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https://www.readbyqxmd.com/read/28441388/a-population-based-approach-for-implementing-change-from-opt-out-to-opt-in-research-permissions
#1
Elizabeth A Marshall, Jim C Oates, Azza Shoaibi, Jihad S Obeid, Melissa L Habrat, Robert W Warren, Kathleen T Brady, Leslie A Lenert
Due to recently proposed changes in the Common Rule regarding the collection of research preferences, there is an increased need for efficient methods to document opt-in research preferences at a population level. Previously, our institution developed an opt-out paper-based workflow that could not be utilized for research in a scalable fashion. This project was designed to demonstrate the feasibility of implementing an electronic health record (EHR)-based active opt-in research preferences program. The first phase of implementation required creating and disseminating a patient questionnaire through the EHR portal to populate discreet fields within the EHR indicating patients' preferences for future research study contact (contact) and their willingness to allow anonymised use of excess tissue and fluid specimens (biobank)...
2017: PloS One
https://www.readbyqxmd.com/read/28437244/second-transcatheter-closure-for-residual-shunt-following-percutaneous-closure-of-patent-foramen-ovale
#2
Njomeza Susuri, Slayman Obeid, Mirjam Ulmi, George Cm Siontis, Andreas Wahl, Stephan Windecker, Fabian Nietlispach, Bernhard Meier, Fabien Praz
AIMS: Residual shunt following percutaneous patent foramen ovale (PFO) closure has been described in up to 49% of the patients and is associated with recurrent cerebrovascular events. Our aim was to evaluate the safety, feasibility, and mid-term outcomes of transcatheter residual shunt closure. METHODS AND RESULTS: From 1994 to July 2016, 2679 patients underwent transcatheter PFO closure for treatment of presumed paradoxical embolism at our institution. Among them, 100 patients (3...
April 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28418452/multigene-panel-testing-and-breast-cancer-risk-is-it-time-to-scale-down
#3
Elias I Obeid, Michael J Hall, Mary B Daly
No abstract text is available yet for this article.
April 13, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28414327/a-novel-antibody-against-cancer-stem-cell-biomarker-dclk1-s-is-potentially-useful-for-assessing-colon-cancer-risk-after-screening-colonoscopy
#4
Shubhashish Sarkar, Vsevolod L Popov, Malaney R O'Connell, Heather L Stevenson, Brian S Lee, Robert A Obeid, Gurinder K Luthra, Pomila Singh
DCLK1 expression is critically required for maintaining growth of human colon cancer cells (hCCCs). Human colorectal tumors (CRCs) and hCCCs express a novel short isoform of DCLK1 (DCLK1-S; isoform 2) from β-promoter of hDCLK1 gene, while normal colons express long isoform (DCLK1-L; isoform 1) from 5'(α)-promoter, suggesting that DCLK1-S, and not DCLK1-L, marks cancer stem cells (CSCs). Even though DCLK1-S differs from DCLK1-L by only six amino acids, we succeeded in generating a monospecific DCLK1-S-Antibody (PS41014), which does not cross-react with DCLK1-L, and specifically detects CSCs...
April 17, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28410828/early-onset-symptomatic-neuropathy-in-a-child-with-type-1-diabetes-mellitus
#5
Obeid Mohammad Shafi, Muzamil Latief
Diabetic neuropathy (DN) is a major complication of Type 1 Diabetes Mellitus (T1DM). It is usually subclinical in childhood, but can cause significant impairment with its progression through to adulthood. Current guidelines vary in their recommendation regarding screening for DN in children with T1DM, with some advocating starting screening 5 years after the diagnosis of T1DM. Clinical assessment comprising of history and neurological examination is the most commonly used method for screening, though Nerve Conduction Studies (NCS) provide better sensitivity in picking up early subclinical diabetic neuropathy...
April 5, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28409192/can-local-radiotherapy-and-il-12-synergise-to-overcome-the-immunosuppressive-tumor-microenvironment-and-allow-in-situ-tumor-vaccination
#6
Gaël Deplanque, Keyvan Shabafrouz, Michel Obeid
The abscopal effect, which is the spontaneous regression of tumors or metastases outside the radiation field, occurs rarely in cancer patients. Interestingly, radiotherapy (RT) triggers an immunogenic cell death (ICD) that is able to generate tumor-specific cytotoxic CD8(+) T cells that are efficient in killing cancer cells. The key question is: why is this "abscopal effect" so uncommon in cancer patients treated with RT? Most probably, the main reason may be related to the highly immunosuppressive tumor microenvironment of well-established tumors that constantly antagonizes the anti-tumor immune responses triggered by RT...
