keyword
https://read.qxmd.com/read/37785251/a-seer-database-cohort-of-547-patients-with-non-squamous-cell-carcinoma-of-the-penis-clinical-characteristics-and-outcomes
#21
JOURNAL ARTICLE
L W Ashley, K F Sutton, G Edwards, A Burke, M S Peach, A W Ju, A Bhatt
PURPOSE/OBJECTIVE(S): Little research has investigated the prevalence and distribution of the diverse pathologies of non-squamous cell carcinoma (non-SCC) of the penis. Although rare in clinical practice, these cancers have become a focus of greater importance among patients, clinicians, and researchers, particularly in developing countries. The principal objective of this study was to analyze the major types of penile non-squamous cell carcinoma, elucidate common treatment pathways, and highlight outcomes including 5-year survival...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37632880/hepatic-metastasis-revealing-a-melanoma-of-the-penis-case-report
#22
Meriem Boui, Nabil Hammoune, Badr Slioui, Zakaria Zouaki, Mehdi Atmane, Abdelilah Mouhsine, Mohamed Amine Haouane, Mohamed Amine Azami, Mohamed Kaakoua, Ismail Assadi, Mohammed Boui, Ahmed Bouhamidi
Melanoma of the penis is a rare tumor with a poor prognosis. We report the case of a 73-year-old patient with no significant medical history, admitted for deterioration of the general condition and bilateral inguinal lymph nodes. An abdominal ultrasound and thoraco-abdomino-pelvic CT (computed tomography) scan revealed metastatic liver nodules, the tumoral nature of which was confirmed by an anatomopathological examination. Further clinical examination revealed papular and ulcerated lesions of the penis located at the urethral meatus and glans penis...
September 27, 2022: JMIR dermatology
https://read.qxmd.com/read/37611396/primary-malignant-melanoma-of-the-male-urethra-case-report-and-review-of-literature
#23
Quang Nguyen, Huu Thao Nguyen, Xuan Truong Bui, Van Quang Bui, Tien Dung Nguyen
INTRODUCTION: We report a rare case of primary malignant melanoma with inguinal lymph node metastasis in the male urethra. CASE PRESENTATION: A 57-year-old male patient presented with a small tumor on the ventral surface of the penis, which was discovered 5 months ago and did not cause pain or discomfort. In the past month, the patient has developed symptoms of urinary incontinence. MRI and PET/CT scans revealed a primary tumor in the penile urethra, but no metastases were found...
September 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37538829/therapeutic-efficacy-of-211-at-radiolabeled-2-6-diisopropylphenyl-azide-in-mouse-models-of-human-lung-cancer
#24
JOURNAL ARTICLE
Yudai Ode, Ambara R Pradipta, Peni Ahmadi, Akihiro Ishiwata, Akiko Nakamura, Yasuko Egawa, Yuriko Kusakari, Kyohei Muguruma, Yang Wang, Xiaojie Yin, Nozomi Sato, Hiromitsu Haba, Katsunori Tanaka
Targeted α-particle therapy (TAT) is an attractive alternative to conventional therapy for cancer treatment. Among the available radionuclides considered for TAT, astatine-211 (211 At) attached to a cancer-targeting molecule appears very promising. Previously, we demonstrated that aryl azide derivatives could react selectively with the endogenous acrolein generated by cancer cells to give a diazo compound, which subsequently forms a covalent bond with the organelle of cancer cells in vivo . Herein, we synthesized 211 At-radiolabeled 2,6-diisopropylphenyl azide (ADIPA), an α-emitting molecule that can selectively target the acrolein of cancer cells, and investigated its antitumor effect...
August 2, 2023: Chemical Science
https://read.qxmd.com/read/37534583/yolk-sac-tumour-arising-in-the-glans-penis-an-achondroplasic-child-a-case-report-with-summary-of-prior-published-cases
#25
JOURNAL ARTICLE
Sanjana Karan, Raktim Mukherjee, Pritam Singha Roy, Md Mohin, Wasim Firdous, Uttara Chatterjee
BACKGROUND: Yolk sac tumors (YST) are commonly encountered gonadal germ cell tumors in children, especially in the prepubertal age group. In addition to gonadal primary, it can occur in multiple extragonadal sites, of which sacrococcygeal, retroperitoneum, gastric and mediastinum are the commonest. There are 4 previous reports of primary penile YST. CASE REPORT: We describe a primary penile yolk sac tumor in a child with achondroplasia. CONCLUSION: Yolk sac tumor can occur in the penis during the prepubertal period...
