keyword
MENU ▼
Read by QxMD icon Read
search

Double carbapenem

keyword
https://www.readbyqxmd.com/read/27933276/acinetobacter-baumannii-isolated-from-lebanese-patients-phenotypes-and-genotypes-of-resistance-clonality-and-determinants-of-pathogenicity
#1
Elias Dahdouh, Micheline Hajjar, Monica Suarez, Ziad Daoud
Introduction:Acinetobacter baumannii is a nosocomial pathogen that usually affects critically ill patients. High mortality rates have been associated with MDR A. baumannii infections. Carbapenem resistance among these isolates is increasing worldwide and is associated with certain International Clones (ICs) and oxacillinases (OXAs). Moreover, this organism possesses a wide range of virulence factors, whose expression is not yet fully understood. In this study, clinical A. baumannii isolates are characterized in terms of antibiotic resistance, mechanisms of carbapenem resistance, clonality, and virulence...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27851857/assessing-the-efficacy-and-safety-of-eravacycline-vs-ertapenem-in-complicated-intra-abdominal-infections-in-the-investigating-gram-negative-infections-treated-with-eravacycline-ignite-1-trial-a-randomized-clinical-trial
#2
Joseph Solomkin, David Evans, Algirdas Slepavicius, Patrick Lee, Andrew Marsh, Larry Tsai, Joyce A Sutcliffe, Patrick Horn
Importance: Eravacycline is a novel, fully synthetic fluorocycline antibiotic of the tetracycline class with in vitro activity against clinically important gram-negative, gram-positive aerobic, and facultative bacteria including most of those resistant to cephalosporins, fluoroquinolones, β-lactam/β-lactamase inhibitors, multidrug resistant strains and carbapenem-resistant Enterobacteriaceae, and most anaerobic pathogens. Objective: To evaluate the efficacy and safety of eravacycline compared with ertapenem in adult hospitalized patients with complicated intra-abdominal infections (cIAIs)...
November 16, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27842873/in-vitro-activities-of-colistin-tigecycline-and-tobramycin-alone-or-in-combination-against-carbapenem-resistant-enterobacteriaceae-strains
#3
Berna Ozbek, Emel Mataracı-Kara, Sevda Er, Melda Ozdamar, Mesut Yilmaz
The aim of this study was to investigate the activities of various antibiotics, alone or in combination, against carbapenem-resistant Enterobacteriaceae (CRE). Minimum inhibitory concentrations (MICs) of meropenem, colistin, tigecycline and tobramycin were determined by microbroth dilution against 40 clinical strains. Carbapenemase-encoding genes were detected by PCR using specific primers. The in vitro synergistic activities of tigecycline, colistin and tobramycin in double antibiotic combinations were determined by the microbroth chequerboard technique, and results were interpreted using the fractional inhibitory concentration index (FICI)...
December 2015: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27821448/optimization-of-synergistic-combination-regimens-against-carbapenem-and-aminoglycoside-resistant-clinical-pseudomonas-aeruginosa-isolates-via-mechanism-based-pharmacokinetic-pharmacodynamic-modeling
#4
Rajbharan Yadav, Jürgen B Bulitta, Roger L Nation, Cornelia B Landersdorfer
Optimizing antibiotic combinations is promising to combat multidrug-resistant Pseudomonas aeruginosa This study aimed to systematically evaluate synergistic bacterial killing and resistance prevention by carbapenem and aminoglycoside combinations, and to rationally optimize combination dosage regimens via mechanism-based modeling (MBM). We studied monotherapies and combinations of imipenem with tobramycin or amikacin against three difficult-to-treat double-resistant clinical P. aeruginosa isolates. Viable count profiles of total and resistant populations were quantified in 48h static-concentration time-kill studies (inoculum: 10(7...
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27777535/open-conversion-after-aortic-endograft-infection-caused-by-colistin-resistant-carbapenemase-producing-klebsiella-pneumoniae
#5
Nunzio Montelione, Danilo Menna, Pasqualino Sirignano, Laura Capoccia, Wassim Mansour, Francesco Speziale
A 62-year-old man presented with fever, abdominal pain, and malaise 13 months after emergency endovascular aortic repair. Computed tomographic angiograms showed a periprosthetic fluid and gas collection, so infection was diagnosed. Open conversion was performed, involving endograft explantation and in situ aortic reconstruction. Cultures and the explanted prosthesis were positive for carbapenemase-producing Klebsiella pneumoniae, resistant to colistin. Because of the sparse data on endograft infections caused by this pathogen, we placed the patient on an empiric double-carbapenem regimen for 4 weeks...
