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https://www.readbyqxmd.com/read/28899883/microrna-146a-mimics-reduce-the-peripheral-neuropathy-in-type-ii-diabetic-mice
#1
Xian Shuang Liu, Baoyan Fan, Alexandra Szalad, Longfei Jia, Lei Wang, Xinli Wang, Wanlong Pan, Li Zhang, Ruilan Zhang, Jiani Hu, Xiao Ming Zhang, Michael Chopp, Zheng Gang Zhang
MicroRNA-146a (miR-146a) regulates multiple immune diseases. However, the role of miR-146a in diabetic peripheral neuropathy (DPN) has not been investigated. We found that mice (db/db) with type II diabetes exhibited substantial down-regulation of miR-146a in sciatic nerve tissue. Systemic administration of miR-146a mimics to diabetic mice elevated miR-146a levels in plasma and sciatic nerve tissue and substantially increased motor and sensory nerve conduction velocities by 29% and 11%, respectively, and regional blood flow by 50% in sciatic nerve tissue...
September 12, 2017: Diabetes
https://www.readbyqxmd.com/read/28882470/an-observational-study-of-vitamin-b12-levels-and-peripheral-neuropathy-profile-in-patients-of-diabetes-mellitus-on-metformin-therapy
#2
Kamesh Gupta, Anand Jain, Anurag Rohatgi
METHODS: A descriptive, observational study was completed in a tertiary care hospital between November 2014 and March 2016. Fifty consecutive patients of Type 2-Diabetes Mellitus who had been on metformin therapy for at least three months were included in our study. Several Parameters were compared with vitamin B12 levels and severity of peripheral neuropathy (using Toronto Clinical Scoring System (TCSS) and Nerve Conduction Velocity). These included the duration of diabetes, duration of metformin usage, dietary history, and HbA1c levels...
August 25, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28864291/functional-recovery-upon-human-dental-pulp-stem-cell-transplantation-in-a-diabetic-neuropathy-rat-model
#3
Indrani Datta, Naini Bhadri, Pradnya Shahani, Debanjana Majumdar, Sowmithra Sowmithra, Rema Razdan, Ramesh Bhonde
Diabetic neuropathy (DN) is among the most debilitating complications of diabetes. Here, we investigated the effects of human dental pulp stem cell (DPSC) transplantation in Streptozotocin (STZ)-induced neuropathic rats. Six weeks after STZ injection, DPSCs were transplanted through two routes, intravenous (IV) or intramuscular (IM), in single or two repeat doses. Two weeks after transplantation, a significant improvement in hyperalgesia, grip-strength, motor coordination and nerve conduction velocity was observed in comparison with controls...
August 29, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28861044/diabetic-neuropathy-evaluated-by-a-novel-device-sural-nerve-conduction-is-associated-with-glycemic-control-and-ankle-brachial-pressure-index-in-japanese-patients-with-diabetes
#4
Hidetaka Hamasaki, Yasuteru Hamasaki
BACKGROUND: Currently, no international diagnostic criteria for diabetic neuropathy (DN) have been established. Recently, a novel point-of-care sural nerve conduction device has been developed. We aimed to investigate associations between DN and clinical parameters related to the development and progression of DN by using this novel device. METHODS: We conducted a retrospective observational study in patients with diabetes whose sural nerve functions were measured using DPN Check between January 2015 and October 2016...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28841867/yang-warming-method-in-the-treatment-of-diabetic-peripheral-neuropathy-an-updated-systematic-review-and-meta-analysis
#5
REVIEW
Sharad Panthi, Xirun Jing, Chenghan Gao, Tianshu Gao
BACKGROUND: Various studies have suggested the effectiveness of Chinese medicine in the treatment of diabetic peripheral neuropathy (DPN). There are several principles and methods in Chinese medicine for the treatment of DPN and yang-warming method is one of them. The purpose of this meta-analysis was to review the effectiveness and safety of yang-warming method using yang-warming Chinese medicine (YCM) in the treatment of DPN. METHODS: A computer-based search of the articles from January 2001 to April 2016 with Chinese and English databases such as CNKI, CBM, Wanfang, VIP, Medline, Embase and Cochrane central register of controlled trials as well as manual search of the related articles was conducted...
