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https://www.readbyqxmd.com/read/28645153/defective-mitochondrial-rna-processing-due-to-pnpt1-variants-causes-leigh-syndrome
#1
Sanna Matilainen, Christopher J Carroll, Uwe Richter, Liliya Euro, Max Pohjanpelto, Anders Paetau, Pirjo Isohanni, Anu Suomalainen
Leigh syndrome is a severe infantile encephalopathy with an exceptionally variable genetic background. We studied the exome of a child manifesting with Leigh syndrome at one month of age and progressing to death by the age of 2.4 years, and identified novel compound heterozygous variants in PNPT1, encoding the polynucleotide phosphorylase (PNPase). Expression of the wild type PNPT1 in the subject's myoblasts functionally complemented the defects, and the pathogenicity was further supported by structural predictions and protein and RNA analyses...
June 22, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28645090/the-impact-of-tidal-and-mesoscale-eddy-advection-on-the-long-term-dispersion-of-99-tc-from-sellafield
#2
Magne Simonsen, Øyvind Saetra, Pål Erik Isachsen, Ole Christian Lind, Hilde Kristin Skjerdal, Brit Salbu, Hilde Elise Heldal, Justin P Gwynn
In the present work, numerical models are used to study the fate of the (99)Tc discharges from Sellafield with a specific focus on the role of mesoscale eddy and tidal advection on the transport and dispersion of this radionuclide. Transport estimates are made with an ocean model that resolves a large part of the ocean mesoscale eddy field and also includes tides. Equivalent estimates are also computed with another model in which these processes are either absent or parametrized. Comparison with field observations shows that the coarse-resolution model can reproduce the general features of the observed time-space (99)Tc distribution if the diffusivity in its eddy parametrization scheme is suitably chosen...
June 20, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28645016/quantitative-analysis-of-a-biopharmaceutical-protein-in-cell-culture-samples-using-automated-capillary-electrophoresis-ce-western-blot
#3
Dong Xu, Kentaro Marchionni, Yunli Hu, Wei Zhang, Zoran Sosic
An effective control strategy is critical to ensure the safety, purity and potency of biopharmaceuticals. Appropriate analytical tools are needed to realize such goals by providing information on product quality at an early stage to help understanding and control of the manufacturing process. In this work, a fully automated, multi-capillary instrument is utilized for size-based separation and western blot analysis to provide an early readout on product quality in order to enable a more consistent manufacturing process...
June 15, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28645015/mid-infrared-and-near-infrared-spectroscopy-for-rapid-detection-of-gardeniae-fructus-by-a-liquid-liquid-extraction-process
#4
Lingyan Tao, Zhonglin Lin, Jiashan Chen, Yongjiang Wu, Xuesong Liu
Gardeniae Fructus is widely used in the pharmaceutical industry, and many studies have confirmed its medical and economic value. In this study, samples collected from different liquid-liquid extraction batches of Gardeniae Fructus were detected by mid-infrared (MIR) and near-infrared (NIR) spectroscopy. Seven analytes, neochlorogenic acid (5-CQA), cryptochlorogenic acid (4-CQA), chlorogenic acid (3-CQA), geniposidic acid (GEA), deacetyl-asperulosidic acid methyl ester (DAAME), genipin-gentiobioside (GGB), and gardenoside (GA), were chosen as quality property indexes of Gardeniae Fructus...
June 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28644722/the-effects-of-polyvictimization-and-quality-of-caregiver-attachment-on-disclosure-of-illegal-sexual-behavior
#5
Megan E Harrelson, Apryl A Alexander, Hugo B Morais, Barry R Burkhart
The current study examined the relationship among self-disclosure of illegal sexual behaviors and two conceptually relevant constructs in psychotherapy: childhood polyvictimization (i.e., cumulative types of victimization experienced during childhood) and caregiver attachment. Participants consisted of 63 adolescent males participating in mandated treatment for illegal sexual behavior. Childhood polyvictimization and caregiver attachment were expected to predict self-disclosure of illegal sexual behaviors. Quality of caregiver attachment was also expected to mediate the relationship between polyvictimization and disclosure...
June 23, 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/28644664/radiation-pressure-cooling-as-a-quantum-dynamical-process
#6
Bing He, Liu Yang, Qing Lin, Min Xiao
One of the most fundamental problems in optomechanical cooling is how small the thermal phonon number of a mechanical oscillator can be achieved under the radiation pressure of a proper cavity field. Different from previous theoretical predictions, which were based on an optomechanical system's time-independent steady states, we treat such cooling as a dynamical process of driving the mechanical oscillator from its initial thermal state, due to its thermal equilibrium with the environment, to a stabilized quantum state of higher purity...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644616/importance-of-a-fully-anharmonic-treatment-of-equilibrium-isotope-fractionation-properties-of-dissolved-ionic-species-as-evidenced-by-li-aq
#7
Romain Dupuis, Magali Benoit, Mark E Tuckerman, Merlin Méheut
Equilibrium fractionation of stable isotopes is critically important in fields ranging from chemistry, including medicinal chemistry, electrochemistry, geochemistry, and nuclear chemistry, to environmental science. The dearth of reliable estimates of equilibrium fractionation factors, from experiment or from natural observations, has created a need for accurate computational approaches. Because isotope fractionation is a purely quantum mechanical phenomenon, exact calculation of fractionation factors is nontrivial...
