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https://www.readbyqxmd.com/read/28098663/adenosquamous-carcinoma-of-the-pancreas-demonstrated-on-18f-fdg-pet-ct-imaging
#1
Lei Jiang, Hongting Nie, Lei Zhu, Yan Xiu, Hongcheng Shi
A 69-year-old woman had gradually worsening abdominal discomfort over a year. A pancreatic mass was revealed by abdominal CT. The patient underwent FDG PET/CT for staging, which demonstrated the hypermetabolic pancreatic mass with multiple liver metastases. The lesion was pathologically confirmed as pancreatic adenosquamous carcinoma after biopsy.
January 16, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28098572/metastatic-organotropism-an-intrinsic-property-of-breast-cancer-molecular-subtypes
#2
Shi Wei, Gene P Siegal
It has long been known that some cancers have the propensity to metastasize to certain organs thus creating a nonrandom distribution of sites for distant relapse, a phenomenon known as "metastatic organotropism." Some of these examples include ovary primary to abdominal cavity, prostate primary to bone, and pancreas primary to liver. In contrast, other tumor types, such as mammary and renal cell carcinoma, can relapse in multiple organs although approximately half of advanced breast cancers metastasize to bone...
January 16, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28098112/autosomal-dominant-polycystic-kidney-disease-study-of-clinical-characteristics-in-an-indian-population
#3
Sanjay Vikrant, Anupam Parashar
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary form of kidney disease. Clinical data on this multisystem disorder are scarce from developing countries. We conducted a prospective observational study of the clinical profile of ADPKD patients at a single center over a period of six years. A total of 208 patients were studied. Majority were male (60.6%) and the mean age was 45.8 ± 14.5 years. About 61.5% had early stage (Stages 1-3) of chronic kidney disease (CKD) and 38.5% had advanced CKD (Stages 4 and 5)...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28094661/diagnosis-of-pancreatic-disease-in-feline-platynosomosis
#4
Liza S Köster, Linda Shell, Jennifer Ketzis, Sreekumari Rajeev, Oscar Illanes
Objectives Platynosomum species are cat-specific parasitic trematodes that parasitize the biliary ducts and gall bladder. Due to the common connection to the major duodenal papilla of the pancreas and common bile ducts in addition to the periductal proximity of the pancreas, it is possible that platynosomosis could cause pancreatitis. The objective of this study was to determine whether platynosomosis, a commonly diagnosed parasitic disease in cats on St Kitts, has any association with pancreatic disease. Methods To investigate this possibility, the pancreas of free-roaming cats with naturally acquired platynosomosis were evaluated via ultrasound, serum concentrations of feline pancreatic lipase (fPL), cobalamin, folate and feline trypsin-like immunoreactivity (fTLI) and histopathology...
January 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28094052/the-association-of-cancer-risks-with-pentachlorophenol-exposure-focusing-on-community-population-in-the-areas-along-certain-section-of-yangtze-river-in-china
#5
Yanjie Cui, Ling Liang, Qi Zhong, Qian He, Xiaomei Shan, Keyang Chen, Fen Huang
Pentachlorophenol (PCP) was used in large quantities, and mainly for killing the intermediate host snails of schistosome in China, thereby resulting in ubiquitous PCP residue in the environment. However, studies considering the carcinogenicity of PCP for humans mainly focused on occupational workers, and the actual carcinogenicity of PCP for general population is uncertain. To investigate the association between cancer risks and PCP exposure in a community population, an ecological study was conducted in three contaminated areas along the Yangtze River...
January 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28092161/estimation-of-ellagic-acid-and-or-repaglinide-effects-on-insulin-signaling-oxidative-stress-and-inflammatory-mediators-of-liver-pancreas-adipose-tissue-and-brain-in-insulin-resistant-type-2-diabetic-rats
#6
Mohamed M Amin, Mahmoud S Arbid
Even though ellagic acid has previously been valued in many models of cancer, so far its full mechanistic effect as a natural antiapoptotic agent in the prevention of type 2 diabetes complications has not been completely elucidated, which was the goal of this study. We fed albino rats a high-fat fructose diet (HFFD) for 2 months to induce insulin resistance/type 2 diabetes and then treated the rats with ellagic acid (10 mg/kg body weight, orally) and/or repaglinide (0.5 mg/kg body weight, orally) for 2 weeks...
