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https://www.readbyqxmd.com/read/28417078/local-excision-for-the-treatment-of-penile-verrucous-carcinoma
#1
Dong In Jo, Sang Kyu Choi, Soon Heum Kim, Cheol Keun Kim, Hong Chung, Hong Sup Kim
Penile verrucous carcinoma is known for its favorable biologic behavior and lack of metastatic potential. For preservation of function, treatment has been focused on partial penectomy. Despite partial penectomy for preservation of minimal functional and aesthetic aspects, patients have experienced psychosexual problems. A 73-year-old man had a cauliflower-like verrucous carcinoma on the penile glans and coronary sulcus diagnosed by using excisional biopsy. He underwent degloving excision to save the penile shaft and glans penis...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28382926/aldosterone-induces-inflammatory-cytokines-in-penile-corpus-cavernosum-by-activating-the-nf-%C3%AE%C2%BAb-pathway
#2
Fei Wu, Zu-Quan Xiong, Shan-Hua Mao, Ji-Meng Hu, Jian-Qing Wang, Hao-Wen Jiang, Qiang Ding
Emerging evidence indicates that aldosterone and mineralocorticoid receptors (MRs) are associated with the pathogenesis of erectile dysfunction. However, the molecular mechanisms remain largely unknown. In this study, freshly isolated penile corpus cavernosum tissue from rats was treated with aldosterone, with or without MRs inhibitors. Nuclear factor (NF)-kappa B (NF-κB) activity was evaluated by real-time quantitative PCR, luciferase assay, and immunoblot. The results demonstrated that mRNA levels of the NF-κB target genes, including inhibitor of NF-κB alpha (IκB-α), NF-κB1, tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6), were higher after aldosterone treatment...
April 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28363474/disparity-between-pre-existing-management-of-penile-cancer-and-nccn-guidelines
#3
Rebecca A Campbell, Emily A Slopnick, Elizabeth K Ferry, Hui Zhu, Simon P Kim, Robert Abouassaly
OBJECTIVE: To determine the locoregional management of penile cancer before the introduction of NCCN guidelines and how much shift in practice patterns is required to meet the guidelines. METHODS: The National Cancer Data Base was queried to identify 6,396 patients with squamous cell carcinoma of the penis diagnosed between 2004 and 2013. The cohort was divided into management groups based on the NCCN guidelines: cTa and cTis (cTa/is), pT1 low grade (T1LG), pT1 high grade (T1HG), and pT2 or greater (T234)...
March 28, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28345835/evolution-of-the-histo-epidemiological-profile-of-urological-cancers-in-togo
#4
Tchin Darré, Koué Folligan, Tchilabalo Matchonna Kpatcha, Kokou Kanassoua, Edoe Sewa, Sassil Daré, Kodjo Tengue, Koffi Amégbor, Gado Napo Koura
Background: Urological cancers are an important public health issue and pose problems with diagnosis and adequate management in developing countries. Our aim was to determine and report epidemiological and histological features of urological cancers in Togo. Materials and methods: A retrospective descriptive study was conducted of cases of urological cancers observed in the laboratory of pathological anatomy of the CHU Tokoin over the last 4 years (2012-2016). The parameters studied were frequency, age, sex, sites of development and histological type...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28291123/medullary-carcinoma-of-the-penis-a-distinctive-hpv-related-neoplasm-a-report-of-12-cases
#5
Sofía Cañete-Portillo, Omar Clavero, Diego F Sanchez, Arturo Silvero, Francisco Abed, Ingrid M Rodriguez, Gustavo Ayala, Laia Alemany, Nubia Munoz, Silvia de Sanjose, Wim Quint, Francesc X Bosch, Antonio L Cubilla
A third to half of penile invasive squamous cell carcinomas are human papillomavirus (HPV) related. Warty (condylomatous), warty-basaloid, and basaloid carcinomas are the most common subtypes associated with HPV. Less frequent are clear cell and lymphoepithelioma-like carcinomas. Here we report a novel penile tumor associated with HPV. Twelve cases were selected from 1010 penile carcinomas, part of an international HPV detection study conducted at the Institut Català d'Oncologia, Barcelona, Spain. Immunostaining with p16 was performed on all cases, and HPV-mRNA detection was also performed...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28288040/incidentally-detected-penile-metastases-in-a-patient-of-carcinoma-urinary-bladder-on-follow-up-fdg-pet-ct
#6
Girish Kumar Parida, Sarthak Tripathy, Shambo Guha Roy, Abhinav Singhal, Chandanjyoti Das, Shamim Ahmed Shamim
Penis is an extremely uncommon site for metastases to occur and is often associated with very grave prognosis. Most of the secondary tumors originating in the penis have primaries from prostate, urinary bladder, and gastrointestinal tract. We hereby report a 65-year-old man, known case of carcinoma urinary bladder, who came for FDG PET/CT for metastatic workup. PET/CT study revealed FDG-avid mass lesion in the root and shaft of the penis, making it suggestive of metastases, which was confirmed later by MRI correlation...
