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Fatigue and Parkinson's disease

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https://www.readbyqxmd.com/read/29681884/glutathione-s-transferase-alpha-4-prevents-dopamine-neurodegeneration-in-a-rat-alpha-synuclein-model-of-parkinson-s-disease
#1
Michael Jewett, Elna Dickson, Kajsa Brolin, Matilde Negrini, Itzia Jimenez-Ferrer, Maria Swanberg
Parkinson's disease (PD) is a common, progressive neurodegenerative disease, which typically presents itself with a range of motor symptoms, like resting tremor, bradykinesia, and rigidity, but also non-motor symptoms such as fatigue, constipation, and sleep disturbance. Neuropathologically, PD is characterized by loss of dopaminergic cells in the substantia nigra pars compacta (SNpc) and Lewy bodies, neuronal inclusions containing α-synuclein (α-syn). Mutations and copy number variations of SNCA , the gene encoding α-syn, are linked to familial PD and common SNCA gene variants are associated to idiopathic PD...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29670566/non-motor-symptoms-of-parkinson-s-disease-and-their-impact-on-quality-of-life-in-a-cohort-of-moroccan-patients
#2
Houyam Tibar, Khalil El Bayad, Ahmed Bouhouche, El Hachmia Ait Ben Haddou, Ali Benomar, Mohamed Yahyaoui, Abdelhamid Benazzouz, Wafa Regragui
Background: Non-motor symptoms (NMSs) are a real burden in Parkinson's disease (PD). They may appear in early pre-symptomatic stage as well as throughout the disease course. However, their relationship with the deterioration of the patient's quality of life (QoL) is still under debate. This study aimed to investigate the prevalence of NMSs and their impact on the QoL in a cohort of Moroccan patients. Methods: We carried out a cross-transactional study, where a total of 117 patients were submitted to a structured clinical interview and examination investigating motor and NMSs based on common and conventional scales...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29648576/life-space-mobility-in-parkinson-s-disease-associations-with-motor-and-non-motor-symptoms
#3
Merja Rantakokko, Susanne Iwarsson, Björn Slaug, Maria H Nilsson
Background: To describe life-space mobility and explore associations of motor and non-motor symptoms with life-space mobility in people with Parkinson's disease (PD). Methods: 164 community-dwelling persons with PD (mean age 71.6 years, 64.6% men) received a postal survey and a subsequent home visit. Motor assessments included perceived walking difficulties (Walk-12G), mobility (Timed Up and Go test), motor symptoms (UPDRS-III) and freezing of gait (item 3, FOG-Qsa)...
April 10, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29643593/characteristics-associated-with-freezing-of-gait-in-actual-daily-living-in-parkinson-s-disease
#4
Mitsuaki Ishii, Kohei Okuyama
[Purpose] Parkinson's disease (PD) patients often freeze in actual daily living but seldom in clinical setting. This study aimed to identify the factors contributing to freezing of gait (FOG). [Subjects and Methods] The participants included 28 adults with PD. Principal component analysis was used to investigate the characteristics of 14 common FOG situations adopted from previous studies. Cluster analysis classified the subjects into four groups. Kruskal-Wallis test was performed to compare the PD Questionnaire-39 mobility dimension between the groups...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29597014/fatigue-in-parkinson-s-disease-metric-properties-of-the-fatigue-impact-scale-for-daily-use-d-fis-and-its-impact-on-quality-of-life
#5
Marcos Serrano-Dueñas, Rosaura Bravo, Tamara Merchán, Maite Serrano
OBJECTIVE: In Parkinson's disease patients, fatigue is a disabling non-motor symptom whose prevalence ranges from 28% to 58%. The Fatigue Impact Scale for Daily Use (D-FIS), one of the various scales for quantifying fatigue. The aim of our study was to analyze the metric properties of the D-FIS in PD subjects and assess the impact of fatigue on their quality of life. PATIENTS AND METHODS: The cohort in this study was comprised of 211 consecutive patients with a PD diagnosis regularly followed up at the Movement Disorders Unit of the Neurology Department at Carlos Andrade Marín Hospital (HCAM) in Quito, Ecuador, according to the United Kingdom PD Society Brain Bank criteria...
