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carotid wall stress

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https://www.readbyqxmd.com/read/29768378/cerebral-infarction-as-initial-presentation-in-stress-cardiomyopathy-case-report-and-literature-review
#1
Qiongying Wang, Heng Yu, Cheng Jiang, Runmin Sun, Miaomiao Qi, Shougang Sun, Guangli Xu, Hongbin Cai, Zhenchang Zhang, Feng Zhao, Xiaoqing Kou, Jing Yu, Feng Bai
RATIONALE: The typical symptoms of stress cardiomyopathy include sudden-onset chest pain and breathlessness or collapse as well as classical symptoms of cardiovascular disease; however, rare reports have described nervous system symptoms as the initial manifestation. Here, we report the case of a young man who presented with a large cerebral infarction as the main clinical symptom of stress cardiomyopathy to increase recognition of the disease. PATIENT CONCERNS: A 28-year-old man was admitted to our hospital for sudden-onset weakness of the right limbs and unconsciousness for 1 day...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29731721/endothelial-aip1-regulates-vascular-remodeling-by-suppressing-nadph-oxidase-2
#2
Jiqin Zhang, Chaofei Chen, Li Li, Huanjiao J Zhou, Fenghe Li, Haifeng Zhang, Luyang Yu, Yuxin Chen, Wang Min
Objective: AIP1 expression is downregulated in human atherosclerotic plaques and global deletion of AIP1 in mice exacerbates atherosclerosis in ApoE-KO mouse models. However, the direct role of AIP1 in endothelium, vascular remodeling and associated vascular diseases has not been determined. Approach and Results: We used endothelial cell (EC)-specific AIP1-deficient (AIP1-ECKO) mice to define the role of AIP1 in vascular remodeling and intima-media thickening in a mouse carotid artery ligation model characterized by both neointimal hyperplasia and inward vessel remodeling...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29726778/hemodynamic-characteristics-associated-with-cerebral-aneurysm-formation-in-patients-with-carotid-occlusion
#3
Sophia F Shakur, Ali Alaraj, Nasya Mendoza-Elias, Muhammad Osama, Fady T Charbel
OBJECTIVE The pathogenesis of cerebral aneurysms in patients with internal carotid artery (ICA) occlusion is hypothesized to be hemodynamic. For the first time, the authors quantify the hemodynamic characteristics associated with aneurysm formation in patients with ICA occlusion. METHODS Records of patients with unilateral ICA stenosis or occlusion ≥ 90% who underwent hemodynamic assessment before treatment using quantitative MR angiography were retrospectively reviewed. The patients were classified into 2 groups based on the presence or absence of aneurysms...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#4
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29678322/measurement-of-wall-shear-stress-exerted-by-flowing-blood-in-the-human-carotid-artery-ultrasound-doppler-velocimetry-and-echo-particle-image-velocimetry
#5
Phillip E Gates, Arati Gurung, Luciano Mazzaro, Kuni Aizawa, Salim Elyas, William D Strain, Angela C Shore, Robin Shandas
Vascular endothelial cells lining the arteries are sensitive to wall shear stress (WSS) exerted by flowing blood. An important component of the pathophysiology of vascular diseases, WSS is commonly estimated by centerline ultrasound Doppler velocimetry (UDV). However, the accuracy of this method is uncertain. We have previously validated the use of a novel, ultrasound-based, particle image velocimetry technique (echo PIV) to compute 2-D velocity vector fields, which can easily be converted into WSS data. We compared WSS data derived from UDV and echo PIV in the common carotid artery of 27 healthy participants...
