Read by QxMD icon Read

Predictive processing

Soosan Abdollahi, Mohammad Hossein Ghahremani, Neda Setayesh, Nasrin Samadi
The Lactococcus lactis is known as a probiotic bacterium and also as a producer of nisin. Nisin has been approved by related legal agencies to be used as an antimicrobial peptide in food preservation. In fact, the L. lactis is present in different food products along with other micro-organisms especially pathogenic bacteria. So, it is important to predict the behavior of nisin-producer strain in contact with other pathogens. In this regard, nisin gene expression and the level of secreted biologically active form of nisin by L...
June 13, 2018: Microbial Pathogenesis
Ákos Kovács, Dániel Dudola, László Nyitray, Gábor Tóth, Zoltán Nagy, Zoltán Gáspári
Single alpha-helices (SAHs) are increasingly recognized as important structural and functional elements of proteins. Comprehensive identification of SAH segments in large protein datasets was largely hindered by the slow speed of the most restrictive prediction tool for their identification, FT_CHARGE on common hardware. We have previously implemented an FPGA-based version of this tool allowing fast analysis of a large number of sequences. Using this implementation, we have set up of a semi-automated pipeline capable of analyzing full UniProt releases in reasonable time and compiling monthly updates of a comprehensive database of SAH segments...
June 13, 2018: Journal of Structural Biology
Abdallah R Ismail, Samy B El-Henawy, Sherif A Younis, Mohamed A Betiha, Nour Sh El-Gendy, Mohamed S Azab, Nagwa M Sedky
THE AIM: of this study was to isolate and identify lipolytic bacteria. Perform a statistical stepwise physicochemical optimization for maximum production of extracellular lipase and its validation in a bioreactor. METHODS AND RESULTS: Several lipolytic bacteria were isolated from petroleum hydrocarbon polluted soil. The strain expressing the highest lipase activity (47 U ml-1 ) was genetically identified as Gram +ve Bacillus stratosphericus PSP8 (NCBI GenBank Accession no...
June 16, 2018: Journal of Applied Microbiology
Michael Kossmeier, Georg Heinze
MAIN PROBLEM: Citations are widely used for measuring scientific impact. The goal of the present study is to predict citation counts of manuscripts submitted to Transplant International (TI) in the two calendar years following publication. METHODS: We considered a comprehensive set of 21 manuscript, author, and peer review related predictor variables available early in the peer review process. We also evaluated how successfully the peer-review process at TI identified and accepted the most promising manuscripts for publication...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Sonia Singh, Anne M Walk, Christopher M Conway
Previous research suggests that individuals with developmental dyslexia perform below typical readers on non-linguistic cognitive tasks involving the learning and encoding of statistical-sequential patterns. However, the neural mechanisms underlying such a deficit have not been well examined. The aim of the present study was to investigate the event-related potential (ERP) correlates of sequence processing in a sample of children diagnosed with dyslexia using a non-linguistic visual statistical learning paradigm...
June 15, 2018: Annals of Dyslexia
Jan Willem Bruggeman, Jan Koster, Paul Lodder, Sjoerd Repping, Geert Hamer
Cancer cells have been found to frequently express genes that are normally restricted to the testis, often referred to as cancer/testis (CT) antigens or genes. Because germ cell-specific antigens are not recognized as "self" by the innate immune system, CT-genes have previously been suggested as ideal candidate targets for cancer therapy. The use of CT-genes in cancer therapy has thus far been unsuccessful, most likely because their identification has relied on gene expression in whole testis, including the testicular somatic cells, precluding the detection of true germ cell-specific genes...
June 15, 2018: Oncogene
Marta Vazquez-Vilar, Diego Orzaez, Nicola Patron
Synthetic Biology is defined as the application of engineering principles to biology. It aims to increase the speed, ease and predictability with which desirable changes and novel traits can be conferred to living cells. The initial steps in this process aim to simplify the encoding of new instructions in DNA by establishing low-level programming languages for biology. Together with advances in the laboratory that allow multiple DNA molecules to be efficiently assembled together into a desired order in a single step, this approach has simplified the design and assembly of multigene constructs and has even facilitated the automated construction of synthetic chromosomes...
