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https://www.readbyqxmd.com/read/29908646/an-unusual-case-of-suicide-by-methanol-ingestion
#1
Brian Waters, Kenji Hara, Natsuki Ikematsu, Mio Takayama, Aya Matsusue, Masayuki Kashiwagi, Shin-Ichi Kubo
A female in her late teens purposely ingested alcohol fuel containing methanol to commit suicide, which she admitted on social media. She was found in distress by her parents and died at the hospital some hours later. Autopsy revealed swelling of the brain and edematous and congestive lungs. No other trauma or unusual findings were revealed at autopsy. Methanol was detected upon routine screening for alcohols by headspace gas chromatography with flame-ionization detection. To confirm the presence of methanol and its metabolite formic acid, a method with detection by mass spectrometry was used...
June 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29906393/bisphenol-a-in-eggs-impairs-the-long-term-stress-performance-of-rainbow-trout-in-two-generations
#2
Jith Thomas, Oana Birceanu, Bastien Sadoul, Mathilakath M Vijayan
Salmonids are ecologically, economically and culturally important fish species in North America, but whether contaminants in the environment may play a role in their population decline is unclear. We tested the hypothesis that BPA deposition in eggs, mimicking a maternal transfer scenario, compromises the stress axis functioning and target tissues stress response in two generations of a model salmonid species, the rainbow trout (Oncorhynchus mykiss). Eggs were enriched with 0, 4 or 40 ng BPA, fertilized, and reared in clean water for two generations...
June 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29903197/-effect-and-mechanism-of-three-kinds-of-drinking-water-on-blood-pressure-of-hypertensive-mice
#3
Qian Sun, Ronghe Chen, Fan Xin, Guohong Ruan
OBJECTIVE: To explore the effect of three kinds of drinking water and its possible mechanism on blood pressure of hypertensive mice. METHODS: The water quality parameters were measured for three kinds of drinking water, and the parameters includedtotal dissolved solids( TDS), oxygen consumed( OC), p H, oxidation reduction potential( ORP), electric conductivity( EC), dissolved hydrogen, calcium and magnesium. Establishment of mouse model of high blood pressure by using N'-nitro-L-arginine methyl ester hydrochloride( L-NAME) for 30 days...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29897643/cest-mri-of-sepsis-induced-acute-kidney-injury
#4
Jing Liu, Zheng Han, Guoli Chen, Yuguo Li, Jia Zhang, Jiadi Xu, Peter C M van Zijl, Shuixing Zhang, Guanshu Liu
Sepsis-induced acute kidney injury (SAKI) is a major complication of kidney disease associated with increased mortality and faster progression. Therefore, the development of imaging biomarkers to detect septic AKI is of great clinical interest. In this study, we aimed to characterize the endogenous chemical exchange saturation transfer (CEST) MRI contrast in the lipopolysaccharide (LPS)-induced SAKI mouse model and to investigate the use of CEST MRI for detecting such injury. We used a SAKI mouse model that was generated by i...
June 13, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29892792/the-renal-blood-flow-reserve-in-healthy-humans-and-patients-with-atherosclerotic-renovascular-disease-measured-by-positron-emission-tomography-using-15-o-h-2-o
#5
Johanna Päivärinta, Niina Koivuviita, Vesa Oikonen, Hidehiro Iida, Kaisa Liukko, Ilkka Manner, Eliisa Löyttyniemi, Pirjo Nuutila, Kaj Metsärinne
BACKGROUND: Microvascular function plays an important role in ARVD (atherosclerotic renovascular disease). RFR (renal flow reserve), the capacity of renal vasculature to dilate, is known to reflect renal microvascular function. In this pilot study, we assessed PET (positron emission tomography)-based RFR values of healthy persons and renal artery stenosis patients. Seventeen patients with ARVD and eight healthy subjects were included in the study. Intravenous enalapril 1 mg was used as a vasodilatant, and the maximum response (blood pressure and RFR) to it was measured at 40 min...