October 21, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28088230/relationship-between-the-uptake-of-18-f-borono-l-phenylalanine-and-l-methyl-11-c-methionine-in-head-and-neck-tumors-and-normal-organs
#7
Yoshiaki Watanabe, Hiroaki Kurihara, Jun Itami, Ryohei Sasaki, Yasuaki Arai, Kazuro Sugimura
BACKGROUND AND PURPOSE: The purpose of this study was to determine the distribution of 4-borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) and L-[methyl-(11)C] methionine ((11)C-Met) in normal organs and tumors and to evaluate the usefulness of (11)C-Met/PET in screening potential candidates for boron neutron capture therapy (BNCT). MATERIAL METHODS: Seven patients who had at least one histologically confirmed head and neck tumor were included in this study. They underwent both whole-body (18)F-BPA-PET/CT and (11)C-Met-PET/CT within a span of 6 months...
January 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28080913/liver-ultrasonography-in-dolphins-use-of-ultrasonography-to-establish-a-technique-for-hepatobiliary-imaging-and-to-evaluate-metabolic-disease-associated-liver-changes-in-bottlenose-dolphins-tursiops-truncatus
#8
Kelsey E Seitz, Cynthia R Smith, Stanley L Marks, Stephanie K Venn-Watson, Marina Ivančić
The objective of this study was to establish a comprehensive technique for ultrasound examination of the dolphin hepatobiliary system and apply this technique to 30 dolphins to determine what, if any, sonographic changes are associated with blood-based indicators of metabolic syndrome (insulin greater than 14 μIU/ml or glucose greater than 112 mg/dl) and iron overload (transferrin saturation greater than 65%). A prospective study of individuals in a cross-sectional population with and without elevated postprandial insulin levels was performed...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28078856/decreased-immunoreactivity-of-visfatin-in-the-pancreas-and-liver-of-rats-with-renovascular-hypertension
#9
Ż Piotrowska, I Janiuk, A Lewandowska, I Kasacka
Hypertension is one of the major endocrine and metabolic disorders, in which visfatin plays a significant role. The objective of this study was to evaluate the immunoreactivity of visfatin in pancreas and liver of “two kidney, one clip” (2K1C) renovascular hypertension model in rats. The studies were carried out on the pancreas and liver of rats. After a 6-week period of the renal artery clipping procedure, 2K1C rats developed a stable hypertension. Paraffin sections were stained with hematoxylin and eosin (for general histological examination) and processed for immunolocalization of visfatin...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28078110/radioembolization-with-90-y-glass-microspheres-for-the-treatment-of-unresectable-metastatic-liver-disease-from-chemotherapy-refractory-gastrointestinal-cancers-final-report-of-a-prospective-pilot-study
#10
Nicholas Fidelman, Robert K Kerlan, Randall A Hawkins, Miguel Pampaloni, Andrew G Taylor, Maureen P Kohi, K Pallav Kolli, Chloe E Atreya, Emily K Bergsland, R Kate Kelley, Andrew H Ko, W Michael Korn, Katherine Van Loon, Ryan M McWhirter, Jennifer Luan, Curt Johanson, Alan P Venook
BACKGROUND: This prospective pilot single-institution study was undertaken to document the feasibility, safety, and efficacy of radioembolization of liver-dominant metastatic gastrointestinal cancer using (90)Y glass microspheres. METHODS: Between June 2010 and October 2013, 42 adult patients (26 men, 16 women; median age 60 years) with metastatic chemotherapy-refractory unresectable colorectal (n=21), neuroendocrine (n=11), intrahepatic bile duct (n=7), pancreas (n=2), and esophageal (n=1) carcinomas underwent 60 lobar or segmental administrations of (90)Y glass microspheres...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28077572/impact-of-high-fat-diet-on-tissue-acyl-coa-and-histone-acetylation-levels
#11
Alessandro Carrer, Joshua L D Parris, Sophie Trefely, Ryan A Henry, David C Montgomery, AnnMarie Torres, John M Viola, Yin-Ming Kuo, Ian A Blair, Jordan L Meier, Andrew J Andrews, Nathaniel W Snyder, Kathryn E Wellen
Cellular metabolism dynamically regulates the epigenome via availability of the metabolite substrates of chromatin-modifying enzymes. The impact of diet on the metabolism-epigenome axis is poorly understood, but could alter gene expression and influence metabolic health. ATP-citrate lyase (ACLY) produces acetyl-CoA in the nucleus and cytosol and regulates histone acetylation levels in many cell types. Consumption of a high fat diet (HFD) results in suppression of ACLY levels in tissues such as adipose and liver, but the impact of diet on acetyl-CoA and histone acetylation in these tissues remains unknown...
