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carotid wall stress

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https://www.readbyqxmd.com/read/28273662/dedifferentiated-fat-cells-as-a-novel-source-for-cell-therapy-to-target-neonatal-hypoxic-ischemic-encephalopathy
#1
Alkisti Mikrogeorgiou, Yoshiaki Sato, Taiki Kondo, Tetsuo Hattori, Yuichiro Sugiyama, Miharu Ito, Akiko Saito, Keiko Nakanishi, Masahiro Tsuji, Tomohiko Kazama, Koichiro Kano, Taro Matsumoto, Masahiro Hayakawa
Neonatal hypoxic-ischemic (HI) encephalopathy (HIE) remains a major cause of mortality and persistent neurological disabilities in affected individuals. At present, hypothermia is considered to be the only applicable treatment option, although growing evidence suggests that cell-based therapy might achieve better outcomes. Dedifferentiated fat (DFAT) cells are derived from mature adipocytes via a dedifferentiation strategy called ceiling culture. Their abundance and ready availability might make them an ideal therapeutic tool for the treatment of HIE...
March 9, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28223475/reduced-first-phase-ejection-fraction-and-sustained-myocardial-wall-stress-in-hypertensive-patients-with-diastolic-dysfunction-a-manifestation-of-impaired-shortening-deactivation-that-links-systolic-to-diastolic-dysfunction-and-preserves-systolic-ejection-fraction
#2
Haotian Gu, Ye Li, Henry Fok, John Simpson, Jonathan C Kentish, Ajay M Shah, Philip J Chowienczyk
Impaired shortening deactivation of cardiac myocytes could sustain myocardial contraction, preserving ejection fraction at the expense of diastolic dysfunction. We examined the relationship between first-phase ejection fraction (EF1), the fraction of left ventricular volume ejected from the start of systole to the time of the first peak in left ventricular pressure (corresponding to the time of maximal ventricular shortening) to the duration of myocardial contraction and diastolic function in patients with hypertension (n=163), and varying degrees of diastolic dysfunction...
April 2017: Hypertension
https://www.readbyqxmd.com/read/28218795/defensive-coping-and-essential-amino-acid-markers-as-possible-predictors-for-structural-vascular-disease-in-an-african-and-caucasian-male-cohort-the-sabpa-study
#3
Marisa Möller, Leoné Malan, Martin Magnusson, Carina M C Mels, Nico T Malan
Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. The Coping Strategy Indicator questionnaire identified DefS participants...
February 20, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28209576/differences-in-hemodynamics-and-rupture-rate-of-aneurysms-at-the-bifurcation-of-the-basilar-and-internal-carotid-arteries
#4
R Doddasomayajula, B Chung, F Hamzei-Sichani, C M Putman, J R Cebral
BACKGROUND AND PURPOSE: Cerebral aneurysms in the posterior circulation are known to have a higher rupture risk than those in the anterior circulation. We sought to test the hypothesis that differences in hemodynamics can explain the difference in rupture rates. MATERIALS AND METHODS: A total of 117 aneurysms, 63 at the tip of the basilar artery (27 ruptured, 36 unruptured, rupture rate = 43%) and 54 at the bifurcation of the internal carotid artery (11 ruptured, 43 unruptured, rupture rate = 20%) were analyzed with image-based computational fluid dynamics...
