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Guillaume Riouallon, Christian Morin, Yann-Philippe Charles, Pierre Roussouly, Gaby Kreichati, Ibrahim Obeid, Stéphane Wolff
PURPOSE: The literature shows controversies concerning surgical treatment of Scheuermann's kyphosis between posterior-only fixation and combined anterior/posterior fusion. The aim of this study is to compare the clinical and radiological results and the rate of complications between these two techniques. METHODS: We performed a multicentric retrospective review of 131 patients who underwent primary fusion for Scheuermann's kyphosis divided into two groups: 67 patients operated via posterior approach only and 64 operated via combined anterior/posterior approach...
May 19, 2018: European Spine Journal
Sleiman Haddad, Susana Núñez-Pereira, Carlos Pigrau, Dolors Rodríguez-Pardo, Alba Vila-Casademunt, Ahmet Alanay, Emre R Acaroglu, Frank S Kleinstueck, Ibrahim Obeid, Francisco Javier Sanchez Perez-Grueso, Ferran Pellisé
PURPOSE: The impact of deep surgical site infection (SSI) on surgical outcomes after adult spinal deformity (ASD) surgery is still unclear. We aimed to study the morbidity of SSI in ASD and its impact on deformity correction and functional outcome. METHODS: Prospective multicenter matched-cohort study including consecutively enrolled ASD patients. Patients developing SSI were matched to similar controls in terms of age, gender, ASA, primary or revision, extent of fusion, and use of tri-columnar osteotomies...
May 4, 2018: European Spine Journal
Benjamin Newcomb, Cosima Rhein, Izolda Mileva, Rasheed Ahmad, Christopher J Clarke, Justin Snider, Lina M Obeid, Yusuf A Hannun
Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to produce the biologically active lipid ceramide. Previous studies have implicated ASM in the induction of the chemokine CCL5 in response to TNF-α, however, the lipid mediator of this effect was not established. In the present study, we identified a novel pathway connecting ASM and ceramide kinase (CERK). The results show that TNF-α induces the formation of ceramide 1-phosphate (C-1-P) in a CERK-dependent manner. Silencing of CERK blocks CCL5 production in response to TNF-α...
May 3, 2018: Journal of Lipid Research
Daniel Su, Anthony Obeid, Jason Hsu
No abstract text is available yet for this article.
April 26, 2018: Retina
R Patel, G Obeid
An osteochondroma, when reported in the maxillofacial region, is a benign neoplasm that involves the skull base, maxillary sinus, zygomatic arch, or mandible. Most commonly, the osteochondroma occurs in the coronoid process and the condyle. One rare subtype of osteochondroma reported in the literature, termed Jacob disease, arises from the coronoid process and interferes with the zygomatic arch. This report describes a unique case of an isolated osteochondroma arising from the zygomatic arch and interfering with the coronoid process, which was treated through surgical excision by an intraoral approach...
March 31, 2018: Journal of Oral and Maxillofacial Surgery
Hussain Mohamad Awwad, Carsten-Henning Ohlmann, Michael Stoeckle, Juergen Geisel, Rima Obeid
BACKGROUND: Folate is required for synthesis of methyl groups and DNA in growing cells. The association between folate and prostate cancer (PCa) is not conclusive. METHODS: We investigated concentrations of folate vitamers, S-adenosylhomocysteine (SAH) and S-adenosylmethionine (SAM) in blood of men with PCa (n = 129) or benign prostatic hyperplasia (BPH) (n = 73) who were recruited just after the first diagnosis. RESULTS: In younger subjects <65 years, concentrations of (6S)-5-CH3 -H4 folate (15...
April 16, 2018: Clinical Biochemistry
Stefan Pilz, Rima Obeid, Verena Schwetz, Christian Trummer, Marlene Pandis, Elisabeth Lerchbaum, Thomas R Pieber, Barbara Obermayer-Pietsch, Manfred Wilhelm, Andreas Hahn, Christiane Schön
Context: Hormonal contraceptive (HC) intake is associated with higher total 25-hydroxyvitamin D (25[OH]D) concentrations but the effect of HC on free 25(OH)D is unclear. Objective: We investigated whether free 25(OH)D concentrations differ according to use of HC. Design: This is a post-hoc analysis of a randomized open trial. Setting: This study was conducted from 13th January to 9th May 2016 at a clinical research organization in Esslingen, Germany...
