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https://www.readbyqxmd.com/read/28926616/co-ordinated-activation-of-classical-and-novel-pkc-isoforms-is-required-for-pma-induced-mtorc1-activation
#1
Mengling Liu, Christopher J Clarke, Mohamed F Salama, Yeon Ja Choi, Lina M Obeid, Yusuf A Hannun
Protein kinase C (PKC) has been shown to activate the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, a central hub in the regulation of cell metabolism, growth and proliferation. However, the mechanisms by which PKCs activate mTORC1 are still ambiguous. Our previous study revealed that activation of classical PKCs (cPKC) results in the perinuclear accumulation of cPKC and phospholipase D2 (PLD2) in recycling endosomes in a PLD2-dependent manner. Here, we report that mTORC1 activation by phorbol 12,13-myristate acetate (PMA) requires both classic, cPKC, and novel PKC (nPKC) isoforms, specifically PKCη, acting through distinct pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28903690/how-moral-perceptions-influence-intergroup-tolerance-evidence-from-lebanon-morocco-and-the-united-states
#2
Nadine Obeid, Nichole Argo, Jeremy Ginges
Intergroup boundaries are often associated with differences in moral codes. How does the perception of similarity and dissimilarity in moral worldviews influence tolerant relationships between members of different groups? We theorized that the relationship between perceived moral similarity and intergroup tolerance is domain specific. Specifically, because people treat autonomy values (e.g., caring for others, being fair) as denoting universal rights and obligations, but binding values (e.g., purity) as denoting rights and obligations that apply preferentially for their own group, perceived similarity on autonomy values should be more relevant than perceived similarity on binding values to intergroup tolerance...
March 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28885128/sagittal-alignment-and-complications-following-lumbar-3-column-osteotomy-does-the-level-of-resection-matter
#3
Emmanuelle Ferrero, Barthelemy Liabaud, Jensen K Henry, Christopher P Ames, Khaled Kebaish, Gregory M Mundis, Richard Hostin, Munish C Gupta, Oheneba Boachie-Adjei, Justin S Smith, Robert A Hart, Ibrahim Obeid, Bassel G Diebo, Frank J Schwab, Virginie Lafage
OBJECTIVE Three-column osteotomy (3CO) is a demanding technique that is performed to correct sagittal spinal malalignment. However, the impact of the 3CO level on pelvic or truncal sagittal correction remains unclear. In this study, the authors assessed the impact of 3CO level and postoperative apex of lumbar lordosis on sagittal alignment correction, complications, and revisions. METHODS In this retrospective study of a multicenter spinal deformity database, radiographic data were analyzed at baseline and at 1- and 2-year follow-up to quantify spinopelvic alignment, apex of lordosis, and resection angle...
September 8, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28871507/delayed-post-operative-tension-pneumocephalus-and-pneumorrhachis
#4
D C Kieser, D T Cawley, C Tavolaro, T Cloche, I Obeid, V Pointillart, J M Vital, O Gille
INTRODUCTION: The incidence of pneumocephalus and pneumorrhachis after spinal surgery is unknown, with a paucity of literature on this complication. MATERIALS AND METHODS: We present the first published case of delayed onset tension pneumocephalus and pneumorrhachis associated with spinal surgery. RESULTS: This complication occurred from a cerebro-spinal fluid (CSF) leak after posterior instrumentation removal and was successfully treated with emergent wound debridement and the formation of a CSF fistula...
