Dennis Schaefer-Babajew, Zijun Wang, Frauke Muecksch, Alice Cho, Maximilian Loewe, Melissa Cipolla, Raphael Raspe, Brianna Johnson, Marie Canis, Justin DaSilva, Victor Ramos, Martina Turroja, Katrina G Millard, Fabian Schmidt, Leander Witte, Juan Dizon, Irina Shimelovich, Kai-Hui Yao, Thiago Y Oliveira, Anna Gazumyan, Christian Gaebler, Paul D Bieniasz, Theodora Hatziioannou, Marina Caskey, Michel C Nussenzweig
Feedback inhibition of humoral immunity by antibodies was first documented in 19091 . Subsequent work showed that, depending on the context, antibodies can enhance or inhibit immune responses2,3 . However, little is known about how pre-existing antibodies influence the development of memory B cells. Here we examined the memory B cell response in individuals who received two high-affinity anti-SARS-CoV-2 monoclonal antibodies, and subsequently two doses of an mRNA vaccine4-8 . We found that monoclonal antibody recipients produced antigen binding and neutralizing titers that were only fractionally lower than controls...
December 6, 2022: Nature