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https://www.readbyqxmd.com/read/29050390/involvement-of-fast-spiking-cells-in-ictal-sequences-during-spontaneous-seizures-in-rats-with-chronic-temporal-lobe-epilepsy
#1
Adam R Neumann, Robrecht Raedt, Hendrik W Steenland, Mathieu Sprengers, Katarzyna Bzymek, Zaneta Navratilova, Lilia Mesina, Jeanne Xie, Valerie Lapointe, Fabian Kloosterman, Kristl Vonck, Paul A J M Boon, Ivan Soltesz, Bruce L McNaughton, Artur Luczak
See Lenck-Santini (doi:10.1093/awx205) for a scientific commentary on this article. Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution and cellular substrates of the neuronal activity patterns associated with spontaneous seizures are not fully understood. We used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rats with chronic temporal lobe epilepsy to demonstrate that subsets of cells discharge in a highly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were reproducible across consecutive seizures...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050359/next-generation-sequencing-in-chronic-lymphocytic-leukemia-recent-findings-and-new-horizons
#2
REVIEW
Ana E Rodríguez-Vicente, Vasilis Bikos, María Hernández-Sánchez, Jitka Malcikova, Jesús-María Hernández-Rivas, Sarka Pospisilova
The rapid progress in next-generation sequencing technologies has significantly contributed to our knowledge of the genetic events associated with the development, progression and treatment resistance of chronic lymphocytic leukemia patients. Together with the discovery of new driver mutations, next-generation sequencing has revealed an immense degree of both intra- and inter-tumor heterogeneity and enabled us to describe marked clonal evolution. Advances in immunogenetics may be implemented to detect minimal residual disease more sensitively and to track clonal B cell populations, their dynamics and molecular characteristics...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050309/fibronectin-in-cell-adhesion-and-migration-via-n-glycosylation
#3
Cheng-Te Hsiao, Hung-Wei Cheng, Chi-Ming Huang, Hao-Ru Li, Meng-Hsin Ou, Jie-Rong Huang, Kay-Hooi Khoo, Helen Wenshin Yu, Yin-Quan Chen, Yang-Kao Wang, Arthur Chiou, Jean-Cheng Kuo
Directed cell migration is an important step in effective wound healing and requires the dynamic control of the formation of cell-extracellular matrix interactions. Plasma fibronectin is an extracellular matrix glycoprotein present in blood plasma that plays crucial roles in modulating cellular adhesion and migration and thereby helping to mediate all steps of wound healing. In order to seek safe sources of plasma fibronectin for its practical use in wound dressing, we isolated fibronectin from human (homo) and porcine plasma and demonstrated that both have a similar ability as a suitable substrate for the stimulation of cell adhesion and for directing cell migration...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050288/the-protective-effects-of-polysaccharide-of-atractylodes-macrocephala-koidz-pamk-on-the-chicken-spleen-under-heat-stress-via-antagonizing-apoptosis-and-restoring-the-immune-function
#4
Danning Xu, Bingxin Li, Nan Cao, Wanyan Li, Yunbo Tian, Yunmao Huang
Heat stress can cause immune organ dysfunction and apoptosis. Polysaccharide of Atractylodes macrocephala Koidz may have protective effects on immune organs. In this study, we established chicken models of Polysaccharide of Atractylodes macrocephala Koidz-heat stress interaction and detected the oxidative index, activities of mitochondrial complexes and ATPases as well as the ultrastructure in chicken spleens. Expression levels of cytokines, mitochondrial dynamics- and apoptosis-related genes were also measured...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050027/new-preventive-approaches-part-ii-role-of-dentin-biomodifiers-in-caries-progression
#5
Ana K Bedran-Russo, Camila A Zamperini
Dental caries is the most prevalent infectious chronic disease in children and adults. With a globally aging population, new demands in the management of dental caries are awakened by the rampant increase in the incidence of dental root caries. Like crown caries, root caries requires bacterial driven tissue demineralization followed by the degradation of the extracellular dentin matrix. Due to the complex composition and ultrastructure, preventive strategies targeting the mineral phase of dentin are insufficient for managing the prevention and progression of root caries...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29050008/response-of-the-endothelium-to-the-epicutaneous-application-of-leukotriene-b4
#6
Sabina C A Hanssen, Anke G M Hendriks, Romy M C Keijsers, Piet E J van Erp, Carine J M van der Vleuten, Marieke M B Seyger, Peter C M van de Kerkhof
BACKGROUND: Vascular changes, both endothelial and functional, are crucial events in inflammatory responses. OBJECTIVES: To investigate the dynamics of endothelial cell (EC) and functional changes during acute inflammation in an in vivo model of the skin using leukotriene B4. METHODS: EC proliferation, vascular network size, vessel diameter (VD), and hypoxia-inducible factor (HIF)-1α were studied by immunohistochemical CD31/Ki67 double staining and single staining of HIF-1α...
