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https://www.readbyqxmd.com/read/27916380/contemporary-outcomes-of-open-thoracoabdominal-aneurysm-repair-functional-status-is-the-strongest-predictor-of-perioperative-mortality
#1
Tammam Obeid, Caitlin W Hicks, Kanhua Yin, Isibor Arhuidese, Besma Nejim, Arman Kilic, James H Black, Mahmoud Malas
BACKGROUND: Open repair of thoracoabdominal and descending thoracic aneurysm (TAA) carries significant operative morbidity and mortality. Despite evolving operative techniques patient-level risk factors affecting mortality after open TAA repair, including patient functional status, remain to be fully understood. MATERIALS AND METHODS: We identified all open TAA repair cases in the National Surgical Quality Improvement Program database between 2005 and 2013. Multivariable logistic regression was used to evaluate the effect of patients' age, gender, race, body mass index (BMI), comorbid conditions, functional status, ASA class, smoking, rupture, descending thoracic aneurysm versus Crawford types, dissection, and preoperative: transfusion, creatinine levels, on perioperative (30-d) mortality after open TAA repair...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27906189/distinct-outcomes-of-crl-nedd8-pathway-inhibition-reveal-cancer-cell-plasticity
#2
Anastasia V Rulina, Frédérique Mittler, Patricia Obeid, Sophie Gerbaud, Laurent Guyon, Eric Sulpice, Frédérique Kermarrec, Nicole Assard, Monika E Dolega, Xavier Gidrol, Maxim Y Balakirev
Inhibition of protein degradation by blocking Cullin-RING E3 ligases (CRLs) is a new approach in cancer therapy though of unknown risk because CRL inhibition may stabilize both oncoproteins and tumor suppressors. Probing CRLs in prostate cancer cells revealed a remarkable plasticity of cells with TMPRSS2-ERG translocation. CRL suppression by chemical inhibition or knockdown of RING component RBX1 led to reversible G0/G1 cell cycle arrest that prevented cell apoptosis. Conversely, complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL regulator Cand1...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27866974/sphingolipids-in-neutrophil-function-and-inflammatory-responses-mechanisms-and-implications-for-intestinal-immunity-and-inflammation-in-ulcerative-colitis
#3
REVIEW
Mel Pilar Espaillat, Richard R Kew, Lina M Obeid
Bioactive sphingolipids are regulators of immune cell function and play critical roles in inflammatory conditions including ulcerative colitis. As one of the major forms of inflammatory bowel disease, ulcerative colitis pathophysiology is characterized by an aberrant intestinal inflammatory response that persists causing chronic inflammation and tissue injury. Innate immune cells play an integral role in normal intestinal homeostasis but their dysregulation is thought to contribute to the pathogenesis of ulcerative colitis...
November 14, 2016: Advances in Biological Regulation
https://www.readbyqxmd.com/read/27864681/are-sagittal-spinopelvic-radiographic-parameters-significantly-associated-with-quality-of-life-of-adult-spinal-deformity-patients-multivariate-linear-regression-analyses-for-pre-operative-and-short-term-post-operative-health-related-quality-of-life
#4
Mitsuru Takemoto, Louis Boissière, Jean-Marc Vital, Ferran Pellisé, Francisco Javier Sanchez Perez-Grueso, Frank Kleinstück, Emre R Acaroglu, Ahmet Alanay, Ibrahim Obeid
PURPOSE: To evaluate the association in ASD patients between spinopelvic sagittal parameters and health-related quality of life (HRQL), adjusted for demographic and surgical variables. METHODS: We constructed multiple linear regression models to investigate pre-operative (PreOp) and 6-month post-operative (PostOp) HRQL as assessed by the Oswestry Disability Index (ODI), with sagittal parameters as independent variables adjusted for potential confounders, such as age, sex, body mass index, past spine surgery, types of surgical treatment, and complications...