April 13, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28387780/-oligo-aromatic-species-with-one-or-two-conjugated-si-double-bond-length-as-m-dash-si-bonds-near-ir-emission-of-anthracenyl-bridged-tetrasiladiene
#7
Naim M Obeid, Lukas Klemmer, Daniel Maus, Michael Zimmer, Jonathan Jeck, Iulia Bejan, Andrew J P White, Volker Huch, Gregor Jung, David Scheschkewitz
A series of aryl disilenes Tip2Si[double bond, length as m-dash]Si(Tip)Ar (2a-c) and para-arylene bridged tetrasiladienes, Tip2Si[double bond, length as m-dash]Si(Tip)-LU-Si(Tip)[double bond, length as m-dash]SiTip2 (3a-d) are synthesized by the transfer of the Tip2Si[double bond, length as m-dash]SiTip unit to aryl halides and dihalides by nucleophilic disilenides Tip2Si[double bond, length as m-dash]SiTipLi (Tip = 2,4,6-iPr3C6H2, Ar = aryl substituent, LU = para-arylene linking unit). The scope of the nucleophilic Si[double bond, length as m-dash]Si transfer reaction is demonstrated to also include substrates of considerable steric bulk such as mesityl or duryl halides Ar-X (Ar = Mes = 2,4,6-Me3C6H2; Ar = Dur = 2,3,5,6-Me4C6H, X = Br or I)...
April 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28379892/evaluation-of-arterial-stiffness-by-finger-toe-pulse-wave-velocity-optimization-of-signal-processing-and-clinical-validation
#8
Hasan Obeid, Hakim Khettab, Louise Marais, Magid Hallab, Stéphane Laurent, Pierre Boutouyrie
BACKGROUND: Carotid-femoral pulse wave velocity (PWV) (cf-PWV) is the gold standard for measuring aortic stiffness. Finger-toe PWV (ft-PWV) is a simpler noninvasive method for measuring arterial stiffness. Although the validity of the method has been previously assessed, its accuracy can be improved. ft-PWV is determined on the basis of a patented height chart for the distance and the pulse transit time (PTT) between the finger and the toe pulpar arteries signals (ft-PTT). METHOD: The objective of the first study, performed in 66 patients, was to compare different algorithms (intersecting tangents, maximum of the second derivative, 10% threshold and cross-correlation) for determining the foot of the arterial pulse wave, thus the ft-PTT...
April 4, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28377281/novel-sphingosine-kinase-1-inhibitor-lcl351-reduces-immune-responses-in-murine-dss-induced-colitis
#9
Michael J Pulkoski-Gross, Joachim D Uys, K Alexa Orr-Gandy, Nicolas Coant, Agnieszka B Bialkowska, Zdzislaw M Szulc, Aiping Bai, Alicja Bielawska, Danyelle M Townsend, Yusuf A Hannun, Lina M Obeid, Ashley J Snider
Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid metabolite which has been implicated in many diseases including cancer and inflammatory diseases. Recently, sphingosine kinase 1 (SK1), one of the isozymes which generates S1P, has been implicated in the development and progression of inflammatory bowel disease (IBD). Based on our previous work, we set out to determine the efficacy of a novel SK1 selective inhibitor, LCL351, in a murine model of IBD. LCL351 selectively inhibits SK1 both in vitro and in cells...
April 2, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28361369/lack-of-improvement-in-health-related-quality-of-life-hrqol-scores-6%C3%A2-months-after-surgery-for-adult-spinal-deformity-asd-predicts-high-revision-rate-in-the-second-postoperative-year
#10
Anouar Bourghli, Louis Boissiere, Daniel Larrieu, Jean-Marc Vital, Caglar Yilgor, Ferran Pellisé, Ahmet Alanay, Emre Acaroglu, Francisco-Javier Perez-Grueso, Franck Kleinstück, Ibrahim Obeid
PURPOSE: ASD is assessed radiologically with the spinopelvic parameters and clinically with HRQOL scores. The revision rate after ASD surgery is high and usually occurs during the first or second postoperative year. The aim of this study is to find clinical or radiological factors that could predict revision surgery in the second postoperative year. MATERIALS AND METHODS: Inclusion criterion: ASD patients operated on by instrumented posterior fusion with more than 2 years follow-up were enrolled prospectively...