September 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28867024/impact-of-stroke-volume-assessment-by-integrating-multi-detector-computed-tomography-and-doppler-data-on-the-classification-of-aortic-stenosis
#5
Barbara E Stähli, Thomas Stadler, Erik W Holy, Thi Dan Linh Nguyen-Kim, Lisa Hoffelner, Ladina Erhart, Slayman Obeid, Markus Niemann, Rolf Jenni, Sandra Hamada, Robert Manka, Thomas F Lüscher, Francesco Maisano, Fabian Nietlispach, Thomas Frauenfelder, Felix C Tanner
BACKGROUND: The prevalence of low flow low gradient (LFLG) severe aortic stenosis (AS) may be overrated due to underestimation of stroke volume in two-dimensional (2D) echocardiography. The implications of 3D imaging on stroke volume calculation for AS classification have not been elucidated. Integrating multi-detector computed tomography (MDCT) and Doppler data may improve diagnostic accuracy in patients with LFLG AS. METHODS: A total of 186 patients with severe AS evaluated for transcatheter aortic valve replacement were classified according to indexed stroke volume (SVI, cut-off 35mL/m(2)) and mean transaortic pressure gradient (cut-off 40mmHg)...
November 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28866740/factor-analysis-of-the-srs-22-outcome-assessment-instrument-in-patients-with-adult-spinal-deformity
#6
A F Mannion, A Elfering, J Bago, F Pellise, A Vila-Casademunt, S Richner-Wunderlin, M Domingo-Sàbat, I Obeid, E Acaroglu, A Alanay, F S Pérez-Grueso, C R Baldus, L Y Carreon, K H Bridwell, S D Glassman, F Kleinstück
PURPOSE: Designed for patients with adolescent idiopathic scoliosis, the SRS-22 is now widely used as an outcome instrument in patients with adult spinal deformity (ASD). No studies have confirmed the four-factor structure (pain, function, self-image, mental health) of the SRS-22 in ASD and under different contexts. Factorial invariance of an instrument over time and in different languages is essential to allow for precise interpretations of treatment success and comparisons across studies...
September 2, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28864659/a-novel-role-for-ceramide-synthase-6-in-mouse-and-human-alcoholic-steatosis
#7
Bianca Williams, Jason Correnti, Amanke Oranu, Annie Lin, Victoria Scott, Maxine Annoh, James Beck, Emma Furth, Victoria Mitchell, Can E Senkal, Lina Obeid, Rotonya M Carr
Perilipin 2 (PLIN2) is a lipid-droplet protein that is up-regulated in alcoholic steatosis and associated with hepatic accumulation of ceramides, bioactive lipids implicated in alcoholic liver disease pathogenesis. The specific role of ceramide synthetic enzymes in the regulation of PLIN2 and promotion of hepatocellular lipid accumulation is not well understood. We examined the effects of pharmacologic ceramide synthesis inhibition on hepatic PLIN2 expression, steatosis, and glucose and lipid homeostasis in mice with alcoholic steatosis and in ethanol-incubated human hepatoma VL17A cells...
September 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28859025/seizures-induced-by-exiting-water-a-unique-form-of-reflex-epilepsy
#8
Brian Appavu, Jordana Fox, Robert Little, John F Kerrigan, Makram Obeid
INTRODUCTION: Reflex epilepsies represent a form of epilepsy in which unique modes of seizure precipitation are characterized by endogenous or exogenous stimuli. Hot water epilepsy represents a subtype of reflex epilepsy in which seizure precipitation arises from the act of immersing the head with hot water. Bathing epilepsy represents another subtype of reflex epilepsy in which seizure precipitation arises from the immersion with water at lukewarm temperatures. CASE SERIES: We report on 2 boys with a unique form of bathing epilepsy characterized by the act of exiting out of water...
September 2017: Neurologist
https://www.readbyqxmd.com/read/28856486/the-automated-assessment-of-postural-stability-balance-detection-algorithm
#9
Alessandro Napoli, Stephen M Glass, Carole Tucker, Iyad Obeid
Impaired balance is a common indicator of mild traumatic brain injury, concussion and musculoskeletal injury. Given the clinical relevance of such injuries, especially in military settings, it is paramount to develop more accurate and reliable on-field evaluation tools. This work presents the design and implementation of the automated assessment of postural stability (AAPS) system, for on-field evaluations following concussion. The AAPS is a computer system, based on inexpensive off-the-shelf components and custom software, that aims to automatically and reliably evaluate balance deficits, by replicating a known on-field clinical test, namely, the Balance Error Scoring System (BESS)...
