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Gynostemma

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https://www.readbyqxmd.com/read/28546827/chemical-constituents-from-a-gynostemma-laxum-and-their-antioxidant-and-neuroprotective-activities
#1
Ji Yeon Seo, Sang Kyum Kim, Phi Hung Nguyen, Ju Yong Lee, Pham Ha Thanh Tung, Sang Hyun Sung, Won Keun Oh
BACKGROUND: A few bioactivities of constituents from Gynostemma laxum, which has been collected in Vietnam, have been reported until now. There is no report about the effects of constituents from G. laxum although the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase-1 (HO-1) antioxidant defense system is involved in neuroprotection in the brain. Therefore, we investigated whether quercetin (2), benzoic acid (10) and their analogues (1, 3-9 and 11) from G. laxum have the antioxidant and neuroprotective activities and also their underlying mechanism...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28463530/cytotoxic-triterpenes-from-the-acid-hydrolyzate-of-gynostemma-pentaphyllum-saponins
#2
Lin Shi, De-Hong Tan, Ting-Cai Yan, Dong-Hua Jiang, Ming-Xiao Hou
One new dammarane-type triterpene, gypsapogenin A (1), was isolated from the acid hydrolyzate of total saponins from Gynostemma pentaphyllum (Thunb.) Makino, together with two known compounds, (20S,24S)-3β,20,21β,23β,25-pentahydroxy-21,24-cyclodammarane (2) and (23S)-3β-hydroxydammar-20,24-dien-21-oic acid 21,23-lactone (3). Its structural elucidations were accomplished mainly on the basis of the interpretation of spectroscopic data, such as IR, HR-TOF-MS, and NMR. The cytotoxic activities were evaluated against HepG2 and A549 human cancer cell lines...
May 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28422402/gypenoside-inhibits-interleukin-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritis-chondrocytes
#3
Zhi-Hong Wan, Qing Zhao
Gypenoside (GP), the main active ingredient of Gynostemma pentaphyllum, possesses a variety of pharmacological capacities including anti-inflammation, anti-oxidation, and anti-tumor. However, the effects of GP on IL-1β-stimulated human osteoarthritis (OA) chondrocytes are still unknown. Therefore, this study aimed to investigate the anti-inflammatory effects of GP on IL-1β-stimulated human OA chondrocytes and explore the possible mechanism. Our results showed that GP dose-dependently inhibited IL-1β-induced NO and PGE2 production in human OA chondrocytes...
April 19, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28258276/gypenosides-inhibits-xanthine-oxidoreductase-and-ameliorates-urate-excretion-in-hyperuricemic-rats-induced-by-high-cholesterol-and-high-fat-food-lipid-emulsion
#4
Minxia Pang, Yingying Fang, Suhong Chen, Xuexin Zhu, Chaowen Shan, Jie Su, Jingjing Yu, Bo Li, Yao Yang, Bo Chen, Kailun Liang, Huiming Hu, Guiyuan Lv
BACKGROUND The aim of this study was to study the effects of gypenosides (GPS) on lowering uric acid (UA) levels in hyperuricemic rats induced by lipid emulsion (LE) and the related mechanisms. GPS are natural saponins extracted from Gynostemma pentaphyllum. MATERIAL AND METHODS Forty-eight male SD rats were randomly divided into six groups: normal, model, two positive controls, and two GPS treated groups (two different doses of GPS). The normal group rats were fed a basic diet, and the other rats were orally pretreated with LE...