August 3, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37533000/large-solitary-fibrous-tumor-sft-of-the-penis-a-case-report-and-review-of-literature
#26
JOURNAL ARTICLE
Deep Kumar Jain, Himanshu Pandey, Sashank Saini, Sashikant Patne
BACKGROUND: Solitary fibrous tumors (SFTs) are very rare spindle cell neoplasms of mesenchymal origin with largely benign course of disease. Genital SFT's can be managed providing excellent functional and psychological outcomes by timely intervention. CASE PRESENTATION: We report the largest and possibly the second only reported case of penile SFT in a 34 year male presenting with a gradually increasing perineal mass with clinically normal appearing phallus...
August 2, 2023: BMC Urology
https://read.qxmd.com/read/37521276/penoscrotal-low-grade-fibromyxoid-sarcoma-a-case-report
#27
Abbas Basiri, Parham Montazeri, Mehdi Dadpour
Low-grade fibromyxoid sarcoma (LGFMS) is a subtype of sarcoma that commonly arises from the deep soft tissue. We present a case of LGFMS originated from the penoscrotal junction area, which highlights the unusual site of LGFMS presentation.The patient presented with a mass in the left base of the penis, which was resected and the pathology report was compatible with LGFMS. However, local recurrence near the primary tumor site was detected 3 months postoperatively, and re-excision confirmed the same diagnosis...
September 2023: Urology Case Reports
https://read.qxmd.com/read/37506474/regional-differences-in-penile-cancer-patient-characteristics-and-treatment-rates-across-the-united-states
#28
JOURNAL ARTICLE
Lukas Scheipner, Cristina Cano Garcia, Francesco Barletta, Reha-Baris Incesu, Simone Morra, Andrea Baudo, Anis Assad, Zhe Tian, Fred Saad, Shahrokh F Shariat, Felix K H Chun, Alberto Briganti, Derya Tilki, Nicola Longo, Luca Carmignani, Marianne Leitsmann, Sascha Ahyai, Pierre I Karakiewicz
INTRODUCTION: We tested for regional-specific differences in patient, tumor and treatment characteristics as well as cancer-specific mortality (CSM) of squamous cell carcinoma of the penis (SCCP) patients, across the Surveillance, Epidemiology, and End Results (SEER) registries. METHODS: The SEER database (2000-2018) was used to tabulate patient (age at diagnosis, race/ethnicity), tumor (stage, grade, N-stage) and treatment characteristics (proportions of primary tumor surgery, local lymph node surgery, systemic therapy), according to 12 SEER registries...
July 26, 2023: Cancer Epidemiology
https://read.qxmd.com/read/37491831/male-infertility-and-urological-tumors-pathogenesis-and-therapeutical-implications
#29
REVIEW
G Gulino, A Distante, A Akhundov, P F Bassi
Most genitourinary tract cancers have a negative impact on male fertility. Although testicular cancers have the worst impact, other tumors such as prostate, bladder, and penis are diagnosed early and treated in relatively younger patients in which couple fertility can be an important concern. The purpose of this review is to highlight both the pathogenetic mechanisms of damage to male fertility in the context of the main urological cancers and the methods of preserving male fertility in an oncological setting, in light of the most recent scientific evidence...
July 25, 2023: Urologia
https://read.qxmd.com/read/37487169/atezolizumab-with-or-without-radiotherapy-for-advanced-squamous-cell-carcinoma-of-the-penis-the-pericles-study-a-phase-ii-trial
#30
JOURNAL ARTICLE
Hielke M de Vries, Tynisha S Rafael, Alberto Gil-Jimenez, Jeantine M de Feijter, Elise Bekers, Elsbeth van der Laan, Marta Lopez-Yurda, Erik Hooijberg, Annegien Broeks, Dennis Peters, Iris M Seignette, Floris J Pos, Simon Horenblas, Bas W G van Rhijn, Ekaterina S Jordanova, Oscar R Brouwer, Eva Schaake, Michiel S van der Heijden
PURPOSE: Patients with advanced penile squamous cell carcinoma have a poor prognosis (21% 2-year overall survival [OS] from diagnosis). We assessed the activity of atezolizumab (anti-PD-L1) in patients with advanced penile cancer, with or without radiotherapy (RT). PATIENTS AND METHODS: A single-center, nonrandomized phase II study with two treatment arms was conducted in 32 patients with histologically confirmed advanced penile cancer. All patients received atezolizumab (1,200 mg) once every 3 weeks...