August 2018: Plant Science: An International Journal of Experimental Plant Biology
Madana M R Ambavaram, Aminat Ali, Kieran P Ryan, Oliver Peoples, Kristi D Snell, Maria N Somleva
Increasing crop yield requires the coordination of multiple metabolic pathways spanning photosynthetic carbon fixation, central carbon metabolism, and finally targeted carbon deposition to end product. In this study, we used a transcriptome-based gene regulatory association network to search for transcription factor genes that could play a role in increasing carbon flow through pathways associated with these processes to increase biomass yield in switchgrass. Two novel switchgrass transcription factors, PvBMY1 (BioMass Yield 1, belonging to the APETALA2/Ethylene Response Factor family of transcription factors) and PvBMY3 (BioMass Yield 3, a member of the Nuclear-Factor Y family of transcription factors), with predicted roles in the regulation of photosynthesis and related metabolism were identified...
August 2018: Plant Science: An International Journal of Experimental Plant Biology
Ciro Andolfi, Gyorgy Baffy, P Marco Fisichella
In the past decade, the introduction of high-resolution manometry and the classification of achalasia into subtypes has made possible to accurately diagnose the disease and predict the response to treatment for its different subtypes. However, even to date, in an era of exponential medical progress and increased insight in disease mechanisms, treatment of patients with achalasia is still rather simplistic and mostly confined to mechanical disruption of the lower esophageal sphincter by different means. In addition, there is partial consensus on what is the best form of available treatments for patients with achalasia...
August 2018: Journal of Surgical Research
Subhadeep Roy
The present paper deals with a fiber bundle model which consists of a fraction α of infinitely strong fibers. The inclusion of such an unbreakable fraction has been proven to affect the failure process in early studies, especially around a critical value α_{c}. The present work has a twofold purpose: (i) a study of failure abruptness, mainly the brittle to quasibrittle transition point with varying α and (ii) variation of α_{c} as we change the strength of disorder introduced in the model. The brittle to quasibrittle transition is confirmed from the failure abruptness...
May 2018: Physical Review. E
Alexandr Malijevský
We consider condensation in a capillary groove of width L and depth D, formed by walls that are completely wet (contact angle θ=0), which is in a contact with a gas reservoir of the chemical potential μ. On a mesoscopic level, the condensation process can be described in terms of the midpoint height ℓ of a meniscus formed at the liquid-gas interface. For macroscopically deep grooves (D→∞), and in the presence of long-range (dispersion) forces, the condensation corresponds to a second-order phase transition, such that ℓ∼(μ_{cc}-μ)^{-1/4} as μ→μ_{cc}^{-} where μ_{cc} is the chemical potential pertinent to capillary condensation in a slit pore of width L...
May 2018: Physical Review. E
Shou-Wen Wang
The Harada-Sasa equality elegantly connects the energy dissipation rate of a moving object with its measurable violation of the Fluctuation-Dissipation Theorem (FDT). Although proven for Langevin processes, its validity remains unclear for discrete Markov systems whose forward and backward transition rates respond asymmetrically to external perturbation. A typical example is a motor protein called kinesin. Here we show generally that the FDT violation persists surprisingly in the high-frequency limit due to the asymmetry, resulting in a divergent FDT violation integral and thus a complete breakdown of the Harada-Sasa equality...
May 2018: Physical Review. E
A Böbel, C A Knapek, C Räth
Experiments of the recrystallization processes in two-dimensional complex plasmas are analyzed to rigorously test a recently developed scale-free phase transition theory. The "fractal-domain-structure" (FDS) theory is based on the kinetic theory of Frenkel. It assumes the formation of homogeneous domains, separated by defect lines, during crystallization and a fractal relationship between domain area and boundary length. For the defect number fraction and system energy a scale-free power-law relation is predicted...
May 2018: Physical Review. E
Hongshun Xing, Shilei Wang, Quancai Li, Yongqian Ma, Peng Sun
Emerging evidence reveal that long noncoding RNAs (lncRNAs) participates in the epigenetic regulation of pathophysiological process. However, the deepgoing role of lncRNAs on meningioma is still unclear. In present study, we investigate the roles of lncRNA LINC00460 in meningeoma tissue and uncover its molecular mechanism. Results revealed that LINC00460 expression level was significantly up-regulated in meningeoma tissues and malignant meningeoma cell lines (IOMM-Lee, CH157-MN). Mechanically, loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Birgitte Bruun Rasmussen, Eva Balslev, Ib Jarle Christensen, Charlotte Lanng, Anne Bak, Hanne Galatius, Maj-Lis Møller Talman, Nahid Sharghi Someh, Ilse Vejborg, Mette Okholm
Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation...