October 2016: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/27686471/targeted-de-escalation-rounds-may-effectively-and-safely-reduce-meropenem-use
#6
U Ni Riain, M Tierney, C Doyle, A Vellinga, C Fleming, M Cormican
OBJECTIVE: Use of meropenem in our hospital has doubled in recent years. An audit in 2013 showed that although initiation of therapy with meropenem was generally appropriate, therapy was rarely subsequently reviewed and de-escalated where appropriate. Therefore, a structured stewardship initiative focussed on meropenem de-escalation was developed. METHODS: A local guideline for review and de-escalation of meropenem was developed and approved by the Antimicrobial Stewardship Team...
September 29, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27659436/carbapenem-resistant-enterobacteriaceae-prevalence-and-risk-factors-in-a-single-community-based-hospital-in-korea
#7
Hyo Jin Lee, Jae Ki Choi, Sung Yeon Cho, Si Hyun Kim, Sun Hee Park, Su Mi Choi, Dong Gun Lee, Jung Hyun Choi, Jin Hong Yoo
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) are Gram-negative bacteria with increasing prevalence of infection worldwide. In Korea, 25 cases of CPE isolates were reported by the Korea Centers for Disease Control and Prevention in 2011. Most CPE cases were detected mainly at tertiary referral hospitals. We analyzed the prevalence and risk factors for carbapenem-resistant Enterobacteriaceae (CRE) in a mid-sized community-based hospital in Korea. MATERIALS AND METHODS: We retrospectively analyzed all consecutive episodes of Enterobacteriaceae in a mid-sized community-based hospital from January 2013 to February 2014...
September 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27624572/polymyxin-monotherapy-or-in-combination-against-carbapenem-resistant-bacteria-systematic-review-and-meta-analysis
#8
Oren Zusman, Sergey Altunin, Fidi Koppel, Yael Dishon Benattar, Habip Gedik, Mical Paul
OBJECTIVES: The objective of this study was to summarize available data on polymyxin-based combination therapy or monotherapy for carbapenem-resistant Gram-negative bacteria. METHODS: This is a systematic review. We included observational studies and randomized controlled trials (RCTs) comparing polymyxin monotherapy versus polymyxin-based combination therapy in adult patients with infections caused by carbapenem-resistant or carbapenemase-producing Gram-negative bacteria...
September 13, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27540456/characterization-of-oxacillinase-and-metallo-%C3%AE-lactamas-genes-and-molecular-typing-of-clinical-isolates-of-acinetobacter-baumannii-in-ahvaz-south-west-of-iran
#9
Saeed Shoja, Mojtaba Moosavian, Soodabeh Rostami, Fariba Abbasi, Mohammad Amin Tabatabaiefar, Amir Peymani
BACKGROUND: Carbapenem resistant Acinetobacter baumannii is an important nosocomial pathogen associated with a variety of infections. OBJECTIVES: The current study aimed to characterize the antimicrobial susceptibility, analyze the prevalence of oxacillinase and metallo-β-lactamase (MBL) genes and molecular typing of clinical isolates of A. baumannii. MATERIALS AND METHODS: A total of 124 non-repetitive isolates of A. baumannii were collected from various clinical specimens in two teaching hospitals in Ahvaz, south-west of Iran...
May 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27530858/faecal-carriage-rate-of-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-hospitalised-patients-and-healthy-asymptomatic-individuals-coming-for-health-check-up
#10
Rachana Babu, Anil Kumar, Shamsul Karim, Sruthi Warrier, Suresh G Nair, Sanjeev K Singh, Raja Biswas
The prevalence of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) in hospitalised and community patients is of significant public health concern. The aim of this study was to estimate the faecal carriage rate of ESBL-PE in hospitalised patients and healthy asymptomatic individuals coming for health check-up. Non-repetitive, consecutive stool samples from 480 adults (260 healthy individuals and 220 hospitalised patients) aged ≥18 years from November 2011 to July 2013 were screened using MacConkey agar supplemented with ceftazidime...
