keyword
MENU ▼
Read by QxMD icon Read
search

carotid wall stress

keyword
https://www.readbyqxmd.com/read/28611395/shear-stress-induces-endothelial-to-mesenchymal-transition-via-the-transcription-factor-snail
#1
Marwa M Mahmoud, Jovana Serbanovic-Canic, Shuang Feng, Celine Souilhol, Rouyu Xing, Sarah Hsiao, Akiko Mammoto, Jing Chen, Markus Ariaans, Sheila E Francis, Kim Van der Heiden, Victoria Ridger, Paul C Evans
Blood flow influences atherosclerosis by generating wall shear stress, which alters endothelial cell (EC) physiology. Low shear stress induces dedifferentiation of EC through a process termed endothelial-to-mesenchymal transition (EndMT). The mechanisms underlying shear stress-regulation of EndMT are uncertain. Here we investigated the role of the transcription factor Snail in low shear stress-induced EndMT. Studies of cultured EC exposed to flow revealed that low shear stress induced Snail expression. Using gene silencing it was demonstrated that Snail positively regulated the expression of EndMT markers (Slug, N-cadherin, α-SMA) in EC exposed to low shear stress...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28592592/late-systolic-myocardial-loading-is-associated-with-left-atrial-dysfunction-in-hypertension
#2
Julio A Chirinos, Timothy S Phan, Amer A Syed, Zeba Hashmath, Harry G Oldland, Maheswara R Koppula, Ali Tariq, Khuzaima Javaid, Rachana Miller, Swapna Varakantam, Anjaneyulu Dunde, Vadde Neetha, Scott R Akers
BACKGROUND: Late systolic load has been shown to cause diastolic dysfunction in animal models. Although the systolic loading sequence of the ventricular myocardium likely affects its coupling with the left atrium (LA), this issue has not been investigated in humans. We aimed to assess the relationship between the myocardial loading sequence and LA function in human hypertension. METHODS AND RESULTS: We studied 260 subjects with hypertension and 19 normotensive age- and sex-matched controls...
June 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28573970/uncertainty-quantification-of-wall-shear-stress-in-intracranial-aneurysms-using-a-data-driven-statistical-model-of-systemic-blood-flow-variability
#3
Ali Sarrami-Foroushani, Toni Lassila, Ali Gooya, Arjan J Geers, Alejandro F Frangi
Adverse wall shear stress (WSS) patterns are known to play a key role in the localisation, formation, and progression of intracranial aneurysms (IAs). Complex region-specific and time-varying aneurysmal WSS patterns depend both on vascular morphology as well as on variable systemic flow conditions. Computational fluid dynamics (CFD) has been proposed for characterising WSS patterns in IAs; however, CFD simulations often rely on deterministic boundary conditions that are not representative of the actual variations in blood flow...
December 8, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28506222/computational-fluid-dynamics-study-of-intra-arterial-chemotherapy-for-oral-cancer
#4
Hiroaki Kitajima, Marie Oshima, Toshinori Iwai, Yoshihito Ohhara, Yasuharu Yajima, Kenji Mitsudo, Iwai Tohnai
BACKGROUND: Intra-arterial chemotherapy (IAC) for oral cancer can deliver a higher concentration of anticancer agent into a tumor-feeding artery than intravenous systemic chemotherapy. However, distribution of anticancer agent into several branches of the external carotid artery (ECA) in IAC has not demonstrated sufficient treatment efficacy. To improve the effectiveness of IAC, the flow distribution of anticancer agent into the branches of the ECA in several IAC methods was investigated using computational fluid dynamics (CFD)...
May 15, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28501327/echo-particle-image-velocimetry-for-estimation-of-carotid-artery-wall-shear-stress-repeatability-reproducibility-and-comparison-with-phase-contrast-magnetic-resonance-imaging
#5
Arati Gurung, Phillip E Gates, Luciano Mazzaro, Jonathan Fulford, Fuxing Zhang, Alex J Barker, Jean Hertzberg, Kunihiko Aizawa, William D Strain, Salim Elyas, Angela C Shore, Robin Shandas
Measurement of hemodynamic wall shear stress (WSS) is important in investigating the role of WSS in the initiation and progression of atherosclerosis. Echo particle image velocimetry (echo PIV) is a novel ultrasound-based technique for measuring WSS in vivo that has previously been validated in vitro using the standard optical PIV technique. We evaluated the repeatability and reproducibility of echo PIV for measuring WSS in the human common carotid artery. We measured WSS in 28 healthy participants (18 males and 10 females, mean age: 56 ± 12 y)...