August 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28772216/minocycline-attenuates-the-development-of-diabetic-neuropathy-by-inhibiting-spinal-cord-notch-signaling-in-rat
#6
Cheng Yang, Jie Gao, Banglin Wu, Nuo Yan, Hui Li, Yiqing Ren, Yufei Kan, Jiamin Liang, Yang Jiao, Yonghao Yu
We studied the effects of minocycline (an inhibitor of microglial activation) on the expression and activity of Notch-1 receptor, and explored the therapeutic efficacy of minocycline combined with Notch inhibitor DAPT in the treatment of diabetic neuropathic pain (DNP). Diabetic rat model was established by intraperitoneal injection (ip) of Streptozotocin (STZ). Expression and activity of Notch-1 and expression of macrophage/microglia marker Iba-1 were detected by WB. Diabetes induction significantly attenuated sciatic nerve conduction velocity, and dramatically augmented the expression and the activity of Notch-1 in the lumbar enlargement of the spinal cord...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28730568/anemia-an-independent-risk-factor-of-diabetic-peripheral-neuropathy-in-type-2-diabetic-patients
#7
Fan Wu, Yuanyuan Jing, Xiaojun Tang, Dai Li, Lilin Gong, Hongyan Zhao, Li He, Qifu Li, Rong Li
AIMS: Recently, the association between anemia and diabetic microvascular complications has been studied. Diabetic peripheral neuropathy (DPN) is also a common complication of type 2 diabetes mellitus (T2DM), while the relationship between anemia and DPN is rarely investigated. The aim of this study is to evaluate the association between anemia and DPN in T2DM. METHODS: In this cross-sectional study, 1134 T2DM inpatients were enrolled. The diagnosis of DPN was based on neuropathy system score (NSS) and neuropathy disability score (NDS)...
July 21, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28719619/diagnostic-utility-of-corneal-confocal-microscopy-and-intra-epidermal-nerve-fibre-density-in-diabetic-neuropathy
#8
Uazman Alam, Maria Jeziorska, Ioannis N Petropoulos, Omar Asghar, Hassan Fadavi, Georgios Ponirakis, Andrew Marshall, Mitra Tavakoli, Andrew J M Boulton, Nathan Efron, Rayaz A Malik
OBJECTIVES: Corneal confocal microscopy (CCM) is a rapid, non-invasive, reproducible technique that quantifies small nerve fibres. We have compared the diagnostic capability of CCM against a range of established measures of nerve damage in patients with diabetic neuropathy. METHODS: In this cross sectional study, thirty subjects with Type 1 diabetes without neuropathy (T1DM), thirty one T1DM subjects with neuropathy (DSPN) and twenty seven non-diabetic healthy control subjects underwent detailed assessment of neuropathic symptoms and neurologic deficits, quantitative sensory testing (QST), electrophysiology, skin biopsy and corneal confocal microscopy (CCM)...
2017: PloS One
https://www.readbyqxmd.com/read/28682956/diphenyleneiodonium-mitigates-bupivacaine-induced-sciatic-nerve-damage-in-a-diabetic-neuropathy-rat-model-by-attenuating-oxidative-stress
#9
Zhong-Hua Ji, Zhong-Jie Liu, Zi-Ting Liu, Wei Zhao, Brian A Williams, Hong-Fei Zhang, Le Li, Shi-Yuan Xu
BACKGROUND: Increased oxidative stress has been linked to local anesthetic-induced nerve injury in a diabetic neuropathy (DN) rat model. The current study explores the effects of diphenyleneiodonium (DPI) chloride, an NADPH oxidase (NOX) inhibitor, on bupivacaine-induced sciatic nerve injury in DN rats. METHODS: A rat DN model was established through high-fat diet feeding and streptozotocin injection. The model was confirmed via testing (i) blood glucose, (ii) hindpaw allodynia responses to von Frey (VF) monofilaments, (iii) paw withdrawal thermal latency (PWTL), and (iv) nerve conduction velocity (NCV)...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28652546/clinical-application-of-ghrelin-for-diabetic-peripheral-neuropathy
#10
Hiroaki Ueno, Tomomi Shiiya, Kazuhiro Nagamine, Wakaba Tsuchimochi, Hideyuki Sakoda, Kazutaka Shiomi, Kenji Kangawa, Masamitsu Nakazato
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, and its progression significantly worsens the patient's quality of life. Although several drugs are available for DPN, all of these provide only symptomatic relief. We investigated the therapeutic effects of ghrelin for DPN, based on its various physiological functions. Seven patients with type 2 diabetes with typical clinical signs and symptoms of DPN were hospitalized. Synthetic human ghrelin (1.0 μg/kg) was administered intravenously for 14 days...
