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https://www.readbyqxmd.com/read/28629897/a-unified-pathophysiological-construct-of-diabetes-and-its-complications
#1
REVIEW
Stanley S Schwartz, Solomon Epstein, Barbara E Corkey, Struan F A Grant, James R Gavin Iii, Richard B Aguilar, Mary E Herman
Advances in understanding diabetes mellitus (DM) through basic and clinical research have helped clarify and reunify a disease state fragmented into numerous etiologies and subtypes. It is now understood that a common pathophysiology drives the diabetic state throughout its natural history and across its varied clinical presentations, a pathophysiology involving metabolic insults, oxidative damage, and vicious cycles that aggravate and intensify organ dysfunction and damage. This new understanding of the disease requires that we revisit existing diagnostics and treatment approaches, which were built upon outmoded assumptions...
June 16, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28611135/a-rare-testicular-vein-anatomical-variant-contributes-to-right-sided-varicocoele-formation-and-leads-to-the-diagnosis-of-renal-cell-carcinoma
#2
James William Ryan, Gavin Sugrue, Sandra Graham, Carmel Cronin
No abstract text is available yet for this article.
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28586915/specific-alleles-of-cln7-mfsd8-a-protein-that-localizes-to-photoreceptor-synaptic-terminals-cause-a-spectrum-of-nonsyndromic-retinal-dystrophy
#3
Kamron N Khan, Mohammed E El-Asrag, Cristy A Ku, Graham E Holder, Martin McKibbin, Gavin Arno, James A Poulter, Keren Carss, Tejaswi Bommireddy, Saghar Bagheri, Benjamin Bakall, Hendrik P Scholl, F Lucy Raymond, Carmel Toomes, Chris F Inglehearn, Mark E Pennesi, Anthony T Moore, Michel Michaelides, Andrew R Webster, Manir Ali
Purpose: Recessive mutations in CLN7/MFSD8 usually cause variant late-infantile onset neuronal ceroid lipofuscinosis (vLINCL), a poorly understood neurodegenerative condition, though mutations may also cause nonsyndromic maculopathy. A series of 12 patients with nonsyndromic retinopathy due to novel CLN7/MFSD8 mutation combinations were investigated in this study. Methods: Affected patients and their family members were recruited in ophthalmic clinics at each center where they were examined by retinal imaging and detailed electrophysiology...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28579374/activated-plasmacytoid-dendritic-cells-regulate-type-2-innate-lymphoid-cells-mediated-airway-hyperreactivity
#4
Hadi Maazi, Homayon Banie, German Aleman, Nisheel Patel, Bowen Wang, Ishwarya Sankaranarayanan, Vipul Bhargava, Takahiro Sato, Gavin Lewis, Matteo Cesaroni, James Karras, Anuk Das, Pejman Soroosh, Omid Akbari
BACKGROUND: Allergic asthma is a prevalent inflammatory disease of the airways caused by dysregulated immune balance in the lungs with incompletely understood pathogenesis. The recently identified type 2 innate lymphoid cells (ILC2s) play significant roles in the pathogenesis of asthma. While ILC2-activating factors have been identified, the mechanisms that suppress ILC2s remain largely unknown. Plasmacytoid dendritic cells, pDCs, are important in antiviral immunity and in maintaining tolerance to inert antigens...
June 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28541135/clinical-use-of-professional-continuous-glucose-monitoring
#5
Eugene E Wright, James R Gavin
No abstract text is available yet for this article.
May 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28538446/coaching-the-debriefer-peer-coaching-to-improve-debriefing-quality-in-simulation-programs
#6
Adam Cheng, Vincent Grant, James Huffman, Gavin Burgess, Demian Szyld, Traci Robinson, Walter Eppich
Formal faculty development programs for simulation educators are costly and time-consuming. Peer coaching integrated into the teaching flow can enhance an educator's debriefing skills. We provide a practical guide for the who, what, when, where, why, and how of peer coaching for debriefing in simulation-based education. Peer coaching offers advantages such as psychological safety and team building, and it can benefit both the educator who is receiving feedback and the coach who is providing it. A feedback form for effective peer coaching includes the following: (1) psychological safety, (2) framework, (3) method/strategy, (4) content, (5) learner centeredness, (6) co-facilitation, (7) time management, (8) difficult situations, (9) debriefing adjuncts, and (10) individual style and experience...
