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https://www.readbyqxmd.com/read/27913608/the-clinical-utility-of-circulating-neuroendocrine-gene-transcript-analysis-in-well-differentiated-paragangliomas-and-pheochromocytomas
#1
M Pęczkowska, J Cwikla, M Kidd, A Lewczuk, A Kolasinska-Ćwikła, D Niec, I Michałowska, A Prejbisz, A Januszewicz, J Chiarelli, L Bodei, I Modlin
CONTEXT: Paragangliomas and pheochromocytomas (PPGLs) exhibit variable malignancy, which is difficult to determine by histopathology, amine measurements or tissue genetic analyses. OBJECTIVE: To evaluate whether a 51-neuroendocrine gene blood analysis has clinical utility as a diagnostic and prognostic marker. DESIGN: Prospective cohort study. Well-differentiated PPGLs (n = 32), metastatic (n = 4); SDHx mutation (n = 25); 12 biochemically active, Lanreotide treated (n = 4)...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27900635/somatostatin-and-dopamine-receptor-regulation-of-pituitary-somatotroph-adenomas
#2
REVIEW
Anat Ben-Shlomo, Ning-Ai Liu, Shlomo Melmed
Somatostatin and dopamine receptors are expressed in normal and tumoral somatotroph cells. Upon receptor stimulation, somatostatin and the somatostatin receptor ligands octreotide, lanreotide, and pasireotide, and to a lesser extent, dopamine and the dopamine analogs bromocriptine and cabergoline, suppress growth hormone (GH) secretion from a GH-secreting pituitary somatotroph adenoma. Somatostatin and dopamine receptors are Gαi-protein coupled that inhibit adenylate cyclase activity and cAMP production and reduce intracellular calcium concentration and calcium flux oscillations...
November 29, 2016: Pituitary
https://www.readbyqxmd.com/read/27874199/glucose-and-lipids-levels-with-lanreotide-autogel-120-mg-in-treatment-na%C3%A3-ve-patients-with-acromegaly-data-from-the-primarys-study
#3
Philippe J Caron, Stephan Petersenn, Aude Houchard, Caroline Sert, John S Bevan
OBJECTIVE: Impaired glycaemic control, characteristic of acromegaly, can be exacerbated by treatment with somatostatin analogues (SSAs), particularly those with multireceptor activity. We present data from the PRIMARYS study on the impact of the SSA lanreotide, associated with tumour volume and hormonal improvements, on glucose and other metabolic parameters in acromegaly. DESIGN: PRIMARYS was a 48-week open-label single-arm phase-3b study of lanreotide autogel 120mg/4 weeks...
November 22, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27857269/neuroendocrine-tumors-and-lanreotide-depot-clinical-considerations-and-nurse-and-patient-preferences
#4
Pamela Ryan, Alexandria T Phan, Daphne T Adelman, Michiko Iwasaki
BACKGROUND: Somatostatin analogs (SSAs) are a mainstay therapy for the treatment of carcinoid syndrome associated with neuroendocrine tumors (NETs). They are effective for a range of gastroenteropancreatic NETs (GEP-NETs). Lanreotide depot (Somatuline®) is an SSA that is approved for the treatment of GEP-NETs to improve progression-free survival (PFS). OBJECTIVES: The article reviews the efficacy, safety, and administration of lanreotide depot and relates those attributes to considerations and preferences of oncology nurses and their patients...
December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27822010/clinical-utility-of-lanreotide-autogel-%C3%A2-in-gastroenteropancreatic-neuroendocrine-tumors
#5
REVIEW
Rosa Maria Paragliola, Alessandro Prete, Giampaolo Papi, Francesco Torino, Andrea Corsello, Alfredo Pontecorvi, Salvatore Maria Corsello
Somatostatin analogs (SSAs), which were initially used to control hormonal syndromes associated with neuroendocrine neoplasms (NENs), have been successfully proposed as antiproliferative agents, able to control tumor growth in patients affected by gastroenteropancreatic (GEP)-NENs. The development of long-acting formulations of SSAs which require only weekly or monthly injections can improve patient compliance. In particular, lanreotide (LAN) Autogel(®), which is a viscous aqueous formulation supplied in ready-to-use prefilled syringes, can be administered every 28-56 days...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27778296/somatostatin-receptor-ligands-in-acromegaly-clinical-response-and-factors-predicting-resistance
#6
Rosa Maria Paragliola, Salvatore Maria Corsello, Roberto Salvatori
INTRODUCTION: Somatostatin (SST) receptor ligands (SRL), in particular those of first generation (Octreotide and Lanreotide), are widely used in medical treatment of acromegaly, but they assure biochemical control of disease (and the possibility of an improvement of clinical symptoms and tumor shrinkage), only in a subset of patients. DISCUSSION: The mechanisms underlying the so called "SRL resistance" are various and involve in particular SST receptor expression and molecular pathways of signal transduction...
