, Goncalo R Abecasis, James T Elder, Andre Franke, Michael A Simpson, Jonathan N Barker
Psoriasis is a common inflammatory skin disorder for which multiple genetic susceptibility loci have been identified, but few resolved to specific functional variants. In this study, we sought to identify common and rare psoriasis-associated gene-centric variation. Using exome arrays we genotyped four independent cohorts, totalling 11 861 psoriasis cases and 28 610 controls, aggregating the dataset through statistical meta-analysis. Single variant analysis detected a previously unreported risk locus at TNFSF15 (rs6478108; P = 1...
November 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28951389/genetically-determined-plasma-lipid-levels-and-risk-of-diabetic-retinopathy-a-mendelian-randomization-study
#11
Lucia Sobrin, Yong He Chong, Qiao Fan, Alfred Gan, Lynn K Stanwyck, Georgia Kaidonis, Jamie E Craig, Jihye Kim, Wen-Ling Liao, Yu-Chuen Huang, Wen-Jane Lee, Yi-Jen Hung, Xiuqing Guo, Yang Hai, Eli Ipp, Samuela Pollack, Heather Hancock, Alkes Price, Alan Penman, Paul Mitchell, Gerald Liew, Albert V Smith, Vilmundur Gudnason, Gavin Tan, Barbara E K Klein, Jane Kuo, Xiaohui Li, Mark W Christiansen, Bruce M Psaty, Kevin Sandow, Richard A Jensen, Ronald Klein, Mary Frances Cotch, Jie Jin Wang, Yucheng Jia, Ching J Chen, Yii-Der Ida Chen, Jerome I Rotter, Fuu-Jen Tsai, Craig L Hanis, Kathryn P Burdon, Tien Yin Wong, Ching-Yu Cheng
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization (MR) approach. We pooled genome-wide association studies summary statistics from 18 studies for 2 DR phenotypes: any DR (N=2,969 case; 4,096 controls) and severe DR, (N=1,277 cases; 3,980 controls). Previously identified lipid-associated single nucleotide polymorphisms (SNPs) served as instrumental variables...
September 26, 2017: Diabetes
https://www.readbyqxmd.com/read/28935847/cd56-bright-natural-killer-regulatory-cells-in-filgrastim-primed-donor-blood-or-marrow-products-regulate-chronic-graft-versus-host-disease-the-canadian-blood-and-marrow-transplant-group-randomized-0601-study-results
#12
Amina Kariminia, Sabine Ivison, Bernard Ng, Jacob Rozmus, Susanna Sung, Avani Varshney, Mahmoud Aljurf, Sylvie Lachance, Irwin Walker, Cindy Toze, Jeff Lipton, Stephanie J Lee, Jeff Szer, Richard Doocey, Ian Lewis, Clayton Smith, Naeem Chaudhri, Megan K Levings, Raewyn Broady, Gerald Devins, David Szwajcer, Ronan Foley, Sara Mostafavi, Steven Pavletic, Donna A Wall, Stephan Couban, Tony Panzarella, Kirk R Schultz
Randomized trials have conclusively shown higher rates of chronic graft-versus-host disease with filgrastim-stimulated apheresis peripheral blood as a donor source than unstimulated bone marrow. The Canadian Blood and Marrow Transplant Group conducted a phase 3 study of adults who received either filgrastim-stimulated apheresis peripheral blood or filgrastim-stimulated bone marrow from human leukocyte antigen-identical sibling donors. Because all donors received the identical filgrastim dosing schedule, this study allowed for a controlled evaluation of the impact of stem cell source on development of chronic graft-versus-host disease...
November 2017: Haematologica
https://www.readbyqxmd.com/read/28902707/impact-of-human-ca8-on-thermal-antinociception-in-relation-to-morphine-equivalence-in-mice
#13
Eugene S Fu, Diana M Erasso, Gerald Z Zhuang, Udita Upadhyay, Mehtap Ozdemir, Timothy Wiltshire, Konstantinos D Sarantopoulos, Shad B Smith, William Maixner, Eden R Martin, Roy C Levitt
Recently, we showed that murine dorsal root ganglion (DRG) Car8 expression is a cis-regulated eQTL that determines analgesic responses. In this report, we show that transduction through sciatic nerve injection of DRG with human wild-type carbonic anhydrase-8 using adeno-associated virus viral particles (AAV8-V5-CA8WT) produces analgesia in naive male C57BL/6J mice and antihyperalgesia after carrageenan treatment. A peak mean increase of about 4 s in thermal hindpaw withdrawal latency equaled increases in thermal withdrawal latency produced by 10 mg/kg intraperitoneal morphine in these mice...
