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Iain G Thomson, Matthew P Wallen, Adrian Hall, Rebekah Ferris, David C Gotley, Andrew P Barbour, Andrew Lee, Janine Thomas, Bernard M Smithers
Neoadjuvant therapy (NAT) for oesophageal cancer may reduce cardiopulmonary function, assessed by cardiopulmonary exercise testing (CPEX). Impaired cardiopulmonary function is associated with mortality following esophagectomy. We sought to assess the impact of NAT on cardiopulmonary function using CPEX and assessing the clinical relevance of any change in particular if changes were associated with post-operative morbidity. This was a prospective, cohort study of 40 patients in whom CPEX was performed before and after NAT...
March 16, 2018: International Journal of Surgery
Tae Woong Hwang, Sung Ook Kim, Moon Sun Kim, So Ick Jang, Seong Ho Kim, Sang Yun Lee, Eun Young Choi, Su Jin Park, Hye Won Kwon, Hyo Bin Lim
BACKGROUND AND OBJECTIVES: The aim of this study was to investigate the effect of pulmonary valve replacement (PVR) on exercise capacity and determine cardiopulmonary exercise (CPEX) parameters associated with improvement in right ventricle (RV) function. SUBJECTS AND METHODS: We retrospectively analyzed CPEX and magnetic resonance imaging parameters in a total of 245 patients who underwent PVR from January 1998 to October 2015. In addition, we analyzed the characteristics of the patients who showed improved exercise capacity after PVR...
March 2017: Korean Circulation Journal
Balamugesh Thangakunam, Johnson Samuel, Basharet Ibrahim, Doug Aitchison
BACKGROUND: The thoracic surgery scoring system (Thoracoscore) is a multivariate scoring system with nine parameters used for predicting inpatient mortality after thoracic surgery. In clinical practice, the value of the thoracoscore in evaluating the fitness of individual patients for surgery is not clear. OBJECTIVE: The study objective was to evaluate the performance of thoracoscore in evaluating fitness for surgery for lung cancer and compare it with cardiopulmonary exercise test (CPEX)...
January 2015: Indian Journal of Chest Diseases & Allied Sciences
K A Gilbert, A J Hogarth, W MacDonald, N T Lewis, L B Tan, M H Tayebjee
BACKGROUND: The improvement in cardiac physiological parameters after restoration of sinus rhythm in patients with persistent atrial fibrillation (AF) can be challenging to quantify. Overall cardiac function assessment is better assessed by peak cardiac power output (CPOpeak), rather than indirect measures of cardiac performance such as peak oxygen consumption (VO2peak). CPO was used to quantify improvement in cardiac function early and later following electrical cardioversion. METHODS AND RESULTS: 29 patients with persistent AF underwent maximal treadmill cardiopulmonary exercise (CPEx) testing within 14days (±3) 8weeks (±3) following electrical cardioversion (DCCv)...
November 15, 2015: International Journal of Cardiology
Paul Hiles, William Porr, Joseph Abraham, Michael Morris
SESSION TYPE: Occupational/ Environmental Lung DiseasePRESENTED ON: Tuesday, October 23, 2012 at 04:30 PM - 05:45 PMPURPOSE: The purpose of this study was to investigate differences in cardiopulmonary exercise (CPEX) testing between deployed vs. non-deployed military personnel undergoing a clinical evaluation for dyspnea.METHODS: A retrospective review was conducted of all CPEX studies performed at our institution on active duty military personnel during a clinical evaluation for dyspnea. All CPEX studies had been performed on a bicycle ergometer to maximum exercise tolerance...
October 1, 2012: Chest
Carla M Plymen, Dan M Sado, Andrew M Taylor, Aidan P Bolger, Pier D Lambiase, Marina Hughes, James C Moon
AIMS: After atrial redirection surgery (Mustard-Senning operations) for transposition of the great arteries (TGA), the systemic right ventricle (RV) suffers from late systolic failure with high morbidity and mortality. Mechanisms of late RV failure are poorly characterized. We hypothesized that diffuse interstitial expansion representing diffuse fibrosis is greater in systemic RVs of patients following Mustard-Senning surgery and that it would be associated with other markers of heart failure and disease severity...
October 2013: European Heart Journal Cardiovascular Imaging
C E Western, J Carlisle, R J McCarthy, I C Currie
OBJECTIVES: To establish outcome of patients with abdominal aortic aneurysm (AAA) deemed unfit for repair. DESIGN: Retrospective non-randomised study. MATERIALS AND METHODS: Identification of males with >5.5 cm or females with >5.0 cm AAA turned down for elective repair between 01/01/2006-24/07/2009 from a prospective database. Comorbidities, reasons for non-intervention, aneurysm size, survival, use of CPEX (cardio-pulmonary exercise) testing and cause of death were analysed...
January 2013: European Journal of Vascular and Endovascular Surgery
Lisbeth Illum
The present review sets out to discuss recent developments and prospects of absorption promoters and absorption modulator systems being developed commercially by companies specialising in nasal drug delivery of normal small molecular weight drugs and biological drugs such as peptide and proteins. The absorption promoter systems selected for discussion in this review are those with the most promising preclinical and/or clinical data and sufficient toxicology data and/or company development efforts to warrant use in marketed products i...
