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Gregory Handy, Marsa Taheri, John A White, Alla Borisyuk
We study evoked calcium dynamics in astrocytes, a major cell type in the mammalian brain. Experimental evidence has shown that such dynamics are highly variable between different trials, cells, and cell subcompartments. Here we present a qualitative analysis of a recent mathematical model of astrocyte calcium responses. We show how the major response types are generated in the model as a result of the underlying bifurcation structure. By varying key channel parameters, mimicking blockers used by experimentalists, we manipulate this underlying bifurcation structure and predict how the distributions of responses can change...
March 28, 2017: Journal of Computational Neuroscience
Ferran Marsa-Sambola, Joanne Williams, Janine Muldoon, Alistair Lawrence, Melanie Connor, Candace Currie
The relationship between adolescents' communication with their significant others (mother, father, and best friend) and quality of life (KIDSCREEN) was investigated in 2262 Scottish adolescent pet owners. The variable attachment to pets was also tested and assessed as a mediator of this relationship. A positive relationship between adolescents' communication with their significant other (mother, father, and best friend) and quality of life decreased when controlling for attachment to dogs. In cat owners, a positive relationship between communication with a best friend and quality of life decreased when controlling for attachment to cats...
February 20, 2017: Attachment & Human Development
Frederic Català, Ferran Marsà, Mario Montes-Usategui, Arnau Farré, Estela Martín-Badosa
Optical trapping has become an optimal choice for biological research at the microscale due to its non-invasive performance and accessibility for quantitative studies, especially on the forces involved in biological processes. However, reliable force measurements depend on the calibration of the optical traps, which is different for each experiment and hence requires high control of the local variables, especially of the trapped object geometry. Many biological samples have an elongated, rod-like shape, such as chromosomes, intracellular organelles (e...
February 21, 2017: Scientific Reports
Corinne M Doll, Jennifer Moughan, Alexander Klimowicz, Clement K Ho, Elizabeth N Kornaga, Susan P Lees-Miller, Jaffer A Ajani, Christopher H Crane, Lisa A Kachnic, Gordon S Okawara, Lawrence B Berk, Kevin S Roof, Mark J Becker, David L Grisell, Robert J Ellis, Paul W Sperduto, Gerald W Marsa, Chandan Guha, Anthony M Magliocco
PURPOSE: To measure co-expression of EGFR and Ki67 proteins in pretreatment tumor biopsies of anal cancer patients enrolled on NRG Oncology RTOG 9811, a phase III trial comparing 5-fluorouracil/mitomycin-C/radiation therapy (Arm A) versus 5-fluorouracil/cisplatin/radiation therapy (Arm B), and to correlate expression with clinical outcome. METHODS AND MATERIALS: EGFR and Ki67 co-expression was measured after constructing a tissue microarray using fluorescence immunohistochemistry and automated quantitative image analysis...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
Blanca Mellor-Marsá, Francisco Félix Caballero, María Cabello, José Luis Ayuso-Mateos, Esther Setién-Suero, Javier Vázquez-Bourgon, Benedicto Crespo-Facorro, Rosa Ayesa-Arriola
The description of longitudinal bio-psycho-social profiles in FEP samples may be useful for the prediction of disability trajectories. This study aimed to describe the differences between disability status of FEP patients at baseline and their change over time, analysing how variables associated to the psychological status, and the environment of the patient can affect his or her disability trajectory, once the influence of health condition and socio-demographic variables has been controlled for. Using data from a 3-year follow-up study on early psychosis (PAFIP), a multilevel structure in which the longitudinal measurements (within level) were nested within the individuals (between level), was modeled...
January 3, 2017: Schizophrenia Research
Mohamed Hedfi, Hassen Khouni, Youssra Massoudi, Cherif Abdelhedi, Karim Sassi, Adnen Chouchen
Background - The infections associated with care (IAS) constitute a major public health problem by the morbi- mortality than they generate as well as by their cost to support. The prevention of these infections has become a priority for several years everywhere in the world and in the occurrence in Tunisia. Aim - The purpose of our study is to assess the prevalence of nosocomial infections as well as develop their microbiologic  profiles in the different departments of  the hospital of FSI  Marsa Tunisia and try to highlight the risk factors that can influence these infections Methods - It was a retrospective study about  patients with noscomila infection who were admitted in the different care unit of the Hospital of FSI  Marsa and this on a period of 6 years from 1 January 2009 to 31 December 2014 Results - We have identified seventy(70) patients having contracted a nososcomial infection during the period of study for 24600 hospital admission, with a prevalence rate of 0...
July 2016: La Tunisie Médicale
Nerea Palomares, Antonia McMaster, Marina Díaz-Marsá, Irene de la Vega, Ana Montes, José Luis Carrasco
BACKGROUND: Current literature suggests that personality disorder comorbidity negatively contributes to both the severity and prognosis of other disorders; however, little literature has been devoted to its influence on borderline personality disorder (BPD). The objective of the present work is to study comorbidity with other personality disorders in a severe clinical sample of patients with BPD, and its relationship with global functionality. METHODS: A sample of 65 patients with severe borderline personality disorder was included in the study...