October 24, 2016: Pituitary
https://www.readbyqxmd.com/read/27769969/management-of-neuroendocrine-tumors
#7
REVIEW
Clement Chung
PURPOSE: Current strategies for managing neuroendocrine tumors (NETs) in adult patients are reviewed, with a focus on medication safety concerns. SUMMARY: NETs usually originate in the gastrointestinal or bronchopulmonary tract. Symptoms due to hormonal hypersecretion often occur in patients with foregut or midgut NETs or liver metastases. Surgical resection is recommended for most localized NETs, while systemic cytotoxic chemotherapy is typically used for high-grade and pancreatic tumors...
November 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27721778/unresectable-recurrent-multiple-meningioma-a-case-report-with-radiological-response-to-somatostatin-analogues
#8
Ana Ortolá Buigues, Irene Crespo Hernández, Manuela Jorquera Moya, Jose Ángel Díaz Pérez
Medical treatment of meningiomas is reserved for cases in which surgery and radiotherapy have failed. Given that a high percentage of meningiomas express somatostatin receptors, treatment with somatostatin analogues has been proposed. In addition, these medications have been shown to have an antiproliferative and antiangiogenic effect in vitro. To date, very few cases with clinical response and none with radiological response have been described. The case described here is the first to report a radiological response...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27697899/somatostatin-analogues-in-acromegaly-and-gastroenteropancreatic-neuroendocrine-tumours-past-present-and-future
#9
REVIEW
Kjell Öberg, Steven W J Lamberts
Acromegaly is a hormonal disorder that arises when the pituitary gland secretes excess growth hormone (GH), which in turn stimulates a concomitant increase in serum insulin-like growth factor 1 (IGF-1) levels. Gastroenteropancreatic neuroendocrine tumours (GEP-NET) constitute a heterogeneous group of tumours that can secrete serotonin and a variety of peptide hormones that may cause characteristic symptoms known as carcinoid syndrome or other symptoms and hormonal hypersecretion syndromes depending on the tumour's site of origin...
December 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27697568/somatostatin-analogues-compared-to-placebo-and-other-pharmacological-agents-in-the-management-of-symptoms-of-inoperable-malignant-bowel-obstruction-a-systematic-review
#10
George P Obita, Elaine G Boland, David C Currow, Miriam J Johnson, Jason W Boland
CONTEXT: Somatostatin analogues are commonly used to relieve symptoms in malignant bowel obstruction (MBO) but are more expensive than other anti-secretory agents. OBJECTIVE: To evaluate the evidence of effectiveness of somatostatin analogues compared to placebo and/or other pharmacological agents in relieving vomiting in patients with inoperable MBO. METHOD: MEDLINE, EMBASE, CINAHL, The Cochrane Controlled Trials Register databases were systematically searched; reference lists of relevant articles were hand-searched...
September 30, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27682353/clinical-outcomes-and-self-reported-symptoms-in-patients-with-acromegaly-eight-year-follow-up-of-a-lanreotide-study
#11
Shafaq Khairi, Babak Torabi Sagvand, Karen J Pulaski-Liebert, Nicholas A Tritos, Anne Klibanski, Lisa B Nachtigall
OBJECTIVES: The aim of this study was to evaluate the proportion of patients with acromegaly who remained on long-term lanreotide depot after completion of an open label multicenter phase III clinical trial (SALSA), compare symptom score at long-term follow-up with baseline and correlate these with individual longitudinal clinical outcomes. METHODS: Records of all subjects previously enrolled at the Massachusetts General Hospital site of SALSA were reviewed. Those who remained on lanreotide were interviewed and asked to complete a questionnaire that they had completed in SALSA in 2007 regarding their current symptomatology and injection side effects as well as to complete the Acromegaly Quality of life questionnaire...