April 17, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29657758/temporal-and-spatial-changes-in-wall-shear-stress-during-atherosclerotic-plaque-progression-in-mice
#6
R Xing, A M Moerman, Y Ridwan, M J Daemen, A F W van der Steen, F J H Gijsen, K van der Heiden
Wall shear stress (WSS) is involved in atherosclerotic plaque initiation, yet its role in plaque progression remains unclear. We aimed to study (i) the temporal and spatial changes in WSS over a growing plaque and (ii) the correlation between WSS and plaque composition, using animal-specific data in an atherosclerotic mouse model. Tapered casts were placed around the right common carotid arteries (RCCA) of ApoE-/- mice. At 5, 7 and 9 weeks after cast placement, RCCA geometry was reconstructed using contrast-enhanced micro-CT...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29615730/retrospective-study-of-hemodynamic-changes-before-and-after-carotid-stenosis-formation-by-vessel-surface-repairing
#7
Xiao Li, Beibei Sun, Huilin Zhao, Xiaoqian Ge, Fuyou Liang, Xuanyu Li, Jianrong Xu, Xiaosheng Liu
Prospective observation of hemodynamic changes before and after the formation of atherosclerotic stenosis in the carotid artery is difficult. Thus, a vessel surface repairing method was used for retrospective hemodynamic study before and after atherosclerotic stenosis formation in carotid artery. The three-dimensional geometry of sixteen sinus atherosclerotic stenosis carotid arteries were repaired and restored as normal arteries. Computational fluid dynamics analysis was performed to estimate wall shear stress (WSS), velocity and vortex in atherosclerosis-free areas and sinus in stenosis-repaired carotid artery...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29602477/flow-instability-detected-in-ruptured-versus-unruptured-cerebral-aneurysms-at-the-internal-carotid-artery
#8
Lijian Xu, Fuyou Liang, Lixu Gu, Hao Liu
Flow instability has emerged as a new hemodynamic metric hypothesized to have potential value in assessing the rupture risk of cerebral aneurysms. However, diverse findings have been reported in the literature. In the present study, high-resolution hemodynamic simulations were performed retrospectively on 35 aneurysms (10 ruptured & 25 unruptured) located at the internal carotid artery (ICA). Simulated hemodynamic parameters were statistically compared between the ruptured and unruptured aneurysms, with emphasis on examining the correlation of flow instability with the status of aneurysm rupture...
March 15, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29580793/comparison-of-in-vivo-vs-ex-situ-obtained-material-properties-of-sheep-common-carotid-artery
#9
Marija Smoljkić, Peter Verbrugghe, Matilda Larsson, Erik Widman, Heleen Fehervary, Jan D'hooge, Jos Vander Sloten, Nele Famaey
Patient-specific biomechanical modelling can improve preoperative surgical planning. This requires patient-specific geometry as well as patient-specific material properties as input. The latter are, however, still quite challenging to estimate in vivo. This study focuses on the estimation of the mechanical properties of the arterial wall. Firstly, in vivo pressure, diameter and thickness of the arterial wall were acquired for sheep common carotid arteries. Next, the animals were sacrificed and the tissue was stored for mechanical testing...
March 23, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29579672/induction-of-extracranial-arteriogenesis-by-an-arteriovenous-fistula-in-a-pig-model
#10
Eva Elina Buschmann, Eun-Ji Lee, Dorit Jacobi, Anne-Katrin Woischnig, Susann Ulusans, Martin Schumacher, Katherine H Smith, Nikolaos Pagonas, Peter Bramlage, Joachim Klisch, Philipp Hillmeister, Ivo R Buschmann
BACKGROUND AND AIMS: Arteriogenesis, the positive outward remodeling and growth of pre-existent collateral vessels, holds potential as a novel treatment for ischemic vascular disease. An extracranial arteriogenesis model in a pig will allow us to study molecular changes in a complex arteriolar network in a more clinically relevant large-animal model. To increase fluid shear stress in the brain, an experimental carotid arteriovenous fistula (AVF model) in minipigs was established, providing high flow through the extracranial rete mirabile...
