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pre-operative radiotherapy

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https://www.readbyqxmd.com/read/28437679/nodal-recurrence-after-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-incidence-and-proposed-risk-factors
#1
REVIEW
Krista C J Wink, Angela van Baardwijk, Esther G C Troost, Dirk De Ruysscher
Stereotactic body radiotherapy (SBRT) is an alternative to surgery for patients with early stage non-small cell lung cancer (NSCLC) who are inoperable due to comorbid disease or who refuse surgery. SBRT results in an excellent local control rate of more than 90%, which is comparable to surgery, while short and long-term overall toxicity is low. Surgically treated patients are often more extensively staged pre-operatively, e.g. with endobronchial ultrasound and/or mediastinoscopy, and typically undergo intra-operative lymph node dissection or sampling...
April 12, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28425130/histological-grading-based-on-poorly-differentiated-clusters-pdc-is-predictive-of-tumor-response-and-clinical-outcome-in-rectal-carcinoma-treated-with-neo-adjuvant-chemo-radiotherapy
#2
Luca Reggiani Bonetti, Simona Lionti, Federica Domati, Giuliana Pagliani, Elisabetta Mattioli, Valeria Barresi
AIMS: The clinical outcome of patients with locally advanced rectal cancer submitted to neo-adjuvant chemo-radiotherapy (CRT) is influenced by tumour response to treatment, which is reflected by tumour regression grade (TRG) and post-treatment (y) TNM stage. Little is known on the prognostic value of pre-treatment histopathological features of the tumour which may be useful to discriminate potential non-responders and to design tailored therapeutic strategies. In this study, we aimed to investigate the prognostic role of poorly differentiated clusters (PDC) of neoplastic cells in pre-treatment biopsies of rectal cancer submitted to neo-adjuvant CRT...
April 20, 2017: Histopathology
https://www.readbyqxmd.com/read/28422584/pre-and-post-prostatectomy-variables-associated-with-pelvic-post-operative-radiotherapy-in-prostate-cancer-patients-a-national-registry-based-study
#3
Kari Vatne, Andreas Stensvold, Tor Å Myklebust, Bjørn Møller, Aud Svindland, Rune Kvåle, Sophie D Fosså
BACKGROUND: In patients with prostate cancer (PCa), the lack of clear guidelines on the use of radiotherapy after radical prostatectomy (RP) invites unwanted variation of this treatment. We describe the hazard ratios and probabilities related to the use of post-RP radiotherapy. MATERIAL AND METHODS: Data were collected from the Cancer Registry of Norway and nine radiotherapy units. All patients were diagnosed with a non-metastatic PCa from January 2004 through June 2011...
April 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28422299/incorporation-of-pre-therapy-18-f-fdg-uptake-data-with-ct-texture-features-into-a-radiomics-model-for-radiation-pneumonitis-diagnosis
#4
Gregory J Anthony, Alexandra Cunliffe, Richard Castillo, Ngoc Pham, Thomas Guerrero, Samuel G Armato, Hania Al-Hallaq
PURPOSE: To determine whether the addition of standardized uptake value (SUV) from PET scans to CT lung texture features could improve a radiomics-based model of radiation pneumonitis (RP) diagnosis in patients undergoing radiotherapy. METHODS AND MATERIALS: Anonymized data from 96 esophageal cancer patients (18 RP-positive cases of Grade ≥ 2) were collected including pre-therapy PET/CT scans, pre-/post-therapy diagnostic CT scans and RP status. Twenty texture features (first-order, fractal, Laws' filter and gray-level co-occurrence matrix) were calculated from diagnostic CT scans and compared in anatomically matched regions of the lung...
April 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28377242/primary-spinal-cord-glioblastoma-multiforme-a-retrospective-study-of-patients-at-a-single-institution
#5
Xing Cheng, Silong Lou, Siqing Huang, M D Haifeng Chen, Jiagang Liu
[Background and objective] Primary spinal cord (PSC) glioblastoma multiforme GBM is extremely rare, which accounts for only 1.5% of all SC tumors. Therefore, its treatment is still ill defined. To elucidate prognostic factors, we performed a single-institutional retrospective review on the largest series to date of the patients with PSCGBM who underwent surgical resection in West China Hospital during the period between 2008 and 2014. A total of 14 PSCGBM patients were collected. [Method] Demographic, operative, and post-operative factors were recorded...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28370199/anterior-intercostal-artery-perforator-flap-in-immediate-breast-reconstruction-anatomical-study-and-clinical-application
#6
Cristian Carrasco-López, Juan Francisco Julian Ibañez, Jordi Vilà, Miguel Angel Luna Tomás, Jordi Navinés López, Iciar Pascual Miguel, Jaime Fernandez-Llamazares-Rodriguez, Carmen Higueras-Suñe
BACKGROUND: Although the use of lateral intercostal artery perforator (ICAP) flaps for immediate breast reconstruction has been widely described, data on the use of the anterior ICAP (AICAP) flaps for this indication are limited. In this context, we describe the results of anatomical study and our clinical experience with AICAP flaps for breast reconstruction. METHODS: In this study, the location and characteristics of the AICAPs were dissected in 12 female adult formalin-preserved hemitrunks and two fresh-frozen cadavers...
