keyword
https://read.qxmd.com/read/38690427/bilateral-remote-ischemic-conditioning-in-children-a-two-center-double-blind-randomized-controlled-trial-in-young-children-undergoing-cardiac-surgery
#1
Nigel E Drury, Carin van Doorn, Rebecca L Woolley, Rebecca J Amos-Hirst, Rehana Bi, Collette M Spencer, Kevin P Morris, James Montgomerie, John Stickley, Adrian Crucean, Alicia Gill, Matt Hill, Ralf J M Weber, Lukas Najdekr, Andris Jankevics, Andrew D Southam, Gavin R Lloyd, Osama Jaber, Imre Kassai, Giuseppe Pelella, Natasha E Khan, Phil Botha, David J Barron, Melanie Madhani, Warwick B Dunn, Natalie J Ives, Paulus Kirchhof, Timothy J Jones
OBJECTIVE: The study objective was to determine whether adequately delivered bilateral remote ischemic preconditioning is cardioprotective in young children undergoing surgery for 2 common congenital heart defects with or without cyanosis. METHODS: We performed a prospective, double-blind, randomized controlled trial at 2 centers in the United Kingdom. Children aged 3 to 36 months undergoing tetralogy of Fallot repair or ventricular septal defect closure were randomized 1:1 to receive bilateral preconditioning or sham intervention...
April 2024: JTCVS open
https://read.qxmd.com/read/38662827/vitamin-d-regulates-microbiome-dependent-cancer-immunity
#2
JOURNAL ARTICLE
Evangelos Giampazolias, Mariana Pereira da Costa, Khiem C Lam, Kok Haw Jonathan Lim, Ana Cardoso, Cécile Piot, Probir Chakravarty, Sonja Blasche, Swara Patel, Adi Biram, Tomas Castro-Dopico, Michael D Buck, Richard R Rodrigues, Gry Juul Poulsen, Susana A Palma-Duran, Neil C Rogers, Maria A Koufaki, Carlos M Minutti, Pengbo Wang, Alexander Vdovin, Bruno Frederico, Eleanor Childs, Sonia Lee, Ben Simpson, Andrea Iseppon, Sara Omenetti, Gavin Kelly, Robert Goldstone, Emma Nye, Alejandro Suárez-Bonnet, Simon L Priestnall, James I MacRae, Santiago Zelenay, Kiran Raosaheb Patil, Kevin Litchfield, James C Lee, Tine Jess, Romina S Goldszmid, Caetano Reis E Sousa
A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D-induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of Bacteroides fragilis , which positively regulates cancer immunity...
April 26, 2024: Science
https://read.qxmd.com/read/38635183/interpersonal-supports-for-basic-psychological-needs-and-their-relations-with-motivation-well-being-and-performance-a-meta-analysis
#3
JOURNAL ARTICLE
Gavin R Slemp, James G Field, Richard M Ryan, Vivien W Forner, Anja Van den Broeck, Kelsey J Lewis
People's motivational processes, well-being, and performance are likely to be facilitated through the support of others. Self-determination theory argues that interpersonal supports for autonomy, competence, and relatedness are crucial to achieve these outcomes. In the present study, we provide a comprehensive examination of this formulation based on a meta-analytic database consisting of 4,561 effect sizes from 881 independent samples ( N = 443,556). Our results indicate that supports for autonomy, competence, and relatedness were strongly positively related with the satisfaction of these basic needs and strongly negatively related to their frustration...
April 18, 2024: Journal of Personality and Social Psychology
https://read.qxmd.com/read/38616041/disparities-in-prevalence-and-treatment-of-diabetes-cardiovascular-and-chronic-kidney-diseases-recommendations-from-the-taskforce-of-the-guideline-workshop
#4
JOURNAL ARTICLE
James R Gavin, Helena W Rodbard, Tadej Battelino, Frank Brosius, Antonio Ceriello, Francesco Cosentino, Francesco Giorgino, Jennifer Green, Linong Ji, Monika Kellerer, Susan Koob, Mikhail Kosiborod, Nebojsa Lalic, Nikolaus Marx, T Prashant Nedungadi, Christopher G Parkin, Pinar Topsever, Lars Rydén, Wayne Huey-Herng Sheu, Eberhard Standl, Per Olav Vandvik, Oliver Schnell
There is a mounting clinical, psychosocial, and socioeconomic burden worldwide as the prevalence of diabetes, cardiovascular disease (CVD), and chronic kidney disease (CKD) continues to rise. Despite the introduction of therapeutic interventions with demonstrated efficacy to prevent the development or progression of these common chronic diseases, many individuals have limited access to these innovations due to their race/ethnicity, and/or socioeconomic status (SES). However, practical guidance to providers and healthcare systems for addressing these disparities is often lacking...