September 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27527080/phase-1-study-of-the-safety-tolerability-and-pharmacokinetics-of-the-%C3%AE-lactamase-inhibitor-vaborbactam-rpx7009-in-healthy-adult-subjects
#11
David C Griffith, Jeffery S Loutit, Elizabeth E Morgan, Stephanie Durso, Michael N Dudley
Vaborbactam (formerly RPX7009) is a member of a new class of β-lactamase inhibitor with pharmacokinetic properties similar to those of many β-lactams, including carbapenems. The pharmacokinetics and safety of vaborbactam were evaluated in 80 healthy adult subjects in a first-in-human randomized, placebo-controlled, double-blind, sequential single- and multiple-ascending-dose study. A total of 10 dose cohorts were enrolled in the study, with 6 subjects randomized to receive 250 to 2,000 mg of vaborbactam and 2 subjects randomized to receive placebo in each cohort...
October 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27503659/phase-2-dose-ranging-study-of-relebactam-with-imipenem-cilastatin-in-subjects-with-complicated-intra-abdominal-infection
#12
Christopher Lucasti, Liviu Vasile, Dorel Sandesc, Donatas Venskutonis, Patrick McLeroth, Mallika Lala, Matthew L Rizk, Michelle L Brown, Maria C Losada, Alison Pedley, Nicholas A Kartsonis, Amanda Paschke
Relebactam (REL [MK-7655]) is a novel class A/C β-lactamase inhibitor intended for use with imipenem for the treatment of Gram-negative bacterial infections. REL restores imipenem activity against some resistant strains of Klebsiella and Pseudomonas In this multicenter, double-blind, controlled trial (NCT01506271), subjects who were ≥18 years of age with complicated intra-abdominal infection were randomly assigned (1:1:1) to receive 250 mg REL, 125 mg REL, or placebo, each given intravenously (i.v.) with 500 mg imipenem-cilastatin (IMI) every 6 h (q6h) for 4 to 14 days...
October 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27496451/urinary-tract-infections-in-kidney-transplant-recipients-hospitalized-at-a-transplantation-and-nephrology-ward-1-year-follow-up
#13
J Gozdowska, M Czerwińska, Ł Chabros, G Młynarczyk, A Kwiatkowski, A Chmura, M Durlik
INTRODUCTION: The aim of this study was to investigate risk factors for urinary tract infections (UTI), the causative organisms of UTI and also their management and treatment. In addition, we evaluated the effects of UTI on renal graft function. METHODS: This analysis included 107 kidney transplant recipients (64% women) with a diagnosis of UTIs confirmed by positive results on urine culture. Type of pathogens, sensitivity to drugs, risk factors for infection, incidence of urosepsis, hospitalization period, treatment methods, and recurrence rates were analyzed...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27334665/evaluation-of-antibacterial-activities-of-colistin-rifampicin-and-meropenem-combinations-against-ndm-1-producing-klebsiella-pneumoniae-in-24-h-in-vitro-time-kill-experiments
#14
P Lagerbäck, W W T Khine, C G Giske, T Tängdén
OBJECTIVES: To investigate the activity of colistin alone or in double and triple combination with rifampicin and meropenem against NDM-1-producing Klebsiella pneumoniae. METHODS: Eight isolates of NDM-1-producing K. pneumoniae were exposed to clinically relevant antibiotic concentrations in 24 h time-kill experiments. Three colistin concentrations were used for two of the strains. Resistance development was assessed with population analysis and sequencing of the mgrB and pmrB genes...
August 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27256585/molecular-mechanisms-of-membrane-impermeability-in-clinical-isolates-of-enterobacteriaceae-exposed-to-imipenem-selective-pressure
#15
Monica Pavez, Camila Vieira, Maria Rita de Araujo, Alvaro Cerda, Lara Mendes de Almeida, Nilton Lincopan, Elsa Masae Mamizuka
Intrinsic mechanisms leading to carbapenem-induced membrane impermeability and multidrug resistance are poorly understood in clinical isolates of Enterobacteriaceae. In this study, molecular behaviours during the establishment of membrane impermeability in members of the Enterobacteriaceae family under imipenem selective pressure were investigated. Clinical isolates (n = 22) exhibiting susceptibility to multiple antibiotics or characterised as extended-spectrum β-lactamase (ESBL)- or AmpC-producers were submitted to progressive passages on Mueller-Hinton agar plates containing subclinical concentrations of imipenem [0...