May 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28209454/treatment-of-carcinoma-in-situ-of-the-glans-penis-with-topical-imiquimod-followed-by-carbon-dioxide-laser-excision
#7
Tullio Torelli, Mario A Catanzaro, Nicola Nicolai, Patrizia Giannatempo, Andrea Necchi, Daniele Raggi, Biagio Paolini, Maurizio Colecchia, Luigi Piva, Davide Biasoni, Silvia Stagni, Antonio Tesone, Roberto Salvioni
BACKGROUND: Different approaches have been described in published studies for carcinoma in situ (CIS) of the glans penis (erythroplasia of Queyrat), including topical chemotherapy or immunotherapy and laser or surgical excision. We evaluated the efficacy of topical imiquimod (IQ) followed by carbon dioxide laser ablation of the lesion. PATIENTS AND METHODS: From 2010 to 2015, 10 patients affected by CIS of the glans were treated by IQ, followed by carbon dioxide laser ablation...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28071635/prognostic-factors-and-5-year-survival-of-patients-with-carcinoma-penis-tertiary-health-center-study
#8
A A Shah, H A Shah, G N Panjwani, B B Pandey, N Shah
CONTEXT: To identify prognostic factors in carcinoma penis with its impact on survival. AIMS: To find out the relation of various prognostic factors of carcinoma penis with the various outcomes. SETTINGS AND DESIGN: Retrospective cohort study. SUBJECTS AND METHODS: Each patient diagnosed as having carcinoma of penis by incision biopsy and operated from January 2004 to May 2009 at the institute was included in the study (n = 117)...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27998313/embryonal-rhabdomyosarcoma-of-the-perineum-in-an-adult-a-case-report
#9
Sidy Ka, Freddy Gnangnon, Mamadou Moustapha Dieng, Doudou Diouf, Jaafar Thiam, Pape Macoumba Gaye, Ahmadou Dem
BACKGROUND: We report the case of an adult patient with embryonal rhabdomyosarcoma of the perineum admitted to our practice at Joliot Curie Institute in Dakar. It is a rare tumor at this age and has a bad prognosis at this localization. CASE PRESENTATION: We describe the case of a 22-year-old African man admitted for a perineal mass that had evolved over 6 months. He complained of tenesmus, obstinate constipation, and dysuria. A clinical examination revealed perineal swelling spread over his anus, scrotum, penis, testicles, and inguinal lymph nodes...
December 20, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27995080/electrochemotherapy-increases-local-control-after-incomplete-excision-of-a-recurring-penile-fibrosarcoma-in-a-stallion
#10
E P Spugnini, C Bolaffio, L Scacco, A Baldi
An eleven-year-old stallion was referred for adjuvant treatment of an incompletely excised, recurring penile fibrosarcoma. The horse was bright, alert and responsive with a 15 x 12 cm ulcerated lesion on the ventral side of the penis. The lesion was the tumor bed of an incompletely excised fibrosarcoma. After complete staging procedures, the owner elected to treat the horse with electrochemotherapy (ECT) using cisplatin as chemotherapy agent. Two sessions of ECT were performed at two-week intervals using local cisplatin followed by trains of biphasic electric pulses applied using different electrodes until complete coverage of the area was achieved...
