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https://www.readbyqxmd.com/read/29452435/dynamic-lumen-obstructing-angulation-in-advanced-sigmoid-type-achalasia-successfully-treated-by-additional-proximal-curve-myotomy
#1
Stefan Seewald, Tiing Leong Ang, Michael Patak, Karl Yu Kim Teng, Haruhiro Inoue
No abstract text is available yet for this article.
February 16, 2018: Endoscopy
https://www.readbyqxmd.com/read/29452420/gut-microbiomics-a-solution-to-unloose-the-gordian-knot-of-biological-effects-of-ionizing-radiation
#2
Amy Zhang, Tomoko Y Steen
The Chernobyl and Fukushima nuclear accidents have called forth a growing body of research on their biological aftermaths. A variety of wild organisms, including primates, birds, fish, insects, and worms are being studied in the affected areas, with emerging morphological, physiological, and genetic aberrations ascribed to ionizing radiation. Despite the effort in surveying Chernobyl and Fukushima wildlife, little is known about the microorganisms associated with these radiation-contaminated animals. The microbiota, especially the gut commensal, plays an important role in shaping the metabolic reservoir and immune system of the host, and is sensitive to a wide array of environmental factors, including ionizing radiation...
February 14, 2018: Journal of Heredity
https://www.readbyqxmd.com/read/29452385/longitudinal-tobacco-use-transitions-among-adolescents-and-young-adults-2014-2016
#3
Elizabeth C Hair, Alexa R Romberg, Raymond Niaura, David B Abrams, Morgane A Bennett, Haijun Xiao, Jessica M Rath, Lindsay Pitzer, Donna Vallone
Introduction: Among youth, the frequency and prevalence of using more than one tobacco (small cigar, cigarette, and hookah) or nicotine-containing product (e-cigarettes-ENDS) are changing. These shifts pose challenges for regulation, intervention, and prevention campaigns because of scant longitudinal data on the stability of use patterns in this changing product landscape. Methods: A nationally representative longitudinal survey of 15- to 21-year olds (n = 15,275) was used to describe transitions between never use, noncurrent use, and past 30-day use of combustible tobacco, e-cigarettes (ENDS), and dual use of both kinds of products...
February 13, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29452383/the-effectiveness-of-asian-bush-mosquito-aedes-japonicus-japonicus-control-actions-in-colonised-peri-urban-areas-in-the-netherlands
#4
A Ibañez-Justicia, S Teekema, W den Hartog, F Jacobs, M Dik, A Stroo
The Asian bush mosquito (Aedes japonicus japonicus (Theobald)) is an invasive mosquito species in Europe. In 2012, it was for the first time detected in the Netherlands, in the municipality of Lelystad. After further research, thousands of specimens were found in the surrounding peri-urban areas of the city. A targeted mosquito control campaign began in 2015 with the objective of reducing populations in locations with the highest concentrations of Ae. japonicus breeding sites: allotment garden complexes. Mosquito control consisted of source reduction combined with application of the larvicide Vectomax in breeding sites...
February 14, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29452382/simulated-ablation-for-detection-of-cells-impacting-paracrine-signalling-in-histology-analysis
#5
Jake P Taylor-King, Etienne Baratchart, Andrew Dhawan, Elizabeth A Coker, Inga Hansine Rye, Hege Russnes, S Jon Chapman, David Basanta, Andriy Marusyk
Intra-tumour phenotypic heterogeneity limits accuracy of clinical diagnostics and hampers the efficiency of anti-cancer therapies. Dealing with this cellular heterogeneity requires adequate understanding of its sources, which is extremely difficult, as phenotypes of tumour cells integrate hardwired (epi)mutational differences with the dynamic responses to microenvironmental cues. The later comes in form of both direct physical interactions, as well as inputs from gradients of secreted signalling molecules. Furthermore, tumour cells can not only receive microenvironmental cues, but also produce them...