January 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28077438/fibroblast-drug-scavenging-increases-intratumoural-gemcitabine-accumulation-in-murine-pancreas-cancer
#12
E Hessmann, M S Patzak, L Klein, N Chen, V Kari, I Ramu, T E Bapiro, K K Frese, A Gopinathan, F M Richards, D I Jodrell, C Verbeke, X Li, R Heuchel, J M Löhr, S A Johnsen, T M Gress, V Ellenrieder, A Neesse
OBJECTIVE: Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier for gemcitabine delivery. DESIGN: Gemcitabine metabolites were analysed in LSL-Kras(G12D/+); LSL-Trp53(R172H/+); Pdx-1-Cre (KPC) murine tumours and matched liver metastases, primary tumour cell lines, cancer-associated fibroblasts (CAFs) and pancreatic stellate cells (PSCs) by liquid chromatography-mass spectrometry/mass spectrometry...
January 10, 2017: Gut
https://www.readbyqxmd.com/read/28074019/point-organ-radiation-dose-in-abdominal-ct-effect-of-patient-off-centering-in-an-experimental-human-cadaver-study
#13
Ranish Deedar Ali Khawaja, Sarabjeet Singh, Atul Padole, Alexi Otrakji, Diego Lira, Da Zhang, Bob Liu, Andrew Primak, George Xu, Mannudeep K Kalra
To determine the effect of patient off-centering on point organ radiation dose measurements in a human cadaver scanned with routine abdominal CT protocol. A human cadaver (88 years, body-mass-index 20 kg/m(2)) was scanned with routine abdominal CT protocol on 128-slice dual source MDCT (Definition Flash, Siemens). A total of 18 scans were performed using two scan protocols (a) 120 kV-200 mAs fixed-mA (CTDIvol 14 mGy) (b) 120 kV-125 ref mAs (7 mGy) with automatic exposure control (AEC, CareDose 4D) at three different positions (a) gantry isocenter, (b) upward off-centering and (c) downward off-centering...
January 10, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28069811/tgf-%C3%AE-1-smad3-pathway-targets-pp2a-ampk-foxo1-to-regulate-hepatic-gluconeogenesis
#14
Hariom Yadav, Samir Devalaraja, Stephanie Chung, Sushil G Rane
Maintenance of glucose homeostasis is essential for normal physiology. Deviation from normal glucose levels, in either direction, increases susceptibility to serious medical complications such as hypoglycemia or diabetes. Maintenance of glucose homeostasis is achieved via functional interactions amongst various organs, liver, skeletal muscle, adipose tissue, brain and the endocrine pancreas. The liver is the primary site for endogenous glucose production, especially during states of prolonged fasting. However, enhanced gluconeogenesis is also a signature feature of type 2 diabetes (T2D)...
January 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28069746/non-alcoholic-fatty-pancreas-disease
#15
REVIEW
Tamara Alempijevic, Sanja Dragasevic, Simon Zec, Dragan Popovic, Tomica Milosavljevic
Obesity is a growing problem worldwide and disorders associated with excess body fat including the metabolic syndrome, type 2 diabetes mellitus (T2DM), cardiovascular disease and malignant neoplasms are becoming a major cause of morbidity and mortality. Over the past decade, a vast amount of research has furthered our understanding of non-alcoholic fatty liver disease; however, only recently pancreatic fat infiltration is coming to the forefront of investigation. Termed non-alcoholic fatty pancreas disease (NAFPD), it is becoming evident that it has important associations with other diseases of obesity...
