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https://www.readbyqxmd.com/read/29435684/recurrence-free-survival-after-resection-of-gastric-gastrointestinal-stromal-tumors-classified-according-to-a-strict-definition-of-tumor-rupture-a-population-based-study
#1
Toto Hølmebakk, Ivar Hompland, Bodil Bjerkehagen, Stephan Stoldt, Øyvind Sverre Bruland, Kirsten Sundby Hall, Kjetil Boye
BACKGROUND: In gastrointestinal stromal tumors (GISTs), rupture is a high-risk feature and an indication for adjuvant treatment; however, the independent impact of rupture on prognosis is uncertain and the term is inconsistently defined. In the present study, a previously proposed definition of 'tumor rupture' was applied on a population-based cohort of gastric GISTs. METHODS: Patients undergoing surgery for non-metastatic gastric GISTs from 2000 to 2015 were identified in the regional sarcoma database of Oslo University Hospital...
February 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29432660/recent-gestational-diabetes-was-associated-with-mothers-stopping-predominant-breastfeeding-earlier-in-a-multi-ethnic-population
#2
Anne Baerug, Line Sletner, Petter Laake, Atle Fretheim, Beate Fossum Løland, Christin W Waage, Kåre I Birkeland, Anne Karen Jenum
AIM: It has previously been shown that breastfeeding may reduce the risk of type 2 diabetes in mothers with recent gestational diabetes mellitus (GDM). This study compared the cessation of predominant breastfeeding in mothers with and without recent GDM in a multi-ethnic population. METHODS: From May 2008 to May 2010, healthy pregnant women attending antenatal care provided by community health services in Eastern Oslo, Norway, were recruited. We included 616 women - 58% non-Western - and interviewed and examined them at a mean of 15 and 28 weeks of gestation and 14 weeks' postpartum...
February 12, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29429017/performance-of-breast-cancer-screening-using-digital-breast-tomosynthesis-results-from-the-prospective-population-based-oslo-tomosynthesis-screening-trial
#3
Per Skaane, Sofie Sebuødegård, Andriy I Bandos, David Gur, Bjørn Helge Østerås, Randi Gullien, Solveig Hofvind
PURPOSE: Digital breast tomosynthesis (DBT) has the potential to overcome limitations of conventional mammography. This study investigated the effects of addition of DBT on interval and detected cancers in population-based screening. METHODS: Oslo Tomosynthesis Screening Trial (OTST) was a prospective, independent double-reading trial inviting women 50-69 years biennially, comparing full-field digital mammography (FFDM) plus DBT with FFDM alone. Performance indicators and characteristics of screen-detected and interval cancers were compared with two previous FFDM rounds...
February 10, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29426122/analysis-of-stimulant-drugs-in-the-wastewater-of-five-nordic-capitals
#4
Arndís Sue Ching Löve, Jose Antonio Baz-Lomba, Malcolm J Reid, Aino Kankaanpää, Teemu Gunnar, Maria Dam, Kristín Ólafsdóttir, Kevin V Thomas
Wastewater-based epidemiology is an efficient way to assess illicit drug use, complementing currently used methods retrieved from different data sources. The aim of this study is to compare stimulant drug use in five Nordic capital cities that include for the first time wastewater samples from Torshavn in the Faroe Islands. Currently there are no published reports that compare stimulant drug use in these Nordic capitals. All wastewater samples were analyzed using solid phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry...
February 3, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29425210/seasonality-in-trauma-admissions-are-daylight-and-weather-variables-better-predictors-than-general-cyclic-effects
#5
Jo Røislien, Signe Søvik, Torsten Eken
BACKGROUND: Trauma is a leading global cause of death, and predicting the burden of trauma admissions is vital for good planning of trauma care. Seasonality in trauma admissions has been found in several studies. Seasonal fluctuations in daylight hours, temperature and weather affect social and cultural practices but also individual neuroendocrine rhythms that may ultimately modify behaviour and potentially predispose to trauma. The aim of the present study was to explore to what extent the observed seasonality in daily trauma admissions could be explained by changes in daylight and weather variables throughout the year...