February 14, 2018: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/29452376/the-vacuolar-transportome-of-plant-specialized-metabolites
#6
Rita de Brito Francisco, Enrico Martinoia
The plant vacuole is a cellular compartment that is essential to plant development and growth. Often plant vacuoles accumulate specialized metabolites, also called secondary metabolites, which constitute functionally and chemically diverse compounds that exert in planta many essential functions and improve the plant's fitness. These metabolites provide for example chemical defence against herbivorous and pathogens or chemical attractants (colour and fragrance) to attract pollinators. The chemical composition of the vacuole is dynamic and is altered during development and as a response to environmental changes...
February 14, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29452282/load-sharing-through-elastic-micro-motion-accelerates-bone-formation-and-interbody-fusion
#7
Eric H Ledet, Glenn P Sanders, Darryl J DiRisio, Joseph C Glennon
BACKGROUND: Context: Achieving a successful spinal fusion requires the proper biologic and biomechanical environment. Optimizing load-sharing in the interbody space can enhance bone formation. For anterior cervical discectomy and fusion (ACDF), loading and motion are largely dictated by the stiffness of the plate which can facilitate a balance between stability and load-sharing. The advantages of load-sharing may be substantial for patients with comorbidities and in multi-level procedures where pseudarthrosis rates are significant...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29452279/biophysical-methods-complementary-tools-to-study-the-influence-of-human-steroid-hormones-on-the-liposome-membrane-properties
#8
REVIEW
Rola Abboud, Catherine Charcosset, Hélène Greige-Gerges
Human steroid hormones are involved in many aspects of physiology and have long been known to exert rapid and delayed effects. They are lipophilic molecules which can be incorporated into the lipid membranes. Through non-covalent interactions they can alter the properties of the membrane, including fluidity, lipid raft formation and others. In this review, different biophysical techniques were described to study the interaction of human steroid hormones with biological and biomimetic membranes such as differential scanning calorimetry, electron paramagnetic resonance, fluorescence spectroscopy and Fourier transform infrared spectroscopy...
February 13, 2018: Biochimie
https://www.readbyqxmd.com/read/29452267/git2-a-keystone-in-ageing-and-age-related-disease
#9
REVIEW
Jaana van Gastel, Jan Boddaert, Areta Jushaj, Richard T Premont, Louis M Luttrell, Jonathan Janssens, Bronwen Martin, Stuart Maudsley
Since its discovery, G protein-coupled receptor kinase-interacting protein 2, GIT2, and its family member, GIT1, have received considerable interest concerning their potential key roles in regulating multiple inter-connected physiological and pathophysiological processes. GIT2 was first identified as a multifunctional protein that is recruited to G protein-coupled receptors (GPCRs) during the process of receptor internalization. Recent findings have demonstrated that perhaps one of the most important effects of GIT2 in physiology concerns its role in controlling multiple aspects of the complex ageing process...
February 13, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29452199/establishment-of-the-nasal-microbiota-in-the-first-18-months-of-life-correlation-with-early-onset-rhinitis-and-wheezing
#10
Le Duc Huy Ta, Gaik Chin Yap, Carina Jing Xuan Tay, Alicia Shi Min Lim, Chiung Hui Huang, Collins Wenhan Chu, Paola Florez De Sessions, Lynette P Shek, Anne Goh, Hugo P S Van Bever, Oon Hoe Teoh, Jian Yi Soh, Biju Thomas, Mahesh Babu Ramamurthy, Daniel Y T Goh, Christophe Lay, Shu-E Soh, Yiong Huak Chan, Seang-Mei Saw, Kenneth Kwek, Yap-Seng Chong, Keith M Godfrey, Martin Lloyd Hibberd, Bee Wah Lee
BACKGROUND: The dynamic establishment of the nasal microbiota in early life influences local mucosal immune responses and the susceptibility to childhood respiratory disorders. OBJECTIVE: The aim of this case-control study was to monitor, evaluate and compare the development of the nasal microbiota of infants who developed rhinitis and wheeze in the first 18 months of life with those of healthy controls. METHODS: Anterior nasal swabs of 122 subjects belonging to the GUSTO birth cohort were collected longitudinally over seven time points in the first 18 months of life...
