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https://www.readbyqxmd.com/read/28704194/sarcomatoid-squamous-cell-carcinoma-of-the-penis-a-report-of-two-cases
#1
Svitlana Y Bachurska, Petar A Antonov, Dmitriy G Staykov, Ivan Y Dechev
BACKGROUND: Sarcomatoid (spindle cell) squamous cell carcinoma is a rare, highgrade, aggressive tumor consisting of the squamous cell carcinoma admixed with the malignant spindle cell (sarcomatoid) elements. These tumors are relatively uncommon in the genitourinary system and particularly in the penis. MATERIALS AND METHODS: Two sarcomatoid squamous cell carcinomas of the penis were diagnosed in our hospital between 2012 and 2015. Clinical histories, pathology reports, hematoxylin and eosin-stained and immunohistochemical slides were reviewed...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28689224/mixed-papillary-sarcomatoid-carcinoma-of-the-penis-report-of-an-aggressive-subtype
#2
Graziele Bovolim, Walter Henriques da Costa, Gustavo Cardoso Guimaraes, Fernando Augusto Soares, Isabela Werneck da Cunha
Several different histological subtypes of penile carcinoma had been described in the last decades, many with different biological behavior and prognosis. The association of two histological subtypes (mixed tumors) can be observed in one third of the cases. The most common association is of warty and basaloid tumors, two HPV-related carcinomas. Here, we described a mixed papillary-sarcomatoid carcinoma, never reported before. Although it is a clinical aspect of a low-grade verruciform tumor, its prognosis showed it to be very aggressive due to the sarcomatoid component hidden above the papillary component...
July 8, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28660220/f-18-fdg-pet-ct-imaging-of-eccrine-sweat-gland-carcinoma-of-the-scrotum-with-extensive-regional-and-distant-metastases
#3
Jin-Suk Kim
Eccrine carcinoma is an extremely rare malignant skin cancer arising from eccrine sweat glands with a high metastatic potential. It mainly occurs in the elderly, with equal incidence in both sexes. It usually spreads to regional lymph nodes, with liver, lungs, and bones being the most common sites of distant metastasis. Because of tumor rarity, little is known about the value of F-18 FDG PET/CT in evaluating this disease. Our case report aims to increase current knowledge of F-18 FDG PET/CT in eccrine sweat gland carcinoma as a noninvasive imaging tool for assessing the extension of the disease and detecting distant metastases...
2017: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/28561704/new-developments-and-challenges-in-rare-genitourinary-tumors-non-urothelial-bladder-cancers-and-squamous-cell-cancers-of-the-penis
#4
Jeanny B Aragon-Ching, Lance C Pagliaro
The diagnosis and treatment of rare genitourinary tumors is inherently challenging. The Rare Diseases Act of 2002 initially defined a rare disorder as one that affects fewer than 200,000 Americans. The lack of widely available clinical guidelines, limited research funding, and inaccessible clinical trials often lead to difficulty with treatment decisions to guide practitioners in rendering effective care for patients with rare genitourinary cancers. This article will discuss basic tenets of diagnosis and treatment as well as recent developments and clinical trials in rare non-urothelial bladder cancers and penile squamous cell cancers...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28551383/a-exceptional-collision-tumor-of-primary-adrenal-angiosarcoma-and-non-functioning-adrenocortical-adenoma
#5
Katsumi Takizawa, Kenichi Kohashi, Takahito Negishi, Kenichi Taguchi, Yuichi Yamada, Motonobu Nakamura, Yoshinao Oda
Primary adrenal angiosarcoma is an extremely rare vascular tumor. We report a case of a 63-year-old man with a collision tumor of epithelioid angiosarcoma and adrenocortical adenoma of the right adrenal gland. The adrenal tumor was incidentally observed by a preoperative computed tomography (CT) scan of penis squamous cell carcinoma. The patient underwent a right laparoscopic adrenalectomy, and the tumor size measured 34×34×15mm. Histological examination revealed two different tumor cell proliferations, namely epithelioid angiosarcoma and adrenocortical adenoma...