August 30, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28846880/analyzing-driver-pedestrian-interaction-in-a-mixed-street-environment-using-a-driving-simulator
#10
Hassan Obeid, Hoseb Abkarian, Maya Abou-Zeid, Isam Kaysi
This paper presents the design, analysis and results of a driving simulator experiment conducted to study the interaction between drivers and pedestrians in a mixed-street environment. Ninety-six students of the American University of Beirut (AUB) participated in the experiment that took place in the Transportation and Infrastructure Laboratory of AUB. The study looked at the driver-pedestrian interaction from the driver's perspective, by quantifying the effects of different scenario variables on the driving behavior of the participants...
August 25, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28840343/sleeve-gastrectomy-the-first-3%C3%A2-years-evaluation-of-emergency-department-visits-readmissions-and-reoperations-for-14-080-patients-in-new-york-state
#11
Maria S Altieri, Jie Yang, Donald Groves, Nabeel Obeid, Jihye Park, Mark Talamini, Aurora Pryor
INTRODUCTION: The purpose of our study was to evaluate the indications for and incidence of both emergency department (ED) visits and hospital readmissions within the first postoperative year. We also sought to identify the rate of reoperation within the first 3 years following a SG operation in New York State (NYS). METHODS: The SPARCS database was examined for all SGs performed between 2011 and 2013. Using a unique identifier, patients were followed for at least 1 year...
August 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28837713/the-hereditary-paraganglioma-pheochromocytoma-syndrome-no-time-to-waste
#12
Michael J Hall, Andrea D Forman, Elias Obeid
No abstract text is available yet for this article.
August 24, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28830409/word2vec-inversion-and-traditional-text-classifiers-for-phenotyping-lupus
#13
Clayton A Turner, Alexander D Jacobs, Cassios K Marques, James C Oates, Diane L Kamen, Paul E Anderson, Jihad S Obeid
BACKGROUND: Identifying patients with certain clinical criteria based on manual chart review of doctors' notes is a daunting task given the massive amounts of text notes in the electronic health records (EHR). This task can be automated using text classifiers based on Natural Language Processing (NLP) techniques along with pattern recognition machine learning (ML) algorithms. The aim of this research is to evaluate the performance of traditional classifiers for identifying patients with Systemic Lupus Erythematosus (SLE) in comparison with a newer Bayesian word vector method...
August 22, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28828581/optimizing-tumor-immune-response-through-combination-of-radiation-and-immunotherapy
#14
REVIEW
Alissar El Chediak, Ali Shamseddine, Larry Bodgi, Jean-Pierre Obeid, Fady Geara, Youssef H Zeidan
Radiation therapy and immunotherapy are two highly evolving modalities for the treatment of solid tumors. Immunotherapeutic drugs can either stimulate the immune system via immunogenic pathways or target co-inhibitory checkpoints. An augmented tumor cell recognition by host immune cells can be achieved post-irradiation, as irradiated tissues can release chemical signals which are sensed by the immune system resulting in its activation. Different strategies combining both treatment modalities were tested in order to achieve a better therapeutic response and longer tumor control...
August 21, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28825569/-laparoscopic-atypical-gastrectomy-in-the-treatment-of-gastric-gist-short-term-and-medium-term-outcomes
#15
Santiago Reimondez, Federico Moser, Pablo S Maldonado, Álvaro Alcaraz, Alejandro M Rossini, Lucio R Obeide
Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract. Recently, many studies have addressed the laparoscopic management of these tumors. The aim of this study was to evaluate the safety and efficacy of laparoscopic atypical gastrectomy in the resolution of these neoplasms. In the period between January 2009 and December 2015, 24 patients with suspected gastric GIST less than 5 cm in size underwent surgery under this approach. Abscense of peritoneal and liver metastases and immunohistochemistry expression of CD117 antigen were considered as inclusion criteria...