July 20, 2012: Journal of Controlled Release: Official Journal of the Controlled Release Society
Robert Stote, Michael Miller, Thomas Marbury, Leon Shi, Poul Strange
BACKGROUND: This pharmacokinetic (PK) study was designed to investigate the maximum intranasal insulin dose that could be achieved by repeated doses in a single nostril of a nasal spray of recombinant regular human insulin 1% in combination with cyclopentadecalactone (CPE-215) 2%, a compound that enhances absorption of molecules across mucous membranes (Nasulin™, CPEX Pharmaceuticals, Inc.). METHOD: A nine-period crossover study of 8 healthy, nonsmoking subjects (ages 18-50, body mass index <33 kg/m², weight >70 kg) were studied...
January 1, 2011: Journal of Diabetes Science and Technology
Robert Stote, Thomas Marbury, Leon Shi, Michael Miller, Poul Strange
BACKGROUND: This pharmacokinetic (PK) study was designed to characterize the dose response of two concentrations (0.7% and 1%) of a nasal spray of recombinant regular human insulin in combination with cyclopentadecalactone (CPE-215), a compound that enhances absorption of molecules across mucous membranes (Nasulin, CPEX Pharmaceuticals). Nasulin has been effective in lowering blood glucose in both normal subjects and diabetes patients, and additional dosing options would allow greater titration flexibility...
May 1, 2010: Journal of Diabetes Science and Technology
Niro Okimoto, Kenji Yamato, Yoshihiro Honda, Takeyuki Kurihara, Kohichi Osaki, Naoko Asaoka, Kazue Fujita, Hideo Ohba
The effect of intravenous ciprofloxacin (CPFX) on hospital-acquired pneumonia was examined. The subjects were 32 patients with hospital-acquired pneumonia classified as being in group I, group II, and group III, based on The Japanese Respiratory Society Guidelines for management of hospital-acquired pneumonia. None of the patients had received antibiotic treatment for the pneumonia. CPFX 300 mg was intravenously infused twice daily for 3-14 days, and its clinical effect, bacterological effect, and side effects were examined...
February 2005: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
G B Tirdel, R Girgis, R S Fishman, J Theodore
BACKGROUND: Cardiopulmonary exercise (CPEx) studies of lung transplant (LTx) recipients have found low maximum oxygen consumptions because of an as yet unexplained mechanism. Although it is likely that a significant problem resides within the mitochondria, this study determines whether a defect in oxygen uptake or utilization is present. METHODS: Six LTx recipients and six age- and sex-matched, healthy control subjects were studied to assess the possibility of a mitochondrial myopathy in LTx recipients...
December 1998: Journal of Heart and Lung Transplantation
A E Lyubarev, B I Kurganov
The model of thermal protein denaturation involving two consecutive irreversible steps has been analyzed. The equation describing the dependence of excess heat capacity (Cpex) on temperature (T) under a constant scanning rate has been obtained and used for construction of theoretical Cpex versus T profiles. The change in the shape of theoretical profiles at varied Arrhenius equation parameters, ratio for enthalpies of the first and second steps, and the scanning rate have been studied. It has been shown that formal use of one-step model does not provide adequate information about kinetic features of the process in the case of protein denaturation following the mechanism involving two consecutive irreversible steps...
April 1998: Biochemistry. Biokhimii︠a︡
D A Mahler, M J Franco
Noninvasive measurement of metabolic and cardiorespiratory variables can be readily obtained using computerized systems as part of exercise testing of patients on a cycle ergometer or treadmill. The major indications for CPEX are: to assess exercise-related symptoms, especially dyspnea and chest pain; to measure exercise capacity including acceptability of patients with end-stage heart disease for cardiac transplantation; to evaluate for impairment/disability; to establish safety and guidelines for exercise training; and to assess response to specific therapy...
November 1996: Journal of Cardiopulmonary Rehabilitation
W Y Chen, F N Ko, C N Lin, C M Teng
A synthetic xanthone derivative, 3-[2-(cyclopropylamino)ethoxy] xanthone (CPEX), was investigated for its antiplatelet activities in washed rabbit platelets and human platelet-rich plasma. CPEX inhibited concentration-dependently the aggregation and ATP release of rabbit platelets caused by arachidonic acid (AA; 100 microM) and collagen (10 micrograms/ml), but not those by thrombin (0.1 U/ml), PAF (2 ng/ml), and U46619 (1 microM). The IC50 value of CPEX on AA-induced aggregation was 10.9 +/- 2.1 microM (n = 7)...
July 1, 1994: Thrombosis Research
R S Fishman, D M Systrom
Over the past 15 years evaluation of the patient with exertional complaints has changed from a simple qualitative estimate of overall fitness to a detailed assessment of cardiovascular and pulmonary pathophysiology. By quantifying exercise impairment and identifying the physiological limit to exercise, CPEx can help direct and evaluate the efficacy of medical and surgical interventions. Although no clear consensus has emerged, an objective determination of the etiology of exercise intolerance may also help identify the patient at increased risk for postthoracotomy complications...
December 1991: Journal of Cardiothoracic and Vascular Anesthesia
J Nishi, M Yoshinaga, A Mogi, K Matsuyama, S Aihoshi, K Miyata, H Miyanohara, S Otsuji
Susceptibility to antibiotics of 123 MRSA strains isolated at the Kagoshima University Hospital in 1989 was examined. The results were as follows: 1) Susceptibility of MRSA strains was excellent to VCM, MINO, and RFP, followed by IMP, CLDM, and CPFX. However, most strains were resistant to PCG, MPIPC, ABPC, CET, CMZ, CZON, GM, and AMK. 2) Five strains highly resistant to RFP were isolated. Three of these strains were isolated on the ward for tuberculosis. This suggests easy development of resistance to RFP by MRSA...
September 1991: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
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