June 23, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28644419/context-relevant-prediction-model-for-copd-domain-using-bayesian-belief-network
#8
Hamid Mcheick, Lokman Saleh, Hicham Ajami, Hafedh Mili
In the last three decades, researchers have examined extensively how context-aware systems can assist people, specifically those suffering from incurable diseases, to help them cope with their medical illness. Over the years, a huge number of studies on Chronic Obstructive Pulmonary Disease (COPD) have been published. However, how to derive relevant attributes and early detection of COPD exacerbations remains a challenge. In this research work, we will use an efficient algorithm to select relevant attributes where there is no proper approach in this domain...
June 23, 2017: Sensors
https://www.readbyqxmd.com/read/28643894/do-implicit-and-explicit-belief-processing-share-neural-substrates
#9
Claire K Naughtin, Kristina Horne, Dana Schneider, Dustin Venini, Ashley York, Paul E Dux
Humans rely on their ability to infer another person's mental state to understand and predict others' behavior ("theory of mind," ToM). Multiple lines of research suggest that not only are humans able to consciously process another person's belief state, but also are able to do so implicitly. Here we explored how general implicit belief states are represented in the brain, compared to those substrates involved in explicit ToM processes. Previous work on this topic has yielded conflicting results, and thus, the extent to which the implicit and explicit ToM systems draw on common neural bases is unclear...
June 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28643700/a-design-of-experiments-doe-approach-to-identify-the-influencing-parameters-that-determine-poly-d-l-lactic-acid-pdlla-electrospun-scaffold-morphologies
#10
Floor Agnes Andrea Ruiter, Cameron Alexander, Felicity Rose, Joel Segal
Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple, at the theoretical level the interactions between process parameters and their influence on the fibre morphology is not yet fully understood. Here, we hypothesised that a design of experiments (DoE) model could determine combinations of process parameters that result in significant effects on poly-D,L-lactic acid (PDLLA) fibre morphology...
June 23, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28642991/extensive-overlap-of-tropical-rainforest-bacterial-endophytes-between-soil-plant-parts-and-plant-species
#11
Emmanuel Haruna, Noraziah M Zin, Dorsaf Kerfahi, Jonathan M Adams
The extent to which distinct bacterial endophyte communities occur between different plant organs and species is poorly known and has implications for bioprospecting efforts. Using the V3 region of the bacterial 16S ribosomal RNA (rRNA) gene, we investigated the diversity patterns of bacterial endophyte communities of three rainforest plant species, comparing leaf, stem, and root endophytes plus rhizosphere soil community. There was extensive overlap in bacterial communities between plant organs, between replicate plants of the same species, between plant species, and between plant organ and rhizosphere soil, with no consistent clustering by compartment or host plant species...
June 22, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28642936/young-genes-are-highly-disordered-as-predicted-by-the-preadaptation-hypothesis-of-de-novo-gene-birth
#12
Benjamin A Wilson, Scott G Foy, Rafik Neme, Joanna Masel
The phenomenon of de novo gene birth from junk DNA is surprising, because random polypeptides are expected to be toxic. There are two conflicting views about how de novo gene birth is nevertheless possible: the continuum hypothesis invokes a gradual gene birth process, while the preadaptation hypothesis predicts that young genes will show extreme levels of gene-like traits. We show that intrinsic structural disorder conforms to the predictions of the preadaptation hypothesis and falsifies the continuum hypothesis, with all genes having higher levels than translated junk DNA, but young genes having the highest level of all...
June 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28642470/quantitative-proteomics-analysis-reveals-novel-targets-of-mir-21-in-zebrafish-embryos
#13
Ying Wu, Qi-Yong Lou, Feng Ge, Qian Xiong
MicroRNAs (miRNAs) are noncoding RNAs which control gene expression by the suppression of translation or the degradation of mRNAs. Dre-miR-21 (miR-21) has been reported to impact cardiac valvulogenesis in zebrafish embryos. However, the target genes of miR-21 are still largely unknown. Here a tandem isobaric mass tag (TMT)-based quantitative proteomic strategy was employed to identify the global profile of miR-21-regulated proteins. A total of 251 proteins were dysregulated after miR-21 knockdown, suggesting that they may be regulated by miR-21...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642333/patients-and-providers-perceptions-of-the-preventability-of-hospital-readmission-a-prospective-observational-study-in-four-european-countries
#14
Louise S van Galen, Mikkel Brabrand, Tim Cooksley, Peter M van de Ven, Hanneke Merten, Ralph Kl So, Loes van Hooff, Harm R Haak, Rachel M Kidney, Christian H Nickel, John Ty Soong, Immo Weichert, Mark Hh Kramer, Christian P Subbe, Prabath Wb Nanayakkara
OBJECTIVES: Because of fundamental differences in healthcare systems, US readmission data cannot be extrapolated to the European setting: To investigate the opinions of readmitted patients, their carers, nurses and physicians on predictability and preventability of readmissions and using majority consensus to determine contributing factors that could potentially foresee (preventable) readmissions. DESIGN: Prospective observational study. Readmitted patients, their carers, and treating professionals were surveyed during readmission to assess the discharge process and the predictability and preventability of the readmission...
