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JOURNAL ARTICLE
Sen-Jie Zhong, Xin-Yuan Zhao, Xiang Gao, Ru-Yin Huang, Jie Chen, Hui Wu, Hong-Cheng Fang, Shao-Xiang Xian
The clinical data of coronary heart disease(CHD) patients treated in the First Affiliated Hospital of Guangzhou University of Chinese Medicine and Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to March 2023 were retrospectively collected. This study involved the descriptive analysis of demographic characteristics, clinical symptoms, and tongue and pulse features. The χ~2 test was conducted to analyze the distribution of syndrome elements and their combinations at diffe-rent stages of CHD, so as to reveal the clinical characteristics and syndrome patterns at various pathological stages of CHD...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#22
JOURNAL ARTICLE
Jinxia Liu, Jane MacNaughtan, Annarein J C Kerbert, Theo Portlock, Javier Martínez Gonzalez, Yi Jin, Frederick Clasen, Abeba Habtesion, Huoyan Ji, Qin Jin, Alexandra Phillips, Francesco De Chiara, Ganesh Ingavle, Cesar Jimenez, Giacomo Zaccherini, Katherine Husi, Miguel Angel Rodriguez Gandia, Paul Cordero, Junpei Soeda, Lynda McConaghy, Jude Oben, Karen Church, Jia V Li, Haifeng Wu, Aarti Jalan, Pere Gines, Elsa Solà, Simon Eaton, Carrie Morgan, Michal Kowalski, Daniel Green, Amir Gander, Lindsey A Edwards, I Jane Cox, Helena Cortez-Pinto, Thomas Avery, Reiner Wiest, Francois Durand, Paolo Caraceni, Roberto Elosua, Joan Vila, Marco Pavesi, Vicente Arroyo, Nathan Davies, Rajeshwar P Mookerjee, Victor Vargas, Susan Sandeman, Gautam Mehta, Saeed Shoaie, Julian Marchesi, Agustín Albillos, Fausto Andreola, Rajiv Jalan
OBJECTIVE: Targeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, Yaq-001 in models of cirrhosis and acute-on-chronic liver failure (ACLF) and, its safety and tolerability in a clinical trial in cirrhosis. DESIGN: Performance of Yaq-001 was evaluated in vitro . Two-rat models of cirrhosis and ACLF, (4 weeks, bile duct ligation with or without lipopolysaccharide), receiving Yaq-001 for 2 weeks; and two-mouse models of cirrhosis (6-week and 12-week carbon tetrachloride (CCl4)) receiving Yaq-001 for 6 weeks were studied...
April 15, 2024: Gut
#23
JOURNAL ARTICLE
Velázquez-Orozco Verónica, Nicolás-Toledo Leticia, Dávila-Santacruz Saret, Corona-Quintanilla Dora Luz, Cuevas Estela, Martínez-Gómez Margarita, Ortega-Soto Arturo, Castelán Francisco, Rodríguez-Antolín Jorge
High sugar-sweetened beverage intake has been related to kidney disease and metabolic alterations in humans. We determine the impact of high sucrose intake from pregnancy until early postnatal days, and during postweaning on kidneys from adult male offspring rats. Wistar female rats were mated and assigned into two groups: one control drinking tap water (CM) and another drinking 5% sucrose diluted in water (SM). At weaning, two offspring per mother were randomly allocated into two experimental groups, one of them had free access to simple water (CO) and the other to 5% sucrose (SO) for 14 weeks...
April 13, 2024: Physiology & Behavior
#24
JOURNAL ARTICLE
Dong-Yue Ma, Hao Wang, Jun Guo, Fu Wang
Benign Prostatic Hyperplasia, as a common disease in the male urinary system, has traditionally been considered to have the basic pathogenesis of kidney deficiency and blood stasis. However, this disease involves many pathological factors such as "damp-heat", leading to confusion and difficulty in resolving the condition. "Fen Xiao Zou Xie" is an important treatment method used by Ye Tianshi to address damp-heat patterns and is now widely applied in the diagnosis and treatment of urinary system diseases. "Fen Xiao" refers to the removal of pathogenic factors through different pathways, while "Zou Xie" means using medications that promote excretion and do not stay, allowing the elimination of pathogenic factors from the body...
