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pre-operative radiotherapy

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https://www.readbyqxmd.com/read/28890811/tumor-stage-in-patients-operated-for-rectal-cancer-a-comparison-of-the-pre-operative-mr-and-the-resection-specimen-with-specific-attention-to-the-effect-of-neo-adjuvant-radiotherapy
#1
Elmer E van Eeghen, Sandra D Bakker, Gerwin Fransen, Marcel J Flens, Ruud J L F Loffeld
BACKGROUND: Evaluate the preoperative TN stage with MR and the postoperative stage with histology. METHODS: Patients diagnosed with rectal cancer (2002-2015) and a pre-operative MR were included. A chart review was done. Pathology reports were evaluated for the post-operative tumor stage. Down staging was defined as a lower disease stage in the resection specimen compared with the pre-operative MR. Upgrading ("progression") was defined as a higher disease stage in the resection specimen...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28882187/nadir-psa-is-a-strong-predictor-of-treatment-outcome-in-intermediate-and-high-risk-localized-prostate-cancer-patients-treated-by-definitive-external-beam-radiotherapy-and-androgen-deprivation
#2
Fady B Geara, Muhammad Bulbul, Raja B Khauli, Therese Y Andraos, Mirna Abboud, Abdelatif Al Mousa, Nasim Sarhan, Ahmed Salem, Hamza Ghatasheh, Anoud Alnsour, Zeina Ayoub, Ibrahim Abu Gheida, Maya Charafeddine, Mohammed Shahait, Ali Shamseddine, Rami Abu Gheida, Jamal Khader
BACKGROUND: The aim of this study is to investigate the effect of tumor characteristics and parameters of treatment response in predicting biochemical disease-free survival (BFS) for patients with intermediate or high risk prostate cancer treated by combined definitive external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT). METHODS: Between June 1995 and January 2015, 375 patients with localized prostate cancer and a National Comprehensive Cancer Network (NCCN) intermediate or high risk categories were treated by definitive EBRT and ADT...
September 7, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28878597/the-advantages-of-transurethral-resection-of-the-prostate-in-patients-with-an-elevated-or-rising-prostate-specific-antigen-mild-or-moderate-lower-urinary-tract-symptoms-bladder-outlet-obstruction-and-negative-prostate-cancer-imaging-or-prostate-biopsies-a-prospective
#3
Evert Baten, Koenraad van Renterghem
OBJECTIVE: To investigate elevated or rising prostate specific antigen (PSA) as a marker for bladder outlet obstruction (BOO) in patients with minor lower urinary tract symptoms (LUTS) and without prostate cancer. MATERIALS AND METHODS: One hundred and five consecutive patients were prospectively analyzed between 2005 and 2013. All patients were referred to the principal investigator by their general practitioner as a result of an elevated and/or rising PSA. Only patients with minor LUTS [International Prostate Symptom Score (I-PSS) 0-19] and without suspicion for prostate cancer were included...
August 2017: Current Urology
https://www.readbyqxmd.com/read/28867324/surgical-management-and-outcomes-of-intracranial-chondromas-a-single-center-case-series-of-66-patients
#4
Jian-Cong Weng, Da Li, Huan Li, Jun-Peng Ma, Kai-Bing Tian, Liang Wang, Li-Wei Zhang, Zhen Wu, Jun-Ting Zhang
OBJECTIVE: Management of intracranial chondromas (ICDs) is difficult. This study aims to propose a tailored management strategy based on our management of ICDs. METHODS: A retrospective review was performed in 66 patients who received surgical operations at our institute. Clinical charts and radiographs were reviewed, follow-up was performed, and adverse factors for progression-free survival (PFS) and overall survival (OS) were evaluated. RESULTS: The pre- and postoperative KPS was 81...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28859058/preoperative-chemoradiation-with-capecitabine-irinotecan-and-cetuximab-in-rectal-cancer-significance-of-pre-treatment-and-post-resection-ras-mutations
#5
Simon Gollins, Nick West, David Sebag-Montefiore, Arthur Sun Myint, Mark Saunders, Shabbir Susnerwala, Phil Quirke, Sharadah Essapen, Leslie Samuel, Bruce Sizer, Jane Worlding, Katie Southward, Gemma Hemmings, Emma Tinkler-Hundal, Morag Taylor, Daniel Bottomley, Philip Chambers, Emma Lawrie, Andre Lopes, Sandy Beare
BACKGROUND: The influence of EGFR pathway mutations on cetuximab-containing rectal cancer preoperative chemoradiation (CRT) is uncertain. METHODS: In a prospective phase II trial (EXCITE), patients with magnetic resonance imaging (MRI)-defined non-metastatic rectal adenocarinoma threatening/involving the surgical resection plane received pelvic radiotherapy with concurrent capecitabine, irinotecan and cetuximab. Resection was recommended 8 weeks later. The primary endpoint was histopathologically clear (R0) resection margin...
