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https://www.readbyqxmd.com/read/28287825/quantification-of-residual-germinal-center-activity-and-hiv-1-dna-and-rna-levels-using-fine-needle-biopsies-of-lymph-nodes-during-antiretroviral-therapy
#1
William J Hey-Nguyen, Yin Xu, Chester F Pearson, Michelle Bailey, Kazuo Suzuki, Robyn Tantau, Solange Obeid, Brad Milner, Andrew Field, Andrew Carr, Mark Bloch, David A Cooper, Anthony D Kelleher, John J Zaunders, Kersten K Koelsch
HIV-1 reservoirs are most often studied in peripheral blood (PB), but not all lymphocytes recirculate, particularly T follicular helper (Tfh) CD4(+) T cells, as well as germinal center (GC) B cells, in lymph nodes (LNs). Ultrasound-guided fine needle biopsies (FNBs) from inguinal LNs and PB samples were obtained from 10 healthy controls (HCs) and 21 HIV-1-infected subjects [11 antiretroviral therapy (ART) naive and 10 on ART]. Tfh cells and GC B cells were enumerated by flow cytometry. HIV-1 DNA and cell-associated (CA) RNA levels in LNs and PB were quantified by real-time polymerase chain reaction...
March 13, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28285031/evolution-and-complications-after-surgery-for-spine-deformation-in-patients-with-parkinson-s-disease
#2
Bouyer Benjamin, Scemama Caroline, P Roussouly, F Laouissat, I Obeid, L Boissière, F-H Parent, S Schuller, J-P Steib, H Pascal-Moussellard, P Guigui, Wolff Stéphane, Riouallon Guillaume
INTRODUCTION: Surgical treatment of spinal deformity is high risk in patients suffering from Parkinson's disease (PD). Several series have already reported a high rate of complications. However, none of these studies included more than 40 patients and none of the risk factors of complications were described. The aim of this study was to describe the rate and risk factors of revision surgery as well as the clinical outcome at the last visit in a large multicenter study of PD patients operated for spinal deformities...
March 8, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28283362/syntax-score-ii-in-patients-with-coronary-artery-disease-undergoing-percutaneous-mitral-repair-with-the-mitraclip
#3
Slayman Obeid, Adrian Attinger-Toller, Maurizio Taramasso, Giovanni Pedrazzini, Gabor Suetsch, Fabienne Landolt, Fatih Karbeyaz, Hector Rodriguez, Daniel Sürder, Tiziano Moccetti, Fabian Nietlispach, Francesco Maisano
BACKGROUND: Percutaneous mitral valve repair (PMVR) using the MitraClip™ system has become a valuable alternative in patients with severe mitral regurgitation (MR) and high surgical risk. We sought to evaluate the prognostic value of the SYNTAX II score (SSII) in patients with concomitant coronary artery disease (CAD) undergoing a Mitraclip procedure. METHODS: In seventy-five consecutive patients who underwent PMVR at the University Heart Center Zürich and the Cardiocentro Ticino, the SSSII was calculated at baseline...
February 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28280688/management-of-anastomosis-leakage-post-ralp-a-simple-trick-for-a-complex-situation
#4
Romain Diamand, Walid Al Hajj Obeid, Anna Accarain, Ksenija Limani, Eric Hawaux, Roland van Velthoven, Alexandre Peltier
A case of 74 years old male patient who underwent RALP with bladder neck reconstruction. Persistent vesicourethral anastomotic leak was seen at cystography. A self-made side fenestrated Foley catheter was used and on the day after, a complete reversal in fluid output between the Foley catheter and the drain was seen.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28273483/ceramide-is-metabolized-to-acylceramide-and-stored-in-lipid-droplets
#5
Can E Senkal, Mohamed F Salama, Ashley J Snider, Janet J Allopenna, Nadia A Rana, Antonius Koller, Yusuf A Hannun, Lina M Obeid
In an approach aimed at defining interacting partners of ceramide synthases (CerSs), we found that fatty acyl-CoA synthase ACSL5 interacts with all CerSs. We demonstrate that ACSL5-generated FA-CoA was utilized with de novo ceramide for the generation of acylceramides, poorly studied ceramide metabolites. Functionally, inhibition of ceramide channeling to acylceramide enhanced accumulation of de novo ceramide and resulted in augmentation of ceramide-mediated apoptosis. Mechanistically, we show that acylceramide generation is catalyzed by diacylglycerol acyltransferase 2 (DGAT2) on lipid droplets...