March 30, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28350553/impact-of-allogeneic-hematopoietic-stem-cell-transplantation-on-the-hiv-reservoir-and-immune-response-in-three-hiv-infected-individuals
#11
K K Koelsch, T A Rasmussen, W J Hey-Nguyen, C Pearson, Y Xu, M Bailey, K H Marks, S C Sasson, M S Taylor, R Tantau, S Obeid, B Milner, C O Morrissey, A N Pinto, K Suzuki, M P Busch, S M Keating, P Kaiser, S Yukl, J K Wong, B M Hiener, S Palmer, J Zaunders, J J Post, D J Chan, S Avery, S T Milliken, A D Kelleher, S R Lewin, D A Cooper
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterisation of HIV infected patients undergoing HSCT is warranted. METHODS: We studied three patients who underwent HSCT after either reduced intensity conditioning or myeloablative conditioning regimen. We measured HIV antigens and antibodies (Ag/Ab), HIV specific CD4+ T cell responses, HIV RNA and DNA in plasma, peripheral blood mononuclear cells (PBMCs), isolated CD4+ T cells from peripheral blood and lymph node cells...
March 24, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28287825/quantification-of-residual-germinal-center-activity-and-hiv-1-dna-and-rna-levels-using-fine-needle-biopsies-of-lymph-nodes-during-antiretroviral-therapy
#12
William J Hey-Nguyen, Yin Xu, Chester F Pearson, Michelle Bailey, Kazuo Suzuki, Robyn Tantau, Solange Obeid, Brad Milner, Andrew Field, Andrew Carr, Mark Bloch, David A Cooper, Anthony D Kelleher, John J Zaunders, Kersten K Koelsch
HIV-1 reservoirs are most often studied in peripheral blood (PB), but not all lymphocytes recirculate, particularly T follicular helper (Tfh) CD4(+) T cells, as well as germinal center (GC) B cells, in lymph nodes (LNs). Ultrasound-guided fine needle biopsies (FNBs) from inguinal LNs and PB samples were obtained from 10 healthy controls (HCs) and 21 HIV-1-infected subjects [11 antiretroviral therapy (ART) naive and 10 on ART]. Tfh cells and GC B cells were enumerated by flow cytometry. HIV-1 DNA and cell-associated (CA) RNA levels in LNs and PB were quantified by real-time polymerase chain reaction...
March 13, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28285031/evolution-and-complications-after-surgery-for-spine-deformation-in-patients-with-parkinson-s-disease
#13
Bouyer Benjamin, Scemama Caroline, P Roussouly, F Laouissat, I Obeid, L Boissière, F-H Parent, S Schuller, J-P Steib, H Pascal-Moussellard, P Guigui, Wolff Stéphane, Riouallon Guillaume
INTRODUCTION: Surgical treatment of spinal deformity is high risk in patients suffering from Parkinson's disease (PD). Several series have already reported a high rate of complications. However, none of these studies included more than 40 patients and none of the risk factors of complications were described. The aim of this study was to describe the rate and risk factors of revision surgery as well as the clinical outcome at the last visit in a large multicenter study of PD patients operated for spinal deformities...
March 8, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28283362/syntax-score-ii-in-patients-with-coronary-artery-disease-undergoing-percutaneous-mitral-repair-with-the-mitraclip
#14
Slayman Obeid, Adrian Attinger-Toller, Maurizio Taramasso, Giovanni Pedrazzini, Gabor Suetsch, Fabienne Landolt, Fatih Karbeyaz, Hector Rodriguez, Daniel Sürder, Tiziano Moccetti, Fabian Nietlispach, Francesco Maisano
BACKGROUND: Percutaneous mitral valve repair (PMVR) using the MitraClip™ system has become a valuable alternative in patients with severe mitral regurgitation (MR) and high surgical risk. We sought to evaluate the prognostic value of the SYNTAX II score (SSII) in patients with concomitant coronary artery disease (CAD) undergoing a Mitraclip procedure. METHODS: In seventy-five consecutive patients who underwent PMVR at the University Heart Center Zürich and the Cardiocentro Ticino, the SSSII was calculated at baseline...