March 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28244718/apoe-and-cetp-taqib-polymorphisms-influence-metabolic-responses-to-hibiscus-sabdariffa-l-and-gynostemma-pentaphyllum-makino-tea-consumption-in-hypercholesterolemic-subjects
#5
Nutjaree Jeenduang, Boonnisa Sangkaew, Pacharee Chantaracha, Sirada Chanchareonsri, Thunyaluk Plyduang, Wanida Thitdee, Cathaleeya Samae, Wacharaporn Pitumanon
BACKGROUND AND OBJECTIVES: Hibiscus sabdariffa L. (HS) and Gynostemma pentaphyllum Makino (GP) have been used as traditional medicines to treat diabetes and hypercholesterolemia. Nevertheless, there is interindividual variation in the metabolic responses to HS and GP consumption. This may be due to genetic factors. The aim of this study was to investigate the effects of HS and GP tea consumption on anthropometric data, fasting blood glucose (FBG), and lipid concentrations in hypercholesterolemia subjects with different genotypes of the APOE and CETP TaqIB polymorphisms...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28005447/gynostemma-pentaphyllum-ethanolic-extract-protects-against-memory-deficits-in-an-mptp-lesioned-mouse-model-of-parkinson-s-disease-treated-with-l-dopa
#6
Kyung Sook Kim, Ting Ting Zhao, Keon Sung Shin, Hyun Jin Park, Yoon Jeong Cho, Kyung Eun Lee, Seung Hwan Kim, Myung Koo Lee
This study investigated the effects of ethanol extract from Gynostemma pentaphyllum (GP-EX) on memory deficits in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD) (MPTP-lesioned mice). MPTP (30 mg/kg/day, 5 days)-lesioned mice showed deficits of habit learning memory and spatial memory, which were further aggravated by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA) (25 mg/kg, 21 days). However, treatment with GP-EX (50 mg/kg, 21 days) ameliorated memory deficits in MPTP-lesioned mice treated with L-DOPA (25 mg/kg): GP-EX prevented the decreases in retention latency time in the passive avoidance test and tyrosine hydroxylase-immunopositive cells and dopamine levels in the nigrostriatum...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27993866/separation-and-purification-of-ombuoside-from-gynostemma-pentaphyllum-by-microwave-assisted-extraction-coupled-with-high-speed-counter-current-chromatography
#7
Wenhui Jiang, Hu Shan, Jiying Song, Haitao Lü
A rapid and efficient method for the separation and purification of ombuoside from Gynostemma pentaphyllum by microwave-assisted extraction coupled with high-speed counter-current chromatography (HSCCC) was successfully developed. Using an orthogonal array design L9 (3(4)), the extraction conditions, including microwave power, irradiation time, solid-to-liquid ratio and extraction times, were optimized. Ombuoside was isolated and purified from the crude extraction by HSCCC with two-phase solvent system composed of n-hexane:ethyl acetate:ethanol:water (5:6:5:5, v/v) in a single run...
January 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27976232/establishing-compositional-guidelines-for-flavonoids-and-saponins-in-gynostemma-pentaphyllum
#8
D Leach, I Ahmed, J De Voss, H Wohlmuth
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27872647/antimalarial-properties-of-aqueous-crude-extracts-of-gynostemma-pentaphyllum-and-moringa-oleifera-leaves-in-combination-with-artesunate-in-plasmodium-berghei-infected-mice
#9
Voravuth Somsak, Preeyanuch Borkaew, Chokdee Klubsri, Kittiyaporn Dondee, Panatda Bootprom, Butsarat Saiphet
Due to the emergence and spread of malaria parasite with resistance to antimalarial drugs, discovery and development of new, safe, and affordable antimalarial are urgently needed. In this respect, medicinal plant extracts are targets to optimize antimalarial actions and restore efficacy of standard antimalarial drugs. The present study was aimed at determining the antimalarial activities of Gynostemma pentaphyllum and Moringa oleifera leaf extracts in combination with artesunate against Plasmodium berghei-infected mice...
2016: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27859537/development-of-a-targeted-method-for-quantification-of-gypenoside-xlix-in-rat-plasma-using-spe-and-lc-ms-ms
#10
Song Guo, Chengxu Sui, Ying Ma
A sensitive, selective and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of gypenoside XLIX, a naturally occurring gypenoside of Gynostemma pentaphyllum in rat plasma and then validated according to the US Food and Drug Administration's Guidance for Industry: Bioanalytical Method Validation. Plasma samples were prepared by a simple solid-phase extraction. Separation was performed on a Waters XBridgeTM BEH C18 chromatography column (4.6 × 50 mm, 2...
