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https://www.readbyqxmd.com/read/29325541/interprofessional-collaboration-in-nursing-homes-interprof-development-and-piloting-of-measures-to-improve-interprofessional-collaboration-and-communication-a-qualitative-multicentre-study
#1
Christiane A Müller, Nina Fleischmann, Christoph Cavazzini, Susanne Heim, Svenja Seide, Christina Geister, Britta Tetzlaff, Andreas Hoell, Jochen Werle, Siegfried Weyerer, Martin Scherer, Eva Hummers
BACKGROUND: Given both the increase of nursing home residents forecast and challenges of current interprofessional interactions, we developed and tested measures to improve collaboration and communication between nurses and general practitioners (GPs) in this setting. Our multicentre study has been funded by the German Federal Ministry of Education and Research (FK 01GY1124). METHODS: The measures were developed iteratively in a continuous process, which is the focus of this article...
January 11, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29318167/a-comparison-of-cervical-spine-motion-after-immobilization-with-a-traditional-spine-board-and-full-body-vacuum-mattress-splint
#2
Brian E Etier, Grant E Norte, Megan M Gleason, Dustin L Richter, Kelli F Pugh, Keith B Thomson, Lindsay V Slater, Joe M Hart, Stephen F Brockmeier, David R Diduch
Background: The National Athletic Trainers' Association (NATA) advocates for cervical spine immobilization on a rigid board or vacuum splint and for removal of athletic equipment before transfer to an emergency medical facility. Purpose: To (1) compare triplanar cervical spine motion using motion capture between a traditional rigid spine board and a full-body vacuum splint in equipped and unequipped athletes, (2) assess cervical spine motion during the removal of a football helmet and shoulder pads, and (3) evaluate the effect of body mass on cervical spine motion...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29317400/two-year-outcomes-of-intravitreal-ziv-aflibercept
#3
Ahmad M Mansour, Mohammed Ashraf, Abdulrazzak Charbaji, Muhammad H Younis, Ahmed A Souka, Avantika Dogra, Hana A Mansour, Jay Chhablani
AIM: To assess the two-year outcome of intravitreal ziv-aflibercept (IVZ) in eyes with macular diseases. METHODS: Consecutive subjects with various macular diseases that received six or more of 0.05 mL IVZ (1.25 mg) injections with at least 1 year follow-up were included. Outcome measures were best-corrected visual acuity (BCVA) (logarithm of the minimum angle of resolution) and central macular thickness (CMT) on spectral domain optical coherence tomography...
January 9, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29316015/tracking-the-effects-of-dyslexia-in-reading-and-spelling-development-a-longitudinal-study-of-greek-readers
#4
Vassiliki Diamanti, Nata Goulandris, Morag Stuart, Ruth Campbell, Athanassios Protopapas
In this study, we followed Greek children with and without dyslexia for 18 months, assessing them twice on a battery of phonological, reading, and spelling tasks, aiming to document the relative progress achieved and to uncover any specific effects of dyslexia in the development of reading and spelling beyond the longitudinal associations among variables that are observed in typical readers. A wide-ranging match was achieved between the dyslexic group and the younger reading-matched comparison group, enabling longitudinal comparisons on essentially identical initial performance profiles...
January 5, 2018: Dyslexia: the Journal of the British Dyslexia Association
https://www.readbyqxmd.com/read/29305321/factors-associated-with-symptom-relief-in-end-of-life-care-in-residential-care-homes-a-national-register-based-study
#5
Sofia Andersson, Kristofer Årestedt, Olav Lindqvist, Carl-Johan Fürst, Margareta Brännström
BACKGROUND: Residential care homes (RCHs) are a common place of death. Previous studies have reported a high prevalence of symptoms such as pain and shortness of breath among residents in the last week of life. AIM: To explore the presence of symptoms and symptom relief, and identify factors associated with symptom relief of pain, nausea, anxiety, and shortness of breath among RCH residents in end-of-life care. METHOD: The data consisted of all expected deaths at RCHs registered in the Swedish Register of Palliative Care (n=22 855)...
January 2, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29304262/prn-ranibizumab-in-the-treatment-of-choroidal-neovascularization-secondary-to-ocular-histoplasmosis
#6
Edward H Wood, Ryan J Whitted, Thomas W Stone, Ricky D Isernhagen, William J Wood, Diana M Holcomb, John W Kitchens
BACKGROUND AND OBJECTIVE: Ranibizumab (Lucentis; Genentech, South San Francisco, CA) is used off-label for the treatment of choroidal neovascularization secondary to ocular histoplasmosis syndrome (OHS). This study prospectively evaluates the safety and efficacy of two treatment paradigms utilizing ranibizumab 0.5 mg: one or three initial injections followed by monthly visits with PRN treatment through Month 12. PATIENTS AND METHODS: In this prospective, open-label study, 21 subjects were evaluated monthly and retreated during the pro re nata treatment phase if specific criteria were met, including loss of vision, increase in subretinal fluid, or hemorrhage...
