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diabetic neuropathy and ncv

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https://www.readbyqxmd.com/read/29791761/nerve-action-potential-amplitudes-a-robust-marker-of-diabetic-peripheral-neuropathy
#1
Marie Monlun, Marie Hugo, Laurence Blanco, Kamel Mohammedi, Ahdab Rechdi, Laure Alexandre, Stéphane Poirot-Mazeres, Kalina Rajaobelina, Vincent Rigalleau
We were interested in the recent publication of Peterson et al. (1) who reported a progressive reduction of sural nerve amplitudes from 10.9μV to 7.0μV, during a ten year follow-up of 87 people with varying degrees of glucose intolerance. This reduction was more pronounced for people whose glucose tolerance deteriorated during the follow-up period, and paralleled their increasing HbA1c. In contrast, nerve conduction velocities only decreased from 47.6 to 45.8 m/s, without any significant relation to HbA1c This article is protected by copyright...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29750001/effect-of-combined-dyslipidemia-and-hyperglycemia-on-diabetic-peripheral-neuropathy-in-alloxan-induced-diabetic-wbn-kob-rats
#2
Kiyokazu Ozaki, Yui Terayama, Tetsuro Matsuura, Isao Narama
Clinical and experimental research have suggested that dyslipidemia aggravates diabetic peripheral neuropathy (DPN). However, whether dyslipidemia is a risk factor for DPN remains unclear. To investigate the effect of dyslipidemia on DPN, morphological features of peripheral nerves were analyzed in diabetic rats treated with a high-fat diet (HFD). Male rats were divided into four groups: nondiabetic rats (N), alloxan-induced diabetic rats (AL), diabetic rats treated with an HFD (AH), and nondiabetic rats treated with an HFD (HF)...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29719281/expression-of-nrf2-promotes-schwann-cell-mediated-sciatic-nerve-recovery-in-diabetic-peripheral-neuropathy
#3
Wei Tang, Xiangfang Chen, Haoqi Liu, Qian Lv, Junjie Zou, Yongquan Shi, Zhimin Liu
BACKGROUND/AIMS: High glucose-induced oxidative stress and inflammatory responses play an important role in painful diabetic neuropathy by activating the TLR4/NFκB signal pathway. Schwann cells (SCs) are integral to peripheral nerve biology, contributing to saltatory conduction along axons, nerve and axon development, and axonal regeneration. SCs provide a microenvironment favoring vascular regeneration but their low survival ratio in hyperglycemic conditions suppress the function to promote nerve growth...
April 26, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29701037/-warming-acupuncture-combined-with-conventional-acupuncture-for-diabetic-peripheral-neuropathy-with-syndrome-of-yang-deficiency-and-cold-coagulation-obstruction-of-collaterals-and-blood-stasis
#4
Guoqing Ma, Ting Ye, Zhongren Sun
OBJECTIVE: To compare the clinical efficacy differences between warming acupuncture and conventional acupuncture for diabetic peripheral neuropathy (DPN) with syndrome of yang deficiency and cold coagulation, obstruction of collaterals and blood stasis. METHODS: A total of 64 patients were randomly divided into a warming acupuncture group and a conventional acupuncture group, 32 cases in each one. Based on basic treatment of blood glucose regulation, warming acupuncture was applied at Pishu (BL 20), Shenshu (BL 23), Guanyuanshu (BL 26), Zusanli (ST 36), Chongyang (ST 42), Quchi (LI 11) and Hegu (LI 4) in the warming acupuncture group, while acupuncture was applied at the identical acupoints in the conventional acupuncture group...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29696049/peripheral-neuropathy-in-children-and-adolescents-with-insulin-dependent-diabetes-mellitus
#5
Nosrat Ghaemi, Hossein Hasanabadi, Farah Ashrafzadeh, Somaye Sarvari, Hamidreza Rahimi, Somayyeh Hashemian
Objective: Type 1 diabetes mellitus (T1DM) is a chronic immune-mediated disease. Diabetic peripheral neuropathy (DPN) is an important microvascular complication of T1DM. One of the most important risk factors for the development of DPN is poor glycemic control. We evaluated the prevalence of DPN among T1DM patients and determined the association between DPN and glycated hemoglobin (HbA1c) level. Materials & Methods: The subjects were recruited prospectively upon initial evaluation at Imam Reza Hospital, Mashhad, Iran from Jan 2013 to Jan 2015...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29695014/chronic-nerve-compression-accelerates-the-progression-of-diabetic-peripheral-neuropathy-in-a-rat-model-a-study-of-gene-expression-profiling
#6
Yiji Tu, Zenggan Chen, Junda Hu, Zuoyou Ding, William C Lineaweaver, A Lee Dellon, Feng Zhang
OBJECTIVE:  This article investigates the role of chronic nerve compression in the progression of diabetic peripheral neuropathy (DPN) by gene expression profiling. METHODS:  Chronic nerve compression was created in streptozotocin (STZ)-induced diabetic rats by wrapping a silicone tube around the sciatic nerve (SCN). Neurological deficits were evaluated using pain threshold test, motor nerve conduction velocity (MNCV), and histopathologic examination. Differentially expressed genes (DGEs) and metabolic processes associated with chronic nerve compression were analyzed...