January 9, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28068959/pancreatic-neuroendocrine-tumor-with-metastasis-to-the-spleen-a-case-report
#16
Yasunaru Sakuma, Yoshikazu Yasuda, Naohiro Sata, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyuki Fukushima, Atsushi Miki, Misato Maeno, Alan Kawarai Lefor
BACKGROUND: Long-term term survival in patients with pancreatic neuroendocrine tumors has been reported, even in patients with metastatic disease. Metastases to the spleen are extremely rare, but have been reported from a number of primary malignancies, such as breast cancer, lung cancer, melanoma and ovarian cancer. This is the first report of a splenic metastasis from a primary pancreatic neuroendocrine tumor. CASE PRESENTATION: The patient presented as a 53 years old white male with anemia and fatigue...
January 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28068731/-geriatric-ultrasound
#17
Eckhart Froehlich, Jan Pauluschke-Froehlich, Ines Debove, Werner Vey, Christoph Klinger, Christoph F Dietrich
In geriatric patients, ultrasound is the appropriate diagnostic technique to detect and to follow-up underlying and accompanying diseases of the heart, lung, liver, kidneys, pancreas, gastrointestinal tract and of arterial and venous vessels. Based on a systematic survey of the published literature, this review describes the value of ultrasound in geriatric patients focussing on point of care.
January 9, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28067312/adeno-associated-virus-serotype-rh-10-displays-strong-muscle-tropism-following-intraperitoneal-delivery
#18
Jianzhong Ai, Jia Li, Dominic J Gessler, Qin Su, Qiang Wei, Hong Li, Guangping Gao
Recombinant adeno-associated virus (rAAV) is an attractive tool for basic science and translational medicine including gene therapy, due to the versatility in its cell and organ transduction. Previous work indicates that rAAV transduction patterns are highly dependent on route of administration. Based on this relationship, we hypothesized that intraperitoneal (IP) administration of rAAV produces unique patterns of tissue tropism. To test this hypothesis, we investigated the transduction efficiency of 12 rAAV serotypes carrying an enhanced green fluorescent protein (EGFP) reporter gene in a panel of 12 organs after IP injection...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28063144/undifferentiated-carcinoma-of-the-ampulla-of-vater
#19
Misuzu Yamada, Daisuke Furukawa, Naoki Yazawa, Hideki Izumi, Yoshihito Masuoka, Taro Mashiko, Yoshiaki Kawaguchi, Masami Ogawa, Yohei Kawashima, Tetsuya Mine, Kenichi Hirabayashi, Toshio Nakagohri
Undifferentiated carcinoma of the ampulla of Vater is a rare disease with unclear and clinical characteristics and prognosis. Here, we report the case of a 61-year-old man with undifferentiated carcinoma of the ampulla of Vater. He presented to our hospital with an increase in hepatobiliary system enzymes that was detected during a health check-up. Imaging and endoscopy demonstrated a tumor with ulcer in the ampulla of Vater, which was diagnosed as a carcinoma by biopsy. No distant metastasis was observed. Subtotal stomach-preserving pancreaticoduodenectomy was performed...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28061406/potent-antihyperglycemic-and-hypoglycemic-effect-of-tamarix-articulata-vahl-in-normal-and-streptozotocin-induced-diabetic-rats
#20
Morad Hebi, Omra Farid, Mohammed Ajebli, Mohamed Eddouks
The purpose of this study was to investigate the effect of a single dose and daily oral administration for seven days of the aerial part aqueous extract (A.P.A.E) of Tamarix articulata Vahl. (T. articulata) (5mg/kg) on blood glucose levels in both normal and streptozotocin-induced diabetic rats (STZ). Single oral administration of T. articulata A.P.A.E reduced blood glucose levels 6h after administration in normal rats (p<0.0001) and STZ diabetic rats (p<0.001). Furthermore, blood glucose levels were decreased in both normal (p<0...
January 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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