December 13, 2017: Neuroreport
https://www.readbyqxmd.com/read/28835200/research-productivity-of-doctor-of-physical-therapy-faculty-promoted-in-the-southeastern-united-states
#14
Marissa A Littman, James W Sonne, Gerald V Smith
BACKGROUND: Little information exists on the research productivity of successfully promoted tenure-track Doctor of Physical Therapy (DPT) faculty. OBJECTIVE: To determine the research productivity that typically results in successful promotion. DESIGN: We collected publicly available curriculum vitae (CVs) from faculty currently in accredited DPT programs and who had been successfully promoted from an institution in the southeastern USA from 2000 through 2016...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28814146/-express-evidence-that-dry-eye-represents-a-chronic-overlapping-pain-condition
#15
Alexandra E Levitt, Anat Galor, Aneesa R Chowdhury, Elizabeth R Felix, Constantinos D Sarantopoulos, Gerald Y Zhuang, Dennis Patin, William Maixner, Shad B Smith, Eden R Martin, Roy C Levitt
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28810149/o2-%C3%A2-and-h2o2-mediated-disruption-of-fe-metabolism-causes-the-differential-susceptibility-of-nsclc-and-gbm-cancer-cells-to-pharmacological-ascorbate
#16
Joshua D Schoenfeld, Zita A Sibenaller, Kranti A Mapuskar, Brett A Wagner, Kimberly L Cramer-Morales, Muhammad Furqan, Sonia Sandhu, Thomas L Carlisle, Mark C Smith, Taher Abu Hejleh, Daniel J Berg, Jun Zhang, John Keech, Kalpaj R Parekh, Sudershan Bhatia, Varun Monga, Kellie L Bodeker, Logan Ahmann, Sandy Vollstedt, Heather Brown, Erin P Shanahan Kauffman, Mary E Schall, Ray J Hohl, Gerald H Clamon, Jeremy D Greenlee, Matthew A Howard, Michael K Schultz, Brian J Smith, Dennis P Riley, Frederick E Domann, Joseph J Cullen, Garry R Buettner, John M Buatti, Douglas R Spitz, Bryan G Allen
No abstract text is available yet for this article.
August 14, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28782881/from-peptide-masses-to-pregnancy-maintenance-a-comprehensive-proteomic-analysis-of-the-early-equine-embryo-secretome-blastocoel-fluid-and-capsule
#17
Aleona Swegen, Christopher G Grupen, Zamira Gibb, Mark A Baker, Marta de Ruijter-Villani, Nathan D Smith, Tom A E Stout, R John Aitken
Early pregnancy in the mare is a poorly understood, high risk period during which the embryo communicates its presence to the maternal endometrium. Remarkably, the maternal recognition of pregnancy signal is unknown in the horse. This study aimed to profile the proteins secreted by equine blastocysts into their immediate environment, along with proteins contained in the blastocoel and within the acellular embryo capsule. Embryos were recovered on day 8 after ovulation and cultured for 48 hours. Secretomes of day 9 and day 10 embryos were analyzed by LC-MS/MS and supported by analysis of blastocoel fluid and embryo capsule...
September 2017: Proteomics
https://www.readbyqxmd.com/read/28781851/cell-free-dna-results-lead-to-unexpected-diagnosis
#18
Jessica Smith, Victoria Kean, Diana W Bianchi, Gerald Feldman, Nancie Petrucelli, Michael Simon, Bernard Gonik
Maternal cell-free DNA (cfDNA) results that are discordant with the diagnostic fetal karyotype should prompt further investigation. If deeper analysis of the cfDNA results demonstrates a "saw-tooth" pattern characteristic of genome-wide imbalance, maternal malignancy is suggested. Identifying the maternal malignancy can, however, be difficult.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28777275/gait-deviations-in-children-with-osteogenesis-imperfecta-type-i
#19
Christina R Garman, Adam Graf, Joseph Krzak, Angela Caudill, Peter Smith, Gerald Harris
BACKGROUND: Osteogenesis imperfecta (OI) is a congenital connective tissue disorder often characterized by orthopaedic complications that impact normal gait. As such, mobility is of particular interest in the OI population as it is associated with multiple aspects of participation and quality of life. The purpose of the current study was to identify and describe common gait deviations in a large sample of individuals with type I OI and speculate the etiology with a goal of improving function...
August 2, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28777274/a-long-term-follow-up-of-young-adults-with-idiopathic-clubfoot-does-foot-morphology-relate-to-pain
#20
Adam N Graf, Ken N Kuo, Nikhil T Kurapati, Joseph J Krzak, Sahar Hassani, Angela K Caudill, Ann Flanagan, Gerald F Harris, Peter A Smith
BACKGROUND: Individuals with clubfoot, treated in infancy with either the Ponseti method or comprehensive clubfoot release, often encounter pain as adults. Multiple studies have characterized residual deformity after Ponseti or surgical correction using physical exam, radiographs and pedobarography; however, the relationship between residual foot deformity and pain is not well defined. The purpose of the current study was 2-fold: (1) to evaluate the relationship between foot morphology and pain for young adults treated as infants for idiopathic clubfoot and (2) to describe and compare pedobarographic measures and outcome measures of pain and morphology among surgically treated, Ponseti treated, and typically developing feet...
August 2, 2017: Journal of Pediatric Orthopedics
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