April 25, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29676840/behavioral-morphological-and-electrophysiological-assessment-of-the-effects-of-type-2-diabetes-mellitus-on-large-and-small-nerve-fibers-in-zucker-diabetic-fatty-rat-zucker-lean-and-wistar-rats
#7
E Garcia-Perez, T Schönberger, M Sumalla, B Stierstorfer, R Solà, H Doods, J Serra, N Gorodetskaya
BACKGROUND: Peripheral neuropathy is a common complication in type 2 diabetes mellitus (T2DM). The most common presentation is in the form of a distal axonal sensory-motor polyneuropathy that involves large and small nerve fibers in variable proportion. METHODS: Zucker Diabetic Fatty rats (ZDF), Zucker Lean (ZL) and Wistar Han (WH) rats were used to asses the behavioral, morphological and electrophysiological effects that T2DM have on peripheral large and small nerve fibers of 6-40 week-old rats...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29649429/deletion-of-the-insulin-receptor-in-sensory-neurons-increases-pancreatic-insulin-levels
#8
Caleb W Grote, Natalie M Wilson, Natalie K Katz, Brianne L Guilford, Janelle M Ryals, Lesya Novikova, Lisa Stehno-Bittel, Douglas E Wright
Insulin is known to have neurotrophic properties and loss of insulin support to sensory neurons may contribute to peripheral diabetic neuropathy (PDN). Here, genetically-modified mice were generated in which peripheral sensory neurons lacked the insulin receptor (SNIRKO mice) to determine whether disrupted sensory neuron insulin signaling plays a crucial role in the development of PDN and whether SNIRKO mice develop symptoms of PDN due to reduced insulin neurotrophic support. Our results revealed that SNIRKO mice were euglycemic and never displayed significant changes in a wide range of sensorimotor behaviors, nerve conduction velocity or intraepidermal nerve fiber density...
April 9, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29625948/comparing-the-diagnostic-accuracy-of-simple-tests-to-screen-for-diabetic-peripheral-neuropathy-protocol-for-a-cross-sectional-study
#9
Kate Goddard, Prashanth Vas, Alistair Purves, Viktoria McMillan, Thomas Langford, Fiona Reid, Michael Edmonds
BACKGROUND: Various tests are used to detect diabetic peripheral neuropathy by assessing sense perception in the feet. Tests vary in terms of time and resources required. Simple tests are those that can be conducted quickly and easily in primary care without laboratory equipment. There are some limitations to these simple tests, an example being the variable amplitude of the 128 Hz tuning fork. A new test, VibraTip (McCallan Medical, UK), might be a valuable alternative as it emits a consistent amplitude and may offer improved diagnostic accuracy...
April 6, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29619066/efficacy-and-safety-of-the-injection-of-the-traditional-chinese-medicine-puerarin-for-the-treatment-of-diabetic-peripheral-neuropathy-a-systematic-review-and-meta-analysis-of-53-randomized-controlled-trials
#10
REVIEW
Baocheng Xie, Qinghui Wang, Chenhui Zhou, Jiahuan Wu, Daohua Xu
Objective: The injection of the traditional Chinese patent medicine puerarin has been widely used in the treatment of various diseases such as angina pectoris or ischemic stroke. We aim to evaluate the efficacy and safety of puerarin injection for the treatment of diabetic peripheral neuropathy (DPN). Methods: A systematic literature search was performed in seven medical databases from their inception until June 2017. 53 studies with RCTs, totaling 3284 patients, were included in this meta-analysis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29608799/one-stop-microvascular-screening-service-an-effective-model-for-the-early-detection-of-diabetic-peripheral-neuropathy-and-the-high-risk-foot
#11
O Binns-Hall, D Selvarajah, D Sanger, J Walker, A Scott, S Tesfaye
AIMS: To evaluate the feasibility of a one-stop microvascular screening service for the early diagnosis of diabetic distal symmetrical polyneuropathy, painful distal symmetrical polyneuropathy and the at-risk diabetic foot. METHODS: People with diabetes attending retinal screening in hospital and community settings had their feet examined by a podiatrist. Assessment included: Toronto Clinical Neuropathy Score evaluation; a 10-g monofilament test; and two validated, objective and quick measures of neuropathy obtained using the point-of-care devices 'DPN-Check', a hand-held device that measures sural nerve conduction velocity and amplitude, and 'Sudoscan', a device that measures sudomotor function...