June 11, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29891955/a-systematic-evaluation-of-the-biocompatibility-of-cucurbit-7-uril-in-mice
#6
Xiangjun Zhang, Xiaoqiu Xu, Shengke Li, Lian-Hui Wang, Jianxiang Zhang, Ruibing Wang
As one of the most water-soluble members in the macrocyclic cucurbit[n]uril (CB[n]) family, CB[7] has attracted increasing attention in pharmaceutical and biomedical fields. Despite extensive studies regarding the potential use of CB[7] for biomedical applications, its full safety and toxicity profile in a clinically relevant model is still lacking. Herein we report the full biocompatibility profile of CB[7], administered orally, peritoneally or intravenously in mice, respectively. Body-weight changes showed no significant differences among various groups of mice after they were administered with CB[7] at a single dose of 5 g/kg orally, 500 mg/kg peritoneally and 150 mg/kg intravenously, respectively...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29890881/comparative-assessment-on-mechanism-underlying-renal-toxicity-of-commercial-formulation-of-roundup-herbicide-and-glyphosate-alone-in-male-albino-rat
#7
Gabriel A Dedeke, Folarin O Owagboriaye, Kehinde O Ademolu, Olanrewaju O Olujimi, Adeyinka A Aladesida
There have been major concerns that the nephrotoxicity of commercial formulations of Roundup herbicide is due to the active ingredient glyphosate. We therefore investigated and compared the mechanisms underlining the nephrotoxicity of Roundup herbicide and glyphosate alone in rat. Fifty-six adult male rats randomized into 7 groups of 8 rats per group were exposed to Roundup formulation and glyphosate alone daily by gavage at 3.6, 50.4, and 248.4 mg/kg body weight (bw) of glyphosate concentrations for 12 weeks with distilled water administered to the control group...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29890435/acute-and-subacute-toxicity-study-of-olaquindox-by-feeding-to-common-carp-cyprinus-carpio-l
#8
Qian Yang, Jie He, Sheng-Yu He, Kai-Yu Wang, Yi Geng, De-Fang Chen, Xiao-Li Huang, Ping Ou-Yang
Olaquindox, is a growth-promoting feed additive for food-producing animals. As the banned medicinal feed additive, olaquindox in animal feed and water must be concerned as an important hazard index. To improve studies of the toxicity of olaquindox, we provide a toxicological effects of olaquindox on a common freshwater fish, Cyprinus carpio L. The results of acute toxicity tests showed that the 7d-LD50 of olaquindox administered by feeding for common carp was determined to be 3746.3 mg/kg. We also found that the accumulation coefficient of olaquindox in carp was 1...
June 8, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29888573/-kidney-reinforcing-and-governor-vessel-regulating-ea-intervention-may-improve-learningmemory-possibly-by-suppressing-formation-of-senile-plaques-in-hippocampus-in-app-ps-1-double-transgenic-alzheimer-s-disease-mice
#9
Qing-Hua Yang, Ling Guo, Qing Chen, Kai-Hui Wu, Yan-Jun Wu, Yan Jia, Shu-Juan Zhu, Cheng-Lin Tang, Hua-Jun Sheng
OBJECTIVE: To observe the effect of electroacupuncture (EA) intervention on learning-memory ability and the expression of senile plaques (SP), amyloid precursor protein (APP), β-secretase 1(BACE 1) and insulin degrading enzyme (IDE) in the hippocampus in APP/presenilin 1 (PS 1) double transgenic Alzheimer's disease (AD) mice, so as to reveal its mechanisms underlying improvement of AD. METHODS: A total of 18 male APP/PS 1 double transgenic AD mice were randomly divided into model, EA-2-week and EA-3-week groups ( n =6 in each)...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29887760/toxicological-assessment-of-pseudospondias-microcarpa-a-rich-engl-hydroethanolic-leaf-extract-in-rats-haematological-biochemical-and-histopathological-studies
#10
Donatus Wewura Adongo, Priscilla Kolibea Mante, Kennedy Kwami Edem Kukuia, Charles Kwaku Benneh, Robert Peter Biney, Eric Boakye-Gyasi, Nicholas Akinwale Titiloye, Eric Woode
Pseudospondias microcarpa is used traditionally for treating various diseases. However, although parts of the plant are extensively used in African traditional medicine, no scientific study has been reported on its toxicity. Therefore, this study evaluated the acute and subacute toxicity studies of the ethanolic extract of P. microcarpa in rats. Male Sprague-Dawley rats (120-150 g) were treated orally with the extract (30, 100, 300, 1000, and 3000 mg kg-1 ) or distilled water (10 ml kg-1 ) for 2 weeks and observed daily for general appearance and signs of toxicity...