April 12, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38605083/spatiotemporal-immune-atlas-of-a-clinical-grade-gene-edited-pig-to-human-kidney-xenotransplant
#5
JOURNAL ARTICLE
Matthew D Cheung, Rebecca Asiimwe, Elise N Erman, Christopher F Fucile, Shanrun Liu, Chiao-Wang Sun, Vidya Sagar Hanumanthu, Harish C Pal, Emma D Wright, Gelare Ghajar-Rahimi, Daniel Epstein, Babak J Orandi, Vineeta Kumar, Douglas J Anderson, Morgan E Greene, Markayla Bell, Stefani Yates, Kyle H Moore, Jennifer LaFontaine, John T Killian, Gavin Baker, Jackson Perry, Zayd Khan, Rhiannon Reed, Shawn C Little, Alexander F Rosenberg, James F George, Jayme E Locke, Paige M Porrett
Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it is unclear which immunomodulatory regimens will effectively control human immune responses to pig xenografts. Here, we transplant a gene-edited pig kidney into a brain-dead human recipient on pharmacologic immunosuppression and study the human immune response to the xenograft using spatial transcriptomics and single-cell RNA sequencing. Human immune cells are uncommon in the porcine kidney cortex early after xenotransplantation and consist of primarily myeloid cells...
April 11, 2024: Nature Communications
https://read.qxmd.com/read/38580072/flexible-modelling-of-the-dissolution-performance-of-directly-compressed-tablets
#6
JOURNAL ARTICLE
Natalie Maclean, John A Armstrong, Mark A Carroll, Mohammad Salehian, James Mann, Gavin Reynolds, Blair Johnston, Daniel Markl
In this study, a compartmental disintegration and dissolution model is proposed for the prediction and evaluation of the dissolution performance of directly compressed tablets. This dissolution model uses three compartments (Bound, Disintegrated, and Dissolved) to describe the state of each particle of active pharmaceutical ingredient. The disintegration of the tablet is captured by three fitting parameters. Two disintegration parameters, β0 and βt,0 , describe the initial disintegration rate and the change in disintegration rate, respectively...
April 3, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38573469/the-current-and-future-role-of-insulin-therapy-in-the-management-of-type-2-diabetes-a-narrative-review
#7
REVIEW
Janet B McGill, Irl B Hirsch, Christopher G Parkin, Grazia Aleppo, Carol J Levy, James R Gavin
Early initiation of intensive insulin therapy has been demonstrated to be effective in controlling glycemia and possibly preserving beta-cell function. Innovations in insulin formulations and delivery systems continue. However, we have seen an acceleration in the development of new classes of diabetes medications for individuals with type 2 diabetes and obesity, such as, for example, glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These formulations have been shown to confer significant benefits in achieving good glycemic control with reduced hypoglycemia risk, weight loss, and cardiorenal protection...
April 4, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38571388/clinical-outcomes-associated-with-diltiazem-use-in-heart-failure-with-reduced-ejection-fraction-after-implementation-of-a-clinical-support-system
#8
JOURNAL ARTICLE
Elizabeth M Foster, James C Coons, Elena A Puccio, Danine Sullinger, Rachel Ibrahim, Joseph Ibrahim, Gavin W Hickey, Edward Horn, Vincent Mosesso, Ryan M Rivosecchi
BACKGROUND: Despite atrial fibrillation guideline recommendations, many patients with heart failure with reduced ejection fraction (EF) continue to receive IV diltiazem for acute rate control. OBJECTIVE: Our institution recently implemented a clinical decision support system (CDSS)-based tool that recommends against the use of diltiazem in patients with an EF ≤ 40%. The objective of this study was to evaluate outcomes of adherence to the aforementioned CDSS-based tool...
April 3, 2024: Annals of Pharmacotherapy
https://read.qxmd.com/read/38532021/author-correction-2023-world-heart-federation-guidelines-for-the-echocardiographic-diagnosis-of-rheumatic-heart-disease
#9
Joselyn Rwebembera, James Marangou, Julius Chacha Mwita, Ana Olga Mocumbi, Cleonice Mota, Emmy Okello, Bruno Nascimento, Lene Thorup, Andrea Beaton, Joseph Kado, Alexander Kaethner, Raman Krishna Kumar, John Lawrenson, Eloi Marijon, Mariana Mirabel, Maria Carmo Pereira Nunes, Daniel Piñeiro, Fausto Pinto, Kate Ralston, Craig Sable, Amy Sanyahumbi, Anita Saxena, Karen Sliwa, Andrew Steer, Satupaitea Viali, Gavin Wheaton, Nigel Wilson, Liesl Zühlke, Bo Reményi
No abstract text is available yet for this article.