March 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28269642/automated-assessment-of-postural-stability-system
#6
Alessandro Napoli, Christian R Ward, Stephen M Glass, Carole Tucker, Iyad Obeid
The Balance Error Scoring System (BESS) is one of the most commonly used clinical tests to evaluate static postural stability deficits resulting from traumatic brain events and musculoskeletal injury. This test requires a trained operator to visually assess balance and give the subject a performance score based on the number of balance "errors" they committed. Despite being regularly used in several real-world situations, the BESS test is scored by clinician observation and is therefore (a) potentially susceptible to biased and inaccurate test scores and (b) cannot be administered in the absence of a trained provider...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268436/applications-of-ubms-and-i-vectors-in-eeg-subject-verification
#7
Christian Ward, Joseph Picone, Iyad Obeid
The processing of electroencephalograms (EEGs) is a growing field where mature speech processing techniques are able to rapidly progress development and understanding of the associated neuroscience. I-vectors and Joint Factor Analysis (JFA), along with their foundational universal background models (UBMs) have progressed to a level of understanding that makes them prime for transition to the EEG community. To prove the capability of these techniques they are tested against two contrasting EEG data sets, PhysioNet's EEG Motor Movement/Imagery Dataset and the Temple University Hospital EEG Corpus, to highlight the effectiveness of the techniques with minimal domain knowledge modifications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258220/adiponectin-confers-protection-from-acute-colitis-and-restricts-a-b-cell-immune-response
#8
Stephanie Obeid, Miriam Wankell, Berenice Charrez, Jade Sternberg, Roxane Kreuter, Saeed Esmaili, Mehdi Ramezani-Moghadam, Carol Devine, Scott Read, Prithi Bhathal, Andreas Lopata, Golo Ahlenstiel, Liang Qiao, Jacob George, Lionel Hebbard
Adiponectin demonstrates beneficial effects in various metabolic diseases including diabetes, and in bowel cancer. Recent data also suggests a protective role in colitis. However, the precise molecular mechanisms by which adiponectin and its receptors modulate colitis and the nature of the adaptive immune response in murine models are yet to be elucidated. Adiponectin-knockout mice were orally administered dextran sulfate sodium for 7 days, and were compared to wild-type mice. The severity of disease was analysed histopathologically, and through cytokine profiling...
March 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28258021/sartorius-muscle-flaps-perioperative-outcomes-based-on-surgical-specialty
#9
Tammam Obeid, Satinderjit Locham, Isibor Arhuidese, Besma Nejim, Hanaa D Aridi, Mahmoud Malas
OBJECTIVE: Complicated groin wounds often require repair by Sartorius Muscle Flap (SMF). Operating surgical specialty differs based on SMF indication, hospital, and operating surgeon preference. We aim to assess the effect of operating surgical specialty, indication for SMF, and other patient-level factors on 30-day outcomes. METHODS: We collected data on all patients undergoing SMF performed at our institution from 2005-2015, including age, sex, body mass index, comorbidity index (hypertension, diabetes, dyslipidemia, peripheral arterial disease, coronary artery disease), smoking status, history of malignancy, indication for SMF (infection, non-infectious complication, prophylaxis), and operating surgeon's specialty (vascular, plastic, general, other)...
February 28, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28236920/bovine-carotid-artery-biologic-graft-outperforms-expanded-polytetrafluoroethylene-for-hemodialysis-access
#10
Isibor Arhuidese, Thomas Reifsnyder, Tasnim Islam, Omar Karim, Besma Nejim, Tammam Obeid, Umair Qazi, Mahmoud Malas
OBJECTIVE: Arteriovenous grafts remain reliable substitutes for permanent hemodialysis access in patients without a suitable autogenous conduit. Advances in conduit design and endovascular management of access-related complications question the preference for synthetic conduits over biologic grafts in contemporary practice. In this study, we compared outcomes between a bovine carotid artery (BCA) biologic graft and expanded polytetrafluoroethylene (ePTFE) grafts for hemodialysis access in a recent cohort of patients...