2017: Endocrine Journal
https://www.readbyqxmd.com/read/28595477/positive-effects-of-plantar-vibration-training-for-the-treatment-of-diabetic-peripheral-neuropathy-a-pilot-study
#11
Katerina Stambolieva, Dorina Petrova, Mariya Irikeva
PURPOSE: To evaluate the effectiveness of 8-week low-frequency plantar vibration training on patients with sensorimotor diabetic peripheral neuropathy (DPN). PARTICIPANTS: Twelve patients took part in the investigation. RESULTS: An increase of the nerve conductive velocity of soral and peroneal nerves of feet, increased postural stability, and disappearance of the pain and tingling were observed. CONCLUSION: The obtained results provide evidence for beneficial effects of 8-week plantar vibration training in patients with DPN...
June 9, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28582723/neutrophil-to-lymphocyte-ratio-is-associated-with-diabetic-peripheral-neuropathy-in-type-2-diabetes-patients
#12
Siying Liu, Hangping Zheng, Xiaoming Zhu, Fei Mao, Shuo Zhang, Hongli Shi, Yiming Li, Bin Lu
OBJECTIVE: Diabetic peripheral neuropathy (DPN) had been demonstrated as a chronic inflammation state and one of the most common complications of type 2 diabetes mellitus (T2DM). Neutrophil-to-lymphocyte ratio (NLR) is a novel marker to reflect many kinds of chronic inflammation disease including diabetes. We aim to evaluate the association between NLR and DPN and to determine whether NLR could be a new indicator of DPN in type 2 diabetes patients. METHODS: We retrospect the consecutive medical files of T2DM patients...
May 12, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28573145/cardio-ankle-vascular-index-and-indices-of-diabetic-polyneuropathy-in-patients-with-type-2-diabetes
#13
Akihiko Ando, Michiaki Miyamoto, Kazuhiko Kotani, Kenta Okada, Shoichiro Nagasaka, Shun Ishibashi
The cardio-ankle vascular index (CAVI) is used to test vascular function and is an arterial stiffness marker and potential predictor of cardiovascular events. This study aimed to analyze the relation between objective indices of diabetic polyneuropathy (DPN) and the CAVI. One hundred sixty-six patients with type 2 diabetes mellitus were included in this study. We used nerve conduction studies (NCSs) and the coefficient of variation of the R-R interval to evaluate DPN. We estimated arteriosclerosis by the CAVI...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28521198/clinical-characteristics-and-risk-factors-of-diabetic-peripheral-neuropathy-of-type-1-diabetes-mellitus-patients
#14
Xia Zhang, Chen Fang, Xiang Li, Yong-Jun Cao, Qi-Lin Zhang, Hong-Hong Zhang, Yun Huang, Ji Hu, Chun-Feng Liu
BACKGROUND: Small nerve fibers are more easily injured than large ones for diabetic peripheral neuropathy (DPN). The study investigated the characteristics and related risk factors of DPN of T1DM patients using nerve conduction velocity and CPT values, which provided evidences for its early diagnosis. METHODS: 70 T1DM patients and 48 healthy volunteers were included. All subjects accepted nerve conduction velocity and CPT examinations for four limbs. Detailed clinical indicators were recorded...
July 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28476051/impaired-corneal-sensation-and-nerve-loss-in-a-type-2-rat-model-of-chronic-diabetes-is-reversible-with-combination-therapy-of-menhaden-oil-%C3%AE-lipoic-acid-and-enalapril
#15
Eric P Davidson, Lawrence J Coppey, Hanna Shevalye, Alexander Obrosov, Randy H Kardon, Mark A Yorek
PURPOSE: This study investigated the efficacy of monotherapy versus combination of menhaden oil, α-lipoic acid, and enalapril on corneal sensation and morphometry and other neuropathy-related endpoints in a rat model of type 2 diabetes. METHODS: Male Sprague-Dawley rats (aged 12 weeks) were fed a high-fat diet for 8 weeks followed by 30 mg/kg streptozotocin. After 16 weeks of hyperglycemia, 12-week treatments consisting of menhaden oil, α-lipoic acid, enalapril, or their combination were initiated...