March 22, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29593637/structural-and-functional-brain-patterns-of-non-motor-syndromes-in-parkinson-s-disease
#6
REVIEW
Tino Prell
Parkinson's disease (PD) is a common, progressive and multisystem neurodegenerative disorder characterized by motor and non-motor symptoms. Advanced magnetic resonance imaging, positron emission tomography, and functional magnetic resonance imaging can render the view toward understanding the neural basis of these non-motor syndromes, as they help to understand the underlying pathophysiological abnormalities. This review provides an up-to-date description of structural and functional brain alterations in patients with PD with cognitive deficits, visual hallucinations, fatigue, impulsive behavior disorders, sleep disorders, and pain...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29568693/acupuncture-in-the-treatment-of-fatigue-in-parkinson-s-disease-a-pilot-randomized-controlled-study
#7
Keng H Kong, Hwee L Ng, Wei Li, Dora W Ng, Siang I Tan, Kay Y Tay, Wing L Au, Louis C S Tan
Introduction: Fatigue is a common and disabling problem in patients with Parkinson's disease (PD), and there is currently no satisfactory treatment. As acupuncture has been reported to be effective in fatigue related to other conditions, we sought to evaluate its efficacy in PD. Methods: This was a single center, randomized, sham-controlled study. Forty PD patients with moderately severe fatigue were randomized to receive 5 weeks of biweekly real or sham acupuncture...
January 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29566588/effectiveness-of-reset-a-strategic-executive-treatment-for-executive-dysfunctioning-in-patients-with-parkinson-s-disease
#8
Thialda T Vlagsma, Annelien A Duits, Hilde T Dijkstra, Teus van Laar, Jacoba M Spikman
In this multicentre randomised controlled trial (RCT), 43 patients with Parkinson's disease (PD) were randomly allocated to either the experimental condition receiving cognitive rehabilitation including strategy training (ReSET; Strategic Executive Treatment, n = 24) or to the control condition receiving computerised repetitive practice training for attention (Cogniplus, n = 16). We expected that strategy training (ReSET) would be more effective than cognitive training (Cogniplus) in improving patients' everyday life executive functioning...
March 22, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29547479/effects-of-fatigue-on-balance-in-individuals-with-parkinson-disease-influence-of-medication-and-brain-derived-neurotrophic-factor-genotype
#9
Michael Baer, Bradley Klemetson, Diana Scott, Andrew S Murtishaw, James W Navalta, Jefferson W Kinney, Merrill R Landers
BACKGROUND AND PURPOSE: Because falls can have deleterious consequences, it is important to understand the influence of fatigue and medications on balance in persons with Parkinson disease (PD). Thus, the purpose of this study was to investigate the effects of fatigue on balance in individuals with PD. Because brain-derived neurotrophic factor (BDNF) has been shown to be related to motor performance, we also explored its role. METHODS: A total of 27 individuals (age = 65...
April 2018: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/29526800/effects-of-parkinson-disease-and-antiparkinson-medication-on-central-adaptations-to-repetitive-grasping
#10
Michael J Falvo, John W Rohrbaugh, Thomas Alexander, Gammon M Earhart
Cortical activity during motor task performance is attenuated in individuals with Parkinson disease (PD) relative to age-matched adults without PD, and this activity is enhanced with antiparkinson medication. It remains unclear, however, whether the relative change in cortical activity over the duration of the task, i.e., central adaptation, is affected individuals with PD, and if so, whether medication corrects for any unique behaviors. Movement-related cortical potentials (MRCPs) were recorded from scalp electrode sites Cz and C1 during 150 repetitive handgrip contractions at 70% of maximal voluntary contraction, in individuals with PD (n = 10) both ON and OFF of their PD medication, and neurologically normal age- and sex-matched controls (n = 10)...