September 28, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27635672/treatment-of-symptomatic-neuroendocrine-tumor-syndromes-recent-advances-and-controversies
#12
Tetsuhide Ito, Lingaku Lee, Robert T Jensen
INTRODUCTION: Neuroendocrine tumors(NETs), once thought rare, are increasing in frequency in most countries and receiving increasing-attention. NETs present two-treatment problems. A proportion is aggressive and a proportion has a functional, hormone-excess-state(F-NET) each of which, must be treated. Recently, there have been many advances, well-covered in reviews/consensus papers on imaging-NETs; new, novel anti-tumor treatments and understanding their pathogenesis. However, little attention has been paid to advances in the treatment of the hormone-excess-state...
September 16, 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27633684/peptide-therapeutics-and-the-pharmaceutical-industry-barriers-encountered-translating-from-the-laboratory-to-patients
#13
John Rafferty, Hema Nagaraj, Alice P McCloskey, Rawan Huwaitat, Simon Porter, Alyaa Albadr, Garry Laverty
Peptides are receiving increasing interest as clinical therapeutics. These highly tunable molecules can be tailored to achieve desirable biocompatibility and biodegradability with simultaneously selective and potent therapeutic effects. Despite challenges regarding up-scaling and licensing of peptide products, their vast clinical potential is reflected in the 60 plus peptide-based therapeutics already on the market, and the further 500 derivatives currently in developmental stages. Peptides are proving effective for a multitude of disease states including: type 2 diabetes (controlled using the licensed glucagon-like peptide-1 receptor liraglutide); irritable bowel syndrome managed with linaclotide (currently at approval stages); acromegaly (treated with octapeptide somostatin analogues lanreotide and octreotide); selective or broad spectrum microbicidal agents such as the Gram-positive selective PTP-7 and antifungal heliomicin; anticancer agents including goserelin used as either adjuvant or monotherapy for prostate and breast cancer, and the first marketed peptide derived vaccine against prostate cancer, sipuleucel-T...
September 9, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27619395/lanreotide-depot-an-antineoplastic-treatment-of-carcinoid-or-neuroendocrine-tumors
#14
REVIEW
Edward M Wolin, Amandine Manon, Christophe Chassaing, Andy Lewis, Laurent Bertocchi, Joel Richard, Alexandria T Phan
PURPOSE: Peptide drugs for antineoplastic therapies usually have low oral bioavailability and short in vivo half-lives, requiring less preferred delivery methods. Lanreotide depot is a sustained-release somatostatin analog (SSA) formulation produced via an innovative peptide self-assembly method. Lanreotide is approved in the USA and Europe to improve progression-free survival (PFS) in patients with unresectable gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and also approved in Europe for symptom control in carcinoid syndrome associated with GEP-NETs...
December 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27534781/-antiproliferative-effect-of-somatostatin-analogs-%C3%A2-data-analyses-and-clinical-applications-in-the-context-of-the-clarinet-study
#15
B Bencsiková
BACKGROUND: Somatostatin analogs (SSAs) are antisecretory agents that have been used to control hormonal syndromes associated with neuroendocrine tumors for more than 20 years. Recent phase III randomized, placebo controlled trials demonstrated their antiproliferative effects. The PROMID study showed that octreotide LAR (long-acting repeatable) treatment had anti-tumor effects. CLARINET, an international multicenter controlled study, provides new evidence that lanreotide has antiproliferative effects...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27459532/proteomics-suggests-a-role-for-apc-survivin-in-response-to-somatostatin-analog-treatment-of-neuroendocrine-tumors
#16
Omid Fotouhi, Hanna Kjellin, Catharina Larsson, Jamileh Hashemi, Jorge Barriuso, C Christofer Juhlin, Ming Lu, Anders Höög, Laura G Pastrián, Angela Lamarca, Victoria Heredia Soto, Jan Zedenius, Marta Mendiola, Janne Lehtiö, Magnus Kjellman
CONTEXT: Somatostatin analogs are established in the treatment of neuroendocrine tumors (NETs) including small intestinal NET; however, the molecular mechanisms are not well known. Here, we examined the direct effects of lanreotide in NET cell line models. SETTING AND DESIGN: The cell lines HC45 and H727 were treated with 10nM lanreotide for different time periods and alterations of the proteome were analyzed by in-depth high-resolution isoelectric focusing tandem liquid chromatography-mass spectrometry...