November 1, 2023: Journal of Clinical Oncology
https://read.qxmd.com/read/37471245/malignant-neoplasms-of-the-penis-with-radiologic-and-pathologic-correlation
#31
JOURNAL ARTICLE
Meghan G Lubner, Jamie Marko, Rong Hu, Akira Kawashima, Theodora A Potretzke, Aletta Ann Frazier, Ryan Whiting, Aaron M Udager
Penile malignancy is the third most common male-specific genitourinary malignancy, with squamous cell carcinoma representing the most common histologic type. Squamous cell carcinoma is an epithelial malignancy, frequently developing from the mucosal surfaces of the foreskin, glans, and coronal sulcus and manifesting as a distal infiltrative or ulcerated mass. This typically occurs in men from the 6th to 8th decades of life, and risk factors include human papillomavirus, phimosis, presence of foreskin and poor hygiene, chronic inflammatory conditions such as lichen sclerosus, trauma, and smoking...
August 2023: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/37466795/the-role-of-surgery-in-the-treatment-of-neuroblastoma-metastases-at-rare-sites
#32
JOURNAL ARTICLE
Simon Scherer, Benjamin F B Mayer, Markus Dietzel, Michael Esser, Steven W Warmann, Peter Lang, Martin U Schuhmann, Andreas Schmidt, Jörg Fuchs
PURPOSE: Treatment of neuroblastoma metastases usually consists of chemotherapy and irradiation. However, in selected cases, surgical treatment is also indicated. In this study, we present three cases of patients with neuroblastoma metastases at rare sites that underwent surgery. MATERIALS AND METHODS: We retrospectively analyzed data of patients who underwent surgery for neuroblastoma at our department of Pediatric Surgery and Pediatric Urology at the University Children's Hospital in Tuebingen and selected those patients who had surgery explicitly for a metastasis...
July 19, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37419483/adverse-drug-events-lichen-planus-of-the-penis-after-intake-of-nebivolol-first-reported-case-in-the-world-literature
#33
JOURNAL ARTICLE
G Tchernev, V Broshtilova
The pathogenesis of lichen planus and lichenoid-type reactions remains shrouded in mystery to this day, precisely because of the inability to perform acute/specific tests for reproduction of a particular type of reaction (in this case lichenoid) in order to prove a causal relationship. Nevertheless, the concept of molecular mimicry/antigen mimicry as a possible important pathogenetic inducer for lichen planus and lichenoid-type reactions, is increasingly becoming a topic of discussion and remains more than relevant at present...
May 2023: Georgian Medical News
https://read.qxmd.com/read/37324166/programmed-death%C3%A2-ligand-1-expression-in-tumor-cells-and-tumor%C3%A2-infiltrating-lymphocytes-are-associated-with-depth-of-tumor-invasion-in-penile-cancer
#34
JOURNAL ARTICLE
Sakkarn Sangkhamanon, Natcha Kotano, Wichien Sirithanaphol, Ukrit Rompsaithong, Pakorn Kiatsopit, Aumkhae Sookprasert, Kosin Wirasorn, Prin Twinprai, Piyakarn Watcharenwong, Jarin Chindaprasirt
The present study aimed to demonstrate the proportion of the programmed death-ligand 1 (PD-L1) expression in penile cancer patients and the association with clinicopathological parameters. Formalin-fixed paraffin-embedded specimens were obtained from 43 patients with primary penile squamous cell carcinoma treated at Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, between 2008 and 2018. PD-L1 expression was evaluated by the immunohistochemistry using an SP263 monoclonal antibody. PD-L1 positivity was defined as >25% tumor cell staining or >25% tumor-associated immune cell staining...
July 2023: Biomedical Reports
https://read.qxmd.com/read/37251007/symptom-palliation-with-quad-shot-radiation-therapy-to-penile-metastasis-derived-from-descending-colon-cancer-a-case-report
#35
JOURNAL ARTICLE
Akira Yamamoto, Hideharu Ieki, Mai Shimamura, Masahiro Tsujiura, Takeshi Yokoe, Naoko Sanuki, Eiki Ojima, Keiichi Uchida, Yasuhiko Mohri
A 54-year-old man was diagnosed with descending colon cancer with metastases in the liver, para-aortic lymph nodes, and penis, and chemotherapy was introduced after construction of a colostomy. The patient reported only mild penile pain at the time of diagnosis; however, the pain gradually worsened and interfered with his daily life. Opioids did not provide sufficient analgesia, and the patient developed dysuria and priapism. Through construction of a cystostomy, palliative radiotherapy with QUAD Shot regimen (14 Gy in 4 fractions twice-daily on 2 days repeated every 4 weeks) to the penile metastasis was started for pain relief and tumor shrinkage...