November 2016: Actas Españolas de Psiquiatría
Akbar Fazel-Tabar Malekshah, Marsa Zaroudi, Arash Etemadi, Farhad Islami, Sadaf Sepanlou, Maryam Sharafkhah, Abbas-Ali Keshtkar, Hooman Khademi, Hossein Poustchi, Azita Hekmatdoost, Akram Pourshams, Akbar Feiz Sani, Elham Jafari, Farin Kamangar, Sanford M Dawsey, Christian C Abnet, Paul D Pharoah, Paul J Berennan, Paolo Boffetta, Ahmad Esmaillzadeh, Reza Malekzadeh
BACKGROUND: Most studies that have evaluated the association between combined lifestyle factors and mortality outcomes have been conducted in populations of developed countries. OBJECTIVES: The aim of this study was to examine the association between combined lifestyle scores and risk of all-cause and cause-specific mortality for the first time among Iranian adults. METHODS: The study population included 50,045 Iranians, 40 - 75 years of age, who were enrolled in the Golestan Cohort Study, between 2004 and 2008...
November 2016: Archives of Iranian Medicine
Arnau Farré, Ferran Marsà, Mario Montes-Usategui
The ability to measure forces in the range of 0.1-100 pN is a key feature of optical tweezers used for biophysical and cell biological studies. Analysis of the interactions between biomolecules and the forces that biomolecular motors generate at the single-molecule level has provided valuable insights in the molecular mechanisms that govern key cellular functions such as gene expression and the long-distance transport of organelles. Methods for determining the minute forces that biomolecular motors generate exhibit notable constraints that limit their application for studies other than the well-controlled in vitro experiments (although recent advances have been made that permit more quantitative optical tweezers studies insight living cells)...
2017: Methods in Molecular Biology
Susel Fernandez, Rafik Hadfi, Takayuki Ito, Ivan Marsa-Maestre, Juan R Velasco
Intelligent transportation systems are a set of technological solutions used to improve the performance and safety of road transportation. A crucial element for the success of these systems is the exchange of information, not only between vehicles, but also among other components in the road infrastructure through different applications. One of the most important information sources in this kind of systems is sensors. Sensors can be within vehicles or as part of the infrastructure, such as bridges, roads or traffic signs...
2016: Sensors
Marsa Zaroudi, Jamshid Yazdani Charati, Sharmin Mehrabi, Elham Ghorbani, Jalal Norouzkhani, Hamid Shirashiani, Bahar Nikzad, Mirhossein Seiedpour, Morteza Izadi, Mohammadreza Mirzaei, Ghasem Oveis, Nader Ahangar, Hossein Azadeh, Ozra Akha, Akbar Fazel-Tabar Malekshah
OBJECTIVE: We aimed to assess the relationship between major dietary patterns and risk of diabetes type 2 among Iranian adults. METHODS: In this population-based case-control study in Mazandaran province, we enrolled 332 subjects (110 newly diagnosed cases and 222 controls) aged 43 - 77 years. Dietary intakes were collected using a validated semi-quantitative food frequency questionnaire (FFQ). Data on demographic, anthropometric, socioeconomic characteristics and other covariates were collected using structured lifestyle questionnaires...
March 2016: Archives of Iranian Medicine
Kazuhiro Tajima-Pozo, Camila Bayón, Marina Díaz-Marsá, Jose Luis Carrasco
OBJECTIVE: High plasma testosterone levels have been associated with aggression, sexual behaviour and social status. The aim of this paper was to study the correlation between basal plasma testosterone levels and personality variables in healthy participants. MATERIALS AND METHODS: Fifty-four participants were randomly enrolled into this study. Basal plasma testosterone levels were measured between 8:30 am and 10 am. After 24 hours of blood drawing, each subject completed personality questionnaires...
July 2015: Indian Journal of Psychological Medicine
Enrique de la Hoz, Jose Manuel Gimenez-Guzman, Ivan Marsa-Maestre, David Orden
Due to the low cost of CMOS IP-based cameras, wireless surveillance sensor networks have emerged as a new application of sensor networks able to monitor public or private areas or even country borders. Since these networks are bandwidth intensive and the radioelectric spectrum is limited, especially in unlicensed bands, it is mandatory to assign frequency channels in a smart manner. In this work, we propose the application of automated negotiation techniques for frequency assignment. Results show that these techniques are very suitable for the problem, being able to obtain the best solutions among the techniques with which we have compared them...