June 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28533650/extensive-visceral-calcification-demonstrated-on-99m-tc-mdp-bone-scan-in-patient-with-carcinoma-penis-and-hypercalcemia-of-malignancy
#6
Sunny J Gandhi, Bhavdeep Rabadiya
Hypercalcemia is a common life-threatening complication associated with several malignancies. Parathyroid-related peptide has been shown to cause hypercalcemia in several solid tumors but rarely in penile cancer. We report a case of penile cancer with hypercalcemia causing metastatic visceral calcification in lungs, liver, and stomach detected on bone scan without significant abnormalities on CT scan.
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28501419/brachytherapy-for-conservative-treatment-of-invasive-penile-carcinoma-prognostic-factors-and-long-term-analysis-of-outcome
#7
Alexandre Escande, Christine Haie-Meder, Renaud Mazeron, Pierre Maroun, Andrea Cavalcanti, Renaud de Crevoisier, Antoine Schernberg, Fanny Marsolat, Pierre Blanchard, Florent Martinetti, Alberto Bossi, Isabelle Dumas, Eric Deutsch, Cyrus Chargari
PURPOSE: To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma. METHODS AND MATERIALS: We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy. RESULTS: With a median follow-up of 10.7 years, local relapse as first failure was reported in 37 patients (18.9%), and 24 of 31 patients (77...
February 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28476381/unusual-asymptomatic-presentation-of-bladder-cancer-metastatic-to-the-penis
#8
Francesca Giunchi, Francesco Vasuri, Vagnoni Valerio, Ilaria Montagnani, Federico Nelli, Michelangelo Fiorentino, Maria Rosaria Raspollini
Penile metastasis is an extremely rare event and mainly originate from primary pelvic tumor sites such us urinary bladder, gastro-intestinal tract and prostate and more rarely from respiratory system, bone tumors and melanoma. Here we describe the unusual presentation of two bladder urothelial cancer metastatic to the penis with no relevant clinical symptoms. Namely, a 69 years-old man with a warthy lesions of the foreskin and the glans misunderstood for a condylomata that at histological and immunohistochemical analysis showed a bladder urothelial carcinoma; and a 71 years-old man with reddish skin lesion of the glans, a previous history of bladder and urethral carcinoma and histological pagetoid spread of urothelial cancer to the glans...
June 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28417078/local-excision-for-the-treatment-of-penile-verrucous-carcinoma
#9
Dong In Jo, Sang Kyu Choi, Soon Heum Kim, Cheol Keun Kim, Hong Chung, Hong Sup Kim
Penile verrucous carcinoma is known for its favorable biologic behavior and lack of metastatic potential. For preservation of function, treatment has been focused on partial penectomy. Despite partial penectomy for preservation of minimal functional and aesthetic aspects, patients have experienced psychosexual problems. A 73-year-old man had a cauliflower-like verrucous carcinoma on the penile glans and coronary sulcus diagnosed by using excisional biopsy. He underwent degloving excision to save the penile shaft and glans penis...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28382926/aldosterone-induces-inflammatory-cytokines-in-penile-corpus-cavernosum-by-activating-the-nf-%C3%AE%C2%BAb-pathway
#10
Fei Wu, Zu-Quan Xiong, Shan-Hua Mao, Ji-Meng Hu, Jian-Qing Wang, Hao-Wen Jiang, Qiang Ding
Emerging evidence indicates that aldosterone and mineralocorticoid receptors (MRs) are associated with the pathogenesis of erectile dysfunction. However, the molecular mechanisms remain largely unknown. In this study, freshly isolated penile corpus cavernosum tissue from rats was treated with aldosterone, with or without MRs inhibitors. Nuclear factor (NF)-kappa B (NF-κB) activity was evaluated by real-time quantitative PCR, luciferase assay, and immunoblot. The results demonstrated that mRNA levels of the NF-κB target genes, including inhibitor of NF-κB alpha (IκB-α), NF-κB1, tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6), were higher after aldosterone treatment...