2018: PloS One
https://www.readbyqxmd.com/read/29414485/assessing-the-effect-of-public-health-information-by-incentivised-risk-estimation-an-example-on-swedish-snus
#6
Daniel Bergsvik, Ole Rogeberg
BACKGROUND: The provision of accurate information on health damaging behaviours and products is a widely accepted and widespread governmental task. It is easily mismanaged. This study demonstrates a simple method which can help to evaluate whether such information corrects recipient risk beliefs. METHODS: Participants assess risks numerically, before and after being exposed to a relevant risk communication. Accuracy is incentivised by awarding financial prizes to answers closest to a pursued risk belief...
February 1, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29402700/chromatin-organisation-and-cancer-prognosis-a-pan-cancer-study
#7
Andreas Kleppe, Fritz Albregtsen, Ljiljana Vlatkovic, Manohar Pradhan, Birgitte Nielsen, Tarjei S Hveem, Hanne A Askautrud, Gunnar B Kristensen, Arild Nesbakken, Jone Trovik, Håkon Wæhre, Ian Tomlinson, Neil A Shepherd, Marco Novelli, David J Kerr, Håvard E Danielsen
BACKGROUND: Chromatin organisation affects gene expression and regional mutation frequencies and contributes to carcinogenesis. Aberrant organisation of DNA has been correlated with cancer prognosis in analyses of the chromatin component of tumour cell nuclei using image texture analysis. As yet, the methodology has not been sufficiently validated to permit its clinical application. We aimed to define and validate a novel prognostic biomarker for the automatic detection of heterogeneous chromatin organisation...
February 2, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29398522/-vaginal-hysterectomy-in-outpatient-procedure-feasibility-and-satisfaction-study
#8
Q Reboul, A Mehdi, C Chauleur
OBJECTIVES: To study the feasibility and patient satisfaction for vaginal hysterectomy in a new outpatient procedure. METHODS: This retrospective study was directed in CHU de Saint-Étienne, Loire, France. All patient who underwent a vaginal hysterectomy in outpatient procedure were included from January 2014 and January 2017. Descriptive data were collected and all patients were called back for satisfaction study. RESULTS: Sixty-five patients were included...
February 2, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29387447/prospective-monitoring-of-health-problems-among-recreational-runners-preparing-for-a-half-marathon
#9
Karsten Hollander, Antje Baumann, Astrid Zech, Evert Verhagen
Objectives: While the health benefits of running are legitimately advocated, participation in running can also lead to health problems. There is a high range of reported prevalence rates especially of running-related overuse injuries in high-level athletes and during competition. Little consensus exists for acute injuries and illnesses especially in recreational runners. Therefore, the aim of this study was to record the prevalence of health problems in recreational long-distance runners preparing for an event...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29385900/looking-to-the-future-of-nasal-drug-delivery-an-interview-with-per-gisle-djupesland
#10
Per G Djupesland
Per G Djupesland, MD, PhD speaks to Hannah Makin, Commissioning Editor: Dr Djupesland is the inventor of OptiNose®'s patented, bi-directional nasal drug-delivery technology and is a Co-Founder of OptiNose AS. Dr. Djupesland is a lead inventor on all 38 OptiNose patent families/patent applications, and serves as Chief Scientific Officer of OptiNose AS, with primary responsibility for device discovery and early development efforts. These early development efforts include identifying new product opportunities that use bi-directional technology, advancing the design of devices using the bi-directional technology to treat a variety of medical conditions and conducting Phase I and IIa trials with new 'nose-to-brain' applications for the technology...