2018: TheScientificWorldJournal
https://www.readbyqxmd.com/read/29886313/differential-biochemical-responses-to-metal-metalloid-accumulation-in-organs-of-an-edible-fish-centropomus-parallelus-from-neotropical-estuaries
#11
Iara da C Souza, Mariana Morozesk, Marina M Bonomo, Vinicius C Azevedo, Marise M Sakuragui, Michael Elliott, Silvia T Matsumoto, Daniel A Wunderlin, María V Baroni, Magdalena V Monferrán, Marisa N Fernandes
Metal/metalloid accumulation in fish organs elicits biochemical responses indicating the overall fish and environmental health status. This study evaluated the bioaccumulation of metals and metalloid in relation to a suite of biochemical biomarkers (superoxide dismutase, catalase, glutathione-S-transferase, Na+/K+-ATPase, H+-ATPase, acetylcholinesterase activities and the levels of glutathione, metallothionein, lipid peroxidation and oxidized protein) in different organs of fish, Centropomus parallelus, in Vitória Bay and Santa Cruz estuaries (State of Espírito Santo, Brazil) with distinct contamination levels...
June 7, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29886290/pharmacokinetic-bioavailability-and-tissue-distribution-study-of-mp3950-a-new-gastroprokinetic-candidate-compound-in-rat-using-uplc-ms-ms
#12
Yu Zhao, Min Zhao, Qi Jiang, Feng Qin, Chengying Wang, Zhili Xiong, Shaojie Wang, Zhonggui He, Xingjie Guo, Longshan Zhao
MP3950 is being developed as a gastroprokinetic candidate compound. To illustrate the pharmacokinetic profiles, absolute bioavailability after intravenous administration and oral administration with MP3950 as well as tissue distribution in vivo, an UPLC-MS/MS approach which was rapid and selective was developed to determine MP3950 in plasma and tissue of rat. Sample pre-treatment of plasma sample was one-step protein precipitation. 0.1% formic acid containing 5 mmol/L ammonium acetate-methanol(55/45,v/v) was used for isocratic elution on a Waters ACQUITY UPLC® BEH C18 (50 mm × 2...
June 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29886233/acute-and-subchronic-toxicities-of-the-ethanol-and-hot-water-extracts-from-chinese-sumac-rhus-chinensis-mill-fruits-by-oral-administration-in-rats
#13
Zihuan Wu, Yanli Ma, Lei Zhao, Shengbao Cai, Guiguang Cheng
In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg...
June 7, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29886105/esrd-and-esrd-dm-associated-with-lignite-containing-aquifers-in-the-u-s-gulf-coast-region-of-arkansas-louisiana-and-texas
#14
Ann S Ojeda, Jeffrey Widener, Christopher E Aston, R Paul Philp
Balkan endemic nephropathy (BEN) is an irreversible, lethal kidney disease that occurs in regions of the Balkans where residents drink untreated well water. A key factor contributing to the development of BEN may be consumption of dissolved organic matter leached from low-rank coal called lignite. This hypothesis-known as lignite-water hypothesis-was first posed for areas of the Balkans. It is possible that a BEN-like condition exists in the United States (US) Gulf Coast region in parts of the Mississippi Embayment and the Texas Coastal Uplands aquifers -Arkansas, Louisiana, and Texas, for instance-that rely heavily on groundwater from aquifers that contain lignite...
May 4, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29885393/novel-alginate-di-aldehyde-cross-linked-gelatin-nano-hydroxyapatite-bioscaffolds-for-soft-tissue-regeneration
#15
M Mehedi Hasan, M Nuruzzaman Khan, Papia Haque, Mohammed Mizanur Rahman
The present study describes the fabrication of a novel alginate-di-aldehyde (ADA) cross-linked gelatin (GEL)/nano-hydroxyapatite (nHAp) bioscaffold by lyophilization process. The physico-chemical properties of the scaffolds were evaluated in order to assess its suitability for tissue engineering application. ADA was prepared from periodate oxidation of alginate which facilitate the crosslinking between free amino group of gelatin and available aldehyde group of ADA through Schiff's base formation. nHAp was synthesized from waste egg-shells by wet chemical method...