May 20, 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28530117/combined-impact-of-smoking-and-early-life-exposures-on-adult-lung-function-trajectories
#7
James P Allinson, Rebecca Hardy, Gavin C Donaldson, Seif O Shaheen, Diana Kuh, Jadwiga A Wedzicha
BACKGROUND: Both adverse early life exposures and adult smoking can negatively influence adult lung function trajectory but few studies consider how the impact of early life exposures may be modified by subsequent smoking. METHODS: The Medical Research Council National Survey of Health and Development is a nationally representative cohort, initially of 5362 individuals, followed since enrolment at birth in March 1946. Using data collected prospectively across life and multilevel modelling we investigated how the relationships between early life exposures (infant lower respiratory infection, manual social class, home overcrowding and pollution exposure) and FEV1 and FVC trajectories between ages 43 and 60-64 were influenced by smoking behaviour...
May 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28524155/statin-use-candidate-mevalonate-pathway-biomarkers-and-colon-cancer-survival-in-a-population-based-cohort-study
#8
Ronan T Gray, Maurice B Loughrey, Peter Bankhead, Chris R Cardwell, Stephen McQuaid, Roisin F O'Neill, Kenneth Arthur, Victoria Bingham, Claire McGready, Anna T Gavin, Jacqueline A James, Peter W Hamilton, Manuel Salto-Tellez, Liam J Murray, Helen G Coleman
BACKGROUND: Statin use after colorectal cancer diagnosis may improve survival but evidence from observational studies is conflicting. The anti-cancer effect of statins may be restricted to certain molecular subgroups. In this population-based cohort study, the interaction between p53 and 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGCR) expression, KRAS mutations, and the association between statin use and colon cancer survival was assessed. METHODS: The cohort consisted of 740 stage II and III colon cancer patients diagnosed between 2004 and 2008...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28512701/estimation-of-3d-ground-reaction-force-using-nanocomposite-piezo-responsive-foam-sensors-during-walking
#9
Parker G Rosquist, Gavin Collins, A Jake Merrell, Noelle J Tuttle, James B Tracy, Evan T Bird, Matthew K Seeley, David T Fullwood, William F Christensen, Anton E Bowden
This paper describes a method for the estimation of the 3D ground reaction force (GRF) during human walking using novel nanocomposite piezo-responsive foam (NCPF) sensors. Nine subjects (5 male, 4 female) walked on a force-instrumented treadmill at 1.34 m/s for 120 s each while wearing a shoe that was instrumented with four NCPF sensors. GRF data, measured via the treadmill, and sensor data, measured via the NCPF inserts, were used in a tenfold cross validation process to calibrate a separate model for each individual...
May 16, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28474861/group-2-innate-lymphoid-cells-are-elevated-and-activated-in-chronic-rhinosinusitis-with-nasal-polyps
#10
Julie A Poposki, Aiko I Klingler, Bruce K Tan, Pejman Soroosh, Homayon Banie, Gavin Lewis, Kathryn E Hulse, Whitney W Stevens, Anju T Peters, Leslie C Grammer, Robert P Schleimer, Kevin C Welch, Stephanie S Smith, David B Conley, Joseph R Raviv, James G Karras, Omid Akbari, Robert C Kern, Atsushi Kato
BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is characterized by type 2 inflammation with high levels of Th2 cytokines. Although T helper cytokines are released from T cells, innate lymphoid cells (ILC) are also known to produce high levels of the same cytokines. However, the presence of various types of ILC in CRS is poorly understood. OBJECTIVE: The objective of this study was to fully characterize the presence of all ILC subsets in CRS and to identify phenotypical differences of group 2 ILC (ILC2) in CRSwNP compared to ILC2 from non-type 2 inflamed areas...