January 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29278810/asthma-prevalence-and-school-related-hazardous-air-pollutants-in-the-us-m%C3%A3-xico-border-area
#7
Genny Carrillo, Maria J Perez Patron, Natalie Johnson, Yan Zhong, Rose Lucio, Xiaohui Xu
BACKGROUND: Asthma is the most common chronic disease in children and has been linked to high levels of ambient air pollution and certain hazardous air pollutants (HAPs). Outdoor pollutants such as benzene, released by car emissions, and organic chemicals found in diesel exhaust, as well as particles and irritant gases, including nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3), contribute to an increased prevalence of respiratory diseases such as asthma. OBJECTIVES: The objectives of this study were to: 1) conduct a screening survey to identify high risk for asthma among school-age children in Hidalgo County, and, 2) study the potential health impact of school-related exposure to HAPs pertaining to asthma risk...
December 23, 2017: Environmental Research
https://www.readbyqxmd.com/read/29247799/identification-of-an-alternatively-spliced-nuclear-isoform-of-human-n-terminal-acetyltransferase-naa30
#8
Sylvia Varland, Line M Myklebust, Siri Øfsthus Goksøyr, Nina Glomnes, Janniche Torsvik, Jan Erik Varhaug, Thomas Arnesen
N-terminal acetylation is a highly abundant and important protein modification in eukaryotes catalyzed by N-terminal acetyltransferases (NATs). In humans, six different NATs have been identified (NatA-NatF), each composed of individual subunits and acetylating a distinct set of substrates. Along with most NATs, NatC acts co-translationally at the ribosome. The NatC complex consists of the catalytic subunit Naa30 and the auxiliary subunits Naa35 and Naa38, and can potentially Nt-acetylate cytoplasmic proteins when the initiator methionine is followed by a bulky hydrophobic/amphipathic residue at position 2...
December 13, 2017: Gene
https://www.readbyqxmd.com/read/29240306/diabetic-macular-oedema-treated-with-intravitreal-anti-vascular-endothelial-growth-factor-2-4%C3%A2-years-follow-up-of-visual-acuity-and-retinal-thickness-in-566-patients-following-danish-national-guidelines
#9
Delila Hodzic-Hadzibegovic, Birgit Agnes Sander, Tine Juul Monberg, Michael Larsen, Henrik Lund-Andersen
PURPOSE: To investigate long-term functional and anatomical outcomes, discontinuation patterns, drug switching and rates of nonimprovement in patients treated with ranibizumab pro re nata (PRN) regimen for diabetic macular oedema (DME) according to the Danish national guidelines. METHODS: Retrospective cohort study of 566 eyes in 566 patients with centre-involved DME who started intravitreal treatment with ranibizumab between January 2011 and December 2013 in the Greater Copenhagen region...
December 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29232334/intravitreal-ziv-aflibercept-for-neovascular-age-related-macular-degeneration-52-week-results
#10
João R de Oliveira Dias, Gabriel Costa de Andrade, Vinicius F Kniggendorf, Eduardo A Novais, Vítor K L Takahashi, André Maia, Carsten Meyer, Sung E S Watanabe, Michel E Farah, Eduardo B Rodrigues
PURPOSE: To evaluate the 52-week safety and efficacy of intravitreal ziv-aflibercept in patients with neovascular age-related macular degeneration. METHODS: All patients received three monthly intravitreal injections of 0.05 mL of ziv-aflibercept (1.25 mg) followed by a pro re nata regimen. The best-corrected visual acuity and spectral domain optical coherence tomography were obtained at baseline and monthly. Full-field and multifocal electroretinograms were obtained at baseline and 4, 13, 26, and 52 weeks...
December 11, 2017: Retina
https://www.readbyqxmd.com/read/29199012/choroidal-changes-after-suprachoroidal-injection-of-triamcinolone-in-eyes-with-macular-edema-secondary-to-retinal-vein-occlusion
#11
Alex S Willoughby, Vivian S Vuong, David Cunefare, Sina Farsiu, Glenn Noronha, Ronald P Danis, Glenn Yiu
PURPOSE: To evaluate choroidal and suprachoroidal changes following suprachoroidal injection of triamcinolone acetonide injectable suspension (CLS-TA), in eyes with macular edema due to retinal vein occlusion (RVO). DESIGN: Prospective cohort study within a randomized, controlled phase 2 clinical trial. METHODS: Enhanced-depth imaging optical coherence tomography (EDI-OCT) images were analyzed from 38 eyes of 38 treatment naïve patients with macular edema due to RVO, enrolled in the prospective Suprachoroidal Injection of Triamcinolone Acetonide with Intravitreal Aflibercept in Subjects with Macular Edema Due to Retinal Vein Occlusion (TANZANITE) study who received either a suprachoroidal injection of CLS-TA with an intravitreal injection of aflibercept (combination arm) or only an intravitreal injection of aflibercept (monotherapy arm) followed by monthly intravitreal aflibercept injections in both arms based on pro re nata (PRN) criteria...
