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Medical dermatology

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https://www.readbyqxmd.com/read/29036253/understanding-state-regulation-of-biosimilars-and-effect-on-prescribers
#1
Katerina Yale, Olabola Awosika, Monica Rengifo-Pardo, Alison Ehrlich
Biologics are a mainstay of treatment for many dermatologic conditions, however the high costs can be prohibitive for many patients. A growing market of biosimilar drugs is emerging with the hope of providing patients access to more affordable medications. While the FDA has created an abbreviated licensure pathway for these drugs, states are still in the process of creating regulations regarding their substitution for reference biologics. This article looks to raise awareness of the current federal regulations and the differences among state regulations regarding the use of biosimilars...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29035287/cardio-pulmonary-involvement-in-systemic-sclerosis-a-study-at-a-tertiary-care-center
#2
Geetakiran Arakkal, Sudha Rani Chintagunta, Vasavilatha Chandika, Sudha Vani Damarla, Srinivas Manchala, B Udaya Kumar
BACKGROUND: Systemic sclerosis is a multisystem disorder characterized by microangiopathy, dysregulation of the immune system and massive deposition of collagen in the connective tissue of the skin, blood vessels and various internal organs. Although the mortality from renal crises has dropped significantly due to the use of angiotensin-converting enzyme inhibitors, cardiac and pulmonary involvement accounts for significant morbidity and mortality. We studied 28 patients with systemic sclerosis at Gandhi Medical College and Hospital, Hyderabad, over a period of two years for cardiopulmonary involvement...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29035284/traction-alopecia-a-neglected-entity-in-2017
#3
REVIEW
Christiana Oyinlola Akingbola, Jui Vyas
Traction alopecia was first described in 1904 but is still a cause of scarring hair loss in young women worldwide. It is unique in being initially a reversible then an irreversible (scarring) form of alopecia. Linked to tightly-pulled hairstyles, it is seen across all races. The pattern of hair loss depends on the style creating it but most commonly affects the frontotemporal hairline. There are some new examination findings associated with traction alopecia, which are traction folliculitis, the fringe sign and hair casts (pseudonits) on dermatoscopy...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29029902/spectrum-of-orocutaneous-disease-associations-genodermatoses-and-inflammatory-conditions
#4
REVIEW
Elizabeth G Wilder, Jillian Frieder, Suraj Sulhan, Pablo Michel, Jeffrey D Cizenski, John M Wright, M Alan Menter
The oral cavity and cutaneous organ systems share a close embryologic origin. Therefore, there are numerous dermatologic conditions presenting with concomitant oral findings of which the dermatologist must be aware. The second article in this continuing medical education series reviews inflammatory orocutaneous conditions and a number of genodermatoses. It is essential for dermatologists to be familiar with oral cavity manifestations associated with dermatologic diseases for prompt diagnosis, management, and appropriate referral to stomatology and dentistry...
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29020800/an-approach-to-minimising-risk-of-adrenal-insufficiency-when-discontinuing-oral-glucocorticoids
#5
Mathew N Nicholas, Stephanie K Li, Marlene Dytoc
Oral glucocorticoids are commonly used across every field of medicine; however, discontinuing them in patients can be challenging. The risk of acute adrenal crises secondary to glucocorticoid withdrawal can be fatal and arises from chronic suppression of the adrenal glands. Identifying risk factors for adrenal suppression in dermatological patients, such as doses greater than 5 to 7.5 mg of prednisone equivalent, duration of glucocorticoid use greater than 3 weeks, certain medications, and comorbidities, can help risk-stratify patients...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29020799/is-there-a-role-for-5-ht3-receptor-antagonists-in-the-treatment-of-opioid-induced-pruritus
#6
Saima Rashid, Disha D Trivedi, Mudher Al-Shathir, Marie Moulton, Steven J Baumrucker
Pruritus is an unpleasant irritation symptom that can be related to various systemic and dermatological conditions. Although underreported, pruritus is a common adverse event noted after use of opioid pain medications. This article reviews the current understanding of the mechanism of opioid-induced pruritus (OIP) and various pharmacological therapies. 5-Hydroxytryptamine 3 (5-HT3) receptor antagonists are potentially effective for treating OIP and may be a valuable treatment option if further controlled studies are encouraging...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28991327/-delusional-parasitosis-intestinal-and-dermatological-clinical-cases
#7
Edith Pérez de Arce, Daniela Rosset, Mario Arcos, Douglas Castillo, Carlos Gil, Caroll Beltrán, Luis Carlos Gil
Illusory parasitosis, better known as delusional parasitosis, is a neuropsychiatric syndrome in which patients have the belief of suffering a parasitic disease, that can not be demonstrated after an exhaustive medical study. These patients are characterized by being polyconsultants in different medical specialties and, many of them, have antecedents of psychiatric disorders, some of them undiagnosed. Knowing the existence of the clinical picture, diagnosing early and empathizing with the patient, could give to clinician some clues for a timely and assertive psychiatric referral, and improve patient adherence to the proposed treatment...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28979873/paederus-dermatitis-a-case-series
#8
Sahana Srihari, Ashwini P Kombettu, Kanthraj G Rudrappa, Jayadev Betkerur
Vorderman (1901) was the first to record blisters caused by beetles in medical literature. Blister beetle dermatitis is a cutaneous condition caused by the toxins released by blister beetles. The vesicant chemical in the body fluids of these insects causes an acute irritant contact dermatitis characterized by erythematovesicular lesions associated with burning sensation on exposed parts of the body. The aim of this study was to investigate the morphological patterns of blister beetle dermatitis. We conducted a 1-year (January-December 2014) prospective study of the clinical presentation of Paederus dermatitis noticed in urban and semiurban areas close to paddy fields in the Cauvery Basin, Mysuru, Karnataka...