April 19, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28473708/optical-coherence-tomography-based-contact%C3%A2-indentation%C3%A2-for-diaphragm-mechanics-in-a-mouse-model-of-transforming-growth-factor-alpha-induced-lung-disease
#11
Kimberley C W Wang, Chrissie J Astell, Philip Wijesinghe, Alexander N Larcombe, Gavin J Pinniger, Graeme R Zosky, Brendan F Kennedy, Luke J Berry, David D Sampson, Alan L James, Timothy D Le Cras, Peter B Noble
This study tested the utility of optical coherence tomography (OCT)-based indentation to assess mechanical properties of respiratory tissues in disease. Using OCT-based indentation, the elastic modulus of mouse diaphragm was measured from changes in diaphragm thickness in response to an applied force provided by an indenter. We used a transgenic mouse model of chronic lung disease induced by the overexpression of transforming growth factor-alpha (TGF-α), established by the presence of pleural and peribronchial fibrosis and impaired lung mechanics determined by the forced oscillation technique and plethysmography...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28460465/functional-characterisation-of-a-novel-ovarian-cancer-cell-line-nuoc-1
#12
Aiste McCormick, Eleanor Earp, Katherine Elliot, Gavin Cuthbert, Rachel O'Donnell, Brian T Wilson, Ruth Sutton, Charlotte Leeson, Huw D Thomas, Helen Blair, Sarah Fordham, John Lunec, James Allan, Richard J Edmondson
BACKGROUND: Cell lines provide a powerful model to study cancer and here we describe a new spontaneously immortalised epithelial ovarian cancer cell line (NUOC-1) derived from the ascites collected at a time of primary debulking surgery for a mixed endometrioid / clear cell / High Grade Serous (HGS) histology. RESULTS: This spontaneously immortalised cell line was found to maintain morphology and epithelial markers throughout long-term culture. NUOC-1 cells grow as an adherent monolayer with a doubling time of 58 hours...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28448072/evaluation-of-ptgs2-expression-pik3ca-mutation-aspirin-use-and-colon-cancer-survival-in-a-population-based-cohort-study
#13
Ronan T Gray, Marie M Cantwell, Helen G Coleman, Maurice B Loughrey, Peter Bankhead, Stephen McQuaid, Roisin F O'Neill, Kenneth Arthur, Victoria Bingham, Claire McGready, Anna T Gavin, Chris R Cardwell, Brian T Johnston, Jacqueline A James, Peter W Hamilton, Manuel Salto-Tellez, Liam J Murray
OBJECTIVES: The association between aspirin use and improved survival after colorectal cancer diagnosis may be more pronounced in tumors that have PIK3CA mutations or high PTGS2 expression. However, the evidence of a difference in association by biomarker status lacks consistency. In this population-based colon cancer cohort study the interaction between these biomarkers, aspirin use, and survival was assessed. METHODS: The cohort consisted of 740 stage II and III colon cancer patients diagnosed between 2004 and 2008...
April 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28446457/consensus-statement-on-concussion-in-sport-the-5-th-international-conference-on-concussion-in-sport-held-in-berlin-october-2016
#14
Paul McCrory, Willem Meeuwisse, Jiří Dvorak, Mark Aubry, Julian Bailes, Steven Broglio, Robert C Cantu, David Cassidy, Ruben J Echemendia, Rudy J Castellani, Gavin A Davis, Richard Ellenbogen, Carolyn Emery, Lars Engebretsen, Nina Feddermann-Demont, Christopher C Giza, Kevin M Guskiewicz, Stanley Herring, Grant L Iverson, Karen M Johnston, James Kissick, Jeffrey Kutcher, John J Leddy, David Maddocks, Michael Makdissi, Geoff T Manley, Michael McCrea, William P Meehan, Sinji Nagahiro, Jon Patricios, Margot Putukian, Kathryn J Schneider, Allen Sills, Charles H Tator, Michael Turner, Pieter E Vos
No abstract text is available yet for this article.
April 26, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28446453/the-sport-concussion-assessment-tool-5th-edition-scat5
#15
Ruben J Echemendia, Willem Meeuwisse, Paul McCrory, Gavin A Davis, Margot Putukian, John Leddy, Michael Makdissi, S John Sullivan, Steven P Broglio, Martin Raftery, Kathryn Schneider, James Kissick, Michael McCrea, Jiri Dvorak, Allen K Sills, Mark Aubry, Lars Engebretsen, Mike Loosemore, Gordon Fuller, Jeffrey Kutcher, Richard Ellenbogen, Kevin Guskiewicz, Jon Patricios, Stanley Herring
This paper presents the Sport Concussion Assessment Tool 5th Edition (SCAT5), which is the most recent revision of a sport concussion evaluation tool for use by healthcare professionals in the acute evaluation of suspected concussion. The revision of the SCAT3 (first published in 2013) culminated in the SCAT5. The revision was based on a systematic review and synthesis of current research, public input and expert panel review as part of the 5th International Consensus Conference on Concussion in Sport held in Berlin in 2016...