February 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28191460/assessment-of-influences-of-stenoses-in-right-carotid-artery-on-left-carotid-artery-using-wall-stress-marker
#5
Arindam Bit, Dushali Ghagare, Albert A Rizvanov, Himadri Chattopadhyay
Purpose. Atherosclerosis is a diseased condition of blood vessel. It causes partial blockage in lumen of vessel and affects hemodynamic of localized flowing blood. Complex geometries like region of bifurcation also affects hemodynamic to a larger extent. Complexity further increases in presence of stenoses at region of bifurcation. Such morphological change in vessel largely affects parent as well as corresponding sister and daughter vessels. In this paper, complexity in hemodynamic of blood in pair of carotid arteries (left and right carotid arteries) is evaluated in presence of stenoses at basilar segment of right artery in three-dimensional domain using reconstructed tomographic images of patient...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28155720/effects-of-8-week-swimming-training-on-carotid-arterial-stiffness-and-hemodynamics-in-young-overweight-adults
#6
Wen-Xue Yuan, Hai-Bin Liu, Feng-Shan Gao, Yan-Xia Wang, Kai-Rong Qin
BACKGROUND: Exercise has been found to either reduce or increase arterial stiffness. Land-based exercise modalities have been documented as effective physical therapies to decrease arterial stiffness. However, these land-based exercise modalities may not be suitable for overweight individuals, in terms of risks of joint injury. The purpose of this study was to determine the effects of 8-week swimming training and 4-week detraining on carotid arterial stiffness and hemodynamics in young overweight adults...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28155716/a-multi-component-parallel-plate-flow-chamber-system-for-studying-the-effect-of-exercise-induced-wall-shear-stress-on-endothelial-cells
#7
Yan-Xia Wang, Cheng Xiang, Bo Liu, Yong Zhu, Yong Luan, Shu-Tian Liu, Kai-Rong Qin
BACKGROUND: In vivo studies have demonstrated that reasonable exercise training can improve endothelial function. To confirm the key role of wall shear stress induced by exercise on endothelial cells, and to understand how wall shear stress affects the structure and the function of endothelial cells, it is crucial to design and fabricate an in vitro multi-component parallel-plate flow chamber system which can closely replicate exercise-induced wall shear stress waveforms in artery. METHODS: The in vivo wall shear stress waveforms from the common carotid artery of a healthy volunteer in resting and immediately after 30 min acute aerobic cycling exercise were first calculated by measuring the inner diameter and the center-line blood flow velocity with a color Doppler ultrasound...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28155699/contrast-enhanced-micro-ct-imaging-in-murine-carotid-arteries-a-new-protocol-for-computing-wall-shear-stress
#8
Ruoyu Xing, David De Wilde, Gayle McCann, Yanto Ridwan, Jelle T C Schrauwen, Anton F W van der Steen, Frank J H Gijsen, Kim Van der Heiden
BACKGROUND: Wall shear stress (WSS) is involved in the pathophysiology of atherosclerosis. The correlation between WSS and atherosclerosis can be investigated over time using a WSS-manipulated atherosclerotic mouse model. To determine WSS in vivo, detailed 3D geometry of the vessel network is required. However, a protocol to reconstruct 3D murine vasculature using this animal model is lacking. In this project, we evaluated the adequacy of eXIA 160, a small animal contrast agent, for assessing murine vascular network on micro-CT...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28126983/combination-of-magnetic-resonance-angiography-and-computational-fluid-dynamics-may-predict-the-risk-of-stroke-in-patients-with-asymptomatic-carotid-plaques
#9
Qian Jia, Hongbin Liu, Yanping Li, Xiaoxi Wang, Jinju Jia, Yuying Li
BACKGROUND Atherosclerosis plaques in the carotid arteries frequently have been found in patients with stroke. However, the pathogenesis of carotid plaque from asymptomatic to cerebrovascular events is a complex process which is still not completely understood. We aimed to investigate the prognosis of asymptomatic carotid atherosclerotic plaques by use of magnetic resonance angiography (MRA) combined with computational fluid dynamics (CFD). MATERIAL AND METHODS We prospectively studied a cohort of 228 participants (mean age 59...
January 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28113659/wall-shear-rate-measurement-validation-of-a-new-method-through-multi-physics-simulations
#10
Stefano Ricci, Abigail Swillens, Alessandro Ramalli, Patrick Segers, Piero Tortoli
Wall shear stress is known to affect the vessel endothelial function and to be related to important pathologies like the development of atherosclerosis. It is defined as the product of the blood viscosity by the blood velocity gradient at the wall position, i.e. the Wall Shear Rate (WSR). The WSR measurement is particularly challenging in important cardiovascular sites like the carotid bifurcation, because of the related complex flow configurations characterized by high spatial and temporal gradients, wall movement and clutter noise...
