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https://www.readbyqxmd.com/read/29786432/modular-design-of-fluorescent-dibenzo-and-naphtho-fluoranthenes-structural-rearrangements-and-electronic-properties
#1
Gavin S Mohammad-Pour, Richard T Ly, David C Fairchild, Alex Burnstine-Townley, Demetrius A Vazquez-Molina, Khang D Trieu, Andres D Campiglia, James K Harper, Fernando J Uribe-Romo
A library of twelve dibenzo- and naphtho- fluoranthene polycyclic aromatic hydrocarbons (PAHs) with MW = 302 (C24H14) was synthesized via a Pd-catalyzed fluoranthene ring-closing reaction. By understanding the various modes by which the palladium migrates during the transformation, structural rearrangements were bypassed, obtaining pure PAHs in high yields. Spectroscopic and electrochemical characterization demonstrated the profound diversity in the electronic structures between isomers. Highlighting the significant differences in emission of visible light, this library of PAHs will enable their standardization for toxicological assessment and potential use as optoelectronic materials...
May 22, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29774294/seroprevalence-and-awareness-of-porcine-cysticercosis-across-different-pig-production-systems-in-south-central-cambodia
#2
Aderosoye Adenuga, Ana Mateus, Chhay Ty, Khieu Borin, Davun Holl, Sorn San, Victoria Duggan, Madeleine Clark, Gavin J D Smith, Richard Coker, Andrew Vaughn, James W Rudge
Background: Taeniasis/cysticercosis, caused by the pork tapeworm Taenia solium , represents an important public health and economic burden in endemic countries. However, there is a paucity of data on infection among pigs in many parts of Southeast Asia, particularly Cambodia. We aimed to estimate seroprevalence of porcine cysticercosis, and investigate husbandary practices and knowledge of the disease among livestock workers, across different pig sector units in south-central Cambodia...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29752222/the-berlin-declaration-a-call-to-improve-early-actions-related-to-type-2-diabetes-why-is-primary-care-important
#3
REVIEW
Kamlesh Khunti, James R Gavin, Andrew J M Boulton, Rick Blickstead, Margaret McGill, Antonio Ceriello, Itamar Raz, Shaukat Sadikot, David A Wood, Xavier Cos, Sanjay Kalra, Ashok Kumar Das, Cutberto Espinosa López
Diabetes is epidemic worldwide and places a huge burden on healthcare systems. The majority of the cost of type 2 diabetes (T2D) is related to hospitalization and the management of complications, and these also have a negative impact on the individual's quality of life. The Berlin Declaration is a global call for early action for the identification of high risk individuals, prevention of T2D and the prevention of complications in those with T2D, through prevention, early detection, early control and early access to the right multidisciplinary interventions...
May 8, 2018: Primary Care Diabetes
https://www.readbyqxmd.com/read/29731700/preventing-post-ercp-pancreatitis-the-role-of-prophylactic-pancreatic-duct-stenting-in-the-rectal-nsaid-era
#4
Noor-L-Houda Bekkali, Tom Thomas, Margaret Geraldine Keane, Sam Murray, Deepak Joshi, Ghassan Elsayed, Gavin James Johnson, Michael Huw Chapman, Stephen Paul Pereira, George John Mitchell Webster
Background: Rectal non-steroidal anti-inflammatory drug at endoscopic retrograde cholangiopancreatography is now the standard of care to reduce the risk of post-ERCP pancreatitis. Pancreatic duct stenting also reduces the risk of post- ERCP pancreatitis in high-risk patients, but failed pancreatic duct stenting carries an increased PEP rate (up to 35%). Study Aim: To assess the impact on post-ERCP pancreatitis of successful and unsuccessful pancreatic duct stent placement in the setting of universal rectal non-steroidal anti-inflammatory drug use...
July 2017: JOP: Journal of the Pancreas
https://www.readbyqxmd.com/read/29726967/distinguishing-prognostic-and-predictive-biomarkers-an-information-theoretic-approach
#5
Konstantinos Sechidis, Konstantinos Papangelou, Paul D Metcalfe, David Svensson, James Weatherall, Gavin Brown
Motivation: The identification of biomarkers to support decision-making is central to personalised medicine, in both clinical and research scenarios. The challenge can be seen in two halves: identifying predictive markers, which guide the development/use of tailored therapies; and identifying prognostic markers, which guide other aspects of care and clinical trial planning, i.e. prognostic markers can be considered as covariates for stratification. Mistakenly assuming a biomarker to be predictive, when it is in fact largely prognostic (and vice-versa) is highly undesirable, and can result in financial, ethical and personal consequences...