March 26, 2024: Nature Reviews. Cardiology
https://read.qxmd.com/read/38512960/covid-19-in-non-hospitalised-adults-caused-by-either-sars-cov-2-sub-variants-omicron-ba-1-ba-2-ba-4-5-or-delta-associates-with-similar-illness-duration-symptom-severity-and-viral-kinetics-irrespective-of-vaccination-history
#10
JOURNAL ARTICLE
Hermaleigh Townsley, Joshua Gahir, Timothy W Russell, David Greenwood, Edward J Carr, Matala Dyke, Lorin Adams, Murad Miah, Bobbi Clayton, Callie Smith, Mauro Miranda, Harriet V Mears, Chris Bailey, James R M Black, Ashley S Fowler, Margaret Crawford, Katalin Wilkinson, Matthew Hutchinson, Ruth Harvey, Nicola O'Reilly, Gavin Kelly, Robert Goldstone, Rupert Beale, Padmasayee Papineni, Tumena Corrah, Richard Gilson, Simon Caidan, Jerome Nicod, Steve Gamblin, George Kassiotis, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Adam J Kucharski, Charles Swanton, David L V Bauer, Emma C Wall
BACKGROUND: SARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought to characterise symptoms and viral loads over the course of COVID-19 infection with these sub-variants in otherwise-healthy, vaccinated, non-hospitalised adults, and compared data to infections with the preceding Delta variant of concern (VOC). METHODS: In a prospective, observational cohort study, healthy vaccinated UK adults who reported a positive polymerase chain reaction (PCR) or lateral flow test, self-swabbed on alternate weekdays until day 10...
2024: PloS One
https://read.qxmd.com/read/38507449/myosin-5-varies-its-step-length-to-carry-cargo-straight-along-the-irregular-f-actin-track
#11
JOURNAL ARTICLE
Adam Fineberg, Yasuharu Takagi, Kavitha Thirumurugan, Joanna Andrecka, Neil Billington, Gavin Young, Daniel Cole, Stan A Burgess, Alistair P Curd, John A Hammer, James R Sellers, Philipp Kukura, Peter J Knight
Molecular motors employ chemical energy to generate unidirectional mechanical output against a track while navigating a chaotic cellular environment, potential disorder on the track, and against Brownian motion. Nevertheless, decades of nanometer-precise optical studies suggest that myosin-5a, one of the prototypical molecular motors, takes uniform steps spanning 13 subunits (36 nm) along its F-actin track. Here, we use high-resolution interferometric scattering microscopy to reveal that myosin takes strides spanning 22 to 34 actin subunits, despite walking straight along the helical actin filament...
March 26, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38504015/neoadjuvant-nivolumab-or-nivolumab-plus-lag-3-inhibitor-relatlimab-in-resectable-esophageal-gastroesophageal-junction-cancer-a-phase-ib-trial-and-ctdna-analyses
#12
JOURNAL ARTICLE
Ronan J Kelly, Blair V Landon, Ali H Zaidi, Dipika Singh, Jenna V Canzoniero, Archana Balan, Russell K Hales, K Ranh Voong, Richard J Battafarano, Blair A Jobe, Stephen C Yang, Stephen Broderick, Jinny Ha, Kristen A Marrone, Gavin Pereira, Nisha Rao, Aryan Borole, Katerina Karaindrou, Zineb Belcaid, James R White, Suqi Ke, Ali I Amjad, Benny Weksler, Eun Ji Shin, Elizabeth Thompson, Kellie N Smith, Drew M Pardoll, Chen Hu, Josephine L Feliciano, Valsamo Anagnostou, Vincent K Lam
Gastroesophageal cancer dynamics and drivers of clinical responses with immune checkpoint inhibitors (ICI) remain poorly understood. Potential synergistic activity of dual programmed cell death protein 1 (PD-1) and lymphocyte-activation gene 3 (LAG-3) inhibition may help improve immunotherapy responses for these tumors. We report a phase Ib trial that evaluated neoadjuvant nivolumab (Arm A, n = 16) or nivolumab-relatlimab (Arm B, n = 16) in combination with chemoradiotherapy in 32 patients with resectable stage II/stage III gastroesophageal cancer together with an in-depth evaluation of pathological, molecular and functional immune responses...
March 19, 2024: Nature Medicine
https://read.qxmd.com/read/38502541/rsv-related-community-copd-exacerbations-and-novel-diagnostics-a-binational-prospective-cohort-study
#13
JOURNAL ARTICLE
Dexter J Wiseman, Ryan S Thwaites, Andrew I Ritchie, Lydia Finney, Mairi Macleod, Faisal Kamal, Hassan Shahbakhti, Lisa H van Smoorenburg, Huib A Kerstjens, Joanne Wildenbeest, Deniz Öner, Jeroen Aerssens, Guy Berbers, Rutger Schepp, Ashley Uruchurtu, Benedikt Ditz, Louis Bont, James P Allinson, Maarten van den Berge, Gavin C Donaldson, Peter J Openshaw, Jadwiga Wedzicha
RATIONALE: Respiratory syncytial virus (RSV) is a common global respiratory virus increasingly recognized as a major pathogen in frail older adults and as a cause of chronic obstructive pulmonary disease (COPD) exacerbations. There is no single test for RSV in adults with acceptable diagnostic accuracy. Trials of RSV vaccines have recently shown excellent safety and efficacy against RSV in older adults; defining the frequency of RSV-related community infections and COPD exacerbations is important for vaccine deployment decisions...
