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https://www.readbyqxmd.com/read/29351233/postpartum-women-s-perspectives-of-engaging-with-a-dietitian-and-exercise-physiologist-via-video-consultations-for-weight-management-a-qualitative-evaluation
#1
Lisa Vincze, Megan E Rollo, Melinda J Hutchesson, Robin Callister, Debbe I Thompson, Clare E Collins
Optimising weight status after childbirth is important. Video consultations are an unexplored opportunity to deliver real-time support to postpartum women to improve lifestyle behaviours. This study aims to provide insight into postpartum women's perspectives of engaging with a dietitian and exercise physiologist through video consultations for tailored nutrition and exercise care. A qualitative study using individual telephone interviews (13-36 min) was undertaken. 21 women (body mass index (BMI): 28.1 ± 3...
January 19, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29350692/control-and-optimisation-of-fluid-flow-in-glaucoma-drainage-device-surgery
#2
Kin Sheng Lim
Avoidance of hypotony in the early post-operative phase following glaucoma drainage device surgery is paramount, if serious complications are to be avoided. Current strategies of preventing early hypotony are either a valve mechanism, as those found in Ahmed Glaucoma Valve or flow restrictor as used in Baerveldt or Molteno implants. The Ahmed glaucoma valve has a pre-tensioned valve which opens and closes at the pre-determined level of intra-ocular pressure. Although the opening and closing pressure can be slightly inconsistent, coinciding with the change of material used in the plate construction, the reliability appears to have improved in recent years...
January 19, 2018: Eye
https://www.readbyqxmd.com/read/29350335/tools-for-assessment-of-the-appropriateness-of-prescribing-and-association-with-patient-related-outcomes-a-systematic-review
#3
REVIEW
Nashwa Masnoon, Sepehr Shakib, Lisa Kalisch-Ellett, Gillian E Caughey
BACKGROUND: There are tools and criteria in the literature aimed at distinguishing between appropriate and inappropriate medicines use. However, many have not been externally validated with regard to patient-related outcomes, potentially limiting their use in clinical practice. OBJECTIVES: The aim of the study was to conduct a systematic review to summarise (1) available prescribing appropriateness assessment tools and criteria, and (2) their associations with patient-related outcomes (external validity)...
January 19, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29350232/impact-of-droplets-on-immiscible-liquid-films
#4
Zhizhao Che, Omar K Matar
The impact of droplets on liquid films is a ubiquitous phenomenon not only in nature but also in many industrial applications. Compared to the widely-studied impact of droplets on films of identical fluids, the impact of droplets on immiscible films has received far less attention. In the present work, we show using high-speed imaging that immiscibility has a profound effect on the impact dynamics. The impact of a water droplet on an oil film leads to the formation of a compound crown followed by a central jet, whereas that of an oil droplet on a water film results in rapid spreading on the film surface driven by a large, positive spreading factor...
January 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29349775/the-association-between-borderline-pre-operative-anaemia-in-women-and-outcomes-after-cardiac-surgery-a-cohort-study
#5
G Blaudszun, K E Munting, A Butchart, C Gerrard, A A Klein
Anaemia is common before cardiac surgery and is associated with increased morbidity and mortality. The World Health Organization (WHO) definition of anaemia is lower for women than for men by 10 g.l-1 , potentially putting women at a disadvantage compared with men with regard to pre-operative optimisation. Our hypothesis was that women with borderline anaemia (defined by us as haemoglobin concentration 120-129 g.l-1 ) would have a higher rate of red cell transfusion, morbidity and mortality than non-anaemic women (haemoglobin ≥ 130 g...
January 19, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29348910/determinants-of-colour-constancy-and-the-blue-bias
#6
David Weiss, Christoph Witzel, Karl Gegenfurtner
We investigated several sensory and cognitive determinants of colour constancy across 40 illumination hues. In the first experiment, we measured colour naming for the illumination and for the colour induced by the illumination on the colorimetric grey. Results confirmed that the induced colours are approximately complementary to the colour of the illumination. In the second experiment, we measured colour constancy using achromatic adjustments. Average colour constancy was perfect under the blue daylight illumination and decreased in colour directions away from the blue daylight illumination due to undershooting and a strong blue bias...
