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https://www.readbyqxmd.com/read/29160779/outcome-of-intravitreal-aflibercept-for-refractory-pigment-epithelial-detachment-with-or-without-subretinal-fluid-and-secondary-to-age-related-macular-degeneration
#1
Kiyoung Kim, Eung Suk Kim, Yonguk Kim, Ji Ho Yang, Seung-Young Yu, Hyung Woo Kwak
PURPOSE: To investigate the outcomes of intravitreal aflibercept in refractory pigment epithelial detachment (PED) with or without subretinal fluid (SRF) in patients with neovascular age-related macular degeneration. METHODS: A prospective, nonrandomized, interventional case series involved 40 patients with persistent vascularized PED previously treated with at least 3 injections of intravitreal bevacizumab or ranibizumab. Intravitreal aflibercept was administered as 3 initial loading doses every 4 weeks, followed by pro re nata retreatment every 8 weeks over 48 weeks...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29158071/frequency-of-and-factors-related-to-pro-re-nata-prn-medication-use-in-aged-care-services
#2
Jacquelina Stasinopoulos, J Simon Bell, Taliesin E Ryan-Atwood, Edwin C K Tan, Jenni Ilomäki, Tina Cooper, Leonie Robson, Janet K Sluggett
BACKGROUND: Little is known about the contribution of 'pro re nata' (PRN) medications to overall medication burden in residential aged care services (RACS). OBJECTIVES: To determine the frequency of, and factors associated with PRN medication administration in RACS. MEASUREMENTS: Details of all medications charted for regular or PRN use were extracted from medication charts for 383 residents of 6 Australian RACS. Records of medications administered over a 7 day period were also extracted...
November 7, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29156071/arthroscopic-repair-of-full-thickness-rotator-cuff-tears-in-active-patients-younger-than-40-years-2-to-5-year-clinical-outcomes
#3
Nata Parnes, Nicole R Bartoszewski, Michael J Defranco
This study characterized injury patterns and reported clinical outcomes of all-arthroscopic management of full-thickness rotator cuff tears among military patients younger than 40 years. A retrospective review was performed of prospective data for 42 patients younger than 40 years who underwent arthroscopic rotator cuff repair and, in some cases, concomitant labral repair. Preoperative and postoperative evaluations (minimum follow-up, 2 years; mean, 41 months; range, 24-66 months) included range of motion, visual analog scale (VAS) score, Subjective Shoulder Value (SSV), and American Shoulder and Elbow Surgeons (ASES) Shoulder Score...
November 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/29150027/tailored-resections-in-oral-and-oropharyngeal-cancer-using-narrow-band-imaging
#4
Giancarlo Tirelli, Marco Piovesana, Alberto Vito Marcuzzo, Annalisa Gatto, Matteo Biasotto, Rossana Bussani, Lorenzo Zandonà, Fabiola Giudici, Francesca Boscolo Nata
PURPOSE: In a previous pilot study we observed that intra-operative narrow-band imaging (NBI) helps achieve clear superficial resection margins. The aim of this study was to verify if the use of intra-operative NBI can help to obtain tailored resections and if it is influenced by the lesion site, aspects not investigated in our previous study. MATERIALS AND METHODS: The resection margins of 39 oral and 22 oropharyngeal squamous cell carcinomas were first set at 1...
November 10, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29130626/age-related-macular-degeneration-using-morphological-predictors-to-modify-current-treatment-protocols
#5
REVIEW
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'...
November 11, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29122301/the-use-of-prns-medications-with-hospitalized-older-adults
#6
Steven L Baumann, Nina Greif
The use of pro re nata (PRN) medications are a routine part of the treatment provided to most hospitalized older adults. The purpose of this article is to review the risks and benefits of using PRN medications in the acutely medically ill hospitalized older adult. After the discussion of a case study, recommendations are provided nurses and prescribers to reduce the risk of short and long term adverse consequences for the senior in the acute care hospital setting.
November 6, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29096573/drug-related-problems-and-changes-in-drug-utilization-after-medication-reviews-in-nursing-homes-in-oslo-norway
#7
Amura Francesca Fog, Gunnar Kvalvaag, Knut Engedal, Jørund Straand
OBJECTIVE: We describe the drug-related problems (DRPs) identified during medication reviews (MRs) and the changes in drug utilization after MRs at nursing homes in Oslo, Norway. We explored predictors for the observed changes. DESIGN: Observational before-after study. SETTING: Forty-one nursing homes. INTERVENTION: MRs performed by multidisciplinary teams during November 2011 to February 2014. SUBJECTS: In all, 2465 long-term care patients...