September 12, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28113333/machine-learning-approach-for-predicting-wall-shear-distribution-for-abdominal-aortic-aneurysm-and-carotid-bifurcation-models
#11
Milos Jordanski, Milos Radovic, Zarko Milosevic, Nenad Filipovic, Zoran Obradovic
Computer simulations based on the finite element method (FEM) represent powerful tools for modeling blood flow through arteries. However, due to its computational complexity, this approach may be inappropriate when results are needed quickly. In order to reduce computational time, in this paper we proposed an alternative machine learning based approach for calculation of wall shear stress (WSS) distribution, which may play an important role in mechanisms related to initiation and development of atherosclerosis...
December 14, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28092504/wall-shear-rate-measurement-validation-of-a-new-method-through-multiphysics-simulations
#12
Stefano Ricci, Abigail Swillens, Alessandro Ramalli, Patrick Segers, Piero Tortoli
Wall shear stress is known to affect the vessel endothelial function and to be related to important pathologies like the development of atherosclerosis. It is defined as the product of the blood viscosity by the blood velocity gradient at the wall position, i.e., the wall shear rate (WSR). The WSR measurement is particularly challenging in important cardiovascular sites, like the carotid bifurcation, because of the related complex flow configurations characterized by high spatial and temporal gradients, wall movement, and clutter noise...
January 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28039898/response-of-arterial-stiffness-four-weeks-after-terminating-short-term-aerobic-exercise-training-in-a-sedentary-lifestyle
#13
Murat Baykara, Adnan Demirel, İhsan Yavuzatmaca, Mehmet Bilgen
OBJECTIVES: The purpose of this study was to investigate the response of arterial stiffness in individuals with a sedentary lifestyle at 4 weeks after terminating a 2-week aerobic exercise session. METHODS: Arterial stiffness was evaluated in 38 participants before starting and after completing a prescribed aerobic exercise program and also at 4 weeks after returning back to their sedentary lifestyle. Parameters regarding arterial compliance, distensibility, wall stress, and the elastic modulus were estimated from the information gained from sonography on the dimensions of carotid and femoral arteries and a sphygmomanometer on the pulse pressure...
February 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27992352/machine-learning-approach-for-predicting-wall-shear-distribution-for-abdominal-aortic-aneurysm-and-carotid-bifurcation-models
#14
Milos Jordanski, Milos Radovic, Zarko Milosevic, Nenad Filipovic, Zoran Obradovic
Computer simulations based on the finite element method (FEM) represent powerful tools for modeling blood flow through arteries. However, due to its computational complexity, this approach may be inappropriate when results are needed quickly. In order to reduce computational time, in this paper we proposed an alternative machine learning based approach for calculation of wall shear stress (WSS) distribution, which may play an important role in mechanisms related to initiation and development of atherosclerosis...
December 14, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27925647/left-ventricular-function-assessed-by-one-point-carotid-wave-intensity-in-newly-diagnosed-untreated-hypertensive-patients
#15
Olga Vriz, Serena Favretto, Joanna Jaroch, Rychard Wojciech, Eduardo Bossone, Caterina Driussi, Francesco Antonini-Canterin, Paolo Palatini, Krystyna Loboz-Grudzien
OBJECTIVES: To investigate whether newly diagnosed untreated hypertensive patients show higher left ventricular (LV) contractility, as assessed by traditional echocardiographic indices and carotid wave intensity (WI) parameters, including amplitude of the peak during early (W1 ) and late systole (W2 ). METHODS: A total of 145 untreated hypertensive patients were compared with 145 age- and sex-matched normotensive subjects. They underwent comprehensive echocardiography and WI analysis...