June 22, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28641986/novel-spectrophotometric-technique-for-rapid-determination-of-extractable-pha-using-sudan-black-dye
#15
Mauricio A Porras, Marcelo A Villar, María A Cubitto
Classical techniques employed to determine the amount of extractable poly(hydroxyalkanoate)s (PHAs) from cells, are laborious and destructive. Sudan black staining is commonly used in the laboratory to investigate the presence of intracellular PHA. The aim of the present study was to develop a low-cost alternative technique to achieve a quick determination of extractable intracellular PHA. This methodology employs a basic laboratory spectroscopy equipment and Sudan black dye for spectra determination. The correlation between the content of PHA in cell samples taken directly from the culture flask and its spectra was determined using partial least square regression analysis and simple linear regression analysis...
June 19, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28641867/motivational-pathways-of-occupational-and-organizational-turnover-intention-among-newly-registered-nurses-in-canada
#16
Claude Fernet, Sarah-Geneviève Trépanier, Mireille Demers, Stéphanie Austin
BACKGROUND: Staff turnover is a major issue for health care systems. In a time of labor shortage, it is critical to understand the motivational factors that underlie turnover intention in newly licensed nurses. PURPOSE: To examine whether different forms of motivation (the reasons for which nurses engage in their work) predict intention to quit the occupation and organization through distinct forms (affective and continuance) and targets (occupation and organization) of commitment...
May 26, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28641812/continuum-based-models-and-concepts-for-the-transport-of-nanoparticles-in-saturated-porous-media-a-state-of-the-science-review
#17
REVIEW
Peyman Babakhani, Jonathan Bridge, Ruey-An Doong, Tanapon Phenrat
Environmental applications of nanoparticles (NP) increasingly result in widespread NP distribution within porous media where they are subject to various concurrent transport mechanisms including irreversible deposition, attachment/detachment (equilibrium or kinetic), agglomeration, physical straining, site-blocking, ripening, and size exclusion. Fundamental research in NP transport is typically conducted at small scale, and theoretical mechanistic modeling of particle transport in porous media faces challenges when considering the simultaneous effects of transport mechanisms...
June 7, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28641433/why-are-ggas-so-accurate-for-reaction-kinetics-on-surfaces-systematic-comparison-of-hybrid-vs-nonhybrid-dft-for-representative-reactions
#18
Andrew Mahler, Benjamin G Janesko, Salvador Moncho, Edward N Brothers
"Jacob's Ladder" of approximate exchange-correlation (XC) functionals in Kohn-Sham density functional theory are widely accepted to have systematic errors in reaction barriers. The first-rung local spin-density approximation (LDA) typically predicts barriers below generalized gradient approximations, which in turn predict barriers below experiment and below fourth-rung hybrid functionals incorporating a fraction of exact exchange. We show that several reactions from previous literature reports, as well as new simulations of carbon-carbon coupling in the Fischer-Tropsch process, do not follow this conventional picture...
June 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28641262/scalable-multi-view-semi-supervised-classification-via-adaptive-regression
#19
Hong Tao, Chenping Hou, Feiping Nie, Jubo Zhu, Dongyun Yi
With the advent of multi-view data, multi-view learning has become an important research direction in machine learning and image processing. Considering the difficulty of obtaining labeled data in many machine learning applications, we focus on the multi-view semi-supervised classification problem. In this paper, we propose an algorithm named Multi-View Semi-Supervised Classification via Adaptive Regression (MVAR) to address this problem. Specifically, regression based loss functions with ℓ2,1 matrix norm are adopted for each view and the final objective function is formulated as the linear weighted combination of all the loss functions...
June 19, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28641189/qualitative-and-quantitative-simulation-of-androgen-receptor-antagonists-a-case-study-of-polybrominated-diphenyl-ethers
#20
Yang Wu, Wei Shi, Pu Xia, Xiaowei Zhang, Hongxia Yu
Recently, great attention has been paid to the identification and prediction of the androgen disrupting potencies of polybrominated diphenyl ethers (PBDEs). However, few existing models can discriminate active and inactive compounds, which make the quantitative prediction process including the quantitative structure-activity relationship (QSAR) technique unreliable. In this study, different grouping methods were investigated and compared for qualitative identification, including molecular docking and molecular dynamics simulations (MD)...
June 19, 2017: Science of the Total Environment
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