November 2, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/29094167/effects-of-aflibercept-for-neovascular-age-related-macular-degeneration-a-systematic-review-and-meta-analysis-of-observational-comparative-studies
#8
Yan Zhang, Catherine Chioreso, Marin L Schweizer, Michael D Abràmoff
Purposes: To compare the effects of aflibercept and other anti-vascular endothelial growth factor (anti-VEGF) medications on both functional and anatomical outcomes for treatment-naïve neovascular age-related macular degeneration (nAMD) in the real world. Methods: A systematic review and meta-analysis of observational comparative studies. Results: A total of 18 studies remained after literature selection and quality assessment of 1697 studies...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29090846/the-relation-study-efficacy-and-safety-of-ranibizumab-combined-with-laser-photocoagulation-treatment-versus-laser-monotherapy-in-npdr-and-pdr-patients-with-diabetic-macular-oedema
#9
Gabriele E Lang, Sandra Liakopoulos, Jessica Vögeler, Claudia Weiß, Georg Spital, Maria-Andreea Gamulescu, Chris Lohmann, Peter Wiedemann
PURPOSE: To assess efficacy and safety of intravitreal ranibizumab 0.5 mg plus laser (COMBI) versus laser monotherapy (LASER) in patients with visual impairment due to diabetic macular oedema (DME) in either nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) and to analyse the relevance of inner versus outer retinal thickness. METHODS: In this double-masked, multicentre phase IIIb study, patients (N = 128) were randomized (2:1) to receive COMBI (n = 85) versus LASER (n = 43)...
November 1, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29080915/detailed-analysis-of-retinal-morphology-in-patients-with-diabetic-macular-edema-dme-randomized-to-ranibizumab-or-triamcinolone-treatment
#10
Sonja G Karst, Jan Lammer, Christoph Mitsch, Manuela Schober, Janhvi Mehta, Christoph Scholda, Michael Kundi, Katharina Kriechbaum, Ursula Schmidt-Erfurth
PURPOSE: Our purpose was to compare the impact in diabetic macula edema (DME) of two intravitreal drugs (0.5 mg ranibizumab vs. 8 mg triamcinolone) on changes in retinal morphology in spectral-domain optical coherence tomography (SD OCT) images, color fundus photography (CF) and fluorescein angiography (FA) images during a 1-year follow-up. METHODS: Post hoc analysis was conducted of morphologic characteristics in OCT, FA and CF images of eyes with a center involving DME that were included in a prospective double-masked randomized trial...
October 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29077191/pegaptanib-choroidal-neovascularization-in-patients-with-age-related-macular-degeneration-and-previous-arterial-thromboembolic-events
#11
Maurizio Battaglia Parodi, Emanuele Di Bartolo, Claudia Brue, Ezio Cappello, Claudio Furino, Sebastiano Giuffrida, Manuela Imparato, Michele Reibaldi
PURPOSE: To evaluate the efficacy and the rate of side effects of the pegylated aptamer pegaptanib in the treatment of patients with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and a history of previous arterial thromboembolic events (ATEs). METHODS: Twenty-three eyes of 23 patients with subfoveal CNV due to AMD and cerebrovascular accidents (n = 12) and myocardial infarction (n = 11) in the previous 6 months received intravitreal pegaptanib 0...
October 25, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29077188/aflibercept-in-the-treatment-of-diabetic-macular-edema-a-review-and-consensus-paper
#12
Teresio Avitabile, Claudio Azzolini, Francesco Bandello, Francesco Boscia, Sandro De Falco, Diego Fornasari, Paolo Lanzetta, Leonardo Mastropasqua, Edoardo Midena, Federico Ricci, Giovanni Staurenghi, Monica Varano
PURPOSE: To reach a consensus, among experts, on the role of aflibercept in diabetic macular edema (DME) through literature review. METHODS: Two round tables, involving 12 Italian experts, were organized: in the first one, 6 pharmacologic and clinical questions were selected and analyzed by a systematic literature review, using a population, intervention, control, and outcomes framework; in the second one, the nominal group technique was used to discuss relevant evidence related to each question...
October 14, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29063703/analysis-of-retinal-layer-thickness-in-diabetic-macular-oedema-treated-with-ranibizumab-or-triamcinolone
#13
Sonja G Prager, Jan Lammer, Christoph Mitsch, Julia Hafner, Berthold Pemp, Christoph Scholda, Michael Kundi, Ursula Schmidt-Erfurth, Katharina Kriechbaum
PURPOSE: To evaluate detailed changes in retinal layer thickness in spectral-domain optical coherence tomography (SD-OCT) images during a 1-year follow-up of patients treated for diabetic macula oedema (DME). METHODS: Post hoc analysis of retinal layer thickness changes applying the automated layer segmentation of SD-OCT images in eyes with DME that were randomly assigned to receive pro re nata (PRN) treatment with either 0.5 mg ranibizumab or 8 mg triamcinolone...
October 24, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29057640/the-armour-study-anti-vegf-in-neovascular-amd-our-understanding-in-a-real-world-indian-setting
#14
Nimesh Jain, Naresh Kumar Yadav, Chaitra Jayadev, Priya Srinivasan, Ashwin Mohan, Bhujang K Shetty
PURPOSE: The aim of our study was to share our experience with anti‒vascular endothelial growth factor (anti-VEGF) injections in the treatment of neovascular age-related macular degeneration (nAMD) in a real-world setting. DESIGN: A retrospective, observational study. METHODS: Patients of Indian origin with nAMD receiving anti-VEGF with a minimum follow-up of 12 months were enrolled in this study. In group 1, patients were treated on a pro re nata (PRN) basis; in group 2, patients received a loading dose (3 injections) and were then treated on a PRN basis...
