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https://www.readbyqxmd.com/read/28089767/the-correlation-between-a-short-term-conventional-electroencephalography-in-the-first-day-of-life-and-brain-magnetic-resonance-imaging-in-newborns-undergoing-hypothermia-for-hypoxic-ischemic-encephalopathy
#1
Rawad Obeid, Yoshimi Sogawa, Satyanarayana Gedela, Monica Naik, Vince Lee, Richard Telesco, Jessica Wisnowski, Christine Magill, Michael J Painter, Ashok Panigrahy
OBJECTIVE: Electroencephalograph recorded in the first day of life in newborns treated with hypothermia for hypoxic-ischemic encephalopathy could be utilized as a predictive tool for the severity of brain injury on magnetic resonance imaging and mortality. STUDY DESIGN: This work was a retrospective study of newborns who were admitted for therapeutic hypothermia due to hypoxic-ischemic encephalopathy. All enrolled infants underwent encephalography within the first 24 hours of life and underwent brain magnetic resonance imaging after rewarming...
November 3, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/28087395/lumbar-spinal-muscles-and-spinal-canal-study-by-mri-three-dimensional-reconstruction-in-adult-lumbar-spinal-stenosis
#2
Louis Boissière, Bertrand Moal, Olivier Gille, Elise De-Roquefeuil, Muriel Durieux, Ibrahim Obeid, Vincent Dousset, Jean-Marc Vital, Wafa Skalli
BACKGROUND: Lumbar spinal stenosis is degenerative disc disease most common manifestation. If stenosis degree seems poorly related to symptom severity, lumbar muscles role is recognized. Many studies report imaging methods, to analyze muscle volumes and fat infiltration (FI), but remain limited due to the difficulty to represent entire muscle volume variability. Recently a 3D muscle reconstruction protocol (using the deformation of a parametric specific object method (DPSO) and three point Dixon images) was reported...
January 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28077467/gut-microbiota-dependent-trimethylamine-n-oxide-in-acute-coronary-syndromes-a-prognostic-marker-for-incident-cardiovascular-events-beyond-traditional-risk-factors
#3
Xinmin S Li, Slayman Obeid, Roland Klingenberg, Baris Gencer, François Mach, Lorenz Räber, Stephan Windecker, Nicolas Rodondi, David Nanchen, Olivier Muller, Melroy X Miranda, Christian M Matter, Yuping Wu, Lin Li, Zeneng Wang, Hassan S Alamri, Valentin Gogonea, Yoon-Mi Chung, W H Wilson Tang, Stanley L Hazen, Thomas F Lüscher
AIMS: Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism of dietary trimethylamine (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary and secondary prevention subjects. However, the prognostic value of TMAO in the setting of acute coronary syndromes (ACS) remains unknown. METHODS AND RESULTS: We investigated the relationship of TMAO levels with incident cardiovascular risks among sequential patients presenting with ACS in two independent cohorts...
January 11, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28054964/effect-of-two-different-multimicronutrient-supplements-on-vitamin-d-status-in-women-of-childbearing-age-a-randomized-trial
#4
Stefan Pilz, Andreas Hahn, Christiane Schön, Manfred Wilhelm, Rima Obeid
The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25(OH)D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101)...
January 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28052884/vitamin-b-12-fortified-toothpaste-improves-vitamin-status-in-vegans-a-12-wk-randomized-placebo-controlled-study
#5
Anne-Kathrin Siebert, Rima Obeid, Stine Weder, Hussain M Awwad, Andreas Sputtek, Juergen Geisel, Markus Keller
BACKGROUND: The oral application of vitamin B-12 may prevent its deficiency if the vitamin is absorbed via the mucosal barrier. OBJECTIVES: We studied the effect of the use of a vitamin B-12-fortified toothpaste on vitamin-status markers in vegans and assessed the efficiency of markers in the identification of vitamin-augmentation status. DESIGN: In this 12-wk, double-blinded, randomized, placebo-controlled study, 76 vegans received either a placebo (n = 34) or vitamin B-12 (n = 42) toothpaste...