July 2023: Zhonghua Nan Ke Xue, National Journal of Andrology
#25
JOURNAL ARTICLE
Xiaowei Dong, Jinmin Zhang
Oral delivery of chemotherapy drugs is the most favorable and preferred route of drug administration. However, because of poor solubility and/or permeability, most chemotherapy drugs are given by intravenous administration. Docetaxel (DTX) is a potent chemotherapy drug that inhibits microtubular depolymerization and is widely used to treat numerous cancers. DTX is highly lipophilic and insoluble in water; thus, 50% polysorbate 80, which may cause hypersensitivity reactions and reduce drug uptake by tumor tissue, is used in the commercial DTX injection to dissolve DTX...
June 2024: Toxicology Reports
#26
JOURNAL ARTICLE
Yuan-Chi Huang, Chan-Jung Liu, Ze-Hong Lu, Ho-Shiang Huang
Excessive sodium intake is associated with nephrolithiasis, but the impact of sodium-deficient (SD) diets is unknown. Hence, we investigated the effects of short- and long-term SD diets on the expression of renal aquaporins and sodium transporters, and thus calcium oxalate (CaOx) crystal formation in hyperoxaluria rats. In a short-term sodium balance study, six male rats received drinking water and six received 0.75% ethylene glycol (EG) to induce hyperoxaluria. After a 30-day period of feeding on normal chow, both groups were treated with a normal-sodium diet for 5 days, followed by a sodium-free diet for the next 5 days...
April 1, 2024: International Journal of Molecular Sciences
#27
JOURNAL ARTICLE
Raissa Munderere, Muhammad Gulfam, Israr Ali, Seon-Hwa Kim, Trung Thang Vu, Sang-Hyug Park, Kwon Taek Lim
Methotrexate (MTX) has poor water solubility and low bioavailability, and cancer cells can become resistant to it, which limits its safe delivery to tumor sites and reduces its clinical efficacy. Herein, we developed novel redox-responsive hybrid nanoparticles (NPs) from hyaluronic acid (HA) and 3-mercaptopropionic acid (MPA)-coated gold NPs (gold@MPA NPs), which were further conjugated with folic acid (FA). The design of FA-HA-ss-gold NPs aimed at enhancing cellular uptake specifically in cancer cells using an active FA/HA dual targeting strategy for enhanced tumor eradication...
March 31, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#28
JOURNAL ARTICLE
Kyle C White, Ary Serpa-Neto, Rod Hurford, Pierre Clement, Kevin B Laupland, Marlies Ostermann, Barnaby Sanderson, Michelle Gatton, Rinaldo Bellomo
PURPOSE: A positive fluid balance (FB) is associated with harm in intensive care unit (ICU) patients with acute kidney injury (AKI). We aimed to understand how a positive balance develops in such patients. METHODS: Multinational, retrospective cohort study of critically ill patients with AKI not requiring renal replacement therapy. RESULTS: AKI occurred at a median of two days after admission in 7894 (17.3%) patients. Cumulative FB became progressively positive, peaking on day three despite only 848 (10...
April 11, 2024: Journal of Critical Care
#29
JOURNAL ARTICLE
Yake Luo, Shanshan Ma, Jianxun Zhang, Qidong Zhang, Yanhao Zhang, Jian Mao, Hang Yuan, Gangfeng Ouyang, Shusheng Zhang, Wuduo Zhao
Matrix deposition plays a critical role in image quality of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). To improve the ionization efficiency and overcome the limitation of traditional matrix deposition methods in the face of difficult-to-sublimate or difficult-to-dissolve matrix, covalent organic frameworks (COFs) named COF-DhaTab was successfully synthesized and firstly used as matrix film. It was fabricated by imprinting of sieved COF-DhaTab powder on the surface of a double-sided adhesive tape...