March 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/29515451/physical-exercise-induced-cardiovascular-and-thermoregulatory-adjustments-are-impaired-in-rats-subjected-to-cutaneous-artery-denervation
#11
Milene R Malheiros-Lima, Washington Pires, Ivana A T Fonseca, Julliane V Joviano-Santos, Anderson J Ferreira, Cândido C Coimbra, Nilo R V Lima, Samuel P Wanner
This study aimed to investigate the chronic effects of caudal artery denervation on morphometric parameters of the tail vascular smooth muscle and on physical exercise-induced thermoregulatory and cardiovascular adjustments in rats. Male Wistar rats were subjected to caudal artery denervation or the sham procedure. Approximately 26-28 days after these procedures, their thermoregulatory and cardiovascular parameters were evaluated at rest and during or following a fatiguing treadmill run. At the end of the experiments, the rats were euthanized, and samples of their tails were removed to evaluate morphometric parameters of the vascular smooth muscle surrounding the caudal artery...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29511826/efficacy-and-safety-of-amantadine-for-the-treatment-of-l-dopa-induced-dyskinesia
#12
REVIEW
Santiago Perez-Lloret, Olivier Rascol
L-DOPA induced dyskinesias (LIDs) may affect up to 40% of Parkinson's disease (PD) and impact negatively health-related quality of life. Amantadine has demonstrated significant antidyskinetic effects in animal PD models and in randomized double-blind placebo-controlled trials (RCTs) in patients with PD. These effects are thought to be related to the blockade of NMDA receptors modulating cortico-striatal glutamatergic-dopaminergic interactions involved in the genesis of LIDs. There are three pharmaceutical forms of amantadine currently available in the market: an oral immediate-release (IR) formulation, which is widely available; an extended-release (ER) formulation (ADS-5102) which has been recently developed and approved by the FDA; and an intravenous infusion (IV) solution, which is not commonly used in clinical practice...
March 7, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29447582/clinical-characteristics-and-quality-of-life-in-chinese-patients-with-parkinson-s-disease-beyond-20-years
#13
Ruwei Ou, Yanbing Hou, Wei Song, Qianqian Wei, Yongping Chen, Bei Cao, Xiaoqin Yuan, Huifang Shang
Background The number of Parkinson's disease (PD) patients with disease duration of more than 20 years (long disease duration PD, LPD) is on the rise. Objectives This study aims to describe the clinical profiles and the quality of life (QoL) of LPD patients from a cohort of the Chinese population. Methods We compared 71 LPD subjects to 60 PD patients who died less than 20 years after the onset of PD (control PD, CPD). A regression model was constructed to assess the determinants for 20 years survival and the QoL of LPD patients...
April 2018: Neurological Research
https://www.readbyqxmd.com/read/29445332/motor-unit-action-potential-clustering-theoretical-consideration-for-muscle-activation-during-a-motor-task
#14
Michael J Asmussen, Vinzenz von Tscharner, Benno M Nigg
During dynamic or sustained isometric contractions, bursts of muscle activity appear in the electromyography (EMG) signal. Theoretically, these bursts of activity likely occur because motor units are constrained to fire temporally close to one another and thus the impulses are "clustered" with short delays to elicit bursts of muscle activity. The purpose of this study was to investigate whether a sequence comprised of "clustered" motor unit action potentials (MUAP) can explain spectral and amplitude changes of the EMG during a simulated motor task...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29431985/tremor-sorting-through-the-differential-diagnosis
#15
Paul Crawford, Ethan E Zimmerman
Tremor is an involuntary, rhythmic, oscillatory movement of a body part. It is the most common movement disorder encountered in primary care. The diagnosis of tremor is based on clinical information obtained from the history and physical examination. The most common tremors in patients presenting to primary care physicians are enhanced physiologic tremor, essential tremor, and parkinsonian tremor. All persons have low-amplitude, high-frequency physiologic tremors at rest and during action that are not reported as symptomatic, but can be enhanced by anxiety, medication use, caffeine intake, or fatigue...
