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Gynostemma

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https://www.readbyqxmd.com/read/28985570/triterpenes-derived-from-hydrolyzate-of-total-gynostemma-pentaphyllum-saponins-with-anti-hepatic-fibrosis-and-protective-activity-against-h2o2-induced-injury
#1
Xiaoshu Zhang, Guohui Shi, Yuanyuan Sun, Xiaojun Wu, Yuqing Zhao
Gynostemma pentaphyllum is a popular functional food, and it is also used as a traditional medicine in Asia. In this study, five previously undescribed triterpenes, gypensapogenin M, gypensapogenin N, gypensapogenin O, gypensapogenin P, and gypensapogenin Q, together with five known compounds were isolated from the hydrolyzate of total G. pentaphyllum saponins. The bioassay data showed that all the triterpenes exhibited significant protective activity against H2O2-induced myocardial cell injury and anti-hepatic fibrosis activity...
October 3, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28962182/gypenosides-induce-cell-death-and-alter-gene-expression-in-human-oral-cancer-hsc-3-cells
#2
Kung-Wen Lu, Yi-Shih Ma, Fu-Shun Yu, Yi-Ping Huang, Yung-Lin Chu, Rick Sai-Chuen Wu, Ching-Lung Liao, Fu-Shin Chueh, Jing-Gung Chung
Gypenosides (Gyp), the primary components of Gynostemma pentaphyllum Makino, have long been used as a Chinese herbal medicine. In the present study, the effects of Gyp on cell viability, the cell cycle, cell apoptosis, DNA damage and chromatin condensation were investigated in vitro using human oral cancer HSC-3 cells. The results of the present study indicated that Gyp induces cell death, G2/M phase arrest and apoptosis in HSC-3 cells in a dose-dependent manner. It was also demonstrated that Gyp decreased the depolarization of mitochondrial membrane potential in a time-dependent manner...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28955369/completion-of-eight-gynostemma-bl-cucurbitaceae-chloroplast-genomes-characterization-comparative-analysis-and-phylogenetic-relationships
#3
Xiao Zhang, Tao Zhou, Nazish Kanwal, Yuemei Zhao, Guoqing Bai, Guifang Zhao
Gynostemma BL., belonging to the family Cucurbitaceae, is a genus containing 17 creeping herbaceous species mainly distributed in East Asia. It can be divided into two subgenera based on different fruit morphology. Herein, we report eight complete chloroplast genome sequences of the genus Gynostemma, which were obtained by Illumina paired-end sequencing, assembly, and annotation. The length of the eight complete cp genomes ranged from 157,576 bp (G. pentaphyllum) to 158,273 bp (G. laxiflorum). Each encoded 133 genes, including 87 protein-coding genes, 37 tRNA genes, eight rRNA genes, and one pseudogene...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28839375/preparation-and-bioactivity-of-exopolysaccharide-from-an-endophytic-fungus-chaetomium-sp-of-the-medicinal-plant-gynostemma-pentaphylla
#4
Huiru Zhang, Xueqin Wang, Ruifang Li, Xincheng Sun, Siwen Sun, Qiang Li, Chunping Xu
BACKGROUND: Many exopolysaccharides from the endophytes in medicinal plants possess various potential bioactivities. MATERIALS AND METHODS: The endophytic fungus JY25 was isolated from the leave of the Chinese medicinal plant Gynostemma pentaphylla and identified as Chaetomium sp. by its phylogenetic and physiological analysis. One exopolysaccharide (EPS) fraction was isolated from the fermentation broth by ethanol precipitation and purified by gel filtration chromatography on Sepharose CL-6B...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28697598/nox2-mediated-tfeb-activation-and-vacuolization-regulate-lysosome-associated-cell-death-induced-by-gypenoside-l-a-saponin-isolated-from-gynostemma-pentaphyllum
#5
Kai Zheng, Yingchun Jiang, Chenghui Liao, Xiaopeng Hu, Yan Li, Yong Zeng, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Yifei Wang, Zhendan He
Downregulation of apoptotic signal pathway and activation of protective autophagy mainly contribute to the chemoresistance of tumor cells. Therefore, exploring efficient chemotherapeutic agents or isolating novel natural products that can trigger nonapoptotic and nonautophagic cell death such as lysosome-associated death is emergently required. We have recently extracted a saponin, gypenoside L (Gyp-L), from Gynostemma pentaphyllum and showed that Gyp-L was able to induce nonapoptotic cell death of esophageal cancer cells associated with lysosome swelling...