April 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28363474/disparity-between-pre-existing-management-of-penile-cancer-and-nccn-guidelines
#11
Rebecca A Campbell, Emily A Slopnick, Elizabeth K Ferry, Hui Zhu, Simon P Kim, Robert Abouassaly
OBJECTIVE: To determine the locoregional management of penile cancer before the introduction of NCCN guidelines and how much shift in practice patterns is required to meet the guidelines. METHODS: The National Cancer Data Base was queried to identify 6,396 patients with squamous cell carcinoma of the penis diagnosed between 2004 and 2013. The cohort was divided into management groups based on the NCCN guidelines: cTa and cTis (cTa/is), pT1 low grade (T1LG), pT1 high grade (T1HG), and pT2 or greater (T234)...
March 28, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28345835/evolution-of-the-histo-epidemiological-profile-of-urological-cancers-in-togo
#12
Tchin Darré, Koué Folligan, Tchilabalo Matchonna Kpatcha, Kokou Kanassoua, Edoe Sewa, Sassil Daré, Kodjo Tengue, Koffi Amégbor, Gado Napo Koura
Background: Urological cancers are an important public health issue and pose problems with diagnosis and adequate management in developing countries. Our aim was to determine and report epidemiological and histological features of urological cancers in Togo. Materials and methods: A retrospective descriptive study was conducted of cases of urological cancers observed in the laboratory of pathological anatomy of the CHU Tokoin over the last 4 years (2012-2016). The parameters studied were frequency, age, sex, sites of development and histological type...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28291123/medullary-carcinoma-of-the-penis-a-distinctive-hpv-related-neoplasm-a-report-of-12-cases
#13
Sofía Cañete-Portillo, Omar Clavero, Diego F Sanchez, Arturo Silvero, Francisco Abed, Ingrid M Rodriguez, Gustavo Ayala, Laia Alemany, Nubia Munoz, Silvia de Sanjose, Wim Quint, Francesc X Bosch, Antonio L Cubilla
A third to half of penile invasive squamous cell carcinomas are human papillomavirus (HPV) related. Warty (condylomatous), warty-basaloid, and basaloid carcinomas are the most common subtypes associated with HPV. Less frequent are clear cell and lymphoepithelioma-like carcinomas. Here we report a novel penile tumor associated with HPV. Twelve cases were selected from 1010 penile carcinomas, part of an international HPV detection study conducted at the Institut Català d'Oncologia, Barcelona, Spain. Immunostaining with p16 was performed on all cases, and HPV-mRNA detection was also performed...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28288040/incidentally-detected-penile-metastases-in-a-patient-of-carcinoma-urinary-bladder-on-follow-up-fdg-pet-ct
#14
Girish Kumar Parida, Sarthak Tripathy, Shambo Guha Roy, Abhinav Singhal, Chandanjyoti Das, Shamim Ahmed Shamim
Penis is an extremely uncommon site for metastases to occur and is often associated with very grave prognosis. Most of the secondary tumors originating in the penis have primaries from prostate, urinary bladder, and gastrointestinal tract. We hereby report a 65-year-old man, known case of carcinoma urinary bladder, who came for FDG PET/CT for metastatic workup. PET/CT study revealed FDG-avid mass lesion in the root and shaft of the penis, making it suggestive of metastases, which was confirmed later by MRI correlation...