October 20, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29049959/excretion-pattern-and-dynamics-of-glutathione-detoxification-of-microcystins-in-sprague-dawley-rat
#7
Wei Li, Jun He, Jun Chen, Ping Xie
The excretion route and dynamics of the glutathione (GSH) conjugate of microcystin-RR (MCRR), MCRR-GSH, were quantitatively studied in Sprague Dawley rat exposed with MCRR-GSH via liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS). In the MCRR-GSH-treated rat, the average MCRR-Cysteine (MCRR-Cys)/MCRR-GSH ratio reached as high as 105.3, which indicated that the intermediate conjugate MCRR-GSH was rapidly converted to the product compound MCRR-Cys. Besides, MCRR was consistently detected in MCRR-GSH-treated rat, which suggested that MCRR can be dissociated from the MCRR-GSH conjugate and the reversibility of the MC-GSH conjugate...
September 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/29049952/learn-from-microbial-intelligence-for-avermectins-overproduction
#8
REVIEW
Qiang Gao, Gao-Yi Tan, Xuekui Xia, Lixin Zhang
Microbial strains are amazingly clever by homeostasis of their own survival and optimization for the overproduction of a desired phenotype, for example drugable secondary metabolites through coordination of key genes overexpression and media optimizations. Besides their pesticide activities, avermectins (AVMs) are identified as potent antibiotic agents for a wide range of drug-resistant pathogens by a high-throughput synergy screening strategy. To rewire the genetic circuitry controlling low yields, we summarized the work on balancing the biological chassis with functional parts, and optimized their dynamical process, as well as predicted favorable effective overproduction of AVMs by 5Ms strategy...
October 16, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29049910/an-improved-synchronization-likelihood-method-for-quantifying-neuronal-synchrony
#9
Sina Khanmohammadi
Indirect quantification of the synchronization between two dynamical systems from measured experimental data has gained much attention in recent years, especially in the computational neuroscience community where the exact model of the neuronal dynamics is unknown. In this regard, one of the most promising methods for quantifying the interrelationship between nonlinear non-stationary systems is known as Synchronization Likelihood (SL), which is based on the likelihood of the auto-recurrence of embedding vectors (similar patterns) in multiple dynamical systems...
October 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29049887/all-atom-molecular-dynamics-based-analysis-of-membrane-stabilizing-copolymer-interactions-with-lipid-bilayers-probed-under-constant-surface-tensions
#10
Evelyne M Houang, Frank S Bates, Yuk Yin Sham, Joseph M Metzger
An all-atom phospholipid bilayer and triblock copolymer model was developed for Molecular Dynamics (MD) studies. These were performed to investigate the mechanism of interaction between membrane stabilizing triblock copolymer P188 and 1-palmitoyl-2-oleoyl-sn- glycero-3-phosphatidylcholine (POPC) lipid bilayers under applied lateral surface tension (γ) to model membrane mechanical stress. Results showed that P188 insertion is driven by the hydrophobic polypropylene oxide (PPO) core and dependent on bilayer area per lipid...
October 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29049883/rotational-spectroscopy-of-p-toluic-acid-and-its-1-1-complex-with-water
#11
Elijah G Schnitzler, Nathan A Seifert, Ignes Kusuma, Wolfgang Jaeger
The structure and internal dynamics of p-toluic acid and its 1:1 complex with water were investigated in the gas phase using chirped-pulse and cavity-based Fourier transform microwave spectroscopy. One conformer and one isomer were identified for the monomer and monohydrate, respectively. In the monohydrate, water acts as both a hydrogen bond donor and acceptor, participating in a six-membered intermolecular ring with the carboxyl group. Both a- and b-type transitions were observed for the monomer; only a-type transitions were observed for the monohydrate...
October 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29049871/a-table-top-pxi-based-low-field-spectrometer-for-solution-dynamic-nuclear-polarization
#12
Joshua R Biller, Karl F Stupic, J Moreland
We present the development of a portable dynamic nuclear polarization (DNP) instrument based on the PCI eXtensions for Instrumentation (PXI) platform. The main purpose of the instrument is for study of (1) H polarization enhancements in solution through the Overhauser mechanism at low magnetic fields. A DNP probe set was constructed for use at 6.7 mT, using a modified Alderman-Grant (MAG) resonator at 241 MHz for saturation of the electron transition. The solenoid for detection of the enhanced (1) H signal at 288 kHz was constructed with Litz wire...
October 19, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29049867/ion-pair-and-solvation-dynamics-of-bmim-bf4-water-system
#13
João Cascão, Wagner Silva, Ana S D Ferreira, Eurico J Cabrita
In this work, [Bmim][BF4 ]/water mixtures were analysed over the whole water composition (xw ) in order to study the rotational and translational behaviour of the ions. We employed a multinuclear NMR approach to determine anion/cation/water diffusion coefficients and longitudinal relaxation rates at different water content. In neat IL the cation diffuses faster than the anion and at low xw anions and cations share almost the same diffusion coefficient, but above a critical water concentration the anion begins to diffuse faster than the cation...