August 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28662582/further-new-gypenosides-from-jiaogulan-gynostemma-pentaphyllum
#6
Jun Wang, Jun-Li Yang, Pan-Pan Zhou, Xian-Hua Meng, Yan-Ping Shi
Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries. In this study, six new gypenosides (1-6) were isolated from the aerial parts of G. pentaphyllum. Their molecular structures were elucidated through spectroscopic analysis and acid hydrolysis. Gypenosides 1 and 2 represented the first example of a dammar-21-O- glucopyranoside without any unsaturated functional group and a dammar-3-O-glucopyranosyl-25-O-glucopyranoside without any cyclization in the side chain, respectively...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28659031/gypenosides-ameliorate-carbon-tetrachloride-induced-liver-fibrosis-by-inhibiting-the-differentiation-of-hepatic-progenitor-cells-into-myofibroblasts
#7
Jiamei Chen, Xuewei Li, Yonghong Hu, Wei Liu, Qun Zhou, Hua Zhang, Yongping Mu, Ping Liu
Gypenosides (GPs), the predominant components of Gynostemma pentaphyllum, exert antifibrotic effects; however, the mechanisms underlying their ability to ameliorate liver fibrosis are unclear. Liver fibrosis was induced in C57BL/6 mice via subcutaneous injection of 10% carbon tetrachloride (CCl[Formula: see text] three times a week for two weeks. Then, CCl4 was administered in conjunction with intragastric GPs for another three weeks. For in vitro analyses, WB-F344, hepatatic progenitor cells (HPCs) were treated with transforming growth factor beta 1 (TGF-[Formula: see text]1) with or without GPs for 48[Formula: see text]h...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28546827/chemical-constituents-from-a-gynostemma-laxum-and-their-antioxidant-and-neuroprotective-activities
#8
Ji Yeon Seo, Sang Kyum Kim, Phi Hung Nguyen, Ju Yong Lee, Pham Ha Thanh Tung, Sang Hyun Sung, Won Keun Oh
BACKGROUND: A few bioactivities of constituents from Gynostemma laxum, which has been collected in Vietnam, have been reported until now. There is no report about the effects of constituents from G. laxum although the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase-1 (HO-1) antioxidant defense system is involved in neuroprotection in the brain. Therefore, we investigated whether quercetin (2), benzoic acid (10) and their analogues (1, 3-9 and 11) from G. laxum have the antioxidant and neuroprotective activities and also their underlying mechanism...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28463530/cytotoxic-triterpenes-from-the-acid-hydrolyzate-of-gynostemma-pentaphyllum-saponins
#9
Lin Shi, De-Hong Tan, Ting-Cai Yan, Dong-Hua Jiang, Ming-Xiao Hou
One new dammarane-type triterpene, gypsapogenin A (1), was isolated from the acid hydrolyzate of total saponins from Gynostemma pentaphyllum (Thunb.) Makino, together with two known compounds, (20S,24S)-3β,20,21β,23β,25-pentahydroxy-21,24-cyclodammarane (2) and (23S)-3β-hydroxydammar-20,24-dien-21-oic acid 21,23-lactone (3). Its structural elucidations were accomplished mainly on the basis of the interpretation of spectroscopic data, such as IR, HR-TOF-MS, and NMR. The cytotoxic activities were evaluated against HepG2 and A549 human cancer cell lines...
May 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28422402/gypenoside-inhibits-interleukin-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritis-chondrocytes
#10
Zhi-Hong Wan, Qing Zhao
Gypenoside (GP), the main active ingredient of Gynostemma pentaphyllum, possesses a variety of pharmacological capacities including anti-inflammation, anti-oxidation, and anti-tumor. However, the effects of GP on IL-1β-stimulated human osteoarthritis (OA) chondrocytes are still unknown. Therefore, this study aimed to investigate the anti-inflammatory effects of GP on IL-1β-stimulated human OA chondrocytes and explore the possible mechanism. Our results showed that GP dose-dependently inhibited IL-1β-induced NO and PGE2 production in human OA chondrocytes...