January 4, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28042530/enzyme-prodrug-systems-for-cancer-gene-therapy
#6
Obeid M Malekshah, Xuguang Chen, Alireza Nomani, Siddik Sarkar, Arash Hatefi
The use of enzyme/prodrug system has gained attention because it could help improve the efficacy and safety of conventional cancer chemotherapies. In this approach, cancer cells are first transfected with a gene that can express an enzyme with ability to convert a non-toxic prodrug into its active cytotoxic form. As a result, the activated prodrug could kill the transfected cancer cells. Despite the significant progress of different suicide gene therapy protocols in preclinical studies and early clinical trials, none has reached the clinic due to several shortcomings...
December 2016: Current Pharmacology Reports
https://www.readbyqxmd.com/read/28028421/the-use-of-different-irrigation-techniques-to-decrease-bacterial-loads-in-healthy-and-diabetic-patients-with-asymptomatic-apical-periodontitis
#7
Mai Ghoneim, Shehab ElDin Saber, Tarek El-Badry, Maram Obeid, Nehal Hassib
BACKGROUND: Diabetes mellitus is a multisystem disease which weakens the human's immunity. Subsequently, it worsens the sequelae of apical periodontitis by raising a fierce bacterial trait due to the impaired host response. AIM: This study aimed to estimate bacterial reduction after using different irrigation techniques in systemically healthy and diabetic patients with asymptomatic apical periodontitis. MATERIAL AND METHODS: Enterococcus faecalis, Peptostreptococcus micros, and Fusobacterium necleatum bacteria were chosen, as they are the most common and prevailing strains found in periodontitis...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27999753/pd-l1-pd-l2-and-pd-1-expression-in-metastatic-melanoma-correlation-with-tumor-infiltrating-immune-cells-and-clinical-outcome
#8
Joseph M Obeid, Gulsun Erdag, Mark E Smolkin, Donna H Deacon, James W Patterson, Leiping Chen, Timothy N Bullock, Craig L Slingluff
Therapeutic blockade of PD-1/PD-L1 can have dramatic therapeutic benefit in some patients; however, the prognostic associations of PD-1 and its ligands, in the absence of therapeutic blockade have not been definitively addressed. In particular, associations of PD-L2 with immune infiltrates and with outcome have yet to be explored. We hypothesized that surface expression of both PD-L1 and PD-L2 by melanoma cells would be associated with immune cell infiltration and with overall patient survival, independent of checkpoint blockade therapy...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27990147/molecular-characterization-of-rice-oslcb2a1-gene-and-functional-analysis-of-its-role-in-insect-resistance
#9
Mahfuj A Begum, Xiao-Xiao Shi, Ye Tan, Wen-Wu Zhou, Yusuf Hannun, Lina Obeid, Cungui Mao, Zeng-Rong Zhu
In plants, sphingolipids, such as long-chain bases (LCBs), act as bioactive molecules in stress responses. Until now, it is still not clear if these lipids are involved in biotic stress responses to herbivore. Herein we report that a rice LCB gene, OsLCB2a1 encoding a subunit of serine palmitoyltransferase (SPT), a key enzyme responsible for the de novo biosynthesis of sphingolipids, plays a critical role in plant defense response to the brown planthopper (BPH) attack and that its up-regulation protects plants from herbivore infestation...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27941661/phosphorus-supplementation-recovers-the-blunted-diet-induced-thermogenesis-of-overweight-and-obese-adults-a-pilot-study
#10
Maya S Bassil, Omar A Obeid
Diet-induced thermogenesis (DIT) is believed to be largely related to ATP production, which is dependent on phosphorus (P) availability. We aimed to test the effect of P addition on DIT of lean and overweight/obese healthy subjects. DIT was measured with or without P in 10 lean and 13 overweight/obese adults in a double-blind randomized cross-over pilot study with one week washout period. After 10 h overnight fast, resting metabolic rate, respiratory quotient, and substrate utilization were measured at fasting and every 30 min for 3 h after subjects drank a standardized glucose solution, with P (500 mg) or placebo pills...