February 1, 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29383600/the-role-of-surgery-in-intracranial-pcnsl
#11
Guro Jahr, Michele Da Broi, Harald Holte, Klaus Beiske, Torstein R Meling
This aimed to evaluate the effect of surgery for overall survival (OS) and progression-free survival (PFS) in intracranial primary CNS lymphoma (PCNSL) of all patients diagnosed at a single center. A prospective database at Oslo University Hospital of PCNSL was reviewed over a 12-year period (2003-2014). Seventy-nine patients with intracranial PCNSL were identified. Deep brain involvement was shown in 63 patients. Thirty-two patients underwent craniotomy with resection, while all other patients had a biopsy...
January 27, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29377400/injuries-in-dutch-elite-field-hockey-players-a-prospective-cohort-study
#12
S D Barboza, J Nauta, M van der Pols, W van Mechelen, E A L M Verhagen
This study describes the prevalence, incidence density, severity, and nature of injuries in elite field hockey players over the Dutch 2015-2016 season. Eighty players answered a baseline questionnaire and were subsequently followed-up every 2 weeks to report the hours spent on training/competition and experienced injuries, which were registered using the Oslo Sports Trauma Research Centre Questionnaire on Health Problems. Of the 74 players included in the analysis, 52 (70%) reported 112 injuries. Eighty-seven injuries (78%) received medical attention, and 56 (50%) led to training/competition time loss...
January 29, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29370197/changes-in-opiate-and-stimulant-use-through-10-years-the-role-of-contextual-factors-mental-health-disorders-and-psychosocial-factors-in-a-prospective-sud-treatment-cohort-study
#13
Grethe Lauritzen, Trond Nordfjærn
AIM: To examine temporal changes in opiate and stimulant use among patients in substance abuse treatment over a ten-year observation period and to explore the role of contextual factors, mental health disorders and psychosocial factors on these changes. METHODS: A cohort of 481 patients was prospectively interviewed at admission to treatment and after 1, 2, 7 and 10 years. The sample was recruited from 20 facilities in the Greater Oslo region, Norway. RESULTS: The majority of patients were poly-drug users and 80% had used both opiates and stimulants the last 30 days prior to treatment admission...
2018: PloS One
https://www.readbyqxmd.com/read/29363115/do-terrorist-attacks-affect-ethnic-discrimination-in-the-labour-market-evidence-from-two-randomized-field-experiments
#14
Gunn Elisabeth Birkelund, Tak Wing Chan, Elisabeth Ugreninov, Arnfinn H Midtbøen, Jon Rogstad
Terrorist attacks are known to influence public opinion. But do they also change behaviour? We address this question by comparing the results of two identical randomized field experiments on ethnic discrimination in hiring that we conducted in Oslo. The first experiment was conducted before the 2011 terrorist attacks in Norway; the second experiment was conducted after the attacks. In both experiments, applicants with a typical Pakistani name were significantly less likely to get a job interview compared to those with a typical Norwegian name...
January 24, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29359085/volumetric-fluorescence-retinal-imaging-in-vivo-over-a-30-degree-field-of-view-by-oblique-scanning-laser-ophthalmoscopy-oslo
#15
Lei Zhang, Weiye Song, Di Shao, Sui Zhang, Manishi Desai, Steven Ness, Sayon Roy, Ji Yi
While fluorescent contrast is widely used in ophthalmology, three-dimensional (3D) fluorescence retinal imaging over a large field of view (FOV) has been challenging. In this paper, we describe a novel oblique scanning laser ophthalmoscopy (oSLO) technique that provides 3D volumetric fluorescence retinal imaging with only one raster scan. The technique utilizes scanned oblique illumination and angled detection to obtain fluorescent cross-sectional images, analogous to optical coherence tomography (OCT) line scans (or B-scans)...
January 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29353072/development-of-subcortical-volumes-across-adolescence-in-males-and-females-a-multisample-study-of-longitudinal-changes
#16
Megan M Herting, Cory Johnson, Kathryn L Mills, Nandita Vijayakumar, Meg Dennison, Chang Liu, Anne-Lise Goddings, Ronald E Dahl, Elizabeth R Sowell, Sarah Whittle, Nicholas B Allen, Christian K Tamnes
The developmental patterns of subcortical brain volumes in males and females observed in previous studies have been inconsistent. To help resolve these discrepancies, we examined developmental trajectories using three independent longitudinal samples of participants in the age-span of 8-22 years (total 216 participants and 467 scans). These datasets, including Pittsburgh (PIT; University of Pittsburgh, USA), NeuroCognitive Development (NCD; University of Oslo, Norway), and Orygen Adolescent Development Study (OADS; The University of Melbourne, Australia), span three countries and were analyzed together and in parallel using mixed-effects modeling with both generalized additive models and general linear models...