March 28, 2017: Microsurgery
https://www.readbyqxmd.com/read/28351504/changes-in-nationwide-use-of-preoperative-radiotherapy-for-rectal-cancer-after-revision-of-the-national-colorectal-cancer-guideline
#7
L Gietelink, M W J M Wouters, C A M Marijnen, J van Groningen, N van Leersum, R G H Beets-Tan, R A E M Tollenaar, P J Tanis
BACKGROUND: The rate of preoperative radiotherapy (RT) for rectal cancer in the Netherlands has been the highest among European countries. Revision of the national guideline on colorectal cancer, officially published in 2014, specifically focussed on the indication for RT and MRI criteria to evaluate mesorectal lymph nodes. The objective of this study was to evaluate implementation of the revised guideline using a national audit. METHODS: Data of the Dutch Surgical Colorectal Audit (DSCA) between 2009 and 2014 were used to evaluate RT use and RT regimen for relevant subgroups of cM0 rectal cancer patients, as well as accuracy of pre-operative MRI...
March 10, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28335886/neoscope-a-randomised-phase-ii-study-of-induction-chemotherapy-followed-by-oxaliplatin-capecitabine-or-carboplatin-paclitaxel-based-pre-operative-chemoradiation-for-resectable-oesophageal-adenocarcinoma
#8
Somnath Mukherjee, Christopher Nicholas Hurt, Sarah Gwynne, David Sebag-Montefiore, Ganesh Radhakrishna, Simon Gollins, Maria Hawkins, Heike I Grabsch, Gareth Jones, Stephen Falk, Ricky Sharma, Andrew Bateman, Rajarshi Roy, Ruby Ray, Jo Canham, Gareth Griffiths, Tim Maughan, Tom Crosby
BACKGROUND: Oxaliplatin-capecitabine (OxCap) and carboplatin-paclitaxel (CarPac) based neo-adjuvant chemoradiotherapy (nCRT) have shown promising activity in localised, resectable oesophageal cancer. PATIENTS AND METHODS: A non-blinded, randomised (1:1 via a centralised computer system), 'pick a winner' phase II trial. Patients with resectable oesophageal adenocarcinoma ≥ cT3 and/or ≥ cN1 were randomised to OxCapRT (oxaliplatin 85 mg/m(2) day 1, 15, 29; capecitabine 625 mg/m(2) bd on days of radiotherapy) or CarPacRT (carboplatin AUC2; paclitaxel 50 mg/m(2) day 1, 8, 15, 22, 29)...
March 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28332874/long-term-outcome-of-the-different-treatment-alternatives-for-recurrent-and-persistent-cushing-s-disease
#9
Ana Laura Espinosa-de-Los-Monteros, Ernesto Sosa-Eroza, Etual Espinosa, Victoria Mendoza, Rocio Arreola, Moises Mercado
BACKGROUND: Treatment alternatives for persistent and recurrent Cushing's disease (CD) include pituitary surgical reintervention, radiotherapy, pharmacotherapy and bilateral adrenalectomy (BA). The decision of which of these alternatives is better suited for the individual patient rests on clinical judgment and the availability of resources. OBJECTIVE: To evaluate the long-term efficacy of the different secondary interventions for persistent and recurrent Cushing's disease...
March 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28304143/anal-function-after-endoluminal-loco-regional-resection-by-transanal-endoscopic-microsurgery-and-radiotherapy-for-rectal-cancer
#10
Ivano Biviano, Andrea Balla, Danilo Badiali, Silvia Quaresima, Giancarlo D'Ambrosio, Emanuele Lezoche, Enrico Corazziari, Alessandro M Paganini
AIM: In patients with rectal cancer, surgery and chemo-radiotherapy may affect the anal sphincter function. Few studies evaluated the ano-rectal function after neoadjuvant chemo-radiotherapy (n-CRT) and/or Transanal Endoscopic Microsurgery (TEM). The aim of this study was to evaluate the effects of n-CRT and TEM on ano-rectal function. METHOD: Thirty-seven patients with rectal cancer underwent ano-rectal manometry and Wexner score for faecal incontinence at baseline, after n-CRT (cT2-T3N0 cancer) and at 4 and 12 months after surgery...