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28973128/screening-guidelines-for-thyroid-function-in-children-with-alopecia-areata
#9
Deepa Patel, Ping Li, Andrew J Bauer, Leslie Castelo-Soccio
Importance: The incidence of thyroid disease in children with alopecia areata (AA) has been widely studied with no consensus on whether a true association with AA exists. In addition, screening practices for thyroid dysfunction in children with AA vary widely among clinicians. Objective: To reduce health care costs, eliminate unnecessary testing, and standardize clinical practices, we sought to to characterize thyroid function in children with AA to establish guidelines for screening...
September 27, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28972437/a-challenging-and-rewarding-time-the-early-days-of-graduate-medical-education-in-dermatology
#10
Margaret Maria Cocks
Specialized residency training was still in its infancy in mid-20th century America. While specialty boards in various fields such as ophthalmology and otolaryngology had been established in the 1920s and 1930s, the details of training programs were still being fine-tuned and formal curricula were lacking. In dermatology, three prominent physicians including Harry L. Arnold Jr., J. Lamar Callaway and Walter B. Shelley trained during these experimental days of medical education. Each of them captured personal reflections of their own training experiences in brief memoirs published in scientific journals...
January 1, 2017: Journal of Medical Biography
https://www.readbyqxmd.com/read/28969253/patch-test-results-from-an-occupational-and-contact-dermatitis-clinic-in-a-tertiary-care-hospital-of-southern-india-a-retrospective-study
#11
Kumaravel Sadagopan, Deepa Kalappan, Nirmala Sivaprakasam, Vinoth
INTRODUCTION: Occupational contact dermatitis, accounting for 95% of cases of occupational dermatoses, is the most common occupational skin disease. AIM: To find out the various allergens in different occupational and environmental settings causing contact allergy, from our patients presented with contact dermatitis. MATERIALS AND METHODS: It was a retrospective study from the data in hospital outpatient register over one year period, which includes patients with age ranging from 11 years to 73 years...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28966518/therapeutic-efficacy-of-combination-therapy-using-oral-cyclosporine-with-a-dietary-supplement-pantogar%C3%A2-in-twenty-nail-dystrophy
#12
Su Jin Oh, Jeong Eun Kim, Joo Yeon Ko, Young Suck Ro
BACKGROUND: Twenty-nail dystrophy (TND) is an acquired idiopathic disease characterized by dull, thin, lusterless, and fragile nails with fissuring, small regular pits, and excessive longitudinal ridging. Although various treatment modalities have been performed in order to treat TND, the effects of these treatments are controversial. OBJECTIVE: To evaluate the effectiveness of oral cyclosporine in TND. METHODS: A total of 38 patients with TND were treated with combination therapy using oral cyclosporine with a pantothenic acid complex-based dietary supplement (Pantogar®; Merz Pharmaceuticals GmbH, Germany), whereas 44 patients were treated with the pantothenic acid complex-based dietary supplement alone...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28966507/thiopurine-s-methyltransferase-polymorphisms-in-korean-dermatologic-patients
#13
Minseok Lee, Jimyung Seo, Dongsik Bang, Do Young Kim
BACKGROUND: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. TPMT genotyping is widely used for screening of AZA-related toxicity during routine clinical practice in Korea. However, the data of TPMT genotypes and its AZA-related toxicity have not been studied in the field of dermatology. OBJECTIVE: The aim of this study was to evaluate the genetic basis of TPMT polymorphism in Korean dermatologic patients and subsequently to investigate the relationship between mutant TPMT and adverse responses to AZA treatment...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28964540/racial-and-ethnic-differences-in-health-care-utilization-for-childhood-eczema-an-analysis-of-the-2001-2013-medical-expenditure-panel-surveys
#14
Alexander H Fischer, Daniel B Shin, David J Margolis, Junko Takeshita
BACKGROUND: Eczema is a common chronic inflammatory disease of the skin. Studies suggest differences in disease prevalence and severity by race/ethnicity. Our knowledge of health care utilization for eczema among different racial/ethnic groups remains limited. OBJECTIVE: To evaluate health care utilization for childhood eczema among different racial/ethnic groups in the United States. METHODS: We performed a cohort study of non-Hispanic white (reference), non-Hispanic black, and Hispanic white individuals under the age of 18 years with caregiver-reported eczema (N = 2043) pooled from the 2-year longitudinal cohorts of the 2001-2013 Medical Expenditure Panel Surveys...