April 16, 2018: Journal of Clinical Endocrinology and Metabolism
Orna Baron-Epel, Shiran Bord, Michal Cohen-Dar, Samira Obeid
BACKGROUND: Brucellosis is a contagious zoonotic disease transferred from sick animals to humans and endemic in the Middle East and other countries. Humans mainly acquire the disease by consuming non-pasteurized dairy products from infected animals. This study assesses the rates of non-pasteurized dairy product consumption, knowledge and attitudes regarding brucellosis among Israeli Arabs, in towns with and without reported cases of brucellosis. The aim is to assess if there is an association between knowledge, attitudes and consumption of non-pasteurized dairy products and if encountering the disease in the community is associated with consumption, attitudes and knowledge...
April 18, 2018: BMC Public Health
Nicolas Coant, Mónica García-Barros, Qifeng Zhang, Lina M Obeid, Yusuf A Hannun
Despite advances in the field, colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Research into bioactive sphingolipids over the past two decades has played an important role in increasing our understanding of the pathogenesis and therapeutics of CRC. In the complex metabolic network of sphingolipids, ceramidases (CDases) have a key function. These enzymes hydrolyze ceramides into sphingosine (SPH) which in turn is phosphorylated by sphingosine kinases (SK) 1 and 2 to generate sphingosine-1 phosphate (S1P)...
April 17, 2018: Oncogene
Jihad S Obeid, Laura M Beskow, Marie Rape, Ramkiran Gouripeddi, R Anthony Black, James J Cimino, Peter J Embi, Chunhua Weng, Rebecca Marnocha, John B Buse
Electronic health records (EHRs) provide great promise for identifying cohorts and enhancing research recruitment. Such approaches are sorely needed, but there are few descriptions in the literature of prevailing practices to guide their use. A multidisciplinary workgroup was formed to examine current practices in the use of EHRs in recruitment and to propose future directions. The group surveyed consortium members regarding current practices. Over 98% of the Clinical and Translational Science Award Consortium responded to the survey...
August 2017: Journal of Clinical and Translational Science
Stephanie J Weiss, Murtaza K Adam, Xinxiao Gao, Anthony Obeid, Arunan Sivalingam, Mitchell S Fineman, Joseph I Maguire, Sunir J Garg, Julia Haller, David H Fischer, Jason Hsu
PURPOSE: To examine rates of acute infectious endophthalmitis after pars plana vitrectomy (PPV) in eyes that received intraoperative subconjunctival antibiotics versus eyes that did not. METHODS: A retrospective, nonrandomized, comparative case series of 18,886 consecutive cases of transconjunctival 23-, 25-, and 27-gauge PPV over a 5-year period was performed. The impact of prophylactic intraoperative subconjunctival antibiotics on the development of acute infectious postoperative endophthalmitis was examined...
April 12, 2018: Retina
V Papadopoulou, P Germonpré, D Cosgrove, R J Eckersley, P A Dayton, G Obeid, A Boutros, M-X Tang, S Theunissen, C Balestra
PURPOSE: A reduction in ambient pressure or decompression from scuba diving can result in ultrasound-detectable venous gas emboli (VGE). These environmental exposures carry a risk of decompression sickness (DCS) which is mitigated by adherence to decompression schedules; however, bubbles are routinely observed for dives well within these limits and significant inter-personal variability in DCS risk exists. Here, we assess the variability and evolution of VGE for 2 h post-dive using echocardiography, following a standardized pool dive in calm warm conditions...
April 3, 2018: European Journal of Applied Physiology
Franco José Signorini, Virginia Polero, Germán Viscido, Luciano Navarro, Lucio Obeide, Federico Moser
BACKGROUND: Smoking cessation had been typically associated with weight gain. We have reported that there is no relationship between tobacco use and weight loss after bariatric surgery in the short term. The objective of this study was to establish the relationship between weight loss and the smoking habit in patients undergoing bariatric surgery and to analyze weight loss on severe smokers and on those patients who stopped smoking during the long-term postoperative period. METHODS: One hundred eighty-four patients included in our previous study were contacted by phone at 7 years after sleeve gastrectomy...
April 2, 2018: Obesity Surgery
Justin M Snider, Ashley J Snider, Lina M Obeid, Chiara Luberto, Yusuf A Hannun
Sphingolipids constitute a dynamic metabolic network that interconnects several bioactive molecules, including ceramide (Cer), sphingosine (Sph), sphingosine 1-phosphate (S1P), and ceramide 1-phosphate (C1P). The interconversion of these metabolites is controlled by a cohort of at least 40 enzymes, many of which respond to endogenous or exogenous stimuli. Typical probing of the sphingolipid pathway relies on sphingolipid mass levels or determination of the activity of individual enzymes. Either approach is unable to provide a complete analysis of flux through sphingolipid metabolism, which, given the interconnectivity of the sphingolipid pathway, is critical information to identify nodes of regulation...