October 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27448708/use-of-lanreotide-in-combination-with-cabergoline-or-pegvisomant-in-patients-with-acromegaly-in-the-clinical-practice-the-acrocomb-study
#17
Manuel Puig-Domingo, Alfonso Soto, Eva Venegas, Ricardo Vilchez, Concepción Blanco, Fernando Cordido, Tomás Lucas, Mónica Marazuela, Rosa Casany, Guillem Cuatrecasas, Carmen Fajardo, María Ángeles Gálvez, Silvia Maraver, Tomás Martín, Enrique Romero, Miguel Paja, Antonio Picó, Ignacio Bernabeu, Eugenia Resmini
PURPOSE: To describe real-world use of lanreotide combination therapy for acromegaly. PATIENTS AND METHODS: ACROCOMB is a retrospective observational Spanish study of patients with active acromegaly treated with lanreotide combination therapy between 2006 and 2011. 108 patients treated at 44 Spanish Endocrinology Departments were analyzed separately: 61 patients received lanreotide/cabergoline (cabergoline cohort) and 47 lanreotide/pegvisomant (pegvisomant cohort)...
October 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/27432816/the-value-of-an-acute-octreotide-suppression-test-in-predicting-short-term-efficacy-of-somatostatin-analogues-in-acromegaly
#18
Meng Wang, Ming Shen, Wenqiang He, Yeping Yang, Wenjuan Liu, Yun Lu, Zengyi Ma, Zhao Ye, Yichao Zhang, Xiaolong Zhao, Bin Lu, Ji Hu, Yun Huang, Xuefei Shou, Yongfei Wang, Hongying Ye, Yiming Li, Shiqi Li, Yao Zhao, Zhaoyun Zhang
Predicting the efficacy of long-acting somatostatin analogues (SSA) remains a challenge. We aim to quantitatively evaluate the predictive value of the octreotide suppression test (OST) in short-term efficacy of SSA in active acromegaly. Sixty-seven newly diagnosed acromegaly patients were assessed with OST. Subsequently, all patients were treated with long-acting SSA for 3 months, followed by reassessment. Nine parameters were tested, including GHn (the nadir GH during OST), ΔGH1 (= [GH0h-GHn]/GH0h, GH0h was the baseline GH during OST), ΔGH2 (= [GHm-GHn]/GHm, GHm was the mean GH on day curve), AUC(0-6h) (the GH area under the curve during OST) , ΔAUC1 (= [GH0h-AUC(0-6h)]/GH0h), ΔAUC2 (=[GHm-AUC(0-6h)]/GHm), AUC(m-6h) (the GH AUC during OST where GHm was used instead of GH0h), ΔAUC1' (=[GH0h-AUC(m-6h)]/GH0h) and ΔAUC2' (=[GHm-AUC(m-6h)]/GHm)...
September 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27423779/lanreotide-autogel-in-the-treatment-of-idiopathic-refractory-diarrhea-results-of-an-exploratory-controlled-before-and-after-open-label-multicenter-prospective-clinical-trial
#19
Raf Bisschops, Vincent De Ruyter, Gauthier Demolin, Didier Baert, Tom Moreels, Piet Pattyn, Hans Verhelst, Luc Lepoutre, Joris Arts, Philip Caenepeel, Patrick Ooghe, Thierry Codden, Pascal Maisonobe, Elke Petrens, Jan Tack
PURPOSE: Chronic idiopathic diarrhea is the passage of loose stools >3 times daily, or a stool weight >200 g/d, persisting for >4 weeks without clear clinical cause. Patients refractory to standard anti-diarrhetics have limited treatment options. Somatostatin analogues have the ability to reduce gastrointestinal secretions and motility. This study evaluated the efficacy and safety of lanreotide Autogel(*) 120 mg in chronic idiopathic diarrhea. METHODS: Other anti-diarrhetics were not allowed during the study and were stopped at screening...
August 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27376425/beneficial-effect-of-dose-escalation-and-surgical-debulking-in-patients-with-acromegaly-treated-with-somatostatin-analogs-in-a-romanian-tertiary-care-center
#20
Monica Livia Gheorghiu, Simona Găloiu, Mădălina Vintilă, Mariana Purice, Dan Hortopan, Anda Dumitraşcu, Mihail Coculescu, Cătălina Poiană
BACKGROUND: Somatostatin analogs (SSA) are now considered standard therapy for acromegaly, as primary or adjunctive treatment after pituitary surgery. OBJECTIVE: To evaluate the efficacy of SSA and the effect of dose escalation in non-operated patients with acromegaly as compared to patients treated after pituitary surgery in a Romanian tertiary care center. DESIGN: Retrospective study of 73 consecutively evaluated patients with acromegaly treated with SSA, divided into 2 groups: 11 patients (4M/7F, 21-62 years) with primary treatment and 62 patients (22M/40F, 21-68 years) treated after surgery...
April 2016: Hormones: International Journal of Endocrinology and Metabolism
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