February 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28280688/management-of-anastomosis-leakage-post-ralp-a-simple-trick-for-a-complex-situation
#15
Romain Diamand, Walid Al Hajj Obeid, Anna Accarain, Ksenija Limani, Eric Hawaux, Roland van Velthoven, Alexandre Peltier
A case of 74 years old male patient who underwent RALP with bladder neck reconstruction. Persistent vesicourethral anastomotic leak was seen at cystography. A self-made side fenestrated Foley catheter was used and on the day after, a complete reversal in fluid output between the Foley catheter and the drain was seen.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28273483/ceramide-is-metabolized-to-acylceramide-and-stored-in-lipid-droplets
#16
Can E Senkal, Mohamed F Salama, Ashley J Snider, Janet J Allopenna, Nadia A Rana, Antonius Koller, Yusuf A Hannun, Lina M Obeid
In an approach aimed at defining interacting partners of ceramide synthases (CerSs), we found that fatty acyl-CoA synthase ACSL5 interacts with all CerSs. We demonstrate that ACSL5-generated FA-CoA was utilized with de novo ceramide for the generation of acylceramides, poorly studied ceramide metabolites. Functionally, inhibition of ceramide channeling to acylceramide enhanced accumulation of de novo ceramide and resulted in augmentation of ceramide-mediated apoptosis. Mechanistically, we show that acylceramide generation is catalyzed by diacylglycerol acyltransferase 2 (DGAT2) on lipid droplets...
March 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28269642/automated-assessment-of-postural-stability-system
#17
Alessandro Napoli, Christian R Ward, Stephen M Glass, Carole Tucker, Iyad Obeid
The Balance Error Scoring System (BESS) is one of the most commonly used clinical tests to evaluate static postural stability deficits resulting from traumatic brain events and musculoskeletal injury. This test requires a trained operator to visually assess balance and give the subject a performance score based on the number of balance "errors" they committed. Despite being regularly used in several real-world situations, the BESS test is scored by clinician observation and is therefore (a) potentially susceptible to biased and inaccurate test scores and (b) cannot be administered in the absence of a trained provider...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268436/applications-of-ubms-and-i-vectors-in-eeg-subject-verification
#18
Christian Ward, Joseph Picone, Iyad Obeid
The processing of electroencephalograms (EEGs) is a growing field where mature speech processing techniques are able to rapidly progress development and understanding of the associated neuroscience. I-vectors and Joint Factor Analysis (JFA), along with their foundational universal background models (UBMs) have progressed to a level of understanding that makes them prime for transition to the EEG community. To prove the capability of these techniques they are tested against two contrasting EEG data sets, PhysioNet's EEG Motor Movement/Imagery Dataset and the Temple University Hospital EEG Corpus, to highlight the effectiveness of the techniques with minimal domain knowledge modifications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258220/adiponectin-confers-protection-from-acute-colitis-and-restricts-a-b-cell-immune-response
#19
Stephanie Obeid, Miriam Wankell, Berenice Charrez, Jade Sternberg, Roxane Kreuter, Saeed Esmaili, Mehdi Ramezani-Moghadam, Carol Devine, Scott Read, Prithi Bhathal, Andreas Lopata, Golo Ahlensteil, Liang Qiao, Jacob George, Lionel Hebbard
Adiponectin demonstrates beneficial effects in various metabolic diseases, including diabetes, and in bowel cancer. Recent data also suggest a protective role in colitis. However, the precise molecular mechanisms by which adiponectin and its receptors modulate colitis and the nature of the adaptive immune response in murine models are yet to be elucidated. Adiponectin knock-out mice were orally administered dextran sulfate sodium for 7 days and were compared with wild-type mice. The severity of disease was analyzed histopathologically and through cytokine profiling...
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28258021/sartorius-muscle-flaps-perioperative-outcomes-based-on-surgical-specialty
#20
Tammam Obeid, Satinderjit Locham, Isibor Arhuidese, Besma Nejim, Hanaa D Aridi, Mahmoud Malas
OBJECTIVE: Complicated groin wounds often require repair by Sartorius Muscle Flap (SMF). Operating surgical specialty differs based on SMF indication, hospital, and operating surgeon preference. We aim to assess the effect of operating surgical specialty, indication for SMF, and other patient-level factors on 30-day outcomes. METHODS: We collected data on all patients undergoing SMF performed at our institution from 2005-2015, including age, sex, body mass index, comorbidity index (hypertension, diabetes, dyslipidemia, peripheral arterial disease, coronary artery disease), smoking status, history of malignancy, indication for SMF (infection, non-infectious complication, prophylaxis), and operating surgeon's specialty (vascular, plastic, general, other)...
February 28, 2017: Annals of Vascular Surgery
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