October 23, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29055730/-management-of-wet-amd-in-france-in-2015
#15
J Zerbib, A Bourhis, P L Cornut, F De Bats, V Gualino, J Halfon, H Massé, M Srour, M Streho, S Tick, B Wolff, N San Nicolas
PURPOSE AND CONTEXT: Intravitreal administration of anti-VEGF agents, available in France since 2007, allows stabilization and improvement in visual acuity in wet age-related macular degeneration (AMD). In the past few years, the management of this disease has evolved in terms of both diagnostic methods and treatment schedules, which have been adapted to the pathophysiology of AMD. The goal of this survey, performed in a representative sample of French ophthalmologists, was to describe the evolution of medical practices one year after a similar survey (Massé et al...
November 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29048767/risk-assessment-and-subsequent-nursing-interventions-in-a-forensic-mental-health-inpatient-setting-associations-and-impact-on-aggressive-behaviour
#16
Tessa Maguire, Michael Daffern, Steven J Bowe, Brian McKenna
AIM AND OBJECTIVES: To examine associations between risk of aggression and nursing interventions designed to prevent aggression. BACKGROUND: There is scarce empirical research exploring the nature and effectiveness of interventions designed to prevent inpatient aggression. Some strategies may be effective when patients are escalating, whereas others may be effective when aggression is imminent. Research examining level of risk for aggression and selection and effectiveness of interventions and impact on aggression is necessary...
October 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29046647/east-london-modified-broset-as-decision-making-tool-to-predict-seclusion-in-psychiatric-intensive-care-units
#17
Felice Loi, Karl Marlowe
Seclusion is a last resort intervention for management of aggressive behavior in psychiatric settings. There is no current objective and practical decision-making instrument for seclusion use on psychiatric wards. Our aim was to test the predictive and discriminatory characteristics of the East London Modified-Broset (ELMB), to delineate its decision-making profile for seclusion of adult psychiatric patients, and second to benchmark it against the psychometric properties of the Broset Violence Checklist (BVC)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29042251/effects-of-heparan-sulfate-proteoglycan-syndecan-4-on-the-insulin-secretory-response-in-a-mouse-pancreatic-%C3%AE-cell-line-min6
#18
Iwao Takahashi, Shuhei Yamada, Koji Nata
Heparan sulfate proteoglycans (HSPGs) comprise a core protein to which extracellular glycosaminoglycan chains are attached. Syndecan-4, one of the major HS-containing core proteins, is distributed on the cell surface, where they interact with various protein ligands and regulate a wide range of biological activities. Here, we propose that the core protein of HSPGs is involved in the insulin secretory response. To investigate the participation of HSPGs in the insulin-secretion mechanism, MIN6 cells, a mouse pancreatic β-cell line, were subcloned...
October 16, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29016658/probing-the-interaction-between-nata-and-the-ribosome-for-co-translational-protein-acetylation
#19
Robert S Magin, Sunbin Deng, Haibo Zhang, Barry Cooperman, Ronen Marmorstein
N-terminal acetylation is among the most abundant protein modifications in eukaryotic cells. Over the last decade, significant progress has been made in elucidating the function of N-terminal acetylation for a number of diverse systems, involved in a wide variety of biological processes. The enzymes responsible for the modification are the N-terminal acetyltransferases (NATs). The NATs are a highly conserved group of enzymes in eukaryotes, which are responsible for acetylating over 80% of the soluble proteome in human cells...
2017: PloS One
https://www.readbyqxmd.com/read/28983556/efficacy-and-safety-of-ranibizumab-with-or-without-verteporfin-photodynamic-therapy-for-polypoidal-choroidal-vasculopathy-a-randomized-clinical-trial
#20
Adrian Koh, Timothy Y Y Lai, Kanji Takahashi, Tien Y Wong, Lee-Jen Chen, Paisan Ruamviboonsuk, Colin S Tan, Chrystel Feller, Philippe Margaron, Tock H Lim, Won Ki Lee
Importance: Polypoidal choroidal vasculopathy (PCV) is a common subtype of exudative age-related macular degeneration among Asian individuals. To our knowledge, there are no large randomized clinical trials to evaluate intravitreal ranibizumab, with and without verteporfin photodynamic therapy (vPDT), for the treatment of PCV. Objective: To compare the efficacy and safety of combination therapy of ranibizumab and vPDT with ranibizumab monotherapy in PCV. Design, Setting, and Participants: A double-masked, multicenter randomized clinical trial of 322 Asian participants with symptomatic macular PCV confirmed by the Central Reading Center using indocyanine green angiography was conducted between August 7, 2013, and March 2, 2017...
November 1, 2017: JAMA Ophthalmology
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