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pre-operative radiotherapy

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https://www.readbyqxmd.com/read/29779799/impact-of-low-skeletal-muscle-mass-on-non-lung-cancer-mortality-after-stereotactic-body-radiotherapy-for-patients-with-stage-i-non-small-cell-lung-cancer
#1
Yukinori Matsuo, Takamasa Mitsuyoshi, Takashi Shintani, Yusuke Iizuka, Takashi Mizowaki
PURPOSE: The purpose of the present study was to retrospectively evaluate impact of pre-treatment skeletal muscle mass (SMM) on overall survival and non-lung cancer mortality after stereotactic body radiotherapy (SBRT) for patients with stage I non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: One-hundred and eighty-six patients whose abdominal CT before the treatment was available were enrolled into this study. The patients were divided into two groups of SMM according to gender-specific thresholds for unilateral psoas area...
May 17, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29777894/endoscopic-transnasal-resection-of-solitary-fibrous-tumor-in-the-optic-canal
#2
Seiei Torazawa, Masahiro Shin, Hirotaka Hasegawa, Ryohei Otani, Keisuke Ueki, Nobuhito Saito
BACKGROUND: Tumors extending into the optic canal can cause progressive visual impairment due to optic nerve compression, and prompt surgical resection is often necessary. When the tumor is located medially in the optic canal, endoscopic transnasal surgery provides a safer, less invasive alternative to trans-cranial approach. CASE DESCRIPTION: We recently encountered a case of small solitary fibrous tumor in the optic canal causing rapid visual deterioration. The radiographic findings of pre-operative imaging studies were compatible with those of meningioma; however, unlike meningioma, bleeding from the tumor was very profuse during the operation...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29747544/deep-hyperthermia-with-the-hypercollar-system-combined-with-irradiation-for-advanced-head-and-neck-carcinoma-a-feasibility-study
#3
G M Verduijn, E M de Wee, Z Rijnen, P Togni, J A U Hardillo, I Ten Hove, M Franckena, G C van Rhoon, M M Paulides
PURPOSE: Radiotherapy (RT) treatment of locally-advanced and recurrent head and neck carcinoma (HNC) results in disappointing outcomes. Combination of RT with cisplatin or cetuximab improves survival but the increased toxicity and patient's comorbidity warrant the need for a less-toxic radiosensitizer. Stimulated by several randomized studies demonstrating the radio-sensitizing effect of hyperthermia, we developed the HYPERcollar. Here, we report early experience and toxicity in patients with advanced HNC...
May 11, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29744471/outcomes-of-salvage-radical-prostatectomy-following-more-than-one-failed-local-therapy
#4
Arjun Sivaraman, Peter Scardino, James Eastham
Purpose: To describe the salvage radical prostatectomy (sRP) experience in patients presenting with recurrent, clinically localized prostate cancer after multiple failed local treatments. Materials and Methods: Among the 251 sRP performed during 2000-2016, 11 patients had failed multiple local therapies. We describe baseline clinical characteristics at primary cancer diagnosis and prior to sRP, surgical information, complications and oncological outcomes. Results: The mean±standard deviation age at sRP was 65±5 years and the median (interquartile range) serum prostate-specific antigen (PSA) level was 2 (1...
May 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29739453/spontaneous-renal-hemorrhage-secondary-to-choriocarcinoma-in-a-man-with-congenital-hypospadias-and-cryptorchidism-a-case-report-and-literature-review
#5
Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-Yu Xiong, Zi-Yi Yang, Yun-Xiao Zhu, Nathan Jeffreys
BACKGROUND: Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcinoma has previously been only reported in females. We present what we believe to be the first case of a male patient with genital malformation (hypospadias and cryptorchidism) and SRH at presentation of choriocarcinoma. CASE PRESENTATION: A 25-year-old man presented to the department with intense pain in the right flank region and lower back...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29736685/emerging-trends-in-the-management-of-brain-metastases-from-non-small-cell-lung-cancer
#6
REVIEW
Thomas M Churilla, Stephanie E Weiss
PURPOSE OF REVIEW: To summarize current approaches in the management of brain metastases from non-small cell lung cancer (NSCLC). RECENT FINDINGS: Local treatment has evolved from whole-brain radiotherapy (WBRT) to increasing use of stereotactic radiosurgery (SRS) alone for patients with limited (1-4) brain metastases. Trials have established post-operative SRS as an alternative to adjuvant WBRT following resection of brain metastases. Second-generation TKIs for ALK rearranged NSCLC have demonstrated improved CNS penetration and activity...