March 19, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38472701/factors-associated-with-increased-risk-of-postoperative-blood-transfusion-in-patients-undergoing-total-hip-arthroplasty-at-an-irish-university-hospital
#14
JOURNAL ARTICLE
Gavin David O'Connor, Stephen Mannion, James Purcell
INTRODUCTION: Approximately 7000 total hip arthroplasty (THA) surgeries occur in Ireland each year. A number of preoperative factors have been identified that increase the risk of postoperative blood transfusion after THA, including anaemia. The ability to identify patients at risk may allow preoperative management strategies to reduce blood transfusions. Data from Irish orthopaedic patients is currently lacking. AIM: To investigate if preoperative anaemia and other factors are associated with postoperative blood transfusions in patients who undergo THA...
March 12, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38453293/australian-national-standards-of-care-for-childhood-onset-heart-disease-cohd-standards-1st-edition
#15
JOURNAL ARTICLE
Gary F Sholler, Lisa A Selbie, Mary Tallon, Jessica Keating, Julian Ayer, Luke Burchill, Michael M H Cheung, Rachael Cordina, Evelyn Culnane, Shakira Donovan, Lucas Eastaugh, Caitlin Elliott, Jeffery Fletcher, Robert N Justo, Nadine A Kasparian, Andrew Kelly, Dominique Morsman, Mugur Nicolae, Yishay Orr, Elle Pendrick, James M Ramsay, Bo Reményi, Stephen Shipton, Robert G Weintraub, Elsa Van Wijk, Gavin Wheaton, Prem Venugopal
These first Australian National Standards of Care for Childhood-onset Heart Disease (CoHD Standards) have been developed to inform the healthcare requirements for CoHD services and enable all Australian patients, families and carers impacted by CoHD (paediatric CoHD and adult congenital heart disease [ACHD]) to live their best and healthiest lives. The CoHD Standards are designed to provide the clarity and certainty required for healthcare services to deliver excellent, comprehensive, inclusive, and equitable CoHD care across Australia for patients, families and carers, and offer an iterative roadmap to the future of these services...
February 2024: Heart, Lung & Circulation
https://read.qxmd.com/read/38437622/immunologic-predictors-of-vaccine-responsiveness-in-patients-with-lymphoma-and-cll
#16
JOURNAL ARTICLE
Elise A Chong, Kingsley Gideon Kumashie, Emeline R Chong, Joseph Fabrizio, Aditi Gupta, Jakub Svoboda, Stefan K Barta, Kristy M Walsh, Ellen B Napier, Rachel K Lundberg, Sunita D Nasta, James N Gerson, Daniel J Landsburg, Joyce Gonzalez, Andrew Gaano, Madison E Weirick, Christopher M McAllister, Moses Awofolaju, Gavin N John, Shane C Kammerman, Josef Novaceck, Raymone Pajarillo, Kendall A Lundgreen, Nicole Tanenbaum, Sigrid Gouma, Elizabeth M Drapeau, Sharon Adamski, Kurt D'Andrea, Ajinkya Pattekar, Amanda Hicks, Scott Korte, Harsh Sharma, Sarah Herring, Justine C Williams, Jacob T Hamilton, Paul Bates, Scott E Hensley, Eline T Luning Prak, Allison R Greenplate, E John Wherry, Stephen J Schuster, Marco Ruella, Laura A Vella
Patients with B-cell lymphomas have altered cellular components of vaccine responses due to malignancy and therapy, and the optimal timing of vaccination relative to therapy remains unknown. SARS-CoV-2 vaccines created an opportunity for new insights in vaccine timing because patients were challenged with a novel antigen across multiple phases of treatment. We studied serologic mRNA vaccine response in retrospective and prospective cohorts with lymphoma and CLL, paired with clinical and research immune parameters...
March 4, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38419116/tools-to-implement-measurement-based-care-mbc-in-the-treatment-of-opioid-use-disorder-oud-toward-a-consensus
#17
JOURNAL ARTICLE
A John Rush, Robert E Gore-Langton, Gavin Bart, Katharine A Bradley, Cynthia I Campbell, James McKay, David W Oslin, Andrew J Saxon, T John Winhusen, Li-Tzy Wu, Landhing M Moran, Betty Tai
BACKGROUND: The prevalence and associated overdose death rates from opioid use disorder (OUD) have dramatically increased in the last decade. Despite more available treatments than 20 years ago, treatment access and high discontinuation rates are challenges, as are personalized medication dosing and making timely treatment changes when treatments fail. In other fields such as depression, brief measures to address these tasks combined with an action plan-so-called measurement-based care (MBC)-have been associated with better outcomes...