March 17, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28303058/-18f-fluorodeoxyglucose-uptake-by-positron-emission-tomography-predicts-outcomes-for-oropharyngeal-and-hypopharyngeal-cancer-treated-with-definitive-radiotherapy
#11
Takeaki Ishihara, Kazuhiro Kitajima, Yuko Suenaga, Yasuo Ejima, Hirokazu Komatsu, Naoki Otsuki, Ken-Ichi Nibu, Naomi Kiyota, Satoru Takahashi, Ryohei Sasaki
This study evaluated the prognostic significance of the maximum standardized uptake value of the primary site (pSUVmax) in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans of patients with oropharyngeal or hypopharyngeal cancer who were treated using definitive radiotherapy. The study included 86 patients who were primarily treated with radiotherapy for oropharyngeal or hypopharyngeal cancer. Sixty-nine patients underwent concurrent chemotherapy. The associations between pre-treatment pSUVmax and treatment outcomes were evaluated...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28267534/cross-sectional-imaging-to-evaluate-the-extent-of-regional-nodal-disease-in-breast-cancer-patients-undergoing-neoadjuvant-systemic-therapy
#12
Tara L Anderson, Katrina N Glazebrook, Brittany L Murphy, Lyndsay D Viers, Tina J Hieken
PURPOSE: Cross-sectional imaging often is performed in breast cancer patients undergoing neoadjuvant systemic therapy (NST) and may identify level III axillary and extra-axillary nodal disease. Our aim was to investigate associations of radiologic nodal staging with pathological N (pN) stage at operation and to explore how this might aid surgical and radiotherapy treatment planning. MATERIALS AND METHODS: With IRB approval, we reviewed pre-treatment breast MRI, PET/CT, and CT imaging and clinicopathologic data on 348 breast cancer patients with imaging available for review undergoing NST followed by operation at our institution 1/2008-9/2013...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28255734/robot-assisted-laparoscopic-transperitoneal-infrarenal-lymphadenectomy-in-patients-with-locally-advanced-cervical-cancer-by-single-docking-do-we-need-a-backup-procedure
#13
Fatih Gucer, Selim Misirlioglu, Nuri Ceydeli, Cagatay Taskiran
To present our initial experience on the feasibility of robotic transperitoneal para-aortic lymphadenectomy up to left renal vein via single docking approach by high port insertion technique followed by left shoulder docking as a rescue backup procedure in surgically obstructed patients undergoing surgical staging because of locally advanced cervical cancer (LACC). Prospective observational preliminary study. Canadian Task Force classification II-3. Tertiary-care academic affiliated private hospital. Ten patients with LACC who underwent robotic transperitoneal infrarenal para-aortic lymphadenectomy between January 2012 and December 2014...
March 2, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28237401/unraveling-biophysical-interactions-of-radiation-pneumonitis-in-non-small-cell-lung-cancer-via-bayesian-network-analysis
#14
Yi Luo, Issam El Naqa, Daniel L McShan, Dipankar Ray, Ines Lohse, Martha M Matuszak, Dawn Owen, Shruti Jolly, Theodore S Lawrence, Feng-Ming Spring Kong, Randall K Ten Haken
BACKGROUND: In non-small-cell lung cancer radiotherapy, radiation pneumonitis≥grade 2 (RP2) depends on patients' dosimetric, clinical, biological and genomic characteristics. METHODS: We developed a Bayesian network (BN) approach to explore its potential for interpreting biophysical signaling pathways influencing RP2 from a heterogeneous dataset including single nucleotide polymorphisms, micro RNAs, cytokines, clinical data, and radiation treatment plans before and during the course of radiotherapy...
April 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28197773/change-in-tongue-pressure-in-patients-with-head-and-neck-cancer-after-surgical-resection
#15
Yoko Hasegawa, Kazuma Sugahara, Tatsuyuki Fukuoka, Shota Saito, Ayumi Sakuramoto, Nobuhide Horii, Saori Sano, Kana Hasegawa, Yuta Nakao, Tomoki Nanto, Kanenori Kadoi, Kuniyasu Moridera, Kazuma Noguchi, Kazuhisa Domen, Hiromitsu Kishimoto
Tongue pressure is reportedly associated with dysphagia. This study investigated relationships among characteristics of head and neck cancer, tongue pressure and dysphagia screening tests performed in patients with head and neck cancer during the acute phase after surgical resection. Fifty-seven patients (36 men, 21 women; age range 26-95 years) underwent surgical resection and dysphagia screening tests (Repetitive Saliva Swallowing Test, Water Swallowing Test, Modified Water Swallowing Test and Food Test) and pre- and postoperative measurement of tongue pressure at 5 time points (preoperatively, and 1-2 weeks and 1, 2, and 3 months postoperatively)...