July 2023: International cancer conference journal
https://read.qxmd.com/read/37250961/malignant-solitary-fibrous-tumor-of-the-penis-a-case-report-of-rare-malignancy
#36
Aze Andrea Putra, Ikhlas Arief Bramono, Edward Usfie Harahap, Rachmat Budi Santoso, Evlina Suzanna, Fakhri Rahman
Malignant Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that consists of spindle cell components. The occurrence of SFT in the genitourinary tract is extremely rare. So, there is no clear algorithm for the management of this case. We report A 33-year-old male who complained of recurrent penile swelling in the last 7 months after underwent surgery 3 months earlier. The tumor re-enlarged from the surgical wound's previous sutures. Total penectomy was performed followed by bilateral inguinal lymphadenectomy...
July 2023: Urology Case Reports
https://read.qxmd.com/read/37245208/-penile-epithelioid-hemangioma
#37
JOURNAL ARTICLE
Mihály Murányi, Chie Yi-Che Chang, Mátyás Benyó, Tibor Flaskó
Epithelioid hemangioma is a benign vascular tumor. Complete surgical excision is curative, there is no tendency to recurrence or metastasize. Its penile occurrence is extremely rare, only 33 cases have been reported in English literature. A patient with epithelioid hemangioma of the deep dorsal vein of the penis is reported. To our knowledge, this is the first report of penile epithelioid hemangioma in Hungarian literature. The 64-year-old patient presented to our department with painful erection caused by a palpable penile mass...
May 28, 2023: Orvosi Hetilap
https://read.qxmd.com/read/37232803/clinical-profile-and-predictors-of-survival-in-carcinoma-penis-patients
#38
JOURNAL ARTICLE
Vikas Garg, Mukurdipi Ray, K P Haresh, Ranjit Kumar Sahoo, Atul Sharma, Seema Kaushal, Atul Batra
BACKGROUND: Carcinoma penis is a rare neoplasm, and the literature is scarce on long-term survival and its predictors. The aim of the study was to determine the clinical profile and management patterns, identify predictors of survival, and the impact of education and rural/urban dwelling on survival. METHODS: Patients with a histological diagnosis of carcinoma penis from January 2015 to December 2019 were included in the study. Demographics, clinical profile, education status, primary residence address, and outcomes were obtained from the case records...
April 28, 2023: Current Oncology
https://read.qxmd.com/read/37201076/surgery-radiotherapy-chemotherapy-targeted-therapy-and-immunotherapy-of-rectal-adenocarcinoma-with-penile-metastasis-a-case-report
#39
Zhanyu Wang, Jiahui Shan, Xinjie Zhou, Jianwei Wang, Guangyang Yu, Wei Dong, Fei Huai, Qi Sun, Guoliang Lu, Zhenzhen Ma, Hechen Liu
BACKGROUND: Despite the rich proximity and vascularization to the pelvic organs, metastatic lesions to the penis are incredibly uncommon. Most primary tumors are genitourinary cancers, and rectal origins are rare. Only 56 cases of metastatic penile tumors have been reported since 1870. Several palliative or curative methods, such as chemotherapy, total penectomy, and radiotherapy, have been applied to treat this condition in previous cases; however, the patient prognosis is poor. Immunotherapy is a beneficial treatment approach for multiple cancers, and recent investigations have shown that it may be beneficial for patients with advanced penile cancer...
April 29, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/37144080/myopericytoma-in-the-corpus-cavernosum-of-the-penis-a-case-report-of-a-rare-disease
#40
Hiroki Oshiro, Yousuke Shimizu, Ryota Nakayasu, Noriaki Utsunomiya, Satsuki Asai, Misa Ishihara, Kimio Hashimoto, Hiroki Katsushima, Sojun Kanamaru
INTRODUCTION: Myopericytomas usually occur in the extremities of older individuals; however, they also rarely occur in the penis. We report a case of myopericytoma in the corpus cavernosum of the penis and review the relevant literature. CASE PRESENTATION: A 76-year-old man presented with a slow-growing painless nodule on the left side of the penis. On physical examination, a non-tender, 7-mm mass was palpable. This tumor showed inhomogeneous low signal intensity on T2-weighted magnetic resonance imaging...
May 2023: IJU case reports
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