May 7, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29699878/the-role-of-red-cell-distribution-width-in-the-locoregional-recurrence-of-laryngeal-cancer
#7
Gülpembe Bozkurt, Arzu Yasemin Korkut, Pınar Soytaş, Senem Kurt Dizdar, Zeynep Nur Erol
INTRODUCTION: Although the red cell distribution width has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge few reports have focused on the prognostic value of red cell distribution width in laryngeal carcinoma. OBJECTIVE: We aimed to explore whether the pretreatment red cell distribution width predicted recurrence in laryngeal cancer patients is a simple, reproducible, and inexpensive prognostic biomarker. METHODS: All laryngeal cancer patients who underwent curative surgery (n=132) over a 7 year study period were evaluated...
April 13, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29686838/smoking-is-predictive-of-poorer-distant-metastasis-free-and-progression-free-survival-in-soft-tissue-sarcoma-patients-treated-with-pre-operative-radiotherapy-or-chemoradiotherapy
#8
Nicholas P Gannon, David M King, Manpreet Bedi
Background: Soft tissue sarcomas (STS) are often treated with pre-operative radiation (RT), with or without chemotherapy, followed by wide local excision. Prognosis for these patients involves an interplay of tumor and patient characteristics. Known prognostic determinants include tumor size, grade, response to therapy, and patient characteristics such as age. While smoking is negatively correlated with outcomes in various malignancies, the impact on STS is unknown. We aimed to assess if smoking impacts overall (OS), distant metastasis-free (DMFS), and progression-free (PFS) survival in patients with STS treated with pre-operative RT...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29681402/-clinical-practice-for-morbidly-obese-endometrial-cancer-patients-a-french-multicentric-study
#9
Cécile Loaec, Edouard Vaucel, Eric Darnis, Patrice Lopes, Gabrielle Selmes, Isabelle Jaffre, Jean-Marc Classe
INTRODUCTION: Morbid obesity may lead to difficulties for management of endometrial cancer. The aim of this study was the assessment of management of endometrial cancer for morbidly obese women and the implementation of recommendations. METHODS: this is retrospective study including women with BMI ≥40kg/m2 treated for endometrial cancer between November 2010 and April 2017 in the university hospital in Nantes and the Cancer Center René Gauducheau in Nantes. Patients' demographics, pre-operative intra operative, post-operative data and survival were analyzed...
