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https://www.readbyqxmd.com/read/29772042/subfoveal-choroidal-thickness-as-a-potential-predictor-of-clinical-response-to-stereotactic-radiotherapy-for-neovascular-age-related-macular-degeneration
#1
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
BACKGROUND AND OBJECTIVE: Stereotactic radiotherapy (SRT) is a new adjuvant treatment modality that has been shown to reduce the need for repetitive intravitreal injections (IVIs) in patients with neovascular age-related macular degeneration (nAMD). The authors aimed to determine baseline predictors of clinical response to SRT. PATIENTS AND METHODS: This was a retrospective, observational case series of patients with nAMD who underwent SRT and subsequently had at least 12 months of complete follow-up...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29754825/structure-of-human-nata-and-its-regulation-by-the-huntingtin-interacting-protein-hypk
#2
Leah Gottlieb, Ronen Marmorstein
Co-translational N-terminal protein acetylation regulates many protein functions including degradation, folding, interprotein interactions, and targeting. Human NatA (hNatA), one of six conserved metazoan N-terminal acetyltransferases, contains Naa10 catalytic and Naa15 auxiliary subunits, and associates with the intrinsically disordered Huntingtin yeast two-hybrid protein K (HYPK). We report on the crystal structures of hNatA and hNatA/HYPK, and associated biochemical and enzymatic analyses. We demonstrate that hNatA contains unique features: a stabilizing inositol hexaphosphate (IP6 ) molecule and a metazoan-specific Naa15 domain that mediates high-affinity HYPK binding...
April 23, 2018: Structure
https://www.readbyqxmd.com/read/29752835/documentation-of-psychotropic-prn-medication-administration-an-evaluation-of-electronic-health-records-compared-with-paper-charts-and-verbal-reports
#3
Krystle Martin, Elke Ham, Zoe Hilton
AIMS AND OBJECTIVES: To describe the documentation of pro re nata (PRN) medication for anxiety, and to compare documentation at two hospitals providing similar psychiatric services, one that used paper charts and another that used an electronic health record (EHR). We also assessed congruence between nursing documentation and verbal reports from staff about the PRN administration process. BACKGROUND: The ability to accurately document patients' symptoms and the care given is considered a core competency of the nursing profession (Wilkinson, 2007); however, researchers have found poor concordance between nursing notes and verbal reports or observations of events (e...
May 12, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29748569/a-novel-naa10-variant-with-impaired-acetyltransferase-activity-causes-developmental-delay-intellectual-disability-and-hypertrophic-cardiomyopathy
#4
Svein Isungset Støve, Marina Blenski, Asbjørg Stray-Pedersen, Klaas J Wierenga, Shalini N Jhangiani, Zeynep Coban Akdemir, David Crawford, Nina McTiernan, Line M Myklebust, Gabriela Purcarin, Rene McNall-Knapp, Alexandrea Wadley, John W Belmont, Jeffrey J Kim, James R Lupski, Thomas Arnesen
The NAA10-NAA15 complex (NatA) is an N-terminal acetyltransferase that catalyzes N-terminal acetylation of ~40% of all human proteins. N-terminal acetylation has several different roles in the cell, including altering protein stability and degradation, protein localization and protein-protein interactions. In recent years several X-linked NAA10 variants have been associated with genetic disorders. We have identified a previously undescribed NAA10 c.215T>C p.(Ile72Thr) variant in three boys from two unrelated families with a milder phenotypic spectrum in comparison to most of the previously described patients with NAA10 variants...
May 10, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29737196/changing-characteristics-of-a-psychiatric-emergency-care-centre-an-eight-year-follow-up-study
#5
Joanne Seymour, Tristan Chapman, Vladan Starcevic, Kirupamani Viswasam, Vlasios Brakoulias
OBJECTIVE: The objective of this study was to report changes in characteristics of admissions to an established Psychiatric Emergency Care Centre (PECC) eight years after its opening. METHOD: Key clinical characteristics of admissions to the PECC were documented for 327 patients in 2015 and compared with the 477 patients in 2007, which is when the centre first opened. The characteristics of admission were evaluated using an audit of medical records from June to December in both 2007 and 2015...