April 26, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28446450/the-concussion-recognition-tool-5th-edition-crt5
#16
Ruben J Echemendia, Willem Meeuwisse, Paul McCrory, Gavin A Davis, Margot Putukian, John Leddy, Michael Makdissi, S John Sullivan, Steven P Broglio, Martin Raftery, Kathryn Schneider, James Kissick, Michael McCrea, Jiri Dvorak, Allen K Sills, Mark Aubry, Lars Engebretsen, Mike Lossemore, Gordon Fuller, Jeffrey Kutcher, Richard Ellenbogen, Kevin Guskiewicz, Jon Patricios, Stanley Herring
The Concussion Recognition Tool 5 (CRT5) is the most recent revision of the Pocket Sport Concussion Assessment Tool 2 that was initially introduced by the Concussion in Sport Group in 2005. The CRT5 is designed to assist non-medically trained individuals to recognise the signs and symptoms of possible sport-related concussion and provides guidance for removing an athlete from play/sport and to seek medical attention. This paper presents the development of the CRT5 and highlights the differences between the CRT5 and prior versions of the instrument...
April 26, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28445073/plasminogen-activator-inhibitor-1-is-critical-in-alcohol-enhanced-acute-lung-injury-in-mice
#17
Lauren G Poole, Veronica L Massey, Deanna L Siow, Edilson Torres-González, Nikole L Warner, James P Luyendyk, Jeffrey D Ritzenthaler, Jesse Roman, Gavin E Arteel
RATIONALE: Chronic alcohol exposure is a clinically important risk factor for development of acute respiratory distress syndrome, the most severe form of acute lung injury (ALI). However, the mechanisms by which alcohol sensitizes the lung to development of this disease are poorly understood. OBJECTIVES: We determined the role of the anti-fibrinolytic protein plasminogen activator inhibitor-1 (PAI-1) in alcohol enhancement of experimental endotoxin-induced ALI. METHODS: Wild-type (WT), PAI-1(-/-) and Integrin β3(-/-) mice were fed ethanol-containing Lieber-DeCarli liquid or control diet for 6 weeks followed by systemic lipopolysaccharide (LPS) challenge...
April 26, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28423771/disentangling-prognostic-and-predictive-biomarkers-through-mutual-information
#18
Konstantinos Sechidis, Emily Turner, Paul Metcalfe, James Weatherall, Gavin Brown
We study information theoretic methods for ranking biomarkers. In clinical trials, there are two, closely related, types of biomarkers: predictive and prognostic, and disentangling them is a key challenge. Our first step is to phrase biomarker ranking in terms of optimizing an information theoretic quantity. This formalization of the problem will enable us to derive rankings of predictive/prognostic biomarkers, by estimating different, high dimensional, conditional mutual information terms. To estimate these terms, we suggest efficient low dimensional approximations...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28368672/idarubicin-dose-escalation-during-consolidation-therapy-for-adult-acute-myeloid-leukemia
#19
Kenneth F Bradstock, Emma Link, Juliana Di Iulio, Jeff Szer, Paula Marlton, Andrew H Wei, Arno Enno, Anthony Schwarer, Ian D Lewis, James D'Rozario, Luke Coyle, Gavin Cull, Phillip Campbell, Michael F Leahy, Uwe Hahn, Paul Cannell, Campbell Tiley, Ray M Lowenthal, John Moore, Kimberly Cartwright, Ilona Cunningham, John Taper, Andrew Grigg, Andrew W Roberts, Warwick Benson, Mark Hertzberg, Sandra Deveridge, Philip Rowlings, Anthony K Mills, Devinder Gill, Peter Bardy, Lynda Campbell, John F Seymour
Purpose Higher doses of the anthracycline daunorubicin during induction therapy for acute myeloid leukemia (AML) have been shown to improve remission rates and survival. We hypothesized that improvements in outcomes in adult AML may be further achieved by increased anthracycline dose during consolidation therapy. Patients and Methods Patients with AML in complete remission after induction therapy were randomly assigned to receive two cycles of consolidation therapy with cytarabine 100 mg/m(2) daily for 5 days, etoposide 75 mg/m(2) daily for 5 days, and idarubicin 9 mg/m(2) daily for either 2 or 3 days (standard and intensive arms, respectively)...
May 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28365628/the-latest-national-clinical-guideline-for-stroke
#20
Anthony George Rudd, Audrey Bowen, Gavin R Young, Martin A James
No abstract text is available yet for this article.
April 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
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