March 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28227900/automated-assessment-of-postural-stability-system
#11
Alessandro Napoli, Christian R Ward, Stephen M Glassd, Carole Tucker, Iyad Obeid, Alessandro Napoli, Christian R Ward, Stephen M Glass, Carole Tucker, Iyad Obeid, Christian R Ward, Carole Tucker, Alessandro Napoli, Iyad Obeid, Stephen M Glass
The Balance Error Scoring System (BESS) is one of the most commonly used clinical tests to evaluate static postural stability deficits resulting from traumatic brain events and musculoskeletal injury. This test requires a trained operator to visually assess balance and give the subject a performance score based on the number of balance "errors" they committed. Despite being regularly used in several real-world situations, the BESS test is scored by clinician observation and is therefore (a) potentially susceptible to biased and inaccurate test scores and (b) cannot be administered in the absence of a trained provider...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226606/applications-of-ubms-and-i-vectors-in-eeg-subject-verification
#12
Christian Ward, Joseph Picone, Iyad Obeid, Christian Ward, Joseph Picone, Iyad Obeid, Christian Ward, Iyad Obeid, Joseph Picone
The processing of electroencephalograms (EEGs) is a growing field where mature speech processing techniques are able to rapidly progress development and understanding of the associated neuroscience. I-vectors and Joint Factor Analysis (JFA), along with their foundational universal background models (UBMs) have progressed to a level of understanding that makes them prime for transition to the EEG community. To prove the capability of these techniques they are tested against two contrasting EEG data sets, PhysioNet's EEG Motor Movement/Imagery Dataset and the Temple University Hospital EEG Corpus, to highlight the effectiveness of the techniques with minimal domain knowledge modifications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28216356/fixed-and-variable-cost-of-carotid-endarterectomy-and-stenting-in-the-united-states-a-comparative-study
#13
Tammam Obeid, Husain Alshaikh, Besma Nejim, Isibor Arhuidese, Satinderjit Locham, Mahmoud Malas
OBJECTIVE: Despite multiple landmark clinical trials, little data exists on real-world cost of carotid artery stenting (CAS) and carotid endarterectomy (CEA) to the United States healthcare system. We aim to study differences in actual hospitalization cost between patients who underwent CAS vs CEA in a nationally representative database. METHODS: We studied hospital discharge and billing records of all patients, in the Premier Perspective Database, who underwent CEA or CAS between the third quarter of 2009 and the first quarter of 2015...
February 16, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28214999/e6-associated-protein-dependent-estrogen-receptor-regulation-of-protein-kinase-a-regulatory-subunit-r2a-expression-in-neuroblastoma
#14
Jean-Pierre Obeid, Youssef H Zeidan, Nawal Zafar, Jimmy El Hokayem
E6ap is a known transcriptional coregulator for estrogen receptor alpha (Er, Erα) in the presence of estrogen. Protein kinase A (PKA) contains two regulatory subunits derived from four genes. Recent evidence demonstrates that PKA regulates E6ap activity. Data generated in our lab indicated estrogen dependent regulation of Pkar2a levels. Our project sets to investigate a possible feedback mechanism constituting of Erα and E6ap transcriptional regulation of Pkar2a expression. Western blot evaluated protein regulation correlations with E2 in mouse neuroblastoma lines...
February 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28190720/endarterectomy-versus-stenting-in-patients-with-prior-ipsilateral-carotid-artery-stenting
#15
Isibor J Arhuidese, Besma Nejim, Susruth Chavali, Satinderjit Locham, Tammam Obeid, Caitlin W Hicks, Mahmoud B Malas
OBJECTIVE: In-stent restenosis is a recognized complication of carotid angioplasty and stenting (CAS), and it is associated with an increased risk of stroke. Few case series have reported outcomes separately following carotid endarterectomy (CEA) and CAS for the treatment of in-stent restenosis. In this study, we perform an evaluation of redo-CAS vs CEA in a large contemporary cohort of patients who underwent prior ipsilateral CAS. METHODS: We studied all patients in the Vascular Quality Initiative (VQI) database, who underwent CEA or CAS between January 1, 2003, and April 30, 2016, after prior ipsilateral CAS...