March 3, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29566209/high-pressure-in-virtual-postcoiling-model-is-a-predictor-of-internal-carotid-artery-aneurysm-recurrence-after-coiling
#11
Iku Nambu, Kouichi Misaki, Naoyuki Uchiyama, Masanao Mohri, Takashi Suzuki, Hiroyuki Takao, Yuichi Murayama, Kazuya Futami, Tomoki Kawamura, Yasushi Inoguchi, Teruo Matsuzawa, Mitsutoshi Nakada
BACKGROUND: Hemodynamic factors play a crucial role in the recurrence of intracranial aneurysms after coiling. However, the strongest factor for predicting recurrence remains unclear because each risk factor has been investigated and reported separately. OBJECTIVE: To clarify the strongest predictor of recurrence with computational fluid dynamics (CFD). METHODS: Using pretreatment patient-specific 3-dimensional rotational angiography data of 50 internal carotid artery (ICA) aneurysms (7 recanalized, 43 stable) treated with endovascular coiling, we created a precoiling model and a virtual postcoiling model produced by manually cutting the aneurysm by the flat plane corresponding to the virtual coil surface...
March 15, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29552030/vascular-remodeling-oxidative-stress-and-disrupted-ppar-%C3%AE-expression-in-rats-of-long-term-hyperhomocysteinemia-with-metabolic-disturbance
#12
Yajing Huo, Xuqing Wu, Jing Ding, Yang Geng, Weiwei Qiao, Anyan Ge, Cen Guo, Jianing Lv, Haifeng Bao, Wei Fan
Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome. Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. We also studied oxidative stress and expression of PPAR γ in the coronary arteriole as a possible mechanism underlying vascular remodeling. Rats were treated with standard rodent chow (Control) or diet enriched in methionine (Met) for 48 weeks. Plasma homocysteine, blood glucose, serum lipids, malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) levels were measured...
2018: PPAR Research
https://www.readbyqxmd.com/read/29541422/low-carotid-wall-shear-stress-independently-accelerates-the-progression-of-cognitive-impairment-and-white-matter-lesions-in-the-elderly
#13
Hua Zhang, Hongxia Liu, Yuanli Dong, Juan Wang, Yingxin Zhao, Yi Cui, Qiang Chai, Zhendong Liu
The association of hemodynamics with cognitive impairment and white matter lesions (WMLs) has come to the foreground in recent years. Six hundred eighty-nine elderly participants aged ≥60 years were eligible enrolled. After an average of 5.4 years follow-up, there was a significant decline in Mini-Mental State Examination (MMSE) scores and increases in total white matter hyperintensities (WMH), periventricular (P)WMH, and deep (D)WMH ( P < 0.001). The participants were grouped by the tertiles of carotid mean wall shear stress (WSS)...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29520642/hemodynamic-vascular-biomarkers-for-initiation-of-paraclinoid-internal-carotid-artery-aneurysms-using-patient-specific-computational-fluid-dynamic-simulation-based-on-magnetic-resonance-imaging
#14
Tomoya Watanabe, Haruo Isoda, Yasuo Takehara, Masaki Terada, Takehiro Naito, Takafumi Kosugi, Yuki Onishi, Chiharu Tanoi, Takashi Izumi
PURPOSE: We performed computational fluid dynamics (CFD) for patients with and without paraclinoid internal carotid artery (ICA) aneurysms to evaluate the distribution of vascular biomarkers at the aneurysm initiation sites of the paraclinoid ICA. METHODS: This study included 35 patients who were followed up for aneurysms using 3D time of flight (TOF) magnetic resonance angiography (MRA) and 3D cine phase-contrast MR imaging. Fifteen affected ICAs were included in group A with the 15 unaffected contralateral ICAs in group B...
May 2018: Neuroradiology
https://www.readbyqxmd.com/read/29503774/patient-specific-flow-descriptors-and-normalized-wall-index-in-peripheral-artery-disease-a-preliminary-study
#15
Jaykrishna Singh, Gerd Brunner, Joel D Morrisett, Christie M Ballantyne, Alan B Lumsden, Dipan J Shah, Paolo Decuzzi
Background and Aims: MRI-based hemodynamics have been applied to study the relationship between time-averaged wall shear stresses (TAWSS), oscillatory shear index (OSI) and atherosclerotic lesions in the coronary arteries, carotid artery, and human aorta. However, the role of TAWSS and OSI are poorly understood in lower extremity arteries. The aim of this work was to investigate the feasibility of hemodynamic assessment of the superficial femoral artery (SFA) in patients with peripheral artery disease (PAD) and we hypothesized that there is an association between TAWSS and OSI, respectively, and atherosclerotic burden expressed as the normalized wall index (NWI)...