May 2, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29720618/author-correction-genome-guided-phylo-transcriptomic-methods-and-the-nuclear-phylogenetic-tree-of-the-paniceae-grasses
#6
Jacob D Washburn, James C Schnable, Gavin C Conant, Thomas P Brutnell, Ying Shao, Yang Zhang, Martha Ludwig, Gerrit Davidse, J Chris Pires
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29700993/discovery-of-antimicrobial-lipodepsipeptides-produced-by-a-serratia-sp-within-mosquito-microbiomes
#7
Jack Ganley, Gavin Carr, Thomas Ioerger, James Sacchettini, Jon Clardy, Emily Derbyshire
The Anopheles mosquito that harbors the Plasmodium parasite contains a microbiota that can influence both the vector and parasite. In recent years, insect-associated microbes have highlighted the untapped potential of exploiting interspecies interactions to discover bioactive compounds. In this study, we report the discovery of nonribosomal lipodepsipeptides that are produced by a Serratia sp. within the midgut and salivary glands of A. stephensi mosquitoes. The lipodepsipeptides, stephensiolides A-K, have antibiotic activity and facilitate bacterial surface motility...
April 26, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29700264/quantitative-mass-imaging-of-single-biological-macromolecules
#8
Gavin Young, Nikolas Hundt, Daniel Cole, Adam Fineberg, Joanna Andrecka, Andrew Tyler, Anna Olerinyova, Ayla Ansari, Erik G Marklund, Miranda P Collier, Shane A Chandler, Olga Tkachenko, Joel Allen, Max Crispin, Neil Billington, Yasuharu Takagi, James R Sellers, Cédric Eichmann, Philipp Selenko, Lukas Frey, Roland Riek, Martin R Galpin, Weston B Struwe, Justin L P Benesch, Philipp Kukura
The cellular processes underpinning life are orchestrated by proteins and their interactions. The associated structural and dynamic heterogeneity, despite being key to function, poses a fundamental challenge to existing analytical and structural methodologies. We used interferometric scattering microscopy to quantify the mass of single biomolecules in solution with 2% sequence mass accuracy, up to 19-kilodalton resolution, and 1-kilodalton precision. We resolved oligomeric distributions at high dynamic range, detected small-molecule binding, and mass-imaged proteins with associated lipids and sugars...
April 27, 2018: Science
https://www.readbyqxmd.com/read/29691324/suppression-of-costimulation-by-human-cytomegalovirus-promotes-evasion-of-cellular-immune-defenses
#9
Eddie C Y Wang, Mariana Pjechova, Katie Nightingale, Virginia-Maria Vlahava, Mihil Patel, Eva Ruckova, Simone K Forbes, Luis Nobre, Robin Antrobus, Dawn Roberts, Ceri A Fielding, Sepehr Seirafian, James Davies, Isa Murrell, Betty Lau, Gavin S Wilkie, Nicolás M Suárez, Richard J Stanton, Borivoj Vojtesek, Andrew Davison, Paul J Lehner, Michael P Weekes, Gavin W G Wilkinson, Peter Tomasec
CD58 is an adhesion molecule that is known to play a critical role in costimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded gene that inhibits CD58 surface expression. Human cytomegalovirus (HCMV) UL148 was necessary and sufficient to promote intracellular retention of CD58 during HCMV infection. Blocking studies with antagonistic anti-CD58 mAb and an HCMV UL148 deletion mutant (HCMV∆UL148) with restored CD58 expression demonstrated that the CD2/CD58 axis was essential for the recognition of HCMV-infected targets by CD8+ HCMV-specific cytotoxic T lymphocytes (CTLs)...
April 24, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29687195/professor-gavin-c-arneil-1923-2018
#10
EDITORIAL
Heather Maxwell, David A Hughes, T James Beattie
No abstract text is available yet for this article.
April 23, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29596943/the-berlin-declaration-a-call-to-action-to-improve-early-actions-related-to-type-2-diabetes-how-can-specialist-care-help
#11
Antonio Ceriello, James Gavin, Andrew J M Boulton, Rick Blickstead, Margaret McGill, Itamar Raz, Shaukat Sadikot, David Wood, Xavier Cos, Kamlesh Khunti, Sanjay Kalra, Ashok Kumar Das, Cutberto Espinosa López
Diabetes is a major global epidemic and places a huge burden on healthcare systems worldwide. The complications of type 2 diabetes (T2D) and related hospitalizations are major contributors to this burden, and there is strong evidence that the risk for these can be reduced by early action to identify and prevent people at high risk of T2D and ensure tight glycemic control in those with established disease. In response to this, the Berlin Declaration was developed by four working groups of experts and ratified by healthcare professionals from 38 countries...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29559292/implications-of-pathologic-complete-response-beyond-mediastinal-nodal-clearance-with-high-dose-neoadjuvant-chemoradiation-therapy-in-locally-advanced-non-small-cell-lung-cancer
#12
Melissa A L Vyfhuis, Whitney M Burrows, Neha Bhooshan, Mohan Suntharalingam, James M Donahue, Josephine Feliciano, Shahed Badiyan, Elizabeth M Nichols, Martin J Edelman, Shamus R Carr, Joseph Friedberg, Gavin Henry, Shelby Stewart, Ashutosh Sachdeva, Edward M Pickering, Charles B Simone, Steven J Feigenberg, Pranshu Mohindra
PURPOSE: To determine, in a retrospective analysis of a large cohort of stage III non-small cell lung cancer patients treated with curative intent at our institution, whether having a pathologic complete response (pCR) influenced overall survival (OS) or freedom from recurrence (FFR) in patients who underwent definitive (≥60 Gy) neoadjuvant doses of chemoradiation (CRT). METHODS AND MATERIALS: At our institution, 355 patients with locally advanced non-small cell lung cancer were treated with curative intent with definitive CRT (January 2000-December 2013), of whom 111 underwent mediastinal reassessment for possible surgical resection...
