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https://www.readbyqxmd.com/read/29165427/sphingolipids-and-their-metabolism-in-physiology-and-disease
#1
REVIEW
Yusuf A Hannun, Lina M Obeid
Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many functions, which rivals, if not exceeds, that of the genome or proteome. These results highlight critical roles for bioactive sphingolipids in most, if not all, major cell biological responses, including all major cell signalling pathways, and they link sphingolipid metabolism to key human diseases. Nevertheless, the fairly nascent field of bioactive sphingolipids still faces challenges in its biochemical and molecular underpinnings, including defining the molecular mechanisms of pathway and enzyme regulation, the study of lipid-protein interactions and the development of cellular probes, suitable biomarkers and therapeutic approaches...
November 22, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29156094/multiple-transmissions-of-chromosomally-integrated-human-herpesvirus-6-in-one-family
#2
Armin Rashidi, Karam Obeid, Joshua Hill, Erica D Warlick, Daniel J Weisdorf
Chromosomally integrated human herpesvirus-6 (ciHHV-6) can be transmitted from parent to child or via allogeneic hematopoietic cell transplantation (HCT). We report a case of ciHHV-6 transmitted via syngeneic HCT, and vertically across three generations. ciHHV-6 was transmitted from a parent to the patient and her identical twin, and from the patient to her son. The patient underwent syngeneic HCT as rescue from chemotherapy-induced aplasia during which ciHHV-6 was re-transmitted to her, this time from her identical twin...
November 20, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29153460/real-world-procedural-and-30-day-outcome-using-the-portico-transcatheter-aortic-valve-prosthesis-a-large-single-center-cohort
#3
Andrea Denegri, Fabian Nietlispach, Jan Kottwitz, Gabor Suetsch, Philipp Haager, Hector Rodriguez, Maurizio Taramasso, Slayman Obeid, Francesco Maisano
BACKGROUND: Published procedural and short-term outcome of the Portico valve for Transcatheter Aortic Valve Implantation (TAVI) is limited. We report a single-center patient series assessing procedural and 30-day outcome of this device. METHODS AND RESULTS: Procedural and 30-day follow-up data were prospectively collected from a consecutive series of 73 patients (80.7±6.9years, 45% male, mean STS score: 4.8±3.9) with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI)...
November 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29143484/response-of-red-blood-cell-folate-to-supplementation-in-non-pregnant-women-is-predictable-a-proposal-for-personalized-supplementation
#4
Rima Obeid, Christiane Schön, Manfred Wilhelm, Rajiv P Shrestha, Stefan Pilz, Klaus Pietrzik
SCOPE: We modelled red blood cell (RBC)-folate response to supplementation and developed personalized folate supplementation concepts. METHODS AND RESULTS: The changes of RBC-folate were modelled in a time- (4 or 8 weeks) and dose- (400 μg/d or 800 μg/d folate) dependent manner. Post-supplementation RBC-folate levels were predicted from folate-loading capacities [ = measured RBC-folate - (baseline RBC-folate * RBC-survival)]. The prediction equations were validated in 119 participants...
November 15, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29143092/laparoscopic-appendectomy-minimally-invasive-surgery-training-improves-outcomes-in-basic-laparoscopic-procedures
#5
Katherine D Gray, Joshua G Burshtein, Lama Obeid, Maureen D Moore, Gregory Dakin, Alfons Pomp, Cheguevara Afaneh
BACKGROUND: To determine whether minimally invasive surgery (MIS) training improves outcomes in laparoscopic appendectomy, a procedure that is commonly performed in general surgery training. METHODS: Retrospective review was conducted of all patients undergoing laparoscopic appendectomy for suspected acute appendicitis between 2014 and 2015 at a single-center, tertiary-care academic institution. Patients operated on by MIS-trained surgeons (MIS group) were compared to those operated on by general surgeons (GS group)...