2016: Open veterinary journal
https://www.readbyqxmd.com/read/27940757/atypical-leydig-cell-tumor-in-children-report-of-2-cases
#11
Chiara Mameli, Giorgio Selvaggio, Chiara Cerini, Gaetano Bulfamante, Cristina Madia, Giovanna Riccipetitoni, Gian Vincenzo Zuccotti
Leydig cell tumors (LCTs) are rare cord-stromal tumors that may occur in testis or ovaries and may produce androgens or estrogens. The majority has been found in men between the ages of 20 and 60 years. Adults with androgen-secreting LCTs are usually asymptomatic; feminizing syndromes may result from the production of estradiol or the peripheral aromatization of testosterone. In children, LCTs usually present between 5 and 10 years of age with isosexual precocious pseudopuberty or gynecomastia. We report 2 cases of LCT in prepubertal boys presenting with advanced unilateral pubarche and testicular volume asymmetry...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27867327/unusual-glomus-tumor-of-the-penis
#12
REVIEW
Gautam Dagur, Kelly Warren, Yimei Miao, Navjot Singh, Yiji Suh, Sardar A Khan
INTRODUCTION: Glomus tumors are benign neoplasms commonly found in subungual regions of the extremities and rarely located in the penis. Misdiagnosis of glomus tumors is common; therefore, symptoms and clinical presentations should be reviewed. OBJECTIVE: The primary objective of this review article is to emphasize the pathogenesis, pathology, clinical presentation, symptoms, diagnosis, and treatment methods of glomus tumors in order to better identify and manage the condition...
October 2016: Current Urology
https://www.readbyqxmd.com/read/27865145/rectal-gastrointestinal-stromal-tumor-with-metastasis-to-the-penis-case-report-and-review-of-literature
#13
Jacob Carlson, Wilson Alobuia, Jason Mizell
We report the case of a 51-year-old gentleman with previously diagnosed gastrointestinal stromal tumor (GIST) of the rectum with metastasis to the penis. The patient underwent abdominoperineal resection of the primary tumor with negative margins and completed a three-year course of imatinib mesylate (Gleevec). Forty months after resection of his rectal tumor, the patient presented to his urologist with worsening testicular pain, mild lower urinary tract obstructive symptoms, and nocturia. A pelvic MRI revealed the presence of an ill-defined mass in the right perineum extending from the base of the penis to the penoscrotal junction...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27864120/epidermal-growth-factor-receptor-as-an-adverse-survival-predictor-in-squamous-cell-carcinoma-of-the-penis
#14
Alice Muglia Thomaz da Silva Amancio, Isabela Werneck da Cunha, José Ivanildo Neves, Josiane da Silva Quetz, Dirce Maria Carraro, Rafael Malagoli Rocha, Stenio Cássio Zequi, Antonio Leopoldo Cubilla, Francisco Paulo da Fonseca, Ademar Lopes, Maria do Perpétuo Socorro Saldanha da Cunha, Marcos Venício Alves Lima, José Vassallo, Gustavo Cardoso Guimarães, Fernando Augusto Soares
Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted therapy in PC patients, although there is no test that provides accurate patient selection. The aim of the present study was to evaluate the prognostic value of EGFR gene and protein status in tumor samples from patients with primary penile squamous cell carcinoma (SCC)...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27784859/myxoma-of-the-penis-in-an-african-pygmy-hedgehog-atelerix-albiventris
#15
Yoshinori Takami, Namie Yasuda, Yumi Une
A penile tumor (4 × 2.5 × 1 cm) was surgically removed from an African pygmy hedgehog (Atelerix albiventris) aged 3 years and 5 months. The tumor was continuous with the dorsal fascia of the penile head. Histopathologically, tumor cells were pleomorphic (oval-, short spindle- and star-shaped cells) with low cell density. Abundant edematous stroma was weakly positive for Alcian blue staining and positive for colloidal iron reaction. Tumor cells displayed no cellular atypia or karyokinesis. Tumor cell cytoplasm was positive for vimentin antibody, while cytoplasm and nuclei were positive for S-100 protein antibody...