February 28, 2024: Addiction Science & Clinical Practice
https://read.qxmd.com/read/38394591/achievement-of-target-gain-larger-than-unity-in-an-inertial-fusion-experiment
#18
JOURNAL ARTICLE
H Abu-Shawareb, R Acree, P Adams, J Adams, B Addis, R Aden, P Adrian, B B Afeyan, M Aggleton, L Aghaian, A Aguirre, D Aikens, J Akre, F Albert, M Albrecht, B J Albright, J Albritton, J Alcala, C Alday, D A Alessi, N Alexander, J Alfonso, N Alfonso, E Alger, S J Ali, Z A Ali, A Allen, W E Alley, P Amala, P A Amendt, P Amick, S Ammula, C Amorin, D J Ampleford, R W Anderson, T Anklam, N Antipa, B Appelbe, C Aracne-Ruddle, E Araya, T N Archuleta, M Arend, P Arnold, T Arnold, A Arsenlis, J Asay, L J Atherton, D Atkinson, R Atkinson, J M Auerbach, B Austin, L Auyang, A A S Awwal, N Aybar, J Ayers, S Ayers, T Ayers, S Azevedo, B Bachmann, C A Back, J Bae, D S Bailey, J Bailey, T Baisden, K L Baker, H Baldis, D Barber, M Barberis, D Barker, A Barnes, C W Barnes, M A Barrios, C Barty, I Bass, S H Batha, S H Baxamusa, G Bazan, J K Beagle, R Beale, B R Beck, J B Beck, M Bedzyk, R G Beeler, R G Beeler, W Behrendt, L Belk, P Bell, M Belyaev, J F Benage, G Bennett, L R Benedetti, L X Benedict, R L Berger, T Bernat, L A Bernstein, B Berry, L Bertolini, G Besenbruch, J Betcher, R Bettenhausen, R Betti, B Bezzerides, S D Bhandarkar, R Bickel, J Biener, T Biesiada, K Bigelow, J Bigelow-Granillo, V Bigman, R M Bionta, N W Birge, M Bitter, A C Black, R Bleile, D L Bleuel, E Bliss, E Bliss, B Blue, T Boehly, K Boehm, C D Boley, R Bonanno, E J Bond, T Bond, M J Bonino, M Borden, J-L Bourgade, J Bousquet, J Bowers, M Bowers, R Boyd, D Boyle, A Bozek, D K Bradley, K S Bradley, P A Bradley, L Bradley, L Brannon, P S Brantley, D Braun, T Braun, K Brienza-Larsen, R Briggs, T M Briggs, J Britten, E D Brooks, D Browning, M W Bruhn, T A Brunner, H Bruns, G Brunton, B Bryant, T Buczek, J Bude, L Buitano, S Burkhart, J Burmark, A Burnham, R Burr, L E Busby, B Butlin, R Cabeltis, M Cable, W H Cabot, B Cagadas, J Caggiano, R Cahayag, S E Caldwell, S Calkins, D A Callahan, J Calleja-Aguirre, L Camara, D Camp, E M Campbell, J H Campbell, B Carey, R Carey, K Carlisle, L Carlson, L Carman, J Carmichael, A Carpenter, C Carr, J A Carrera, D Casavant, A Casey, D T Casey, A Castillo, E Castillo, J I Castor, C Castro, W Caughey, R Cavitt, J Celeste, P M Celliers, C Cerjan, G Chandler, B Chang, C Chang, J Chang, L Chang, R Chapman, T D Chapman, L Chase, H Chen, H Chen, K Chen, L-Y Chen, B Cheng, J Chittenden, C Choate, J Chou, R E Chrien, M Chrisp, K Christensen, M Christensen, N S Christiansen, A R Christopherson, M Chung, J A Church, A Clark, D S Clark, K Clark, R Clark, L Claus, B Cline, J A Cline, J A Cobble, K Cochrane, B Cohen, S Cohen, M R Collette, G W Collins, L A Collins, T J B Collins, A Conder, B Conrad, M Conyers, A W Cook, D Cook, R Cook, J C Cooley, G Cooper, T Cope, S R Copeland, F Coppari, J Cortez, J Cox, D H Crandall, J Crane, R S Craxton, M Cray, A Crilly, J W Crippen, D Cross, M Cuneo, G Cuotts, C E Czajka, D Czechowicz, T Daly, P Danforth, C Danly, R Darbee, B Darlington, P Datte, L Dauffy, G Davalos, S Davidovits, P Davis, J Davis, S Dawson, R D Day, T H Day, M Dayton, C Deck, C Decker, C Deeney, K A DeFriend, G Deis, N D Delamater, J A Delettrez, R Demaret, S Demos, S M Dempsey, R Desjardin, T Desjardins, M P Desjarlais, E L Dewald, J DeYoreo, S Diaz, G Dimonte, T R Dittrich, L Divol, S N Dixit, J Dixon, A Do, E S Dodd, D Dolan, A Donovan, M Donovan, T Döppner, C Dorrer, N Dorsano, M R Douglas, D Dow, J Downie, E Downing, M Dozieres, V Draggoo, D Drake, R P Drake, T Drake, G Dreifuerst, O Drury, D F DuBois, P F DuBois, G Dunham, M Durocher, R Dylla-Spears, A K L Dymoke-Bradshaw, B Dzenitis, C Ebbers, M Eckart, S Eddinger, D Eder, D Edgell, M J