February 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29409156/fatigue-in-parkinson-s-disease-concepts-and-clinical-approach
#16
REVIEW
Daniel V Nassif, João S Pereira
Parkinson's disease (PD) is a progressive neurological disorder characterized by a large number of motor and non-motor features. Fatigue is one of the most common and most disabling symptoms among patients with PD, and it has a significant impact on their quality of life. Although fatigue has been recognized for a long time, its pathophysiology remains poorly understood, and there is no evidence to support any therapeutic approach in PD patients. Expert consensus on case definition and diagnostic criteria for PD-related fatigue have been recently published, and although they still need to be adequately validated, they provide a great step forward in the study of fatigue...
February 6, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29406900/symptomatic-orthostatic-hypotension-in-parkinson-s-disease-patients-prevalence-associated-factors-and-its-impact-on-balance-confidence
#17
Siranan Klanbut, Siripan Phattanarudee, Supakit Wongwiwatthananukit, Chuthamanee Suthisisang, Roongroj Bhidayasiri
BACKGROUND: Orthostatic hypotension (OH) is a commonly reported sign of the cardiovascular autonomic dysfunctions associated with Parkinson's disease (PD). Patients might suffer from a variety of the clinical symptoms of OH, including dizziness, lightheadedness, or problems with vision and fatigue. OBJECTIVES: To determine the prevalence of, and factors associated with, symptomatic orthostatic hypotension (OH) in Parkinson's disease (PD) and to identify any relationships between the clinical symptoms of OH and balance confidence in this patient population...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29392077/clinical-profile-of-chinese-long-term-parkinson-s-disease-survivors-with-10-years-of-disease-duration-and-beyond
#18
Qian Sun, Tian Wang, Tian-Fang Jiang, Pei Huang, Ying Wang, Qin Xiao, Jun Liu, Sheng-Di Chen
Background: Parkinson's disease (PD) patients with 10 years or more survival (PD-10) are not well characterized. The aim of this study was to evaluate the main issues facing PD-10 patients and identify factors that independently contributed to quality of life (QoL). Methods: A group of 121 PD-10 patients recruited from outpatient clinics participated in this cross-sectional study. Data on demographic and clinical factors were collected. Multiple linear regression analyses were conducted to identify determinants of poor QoL...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29390272/efficacy-and-safety-of-sqjz-herbal-mixtures-on-nonmotor-symptoms-in-parkinson-disease-patients-protocol-for-a-randomized-double-blind-placebo-controlled-trial
#19
Jing Shi, Jinzhou Tian, Ting Li, Bin Qin, Dongsheng Fan, Jingnian Ni, Mingqing Wei, Xuekai Zhang, Na Liu, Jianping Liu, Yumeng Li, Weiwei Liu, Yongyan Wang
BACKGROUND: As a multisystemic neurodegenerative disorder, Parkinson disease (PD) has a broad spectrum of symptoms including motor and nonmotor symptoms (NMS). As shown in studies, NMS can also impact patient's quality of life, and many of them often go untreated. Chinese herbal medicines with multiconstituent may alleviate NMS in PD patients. This research is carried out to assess the efficacy and safety of a Chinese herbal formula for NMS, with its Chinese name acronym of SQJZ. METHODS/DESIGN: It will be a multicenter, randomized, double-blind, placebo-controlled trial...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29368093/parkinson-s-disease-the-dopaminergic-neuron-and-gammahydroxybutyrate
#20
Mortimer Mamelak
The high energy demands of the substantia nigra pars compacta dopaminergic (DASNc) neurons render these neurons vulnerable to degeneration. These energy demands are a function of their long and extensively arborized axons and very large number of transmitter release sites, and are further augmented by their natural pacemaking activity. Pacemaking is driven by the rhythmic entry of Ca2+ into the cell and, while the entry of Ca2+ into the neuron stimulates energy (ATP) production, the extrusion of Ca2+ conversely saps the energy that is generated...
January 24, 2018: Neurology and Therapy
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