April 19, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29657889/pre-operative-versus-post-operative-radiosurgery-for-brain-metastasis-effects-on-treatment-volume-and-inter-observer-variability
#10
B A Vellayappan, J Doody, E Vandervoort, J Szanto, J Sinclair, J M Caudrelier, S Malone
Purpose/Objectives: Compared to post-operative whole brain radiotherapy, resection cavity radiosurgery reduces impact on neuro-cognitive function and improves quality-of-life. However, coverage of the operative tract, in addition to tumour bed, may lead to large treatment volumes and inter-observer variability. We hypothesized that pre-operative radiosurgery reduces target volume size and inter-observer variability compared to post-operative radiosurgery. Materials/Methods: We identified 10 consecutive patients, with solitary brain metastasis, treated with post-operative cavity radiosurgery...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29623208/a-rare-challenging-case-of-co-existent-craniopharyngioma-acromegaly-and-squamous-cell-lung-cancer
#11
Athanasios Fountas, Shu Teng Chai, John Ayuk, Neil Gittoes, Swarupsinh Chavda, Niki Karavitaki
Co-existence of craniopharyngioma and acromegaly has been very rarely reported. A 65-year-old man presented with visual deterioration, fatigue and frontal headaches. Magnetic resonance imaging revealed a suprasellar heterogeneous, mainly cystic, 1.9 × 2 × 1.9 cm mass compressing the optic chiasm and expanding to the third ventricle; the findings were consistent with a craniopharyngioma. Pituitary hormone profile showed hypogonadotropic hypogonadism, mildly elevated prolactin, increased insulin-like growth factor 1 (IGF-1) and normal thyroid function and cortisol reserve...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29614361/effectiveness-of-pet-ct-as-a-guide-for-palliative-radiation-therapy-for-spinal-metastases
#12
Neil D Almeida, Crystal Adams, Gregory L Davis, Justin Buro, Nadim Nasr, Don McRae, George Cernica, Anthony Caputy, Robert Hong, Jonathan Sherman
BACKGROUND: As back pain is the presenting symptoms in 95% of patients with epidural spinal metastases, appropriately identifying and treating the most symptomatic levels can provide significant palliation. OBJECTIVE: The purpose of this study is to analyze the ability of PET-CT to identify spinal metastases with high metabolic activity and guide radiotherapy. We sought to correlate improvement in back pain with reduction in SUV uptake following treatment. METHODS: We conducted a retrospective review of 72 patients with bony spinal metastases treated with stereotactic ablative radiation therapy at a single center between 2002 and 2014...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29610659/survival-is-influenced-by-approaches-to-local-treatment-of-ewing-sarcoma-within-an-international-randomised-controlled-trial-analysis-of-eicess-92
#13
Jeremy Whelan, Allan Hackshaw, Anne McTiernan, Robert Grimer, David Spooner, Jessica Bate, Andreas Ranft, Michael Paulussen, Herbert Juergens, Alan Craft, Ian Lewis
Background: Two national clinical trial groups, United Kingdom Children's Cancer and Leukaemia Group (CCLG) and the German Paediatric Oncology and Haematology Group (GPOH) together undertook a randomised trial, EICESS-92, which addressed chemotherapy options for Ewing's sarcoma. We sought the causes of unexpected survival differences between the study groups. Methods: 647 patients were randomised. Cox regression analyses were used to compare event-free survival (EFS) and overall survival (OS) between the two study groups...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29557486/treatment-related-features-improve-machine-learning-prediction-of-prognosis-in-soft-tissue-sarcoma-patients
#14
Jan C Peeken, Tatyana Goldberg, Christoph Knie, Basil Komboz, Michael Bernhofer, Francesco Pasa, Kerstin A Kessel, Pouya D Tafti, Burkhard Rost, Fridtjof Nüsslin, Andreas E Braun, Stephanie E Combs
BACKGROUND AND PURPOSE: Current prognostic models for soft tissue sarcoma (STS) patients are solely based on staging information. Treatment-related data have not been included to date. Including such information, however, could help to improve these models. MATERIALS AND METHODS: A single-center retrospective cohort of 136 STS patients treated with radiotherapy (RT) was analyzed for patients' characteristics, staging information, and treatment-related data. Therapeutic imaging studies and pathology reports of neoadjuvantly treated patients were analyzed for signs of response...
March 20, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29544754/superficial-temporal-versus-cervical-recipient-vessels-in-maxillary-and-midface-free-vascularized-tissue-reconstruction-our-14-year-experience
#15
Jun Li, Yi Shen, Liang Wang, Jin-Bing Wang, Jian Sun, Thorsen W Haugen
PURPOSE: The aims of this study are to review our surgical experience in maxillary and midface reconstruction using free vascularized tissue and to compare the postoperative outcomes based on superficial temporal versus cervical recipient vessels. MATERIALS AND METHODS: We performed a retrospective review of patients who underwent maxillary and midface reconstruction with free vascularized tissue from March 2001 to July 2014. Two groups were analyzed: those in whom superficial temporal vessels were used as the recipient vessels and those in whom cervical vessels were used as the recipient vessels...