May 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29734180/influence-of-the-vitreoretinal-interface-on-the-treatment-with-anti-vegf-for-exudative-age-related-macular-degeneration
#6
Pedro Gil, João Gil, Nuno Oliveira, Inês Laíns, Eduardo Nery Rossi Camilo, Cristina Fonseca, Miguel Raimundo, Maria da Luz Cachulo, Rufino Silva
PURPOSE: To investigate the influence of the vitreoretinal interface on the outcomes of different ranibizumab regimens for exudative age-related macular degeneration. METHODS: We conducted a retrospective subanalysis of 2 prospective clinical trials. Patients were treated with ranibizumab for 12 months according to 3 different regimens: pro-re-nata (PRN), treat and extend (T&E), and monthly. Vitreoretinal interface was assessed for absence (group ON) or presence (group OFF) of posterior vitreous detachment (PVD)...
May 7, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29733040/knowledge-attitude-and-perception-of-risk-management-of-steam-boilers-among-workers-in-palm-oil-mills
#7
Faten Noor Suhaida Shawal, Ng Yee Guan, Dayana Hazwani Mohd Suadi Nata, Vivien How, Shamsul Bahri Mohd Tamrin
BACKGROUND: People who work with the steam boilers in palm oil mills are vulnerable to accidents, notably to explosions, whenever failures of any kind occur during their operation. OBJECTIVE: This cross-sectional study was conducted in palm oil mills to determine the knowledge, attitude, and perception (KAP) concerning the risk management of steam boilers among workers in palm oil mills. METHODS: A total of 50 workers who were working with steam boilers and/or involved in managing the operation of steam boilers with at least three years of working experience in the palm oil industry were purposively sampled...
May 3, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29695927/non-hispanic-black-white-disparities-in-pain-and-pain-management-among-newly-admitted-nursing-home-residents-with-cancer
#8
Deborah S Mack, Jacob N Hunnicutt, Bill M Jesdale, Kate L Lapane
Background: Racial disparities in pain management persist across health care settings and likely extend into nursing homes. No recent studies have evaluated racial disparities in pain management among residents with cancer in nursing homes at time of admission. Methods: Using a cross-sectional study design, we compared reported pain and pain management between non-Hispanic White and non-Hispanic Black newly admitted nursing home residents with cancer (n=342,920) using the de-identified Minimum Data Set version 3...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29690218/a-review-of-the-genus-eugoa-walker-lepidoptera-erebidae-arctiinae-lithosiini-in-cambodia-with-the-description-of-a-new-species
#9
Ulziijargal Bayarsaikhan, Karol Bucsek, Yang-Seop Bae
Eugoa Walker (Arctiinae, Lithosiini) from Cambodia is reviewed. The genus counts with 20 species in this country, including Eugoa arguta Bayarsaikhan Bae, n. sp., and three newly recorded species, E. vasta van Eecke, 1920, rest. comb., E. formosicola (Matsumura, 1927), n. st. and E. kuznetzovi Dubatolov Bucsek, 2016. Besides our revalidation of Eugoa bipunctata formosicola as a valid species, it was also discovered to have a synonym: E. cesaneki Bucsek, 2008 n. syn. Moreover, females of E. lucea Bucsek, 2012, E...
April 5, 2018: Zootaxa
https://www.readbyqxmd.com/read/29689025/combination-therapy-of-intravitreal-ranibizumab-and-subthreshold-micropulse-photocoagulation-for-macular-edema-secondary-to-branch-retinal-vein-occlusion-6-month-result
#10
Hiroko Terashima, Hiruma Hasebe, Fumiki Okamoto, Naoki Matsuoka, Yayoi Sato, Takeo Fukuchi
PURPOSE: To determine the efficacy of the combination therapy of intravitreal ranibizumab (IVR) and 577-nm yellow laser subthreshold micropulse laser photocoagulation (SMLP) for macular edema secondary to branch retinal vein occlusion cystoid macular edema. METHODS: Retrospective, consecutive, case-control study. Forty-six eyes of 46 patients with treatment-naive branch retinal vein occlusion cystoid macular edema were enrolled. The IVR + SMLP group consisted of 22 patients who had undergone both SMLP and IVR...