November 16, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27744265/molecular-characterization-expression-and-regulation-of-gynostemma-pentaphyllum-squalene-epoxidase-gene-1
#11
Huihong Guo, Rufang Li, Shibiao Liu, Na Zhao, Shuo Han, Mengmeng Lu, Xiaomin Liu, Xinli Xia
Gynostemma pentaphyllum (Thunb.) Makino is a perennial medicinal herb widely distributed in China. This herb contains important medicinal components called gypenosides, which belong to dammarane-type triterpenoid saponins. Squalene epoxidase (SE, EC 1.14.99.7) catalyzes the epoxidation of squalene to form oxidosqualene and is a key regulatory enzyme in triterpenoid saponin biosynthesis. In this study, a SE gene designated as GpSE1 was isolated from G. pentaphyllum leaves. The deduced protein sequence of GpSE1 contained two conserved domains involved in the catalytic function of SE...
December 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27708693/anti-cancer-effects-of-gynostemma-pentaphyllum-thunb-makino-jiaogulan
#12
Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie, Wenzhe Ma
Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. In this review, we have summarized recent research progress on the anti-cancer activities and mechanisms of action of GpM, as well as determining the material basis for the anti-cancer effects of GpM by searching the PubMed, Web of Science and China National Knowledge Infrastructure databases...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27569782/characteristics-composition-and-antioxidant-activities-in-vitro-and-in-vivo-of-gynostemma-pentaphyllum-thunb-makino-seed-oil
#13
Lu Wang, Min Pang, Xiaobing Wang, Pan Wang, Yaping Xiao, Quanhong Liu
BACKGROUND: In order to further develop and utilise Gynostemma pentaphyllum (Thunb.) Makino seeds, a detailed analysis of the characteristics of G. pentaphyllum seed oil (GPSO), including its physico-chemical parameters, fatty acid composition and unsaponifiable matter constituents, has been investigated in this study. The antioxidant potential of GPSO was evaluated by radical-scavenging activity and ferric-reducing antioxidant power assay in vitro, and the antioxidant activity in vivo was examined by using an aged mice model...
May 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27548135/immunomodulatory-and-antioxidant-effects-of-polysaccharides-from-gynostemma-pentaphyllum-makino-in-immunosuppressed-mice
#14
Xiaoya Shang, Yu Chao, Yuan Zhang, Chengyuan Lu, Chunlan Xu, Weining Niu
The immunomodulatory and antioxidant activities of crude polysaccharides extracted from Gynostemma pentaphyllum Makino (GPMPP) were investigated. GPMPP was composed of rhamnose, arabinose, xylose, mannose, glucose and galactose in the molar ratio of 1.39:3.76:1.00:1.64:4.98:5.88. In vivo studies showed GPMPP significantly increased the spleen and thymus indices, activated the macrophage phagocytosis and NK cells, and exhibited activity on none or Con A/LPS-stimulated splenocytes in a dose-dependent manner in C57BL/6 mice...
August 19, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27384065/flavonol-glycosides-from-the-aerial-parts-of-gynostemma-pentaphyllum-and-their-antioxidant-activity
#15
Hari Jang, Jin Woo Lee, Chul Lee, Qinghao Jin, Myung Koo Lee, Chong Kil Lee, Mi Kyeong Lee, Bang Yeon Hwang
The phytochemical investigation of the aerial parts of Gynostemma pentaphyllum led to the isolation of a new flavonol glycoside, gynopentaphylloside (1), along with seven known compounds (2-8). The structure of the new compound was determined on the basis of 1D, 2D NMR and HRESIMS data as well as acid hydrolysis. The antioxidant activity of the isolates was evaluated by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay.