February 20, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29530071/a-multidisciplinary-team-oriented-intervention-to-increase-guideline-recommended-care-for-high-risk-prostate-cancer-a-stepped-wedge-cluster-randomised-implementation-trial
#16
Bernadette Brown, Jane Young, David P Smith, Andrew B Kneebone, Andrew J Brooks, Sam Egger, Miranda Xhilaga, Amanda Dominello, Dianne L O'Connell, Mary Haines
BACKGROUND: This study assessed whether a theoretically conceptualised tailored intervention centred on multidisciplinary teams (MDTs) increased clinician referral behaviours in line with clinical practice guideline recommendations. METHODS: Nine hospital Sites in New South Wales (NSW), Australia with a urological MDT and involvement in a state-wide urological clinical network participated in this pragmatic stepped wedge, cluster randomised implementation trial...
March 12, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29516955/three-dimensional-printed-individual-template-guided-125-i-seed-implantation-for-the-cervical-lymph-node-metastasis-a-dosimetric-and-security-study
#17
Yansong Liang, Zeyang Wang, Hongtao Zhang, Zhen Gao, Jinxin Zhao, Aixia Sui, Jing Zhao, Zezhou Liu, Juan Wang
Objective: The objective of this study is to evaluate the dosimetric accuracy and pathway safety of the three-dimensional (3D)-printed individual template-guided 125 I seed implantation for the treatment of cervical lymph node metastasis. Materials and Methods: A total of 15 consecutive patients with cervical lymph node metastasis were enrolled during September 2015-July 2017 (12 patients had a history of external beam radiotherapy, with the mean dose of 63 Gy), who undergone radioactive seed implantation guided by the 3D-printed individual template...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29494598/18f-fluorodeoxyglucose-positron-emission-tomography-fdg-pet-radiomics-of-metastatic-lymph-nodes-and-primary-tumor-in-non-small-cell-lung-cancer-nsclc-a-prospective-externally-validated-study
#18
Sara Carvalho, Ralph T H Leijenaar, Esther G C Troost, Janna E van Timmeren, Cary Oberije, Wouter van Elmpt, Lioe-Fee de Geus-Oei, Johan Bussink, Philippe Lambin
BACKGROUND: Lymph node stage prior to treatment is strongly related to disease progression and poor prognosis in non-small cell lung cancer (NSCLC). However, few studies have investigated metabolic imaging features derived from pre-radiotherapy 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) of metastatic hilar/mediastinal lymph nodes (LNs). We hypothesized that these would provide complementary prognostic information to FDG-PET descriptors to only the primary tumor (tumor)...
2018: PloS One
https://www.readbyqxmd.com/read/29490633/effect-of-surgery-and-radiotherapy-on-complete-blood-count-lymphocyte-subsets-and-inflammatory-response-in-patients-with-advanced-oral-cancer
#19
Tadej Dovšak, Alojz Ihan, Vojko Didanovič, Andrej Kansky, Miha Verdenik, Nataša Ihan Hren
BACKGROUND: The immune system has a known role in the aetiology, progression and final treatment outcome of oral squamous cell cancers. The aim of this study was to evaluate the influence of radical surgery and radiotherapy on advanced oral squamous cell carcinoma blood counts, lymphocyte subsets and levels of acute inflammatory response markers. METHODS: Blood samples were obtained from 56 patients 5 days before and 10 days after surgery, 30 days and 1 year after radiotherapy...
March 1, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29470470/limiting-complication-rates-in-implant-based-breast-reconstruction
#20
Michelle B Locke, William LE Malins, Jia Le See, John Kenealy
BACKGROUND: External beam radiotherapy (XRT) to the breast has been shown to increase complication rates in women undergoing implant-based breast reconstruction (IBBR). Owing to concerns about high complication and failure rates, our department began to favour autologous reconstructive in patients requiring XRT in 2013. This study assesses the outcomes of IBBR prior to and following this policy change. METHODS: The records of all patients who underwent first-stage IBBR in 2012 and 2013 in our department were reviewed...
February 23, 2018: New Zealand Medical Journal
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