January 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27898024/perinatal-arterial-ischemic-stroke-is-associated-to-materno-fetal-immune-activation-and-intracranial-arteritis
#16
Clémence Guiraut, Nicole Cauchon, Martin Lepage, Guillaume Sébire
The medium-size intra-cranial arteries arising from the carotid bifurcation are prone to perinatal arterial ischemic strokes (PAIS). PAIS' physiopathology needs to be better understood to develop preventive and therapeutic interventions that are currently missing. We hypothesized that materno-fetal inflammation leads to a vasculitis affecting selectively the carotidian tree and promoting a focal thrombosis and subsequent stroke. Dams were injected with saline or lipopolysaccharide (LPS) from Escherichia coli...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27865168/peristrut-microhemorrhages-a-possible-cause-of-in-stent-neoatherosclerosis
#17
Zaven Terzian, T Christian Gasser, Francis Blackwell, Fabien Hyafil, Liliane Louedec, Catherine Deschildre, Walid Ghodbane, Richard Dorent, Antonino Nicoletti, Marion Morvan, Mohammed Nejjari, Laurent Feldman, Graciela Pavon-Djavid, Jean-Baptiste Michel
BACKGROUND: In-stent neoatherosclerosis is characterized by the delayed appearance of markers of atheroma in the subintima, but the pathophysiology underlying this new disease entity remains unclear. METHODS AND RESULTS: We collected 20 human coronary artery stents by removal from explanted hearts. The mean duration of stent implantation was 34 months. In all samples, neoatherosclerosis was detected, particularly in peristrut areas. It consisted of foam cells and cholesterol clefts, with or without calcification, associated with neovascularization...
January 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27853578/influence-of-shear-stress-magnitude-and-direction-on-atherosclerotic-plaque-composition
#18
Ryan M Pedrigi, Vikram V Mehta, Sandra M Bovens, Zahra Mohri, Christian Bo Poulsen, Willy Gsell, Jordi L Tremoleda, Leila Towhidi, Ranil de Silva, Enrico Petretto, Rob Krams
The precise flow characteristics that promote different atherosclerotic plaque types remain unclear. We previously developed a blood flow-modifying cuff for ApoE(-/-) mice that induces the development of advanced plaques with vulnerable and stable features upstream and downstream of the cuff, respectively. Herein, we sought to test the hypothesis that changes in flow magnitude promote formation of the upstream (vulnerable) plaque, whereas altered flow direction is important for development of the downstream (stable) plaque...
October 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27830569/a-review-on-atherosclerotic-biology-wall-stiffness-physics-of-elasticity-and-its-ultrasound-based-measurement
#19
REVIEW
Anoop K Patel, Harman S Suri, Jaskaran Singh, Dinesh Kumar, Shoaib Shafique, Andrew Nicolaides, Sanjay K Jain, Luca Saba, Ajay Gupta, John R Laird, Argiris Giannopoulos, Jasjit S Suri
Functional and structural changes in the common carotid artery are biomarkers for cardiovascular risk. Current methods for measuring functional changes include pulse wave velocity, compliance, distensibility, strain, stress, stiffness, and elasticity derived from arterial waveforms. The review is focused on the ultrasound-based carotid artery elasticity and stiffness measurements covering the physics of elasticity and linking it to biological evolution of arterial stiffness. The paper also presents evolution of plaque with a focus on the pathophysiologic cascade leading to arterial hardening...
December 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27814428/modeling-the-effect-of-red-blood-cells-deformability-on-blood-flow-conditions-in-human-carotid-artery-bifurcation
#20
Janez Urevc, Iztok Žun, Milan Brumen, Boris Štok
The purpose of this work is to predict the effect of impaired red blood cells (RBCs) deformability on blood flow conditions in human carotid artery bifurcation. First, a blood viscosity model is developed that predicts the steady-state blood viscosity as a function of shear rate, plasma viscosity, and mechanical (and geometrical) properties of RBC's. Viscosity model is developed by modifying the well-known Krieger and Dougherty equation for monodisperse suspensions by using the dimensional analysis approach...
January 1, 2017: Journal of Biomechanical Engineering
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