February 13, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29535388/integrative-genomic-profiling-of-large-cell-neuroendocrine-carcinomas-reveals-distinct-subtypes-of-high-grade-neuroendocrine-lung-tumors
#13
Julie George, Vonn Walter, Martin Peifer, Ludmil B Alexandrov, Danila Seidel, Frauke Leenders, Lukas Maas, Christian Müller, Ilona Dahmen, Tiffany M Delhomme, Maude Ardin, Noemie Leblay, Graham Byrnes, Ruping Sun, Aurélien De Reynies, Anne McLeer-Florin, Graziella Bosco, Florian Malchers, Roopika Menon, Janine Altmüller, Christian Becker, Peter Nürnberg, Viktor Achter, Ulrich Lang, Peter M Schneider, Magdalena Bogus, Matthew G Soloway, Matthew D Wilkerson, Yupeng Cun, James D McKay, Denis Moro-Sibilot, Christian G Brambilla, Sylvie Lantuejoul, Nicolas Lemaitre, Alex Soltermann, Walter Weder, Verena Tischler, Odd Terje Brustugun, Marius Lund-Iversen, Åslaug Helland, Steinar Solberg, Sascha Ansén, Gavin Wright, Benjamin Solomon, Luca Roz, Ugo Pastorino, Iver Petersen, Joachim H Clement, Jörg Sänger, Jürgen Wolf, Martin Vingron, Thomas Zander, Sven Perner, William D Travis, Stefan A Haas, Magali Olivier, Matthieu Foll, Reinhard Büttner, David Neil Hayes, Elisabeth Brambilla, Lynnette Fernandez-Cuesta, Roman K Thomas
Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we perform a comprehensive genomic (n = 60) and transcriptomic (n = 69) analysis of 75 LCNECs and identify two molecular subgroups: "type I LCNECs" with bi-allelic TP53 and STK11/KEAP1 alterations (37%), and "type II LCNECs" enriched for bi-allelic inactivation of TP53 and RB1 (42%). Despite sharing genomic alterations with adenocarcinomas and squamous cell carcinomas, no transcriptional relationship was found; instead LCNECs form distinct transcriptional subgroups with closest similarity to SCLC...
March 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29528834/invited-commentary-on-imaging-of-intestinal-and-multivisceral-transplantation
#14
COMMENT
Gavin Low, A M James Shapiro
No abstract text is available yet for this article.
March 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29499060/household-point-of-care-cd4-testing-and-isoniazid-preventive-therapy-initiation-in-a-household-tb-contact-tracing-programme-in-two-districts-of-south-africa
#15
Liesl Page-Shipp, James J Lewis, Kavindhran Velen, Sedikanelo Senoge, Elizabeth Zishiri, Flora Popane, Violet N Chihota, Dave Clark, Gavin J Churchyard, Salome Charalambous
BACKGROUND: In South Africa, TB household contact tracing provides an opportunity for increased TB and HIV case finding. We aimed to determine the effect of two new potential interventions for TB contact tracing programmes: Point of Care CD4 (PoC CD4) on HIV linkage to care and household Isoniazid Preventive Therapy (IPT) provision on uptake and retention of IPT. METHODS: A pragmatic, three-arm, cluster-randomized trial was undertaken. TB Household contacts were randomised to 3 arms: 1) Standard of Care TB and HIV testing (SOC); 2) SOC with POC CD4 for those testing HIV positive; 3) SOC with POC CD4 and IPT for eligible household members...