February 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29452174/dynamics-analysis-of-epidemic-and-information-spreading-in-overlay-networks
#11
Guirong Liu, Zhimei Liu, Zhen Jin
We establish an SIS-UAU model to present the dynamics of epidemic and information spreading in overlay networks. The overlay network is represented by two layers: one where the dynamics of the epidemic evolves and another where the information spreads. We theoretically derive the explicit formulas for the basic reproduction number of awareness R 0 a by analyzing the self-consistent equation and the basic reproduction number of disease R 0 d by using the next generation matrix. The formula of R 0 d shows that the effect of awareness can reduce the basic reproduction number of disease...
February 13, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29452172/joint-evolution-of-dispersal-propensity-and-site-selection-in-structured-metapopulation-models
#12
Tuomas Nurmi, Kalle Parvinen, Vesa Selonen
We propose a novel mathematical model for a metapopulation in which dispersal occurs on two levels: juvenile dispersal from the natal site is mandatory but it may take place either locally within the natal patch or globally between patches. Within each patch, individuals live in sites. Each site can be inhabited by at most one individual at a time and it may be of high or low quality. A disperser immigrates into a high-quality site whenever it obtains one, but it immigrates into a low-quality site only with a certain probability that depends on the time within the dispersal season...
February 13, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29452169/expression-patterns-of-toll-like-receptor-tlr-2-tlr-4-and-myeloid-differentiation-primary-response-gene-88-myd88-in-renal-transplant-patients-developing-allograft-dysfunction-a-cohort-study
#13
Morteza Hosseinzadeh, Pedram Ahmadpoor, Mir Saeed Yekaninejad, Fatemeh Pourrezagholi, Farshad Foroughi, Mina Ghorbanpour, Mehri Barabadi, Sanaz K Shahbaz, Ghasem Solgi, Aliakbar Amirzargar
This cohort intends to determine the sequential dynamic changes in Toll-like receptor (TLR)-4, TLR-2, and myeloid differentiation primary response gene 88 (MYD88) mRNA expressions in PBMCs and biopsy samples from kidney allograft recipients in relation to graft function. This study enrolled 52 renal transplant patients, 27 with well functioning graft (WFG) and 25 graft dysfunction (GD). Peripheral blood samples pre- and post-transplantation (days 2, 90 and 180) were collected to analyze mRNA expression levels of TLR-2, TLR-4, and MYD88 genes in relation to allograft function during one-year follow up...
February 13, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29452155/comparative-developmental-biology-of-the-cardiac-inflow-tract
#14
REVIEW
Rita Carmona, Laura Ariza, Ana Cañete, Ramón Muñoz-Chápuli
The vertebrate heart receives the blood through the cardiac inflow tract. This area has experienced profound changes along the evolution of vertebrates; changes that have a reflection in the cardiac ontogeny. The development of the inflow tract involves dynamic changes due to the progressive addition of tissue derived from the secondary heart field. The inflow tract is the site where oxygenated blood coming from lungs is received separately from the systemic return, where the cardiac pacemaker is established and where the proepicardium develops...
February 13, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29452078/ice-free-cryopreservation-of-heart-valve-tissue-the-effect-of-adding-mitoq-to-a-vs83-formulation-and-its-influence-on-mitochondrial-dynamics
#15
Yulong Sui, Qing Fan, Bin Wang, Jixian Wang, Qing Chang
No abstract text is available yet for this article.