November 18, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27836752/the-effects-of-hydration-media-on-the-characteristics-of-non-ionic-surfactant-vesicles-nisv-prepared-by-microfluidics
#5
Mohammad A Obeid, Ibrahim Khadra, Alexander B Mullen, Rothwelle J Tate, Valerie A Ferro
Non-ionic surfactant vesicles (NISV) are colloidal particles that provide a useful delivery system for drugs and vaccines. One of the methods that is used for NISV preparation is microfluidics in which the lipid components dissolved in organic phase are mixed with an aqueous medium to prepare the particles through self-assembly of the lipids. In this work, we examined the effect of using different types of aqueous media on the characteristics of the NISV prepared by microfluidics. Five aqueous media were tested: phosphate buffered saline, HEPES buffer, Tris buffer, normal saline and distilled water...
November 9, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27822565/teleconsent-a-novel-approach-to-obtain-informed-consent-for-research
#6
Brandon M Welch, Elizabeth Marshall, Suparna Qanungo, Ayesha Aziz, Marilyn Laken, Leslie Lenert, Jihad Obeid
Lack of recruitment of qualified research participants continues to be a significant bottleneck in clinical trials, often resulting in costly time extensions, underpowered results, and in some cases early termination. Some of the reasons for suboptimal recruitment include laborious consent processes and access to participants at remote locations. While new electronic consents technologies (eConsent) help overcome challenges related to readability and consent management, they do not adequately address challenges related to remote access...
August 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/27815217/global-tilt-and-lumbar-lordosis-index-two-parameters-correlating-with-health-related-quality-of-life-scores-but-how-do-they-truly-impact-disability
#7
L Boissière, M Takemoto, A Bourghli, J M Vital, F Pellisé, A Alanay, C Yilgor, E Acaroglu, F J Perez-Grueso, F Kleinstück, I Obeid
BACKGROUND CONTEXT: Many radiological parameters have been reported to correlate with patient's disability including sagittal vertical axis (SVA), pelvic tilt (PT), and pelvic incidence minus lumbar lordosis (PI-LL). European literature reports other parameters such as lumbar lordosis index (LLI) and the global tilt (GT). If most parameters correlate with health-related quality of life scores (HRQLs), their impact on disability remains unclear. PURPOSE: This study aimed to validate these parameters by investigating their correlation with HRQLs...
November 1, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27807146/scientific-retreats-with-speed-dating-networking-to-stimulate-new-interdisciplinary-translational-research-collaborations-and-team-science
#8
Damayanthi Ranwala, Anthony J Alberg, Kathleen T Brady, Jihad S Obeid, Randal Davis, Perry V Halushka
To stimulate the formation of new interdisciplinary translational research teams and innovative pilot projects, the South Carolina Clinical and Translational Research (SCTR) Institute (South Carolina Clinical and Translational Science Award, CTSA) initiated biannual scientific retreats with 'speed dating' networking sessions. Retreat themes were prioritized based on the following criteria; cross-cutting topic, unmet medical need, generation of novel technologies and methodologies. Each retreat begins with an external keynote speaker followed by a series of brief research presentations by local researchers focused on the retreat theme, articulating potential areas for new collaborations...
November 2, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27801724/attachment-style-and-obesity-disordered-eating-behaviors-as-a-mediator-in-a-community-sample-of-canadian-youth
#9
Danijela Maras, Nicole Obeid, Martine Flament, Annick Buchholz, Katherine A Henderson, Mary Gick, Gary S Goldfield
OBJECTIVE: Obesity and overweight are associated with many negative health outcomes. Attachment style has been implicated in the development of obesity in youth. The present study examined if disordered eating behaviors mediate the relationship between attachment style and body mass index (BMI) in a large community sample of Canadian youth. METHOD: A total of 3,043 participants (1,254 males and 1,789 females, Mage = 14.20 years) completed self-report questionnaires including the Relationship Questionnaire and the Dutch Eating Behavior Questionnaire, and BMI was objectively measured...