August 31, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28842782/optimal-post-operative-radiation-after-soft-tissue-sarcoma-resection-is-achieved-in-less-than-two-thirds-of-cases
#6
Laurent Casabianca, Sarah Kreps, Sylvie Helfre, Martin Housset, Philippe Anract, David J Biau
PURPOSE: Local control of soft tissue sarcomas frequently involves adjuvant radiation to the surgical resection. When opting for post-operative radiation, care should be taken that radiation is started within some reasonable time after the surgery. We were interested to the proportion of patients who did not recieve optimal post-operative radiation and the variables associated. METHODS: We retrospectively analyzed a series of 77 patients operated on for an extremity soft-tissue sarcoma and due for post-operative radiotherapy...
August 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28748803/serial-mri-scan-of-posterior-fossa-tumours-predict-patients-at-risk-of-developing-neurocognitive-impairment
#7
Ramadhan Othman, Kurdistan Gh Abdullah
Background: Brain tumours are the most common solid tumours in children. More than 50% of these tumours develop in the posterior cranial fossa. Long term survivors of posterior fossa tumours (PFT) suffer from neurocognitive and memory issues. We hypothesized that serial MRI scanning of brain would show differences in hippocampal and ACC volume change in PFT patients treated with and without chemo-radiotherapy. Material and Methods: Twelve patients (8 females and 4 males) underwent 76 serial MR imaging examinations before and during treatment for posterior fossa tumours...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28741376/rate-of-symptomatic-lymphocele-formation-after-extraperitoneal-vs-transperitoneal-robot-assisted-radical-prostatectomy-and-bilateral-pelvic-lymphadenectomy
#8
David Horovitz, Xiang Lu, Changyong Feng, Edward M Messing, Jean V Joseph
INTRODUCTION AND OBJECTIVE: With the peritoneum acting as a natural surface for lymphatic reabsorption, transperitoneal robot-assisted radical prostatectomy (tRARP) is thought to be associated with a lower incidence of symptomatic lymphoceles (SLs) compared with its extraperitoneal counterpart (eRARP) when bilateral pelvic lymph node dissection (BPLND) is performed. In this study, we aim to determine if there is a difference in SL formation and characteristics between the two approaches...
August 30, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28741123/neoadjuvant-radiotherapy-is-associated-with-r0-resection-and-improved-survival-for-patients-with-extremity-soft-tissue-sarcoma-undergoing-surgery-a-national-cancer-database-analysis
#9
Alicia A Gingrich, Sarah B Bateni, Arta M Monjazeb, Morgan A Darrow, Steven W Thorpe, Amanda R Kirane, Richard J Bold, Robert J Canter
BACKGROUND: Neoadjuvant radiotherapy (RT) is increasingly advocated for the management of soft tissue sarcoma (STS). Therefore, this study sought to characterize the impact of neoadjuvant RT on rates of R0 resection and overall survival (OS) in extremity STS patients undergoing surgery. METHODS: From January 2003 to December 2012, the study identified patients with a diagnosis of extremity STS from the National Cancer Database. After exclusion of patients younger than 18 years, not treated by surgery, who had metastases at diagnosis, intraoperative RT, and missing or unknown data, 27,969 patients were identified...
July 24, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28712533/dose-volume-toxicity-modeling-for-de-intensified-chemo-radiation-therapy-for-hpv-positive-oropharynx-cancer
#10
Panayiotis Mavroidis, Alex Price, David Fried, Mark Kostich, Robert Amdur, William Mendenhall, Chihray Liu, Shiva Das, Lawrence B Marks, Bhishamjit Chera
BACKGROUND AND PURPOSE: The aim is to determine the radiobiological parameters of four popular normal tissue complication probability (NTCP) models that describe the dose-response relations of salivary glands and pharyngeal constrictors to the severity of patient reported xerostomia and dysphagia, respectively 6 and 12months post chemo-radiotherapy, furthermore, to evaluate the goodness-of-fit of the NTCP models for different combinations of glands and constrictors. MATERIAL AND METHODS: Forty-three patients were treated on a prospective multi-institutional phase II study (ClinicalTrials...