January 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29341147/genotype-and-risk-of-tumour-rupture-in-gastrointestinal-stromal-tumour
#17
K Boye, J-M Berner, I Hompland, Ø S Bruland, S Stoldt, K Sundby Hall, B Bjerkehagen, T Hølmebakk
BACKGROUND: Tumour rupture is a strong predictor of poor outcome in gastrointestinal stromal tumours (GISTs) of the stomach and small intestine. The objective was to determine whether tumour genotype was associated with risk of rupture. METHODS: Rupture was classified according to the definition proposed by the Oslo Sarcoma Group. Since January 2000, data were registered retrospectively for all patients at Oslo University Hospital undergoing surgery for localized GIST of the stomach or small intestine...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29331055/the-challenges-and-possibilities-of-public-access-defibrillation
#18
REVIEW
Mattias Ringh, Jacob Hollenberg, Thea Palsgaard-Moeller, Leif Svensson, Mårten Rosenqvist, Freddy K Lippert, Mads Wissenberg, Carolina Malta Hansen, Andreas Claesson, Soren Viereck, Jolande A Zijlstra, Rudolph W Koster, Johan Herlitz, Marieke T Blom, Jo Kramer-Johansen, Hanno L Tan, Steffie Beesems, Michiel Hulleman, Theresa M Olasveengen, Fredrik Folke
Out-of-Hospital Cardiac Arrest (OHCA) is a major health problem that affects approximately four hundred thousand patients annually in the United States alone. It is a major challenge for the emergency medical system since decreased survival rates are directly proportional to the time delay from collapse to defibrillation. Historically, defibrillation has only been performed by physicians and in-hospital. With the development of automated external defibrillators (AEDs), rapid defibrillation by non-medical professionals and subsequently by trained or untrained lay bystanders has become possible...
January 13, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29325448/impact-of-cyp2c19-genotype-on-escitalopram-exposure-and-therapeutic-failure-a-retrospective-study-based-on-2-087-patients
#19
Marin M Jukić, Tore Haslemo, Espen Molden, Magnus Ingelman-Sundberg
OBJECTIVE: The antidepressant escitalopram is predominantly metabolized by the polymorphic CYP2C19 enzyme. The authors investigated the effect of CYP2C19 genotype on exposure and therapeutic failure of escitalopram in a large patient population. METHOD: A total of 4,228 escitalopram serum concentration measurements from 2,087 CYP2C19-genotyped patients 10-30 hours after drug intake were collected retrospectively from the drug monitoring database at Diakonhjemmet Hospital in Oslo...
January 12, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29322303/salt-tolerance-of-two-perennial-grass-brachypodium-sylvaticum-accessions
#20
Nir Sade, Maria Del Mar Rubio Wilhelmi, Xiaojuan Ke, Yariv Brotman, Matthew Wright, Imran Khan, Wagner De Souza, Elias Bassil, Christian M Tobias, Roger Thilmony, John P Vogel, Eduardo Blumwald
We studied the salt stress tolerance of two accessions isolated from different areas of the world (Norway and Tunisia) and characterized the mechanism(s) regulating salt stress in Brachypodium sylvaticum Osl1 and Ain1. Perennial grasses are widely grown in different parts of the world as an important feedstock for renewable energy. Their perennial nature that reduces management practices and use of energy and agrochemicals give these biomass crops advantages when dealing with modern agriculture challenges such as soil erosion, increase in salinized marginal lands and the runoff of nutrients...
January 10, 2018: Plant Molecular Biology
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