November 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27798411/is-the-adjustable-gastric-band-dead
#10
Nabeel R Obeid, Aurora D Pryor
No abstract text is available yet for this article.
October 28, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27776328/determination-of-trimethylamine-trimethylamine-n-oxide-and-taurine-in-human-plasma-and-urine-by-uhplc-ms-ms-technique
#11
Hussain Mohamad Awwad, Juergen Geisel, Rima Obeid
BACKGROUND: Trimethylamine-N-oxide (TMAO) is produced in the liver from trimethylamine (TMA) and is an important cellular osmolyte and potential atherogenic factor. Taurine is involved in cholesterol metabolism and also serves as a cellular osmolyte. Given their significant biological functions, the development of reliable measurement techniques is crucial to further study their role in health and disease METHODS: A new ultrahigh performance liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous determination of TMA, TMAO, and taurine in plasma and urine...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27770170/heterogeneity-of-cd8-tumor-infiltrating-lymphocytes-in-non-small-cell-lung-cancer-impact-on%C3%A2-patient-prognostic-assessments-and-comparison-of-quantification-by-different-sampling-strategies
#12
Joseph M Obeid, Nolan A Wages, Yinin Hu, Donna H Deacon, Craig L Slingluff
INTRODUCTION: Infiltration of non-small-cell lung cancer (NSCLC) by CD8(+) T lymphocytes predicts improved patient survival; however, heterogeneity of intratumoral localization complicates this assessment. Strategies for tumor sampling may not accurately represent the whole tumor. We hypothesized that sampling strategies may alter the identification of tumors with high CD8 density and affect the prognostic significance. PATIENTS AND METHODS: Twenty-three primary NSCLC tumors were immunohistochemically stained for CD8 and were assessed using automated software with eight different sampling strategies or the whole tumor...
October 21, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27758891/signal-oriented-pathway-analyses-reveal-a-signaling-complex-as-a-synthetic-lethal-target-for-p53-mutations
#13
Songjian Lu, Chunhui Cai, Gonghong Yan, Zhuan Zhou, Yong Wan, Vicky Chen, Lujia Chen, Gregory F Cooper, Lina M Obeid, Yusuf A Hannun, Adrian V Lee, Xinghua Lu
Defining processes that are synthetic lethal with p53 mutations in cancer cells may reveal possible therapeutic strategies. In this study, we report the development of a signal-oriented computational framework for cancer pathway discovery in this context. We applied our bipartite graph-based functional module discovery algorithm to identify transcriptomic modules abnormally expressed in multiple tumors, such that the genes in a module were likely regulated by a common, perturbed signal. For each transcriptomic module, we applied our weighted k-path merge algorithm to search for a set of somatic genome alterations (SGA) that likely perturbed the signal, that is, the candidate members of the pathway that regulate the transcriptomic module...
December 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27749457/treatment-effects-on-neonatal-eeg
#14
Rawad Obeid, Tammy N Tsuchida
Conventional EEG and amplitude-integrated electroencephalography are used in neonates to assess prognosis and significant changes in brain activity. Neuroactive medications and hypothermia can influence brain activity and therefore alter EEG interpretation. There are limited studies on the effect of these therapies on neonatal EEG background activity. Medication effects on the EEG or amplitude-integrated electroencephalography include increased interburst interval duration, voltage suppression, and sleep disruption...
October 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27707617/stenting-versus-endarterectomy-after-prior-ipsilateral-carotid-endarterectomy
#15
Isibor Arhuidese, Tammam Obeid, Besma Nejim, Satinderjit Locham, Caitlin W Hicks, Mahmoud B Malas
BACKGROUND: Restenosis after carotid endarterectomy (CEA) is associated with an increased risk of stroke, and the management of critical or symptomatic restenotic lesions poses a treatment challenge. The superiority of CEA vs carotid angioplasty and stenting (CAS) for restenosis remains debatable because existing studies are few and limited by small sample size or the inability to align interventions with ipsilateral events beyond the periprocedural period. We performed a population-based evaluation of CEA vs CAS in a large contemporary cohort of patients with carotid artery restenosis...
