keyword
MENU ▼
Read by QxMD icon Read
search

Fatigue and Parkinson's disease

keyword
https://www.readbyqxmd.com/read/28089250/pathology-of-behavior-in-pd-what-is-known-and-what-is-not
#1
REVIEW
Kaylena A Ehgoetz Martens, Simon J G Lewis
Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia...
December 29, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28087059/fatigue-in-parkinson-s-disease
#2
REVIEW
Karen Herlofson, Benzi M Kluger
Fatigue is one of the most common nonmotor symptoms in Parkinson's disease and may affect a wide range of everyday activities, cause disability and reduce quality of life. It occurs at every stage of PD, and once present will often persist and may worsen over time. Lack of a consensus of definition and classification, and a range of different self-reporting scales has so far made the study of fatigue challenging. We review a unifying taxonomy for defining fatigue in clinical and research contexts as well as case definition criteria for PD-related fatigue...
December 29, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28044431/abnormal-resting-state-neural-activity-and-connectivity-of-fatigue-in-parkinson-s-disease
#3
Jie-Jin Zhang, Jian Ding, Jun-Yi Li, Min Wang, Yong-Sheng Yuan, Li Zhang, Si-Ming Jiang, Xi-Xi Wang, Lin Zhu, Ke-Zhong Zhang
AIMS: Fatigue is a common burdensome problem in patients with Parkinson's disease (PD), but its pathophysiological mechanisms are poorly understood. This study aimed at investigating the neural substrates of fatigue in patients with PD. METHODS: A total of 17 PD patients with fatigue, 32 PD patients without fatigue, and 25 matched healthy controls were recruited. The 9-item fatigue severity scale (FSS) was used for fatigue screening and severity rating. Resting-state functional magnetic resonance imaging (RS-fMRI) data were obtained from all subjects...
January 3, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27994352/assessment-of-fatigue-in-parkinson-s-disease-indian-perspective
#4
Birinder Singh Paul, Amandeep Singh, Dinesh Jain, Gagandeep Singh, Sandeep Kaushal, Gunchan Paul, Karan Kaura
CONTEXT: Fatigue is one of the most frequent nonmotor manifestations in Parkinson's disease (PD), having a major effect on quality of life but is not reported in Indian patients. AIMS: To evaluate the frequency of fatigue in a cohort of PD population and its correlation with disease. SETTINGS AND DESIGN: Fatigue Severity Scale (FSS) was translated and validated in local vernacular language. All patients of PD visiting neurology outpatient department of a tertiary care hospital...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27994228/serotonergic-dysfunctions-and-abnormal-iron-metabolism-relevant-to-mental-fatigue-of-parkinson-disease
#5
Li-Jun Zuo, Shu-Yang Yu, Yang Hu, Fang Wang, Ying-Shan Piao, Teng-Hong Lian, Qiu-Jin Yu, Rui-Dan Wang, Li-Xia Li, Peng Guo, Yang Du, Rong-Yan Zhu, Zhao Jin, Ya-Jie Wang, Xiao-Min Wang, Piu Chan, Sheng-Di Chen, Yong-Jun Wang, Wei Zhang
Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and abnormal iron metabolism are still unknown. Therefore, we evaluated the fatigue symptoms, classified PD patients into fatigue group and non-fatigue group, and detected the levels of serotonin, iron and related proteins in CSF and serum. In CSF, 5-HT level is significantly decreased and the levels of iron and transferrin are dramatically increased in fatigue group...
December 2016: Scientific Reports
https://www.readbyqxmd.com/read/27993522/non-motor-symptoms-and-the-quality-of-life-in-multiple-system-atrophy-with-different-subtypes
#6
LingYu Zhang, Bei Cao, RuWei Ou, Qian-Qian Wei, Bi Zhao, Jing Yang, Ying Wu, HuiFang Shang
BACKGROUND: The differences in non-motor symptoms (NMS) and quality of life (QOL) between MSA patients with different subtypes remain unknown, so do the determinants of poor QOL in both subtypes. METHODS: A total of 172 MSA patients were enrolled in the study. NMS of patients with MSA were assessed using the non-motor symptoms scale (NMSS) and Parkinson's Disease Questionnaire-39 item version (PDQ-39) was used to evaluate the QOL of patients with MSA. RESULTS: The most prevalent NMS domain was urinary (91...