Edwards, P Efthimion, J H Eggert, B Ehrlich, P Ehrmann, S Elhadj, C Ellerbee, N S Elliott, C L Ellison, F Elsner, M Emerich, K Engelhorn, T England, E English, P Epperson, R Epstein, G Erbert, M A Erickson, D J Erskine, A Erlandson, R J Espinosa, C Estes, K G Estabrook, S Evans, A Fabyan, J Fair, R Fallejo, N Farmer, W A Farmer, M Farrell, V E Fatherley, M Fedorov, E Feigenbaum, T Fehrenbach, M Feit, B Felker, W Ferguson, J C Fernandez, A Fernandez-Panella, S Fess, J E Field, C V Filip, J R Fincke, T Finn, S M Finnegan, R G Finucane, M Fischer, A Fisher, J Fisher, B Fishler, D Fittinghoff, P Fitzsimmons, M Flegel, K A Flippo, J Florio, J Folta, P Folta, L R Foreman, C Forrest, A Forsman, J Fooks, M Foord, R Fortner, K Fournier, D E Fratanduono, N Frazier, T Frazier, C Frederick, M S Freeman, J Frenje, D Frey, G Frieders, S Friedrich, D H Froula, J Fry, T Fuller, J Gaffney, S Gales, B Le Galloudec, K K Le Galloudec, A Gambhir, L Gao, W J Garbett, A Garcia, C Gates, E Gaut, P Gauthier, Z Gavin, J Gaylord, C G R Geddes, M Geissel, F Génin, J Georgeson, H Geppert-Kleinrath, V Geppert-Kleinrath, N Gharibyan, J Gibson, C Gibson, E Giraldez, V Glebov, S G Glendinning, S Glenn, S H Glenzer, S Goade, P L Gobby, S R Goldman, B Golick, M Gomez, V Goncharov, D Goodin, P Grabowski, E Grafil, P Graham, J Grandy, E Grasz, F R Graziani, G Greenman, J A Greenough, A Greenwood, G Gregori, T Green, J R Griego, G P Grim, J Grondalski, S Gross, J Guckian, N Guler, B Gunney, G Guss, S Haan, J Hackbarth, L Hackel, R Hackel, C Haefner, C Hagmann, K D Hahn, S Hahn, B J Haid, B M Haines, B M Hall, C Hall, G N Hall, M Hamamoto, S Hamel, C E Hamilton, B A Hammel, J H Hammer, G Hampton, A Hamza, A Handler, S Hansen, D Hanson, R Haque, D Harding, E Harding, J D Hares, D B Harris, J A Harte, E P Hartouni, R Hatarik, S Hatchett, A A Hauer, M Havre, R Hawley, J Hayes, J Hayes, S Hayes, A Hayes-Sterbenz, C A Haynam, D A Haynes, D Headley, A Heal, J E Heebner, S Heerey, G M Heestand, R Heeter, N Hein, C Heinbockel, C Hendricks, M Henesian, J Heninger, J Henrikson, E A Henry, E B Herbold, M R Hermann, G Hermes, J E Hernandez, V J Hernandez, M C Herrmann, H W Herrmann, O D Herrera, D Hewett, R Hibbard, D G Hicks, D P Higginson, D Hill, K Hill, T Hilsabeck, D E Hinkel, D D Ho, V K Ho, J K Hoffer, N M Hoffman, M Hohenberger, M Hohensee, W Hoke, D Holdener, F Holdener, J P Holder, B Holko, D Holunga, J F Holzrichter, J Honig, D Hoover, D Hopkins, L F Berzak Hopkins, M Hoppe, M L Hoppe, J Horner, R Hornung, C J Horsfield, J Horvath, D Hotaling, R House, L Howell, W W Hsing, S X Hu, H Huang, J Huckins, H Hui, K D Humbird, J Hund, J Hunt, O A Hurricane, M Hutton, K H-K Huynh, L Inandan, C Iglesias, I V Igumenshchev, I Ivanovich, N Izumi, M Jackson, J Jackson, S D Jacobs, G James, K Jancaitis, J Jarboe, L C Jarrott, D Jasion, J Jaquez, J Jeet, A E Jenei, J Jensen, J Jimenez, R Jimenez, D Jobe, Z Johal, H M Johns, D Johnson, M A Johnson, M Gatu Johnson, R J Johnson, S Johnson, S A Johnson, T Johnson, K Jones, O Jones, M Jones, R Jorge, H J Jorgenson, M Julian, B I Jun, R Jungquist, J Kaae, N Kabadi, D Kaczala, D Kalantar, K Kangas, V V Karasiev, M Karasik, V Karpenko, A Kasarky, K Kasper, R Kauffman, M I Kaufman, C Keane, L Keaty, L Kegelmeyer, P A Keiter, P A Kellett, J Kellogg, J H Kelly, S Kemic, A J Kemp, G E Kemp, G D Kerbel, D Kershaw, S M Kerr, T J Kessler, M H Key, S F Khan, H Khater, C Kiikka, J Kilkenny, Y Kim, Y-J Kim, J Kimko, M Kimmel, J M Kindel, J King, R K Kirkwood, L Klaus, D Klem, J L Kline, J Klingmann, G Kluth, P Knapp, J Knauer, J Knipping, M Knudson, D Kobs, J Koch, T Kohut, C Kong, J M Koning, P Koning, S Konior, H Kornblum, L B Kot, B Kozioziemski, M Kozlowski, P M Kozlowski, J Krammen, N S Krasheninnikova, C M Krauland, B Kraus, W