April 19, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28258276/gypenosides-inhibits-xanthine-oxidoreductase-and-ameliorates-urate-excretion-in-hyperuricemic-rats-induced-by-high-cholesterol-and-high-fat-food-lipid-emulsion
#11
Minxia Pang, Yingying Fang, Suhong Chen, Xuexin Zhu, Chaowen Shan, Jie Su, Jingjing Yu, Bo Li, Yao Yang, Bo Chen, Kailun Liang, Huiming Hu, Guiyuan Lv
BACKGROUND The aim of this study was to study the effects of gypenosides (GPS) on lowering uric acid (UA) levels in hyperuricemic rats induced by lipid emulsion (LE) and the related mechanisms. GPS are natural saponins extracted from Gynostemma pentaphyllum. MATERIAL AND METHODS Forty-eight male SD rats were randomly divided into six groups: normal, model, two positive controls, and two GPS treated groups (two different doses of GPS). The normal group rats were fed a basic diet, and the other rats were orally pretreated with LE...
March 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28244718/apoe-and-cetp-taqib-polymorphisms-influence-metabolic-responses-to-hibiscus-sabdariffa-l-and-gynostemma-pentaphyllum-makino-tea-consumption-in-hypercholesterolemic-subjects
#12
RANDOMIZED CONTROLLED TRIAL
Nutjaree Jeenduang, Boonnisa Sangkaew, Pacharee Chantaracha, Sirada Chanchareonsri, Thunyaluk Plyduang, Wanida Thitdee, Cathaleeya Samae, Wacharaporn Pitumanon
BACKGROUND AND OBJECTIVES: Hibiscus sabdariffa L. (HS) and Gynostemma pentaphyllum Makino (GP) have been used as traditional medicines to treat diabetes and hypercholesterolemia. Nevertheless, there is interindividual variation in the metabolic responses to HS and GP consumption. This may be due to genetic factors. The aim of this study was to investigate the effects of HS and GP tea consumption on anthropometric data, fasting blood glucose (FBG), and lipid concentrations in hypercholesterolemia subjects with different genotypes of the APOE and CETP TaqIB polymorphisms...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28005447/gynostemma-pentaphyllum-ethanolic-extract-protects-against-memory-deficits-in-an-mptp-lesioned-mouse-model-of-parkinson-s-disease-treated-with-l-dopa
#13
Kyung Sook Kim, Ting Ting Zhao, Keon Sung Shin, Hyun Jin Park, Yoon Jeong Cho, Kyung Eun Lee, Seung Hwan Kim, Myung Koo Lee
This study investigated the effects of ethanol extract from Gynostemma pentaphyllum (GP-EX) on memory deficits in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD) (MPTP-lesioned mice). MPTP (30 mg/kg/day, 5 days)-lesioned mice showed deficits of habit learning memory and spatial memory, which were further aggravated by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA) (25 mg/kg, 21 days). However, treatment with GP-EX (50 mg/kg, 21 days) ameliorated memory deficits in MPTP-lesioned mice treated with L-DOPA (25 mg/kg): GP-EX prevented the decreases in retention latency time in the passive avoidance test and tyrosine hydroxylase-immunopositive cells and dopamine levels in the nigrostriatum...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27993866/separation-and-purification-of-ombuoside-from-gynostemma-pentaphyllum-by-microwave-assisted-extraction-coupled-with-high-speed-counter-current-chromatography
#14
Wenhui Jiang, Hu Shan, Jiying Song, Haitao Lü
A rapid and efficient method for the separation and purification of ombuoside from Gynostemma pentaphyllum by microwave-assisted extraction coupled with high-speed counter-current chromatography (HSCCC) was successfully developed. Using an orthogonal array design L9 (3(4)), the extraction conditions, including microwave power, irradiation time, solid-to-liquid ratio and extraction times, were optimized. Ombuoside was isolated and purified from the crude extraction by HSCCC with two-phase solvent system composed of n-hexane:ethyl acetate:ethanol:water (5:6:5:5, v/v) in a single run...