December 13, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27965875/measuring-prefrontal-cortical-activity-during-dual-task-walking-in-patients-with-parkinson-s-disease-feasibility-of-using-a-new-portable-fnirs-device
#7
Freek Nieuwhof, Miriam F Reelick, Inbal Maidan, Anat Mirelman, Jeffrey M Hausdorff, Marcel G M Olde Rikkert, Bastiaan R Bloem, Makii Muthalib, Jurgen A H R Claassen
BACKGROUND: Many patients with Parkinson's disease (PD) have difficulties in performing a second task during walking (i.e., dual task walking). Functional near-infrared spectroscopy (fNIRS) is a promising approach to study the presumed contribution of dysfunction within the prefrontal cortex (PFC) to such difficulties. In this pilot study, we examined the feasibility of using a new portable and wireless fNIRS device to measure PFC activity during different dual task walking protocols in PD...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27796604/repeated-sessions-of-transcranial-direct-current-stimulation-evaluation-on-fatigue-and-daytime-sleepiness-in-parkinson-s-disease
#8
Bijan Forogh, Maryam Rafiei, Amin Arbabi, Mohammad Reza Motamed, Seyed Pezhman Madani, Simin Sajadi
Parkinson is a common and disabling disease that affects patient's and career's quality of life. Unfortunately, medications, such as dopaminergic and sedative-hypnotic drugs, as an effective treatment have unwilling side effects. Recently, Transcranial Direct Current Stimulation (tDCS) in conjunction with medication becomes popular as a complementary safe treatment and several studies have proved its effectiveness on controlling motor and specially non-motor aspects of Parkinson's disease. In this randomized double-blind parallel study, 23 patients with Parkinson's disease divided into two groups of real tDCS plus occupational therapy and sham tDCS plus occupational therapy and the effects of therapeutic sessions (eight sessions tDCS with 0...
October 31, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27783210/attention-in-parkinson-s-disease-with-fatigue-evidence-from-the-attention-network-test
#9
Caterina Pauletti, Daniela Mannarelli, Nicoletta Locuratolo, Luca Pollini, Antonio Currà, Lucio Marinelli, Steno Rinalduzzi, Francesco Fattapposta
Fatigue is a non-specific symptom that is common in chronic diseases and represents one of the most disabling symptoms in Parkinson's disease. PD patients often experience cognitive deficits related above all to executive functions. The relationship between cognitive changes and fatigue in PD patients has not been explored in depth. The Attention Network Test (ANT) is a rapid, widely used test to measure the efficiency of three attentional networks, i.e., alerting, orienting, and executive, by evaluating reaction times (RTs) in response to visual stimuli...
October 25, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27772747/il-6-serum-levels-are-elevated-in-parkinson-s-disease-patients-with-fatigue-compared-to-patients-without-fatigue
#10
Jéssica Ramos Pereira, Lílian Viana Dos Santos, Renata Maria Silva Santos, Ana Luíza Figueiredo Campos, André Lana Pimenta, Mateus Silva de Oliveira, Geander Gaburro Bacheti, Natália Pessoa Rocha, Antônio Lúcio Teixeira, Paulo Pereira Christo, Paula Luciana Scalzo
To investigate the influence of interleukin-6 (IL-6) and soluble tumor necrosis factor receptors (sTNFR) in fatigued Parkinson's disease (PD) patients. Forty-four PD patients were evaluated, and fatigue was assessed with the Parkinson Fatigue Scale. Logistic regression analysis was used to evaluate the contribution of disease severity scores and cytokine levels on fatigue scores. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic values of IL-6 in fatigue. Fatigued PD patients had worse cognitive function and depressive symptoms...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27726132/factors-associated-with-life-satisfaction-in-parkinson-s-disease
#11
K Rosqvist, P Hagell, P Odin, H Ekström, S Iwarsson, M H Nilsson
OBJECTIVES: To identify factors associated with life satisfaction (LS) in people with Parkinson's disease (PD), including a specific focus on those with late-stage PD. MATERIAL AND METHODS: The study included 251 persons with PD (median age 70 years; PD duration 8 years). Analyses involved the total sample and a subsample with late-stage PD, that is Hoehn and Yahr stages IV and V (n=62). LS was assessed with item 1 of the Life Satisfaction Questionnaire (LiSat-11)...
October 10, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27699949/thoughts-on-fatigue-in-parkinson-s-disease-and-other-disorders
#12
EDITORIAL
J H Friedman
No abstract text is available yet for this article.
January 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27670392/fatigue-in-early-parkinson-s-disease-the-norwegian-parkwest-study
#13
S O Ongre, J P Larsen, O B Tysnes, K Herlofson
BACKGROUND AND PURPOSE: Fatigue is a common and disabling non-motor symptom in Parkinson's disease (PD). The pathogenesis is unknown, and the treatment options are limited. The aim of the present study was to investigate the development of fatigue during the first year after diagnosis. METHODS: The study design was a prospective, controlled population-based longitudinal cohort study, comprising 181 de novo, drug-naïve patients with PD and 162 control participants...
January 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27618849/clinical-presentation-of-anxiety-in-parkinson-s-disease-a-scoping-review
#14
Sara G Lutz, Jeffrey D Holmes, Emily A Ready, Mary E Jenkins, Andrew M Johnson
Up to 40% of all individuals with Parkinson's disease (PD) are estimated to experience anxiety that interferes with daily functioning. This article describes research regarding the presentation of anxiety in PD and the influence anxiety has on participation in this population. A scoping review identified 1,635 articles, of which 49 met the inclusion criteria. This review identified that anxiety in PD is often associated with a range of clinical correlates related to demographic and clinical characteristics (age, gender, disease stage, duration, progression), motor symptoms (tremor, bradykinesia, dystonia, freezing of gait, symptom severity), treatment-related complications (on/off fluctuations, on with dyskinesia, unpredictable off), and non-motor symptoms (sleep abnormalities, fatigue, cognitive impairment, depression)...