May 15, 2024: Analytica Chimica Acta
#30
JOURNAL ARTICLE
Brian Wowk, John Phan, Roberto Pagotan, Erika Galvez, Gregory M Fahy
Organs cryopreserved by vitrification are exposed to the lowest possible concentration of cryoprotectants for the least time necessary to successfully avoid ice formation. Faster cooling and warming rates enable lower concentrations and perfusion times, reducing toxicity. Since warming rates necessary to avoid ice formation during recovery from vitrification are typically faster than cooling rates necessary for vitrification, warming speed is a major determining factor for successful vitrification. Dielectric warming uses an oscillating electric field to directly heat water and cryoprotectant molecules inside organs to achieve warming that's faster and more uniform than can be achieved by heat conduction from the organ surface...
April 10, 2024: Cryobiology
#31
JOURNAL ARTICLE
Vladimir Gajdov, Goran Jokic, Sara Savic, Marina Zekic, Tanja Blazic, Milica Rajkovic, Tamas Petrovic
INTRODUCTION: This study aimed to investigate the prevalence and molecular characterization of Leptospira species in Belgrade, Serbia, an area where this disease is underexplored. Specifically, the study sought to employ molecular and multilocus sequence typing analyses to fill the gap in understanding the diversity and distribution of Leptospira species within the region. METHODS: A comprehensive molecular analysis was conducted on kidney samples obtained from Norway rats ( Rattus norvegicus ) in the urban environment...
2024: Frontiers in Microbiology
#32
JOURNAL ARTICLE
Mostafa Yousefian, Saeid Abedimanesh, Amirhossein Yadegar, Manouchehr Nakhjavani, S Zahra Bathaie
PURPOSE: We previously showed the beneficial effect of L-Lysine (Lys), a chemical chaperone, on reducing diabetic complications in diabetic rats and type 2 diabetic patients. Herein, we evaluated the effect of Lys co-administration with Vitamin C and Zinc (Lys+VC+Zn), in diabetic rats. METHODS: The streptozotocin (50 mg/Kg) was injected into male adult Wistar rats to induce diabetes. Then, different groups of normal and diabetic rats were treated with Lys and Lys+VC+Zn for five months...
April 9, 2024: Biomedicine & Pharmacotherapy
#33
JOURNAL ARTICLE
Marry A S Cirilo, Valéria B S Santos, Natália K S Lima, Humberto Muzi-Filho, Ana D O Paixão, Adalberto Vieyra, Leucio D Vieira
Paraquat (1,1'-dimethyl-4,4'-bipyridyl dichloride) is an herbicide widely used worldwide and officially banned in Brazil in 2020. Kidney lesions frequently occur, leading to acute kidney injury (AKI) due to exacerbated reactive O2 species (ROS) production. However, the consequences of ROS exposure on ionic transport and the regulator local renin-angiotensin-aldosterone system (RAAS) still need to be elucidated at a molecular level. This study evaluated how ROS acutely influences Na+-transporting ATPases and the renal RAAS...
2024: Anais da Academia Brasileira de Ciências
#34
JOURNAL ARTICLE
Marcus Dariva, Murilo Guedes, Vladimir Rigodon, Peter Kotanko, John W Larkin, Bruno Ferlin, Roberto Pecoits-Filho, Pasqual Barretti, Thyago Proença de Moraes
BACKGROUND: Hypertension is a leading cause of kidney failure, affects most dialysis patients and associates with adverse outcomes. Hypertension can be difficult to control with dialysis modalities having differential effects on sodium and water removal. There are two main types of peritoneal dialysis (PD), automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD). It is unknown whether one is superior to the other in controlling blood pressure (BP). Therefore, the aim of our study was to analyse the impact of switching between these two PD modalities on BP levels in a nationally representative cohort...
April 10, 2024: Peritoneal Dialysis International
#35
JOURNAL ARTICLE
Metages Ayele Akinaw, Suresh Kumar P Nair, Rashed Edris Usure, Bati Leta, Abdo Kedir, Selam Ayele Mamo, Nuredin Chura Waritu, Mohammed Jemal, Berhane Kebede Mulat
BACKGROUND: Drug-induced kidney injury was among the most common renal damages, from which gentamicin occupies around 25% of this injury. Gentamicin-induced renal damage is caused by increased free radicals with subsequent amplified inflammation. Ajuga remota leaf extract has many phytochemicals with antioxidant activities, which may improve gentamicin-induced renal damage. Thus, we aimed to investigate the nephroprotective effect of Ajuga remota leaf methanolic extract on gentamicin-induced nephrotoxicity in Swiss Albino Mice...