June 6, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29883689/molecular-characterization-of-na-k-2cl-cotransporter-1-alpha-from-trachinotus-ovatus-linnaeus-1758-and-its-expression-responses-to-acute-salinity-stress
#16
Chao-Ping Zhao, Hua-Yang Guo, Ke-Cheng Zhu, Liang Guo, Nan Zhang, Bao-Suo Liu, Jing-Wen Yang, Bo Liu, Shi-Gui Jiang, Dian-Chang Zhang
Trachinotus ovatus is a stenohaline fish and widely cultured in the ponds and gulf on the southeast coast of China. The dramatic salinity decrease caused by heavy rainfall could cause mass mortality of T. ovatus in aquaculture. It is very important to understand the osmoregulatory mechanism of T. ovatus. Na+ /K+ /2Cl- cotransporter 1a (NKCC1a) is involved in the osmoregulation of fish and plays a crucial role in cell volume homeostasis and maintenance of the electrolyte content. In this study, we characterized nkcc1a (designed as Tonkcc1a) from T...
June 5, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29883246/glyphosate-and-ampa-of-agricultural-soil-surface-water-groundwater-and-sediments-in-areas-prevalent-with-chronic-kidney-disease-of-unknown-etiology-sri-lanka
#17
Shankani Gunarathna, Buddhika Gunawardana, Mahesh Jayaweera, Jagath Manatunge, Kasun Zoysa
Glyphosate, which is commercially available as Roundup®, was the widely used herbicide in Sri Lanka until 2015 and is suspected to be one of the causal factors for Chronic Kidney Disease of unknown etiology (CKDu). This research, therefore, aims at studying the presence of glyphosate and Aminomethylphosphonic acid (AMPA) in different environmental matrices in CKDu prevalent areas. Topsoil samples from agricultural fields, water samples from nearby shallow wells and lakes, and sediment samples from lakes were collected and analyzed for glyphosate and AMPA using the LC/MS...
June 8, 2018: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/29881418/pre-treatment-with-erythropoietin-attenuates-bilateral-renal-ischemia-induced-cognitive-impairments
#18
Mahshid Tahamtan, Vahid Sheibani, Seyed Mostafa Shid Moosavi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Iraj Aghaei, Mohammad Shabani
One of the most common causes of mortality in acute kidney injury is brain dysfunction. Here we investigated the possible protective effect of erythropoietin (EPO) on cognitive impairments induced by bilateral renal ischemia (BRI). Eighty male Wistar rats were allocated into 8 groups: 1, 2) Sham +V (Vehicle), 3, 4) Sham+EPO, 5, 6) BRI+V, 7, 8) BRI+EPO. The groups followed by the reperfusion periods of 24hours (24 h) and 1week (1w). EPO or saline was administrated 30 min before surgery (1000 IU/kg, i.p). The cognitive function was assessed by passive avoidance learning and Morris water maze tests...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29880355/evaluation-of-subclinical-fluid-overload-using-lung-ultrasound-and-estimated-plasma-volume-in-the-postoperative-period-following-kidney-transplantation
#19
C Mottola, N Girerd, S Coiro, Z Lamiral, P Rossignol, L Frimat, S Girerd
AIM: B-lines count measured with lung ultrasound (LUS) quantifies extravascular lung water and is validated in the setting of acute cardiac failure or chronic dialysis. Patients are often kept in moderately overhydrated states during the early postoperative period following kidney transplantation (KT). We described congestion changes during the early postoperative period following KT and the feasibility of LUS in this setting. METHODS: LUS (28 scanning-points method) and inferior vena cava (IVC) measurements were routinely performed in 36 patients after KT...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29879756/a-novel-liquid-chromatography-orbitrap-mass-spectrometry-method-with-full-scan-for-simultaneous-determination-of-multiple-bioactive-constituents-of-shenkang-injection-in-rat-tissues-application-to-tissue-distribution-and-pharmacokinetic-studies
#20
Jie Yang, Zhi Sun, Duolu Li, Fei Duan, Zhuolun Li, Jingli Lu, Yingying Shi, Tanye Xu, Xiaojian Zhang
Shenkang injection is a traditional Chinese formula with good curative effect on chronic renal failure. In this paper, a novel, rapid and sensitive ultra high performance liquid chromatography coupled with Q Exactive hybrid quadrupole orbitrap high resolution accurate mass spectrometry was developed and validated for simultaneous determination of seven bioactive constituents of Shenkang injection in rat plasma and tissues after intravenous administration. Acetonitrile was used as protein precipitation agent in biological samples dispose with carbamazepine as internal standard...
June 7, 2018: Biomedical Chromatography: BMC
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