April 2, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29606547/effect-of-aerobic-training-on-nerve-conduction-in-men-with-type-2-diabetes-and-peripheral-neuropathy-a-randomized-controlled-trial
#12
Farhad Gholami, Saeed Nikookheslat, Yaghoub Salekzamani, Normand Boule, Afshar Jafari
OBJECTIVE: Peripheral neuropathy (PN) is one of the long-term complications of diabetes. Few studies have investigated the role of regular exercise on diabetic PN. We examined the effect of aerobic training on nerve conduction velocity and action potential amplitude in the lower limbs of men with type 2 diabetes and PN. METHODS: In a randomized controlled study, 24 volunteers diagnosed with diabetic PN were randomly assigned to exercise or control groups. Aerobic training consisted of 20-45min walking or running at 50-70% of heart rate reserve for three sessions per week over 12weeks...
March 29, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29599806/wentong-huoxue-cream-can-inhibit-the-reduction-of-the-pain-related-molecule-plc-%C3%AE-3-in-the-dorsal-root-ganglion-of-a-rat-model-of-diabetic-peripheral-neuropathy
#13
Chengcheng Feng, Lijuan Xu, Shiyun Guo, Qian Chen, Yuguo Shen, Deng Zang, Li Ma
WenTong HuoXue Cream (WTHX-Cream) has been shown to effectively alleviate clinical symptoms of diabetic peripheral neuropathy (DPN). This study investigated the gene and protein expression of the pain-related molecule PLC- β 3 in the dorsal root ganglion (DRG) of DPN rats. 88 specific pathogen-free male Wistar rats were randomly divided into placebo (10 rats) and DPN model (78 rats) groups, and the 78 model rats were used to establish the DPN model by intraperitoneal injection of streptozotocin and were then fed a high-fat diet for 8 weeks...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29568686/transthyretin-familial-amyloid-polyneuropathy-ttr-fap-parameters-for-early-diagnosis
#14
Fabiola Escolano-Lozano, Ana Paula Barreiros, Frank Birklein, Christian Geber
Background: Familial transthyretin amyloidosis is a life-threatening disease presenting with sensorimotor and autonomic polyneuropathy. Delayed diagnosis has a detrimental effect on treatment and prognosis. To facilitate diagnosis, we analyzed data patterns of patients with transthyretin familial amyloid polyneuropathy (TTR-FAP) and compared them to polyneuropathies of different etiology for clinical and electrophysiological discriminators. Methods: Twenty-four patients with TTR-FAP and 48 patients with diabetic polyneuropathy (dPNP) were investigated (neurological impairment score NIS; neurological disability score NDS) in a cross-sectional design...
January 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29566410/mechanical-allodynia-predicts-better-outcome-of-surgical-decompression-for-painful-diabetic-peripheral-neuropathy
#15
Chenlong Liao, D Scott Nickerson, Massimiliano Visocchi, Min Yang, Pengfei Liu, Wenxiang Zhong, Han Zhou, Wenchuan Zhang
BACKGROUND:  To determine the role of mechanical allodynia (MA) in predicting good surgical outcome for painful diabetic peripheral neuropathy (DPN). METHODS:  A series of 192 patients with painful DPN were collected in this study, with 148 surgical patients and 44 patients in the control group. Both groups were further divided into subgroups based on the presence of MA on admission. Clinical evaluations including the visual analog scale (VAS), the Hospital Anxiety and Depression Scale (HADS), nerve conduction velocity (NCV), and high-resolution ultrasonography (cross-sectional area, CSA) were performed preoperatively and postoperatively...