February 14, 2017: Odontology
https://www.readbyqxmd.com/read/28168421/screening-for-distress-using-the-distress-thermometer-and-the-university-of-washington-quality-of-life-in-post-treatment-head-and-neck-cancer-survivors
#16
Naseem Ghazali, Brenda Roe, Derek Lowe, Sank Tandon, Terry Jones, James Brown, Richard Shaw, Janet Risk, Simon N Rogers
The primary aim was to determine the efficacy of the Distress Thermometer (DT) in screening for anxiety and mood problems against the University of Washington Quality of Life, version 4 (UWQOL). Secondary aims were to evaluate the association between demographic, clinical and health-related QOL variables with significant distress. Two hundred and sixty one disease-free HNC ambulatory patients attending routine follow-up clinics were prospectively recruited. Both DT and UWQOL were completed pre-consultation...
February 6, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28162257/-intramedullary-astrocytomas-a-french-retrospective-multicenter-study
#17
F Parker, C Campello, J-P Lejeune, P David, A Herbrecht, N Aghakhani, M Messerer
AIM: The authors report the results of a multicenter retrospective series with a long-term follow-up and the analysis of clinical, radiological, surgical data as well as the complementary treatments in patients with intramedullary astrocytomas (IA). MATERIALS AND METHODS: We performed a retrospective analysis of all the patients with IA operated on between 1984 and 2011 at 7 French centers (Kremlin-Bicêtre, Lille, Lyon, Marseille, Montpellier, Nice, and Nîmes)...
February 2, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28126329/head-and-neck-target-delineation-using-a-novel-pet-automatic-segmentation-algorithm
#18
B Berthon, M Evans, C Marshall, N Palaniappan, N Cole, V Jayaprakasam, T Rackley, E Spezi
PURPOSE: To evaluate the feasibility and impact of using a novel advanced PET auto-segmentation method in Head and Neck (H&N) radiotherapy treatment (RT) planning. METHODS: ATLAAS, Automatic decision Tree-based Learning Algorithm for Advanced Segmentation, previously developed and validated on pre-clinical data, was applied to (18)F-FDG-PET/CT scans of 20 H&N patients undergoing Intensity Modulated Radiation Therapy. Primary Gross Tumour Volumes (GTVs) manually delineated on CT/MRI scans (GTVpCT/MRI), together with ATLAAS-generated contours (GTVpATLAAS) were used to derive the RT planning GTV (GTVpfinal)...
January 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28115491/development-and-external-validation-of-a-nomogram-and-online-tool-to-predict-bowel-dysfunction-following-restorative-rectal-cancer-resection-the-polars-score
#19
Nick J Battersby, George Bouliotis, Katrine J Emmertsen, Therese Juul, Rob Glynne-Jones, Graham Branagan, Peter Christensen, Søren Laurberg, Brendan J Moran
OBJECTIVE: Bowel dysfunction is common following a restorative rectal cancer resection, but symptom severity and the degree of quality of life impairment is highly variable. An internationally validated patient-reported outcome measure, Low Anterior Resection Syndrome (LARS) score, now enables these symptoms to be measured. The study purpose was: (1) to develop a model that predicts postoperative bowel function; (2) externally validate the model and (3) incorporate these findings into a nomogram and online tool in order to individualise patient counselling and aid preoperative consent...
January 23, 2017: Gut
https://www.readbyqxmd.com/read/28093890/long-term-follow-up-of-treatment-of-erectile-dysfunction-after-radical-prostatectomy-using-nerve-grafts-and-end-to-side-somatic-autonomic-neurorraphy-a-new-technique
#20
José Carlos Souza Trindade, Fausto Viterbo, André Petean Trindade, Wagner José Fávaro, José Carlos Souza Trindade-Filho
OBJECTIVE: To study a novel penile reinnervation technique using four sural nerve grafts and end-to-side neurorraphies connecting bilaterally the femoral nerve and the cavernous corpus and the femoral nerve and the dorsal penile nerves. PATIENTS AND METHODS: Ten patients (mean [± sd; range] age 60.3 [± 4.8; 54-68] years), who had undergone radical prostatectomy (RP) at least 2 years previously, underwent penile reinnervation in the present study. Four patients had undergone radiotherapy after RP...
January 17, 2017: BJU International
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