2018: Computer Methods in Biomechanics and Biomedical Engineering. Imaging & Visualization
https://www.readbyqxmd.com/read/29501904/distinct-vascular-remodeling-pattern-of-adult-rats-with-carotid-jugular-shunt
#16
Ping Lü, Qibin Jiao, Daisuke Shimura, Yoichiro Kusakari, Fang Liu, Susumu Minamisawa
BACKGROUND: Previous research has revealed that patent vein grafts lose their venous identity Eph-B4 but do not gain arterial identity ephrin-B2 during adaptation to the arterial circulation, and vascular identity marker, for example, the Eph-B4 signaling is a critical determinant of venous wall thickness of vein grafts. But what is the remodeling pattern, especially the remodeling pattern of vascular identity in the venous segment of arteriovenous shunt at a late stage postoperation has not been fully explored...
May 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29499760/influence-of-vascular-geometry-on-local-hemodynamic-parameters-phantom-and-small-rodent-study
#17
Lili Niu, Xiliang Zhu, Min Pan, Abbott Derek, Lisheng Xu, Long Meng, Hairong Zheng
BACKGROUND: Many studies have demonstrated that the geometry of the carotid bifurcation enables prediction of blood flow variation associated with atherosclerotic plaque formation. The phase angle between the arterial wall circumferential strain and its instantaneous wall shear stress is known as stress phase angle (SPA). This parameter is used to evaluate hemodynamic factors of atherogenesis. Note that SPA can be numerically computed for the purpose of locating atherosclerosis in different artery geometries...
March 2, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29470857/numerical-study-on-the-hemodynamics-of-patient-specific-carotid-bifurcation-using-a-new-mesh-approach
#18
S I S Pinto, J B L M Campos, E Azevedo, C F Castro, L C Sousa
The definition of a suitable mesh to simulate blood flow in the human carotid bifurcation has been investigated. In this research, a novel mesh generation method is proposed: hexahedral cells at the center of the vessel and a fine grid of tetrahedral cells near the artery wall, in order to correctly simulate the large blood velocity gradients associated with specific locations. The selected numerical examples to show the pertinence of the novel generation method are supported by carotid ultrasound image data of a patient-specific case...
February 22, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29446991/fluid-structure-interaction-modeling-of-aneurysmal-arteries-under-steady-state-and-pulsatile-blood-flow-a-stability-analysis
#19
Mohammadali Sharzehee, Seyed Saeid Khalafvand, Hai-Chao Han
Tortuous aneurysmal arteries are often associated with a higher risk of rupture but the mechanism remains unclear. The goal of this study was to analyze the buckling and post-buckling behaviors of aneurysmal arteries under pulsatile flow. To accomplish this goal, we analyzed the buckling behavior of model carotid and abdominal aorta with aneurysms by utilizing fluid-structure interaction (FSI) method with realistic waveforms boundary conditions. FSI simulations were done under steady-state and pulsatile flow for normal (1...
February 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29444617/hemodynamic-impingement-and-the-initiation-of-intracranial-side-wall-aneurysms
#20
Gerald J Riccardello, Abhinav R Changa, Fawaz Al-Mufti, I Paul Singh, Chirag Gandhi, Max Roman, Charles J Prestigiacomo
Objective The natural history intracranial aneurysms (IA) remains poorly understood despite significant morbidity and mortality associated with IA rupture. Hemodynamic impingement resulting in elevations in wall shear stress and wall shear stress gradient (WSSG) has been shown to induce aneurysmal remodeling at arterial bifurcations. We investigate the hemodynamic environment specific to side-wall pre-aneurysmal vasculature. We hypothesize that fluid impingement and secondary flow patterns play a role in side-wall aneurysm initiation...
January 1, 2018: Interventional Neuroradiology
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