2024: Journal of Experimental Pharmacology
#36
JOURNAL ARTICLE
Lei Song, Dongyu Wang, Yuxia Zhai, Xiaoying Zhang, Yue Zhang, Yingli Yu, Likang Sun, Kun Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium sagittatum (Sieb. et Zucc.) Maxim. has been used traditionally in Asia. It can dispel wind and cold, tonify the kidney, and strengthen bones and tendons. However, adverse effects of E. sagittatum have been reported, and the underlying mechanisms remain unclear. AIM OF THE STUDY: This study aimed to investigate liver injury caused by an aqueous extract of E. sagittatum in Institute of Cancer Research (ICR) mice and explore its potential mechanisms...
April 7, 2024: Journal of Ethnopharmacology
#37
REVIEW
Agnieszka Pozdzik, Viridiana Grillo, Khashayar Sakhaee
With nephrolithiasis projected to affect 25% of the global population in the next three decades, there is an urgent call for innovative management strategies to prevent and reduce stone recurrence. This study aims to explore the evolving management needs in nephrolithiasis from both patient and healthcare provider perspectives. An expert-collaborative online survey comprising 10 targeted questions on kidney stone management was developed and disseminated. This survey was designed to gather comprehensive insights from patients, physicians and dietician and other person in the field of nephrolithiasis...
April 9, 2024: Urolithiasis
#38
JOURNAL ARTICLE
Osayimwen Imade, Bobola V Ilesanmi, Germaine O Ogunwole, Olusola O Elekofehinti, Marília Cristina Oliveira Souza, Fernando Barbosa, Chris O Adedire, Joseph A Adeyemi
The toxic effects of 2, 4-dichlorophenol (2, 4-DCP) on aquatic organisms are well-established; however, the details regarding the mechanisms underlying the toxicity, especially immunotoxicity are poorly understood. Consequently, the aim of this study was to investigate the histopathologic, oxidative stress and immunotoxic effects attributed to exposure to sublethal concentrations of 2,4-DCP in the African catfish, Clarias gariepinus . Juvenile C. gariepinus were exposed to 0.4, 0.8, or 1.6 mg/L 2, 4-DCP for 28 days after which blood and head kidney were extracted for the determination of various nonspecific innate immune parameters while the liver was excised for histopathology examination and measurement of oxidative stress biomarkers...
April 9, 2024: Journal of Toxicology and Environmental Health. Part A
#39
REVIEW
Prodipto Bishnu Angon, Md Shafiul Islam, Shreejana Kc, Arpan Das, Nafisa Anjum, Amrit Poudel, Shaharia Akter Suchi
Heavy metal (HM) poisoning of agricultural soils poses a serious risk to plant life, human health, and global food supply. When HM levels in agricultural soils get to dangerous levels, it harms crop health and yield. Chromium (Cr), arsenic (As), nickel (Ni), cadmium (Cd), lead (Pb), mercury (Hg), zinc (Zn), and copper (Cu) are the main heavy metals. The environment contains these metals in varying degrees, such as in soil, food, water, and even the air. These substances damage plants and alter soil characteristics, which lowers crop yield...
April 15, 2024: Heliyon
#40
JOURNAL ARTICLE
Atashpour Shekoufeh, Abedi Hassanali, Shafiei Jahromi Nazanin, Bagherzadeh Mohammad Aref, Saremi Jamileh, Mahjour Amirashkan, Kargar Jahromi Hossein
Kidneys are critical in the clearance and maintenance of active metabolites. One of the medical properties of Salep is treating bladder and kidney inflammation. Due to the widespread use of Salep in traditional medicine and the food industry, and since the effects of Salep on kidney function have not been studied, the present study aimed to investigate the impact of Salep on kidney function. In this experimental study, 48 male rats were divided randomly into six groups as control, sham, and four experimental groups receiving different doses of Salep intraperitoneally (80, 160, 320, and 640 mg/kg)...
October 2023: Archives of Razi Institute
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