2017: Medicina
https://www.readbyqxmd.com/read/28812924/susceptibility-testing-and-reporting-of-new-antibiotics-with-a-focus-on-tedizolid-an-international-working-group-report
#16
Mark H Wilcox, Natalia Dmitrieva, Ana Cristina Gales, Irina Petukhova, Suleiman Al-Obeid, Flavia Rossi, Joseph M Blondeau
Inappropriate use and overuse of antibiotics are among the most important factors in resistance development, and effective antibiotic stewardship measures are needed to optimize outcomes. Selection of appropriate antimicrobials relies on accurate and timely antimicrobial susceptibility testing. However, the availability of clinical breakpoints and in vitro susceptibility testing often lags behind regulatory approval by several years for new antimicrobials. A Working Group of clinical/medical microbiologists from Brazil, Canada, Mexico, Saudi Arabia, Russia and the UK recently examined issues surrounding antimicrobial susceptibility testing for novel antibiotics...
August 16, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28810355/effects-of-a-randomized-trial-comparing-standard-and-enhanced-counseling-for-men-at-high-risk-of-prostate-cancer-as-a-function-of-race-and-monitoring-style
#17
Pagona Roussi, Suzanne M Miller, Veda N Giri, Elias Obeid, Kuang-Yi Wen, Erin K Tagai, John Scarpato, Laura Gross, Gem Roy
Despite conflicting guidelines, a significant subset of high-risk men decide to undergo routine prostate cancer screening. Yet, there is a scarcity of available programs, and no studies evaluating interventions to support men in dealing with the psychosocial impact of screening. In this study, one of the first to explore the responses of high-risk men enrolling in a Prostate Cancer Risk Assessment Program ( N = 128), patients underwent a prostate cancer risk counseling visit immediately followed by either a cognitive-affective preparation session designed to help them process the information they received or a general health education session...
October 1, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810182/selenium-increases-hepatic-dna-methylation-and-modulates-one-carbon-metabolism-in-the-liver-of-mice
#18
Bodo Speckmann, Sarah Schulz, Franziska Hiller, Deike Hesse, Fabian Schumacher, Burkhard Kleuser, Jürgen Geisel, Rima Obeid, Tilman Grune, Anna P Kipp
The average intake of the essential trace element selenium (Se) is below the recommendation in most European countries, possibly causing sub-optimal expression of selenoproteins. It is still unclear how a suboptimal Se status may affect health. To mimic this situation, mice were fed one of three physiologically relevant amounts of Se. We focused on the liver, the organ most sensitive to changes in the Se supply indicated by hepatic glutathione peroxidase activity. In addition, liver is the main organ for synthesis of methyl groups and glutathione via one-carbon metabolism...
July 9, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28797672/single-stage-conversion-from-adjustable-gastric-banding-to-sleeve-gastrectomy-or-roux-en-y-gastric-bypass-an-analysis-of-4875-patients
#19
Konstantinos Spaniolas, Andrew T Bates, Salvatore Docimo, Nabeel R Obeid, Mark A Talamini, Aurora D Pryor
BACKGROUND: The previous popularity of adjustable gastric banding (AGB), along with inconsistent long-term results, has resulted in the need for conversion to other procedures. The perioperative safety of laparoscopic sleeve gastrectomy (SG) and gastric bypass (RYGB) as single-stage conversion procedures is unclear. OBJECTIVES: To compare the early safety of SG and RYGB when performed as single-stage conversion procedures at the time of AGB removal. SETTING: Nationwide analysis of accredited centers...
July 15, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28795268/management-of-a-high-thoracic-chance-fracture
#20
Anouar Bourghli, Ibrahim Obeid, Louis Boissiere, Jean-Marc Vital, Zafer Tabboush, Mohammed Al Sarawan
PURPOSE: Chance fracture of the high thoracic spine is rare, and its impact on the adjacent cervical spine can be important. METHODS: We present the case of a 16-year-old male, who fell down from a 2 m height, in an unknown context as he has a mental retardation, and no witness saw the accident. Initial CT scan revealed a comminuted depressed fracture of the right parietal bone, associated with a chance fracture at the level of T3 with a kyphosis and bilateral lung contusion...
August 9, 2017: European Spine Journal
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