November 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29141978/cobalamin-status-from-pregnancy-to-early-childhood-lessons-from-global-experience
#6
REVIEW
Rima Obeid, Michelle Murphy, Pol Solé-Navais, Chittaranjan Yajnik
Low cobalamin intake and status during pregnancy or lactation have been linked to adverse maternal and perinatal health outcomes, whereas low cobalamin status during early childhood is associated with impaired development in children. Women who begin pregnancy with depleted stores (low or very low plasma cobalamin) will give birth to depleted infants who are likely to develop deficiency symptoms during the first few weeks or months postpartum. Newly ingested cobalamin during pregnancy and lactation (from diet or supplements) is transferred to the child and is not likely to correct cobalamin status in depleted women...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29133339/decreased-ceramide-underlies-mitochondrial-dysfunction-in-charcot-marie-tooth-2f
#7
Nicholas U Schwartz, Ryan W Linzer, Jean-Philip Truman, Mikhail Gurevich, Yusuf A Hannun, Can E Senkal, Lina M Obeid
Charcot-Marie-Tooth (CMT) disease is the most commonly inherited neurologic disorder, but its molecular mechanisms remain unclear. One variant of CMT, 2F, is characterized by mutations in heat shock protein 27 (Hsp27). As bioactive sphingolipids have been implicated in neurodegenerative diseases, we sought to determine if their dysregulation is involved in CMT. Here, we show that Hsp27 knockout mice demonstrated decreases in ceramide in peripheral nerve tissue and that the disease-associated Hsp27 S135F mutant demonstrated decreases in mitochondrial ceramide...
November 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29118880/occurrence-and-impact-of-time-delay-to-primary-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction
#8
Mohammady Shahin, Slayman Obeid, Lotfy Hamed, Christian Templin, Oliver Gamperli, Fabian Nietlispach, Willbald Maier, Nooraldaem Yousif, Francois Mach, Marco Roffi, Stephan Windecker, Lorenz Raber, Christian M Matter, Thomas F Luscher
Background: The aim of the study was to evaluate the occurrence, duration and impact of time delays to primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI). Methods: A total of 357 consecutive STEMI patients enrolled in the prospective Special Program University Medicine ACS (SPUM-ACS) cohort were included. In order to identify the causes behind a possible treatment delay, we constructed four different time points which included: 1) symptom onset to hospital arrival, 2) hospital arrival to arrival in the catheterization laboratory, 3) hospital arrival to first balloon inflation, and 4) time from arrival in the catheterization laboratory to first balloon inflation in addition to total ischemic time...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29095408/impact-of-iliac-instrumentation-on-the-quality-of-life-of-patients-with-adult-spine-deformity
#9
Mar Pérez Martin-Buitrago, Javier Pizones, Francisco Javier Sánchez Perez-Grueso, Mariana Díaz Almirón, Alba Vila-Casademunt, Ibrahim Obeid, Ahmet Alanay, Frank Kleinstück, Emre R Acaroglu, Ferran Pellisé
STUDY DESIGN: Retrospective comparative analysis of data collected prospectively in an adult spine deformity (ASD) multicenter database. OBJECTIVE: To evaluate the impact of the iliac screws on the quality of life of ASD patients compared with those instrumented above the pelvis (L5/S1/S2). SUMMARY OF BACKGROUND DATA: The impact on patient's daily activities and functions, of immobilizing the sacroiliac joint with iliac screws for the treatment of ASD is still underexplored...
October 31, 2017: Spine
https://www.readbyqxmd.com/read/29092960/quantification-of-3-ketodihydrosphingosine-using-hplc-esi-ms-ms-to-study-spt-activity-in-yeast-saccharomyces-cerevisiae
#10
Jihui Ren, Justin Snider, Michael V Airola, Aaron Zhong, Nadia A Rana, Lina M Obeid, Yusuf A Hannun
Serine palmitoyltransferase (SPT) catalyzes the rate-limiting step of condensation of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine (3KDS). Here we report a HPLC-ESI-MS/MS method to directly quantify 3KDS generated by SPT. With this technique we were able to detect 3KDS at a level comparable to that of dihydrosphingosine (DHS) in yeast S.cerevisiae. An in vitro SPT assay measuring the incorporation of deuterated serine into deuterated 3KDS was developed. The results show that SPT kinetics in response to palmitoyl-CoA fit into an allosteric sigmoidal model, suggesting the existence of more than one palmitoyl-CoA binding site on yeast SPT and positive cooperativity between them...