May 10, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28409823/a-sphingosine-1-phosphate-receptor-type-1-agonist-asp4058-suppresses-intracranial-aneurysm-through-promoting-endothelial-integrity-and-blocking-macrophage-transmigration
#6
Rie Yamamoto, Tomohiro Aoki, Hirokazu Koseki, Miyuki Fukuda, Jun Hirose, Keiichi Tsuji, Katsumi Takizawa, Shinichiro Nakamura, Haruka Miyata, Nozomu Hamakawa, Hidetoshi Kasuya, Kazuhiko Nozaki, Yoshitaka Hirayama, Ichiro Aramori, Shuh Narumiya
BACKGROUND AND PURPOSE: Intracranial aneurysm (IA), common in the general public, causes lethal subarachnoid haemorrhage on rupture. It is, therefore, of utmost importance to prevent the IA from rupturing. However, there is currently no medical treatment. Recent studies suggest that IA is the result of chronic inflammation in the arterial wall caused by endothelial dysfunction and infiltrating macrophages. The sphingosine-1-phosphate receptor type 1 (S1P1 receptor) is present on the endothelium and promotes its barrier function...
July 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28382440/tetralogy-of-fallot-surgical-repair-shunt-configurations-ductus-arteriosus-and-the-circle-of-willis
#7
Senol Piskin, Gozde Unal, Ahmet Arnaz, Tayyar Sarioglu, Kerem Pekkan
In this study, hemodynamic performance of three novel shunt configurations that are considered for the surgical repair of tetralogy of Fallot (TOF) disease are investigated in detail. Clinical experience suggests that the shunt location, connecting angle, and its diameter can influence the post-operative physiology and the neurodevelopment of the neonatal patient. An experimentally validated second order computational fluid dynamics (CFD) solver and a parametric neonatal diseased great artery model that incorporates the ductus arteriosus (DA) and the full patient-specific circle of Willis (CoW) are employed...
June 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28372866/increased-interarm-blood-pressure-difference-is-associated-with-autonomic-dysfunction-and-atherosclerosis-in-patients-with-chest-pain-and-no-history-of-coronary-artery-disease
#8
Hui-Jeong Hwang, Il Suk Sohn, Dong-Hee Kim, Chang-Bum Park, Jin-Man Cho, Chong-Jin Kim
OBJECTIVES: Interarm blood pressure (BP) difference has been reported to be associated with atherosclerosis and increased cardiovascular death. We were to investigate associations of interarm systolic blood pressure (SBP) difference with heart rate recovery (HRR) after exercise, an index of autonomic function, and carotid atherosclerotic markers, and to evaluate the association of interarm SBP difference with concurrent coronary artery disease (CAD). METHODS: A total of 995 consecutive patients who underwent treadmill stress echocardiography with chest pain but no history of CAD were enrolled...
August 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28344561/fetal-growth-restriction-induces-heterogeneous-effects-on-vascular-biomechanical-and-functional-properties-in-guinea-pigs-cavia-porcellus
#9
Daniel Cañas, Emilio A Herrera, Claudio García-Herrera, Diego Celentano, Bernardo J Krause
Aim: Fetal growth restriction (FGR) is associated with a variety of cardiometabolic diseases in adulthood which could involve remodeling processes of the vascular walls that could start in the fetal period. However, there is no consensus whether this remodeling affects in a similar way the whole vascular system. We aimed to determine the effects of FGR on the vasoactive and biomechanical properties of umbilical and systemic vessels in fetal guinea pigs. Methods: FGR was induced by implanting ameroid occluders at mid-gestation in uterine arteries of pregnant guinea pigs, whilst the control group was exposed to simulated surgery...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28339485/chronic-parp-1-inhibition-reduces-carotid-vessel-remodeling-and-oxidative-damage-of-the-dorsal-hippocampus-in-spontaneously-hypertensive-rats
#10
Krisztian Eros, Klara Magyar, Laszlo Deres, Arpad Skazel, Adam Riba, Zoltan Vamos, Tamas Kalai, Ferenc Gallyas, Balazs Sumegi, Kalman Toth, Robert Halmosi
Vascular remodeling during chronic hypertension may impair the supply of tissues with oxygen, glucose and other compounds, potentially unleashing deleterious effects. In this study, we used Spontaneously Hypertensive Rats and normotensive Wistar-Kyoto rats with or without pharmacological inhibition of poly(ADP-ribose)polymerase-1 by an experimental compound L-2286, to evaluate carotid artery remodeling and consequent damage of neuronal tissue during hypertension. We observed elevated oxidative stress and profound thickening of the vascular wall with fibrotic tissue accumulation induced by elevated blood pressure...