October 1, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27700208/first-trimester-serum-levels-of-the-soluble-transcobalamin-receptor-holo-transcobalamin-and-total-transcobalamin-in-relation-to-preeclampsia-risk
#16
Omar Abuyaman, Niels Torring, Rima Obeid, Ebba Nexo
BACKGROUND: Human placenta expresses CD320, a receptor that ensures the uptake of holo-transcobalamin (holoTC). Soluble CD320 (sCD320) is present in the circulation and its concentration increases during pregnancy. AIMS: To investigate a possible association of sCD320, holoTC and total transcobalamin (TC) with the risk of subsequent preeclampsia using serum samples from asymptomatic first trimester pregnant women. Moreover, we aimed to establish reference intervals of the aforementioned biomarkers for first trimester pregnant women who remained healthy throughout pregnancy...
December 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27697478/sphingolipids-in-mitochondria
#17
REVIEW
María José Hernández-Corbacho, Mohamed F Salama, Daniel Canals, Can E Senkal, Lina M Obeid
Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal transduction. In recent years, it has become apparent that sphingolipids participate in growth, senescence, differentiation and apoptosis. The anabolism and catabolism of sphingolipids occur in discrete subcellular locations and consist of a strictly regulated and interconnected network, with ceramide as the central hub. Altered sphingolipid metabolism is linked to several human diseases. Hence, an advanced knowledge of how and where sphingolipids are metabolized is of paramount importance in order to understand the role of sphingolipids in cellular functions...
January 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27688896/sodium-glucose-co-transporter-2-inhibitors-in-patients-with-resistant-hypertension-a-case-study
#18
Amira Obeid, Mark Pucci, Una Martin, Wasim Hanif
Sodium glucose co-transporter 2 inhibitors lower blood pressure by osmotic diuresis and can be considered in diabetic patients with resistant hypertension.
September 2016: JRSM Open
https://www.readbyqxmd.com/read/27649848/intracardiac-versus-transesophageal-echocardiography-for-left-atrial-appendage-occlusion-with-watchman
#19
Antonio H Frangieh, Jasmina Alibegovic, Christian Templin, Oliver Gaemperli, Slayman Obeid, Robert Manka, Erik W Holy, Willibald Maier, Thomas F Lüscher, Ronald K Binder
BACKGROUND: Left atrial appendage occlusion (LAAO) is mostly performed by transesophageal echocardiography (TEE) guidance. Intracardiac echocardiography (ICE) may be an alternative imaging modality for LAAO that precludes the need for general anesthesia or sedation. METHODS AND RESULTS: All consecutive single center, single operator LAAO candidates were analyzed. Baseline clinical and procedural characteristics and in-hospital outcomes were compared between patients in whom a Watchman was implanted with ICE vs...
September 21, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27609772/role-of-neutral-ceramidase-in-colon-cancer
#20
Mónica García-Barros, Nicolas Coant, Toshihiko Kawamori, Masayuki Wada, Ashley J Snider, Jean-Philip Truman, Bill X Wu, Hideki Furuya, Christopher J Clarke, Agnieszka B Bialkowska, Amr Ghaleb, Vincent W Yang, Lina M Obeid, Yusuf A Hannun
Alterations in sphingolipid metabolism, especially ceramide and sphingosine 1-phosphate, have been linked to colon cancer, suggesting that enzymes of sphingolipid metabolism may emerge as novel regulators and targets in colon cancer. Neutral ceramidase (nCDase), a key enzyme in sphingolipid metabolism that hydrolyzes ceramide into sphingosine, is highly expressed in the intestine; however, its role in colon cancer has not been defined. Here we show that molecular and pharmacological inhibition of nCDase in colon cancer cells increases ceramide, and this is accompanied by decreased cell survival and increased apoptosis and autophagy, with minimal effects on noncancerous cells...
December 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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