November 1, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29075895/cerebral-ischaemia-following-anterior-upper-thoracic-spinal-surgery-utilizing-a-partial-manubrial-resection
#11
David Christopher Kieser, Derek Thomas Cawley, Takashi Fujishiro, Cecile Roscop, Louis Boissiere, Ibrahim Obeid, Olivier Gille, Jean-Marc Vital, Vincent Pointillart
PURPOSE: Firstly, to describe two cases of cerebral ischaemia complicating anterior upper thoracic spinal surgery and define the likely cause of this complication. Secondly, to describe preventative measures and the effect these have had in reducing this complication within our institution. METHODS: Firstly, a review of two cases of cerebral ischaemia complicating anterior upper thoracic spinal surgery utilizing a partial manubrial resection. Secondly, cadaveric dissections of the carotid arteries to determine the effect of neck positioning and aortic arch retraction during a simulated procedure...
October 26, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29074114/regional-variation-in-the-cost-of-infra-inguinal-lower-extremity-bypass-surgery-in-the-united-states
#12
Besma J Nejim, Sophie Wang, Isibor Arhuidese, Tammam Obeid, Husain Nader Alshaikh, Hanaa Dakour Aridi, Satinderjit Locham, Mahmoud B Malas
BACKGROUND: Lower extremity bypass (LEB) remains the gold standard revascularization procedure in patients with peripheral arterial disease. The cost of LEB substantially varies based on patient's characteristics and comorbidities. The aim of this study was to assess regional variation in infra-inguinal LEB cost and to identify the specific health care expenditures per service that are associated with the highest cost in each region. METHODS: We identified adult patients who underwent infra-inguinal LEB in the Premier database between June 2009 and March 2015...
October 23, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29061102/delivering-natural-products-and-biotherapeutics-to-improve-drug-efficacy
#13
Mohammad A Obeid, Mohammed M Al Qaraghuli, Manal Alsaadi, Abdullah R Alzahrani, Kanidta Niwasabutra, Valerie A Ferro
Due to the increasing problem of drug resistance, new and improved medicines are required. Natural products and biotherapeutics offer a vast resource for new drugs; however, challenges, including the cost and time taken for traditional drug discovery processes and the subsequent lack of investment from the pharmaceutical industry, are associated with these areas. New techniques are producing compounds with appropriate activity at a faster rate. While the formulation of these combined with drug-delivery systems offers a promising approach for expanding the drug developments available to modern medicine...
November 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/29059837/cranial-ultrasound-based-prediction-of-post-hemorrhagic-hydrocephalus-outcome-in-premature-neonates-with-intraventricular-hemorrhage
#14
Pooneh R Tabrizi, Rawad Obeid, Awais Mansoor, Scott Ensel, Juan J Cerrolaza, Anna Penn, Marius George Linguraru
Premature neonates with intraventricular hemorrhage (IVH) followed by post hemorrhagic hydrocephalus (PHH) are at high risk for brain injury. Cranial ultrasound (CUS) is used for monitoring of premature neonates during the first weeks after birth to identify IVH and follow the progression to PHH. However, the lack of a standardized method for CUS evaluation has led to significant variability in decision making regarding treatment. We propose a quantitative imaging tool for the evaluation of PHH on CUS for premature neonates based on morphological features of the cerebral ventricles...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056331/alkaline-ceramidase-1-protects-mice-from-premature-hair-loss-by-maintaining-the-homeostasis-of-hair-follicle-stem-cells
#15
Chih-Li Lin, Ruijuan Xu, Jae Kyo Yi, Fang Li, Jiang Chen, Evan C Jones, Jordan B Slutsky, Liqun Huang, Basil Rigas, Jian Cao, Xiaoming Zhong, Ashley J Snider, Lina M Obeid, Yusuf A Hannun, Cungui Mao
Ceramides and their metabolites are important for the homeostasis of the epidermis, but much remains unknown about the roles of specific pathways of ceramide metabolism in skin biology. With a mouse model deficient in the alkaline ceramidase (Acer1) gene, we demonstrate that ACER1 plays a key role in the homeostasis of the epidermis and its appendages by controlling the metabolism of ceramides. Loss of Acer1 elevated the levels of various ceramides and sphingoid bases in the skin and caused progressive hair loss in mice...