September 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27329722/gypenoside-l-inhibits-autophagic-flux-and-induces-cell-death-in-human-esophageal-cancer-cells-through-endoplasm-reticulum-stress-mediated-ca2-release
#16
Chenghui Liao, Kai Zheng, Yan Li, Hong Xu, Qiangrong Kang, Long Fan, Xiaopeng Hu, Zhe Jin, Yong Zeng, Xiaoli Kong, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Yifei Wang, Zhendan He
Esophageal cancer is one of the leading cause of cancer mortality in the world. Due to the increased drug and radiation tolerance, it is urgent to develop novel anticancer agent that triggers nonapoptotic cell death to compensate for apoptosis resistance. In this study, we show that treatment with gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, induced nonapoptotic, lysosome-associated cell death in human esophageal cancer cells. Gyp-L-induced cell death was associated with lysosomal swelling and autophagic flux inhibition...
July 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27322831/gypenoside-protects-against-myocardial-ischemia-reperfusion-injury-by-inhibiting-cardiomyocytes-apoptosis-via-inhibition-of-chop-pathway-and-activation-of-pi3k-akt-pathway-in-vivo-and-in-vitro
#17
Haijie Yu, Haishan Zhang, Weihua Zhao, Liang Guo, Xueyuan Li, Yang Li, Xingang Zhang, Yingxian Sun
BACKGROUND/AIMS: Ischemia-reperfusion (I/R) injury is believed to be the major cause for detriments in coronary heart diseases, but few effective therapies for prevention or treatment of I/R injury are available. Gypenoside (GP) is the predominant effective component of Gynostemma pentaphyllum and possesses capacities against inflammation and oxidation. In the present study, the role of GP in ameliorating myocardial I/R injury was investigated. METHODS: effect GP on the cardiac structure of I/R injured rats was assessed by H&E and TTC staining...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27313532/gypenoside-protects-cardiomyocytes-against-ischemia-reperfusion-injury-via-the-inhibition-of-mitogen-activated-protein-kinase-mediated-nuclear-factor-kappa-b-pathway-in-vitro-and-in-vivo
#18
Haijie Yu, Liye Shi, Guoxian Qi, Shijie Zhao, Yuan Gao, Yuzhe Li
Gypenoside (GP) is the major effective component of Gynostemma pentaphyllum and has been shown to encompass a variety of pharmacological activities. In this study, we investigated whether GP is able to protect cardiomyocytes against injury myocardial ischemia-reperfusion (I/R) injury by using in vitro oxygen-glucose deprivation-reoxygenation (OGD/R) H9c2 cell model and in vivo myocardial I/R rat model. We found that GP pre-treatment alleviated the impairments on the cardiac structure and function in I/R injured rats...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27213058/gypenoside-attenuates-%C3%AE-amyloid-induced-inflammation-in-n9-microglial-cells-via-socs1-signaling
#19
Hui Cai, Qianlei Liang, Guanqun Ge
Reducing β amyloid- (Aβ-) induced microglial activation is believed to be effective in treating Alzheimer's disease (AD). Microglia can be activated into classic activated state (M1 state) or alternative activated state (M2 state), and the former is harmful; in contrast, the latter is beneficial. Gypenoside (GP) is the major bioactive constituent of Gynostemma pentaphyllum, a traditional Chinese herb medicine. In this study, we hypothesized that GP attenuates Aβ-induced microglial activation by ameliorating microglial M1/M2 states, and the process may be mediated by suppressor of cell signaling protein 1 (SOCS1)...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27121311/triterpenoid-herbal-saponins-enhance-beneficial-bacteria-decrease-sulfate-reducing-bacteria-modulate-inflammatory-intestinal-microenvironment-and-exert-cancer-preventive-effects-in-apcmin-mice
#20
Lei Chen, Manreetpal S Brar, Frederick C C Leung, W L Wendy Hsiao
Saponins derived from medicinal plants have raised considerable interest for their preventive roles in various diseases. Here, we investigated the impacts of triterpenoid saponins isolated from Gynostemma pentaphyllum (GpS) on gut microbiome, mucosal environment, and the preventive effect on tumor growth. Six-week old ApcMin/+ mice and their wild-type littermates were fed either with vehicle or GpS daily for the duration of 8 weeks. The fecal microbiome was analyzed by enterobacterial repetitive intergenic consensus (ERIC)-PCR and 16S rRNA gene pyrosequencing...
May 24, 2016: Oncotarget
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