July 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28698004/the-effect-of-radiotherapy-on-fat-content-and-fatty-acids-in-myxoid-liposarcomas-quantified-by-mri
#11
Mikael Skorpil, Henric Rydén, Johan Wejde, Elisabet Lidbrink, Otte Brosjö, Johan Berglund
BACKGROUND: Myxoid liposarcomas are highly radiosensitive. Consequently radiotherapy is often used pre-operatively to reduce tumor volume and lessen the post-operative deficit. In soft-tissue sarcomas therapy response is mainly evaluated using magnetic resonance imaging (MRI) and the fundamental criterion for a positive response is decreased tumor size. In myxoid liposarcomas an increased fat content is also known to occur as a response to radiotherapy. OBJECTIVE: To highlight the difficulties of MRI for therapy response evaluation in irradiated myxoid liposarcomas, by using MRI Dixon techniques enabling objective quantification of proton density fat fraction (%) and the number of double bonds (ndb; unsaturation degree) of fatty acids...
July 8, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28685404/analysis-of-factors-influencing-the-access-to-concomitant-chemo-radiotherapy-in-elderly-patients-with-high-grade-gliomas-role-of-mmse-age-and-tumor-volume
#12
Andrea Di Cristofori, Barbara Zarino, Claudia Fanizzi, Giorgia Abete Fornara, Giulio Bertani, Paolo Rampini, Giorgio Carrabba, Manuela Caroli
High grade gliomas (HGG) are tumors with a rapidly progressive course and the standard of care consists of surgery and chemo-radiotherapy. Elderly patients with HGG usually have a worse prognosis due to their comorbidities and difficulties in accessing or completing adjuvant treatments. The purpose of our study was to assess the influence of pre-operative factors (MMSE, age, sex, KPS, tumor volume) on the post-operative access to chemo-radiotherapy in the elderly population. In addition, the influence of the access to adjuvant therapies on overall survival (OS) was assessed...
July 6, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28664443/vacuum-assisted-early-transanal-closure-of-leaking-low-colorectal-anastomoses-the-clean-study
#13
W A A Borstlap, G D Musters, L P S Stassen, H L van Westreenen, D Hess, S van Dieren, S Festen, E J van der Zaag, P J Tanis, W A Bemelman
INTRODUCTION: Non-healing of anastomotic leakage can be observed in up to 50% after total mesorectal excision for rectal cancer. This study investigates the efficacy of early transanal closure of anastomotic leakage after pre-treatment with the Endosponge(®) therapy. METHODS: In this prospective, multicentre, feasibility study, transanal suturing of the anastomotic defect was performed after vacuum-assisted cleaning of the presacral cavity. Primary outcome was the proportion of patients with a healed anastomosis at 6 months after transanal closure...
June 29, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28642179/analysis-of-outcomes-of-multidisciplinary-management-of-gliosarcoma-a-single-centre-study-2000-2013
#14
Abhinav Jain, Jason Correia, Patrick Schweder, Adele McMahon, Joseph Merola, Robert Aspoas
BACKGROUND: Gliosarcoma is a rare CNS tumour with a reported incidence of ∼2-8% of all gliomas. We reviewed the outcomes of patients treated at our institution over a 14-year period from 2000-2013 to characterize overall and progression free survival as well as to elucidate the additive effect of chemo-radiotherapy. METHODS: For the duration of 01/01/2000 to 31/12/2013, we retrospectively reviewed the clinical notes of all patients treated at our institution with a histopathological diagnosis of Gliosarcoma...
June 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28636472/benign-tumors-of-the-parotid-gland-a-retrospective-study-of-339-patients
#15
Marie Quiriny, Cécile Dekeyser, Michel Moreau, Antoine Digonnet, Esther Willemse, Laurent Vanbel, Guy Andry
AIM: Among 339 patients operated for benign tumor of the parotid gland: the recurrences and the postoperative complications rates were compared WITH those published in literature. MATERIALS AND METHODS: About 339 patients operated: 274 primarily and 65 for recurrence or residual tumor. VARIABLES: sex, age, surgical techniques, pre- or postoperative radiotherapy, histology, size and localization of the tumors, disease free intervals, recurrences and postoperative complications...