2018: PloS One
https://www.readbyqxmd.com/read/29497684/multicenter-experience-from-the-uk-and-ireland-of-use-of-lumen-apposing-metal-stent-for-transluminal-drainage-of-pancreatic-fluid-collections
#16
Suresh Vasan Venkatachalapathy, Noor Bekkali, Stephen Pereira, Gavin Johnson, Kofi Oppong, Manu Nayar, John Leeds, Bharat Paranandi, Ian Penman, Nicholas Carroll, Edmund Godfrey, Martin James, Guruprasad Aithal, Colin McKay, John Devlin, Terry Wong, Alistair Makin, Barbara Ryan, Matthew Huggett
Background and study aims:  Pancreatic fluid collection (PFC) is a common complication of pancreatitis for which endoscopic ultrasound-guided drainage is first-line treatment. A new single-device, lumen-apposing, covered self-expanding metal stent (LAMS) has been licensed for PFC drainage. We therefore present our multicenter experience with the LAMS for PFC drainage in a multicenter prospective case series to assess success and complication rates. Patients and methods:  All adult patients from 11 tertiary centers who had LAMS placement for PFC from July 2015 to July 2016 were included...
March 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29489050/urinary-bowel-and-sexual-health-in-older-men-from-northern-ireland
#17
David W Donnelly, Conan Donnelly, Therese Kearney, David Weller, Linda Sharp, Amy Downing, Sarah Wilding, Penny Wright, Paul Kind, James W F Catto, William R Cross, Malcolm D Mason, Eilis McCaughan, Richard Wagland, Eila Watson, Rebecca Mottram, Majorie Allen, Hugh Butcher, Luke Hounsome, Peter Selby, Dyfed Huws, David H Brewster, Emma McNair, Carol Rivas, Johana Nayoan, Mike Horton, Lauren Matheson, Adam W Glaser, Anna Gavin
OBJECTIVES: To provide data on the prevalence of urinary, bowel and sexual dysfunction in Northern Ireland (NI), to act as a baseline for studies of prostate cancer outcomes and to aid service provision within the general population. SUBJECTS AND METHODS: A cross-sectional postal survey of 10 000 men aged ≥40 years in NI was conducted and age-matched to the distribution of men living with prostate cancer. The EuroQoL five Dimensions five Levels (EQ-5D-5L) and 26-item Expanded Prostate Cancer Composite (EPIC-26) instruments were used to enable comparisons with prostate cancer outcome studies...
February 28, 2018: BJU International
https://www.readbyqxmd.com/read/29443381/guillain-barr%C3%A3-like-syndrome-during-pembrolizumab-treatment
#18
Stephanie Ong, James Chapman, Gavin Young, Talal Mansy
No abstract text is available yet for this article.
February 14, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29438696/the-integrated-genomic-landscape-of-thymic-epithelial-tumors
#19
Milan Radovich, Curtis R Pickering, Ina Felau, Gavin Ha, Hailei Zhang, Heejoon Jo, Katherine A Hoadley, Pavana Anur, Jiexin Zhang, Mike McLellan, Reanne Bowlby, Thomas Matthew, Ludmila Danilova, Apurva M Hegde, Jaegil Kim, Mark D M Leiserson, Geetika Sethi, Charles Lu, Michael Ryan, Xiaoping Su, Andrew D Cherniack, Gordon Robertson, Rehan Akbani, Paul Spellman, John N Weinstein, D Neil Hayes, Ben Raphael, Tara Lichtenberg, Kristen Leraas, Jean Claude Zenklusen, Junya Fujimoto, Cristovam Scapulatempo-Neto, Andre L Moreira, David Hwang, James Huang, Mirella Marino, Robert Korst, Giuseppe Giaccone, Yesim Gokmen-Polar, Sunil Badve, Arun Rajan, Philipp Ströbel, Nicolas Girard, Ming S Tsao, Alexander Marx, Anne S Tsao, Patrick J Loehrer
Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs, thymoma is the most predominant, characterized by a unique association with autoimmune diseases, followed by thymic carcinoma, which is less common but more clinically aggressive. Using multi-platform omics analyses on 117 TETs, we define four subtypes of these tumors defined by genomic hallmarks and an association with survival and World Health Organization histological subtype. We further demonstrate a marked prevalence of a thymoma-specific mutated oncogene, GTF2I, and explore its biological effects on multi-platform analysis...
February 12, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29398336/exclusive-enteral-nutrition-in-crohn-s-disease-evidence-and-practicalities
#20
REVIEW
James J Ashton, Joan Gavin, R Mark Beattie
Exclusive enteral nutrition (EEN) is the first line therapy for paediatric Crohn's disease, providing a complete nutritional feed whilst simultaneously inducing remission in up to 80% of cases. The effect of EEN on systemic/local intestinal immune function and subsequent inflammation (including barrier permeability, direct anti-inflammatory effects and cytokine signalling pathways), alongside changes in the microbiome (specific species and broad taxonomic shifts, functional changes) are becoming clearer, however the exact mechanism for induction of remission in Crohn's disease remains uncertain...
February 1, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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