November 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29052780/immunotherapy-for-hepatocellular-carcinoma-patients-is-it-ready-for-prime-time
#16
REVIEW
Joseph M Obeid, Paul R Kunk, Victor M Zaydfudim, Timothy N Bullock, Craig L Slingluff, Osama E Rahma
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the second most common cause of cancer death worldwide. Current treatment options for patients with intermediate and advanced HCC are limited, and there is an unmet need for novel therapeutic approaches. HCC is an attractive target for immunomodulation therapy, since it arises in an inflammatory milieu due to hepatitis B and C infections and cirrhosis. However, a major barrier to the development and success of immunotherapy in patients with HCC is the liver's inherent immunosuppressive function...
October 20, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29040468/from-eisenhower-s-heart-attack-to-modern-management-a-true-success-story
#17
Thomas F Lüscher, Slayman Obeid
No abstract text is available yet for this article.
November 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29037974/impact-of-early-unanticipated-revision-surgery-on-health-related-quality-of-life-after-adult-spinal-deformity
#18
Susana Núñez-Pereira, Alba Vila-Casademunt, Montse Domingo-Sàbat, Juan Bagó, Emre R Acaroglu, Ahmet Alanay, Ibrahim Obeid, Francisco Javier Sánchez Pérez-Grueso, Frank Kleinstück, Ferran Pellisé
Background context Revision surgery represents a major event for patients undergoing ASD surgery. Previous reports suggest minimal or no impact on HRQOL outcomes. Purpose To investigate the impact of early reoperations within the first year on health-related quality of life (HRQOL) and on the likelihood of reaching the MCID after ASD surgery. Design Retrospective analysis of prospectively collected data from consecutive surgically treated adult deformity surgery (ADS) patients included in a multicenter, international database...
October 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29028945/sphingosine-kinase-1-expression-in-peritoneal-macrophages-is-required-for-colon-carcinogenesis
#19
Hideki Furuya, Paulette M Tamashiro, Yoshiko Shimizu, Kayoko Iino, Rafael Peres, Runpu Chen, Yijun Sun, Yusuf A Hannun, Lina M Obeid, Toshihiko Kawamori
Accumulating evidence suggests that the sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) pathway plays a pivotal role in colon carcinogenesis. Our previous studies indicate that the SphK1/S1P pathway mediates colon carcinogenesis at least by regulating COX-2 expression and prostaglandin E2 (PGE2) production. However, the mechanisms by which this pathway regulates colon carcinogenesis are still unclear. First, we show that SphK1 deficient mice significantly attenuated azoxymethane (AOM)-induced colon carcinogenesis as measured by colon tumor incidence, multiplicity, and volume...
September 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29022042/erratum-to-delayed-post-operative-tension-pneumocephalus-and-pneumorrhachis
#20
D C Kieser, D T Cawley, C Tavolaro, T Cloche, C Roscop, L Boissiere, I Obeid, V Pointillart, J M Vital, O Gille
Unfortunately, two author names were missed out in author group of the original publication.
October 11, 2017: European Spine Journal
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