April 23, 2018: Retina
https://www.readbyqxmd.com/read/29661304/preparation-of-nano-sized-particles-from-bacterial-cellulose-using-ultrasonication-and-their-characterization
#11
Hairul Abral, Vincent Lawrensius, Dian Handayani, Eni Sugiarti
As more applications for nano-sized natural particles are discovered, simple, environmentally friendly ways to produce these particles become more important. This work prepares and characterizes nano-size bacterial cellulose particles using ultrasonication. Pellicle from nata de coco containing nanofibers was broken up in an electrical blender, then sonicated using an ultrasonic probe at 20 kHz and 3 W/mL for 30, 60 and 90 min. Transmission electron microscope observations indicate the particles become nano-sized after 60 min ultrasound...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29656860/truncating-variants-in-naa15-are-associated-with-variable-levels-of-intellectual-disability-autism-spectrum-disorder-and-congenital-anomalies
#12
Hanyin Cheng, Avinash V Dharmadhikari, Sylvia Varland, Ning Ma, Deepti Domingo, Robert Kleyner, Alan F Rope, Margaret Yoon, Asbjørg Stray-Pedersen, Jennifer E Posey, Sarah R Crews, Mohammad K Eldomery, Zeynep Coban Akdemir, Andrea M Lewis, Vernon R Sutton, Jill A Rosenfeld, Erin Conboy, Katherine Agre, Fan Xia, Magdalena Walkiewicz, Mauro Longoni, Frances A High, Marjon A van Slegtenhorst, Grazia M S Mancini, Candice R Finnila, Arie van Haeringen, Nicolette den Hollander, Claudia Ruivenkamp, Sakkubai Naidu, Sonal Mahida, Elizabeth E Palmer, Lucinda Murray, Derek Lim, Parul Jayakar, Michael J Parker, Stefania Giusto, Emanuela Stracuzzi, Corrado Romano, Jennifer S Beighley, Raphael A Bernier, Sébastien Küry, Mathilde Nizon, Mark A Corbett, Marie Shaw, Alison Gardner, Christopher Barnett, Ruth Armstrong, Karin S Kassahn, Anke Van Dijck, Geert Vandeweyer, Tjitske Kleefstra, Jolanda Schieving, Marjolijn J Jongmans, Bert B A de Vries, Rolph Pfundt, Bronwyn Kerr, Samantha K Rojas, Kym M Boycott, Richard Person, Rebecca Willaert, Evan E Eichler, R Frank Kooy, Yaping Yang, Joseph C Wu, James R Lupski, Thomas Arnesen, Gregory M Cooper, Wendy K Chung, Jozef Gecz, Holly A F Stessman, Linyan Meng, Gholson J Lyon
N-alpha-acetylation is a common co-translational protein modification that is essential for normal cell function in humans. We previously identified the genetic basis of an X-linked infantile lethal Mendelian disorder involving a c.109T>C (p.Ser37Pro) missense variant in NAA10, which encodes the catalytic subunit of the N-terminal acetyltransferase A (NatA) complex. The auxiliary subunit of the NatA complex, NAA15, is the dimeric binding partner for NAA10. Through a genotype-first approach with whole-exome or genome sequencing (WES/WGS) and targeted sequencing analysis, we identified and phenotypically characterized 38 individuals from 33 unrelated families with 25 different de novo or inherited, dominantly acting likely gene disrupting (LGD) variants in NAA15...
April 9, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29622068/-renal-venous-thrombosis-as-a-complication-of-nephrotic-syndrome
#13
Nata Kermanian, Kaj Aage Hansen
Venous thromboembolism is a very common complication of nephrotic syndrome (NS). This case report concerns a 19-year-old male, who had known NS and was admitted two times in a short period, first presenting with recurrent symptoms of NS and later with an acute abdomen, which was diagnosed as renal venous thrombosis (RVT) and pulmonary thromboembolism. The patient was treated with prednisolone and therapeutic doses of dalteparin and warfarin. Venous thrombosis, particularly RVT and pulmonary thromboembolism, should be considered in patients with NS...
April 2, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29619858/influence-of-serous-retinal-detachment-on-the-outcome-of-ranibizumab-treatment-in-diabetic-macular-edema
#14
Nimet Yesim Ercalik, Serhat Imamoglu, Esra Turkseven Kumral, Nursal Melda Yenerel, Handan Bardak, Yavuz Bardak
PURPOSE: The purpose of this study was to evaluate the influence of serous retinal detachment (SRD) on the outcome of intravitreal ranibizumab (IVR) therapy in diabetic macular edema (DME). MATERIALS AND METHODS: Fifty-one eyes with cystoid macular edema (CME) and SRD (study group) and 57 eyes with only CME (control group) that received pro re nata (PRN) IVR injections during a 6-month period were retrospectively evaluated. The outcome measures included changes in the central macular thickness (CMT) and best corrected visual acuity (BCVA) and injection numbers...