July 2016: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/27610060/the-effects-of-below-knee-compression-garments-on-functional-performance-in-individuals-with-parkinson-disease
#15
Veronica Southard, Joanne DiFrancisco-Donoghue, James Mackay, Stephanie Idjadi, Neil Wright
BACKGROUND: Symptoms of Parkinson's disease (PD) include bradykinesia, gait abnormalities, balance deficits, restless leg syndrome, and muscular fatigue. Compression garments (CG) have been shown to improve performance in athletes by increasing venous return and reduce lactic acid. OBJECTIVE: Assess the effect of compression garments on the performance of 3 standardized functional tests in persons with PD. METHODOLOGY: The functional tests selected represented strength, endurance, and mobility measures in individuals with PD...
July 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27602175/acupuncture-for-symptomatic-treatment-of-fatigue-in-parkinson-s-disease-trial-design-and-implementation
#16
Lisa Corbin, Rebecca Childs, Caitlin Dilli, Mary K Christian, Ban Wong, Daisy Dong-Cedar, Benzi M Kluger
Background: Acupuncture use is increasing worldwide for many conditions, including movement disorders. Clinical research in acupuncture has also increased to test anecdotal reports of clinical benefits empirically and investigate potential mechanisms. Method: This article describes considerations for designing a double-blinded, randomized, placebo-controlled clinical trial of acupuncture for fatigue in Parkinson's disease (PD) and describes the current authors' experience in the implementation and early conduct of this trial...
August 1, 2016: Medical Acupuncture
https://www.readbyqxmd.com/read/27600158/an-objective-measure-combining-physical-and-cognitive-fatigability-correlation-with-subjective-fatigue-in-parkinson-s-disease
#17
Davide Martino, Tiziano Tamburini, Panagiotis Zis, Gavril Rosoklija, Giovanni Abbruzzese, Kallol Ray-Chaudhuri, Elisa Pelosin, Laura Avanzino
BACKGROUND: Objective measures of physical and cognitive fatigability do not correlate with subjective Parkinson's disease (PD)-related fatigue. The relationship of subjective PD-related fatigue to tasks combining cognitive and motor effort has never been explored. METHODS: Forty-four right-handed, non-demented PD patients, 22 with (PD-F) and 22 without (PD-NF) fatigue, were tested using a sensor-engineered glove on their more affected hand. Patients performed sequential opposition finger movements following a metronome at 2 Hz for 5 min (cued task), and for another minute following a 2-min rest...
August 31, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27583249/the-impact-of-physical-activity-on-non-motor-symptoms-in-parkinson-s-disease-a-systematic-review
#18
REVIEW
Melanie E Cusso, Kenneth J Donald, Tien K Khoo
Parkinson's disease (PD) is a neurological disorder that is associated with both motor and non-motor symptoms (NMS). The management of PD is primarily via pharmaceutical treatment; however, non-pharmaceutical interventions have become increasingly recognized in the management of motor and NMS. In this review, the efficacy of physical activity, including physiotherapy and occupational therapy, as an intervention in NMS will be assessed. The papers were extracted between the 20th and 22nd of June 2016 from PubMed, Web of Science, Medline, Ovid, SportsDiscuss, and Scopus using the MeSH search terms "Parkinson's," "Parkinson," and "Parkinsonism" in conjunction with "exercise," "physical activity," "physiotherapy," "occupational therapy," "physical therapy," "rehabilitation," "dance," and "martial arts...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27574730/placebo-effects-from-pain-to-motor-performance
#19
Elisa Carlino, Giulia Guerra, Alessandro Piedimonte
The placebo effect can be elicited by two main mechanisms: via classical conditioning and cognitive expectations. These two mechanisms have been traditionally investigated in one single domain. The aim of the present study is to investigate how a placebo effect obtained in one modality (pain tolerance) can be transferred to another modality (motor endurance) and which mechanisms (i.e. reinforced expectation/conditioning or expectations alone) are more responsible for this placebo transferability. Participants were tested in a pain tolerance task and in a motor task in two different experiments: after a conditioning procedure on pain tolerance in which they were made to believe in the effectiveness of an analgesic treatment procedure (experiment 1) or without a previous conditioning procedure (experiment 2)...
October 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27573215/non-motor-symptoms-in-portuguese-parkinson-s-disease-patients-correlation-and-impact-on-quality-of-life-and-activities-of-daily-living
#20
Paulo Bugalho, Tânia Lampreia, Rita Miguel, Marcelo D Mendonça, André Caetano, Raquel Barbosa
The prevalence of non-motor symptoms (NMS) in Parkinson's Disease (PD) has varied between studies. Their interrelation isn't totally understood. Also, the relative importance of each symptom, regarding its impact on activities of daily living (ADL) and health related quality of life (HRQL), remains debatable. We assessed all PD patients attending a Portuguese tertiary movement disorders center during one year (n = 134), with ADL, HRQL and other clinical scales approved for identifying the most relevant NMS in PD...
2016: Scientific Reports
keyword
keyword
81185
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"