December 9, 2016: Nutrients
https://www.readbyqxmd.com/read/27927574/untreated-thoracic-curve-in-adult-idiopathic-scoliosis-what-are-patients-concerns
#11
Javier Pizones, Mar Pérez Martin-Buitrago, Francisco Javier Sánchez Perez-Grueso, Ferran Pellisé, Ahmet Alanay, Ibrahim Obeid, Frank Kleinstück, Emre R Acaroglu
STUDY DESIGN: Retrospective two-cohort comparative analysis of data collected prospectively. OBJECTIVES: To analyze a cohort of patients with untreated thoracic curves of an adult multicenter deformity database [European spine study group (ESSG)], describe patient characteristics and concerns, and establish the rate and motivations for surgical intervention. SUMMARY OF BACKGROUND DATA: Idiopathic thoracic curves have a significant clinical and socioeconomic impact during adolescence...
November 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927523/adult-spinal-deformity-surgeons-are-unable-to-accurately-predict-postoperative-spinal-alignment-using-clinical-judgment-alone
#12
Tamir Ailon, Justin K Scheer, Virginie Lafage, Frank J Schwab, Eric Klineberg, Daniel M Sciubba, Themistocles S Protopsaltis, Lukas Zebala, Richard Hostin, Ibrahim Obeid, Tyler Koski, Michael P Kelly, Shay Bess, Christopher I Shaffrey, Justin S Smith, Christopher P Ames
OBJECT: Adult spinal deformity (ASD) surgery seeks to reduce disability and improve quality of life through restoration of spinal alignment. In particular, correction of sagittal malalignment is correlated with patient outcome. Inadequate correction of sagittal deformity is not infrequent. The present study assessed surgeons' ability to accurately predict postoperative alignment. METHODS: Seventeen cases were presented with preoperative radiographic measurements, and a summary of the operation as performed by the treating physician...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27916380/contemporary-outcomes-of-open-thoracoabdominal-aneurysm-repair-functional-status-is-the-strongest-predictor-of-perioperative-mortality
#13
Tammam Obeid, Caitlin W Hicks, Kanhua Yin, Isibor Arhuidese, Besma Nejim, Arman Kilic, James H Black, Mahmoud Malas
BACKGROUND: Open repair of thoracoabdominal and descending thoracic aneurysm (TAA) carries significant operative morbidity and mortality. Despite evolving operative techniques patient-level risk factors affecting mortality after open TAA repair, including patient functional status, remain to be fully understood. MATERIALS AND METHODS: We identified all open TAA repair cases in the National Surgical Quality Improvement Program database between 2005 and 2013. Multivariable logistic regression was used to evaluate the effect of patients' age, gender, race, body mass index (BMI), comorbid conditions, functional status, ASA class, smoking, rupture, descending thoracic aneurysm versus Crawford types, dissection, and preoperative: transfusion, creatinine levels, on perioperative (30-d) mortality after open TAA repair...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27906189/distinct-outcomes-of-crl-nedd8-pathway-inhibition-reveal-cancer-cell-plasticity
#14
Anastasia V Rulina, Frédérique Mittler, Patricia Obeid, Sophie Gerbaud, Laurent Guyon, Eric Sulpice, Frédérique Kermarrec, Nicole Assard, Monika E Dolega, Xavier Gidrol, Maxim Y Balakirev
Inhibition of protein degradation by blocking Cullin-RING E3 ligases (CRLs) is a new approach in cancer therapy though of unknown risk because CRL inhibition may stabilize both oncoproteins and tumor suppressors. Probing CRLs in prostate cancer cells revealed a remarkable plasticity of cells with TMPRSS2-ERG translocation. CRL suppression by chemical inhibition or knockdown of RING component RBX1 led to reversible G0/G1 cell cycle arrest that prevented cell apoptosis. Conversely, complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL regulator Cand1...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27866974/sphingolipids-in-neutrophil-function-and-inflammatory-responses-mechanisms-and-implications-for-intestinal-immunity-and-inflammation-in-ulcerative-colitis
#15
REVIEW
Mel Pilar Espaillat, Richard R Kew, Lina M Obeid
Bioactive sphingolipids are regulators of immune cell function and play critical roles in inflammatory conditions including ulcerative colitis. As one of the major forms of inflammatory bowel disease, ulcerative colitis pathophysiology is characterized by an aberrant intestinal inflammatory response that persists causing chronic inflammation and tissue injury. Innate immune cells play an integral role in normal intestinal homeostasis but their dysregulation is thought to contribute to the pathogenesis of ulcerative colitis...