April 5, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29614013/selection-of-potential-therapeutic-bacteriophages-that-lyse-a-ctx-m-15-extended-spectrum-%C3%AE-lactamase-producing-salmonella-enterica-serovar-typhi-strain-from-the-democratic-republic-of-the-congo
#15
Elene Kakabadze, Khatuna Makalatia, Nino Grdzelishvili, Nata Bakuradze, Marina Goderdzishvili, Ia Kusradze, Marie-France Phoba, Octavie Lunguya, Cédric Lood, Rob Lavigne, Jan Jacobs, Stijn Deborggraeve, Tessa De Block, Sandra Van Puyvelde, David Lee, Aidan Coffey, Anahit Sedrakyan, Patrick Soentjens, Daniel De Vos, Jean-Paul Pirnay, Nina Chanishvili
Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S . Typhi, and Salmonella in general.
April 3, 2018: Viruses
https://www.readbyqxmd.com/read/29581904/nightmare-and-abnormal-dreams-rare-side-effects-of-metformin
#16
Theo Audi Yanto, Ian Huang, Felicia Nathania Kosasih, Nata Pratama Hardjo Lugito
Background: Metformin is widely known as an antidiabetic agent which has significant gastrointestinal side effects, but nightmares and abnormal dreams as its adverse reactions are not well reported. Case Presentation: Herein we present a case of 56-year-old male patient with no known history of recurrent nightmares and sleep disorder, experiencing nightmare and abnormal dreams directly after consumption of 750 mg extended release metformin. He reported his dream as an unpleasant experience which awakened him at night with negative feelings...
2018: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29575941/treatment-outcomes-of-conventional-or-high-dose-ranibizumab-for-vascularized-pigment-epithelial-detachment-based-on-lesion-subtypes
#17
Clement K Chan, David Sarraf, Prema Abraham
INTRODUCTION: A post hoc study was conducted to compare visual and anatomic outcomes of vascularized serous pigment epithelial detachment (Group 1) with fibrovascular pigment epithelial detachment (Group 2) due to age-related macular degeneration treated with either 0.5 or 2.0 mg ranibizumab injections. METHODS: A prospective, randomized trial was performed with the following regimens for 12 months: (1) 0.5 mg monthly, (2) 0.5 mg monthly for 4 months followed by pro re nata injections, (3) 2...
February 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29566387/spectral-domain-optical-coherence-tomography-driven-treat-and-extend-and-pro-re-nata-regimen-in-patients-with-macular-oedema-due-to-retinal-vein-occlusion-24-month-evaluation-and-outcome-predictors
#18
Maria-Magdalena Guichard, Anton R Xavier, Cengiz Türksever, Christian Pruente, Katja Hatz
PURPOSE: To analyse the efficacy and outcome predictors of ranibizumab using a spectral-domain optical coherence tomography (SD-OCT)-driven treat-and-extend regimen (TER) versus SD-OCT-driven pro re nata regimen (PRN) in patients with cystoid macular oedema (CME) due to branch or central retinal vein occlusion (BRVO, CRVO). METHODS: Retrospective, consecutive case series. Evaluation included best corrected visual acuity (BCVA), morphological parameters on SD-OCT, and treatment frequency...
March 22, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29563771/age-sex-and-type-of-medication-predict-the-effect-of-anti-vegf-treatment-on-central-retinal-thickness-in-wet-age-related-macular-degeneration
#19
Toke Bek, Sidsel Ehlers Klug
Purpose: Randomized clinical trials studying the effects of VEGF inhibition on wet age-related macular degeneration (wAMD) are designed so that the effects of individually varying risk factors on the treatment response are eliminated. The influence of these risk factors can be studied in large data sets from real-life experience. Patients and methods: All 2,255 patients diagnosed with wAMD requiring anti-VEGF treatment in at least one eye over more than 9 years in a defined Danish population with 0...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29558889/naa10-dysfunction-with-normal-nata-complex-activity-in-a-girl-with-non-syndromic-id-and-a-de-novo-naa10-p-v111g-variant-a-case-report
#20
Nina McTiernan, Svein Isungset Støve, Ingvild Aukrust, Marita Torrisen Mårli, Line M Myklebust, Gunnar Houge, Thomas Arnesen
BACKGROUND: The NAA10-NAA15 (NatA) protein complex is an N-terminal acetyltransferase responsible for acetylating ~ 40% of eukaryotic proteins. In recent years, NAA10 variants have been found in patients with an X-linked developmental disorder called Ogden syndrome in its most severe form and, in other familial or de novo cases, with variable degrees of syndromic intellectual disability (ID) affecting both sexes. CASE PRESENTATION: Here we report and functionally characterize a novel and de novo NAA10 (NM_003491...
March 20, 2018: BMC Medical Genetics
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