2017: PloS One
https://www.readbyqxmd.com/read/28273662/dedifferentiated-fat-cells-as-a-novel-source-for-cell-therapy-to-target-neonatal-hypoxic-ischemic-encephalopathy
#11
Alkisti Mikrogeorgiou, Yoshiaki Sato, Taiki Kondo, Tetsuo Hattori, Yuichiro Sugiyama, Miharu Ito, Akiko Saito, Keiko Nakanishi, Masahiro Tsuji, Tomohiko Kazama, Koichiro Kano, Taro Matsumoto, Masahiro Hayakawa
Neonatal hypoxic-ischemic (HI) encephalopathy (HIE) remains a major cause of mortality and persistent neurological disabilities in affected individuals. At present, hypothermia is considered to be the only applicable treatment option, although growing evidence suggests that cell-based therapy might achieve better outcomes. Dedifferentiated fat (DFAT) cells are derived from mature adipocytes via a dedifferentiation strategy called ceiling culture. Their abundance and ready availability might make them an ideal therapeutic tool for the treatment of HIE...
March 9, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28223475/reduced-first-phase-ejection-fraction-and-sustained-myocardial-wall-stress-in-hypertensive-patients-with-diastolic-dysfunction-a-manifestation-of-impaired-shortening-deactivation-that-links-systolic-to-diastolic-dysfunction-and-preserves-systolic-ejection-fraction
#12
Haotian Gu, Ye Li, Henry Fok, John Simpson, Jonathan C Kentish, Ajay M Shah, Philip J Chowienczyk
Impaired shortening deactivation of cardiac myocytes could sustain myocardial contraction, preserving ejection fraction at the expense of diastolic dysfunction. We examined the relationship between first-phase ejection fraction (EF1), the fraction of left ventricular volume ejected from the start of systole to the time of the first peak in left ventricular pressure (corresponding to the time of maximal ventricular shortening) to the duration of myocardial contraction and diastolic function in patients with hypertension (n=163), and varying degrees of diastolic dysfunction...
April 2017: Hypertension
https://www.readbyqxmd.com/read/28218795/defensive-coping-and-essential-amino-acid-markers-as-possible-predictors-for-structural-vascular-disease-in-an-african-and-caucasian-male-cohort-the-sabpa-study
#13
Marisa Möller, Leoné Malan, Martin Magnusson, Carina M C Mels, Nico T Malan
Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. The Coping Strategy Indicator questionnaire identified DefS participants...
May 2017: Psychophysiology
https://www.readbyqxmd.com/read/28209576/differences-in-hemodynamics-and-rupture-rate-of-aneurysms-at-the-bifurcation-of-the-basilar-and-internal-carotid-arteries
#14
R Doddasomayajula, B Chung, F Hamzei-Sichani, C M Putman, J R Cebral
BACKGROUND AND PURPOSE: Cerebral aneurysms in the posterior circulation are known to have a higher rupture risk than those in the anterior circulation. We sought to test the hypothesis that differences in hemodynamics can explain the difference in rupture rates. MATERIALS AND METHODS: A total of 117 aneurysms, 63 at the tip of the basilar artery (27 ruptured, 36 unruptured, rupture rate = 43%) and 54 at the bifurcation of the internal carotid artery (11 ruptured, 43 unruptured, rupture rate = 20%) were analyzed with image-based computational fluid dynamics...