February 13, 2018: Cryobiology
https://www.readbyqxmd.com/read/29452027/short-interval-overnight-laser-scanning-suggest-sub-circadian-periodicity-of-tree-turgor
#16
András Zlinszky, Anders Barfod
A recent study by Zlinszky et al., 1 uses high-resolution terrestrial laser scanning to investigate the variability of overnight movement of leaves and branches in vascular plants. This study finds among others that the investigated plants show periodic movements of around one centimetre in amplitude and 2-6 hour periodicity. Sub-circadian process dynamics of plants were so far not in focus of research, but here we compare the findings with other published cases of short-term periodicity in leaf turgor, sap flow and especially trunk diameter...
February 16, 2018: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29451962/nucleopeptide-assemblies-selectively-sequester-atp-in-cells
#17
Huaimin Wang, Zhaoqianqi Feng, Yanan Qin, Jiaqing Wang, Bing Xu
Here we report that assemblies of nucleopeptides selectively sequestrate ATP in complex conditions (e.g., serum and cytosol). We develop assemblies of nucleopeptides that selectively sequester ATP over ADP. Counteracting enzymes interconvert ATP and ADP to modulate the nanostructures formed by the nucleopeptides and the nucleotides. The nucleopeptides, sequestering ATP effectively in cells, slow down efflux pumps in multidrug resistance cancer cells, thus boosting the efficacy of an anticancer drug. Examining additional 11 nucleopeptides (including D- and L-enantiomers) yields five more nucleopeptides that differentiate ATP and ADP via either precipitation or gelation...
February 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29451901/the-novel-antibiotic-rhodomyrtone-traps-membrane-proteins-in-vesicles-with-increased-fluidity
#18
Dennapa Saeloh, Varomyalin Tipmanee, Kin Ki Jim, Marien P Dekker, Wilbert Bitter, Supayang P Voravuthikunchai, Michaela Wenzel, Leendert W Hamoen
The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose myrtle Rhodomyrtus tomentosa, a plant used in Asian traditional medicine. While many studies have demonstrated its antibacterial potential in a variety of clinical applications, very little is known about the mechanism of action of rhodomyrtone. Preceding studies have been focused on intracellular targets, but no specific intracellular protein could be confirmed as main target. Using live cell, high-resolution, and electron microscopy we demonstrate that rhodomyrtone causes large membrane invaginations with a dramatic increase in fluidity, which attract a broad range of membrane proteins...
February 16, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29451899/cooperation-enhanced-by-the-coevolution-of-teaching-activity-in-evolutionary-prisoner-s-dilemma-games-with-voluntary-participation
#19
Chen Shen, Chen Chu, Yini Geng, Jiahua Jin, Fei Chen, Lei Shi
Voluntary participation, as an additional strategy involved in repeated games, has been proved to be an efficient way to promote the evolution of cooperation theoretically and empirically. Besides, current studies show that the coevolution of teaching activity can promote cooperation. Thus, inspired by aforementioned above, we investigate the effect of coevolution of teaching activity on the evolution of cooperation for prisoner's dilemma game with voluntary participation: when the focal player successfully enforces its strategy on the opponent, his teaching ability will get an increase...
2018: PloS One
https://www.readbyqxmd.com/read/29451892/assessing-site-formation-and-assemblage-integrity-through-stone-tool-refitting-at-gruta-da-oliveira-almonda-karst-system-torres-novas-portugal-a-middle-paleolithic-case-study
#20
Marianne Deschamps, João Zilhão
We use stone tool refitting to assess palimpsest formation and stratigraphic integrity in the basal units of the Gruta da Oliveira archeo-stratigraphic sequence, layers 15-27, which TL and U-series dating places in late Marine Isotope Stage (MIS) 5 or early MIS 4. As in most karst contexts, the formation of this succession involved multiple and complex phenomena, including subsidence, bioturbation, carnivore activity and runoff as agents of potential post-depositional disturbance. During phases of stabilization, such as represented by layers 15, 21 and 22, the excavated area was inhabited and refits corroborate that post-depositional displacement is negligible...
2018: PloS One
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