February 9, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28185152/incidental-finding-of-gastrointestinal-stromal-tumors-during-laparoscopic-sleeve-gastrectomy-in-obese-patients
#16
Germán Viscido, Franco Signorini, Luciano Navarro, Mario Campazzo, Patricia Saleg, Verónica Gorodner, Lucio Obeide, Federico Moser
INTRODUCTION: The frequency of incidental pathology found during laparoscopic bariatric surgery has been estimated to be 2%. Gastrointestinal stromal tumors (GISTs) are infrequent lesions and account for less than 1% of all digestive tract tumors. The reported incidence of this type of tumors during bariatric surgery is around 0.8%. The objective of this study was to evaluate incidence, characteristics, and evolution of incidentally found GISTs in patients undergoing laparoscopic sleeve gastrectomy (LSG) for the treatment of obesity...
February 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28163227/comparison-of-the-physical-characteristics-of-monodisperse-non-ionic-surfactant-vesicles-nisv-prepared-using-different-manufacturing-methods
#17
Mohammad A Obeid, Ayman M Gebril, Rothwelle J Tate, Alexander B Mullen, Valerie A Ferro
Non-ionic surfactant vesicles (NISV) are synthetic membrane vesicles formed by self-assembly of a non-ionic surfactant, often in a mixture with cholesterol and a charged chemical species. Different methods can be used to manufacture NISV, with the majority of these requiring bulk mixing of two phases. This mixing process is time-consuming and leads to the preparation of large and highly dispersed vesicles, which affects the consistency of the final product and could hinder subsequent regulatory approval. In this study, we have compared the physical characteristics of NISV prepared using two conventional methods (thin-film hydration method and heating method) with a recently introduced microfluidic method...
February 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28118574/rapd-and-eric-based-typing-of-clinical-and-environmental-pseudomonas-aeruginosa-isolates
#18
Ibtesam Ghadban Auda, Israa M S Al-Kadmy, Sawsan Mohammed Kareem, Aliaa Khyuon Lafta, Mustafa Hussein Obeid A'Affus, Ibrahim Abd Aloahd Khit, Abdulaziz Abdullah Al Kheraif, Darshan Devang Divakar, Ravikumar Ramakrishnaiah
<em>Pseudomonas aeruginosa</em> is a major cause of nosocomial infection in children and adults, resultingin significant morbidity and mortality due to its ability to acquire drug resistance. The ability of <em>P. aeruginosa</em> in the environment to cause infection in individuals has been reported previously; henceforth, surveillance of the emergence and transmission of <em>P. aeruginosa</em> strains among patients is important for infection control in a clinical setup...
November 30, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/28118270/the-heterogeneity-of-tumor-infiltrating-cd8-t-cells-in-metastatic-melanoma-distorts-their-quantification-how-to-manage-heterogeneity
#19
Joseph M Obeid, Yinin Hu, Gulsun Erdag, Katie M Leick, Craig L Slingluff
CD8 T-cell infiltration of metastatic melanoma may be a useful biomarker for prediction of prognosis and response to therapy. The heterogeneous distribution of CD8 T cells within a single tumor, and across different tumors within a single patient, may complicate quantification of infiltration. However, the impact of heterogeneity has not been quantified sufficiently. To address this, we have assessed intratumoral heterogeneity of CD8 T-cell counts, as well as intertumoral heterogeneity for synchronous and metachronous metastases...
January 21, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28089767/the-correlation-between-a-short-term-conventional-electroencephalography-in-the-first-day-of-life-and-brain-magnetic-resonance-imaging-in-newborns-undergoing-hypothermia-for-hypoxic-ischemic-encephalopathy
#20
Rawad Obeid, Yoshimi Sogawa, Satyanarayana Gedela, Monica Naik, Vince Lee, Richard Telesco, Jessica Wisnowski, Christine Magill, Michael J Painter, Ashok Panigrahy
OBJECTIVE: Electroencephalograph recorded in the first day of life in newborns treated with hypothermia for hypoxic-ischemic encephalopathy could be utilized as a predictive tool for the severity of brain injury on magnetic resonance imaging and mortality. STUDY DESIGN: This work was a retrospective study of newborns who were admitted for therapeutic hypothermia due to hypoxic-ischemic encephalopathy. All enrolled infants underwent encephalography within the first 24 hours of life and underwent brain magnetic resonance imaging after rewarming...
November 3, 2016: Pediatric Neurology
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