Krauser, J D Kress, A L Kritcher, E Krieger, J J Kroll, W L Kruer, M K G Kruse, S Kucheyev, M Kumbera, S Kumpan, J Kunimune, E Kur, B Kustowski, T J T Kwan, G A Kyrala, S Laffite, M Lafon, K LaFortune, L Lagin, B Lahmann, B Lairson, O L Landen, T Land, M Lane, D Laney, A B Langdon, J Langenbrunner, S H Langer, A Langro, N E Lanier, T E Lanier, D Larson, B F Lasinski, D Lassle, D LaTray, G Lau, N Lau, C Laumann, A Laurence, T A Laurence, J Lawson, H P Le, R R Leach, L Leal, A Leatherland, K LeChien, B Lechleiter, A Lee, M Lee, T Lee, R J Leeper, E Lefebvre, J-P Leidinger, B LeMire, R W Lemke, N C Lemos, S Le Pape, R Lerche, S Lerner, S Letts, K Levedahl, T Lewis, C K Li, H Li, J Li, W Liao, Z M Liao, D Liedahl, J Liebman, G Lindford, E L Lindman, J D Lindl, H Loey, R A London, F Long, E N Loomis, F E Lopez, H Lopez, E Losbanos, S Loucks, R Lowe-Webb, E Lundgren, A P Ludwigsen, R Luo, J Lusk, R Lyons, T Ma, Y Macallop, M J MacDonald, B J MacGowan, J M Mack, A J Mackinnon, S A MacLaren, A G MacPhee, G R Magelssen, J Magoon, R M Malone, T Malsbury, R Managan, R Mancini, K Manes, D Maney, D Manha, O M Mannion, A M Manuel, M J-E Manuel, E Mapoles, G Mara, T Marcotte, E Marin, M M Marinak, D A Mariscal, E F Mariscal, E V Marley, J A Marozas, R Marquez, C D Marshall, F J Marshall, M Marshall, S Marshall, J Marticorena, J I Martinez, D Martinez, I Maslennikov, D Mason, R J Mason, L Masse, W Massey, P-E Masson-Laborde, N D Masters, D Mathisen, E Mathison, J Matone, M J Matthews, C Mattoon, T R Mattsson, K Matzen, C W Mauche, M Mauldin, T McAbee, M McBurney, T Mccarville, R L McCrory, A M McEvoy, C McGuffey, M Mcinnis, P McKenty, M S McKinley, J B McLeod, A McPherson, B Mcquillan, M Meamber, K D Meaney, N B Meezan, R Meissner, T A Mehlhorn, N C Mehta, J Menapace, F E Merrill, B T Merritt, E C Merritt, D D Meyerhofer, S Mezyk, R J Mich, P A Michel, D Milam, C Miller, D Miller, D S Miller, E Miller, E K Miller, J Miller, M Miller, P E Miller, T Miller, W Miller, V Miller-Kamm, M Millot, J L Milovich, P Minner, J-L Miquel, S Mitchell, K Molvig, R C Montesanti, D S Montgomery, M Monticelli, A Montoya, J D Moody, A S Moore, E Moore, M Moran, J C Moreno, K Moreno, B E Morgan, T Morrow, J W Morton, E Moses, K Moy, R Muir, M S Murillo, J E Murray, J R Murray, D H Munro, T J Murphy, F M Munteanu, J Nafziger, T Nagayama, S R Nagel, R Nast, R A Negres, A Nelson, D Nelson, J Nelson, S Nelson, S Nemethy, P Neumayer, K Newman, M Newton, H Nguyen, J-M G Di Nicola, P Di Nicola, C Niemann, A Nikroo, P M Nilson, A Nobile, V Noorai, R C Nora, M Norton, M Nostrand, V Note, S Novell, P F Nowak, A 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Procassini, A Pruyne, B Pudliner, S R Qiu, K Quan, M Quinn, J Quintenz, P B Radha, F Rainer, J E Ralph, K S Raman, R Raman, P W Rambo, S Rana, A Randewich, D Rardin, M Ratledge, N Ravelo, F Ravizza, M Rayce, A Raymond, B Raymond, B Reed, C Reed, S Regan, B Reichelt, V Reis, S Reisdorf, V Rekow, B A Remington, A Rendon, W Requieron, M Rever, H Reynolds, J Reynolds, J Rhodes, M Rhodes, M C Richardson, B Rice, N G Rice, R Rieben, A Rigatti, S Riggs, H G Rinderknecht, K Ring, B Riordan, R Riquier, C Rivers, D Roberts, V Roberts, G Robertson, H F Robey, J Robles, P Rocha, G Rochau, J Rodriguez, S Rodriguez, M D Rosen, M Rosenberg, G Ross, J S Ross, P Ross, J Rouse, D Rovang, A M Rubenchik, M S Rubery, C L Ruiz, M Rushford, B Russ, J R Rygg, B S Ryujin, R A Sacks, R F Sacks, K Saito, T Salmon, J D Salmonson, J Sanchez, S Samuelson, M Sanchez, C Sangster, A Saroyan, J Sater, A Satsangi, S Sauers, R Saunders, J P Sauppe, R Sawicki, D Sayre, M Scanlan, K Schaffers, G T Schappert, S Schiaffino, 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X Vu, M Vu, D Wall, J Wall, R Wallace, B Wallin, D Walmer, C A