September 27, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28954580/analysis-of-live-interactive-teledermatologic-consultations-for-prisoners-in-korea-for-3-years
#15
Jung Eun Seol, So Hee Park, Hyojin Kim
Introduction Teledermatology has contributed to the enhanced accessibility of underserved populations. This study investigated the prevalence and clinical outcomes of dermatologic diseases in prisoners in Korea through live interactive teledermatology (LITD) Method The medical records of patients in a Busan prison, who interacted with a dermatologist using LITD from July 2013 to August 2016, were reviewed retrospectively. Results The mean age of the 406 patients enrolled in the study was 39.0 years and 91.4% were male...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28954107/langerhans-cell-histiocytosis-with-neurological-injuries-diagnosed-from-a-single-cutaneous-lesion
#16
Andréa Bauer Bannach, Maria Teresa Fernandes Castilho Garcia, Deusita Fernandes Gandia Soares, Antônio Luiz de Arruda Mattos, Tomás Zecchini Barrese, Marilda Aparecida Milanez Morgado de Abreu
Histiocytoses are rare diseases caused by the proliferation of histiocytes. The pathogenesis remains unknown and the highest incidence occurs in pediatric patients. The clinical presentations can be varied, in multiple organs and systems, and the skin lesions are not always present. Evolution is unpredictable and treatment depends on the extent and severity of the disease. It is described the case of a patient with various neurological symptoms, extensively investigated, who had its was diagnosed with histiocytosis from a single skin lesion...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28954099/psychosocial-impact-of-acne-and-postinflammatory-hyperpigmentation
#17
Katlein França, Jonette Keri
Background: Acne is one of the most common skin diseases. It has significant effect on self-image and negative impact on quality of life. Postinflammatory hyperpigmentation is an acquired hypermelanosis that occurs after a skin injury or cutaneous inflammation. It is common sequelae in acne patients. Objectives: This study aimed to investigate the psychosocial impact of acne and postinflammatory hyperpigmentation among patients treated in a dermatology outpatient clinic at the University of Miami Hospital...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28947467/prevalence-and-associated-factors-of-skin-diseases-in-aged-nursing-home-residents-a-multicentre-prevalence-study
#18
Elisabeth Hahnel, Ulrike Blume-Peytavi, Carina Trojahn, Gabor Dobos, Irina Jahnke, Vera Kanti, Claudia Richter, Andrea Lichterfeld-Kottner, Natalie Garcia Bartels, Jan Kottner
OBJECTIVES: The aim of this study was to measure the prevalence of skin diseases in aged nursing home residents and to explore possible associations with demographic and medical characteristics. DESIGN: Descriptive multicentre prevalence study. SETTING AND PARTICIPANTS: The study was conducted in a random sample of ten institutional long-term care facilities in the federal state of Berlin, Germany. In total, n=223 residents were included. RESULTS: In total, 60 dermatological diseases were diagnosed...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28947407/skin-diseases-of-the-male-external-genitalia-in-the-tanlangai-hospital-in-brazzaville-congo
#19
E S Bayonne Kombo, A Gathse, R B Soussa, A W S Odzebe
To determine the frequency of diseases responsible for skin lesions of the male external genitalia. This descriptive retrospective study examined the medical records of patients older than 14 years treated for genital symptoms as outpatients at the Dermatology Department of Talangaï Hospital in Brazzaville in 2009-2011. Patients' sociodemographic, medical history, clinical, and laboratory data were collected on a standardized individual form. The data were processed with Epi Info 3.5.4 software. The records revealed 76 dermatoses of the male external genitalia treated in the three-year study period...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28943834/cutaneous-lyme-borreliosis-guideline-of-the-german-dermatology-society
#20
Heidelore Hofmann, Volker Fingerle, Klaus-Peter Hunfeld, Hans-Iko Huppertz, Andreas Krause, Sebastian Rauer, Bernhard Ruf
This guideline of the German Dermatology Society primarily focuses on the diagnosis and treatment of cutaneous manifestations of Lyme borreliosis. It has received consensus from 22 German medical societies and 2 German patient organisations. It is the first part of an AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V.) interdisciplinary guideline: "Lyme Borreliosis - Diagnosis and Treatment, development stage S3". The guideline is directed at physicians in private practices and clinics who treat Lyme borreliosis...
2017: German Medical Science: GMS E-journal
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