April 2, 2018: Journal of Lipid Research
Anthony Obeid, Xinxiao Gao, Ferhina S Ali, Katherine E Talcott, Christopher M Aderman, Leslie Hyman, Allen C Ho, Jason Hsu
PURPOSE: Loss to follow-up (LTFU) may contribute to vision loss in patients with active proliferative diabetic retinopathy (PDR). The aim of this study is to determine and compare the rates of LTFU in patients with PDR receiving panretinal photocoagulation (PRP) or intravitreal injections (IVIs) with anti-vascular endothelial growth factor (VEGF) over approximately 4 years. Moreover, this study evaluates various risk factors for LTFU. DESIGN: Retrospective cohort study...
March 29, 2018: Ophthalmology
David Christopher Kieser, Derek Thomas Cawley, Cecile Roscop, Simon Mazas, Pierre Coudert, Louis Boissiere, Ibrahim Obeid, Jean-Marc Vital, Vincent Pointillart, Olivier Gille
PURPOSE: To understand whether a spondylolisthesis in the sub-axial spine cranial to a cervical disc arthroplasty (CDA) construes a risk of adjacent level disease (ALD). METHODS: A retrospective review of 164 patients with a minimum 5-year follow-up of a cervical disc arthroplasty was performed. Multi-level surgeries, including hybrid procedures, were included. Multiple implant types were included. The two inter-vertebral discs (IVD) cranial of the CDA were monitored for evidence of radiologic degeneration using the Kettler criteria...
March 31, 2018: European Spine Journal
Fadi Abou Obeid, Gardner Yost, Geetha Bhat, Erin Drever, Antone Tatooles
BACKGROUND: Vitamin D is an important hormone that regulates cardiac myocyte function. Low levels contribute to the development of cardiovascular disease and have been implicated in immune function and the inflammatory cascade. Patients who undergo left ventricular assist device (LVAD) implantation are at risk for driveline infection, stroke, and gastrointestinal (GI) bleeding. We investigated whether serum 25-hydroxy (25-OH) vitamin D levels affect clinical outcomes after LVAD. METHODS: 212 patients who underwent LVAD implantation between 2010 and 2015 were included...
March 30, 2018: Nutrition in Clinical Practice
Emily K Miller, Alba Vila-Casademunt, Brian J Neuman, Daniel M Sciubba, Khaled M Kebaish, Justin S Smith, Ahmet Alanay, Emre R Acaroglu, Frank Kleinstück, Ibrahim Obeid, Francisco Javier Sánchez Pérez-Grueso, Leah Y Carreon, Frank J Schwab, Shay Bess, Justin K Scheer, Virginie Lafage, Christopher I Shaffrey, Ferran Pellisé, Christopher P Ames
PURPOSE: To assess the ability of the recently developed adult spinal deformity frailty index (ASD-FI) to predict odds of perioperative complications, odds of reoperation, and length of hospital stay after adult spinal deformity (ASD) surgery using a database other than the one used to create the index. METHODS: We used the ASD-FI to calculate frailty scores for 266 ASD patients who had minimum postoperative follow-up of 2 years in the European Spine Study Group (ESSG) database...
March 30, 2018: European Spine Journal
Takashi Fujishiro, Louis Boissière, Derek Thomas Cawley, Daniel Larrieu, Olivier Gille, Jean-Marc Vital, Ferran Pellisé, Francisco Javier Sanchez Pérez-Grueso, Frank Kleinstück, Emre Acaroglu, Ahmet Alanay, Ibrahim Obeid
PURPOSE: We aimed to elucidate the factors for the decision-making process in the treatment of adult spinal deformity (ASD), including sagittal parameters, that impact health-related quality of life (HRQOL). METHODS: A multicenter prospective ASD database was retrospectively reviewed. The demographic data, HRQOL, and radiographic measures were analyzed using multivariate analyses in younger (≤ 50 years) and older (> 50 years) age groups. RESULTS: This study included 414 patients (134 surgical and 280 nonsurgical; mean age 30...
March 30, 2018: European Spine Journal
Elisabeth I Heath, Filipa Lynce, Joanne Xiu, Angela Ellerbrock, Sandeep K Reddy, Elias Obeid, Stephen V Liu, Aliccia Bollig-Fischer, Duska Separovic, Ari Vanderwalde
BACKGROUND/AIM: African Americans (AA) have the highest incidence and mortality of any racial/ethnic group in the US for most cancer types. Heterogeneity in the molecular biology of cancer, as a contributing factor to this disparity, is poorly understood. To address this gap in knowledge, we explored the molecular landscape of colorectal cancer (CRC), non-small cell lung cancer (NSCLC) and high-grade glioma (HGG) from 271 AA and 636 Caucasian (CC) cases. MATERIALS AND METHODS: DNA from formalin-fixed paraffin-embedded tumors was sequenced using next-generation sequencing...
April 2018: Anticancer Research
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