March 22, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29555465/low-serum-bilirubin-levels-contribute-to-the-presence-and-progression-of-distal-symmetrical-polyneuropathy-in-chinese-patients-with-type-2-diabetes
#16
J Jin, W Wang, T Gu, C Chen, J Sun, W Chen, Y Bi, D Zhu
AIM: To investigate the association between serum bilirubin and distal symmetrical polyneuropathy (DSPN) in Chinese patients with type 2 diabetes (T2D). METHODS: A total of 1800 inpatients with T2D (including 68 with 1-year follow-ups) were consecutively enrolled between June 2014 and March 2017. DSPN was diagnosed according to criteria recommended by the Toronto Diabetic Neuropathy Expert Group in 2010. Clinical data were retrospectively collected. RESULTS: Patients with vs...
February 22, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29484377/glp%C3%A2-1r-agonists-ameliorate-peripheral-nerve-dysfunction-and-inflammation-via-p38-mapk-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathways-in-streptozotocin%C3%A2-induced-diabetic-rats
#17
Jingjing Ma, Min Shi, Xiangcheng Zhang, Xiaoning Liu, Juan Chen, Ridong Zhang, Xingzhou Wang, Hong Zhang
The present study aimed to investigate the mechanism of glucagon‑like peptide‑1 receptor (GLP‑1R) agonists in the progression of diabetic peripheral neuropathy (DPN) in streptozotocin (STZ)‑induced diabetic rats, through inflammatory signaling pathways. The DPN rat model was generated by intraperitoneal injection of STZ and then treated with the GLP‑1R agonist liraglutide or saline for 8 weeks. These animals were randomly divided into 4 groups (10 rats in each): The normal control + saline group, the normal control + liraglutide group, the diabetic + saline (DM) group and the diabetic + liraglutide (DML) group...
May 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29436863/proinsulin-expressing-dendritic-cells-in-type-2-neuropathic-diabetic-patients-with-and-without-foot-lesions
#18
Maria Sambataro, Luisa Sambado, Enrica Trevisiol, Matilde Cacciatore, Anna Furlan, Piero Maria Stefani, Elena Seganfreddo, Elisabetta Durante, Stefania Conte, Silvia Della Bella, Agostino Paccagnella, Angelo Paolo Dei Tos
Diabetic neuropathy is the most common complication of diabetes and is frequently associated with foot ischemia and infection, but its pathogenesis is controversial. We hypothesized that proinsulin expression in peripheral blood mononuclear cells is a process relevant to this condition and could represent a link among hyperglycemia, nerve susceptibility, and diabetic foot lesions. We assessed proinsulin expression by using flow cytometry in dendritic cells from control participants and patients with type 2 diabetic with or without peripheral neuropathy or accompanied by diabetic foot...
February 12, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29429781/high-prevalence-and-incidence-of-diabetic-peripheral-neuropathy-in-children-and-adolescents-with-type-1-diabetes-mellitus-results-from-a-five-year-prospective-cohort-study
#19
Isabella Walter-Höliner, Daniela Seick Barbarini, Jürg Lütschg, Anya Blassnig-Ezeh, Ulrike Zanier, Christoph H Saely, Burkhard Simma
BACKGROUND: In this prospective cohort study, we investigated the prevalence of diabetic peripheral neuropathy at baseline and after five years of follow-up in children and adolescents with type 1 diabetes mellitus using both measurements of nerve conduction velocity and clinical neurological examination. METHODS: A total of 38 patients who underwent insulin pump or intensive insulin therapy were included. The subjects averaged 12.6 ± 2.4 years of age and their diabetes duration averaged 5...
March 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29419686/the-clinical-efficacy-of-epalrestat-combined-with-%C3%AE-lipoic-acid-in-diabetic-peripheral-neuropathy-protocol-for-a-systematic-review-and-meta-analysis
#20
Xiaotong Wang, Haixiong Lin, Shuai Xu, Yuanlin Jin, Ren Zhang
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common long-term complication of diabetes mellitus, affecting patients in the world. Epalrestat combined with α-lipoic acid (ALA) is the most frequent combine therapy used in the DPN researches. We aim to assess the effectiveness and safety of epalrestat combined with ALA in patients with DPN, compare with epalrestat alone. METHODS: We will search Cochrane Library, PubMed, Wanfang Data, China National Knowledge Infrastructure, VIP Chinese Science and Technology Journals Database, and Chinese Biomedical Database from inception until October 31th, 2017...
February 2018: Medicine (Baltimore)
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