November 2017: I-Perception
https://www.readbyqxmd.com/read/29348573/exendin-4-encapsulated-dissolving-microneedle-arrays-for-efficient-treatment-of-type-2-diabetes
#7
Shayan Fakhraei Lahiji, Yoojung Jang, Inyoung Huh, Huisuk Yang, Mingyu Jang, Hyungil Jung
Dissolving microneedles (DMNs) are microscopic needles capable of delivering encapsulated compounds and releasing them into the skin in a minimally invasive manner. Most studies indicate that encapsulating therapeutics in DMNs is an efficacious approach; however, the importance of evaluating the activity of encapsulated compounds, during the fabrication process, has not been examined in detail. Conducting an analysis of thermal, chemical, and physical stress factors, including temperature, pH, and the interaction of the polymer and therapeutics mixture during preparation, is essential for retaining the activity of encapsulated therapeutics during and after fabrication...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29346297/the-dynamic-performance-of-flexural-ultrasonic-transducers
#8
Andrew Feeney, Lei Kang, George Rowlands, Steve Dixon
Flexural ultrasonic transducers are principally used as proximity sensors and for industrial metrology. Their operation relies on a piezoelectric ceramic to generate a flexing of a metallic membrane, which delivers the ultrasound signal. The performance of flexural ultrasonic transducers has been largely limited to excitation through a short voltage burst signal at a designated mechanical resonance frequency. However, a steady-state amplitude response is not generated instantaneously in a flexural ultrasonic transducer from a drive excitation signal, and differences in the drive characteristics between transmitting and receiving transducers can affect the measured response...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29345606/prevalence-of-transmitted-drug-resistance-among-hiv-1-treatment-naive-patients-in-beijing
#9
Y X Song, R L Xin, Z C Li, H W Yu, W H Lun, J Ye, A Liu, A X Li, J W Li, J Z Ye, M Q Hao, H Y Lu, L J Sun
To optimise patients' outcomes and gain insight into transmitted drug resistance (TDR) among human immunodeficiency virus (HIV)-1 treatment-naive patients in Beijing, the prevalence of TDR was assessed. Demographic and clinical data of 1241 treatment-naive patients diagnosed between April 2014 and February 2015 were collected. TDR was defined using the Stanford University HIV drug resistance mutations database. The risk factors were evaluated by multi-logistic regression analysis. Among 932 successfully amplified cases, most were male (96...
January 18, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29345283/regulation-of-programmed-death-ligand-in-the-human-head-and-neck-squamous-cell-carcinoma-microenvironment-is-mediated-through-matrix-metalloproteinase-mediated-proteolytic-cleavage
#10
Mayuko Hira-Miyazawa, Hiroyuki Nakamura, Mariko Hirai, Yutaka Kobayashi, Hiroko Kitahara, George Bou-Gharios, Shuichi Kawashiri
Recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a devastating malignancy with a poor prognosis. According to recent clinical studies, tumour growth can be effectively reduced and survival can be improved by blocking the programmed death receptor-1 (PD-1)/programmed death-ligand 1 (PD‑L1) pathway. PD-L1 expression has been proposed as a potential causative mechanism, as HNSCC is highly immunosuppressive. However, anti-PD-1 treatment is beneficial only for certain patients...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29344088/incidence-and-root-causes-of-delays-in-emergency-orthopaedic-procedures-a-single-centre-experience-of-36-017-consecutive-cases-over-seven-years
#11
Ulla Caesar, Jon Karlsson, Elisabeth Hansson
Background: Emergency surgery is unplanned by definition and patients are scheduled for surgery with minimal preparation. Some patients who have sustained emergency orthopaedic trauma or other conditions must be operated on immediately or within a few hours, while others can wait until the hospital's resources permit and/or the patients' health status has been optimised as needed. This may affect the prioritisation procedures for both emergency and elective surgery and might result in waiting lists, not only for planned procedures but also for emergencies...
2018: Patient Safety in Surgery
https://www.readbyqxmd.com/read/29343890/first-two-bilateral-hand-transplantations-in-india-part-2-technical-details
#12
Mohit Sharma, Subramania Iyer, P Kishore, Jimmy Mathew, Raghuveer Reddy, Janarthanan Ramu, Sundeep Vijayaraghavan, Abhijeet Wakure, S M Mali Chetan, Visakh Varma, Ashish Chaudhari, Swapnil Dhake, Akshay Omkumar, Jerry Paul, Sunil Rajan, Ayyappan Nair, Druvan Shaji
Introduction: This article deals with two patients who underwent bilateral hand transplantation following amputation of both upper limbs at the distal third of the foream. Materials and Methods: The first patient had a history of loss of hands in a train accident , with possiblity of a run over element during the injury. The second patient lost his both hands in a mine blast. The preoperative work up included detailed clinical and psychological evaluation. The donor retrieval was similar in both the cases and the donors were housed in our own instittution...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29343727/predcrp-predicting-and-analysing-the-regulatory-roles-of-crp-from-its-binding-sites-in-escherichia-coli
#13
Ming-Ju Tsai, Jyun-Rong Wang, Chi-Dung Yang, Kuo-Ching Kao, Wen-Lin Huang, Hsi-Yuan Huang, Ching-Ping Tseng, Hsien-Da Huang, Shinn-Ying Ho
Cyclic AMP receptor protein (CRP), a global regulator in Escherichia coli, regulates more than 180 genes via two roles: activation and repression. Few methods are available for predicting the regulatory roles from the binding sites of transcription factors. This work proposes an accurate method PredCRP to derive an optimised model (named PredCRP-model) and a set of four interpretable rules (named PredCRP-ruleset) for predicting and analysing the regulatory roles of CRP from sequences of CRP-binding sites. A dataset consisting of 169 CRP-binding sites with regulatory roles strongly supported by evidence was compiled...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343294/effect-of-glycaemic-control-on-complications-following-cardiac-surgery-literature-review
#14
REVIEW
M Navaratnarajah, R Rea, R Evans, F Gibson, C Antoniades, A Keiralla, M Demosthenous, G Kassimis, G Krasopoulos
INTRODUCTION: No uniform consensus in the UK or Europe exists, for glycaemic management of patients with Diabetes or pre-diabetes undergoing cardiac surgery. OBJECTIVE: [i] Determine the relationship between glycaemic control and cardiac surgical outcomes; [ii] Compare current vs gold standard management of patients with Diabetes or pre-diabetes undergoing cardiac surgery. METHODS: Searches of MEDLINE, NHS Evidence and Web of Science databases were completed...