May 22, 2018: Breast: Official Journal of the European Society of Mastology
Anja Vaskinn, Stein Andersson, Tiril Østefjells, Ole A Andreassen, Kjetil Sundet
BACKGROUND: Theory of mind (ToM) can be divided into cognitive and affective ToM, and a distinction can be made between overmentalizing and undermentalizing errors. Research has shown that ToM in schizophrenia is associated with non-social and social cognition, and with clinical symptoms. In this study, we investigate cognitive and clinical predictors of different ToM processes. METHODS: Ninety-one individuals with schizophrenia participated. ToM was measured with the Movie for the Assessment of Social Cognition (MASC) yielding six scores (total ToM, cognitive ToM, affective ToM, overmentalizing errors, undermentalizing errors and no mentalizing errors)...
June 5, 2018: Comprehensive Psychiatry
Marina R Pulido, Verónica González-Galán, Felipe Fernández Cuenca, Álvaro Pascual, José Garnacho-Montero, Massimo Antonelli, George Dimopoulos, José A Lepe, Michael J McConnell, José Miguel Cisneros
OBJECTIVE: The objective of this study was to evaluate the ability of the BioFire FilmArray Blood Culture Identification (BCID) Panel to rapidly detect pathogens producing late-onset ventilator-associated pneumonia (VAP), a severe infection often produced by Gram negative bacteria. These microorganisms are frequently multidrug resistant (MDR) and typically require broad spectrum empiric treatment. METHODS: In this study, in the context of an international multicenter clinical trial (Magic Bullet), respiratory samples were collected at the time of suspicion of VAP from 165 patients in 32 participating hospitals in Spain, Greece and Italy...
June 12, 2018: Clinical Microbiology and Infection
Emma M Harding-Esch, Sebastian S Fuller, S-L Christine Chow, Achyuta V Nori, Mark A Harrison, Mathew Parker, Olaf Piepenburg, Matthew S Forrest, David G Brooks, Rajul Patel, Phillip Hay, Nicola Fearnley, Marcus J Pond, J Kevin Dunbar, Philip D Butcher, Timothy Planche, Catherine M Lowndes, S Tariq Sadiq
OBJECTIVES: Rapid and accurate sexually transmitted infection diagnosis can reduce onward transmission and improve treatment efficacy. We evaluated the accuracy of a 15-minute run-time recombinase polymerase amplification (RPA)-based prototype point-of-care test (TwistDx) for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). METHODS: Prospective, multi-centre study of symptomatic and asymptomatic patients attending three English sexual health clinics. Research samples provided were: additional self-collected vulvo-vaginal swab (SCVS) (females); first-catch urine (FCU) aliquot (females and males)...
June 12, 2018: Clinical Microbiology and Infection
Sheue-Fen Tzeng, Chin-Hsien Tsai, Tai-Kuang Chao, Yu-Ching Chou, Yu-Chih Yang, Mong-Hsun Tsai, Tai-Lung Cha, Pei-Wen Hsiao
Disseminated castration-resistant prostate cancer (CRPC) is a common disease in men that is characterized by limited survival and resistance to androgen-deprivation therapy. The increase in human epidermal growth factor receptor 2 (HER2) signaling contributes to androgen receptor activity in a subset of patients with CRPC; however, enigmatically, HER2-targeted therapies have demonstrated a lack of efficacy in patients with CRPC. Aberrant glycosylation is a hallmark of cancer and involves key processes that support cancer progression...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
F A Spitznagel, J Boldt, P C Gierthmuehlen
Advances in computer-aided design (CAD) / computer-aided manufacturing (CAM) technologies and their ease of application enabled the development of novel treatment concepts for modern prosthodontics. This recent paradigm shift in fixed prosthodontics from traditional to minimally invasive treatment approaches is evidenced by the clinical long-term success of bonded CAD/CAM glass-ceramic restorations. Today, defect-oriented restorations, such as inlays, onlays, and posterior crowns, are predominately fabricated from glass-ceramics in monolithic application...
June 1, 2018: Journal of Dental Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"