May 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28209454/treatment-of-carcinoma-in-situ-of-the-glans-penis-with-topical-imiquimod-followed-by-carbon-dioxide-laser-excision
#15
Tullio Torelli, Mario A Catanzaro, Nicola Nicolai, Patrizia Giannatempo, Andrea Necchi, Daniele Raggi, Biagio Paolini, Maurizio Colecchia, Luigi Piva, Davide Biasoni, Silvia Stagni, Antonio Tesone, Roberto Salvioni
BACKGROUND: Different approaches have been described in published studies for carcinoma in situ (CIS) of the glans penis (erythroplasia of Queyrat), including topical chemotherapy or immunotherapy and laser or surgical excision. We evaluated the efficacy of topical imiquimod (IQ) followed by carbon dioxide laser ablation of the lesion. PATIENTS AND METHODS: From 2010 to 2015, 10 patients affected by CIS of the glans were treated by IQ, followed by carbon dioxide laser ablation...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28071635/prognostic-factors-and-5-year-survival-of-patients-with-carcinoma-penis-tertiary-health-center-study
#16
A A Shah, H A Shah, G N Panjwani, B B Pandey, N Shah
CONTEXT: To identify prognostic factors in carcinoma penis with its impact on survival. AIMS: To find out the relation of various prognostic factors of carcinoma penis with the various outcomes. SETTINGS AND DESIGN: Retrospective cohort study. SUBJECTS AND METHODS: Each patient diagnosed as having carcinoma of penis by incision biopsy and operated from January 2004 to May 2009 at the institute was included in the study (n = 117)...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27998313/embryonal-rhabdomyosarcoma-of-the-perineum-in-an-adult-a-case-report
#17
Sidy Ka, Freddy Gnangnon, Mamadou Moustapha Dieng, Doudou Diouf, Jaafar Thiam, Pape Macoumba Gaye, Ahmadou Dem
BACKGROUND: We report the case of an adult patient with embryonal rhabdomyosarcoma of the perineum admitted to our practice at Joliot Curie Institute in Dakar. It is a rare tumor at this age and has a bad prognosis at this localization. CASE PRESENTATION: We describe the case of a 22-year-old African man admitted for a perineal mass that had evolved over 6 months. He complained of tenesmus, obstinate constipation, and dysuria. A clinical examination revealed perineal swelling spread over his anus, scrotum, penis, testicles, and inguinal lymph nodes...
December 20, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27995080/electrochemotherapy-increases-local-control-after-incomplete-excision-of-a-recurring-penile-fibrosarcoma-in-a-stallion
#18
E P Spugnini, C Bolaffio, L Scacco, A Baldi
An eleven-year-old stallion was referred for adjuvant treatment of an incompletely excised, recurring penile fibrosarcoma. The horse was bright, alert and responsive with a 15 x 12 cm ulcerated lesion on the ventral side of the penis. The lesion was the tumor bed of an incompletely excised fibrosarcoma. After complete staging procedures, the owner elected to treat the horse with electrochemotherapy (ECT) using cisplatin as chemotherapy agent. Two sessions of ECT were performed at two-week intervals using local cisplatin followed by trains of biphasic electric pulses applied using different electrodes until complete coverage of the area was achieved...
2016: Open veterinary journal
https://www.readbyqxmd.com/read/27940757/atypical-leydig-cell-tumor-in-children-report-of-2-cases
#19
Chiara Mameli, Giorgio Selvaggio, Chiara Cerini, Gaetano Bulfamante, Cristina Madia, Giovanna Riccipetitoni, Gian Vincenzo Zuccotti
Leydig cell tumors (LCTs) are rare cord-stromal tumors that may occur in testis or ovaries and may produce androgens or estrogens. The majority has been found in men between the ages of 20 and 60 years. Adults with androgen-secreting LCTs are usually asymptomatic; feminizing syndromes may result from the production of estradiol or the peripheral aromatization of testosterone. In children, LCTs usually present between 5 and 10 years of age with isosexual precocious pseudopuberty or gynecomastia. We report 2 cases of LCT in prepubertal boys presenting with advanced unilateral pubarche and testicular volume asymmetry...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27867327/unusual-glomus-tumor-of-the-penis
#20
REVIEW
Gautam Dagur, Kelly Warren, Yimei Miao, Navjot Singh, Yiji Suh, Sardar A Khan
INTRODUCTION: Glomus tumors are benign neoplasms commonly found in subungual regions of the extremities and rarely located in the penis. Misdiagnosis of glomus tumors is common; therefore, symptoms and clinical presentations should be reviewed. OBJECTIVE: The primary objective of this review article is to emphasize the pathogenesis, pathology, clinical presentation, symptoms, diagnosis, and treatment methods of glomus tumors in order to better identify and manage the condition...
October 2016: Current Urology
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