November 14, 2016: Advances in Biological Regulation
https://www.readbyqxmd.com/read/27864681/are-sagittal-spinopelvic-radiographic-parameters-significantly-associated-with-quality-of-life-of-adult-spinal-deformity-patients-multivariate-linear-regression-analyses-for-pre-operative-and-short-term-post-operative-health-related-quality-of-life
#16
Mitsuru Takemoto, Louis Boissière, Jean-Marc Vital, Ferran Pellisé, Francisco Javier Sanchez Perez-Grueso, Frank Kleinstück, Emre R Acaroglu, Ahmet Alanay, Ibrahim Obeid
PURPOSE: To evaluate the association in ASD patients between spinopelvic sagittal parameters and health-related quality of life (HRQL), adjusted for demographic and surgical variables. METHODS: We constructed multiple linear regression models to investigate pre-operative (PreOp) and 6-month post-operative (PostOp) HRQL as assessed by the Oswestry Disability Index (ODI), with sagittal parameters as independent variables adjusted for potential confounders, such as age, sex, body mass index, past spine surgery, types of surgical treatment, and complications...
November 18, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27836752/the-effects-of-hydration-media-on-the-characteristics-of-non-ionic-surfactant-vesicles-nisv-prepared-by-microfluidics
#17
Mohammad A Obeid, Ibrahim Khadra, Alexander B Mullen, Rothwelle J Tate, Valerie A Ferro
Non-ionic surfactant vesicles (NISV) are colloidal particles that provide a useful delivery system for drugs and vaccines. One of the methods that is used for NISV preparation is microfluidics in which the lipid components dissolved in organic phase are mixed with an aqueous medium to prepare the particles through self-assembly of the lipids. In this work, we examined the effect of using different types of aqueous media on the characteristics of the NISV prepared by microfluidics. Five aqueous media were tested: phosphate buffered saline, HEPES buffer, Tris buffer, normal saline and distilled water...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27822565/teleconsent-a-novel-approach-to-obtain-informed-consent-for-research
#18
Brandon M Welch, Elizabeth Marshall, Suparna Qanungo, Ayesha Aziz, Marilyn Laken, Leslie Lenert, Jihad Obeid
Lack of recruitment of qualified research participants continues to be a significant bottleneck in clinical trials, often resulting in costly time extensions, underpowered results, and in some cases early termination. Some of the reasons for suboptimal recruitment include laborious consent processes and access to participants at remote locations. While new electronic consents technologies (eConsent) help overcome challenges related to readability and consent management, they do not adequately address challenges related to remote access...
August 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/27815217/global-tilt-and-lumbar-lordosis-index-two-parameters-correlating-with-health-related-quality-of-life-scores-but-how-do-they-truly-impact-disability
#19
L Boissière, M Takemoto, A Bourghli, J M Vital, F Pellisé, A Alanay, C Yilgor, E Acaroglu, F J Perez-Grueso, F Kleinstück, I Obeid
BACKGROUND CONTEXT: Many radiological parameters have been reported to correlate with patient's disability including sagittal vertical axis (SVA), pelvic tilt (PT), and pelvic incidence minus lumbar lordosis (PI-LL). European literature reports other parameters such as lumbar lordosis index (LLI) and the global tilt (GT). If most parameters correlate with health-related quality of life scores (HRQLs), their impact on disability remains unclear. PURPOSE: This study aimed to validate these parameters by investigating their correlation with HRQLs...
November 1, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27807146/scientific-retreats-with-speed-dating-networking-to-stimulate-new-interdisciplinary-translational-research-collaborations-and-team-science
#20
Damayanthi Ranwala, Anthony J Alberg, Kathleen T Brady, Jihad S Obeid, Randal Davis, Perry V Halushka
To stimulate the formation of new interdisciplinary translational research teams and innovative pilot projects, the South Carolina Clinical and Translational Research (SCTR) Institute (South Carolina Clinical and Translational Science Award, CTSA) initiated biannual scientific retreats with 'speed dating' networking sessions. Retreat themes were prioritized based on the following criteria; cross-cutting topic, unmet medical need, generation of novel technologies and methodologies. Each retreat begins with an external keynote speaker followed by a series of brief research presentations by local researchers focused on the retreat theme, articulating potential areas for new collaborations...
November 2, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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