January 20, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27717430/contemporary-role-of-radiotherapy-in-the-management-of-primary-penile-tumors-and-metastatic-disease
#16
REVIEW
Juanita Crook
Squamous cell cancer of the penis is a radiocurable malignancy all too often managed solely by partial or total penectomy. Effective management of the primary tumor while preserving penile morphology and function is a priority. External radiotherapy and brachytherapy have a role to play in the definitive management of the primary tumor. Surgical nodal staging remains a cornerstone of management because it is the strongest predictor of survival, and inguinal status determines pelvic management. Postoperative radiotherapy of the regional nodes for high-risk pathology is indicated...
November 2016: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27696488/primary-cutaneous-adenosquamous-carcinoma-of-the-penis-the-first-characterization-of-hpv-status-in-this-rare-and-diagnostically-challenging-entity-with-review-of-glandular-carcinomas-of-the-penis
#17
P S Rush, J M Shiau, B P Hibler, B J Longley, T M Downs, D D Bennett
Glandular and pseudoglandular tumors of the penile skin are extremely uncommon and can present diagnostic challenges. Primary adenosquamous carcinoma of the penis is an extremely rare tumor, composed of distinct areas of malignant squamous and glandular cells, making it a diagnostically challenging entity. The World Health Organization (WHO) recognizes several subtypes of squamous cell carcinoma (SCC), each with its own distinctive pathologic appearance, clinical associations and prognosis. Among these variants is the exceedingly uncommon adenosquamous carcinoma (ASC), representing 1%-2% of all SCC of the penis...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27689055/three-directional-reconstruction-of-a-massive-perineal-defect-after-wide-local-excision-of-extramammary-paget-s-disease
#18
Seung Woo Cho, Hak Chang, Sung Tack Kwon
Extramammary Paget's disease (EMPD) is a rare, slow-growing intraepithelial malignancy that mainly involves the genital region, including the vulva, penis, scrotum, perianal, and periurethral areas. Although several treatment options exist, wide local excision with a safe margin is considered the treatment of choice. After resection of the lesion, it is often challenging to reconstruct the defect because defects in the perineal region require adequate volume for protection and are susceptible to infections, which is a particularly significant risk for large defects...
September 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27594553/pathologic-evaluation-and-reporting-of-carcinoma-of-the-penis
#19
REVIEW
Andreas Erbersdobler
Carcinoma of the penis is a rare tumor in the United States and in western European countries. Clinical management has become more complex in recent years, because organ-preserving strategies are being favored. Furthermore, our understanding of the pathogenesis of this malignancy has grown considerably. As a result of these developments, the demands on the pathology reports of surgical specimens from the penis have increased. There are also some peculiarities with the current World Health Organization and TNM classification systems of penile cancer as compared with other tumor entities...
August 10, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27557611/anti-inflammatory-and-anti-fibrotic-effects-of-annexin1-on-erectile-function-after-cavernous-nerve-injury-in-rats
#20
F N Facio, M F Facio, L F Spessoto, D Pessutti, L O Reis, S G Campos, S Taboga
The aim of this study was to investigate the effect of the anti-inflammatory and anti-fibrotic actions of ANX1 on erectile function (EF). Forty-eight male Wistar rats were randomly distributed into four equal groups: one group (sham operation-control) and three groups (bilateral cavernous nerve (CN) crush injury). Crush injury groups were treated prior to injury with an intravascular injection of either ANX1 (50 or 100 μg kg(-1)) or vehicle. EF was assessed by CN electrical stimulation at 2 and 7 days after CN injury with histomorphometric and immunohistochemical analysis...
November 2016: International Journal of Impotence Research
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