2015: Sensors
Juan C Pascual, Nerea Palomares, Ángela Ibáñez, Maria J Portella, Rocío Arza, Raquel Reyes, Albert Feliu-Soler, Marina Díaz-Marsá, Jerónimo Saiz-Ruiz, Joaquim Soler, Jose L Carrasco
BACKGROUND: Follow-up studies revealed that subjects with borderline personality disorder (BPD) present high rates of clinical remission, although psychosocial functioning often remains impaired. The aim of this study is to evaluate the efficacy of a cognitive rehabilitation intervention versus a psychoeducational program on psychosocial functioning in subjects with BPD. METHODS: A multicenter, randomized, and positive-controlled clinical trial was conducted. Seventy outpatients with BPD were randomized to cognitive rehabilitation or psychoeducational group interventions...
October 21, 2015: BMC Psychiatry
Nerea Palomares, Ana Montes, Marina Díaz-Marsá, José L Carrasco
The aim of the present study is to test the efficacy of palmitate paliperidone long-acting injection for patients with borderline personality disorder (BPD). A total of 16 patients with BPD were treated with intramuscular paliperidone palmitate (IMPP) over 12 weeks. Effectiveness measures included the CGI-BPD, HARS, MADRS, BIS-11, and STAXI-2. Functional improvement was assessed using the Global Assessment of Functioning scale. A list of adverse events was provided to clinicians and patients. Treatment with IMPP was associated with a significant average reduction of 1...
November 2015: International Clinical Psychopharmacology
Leila Saadatpour, Simin Hemati, Farzaneh Habibi, Erfan Behzadi, Marsa Sadat Hashemi-Jazi, Gholamreza Kheirabadi, Leila Mirbagher, Ali Gholamrezaei
CONTEXT: Various symptoms frequently affect cancer patients' quality of life. Appropriate assessment of these symptoms provides valuable data for cancer management. OBJECTIVES: This study aimed to validate the Persian version of the M. D. Anderson Symptom Inventory (MDASI-P). METHODS: This cross-sectional study was conducted at four cancer treatment centers in two cities in Iran. Breast cancer and colorectal cancer patients aged 18 years and older were consecutively included in the study...
September 2015: Journal of Pain and Symptom Management
J Michael Gee, Meredith B Gibbons, Marsa Taheri, Sierra Palumbos, S Craig Morris, Roy M Smeal, Katherine F Flynn, Michael N Economo, Christian G Cizek, Mario R Capecchi, Petr Tvrdik, Karen S Wilcox, John A White
Complex interactions between networks of astrocytes and neurons are beginning to be appreciated, but remain poorly understood. Transgenic mice expressing fluorescent protein reporters of cellular activity, such as the GCaMP family of genetically encoded calcium indicators (GECIs), have been used to explore network behavior. However, in some cases, it may be desirable to use long-established rat models that closely mimic particular aspects of human conditions such as Parkinson's disease and the development of epilepsy following status epilepticus...
2015: Frontiers in Molecular Neuroscience
Kaloyan Kamenov, Blanca Mellor-Marsá, Itziar Leal, Jose Luis Ayuso-Mateos, Maria Cabello
Despite all the knowledge on depression, it is still unclear whether current literature covers all the psychosocial difficulties (PSDs) important for depressed patients. The aim of the present study was to identify the gaps in the recent literature concerning PSDs and their related variables. Psychosocial difficulties were defined according to the World Health Organization International Classification of Functioning, Disability and Health (ICF). A comparative approach between a systematic literature review, a focus group, and individual interviews with depressed patients was used...
2014: BioMed Research International
Kaouther Dimassi, Anissa Ben Amor, Cyrine Belghith, Mohamed Amine Ben Khedija, Amel Triki, Mohamed Faouzi Gara
OBJECTIVE: To compare clinical data and transperineal ultrasound results for the diagnosis of fetal head engagement. METHODS: The present prospective longitudinal study enrolled 100 term women attending the Mongi Slim Hospital, La Marsa, Tunisia, between July and September 2012. The clinical assessment of fetal engagement was compared with ultrasound measurements. Ultrasound examination was performed in the delivery room. The probe was placed on the ano-vulvar area...
October 2014: International Journal of Gynaecology and Obstetrics
Ferran Marsà, Arnau Farré, Estela Martín-Badosa, Mario Montes-Usategui
A major problem with holographic optical tweezers (HOTs) is their incompatibility with laser-based position detection methods, such as back-focal-plane interferometry (BFPI). The alternatives generally used with HOTs, like high-speed video tracking, do not offer the same spatial and temporal bandwidths. This has limited the use of this technique in precise quantitative experiments. In this paper, we present an optical trap design that combines digital holography and back-focal-plane displacement detection. We show that, with a particularly simple setup, it is possible to generate a set of multiple holographic traps and an additional static non-holographic trap with orthogonal polarizations and that they can be, therefore, easily separated for measuring positions and forces with the high positional and temporal resolutions of laser-based detection...
December 16, 2013: Optics Express
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