February 10, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28611300/consistency-mapping-of-16-lymph-node-stations-in-gastric-cancer-by-ct-based-vessel-guided-delineation-of-255-patients
#16
Shuhang Xu, Lingling Feng, Yongming Chen, Ying Sun, Yao Lu, Shaomin Huang, Yang Fu, Rongqin Zheng, Yujing Zhang, Rong Zhang
In order to refine the location and metastasis-risk density of 16 lymph node stations of gastric cancer for neoadjuvant radiotherapy, we retrospectively reviewed the initial images and pathological reports of 255 gastric cancer patients with lymphatic metastasis. Metastatic lymph nodes identified in the initial computed tomography images were investigated by two radiologists with gastrointestinal specialty. A circle with a diameter of 5 mm was used to identify the central position of each metastatic lymph node, defined as the LNc (the central position of the lymph node)...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28602265/diep-flap-for-breast-reconstruction-is%C3%A2-abdominal-fat-thickness-associated-with-post-operative-complications
#17
Ali Modarressi, Camillo Theo Müller, Xavier Montet, Eva Meia Rüegg, Brigitte Pittet-Cuénod
INTRODUCTION: Some surgeons consider a high body mass index (BMI) or important abdominal fat excess as contraindications for breast reconstruction with free deep inferior epigastric perforator (DIEP) flap. This study aimed to identify factors associated with post-operative complications by using this type of flap, with an emphasis on BMI and abdominal subcutaneous fat thickness. METHODS: A retrospective chart review of 105 consecutive patients who underwent DIEP flap breast reconstruction at our institution was performed to assess post-operative complications...
August 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28578652/icorg-10-14-neoadjuvant-trial-in-adenocarcinoma-of-the-oesophagus-and-oesophagogastric-junction-international-study-neo-aegis
#18
J V Reynolds, S R Preston, B O'Neill, L Baeksgaard, S M Griffin, C Mariette, S Cuffe, M Cunningham, T Crosby, I Parker, K Hofland, G Hanna, L B Svendsen, C L Donohoe, C Muldoon, D O'Toole, C Johnson, N Ravi, G Jones, A K Corkhill, M Illsley, J Mellor, K Lee, M Dib, V Marchesin, M Cunnane, K Scott, P Lawner, S Warren, S O'Reilly, G O'Dowd, G Leonard, B Hennessy, R Mc Dermott
BACKGROUND: Neoadjuvant therapy is increasingly the standard of care in the management of locally advanced adenocarcinoma of the oesophagus and junction (AEG). In randomised controlled trials (RCTs), the MAGIC regimen of pre- and postoperative chemotherapy, and the CROSS regimen of preoperative chemotherapy combined with radiation, were superior to surgery only in RCTs that included AEG but were not powered on this cohort. No completed RCT has directly compared neoadjuvant or perioperative chemotherapy and neoadjuvant chemoradiation...
June 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28575242/prognostic-significance-of-the-prognostic-nutritional-index-in-esophageal-cancer-patients-undergoing-neoadjuvant-chemotherapy
#19
M Nakatani, K Migita, S Matsumoto, K Wakatsuki, M Ito, H Nakade, T Kunishige, M Kitano, H Kanehiro
Nutritional status is one of the most important issues faced by cancer patients. Several studies have shown that a low preoperative nutritional status is associated with a worse prognosis in patients with various types of cancer, including esophageal cancer (EC). Recently, neoadjuvant chemotherapy (NAC) and/or radiotherapy have been accepted as the standard treatment for resectable advanced EC. However, NAC has the potential to deteriorate the nutritional status of a patient. This study aimed to evaluate the prognostic significance of the nutritional status for EC patients who underwent NAC...
August 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28565890/influence-of-nodal-status-on-the-surgical-outcome-for-bronchongenic-carcinoma-involving-the-carina-a-systematic-review-and-meta-analysis
#20
Hai Lin, Yadong Lu, Tao Gu, Jun Wang
BACKGROUND: Bronchogenic carcinomas involving the carina or the tracheo-bronchial angle represents a challenging surgical procedure because of difficult surgical techniques and complex ventilation procedures. Eventhough surgical outcomes for this type of procedure has improved over time, the need for surgical management of patients with metastatic mediastinal nodes, that is those that are graded N2 or higher according to the TNM classification, is still controversial. METHODS: We searched Pubmed, Embase and CNKI for literature in English or Chinese reporting on this subject, with information on survival rates or survival curves for groups with different grades of nodal status...
May 30, 2017: Minerva Chirurgica
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