January 17, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29343288/changes-in-the-secretome-of-tri-dimensional-spheroid-cultured-human-mesenchymal-stem-cells-in-vitro-by-interleukin-1-priming
#15
Elena Redondo-Castro, Catriona J Cunningham, Jonjo Miller, Helena Brown, Stuart M Allan, Emmanuel Pinteaux
BACKGROUND: Mesenchymal stem cells (MSCs) are one of the most promising candidates for the treatment of major neurological disorders. Desirable therapeutic properties of MSCs include reparative and regenerative potential but, despite their proven safety, the efficacy of MSCs remains controversial. Therefore, it is essential to optimise culture protocols to enhance the therapeutic potential of the MSC secretome. Here we aimed to: assess the increase in secretion of cytokines that may induce repair, regeneration, or immunomodulation when cultured in three dimensions; study the effect of interleukin (IL)-1 priming on two- (2D) and three-dimensional (3D) cultures of MSC; and evaluate the potential use of the modified secretome using microglial-MSC co-cultures...
January 17, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29342291/portuguese-study-of-mean-glandular-dose-in-mammography-and-comparison-with-european-references
#16
Cláudia Sá Dos Reis, Mário João Fartaria, João H Garcia Alves, Ana Pascoal
To characterise the mean glandular dose (MGD) in a sample of healthcare providers for digital mammography in Portugal. To compare the achieved values with European references. The MGD was measured on a poly-methyl-methacrylate phantom (45 mm) for each system using dosimeters. In addition, MGD was estimated using exposure settings collected from mammography exams in clinical context. Data were collected from 25 computed-radiography systems (CR) and 13 integrated digital (DR). For both measurements (phantom and clinical exposures), the average MGD for CR was higher compared to the DR...
January 12, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29342192/white-matter-tract-specific-quantitative-analysis-in-multiple-sclerosis-comparison-of-optic-radiation-reconstruction-techniques
#17
Chenyu Wang, Alexander Klistorner, Linda Ly, Michael H Barnett
The posterior visual pathway is commonly affected by multiple sclerosis (MS) pathology that results in measurable clinical and electrophysiological impairment. Due to its highly structured retinotopic mapping, the visual pathway represents an ideal substrate for investigating patho-mechanisms in MS. Therefore, a reliable and robust imaging segmentation method for in-vivo delineation of the optic radiations (OR) is needed. However, diffusion-based tractography approaches, which are typically used for OR segmentation are confounded by the presence of focal white matter lesions...
2018: PloS One
https://www.readbyqxmd.com/read/29342152/do-nursery-habitats-provide-shelter-from-flow-for-juvenile-fish
#18
Darren M Parsons, Iain MacDonald, Dane Buckthought, Crispin Middleton
Juvenile fish nurseries are an essential life stage requirement for the maintenance of many fish populations. With many inshore habitats globally in decline, optimising habitat management by increasing our understanding of the relationship between juvenile fish and nursery habitats may be a prudent approach. Previous research on post-settlement snapper (Chrysophrys auratus) has suggested that structure may provide a water flow refuge, allowing snapper to access high water flow sites that will also have a high flux of their pelagic prey...
2018: PloS One
https://www.readbyqxmd.com/read/29341138/model-fitting-for-small-skin-permeability-data-sets-hyperparameter-optimisation-in-gaussian-process-regression
#19
Parivash Ashrafi, Yi Sun, Neil Davey, Roderick G Adams, Simon C Wilkinson, Gary Patrick Moss
OBJECTIVES: The aim of this study was to investigate how to improve predictions from Gaussian Process models by optimising the model hyperparameters. METHODS: Optimisation methods, including Grid Search, Conjugate Gradient, Random Search, Evolutionary Algorithm and Hyper-prior, were evaluated and applied to previously published data. Data sets were also altered in a structured manner to reduce their size, which retained the range, or 'chemical space' of the key descriptors to assess the effect of the data range on model quality...
January 17, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29340820/the-development-and-validation-of-a-scoring-tool-to-predict-the-operative-duration-of-elective-laparoscopic-cholecystectomy
#20
Reshma Bharamgoudar, Aniket Sonsale, James Hodson, Ewen Griffiths
BACKGROUND: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. METHODS: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration...
January 16, 2018: Surgical Endoscopy
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