Walsh, C F Walters, C Waltz, A Wan, A Wang, Y Wang, J S Wark, B E Warner, J Watson, R G Watt, P Watts, J Weaver, R P Weaver, S Weaver, C R Weber, P Weber, S V Weber, P Wegner, B Welday, L Welser-Sherrill, K Weiss, K B Wharton, G F Wheeler, W Whistler, R K White, H D Whitley, P Whitman, M E Wickett, K Widmann, C Widmayer, J Wiedwald, R Wilcox, S Wilcox, C Wild, B H Wilde, C H Wilde, K Wilhelmsen, M D Wilke, H Wilkens, P Wilkins, S C Wilks, E A Williams, G J Williams, W Williams, W H Williams, D C Wilson, B Wilson, E Wilson, R Wilson, S Winters, P J Wisoff, M Wittman, J Wolfe, A Wong, K W Wong, L Wong, N Wong, R Wood, D Woodhouse, J Woodruff, D T Woods, S Woods, B N Woodworth, E Wooten, A Wootton, K Work, J B Workman, J Wright, M Wu, C Wuest, F J Wysocki, H Xu, M Yamaguchi, B Yang, S T Yang, J Yatabe, C B Yeamans, B C Yee, S A Yi, L Yin, B Young, C S Young, C V Young, P Young, K Youngblood, J Yu, R Zacharias, G Zagaris, N Zaitseva, F Zaka, F Ze, B Zeiger, M Zika, G B Zimmerman, T Zobrist, J D Zuegel, A B Zylstra
On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys...
February 9, 2024: Physical Review Letters
https://read.qxmd.com/read/38387567/polychlorinated-dibenzodioxins-furans-and-dioxin-like-polychlorinated-biphenyls-s-in-fish-and-crustaceans-of-a-recreationally-fished-estuary-following-targeted-remediation
#19
JOURNAL ARTICLE
Matthew D Taylor, Kate A Langdon, James A Smith, Gavin Stevenson, Katelyn Edge
Polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) are a suite of harmful chemicals (hereafter collectively referred to as 'dioxins'), and their emission into aquatic habitats leads to persistent contamination of sediments, aquatic food-webs, and seafoods. Quantifying contaminant levels in seafood species is important for the ongoing management of exposure risk by fishers, particularly after any remediation actions. We present dioxin concentrations in four seafood species (Yellowfin Bream Acanthopagrus australis, Sea Mullet Mugil cephalus, Eastern School Prawn Metapenaeus macleayi, and Eastern King Prawn Penaeus plebejus) in a recreationally fished estuary, in relation to a contaminated site that has undergone a remediation process, partially removing contaminated sediments (Homebush Bay, Port Jackson, New South Wales, Australia)...
February 20, 2024: Science of the Total Environment
https://read.qxmd.com/read/38357931/a-metabolic-signature-for-nadsyn1-dependent-congenital-nad-deficiency-disorder
#20
JOURNAL ARTICLE
Justin O Szot, Hartmut Cuny, Ella Mma Martin, Delicia Z Sheng, Kavitha Iyer, Stephanie Portelli, Vivien Nguyen, Jessica M Gereis, Dimuthu Alankarage, David Chitayat, Karen Chong, Ingrid M Wentzensen, Catherine Vincent-Delormé, Alban Lermine, Emma Burkitt-Wright, Weizhen Ji, Lauren Jeffries, Lynn S Pais, Tiong Y Tan, James Pitt, Cheryl A Wise, Helen Wright, Israel D Andrews, Brianna Pruniski, Theresa A Grebe, Nicole Corsten-Janssen, Katelijne Bouman, Cathryn Poulton, Supraja Prakash, Boris Keren, Natasha J Brown, Matthew F Hunter, Oliver Heath, Saquib A Lakhani, John H McDermott, David B Ascher, Gavin Chapman, Kayleigh Bozon, Sally L Dunwoodie
Nicotinamide adenine dinucleotide (NAD) is essential for embryonic development. To date, biallelic loss-of-function variants in 3 genes encoding nonredundant enzymes of the NAD de novo synthesis pathway - KYNU, HAAO, and NADSYN1 - have been identified in humans with congenital malformations defined as congenital NAD deficiency disorder (CNDD). Here, we identified 13 further individuals with biallelic NADSYN1 variants predicted to be damaging, and phenotypes ranging from multiple severe malformations to the complete absence of malformation...
February 15, 2024: Journal of Clinical Investigation
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