January 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27976232/establishing-compositional-guidelines-for-flavonoids-and-saponins-in-gynostemma-pentaphyllum
#15
D Leach, I Ahmed, J De Voss, H Wohlmuth
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27872647/antimalarial-properties-of-aqueous-crude-extracts-of-gynostemma-pentaphyllum-and-moringa-oleifera-leaves-in-combination-with-artesunate-in-plasmodium-berghei-infected-mice
#16
Voravuth Somsak, Preeyanuch Borkaew, Chokdee Klubsri, Kittiyaporn Dondee, Panatda Bootprom, Butsarat Saiphet
Due to the emergence and spread of malaria parasite with resistance to antimalarial drugs, discovery and development of new, safe, and affordable antimalarial are urgently needed. In this respect, medicinal plant extracts are targets to optimize antimalarial actions and restore efficacy of standard antimalarial drugs. The present study was aimed at determining the antimalarial activities of Gynostemma pentaphyllum and Moringa oleifera leaf extracts in combination with artesunate against Plasmodium berghei-infected mice...
2016: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27859537/development-of-a-targeted-method-for-quantification-of-gypenoside-xlix-in-rat-plasma-using-spe-and-lc-ms-ms
#17
Song Guo, Chengxu Sui, Ying Ma
A sensitive, selective and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of gypenoside XLIX, a naturally occurring gypenoside of Gynostemma pentaphyllum in rat plasma and then validated according to the US Food and Drug Administration's Guidance for Industry: Bioanalytical Method Validation. Plasma samples were prepared by a simple solid-phase extraction. Separation was performed on a Waters XBridgeTM BEH C18 chromatography column (4.6 × 50 mm, 2...
June 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27744265/molecular-characterization-expression-and-regulation-of-gynostemma-pentaphyllum-squalene-epoxidase-gene-1
#18
Huihong Guo, Rufang Li, Shibiao Liu, Na Zhao, Shuo Han, Mengmeng Lu, Xiaomin Liu, Xinli Xia
Gynostemma pentaphyllum (Thunb.) Makino is a perennial medicinal herb widely distributed in China. This herb contains important medicinal components called gypenosides, which belong to dammarane-type triterpenoid saponins. Squalene epoxidase (SE, EC 1.14.99.7) catalyzes the epoxidation of squalene to form oxidosqualene and is a key regulatory enzyme in triterpenoid saponin biosynthesis. In this study, a SE gene designated as GpSE1 was isolated from G. pentaphyllum leaves. The deduced protein sequence of GpSE1 contained two conserved domains involved in the catalytic function of SE...
December 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27708693/anti-cancer-effects-of-gynostemma-pentaphyllum-thunb-makino-jiaogulan
#19
REVIEW
Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie, Wenzhe Ma
Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. In this review, we have summarized recent research progress on the anti-cancer activities and mechanisms of action of GpM, as well as determining the material basis for the anti-cancer effects of GpM by searching the PubMed, Web of Science and China National Knowledge Infrastructure databases...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27569782/characteristics-composition-and-antioxidant-activities-in-vitro-and-in-vivo-of-gynostemma-pentaphyllum-thunb-makino-seed-oil
#20
Lu Wang, Min Pang, Xiaobing Wang, Pan Wang, Yaping Xiao, Quanhong Liu
BACKGROUND: In order to further develop and utilise Gynostemma pentaphyllum (Thunb.) Makino seeds, a detailed analysis of the characteristics of G. pentaphyllum seed oil (GPSO), including its physico-chemical parameters, fatty acid composition and unsaponifiable matter constituents, has been investigated in this study. The antioxidant potential of GPSO was evaluated by radical-scavenging activity and ferric-reducing antioxidant power assay in vitro, and the antioxidant activity in vivo was examined by using an aged mice model...
May 2017: Journal of the Science of Food and Agriculture
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