October 19, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29049865/interrogating-membrane-protein-conformational-dynamics-within-native-lipid-compositions
#14
Eamonn Reading, Zoe Hall, Chloe Martens, Tabasom Haghighi, Heather Findlay, Zainab Ahdash, Argyris Politis, Paula J Booth
Membrane protein-lipid interplay is important for cellular function, however, tools enabling the interrogation of protein dynamics within native lipid environments are scarce and often invasive. We establish that the styrene-maleic acid anhydride lipid particle (SMALP) technology can be coupled with hydrogen-deuterium exchange mass spectrometry (HDX-MS) to investigate membrane protein conformational dynamics within native lipid bilayers. We demonstrate changes in accessibility and dynamics of the rhomboid protease, GlpG, captured within three different native lipid compositions, and identify protein regions sensitive to changes in the native lipid environment...
October 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29049853/nutrient-driven-o-glcnac-in-proteostasis-and-neurodegeneration
#15
REVIEW
Ilhan Akan, Stephanie Olivier-Van Stichelen, Michelle R Bond, John A Hanover
Proteostasis is essential in the mammalian brain where post-mitotic cells must function for decades to maintain synaptic contacts and memory. The brain is dependent on glucose and other metabolites for proper function and is spared from metabolic deficits even during starvation. In this review, we outline how the nutrient sensitive nucleocytoplasmic posttranslational modification O-linked N-acetylglucosamine (O-GlcNAc) regulates protein homeostasis. The O-GlcNAc modification is highly abundant in the mammalian brain, and has been linked to proteopathies, including neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's...
October 19, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29049727/the-diameter-of-retinal-vessels-is-affected-by-transient-ischemia-of-the-arm-in-normal-persons
#16
Yasmin El Dabagh, Line Petersen, Michael Pedersen, Toke Bek
Purpose: Remote ischemic conditioning (RIC) implies that transient ischemia in a limb can affect perfusion in a target organ elsewhere in the body. The changes in perfusion can be assumed to be paralleled by changes in the vessel diameters in the target organ. It remains to be elucidated whether the diameter of normal retinal vessels can be used as a marker of RIC in vivo. Methods: In 20 normal persons aged 20 to 31 years the Dynamic Vessel Analyzer (DVA) was used to measure the resting diameter and diameter changes during isometric exercise and flicker stimulation before, immediately after, and 1 hour after RIC induced by transient ischemia in the left arm...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049701/effects-of-blood-flow-dynamics-on-autologous-pericardial-degeneration-in-reconstructed-pulmonary-arteries
#17
Nobuyasu Kato, Masaaki Yamagishi, Keiichi Itatani, Takako Miyazaki, Yoshinobu Maeda, Satoshi Asada, Yoshiro Matsui, Hitoshi Yaku
OBJECTIVES: To clarify the risk factors for abnormal degeneration of autologous pericardium, the mechanical stress on the endothelial tissue caused by turbulent blood flow in the pulmonary artery (PA) reconstructed with autologous pericardium and major aortopulmonary collateral arteries was assumed in pulmonary atresia and ventricular septal defect. METHODS: Patient-specific PA models were created for 6 patients based on their past computed tomography images taken after unifocalization of major aortopulmonary collateral arteries...
October 12, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049629/do-older-listeners-with-hearing-loss-benefit-from-dynamic-pitch-for-speech-recognition-in-noise
#18
Jing Shen, Pamela E Souza
Purpose: Dynamic pitch, the variation in the fundamental frequency of speech, aids older listeners' speech perception in noise. It is unclear, however, whether some older listeners with hearing loss benefit from strengthened dynamic pitch cues for recognizing speech in certain noise scenarios and how this relative benefit may be associated with individual factors. We first examined older individuals' relative benefit between natural and strong dynamic pitches for better speech recognition in noise...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049594/the-perceptual-dimensions-of-natural-dynamic-flow
#19
Yaniv Morgenstern, Daniel J Kersten
We measured perceptual judgments of category, material attributes, affordances, and similarity to investigate the perceptual dimensions underlying the visual representation of a broad class of natural dynamic flows (sea waves, smoke, and windblown foliage). The dynamic flows were looped 3-s movies windowed with circular apertures of two sizes to manipulate the level of spatial context. In low levels of spatial context (smaller apertures), human observers' judgments of material attributes and affordances were inaccurate, with estimates biased toward assumptions that the flows resulted from objects that were rigid, "pick-up-able," and not penetrable...
October 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/29049474/virtual-surgery-for-the-nasal-airway-a-preliminary-report-on-decision-support-and-technology-acceptance
#20
Derek L Vanhille, Guilherme J M Garcia, Onur Asan, Azadeh A T Borojeni, Dennis O Frank-Ito, Julia S Kimbell, Sachin S Pawar, John S Rhee
Importance: Nasal airway obstruction (NAO) is a common problem that affects patient quality of life. Surgical success for NAO correction is variable. Virtual surgery planning via computational fluid dynamics (CFD) has the potential to improve the success rates of NAO surgery. Objective: To elicit surgeon feedback of a virtual surgery planning tool for NAO and to determine if this tool affects surgeon decision making. Design, Setting, and Participants: For this cross-sectional study, 60-minute face-to-face interviews with board-certified otolaryngologists were conducted at a single academic otolaryngology department from September 16, 2016, through October 7, 2016...
October 12, 2017: JAMA Facial Plastic Surgery
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