February 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28191460/assessment-of-influences-of-stenoses-in-right-carotid-artery-on-left-carotid-artery-using-wall-stress-marker
#15
Arindam Bit, Dushali Ghagare, Albert A Rizvanov, Himadri Chattopadhyay
Purpose. Atherosclerosis is a diseased condition of blood vessel. It causes partial blockage in lumen of vessel and affects hemodynamic of localized flowing blood. Complex geometries like region of bifurcation also affects hemodynamic to a larger extent. Complexity further increases in presence of stenoses at region of bifurcation. Such morphological change in vessel largely affects parent as well as corresponding sister and daughter vessels. In this paper, complexity in hemodynamic of blood in pair of carotid arteries (left and right carotid arteries) is evaluated in presence of stenoses at basilar segment of right artery in three-dimensional domain using reconstructed tomographic images of patient...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28155720/effects-of-8-week-swimming-training-on-carotid-arterial-stiffness-and-hemodynamics-in-young-overweight-adults
#16
Wen-Xue Yuan, Hai-Bin Liu, Feng-Shan Gao, Yan-Xia Wang, Kai-Rong Qin
BACKGROUND: Exercise has been found to either reduce or increase arterial stiffness. Land-based exercise modalities have been documented as effective physical therapies to decrease arterial stiffness. However, these land-based exercise modalities may not be suitable for overweight individuals, in terms of risks of joint injury. The purpose of this study was to determine the effects of 8-week swimming training and 4-week detraining on carotid arterial stiffness and hemodynamics in young overweight adults...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28155716/a-multi-component-parallel-plate-flow-chamber-system-for-studying-the-effect-of-exercise-induced-wall-shear-stress-on-endothelial-cells
#17
Yan-Xia Wang, Cheng Xiang, Bo Liu, Yong Zhu, Yong Luan, Shu-Tian Liu, Kai-Rong Qin
BACKGROUND: In vivo studies have demonstrated that reasonable exercise training can improve endothelial function. To confirm the key role of wall shear stress induced by exercise on endothelial cells, and to understand how wall shear stress affects the structure and the function of endothelial cells, it is crucial to design and fabricate an in vitro multi-component parallel-plate flow chamber system which can closely replicate exercise-induced wall shear stress waveforms in artery. METHODS: The in vivo wall shear stress waveforms from the common carotid artery of a healthy volunteer in resting and immediately after 30 min acute aerobic cycling exercise were first calculated by measuring the inner diameter and the center-line blood flow velocity with a color Doppler ultrasound...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28155699/contrast-enhanced-micro-ct-imaging-in-murine-carotid-arteries-a-new-protocol-for-computing-wall-shear-stress
#18
Ruoyu Xing, David De Wilde, Gayle McCann, Yanto Ridwan, Jelle T C Schrauwen, Anton F W van der Steen, Frank J H Gijsen, Kim Van der Heiden
BACKGROUND: Wall shear stress (WSS) is involved in the pathophysiology of atherosclerosis. The correlation between WSS and atherosclerosis can be investigated over time using a WSS-manipulated atherosclerotic mouse model. To determine WSS in vivo, detailed 3D geometry of the vessel network is required. However, a protocol to reconstruct 3D murine vasculature using this animal model is lacking. In this project, we evaluated the adequacy of eXIA 160, a small animal contrast agent, for assessing murine vascular network on micro-CT...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28126983/combination-of-magnetic-resonance-angiography-and-computational-fluid-dynamics-may-predict-the-risk-of-stroke-in-patients-with-asymptomatic-carotid-plaques
#19
Qian Jia, Hongbin Liu, Yanping Li, Xiaoxi Wang, Jinju Jia, Yuying Li
BACKGROUND Atherosclerosis plaques in the carotid arteries frequently have been found in patients with stroke. However, the pathogenesis of carotid plaque from asymptomatic to cerebrovascular events is a complex process which is still not completely understood. We aimed to investigate the prognosis of asymptomatic carotid atherosclerotic plaques by use of magnetic resonance angiography (MRA) combined with computational fluid dynamics (CFD). MATERIAL AND METHODS We prospectively studied a cohort of 228 participants (mean age 59...
January 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28113659/wall-shear-rate-measurement-validation-of-a-new-method-through-multi-physics-simulations
#20
Stefano Ricci, Abigail Swillens, Alessandro Ramalli, Patrick Segers, Piero Tortoli
Wall shear stress is known to affect the vessel endothelial function and to be related to important pathologies like the development of atherosclerosis. It is defined as the product of the blood viscosity by the blood velocity gradient at the wall position, i.e. the Wall Shear Rate (WSR). The WSR measurement is particularly challenging in important cardiovascular sites like the carotid bifurcation, because of the related complex flow configurations characterized by high spatial and temporal gradients, wall movement and clutter noise...
September 12, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
keyword
keyword
81180
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"