June 2017: Cornea
https://www.readbyqxmd.com/read/28442382/relationship-between-sensorimotor-peripheral-nerve-function-and-indicators-of-cardiovascular-autonomic-function-in-older-adults-from-the-health-aging-and-body-composition-study
#16
Brittney S Lange-Maia, Anne B Newman, John M Jakicic, Jane A Cauley, Robert M Boudreau, Ann V Schwartz, Eleanor M Simonsick, Suzanne Satterfield, Aaron I Vinik, Sasa Zivkovic, Tamara B Harris, Elsa S Strotmeyer
BACKGROUND: Age-related peripheral nervous system (PNS) impairments are highly prevalent in older adults. Although sensorimotor and cardiovascular autonomic function have been shown to be related in persons with diabetes, the nature of the relationship in general community-dwelling older adult populations is unknown. METHODS: Health, Aging and Body Composition participants (n=2399, age=76.5±2.9years, 52% women, 38% black) underwent peripheral nerve testing at the 2000/01 clinic visit...
October 1, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28427125/-the-clinical-value-of-sudoscan-in-diagnosis-of-diabetic-distal-symmetrical-peripheral-neuropathy
#17
J J Ma, S L Hao, X T Cheng, Y Yuan
Objective: To evaluate the clinical value of SUDOSCAN in diagnosis of diabetic distal symmetrical peripheral neuropathy. Methods: According to the diagnostic criteria for multiple diabetic distal symmetrical peripheral neuropathy, a total of 130 patients with type 2 diabetes mellitus (T2DM) in Department of Endocrinology, the Affiliated Hospital of Qingdao University between August 2015 and July 2016 were divided into two groups, diabetic peripheral neuropathy group (DPN group, 50 cases) and non-diabetic peripheral neuropathy group (NDPN group, 80 cases)...
April 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28421205/the-preferential-impairment-of-pupil-constriction-stimulated-by-blue-light-in-patients-with-type-2-diabetes-without-autonomic-neuropathy
#18
Fukashi Ishibashi, Rie Kojima, Miki Taniguchi, Aiko Kosaka, Harumi Uetake, Mitra Tavakoli
The main aim of the present paper is to examine whether the pupillary light reflex (PLR) mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) is impaired in type 2 diabetic patients. One hundred and three diabetic patients without diabetic autonomic neuropathy (DAN) and 42 age-matched controls underwent a series of detailed neurological examinations. The patients were stratified into three groups: stage I, no neuropathy; stage II, asymptomatic neuropathy; stage III, symptomatic but without DAN...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28393703/mir-106a-is-associated-with-diabetic-peripheral-neuropathy-through-the-regulation-of-12-15-lox-mediated-oxidative-nitrative-stress
#19
Yuanbo Wu, Dandan Xu, Xiang Zhu, Guangwei Yang, Mingshan Ren
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that with a complex pathogenesis. Study has reported that oxidative stress and nitrative stress were all involved in the DPN, however, the mechanism between them was still unclear. In the present study, we investigated whether miR-106a signaling regulated 12/15-Lipoxygenase (12/15-LOX) on oxidative/nitrative stress in DPN. METHODS: Dorsal root ganglion (DRG) was isolated from 10 healthy mice and 10 DPN mice...
April 4, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28357503/small-fibre-neuropathy-in-men-with-type-1-diabetes-and-erectile-dysfunction-a-cross-sectional-study
#20
Shazli Azmi, Maryam Ferdousi, Uazman Alam, Ioannis N Petropoulos, Georgios Ponirakis, Andrew Marshall, Omar Asghar, Hassan Fadavi, Wendy Jones, Mitra Tavakoli, Andrew J M Boulton, Maria Jeziorska, Handrean Soran, Nathan Efron, Rayaz A Malik
AIMS/HYPOTHESIS: The aim of this study was to identify the contribution of small- and large-fibre neuropathy to erectile dysfunction in men with type 1 diabetes mellitus. METHODS: A total of 70 participants (29 without and 41 with erectile dysfunction) with type 1 diabetes and 34 age-matched control participants underwent a comprehensive assessment of large- and small-fibre neuropathy. RESULTS: The prevalence of erectile dysfunction in participants with type 1 diabetes was 58...
June 2017: Diabetologia
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