July 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27223840/travel-to-asia-and-traveller-s-diarrhoea-with-antibiotic-treatment-are-independent-risk-factors-for-acquiring-ciprofloxacin-resistant-and-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-a-prospective-cohort-study
#16
E A Reuland, G J B Sonder, I Stolte, N Al Naiemi, A Koek, G B Linde, T J W van de Laar, C M J E Vandenbroucke-Grauls, A P van Dam
Travel to (sub)tropical countries is a well-known risk factor for acquiring resistant bacterial strains, which is especially of significance for travellers from countries with low resistance rates. In this study we investigated the rate of and risk factors for travel-related acquisition of extended spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E), ciprofloxacin-resistant Enterobacteriaceae (CIPR-E) and carbapenem-resistant Enterobacteriaceae. Data before and after travel were collected from 445 participants...
August 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27208124/in-vivo-application-of-bacteriophage-as-a-potential-therapeutic-agent-to-control-oxa-66-like-carbapenemase-producing-acinetobacter-baumannii-strains-belonging-to-sequence-type-357
#17
Jongsoo Jeon, Choong-Min Ryu, Jun-Young Lee, Jong-Hwan Park, Dongeun Yong, Kyungwon Lee
UNLABELLED: The increasing prevalence of carbapenem-resistant Acinetobacter baumannii (CRAB) strains in intensive care units has caused major problems in public health worldwide. Our aim was to determine whether this phage could be used as an alternative therapeutic agent against multidrug-resistant bacterial strains, specifically CRAB clinical isolates, using a mouse model. Ten bacteriophages that caused lysis in CRAB strains, including blaOXA-66-like genes, were isolated. YMC13/01/C62 ABA BP (phage Bϕ-C62), which showed the strongest lysis activity, was chosen for further study by transmission electron microscopy (TEM), host range test, one-step growth and phage adsorption rate, thermal and pH stability, bacteriolytic activity test, genome sequencing and bioinformatics analysis, and therapeutic effect of phage using a mouse intranasal infection model...
July 15, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27123345/phenotypic-detection-of-metallo-beta-lactamases-in-carbapenem-resistant-acinetobacter-baumannii-isolated-from-pediatric-patients-in-pakistan
#18
Muneeza Anwar, Hassan Ejaz, Aizza Zafar, Hamdan Hamid
Multidrug resistant A. baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several types of infections especially in neonates and immunocompromised patients because they have least capacity to fight against infections. Carbapenems are used as last resort antibiotics for treating these infections but currently resistance against carbapenems due to MBL production is on the rise. The objective of this study was to determine the frequency of antibiotic resistance in A...
2016: Journal of Pathogens
https://www.readbyqxmd.com/read/27122379/multisite-evaluation-of-cepheid-xpert-carba-r-assay-for-detection-of-carbapenemase-producing-organisms-in-rectal-swabs
#19
M Tato, P Ruiz-Garbajosa, M Traczewski, A Dodgson, A McEwan, R Humphries, J Hindler, J Veltman, H Wang, R Cantón
Rapid identification of patients who are colonized with carbapenemase-producing organisms (CPO) is included in multiple national guidelines for containment of these organisms. In a multisite study, we evaluated the performance of the Cepheid Xpert Carba-R assay, a qualitative diagnostic test that was designed for the rapid detection and differentiation of the blaKPC, blaNDM, blaVIM, blaOXA-48, and blaIMP-1 genes from rectal swab specimens. A double rectal swab set was collected from 383 patients admitted at four institutions (2 in the United States, 1 in the United Kingdom, 1 in Spain)...
July 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27058056/antibiotic-resistance-patterns-and-a-survey-of-metallo-%C3%AE-lactamase-genes-including-bla-imp-and-bla-vim-types-in-acinetobacter-baumannii-isolated-from-hospital-patients-in-tehran
#20
Samira Aghamiri, Nour Amirmozafari, Jalil Fallah Mehrabadi, Babak Fouladtan, Mojtaba Hanafi Abdar
BACKGROUND: Metallo-β-lactamases (MBLs) producing strains of Acinetobacter baumannii are serious etiological agents of hospital infections worldwide. Among the β- lactams, carbapenems are the most effective antibiotics used against A. baumannii. However, resistance to these drugs among clinical strains of A. baumannii has been increasing in recent years. In this study, the antimicrobial sensitivity patterns of A. baumannii strains isolated from eleven different hospitals in Tehran, Iran, and the prevalence of MBL genes (bla-VIM and bla-IMP) were determined...
2016: Chemotherapy
keyword
keyword
81159
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"