November 30, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29198860/comparative-of-transcranial-magnetic-stimulation-and-other-treatments-in-experimental-autoimmune-encephalomyelitis
#12
Francisco J Medina-Fernandez, Begoña M Escribano, Evelio Luque, Javier Caballero-Villarraso, Jose L Gomez-Chaparro, Montserrat Feijoo, Fe I Garcia-Maceira, Alvaro Pacual-Leone, René Drucker-Colin, Isaac Tunez
The effects of transcranial magnetic stimulation (TMS), natalizumab (nata), dimethyl fumarate (DMF) and dexamethasone (DEX) on clinical score and oxidative stress produced by a single dose of myelin oligodendrocyte glycoprotein (MOG) in tail of Dark Agouti rats was studied. TMS (60Hz and 0.7 mT), nata (5mg/kg), DMF (15mg/kg) and DEX (300μg/kg) was applied for 21 after the administration of MOG (150μg). We estimated clinical score, as well as lipid peroxides, carbonylated proteins and reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio content in brain, spinal cord and blood...
December 1, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29198482/prognosis-of-oral-cancer-a-comparison-of-the-staging-systems-given-in-the-7th-and-8th-editions-of-the-american-joint-committee-on-cancer-staging-manual
#13
G Tirelli, A Gatto, F Boscolo Nata, R Bussani, A Piccinato, A V Marcuzzo, M Tofanelli
The 8th edition of the American Joint Committee on Cancer (AJCC) Staging Manual introduces "depth of invasion" and "extranodal extension" into the head and neck section, and our aim was to find out if these changes have an impact on prognosis. We evaluated 174 patients who had had oral squamous cell carcinomas (SCC) resected between 2003 and 2012. The clinical records were reviewed, the patients' tumours restaged according to the 8th edition of the AJCC, and we analysed five-year survival to verify whether different correlations were made between the T and N stages and disease-specific survival using the 7th and 8th editions...
January 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29190241/aflibercept-after-ranibizumab-intravitreal-injections-in-exudative-age-related-macular-degeneration-the-ari2-study
#14
Rocio Blanco-Garavito, Camille Jung, Joel Uzzan, Maddalena Quaranta-ElMaftouhi, Florence Coscas, Jose Sahel, Jean-Francois Korobelnik, Stéphane Béchet, Giuseppe Querques, Eric H Souied
PURPOSE: To analyze the efficacy of aflibercept switch treatment for regression of pigment epithelial detachment (PED) in patients previously treated with ranibizumab. METHODS: Multicenter, prospective, nonrandomized clinical trial. One eye of patients presenting neovascular age-related macular degeneration with PED of more than 250 μm in height, with persistent fluid, was included. Patients had to have received at least six ranibizumab intravitreal injections during the 12 months before enrollment...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29185099/real-life-clinical-data-for-dexamethasone-and-ranibizumab-in-the-treatment-of-branch-or-central-retinal-vein-occlusion-over-a-period-of-six-months
#15
Sibylle Winterhalter, Annabelle Eckert, Gerrit-Alexander Vom Brocke, Alice Schneider, Dominika Pohlmann, Daniel Pilger, Antonia M Joussen, Matus Rehak, Ulrike Grittner
PURPOSE: To evaluate the therapeutic outcome for dexamethasone implant (DEX) or intravitreal ranibizumab (IVR) injections over 6 months in patients with macular edema due to branch or central retinal vein occlusion (BRVO, CRVO), in a real-life setting. METHODS: A total of 107 patients with BRVO or CRVO were included into this retrospective single-center observational study. Patients were treated with monotherapy consisting of DEX or three monthly IVR injections following a pro re nata regimen (PRN)...
November 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29160779/outcome-of-intravitreal-aflibercept-for-refractory-pigment-epithelial-detachment-with-or-without-subretinal-fluid-and-secondary-to-age-related-macular-degeneration
#16
Kiyoung Kim, Eung Suk Kim, Yonguk Kim, Ji Ho Yang, Seung-Young Yu, Hyung Woo Kwak
PURPOSE: To investigate the outcomes of intravitreal aflibercept in refractory pigment epithelial detachment (PED) with or without subretinal fluid (SRF) in patients with neovascular age-related macular degeneration. METHODS: A prospective, nonrandomized, interventional case series involved 40 patients with persistent vascularized PED previously treated with at least 3 injections of intravitreal bevacizumab or ranibizumab. Intravitreal aflibercept was administered as 3 initial loading doses every 4 weeks, followed by pro re nata retreatment every 8 weeks over 48 weeks...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29158071/frequency-of-and-factors-related-to-pro-re-nata-prn-medication-use-in-aged-care-services
#17
Jacquelina Stasinopoulos, J Simon Bell, Taliesin E Ryan-Atwood, Edwin C K Tan, Jenni Ilomäki, Tina Cooper, Leonie Robson, Janet K Sluggett
BACKGROUND: Little is known about the contribution of 'pro re nata' (PRN) medications to overall medication burden in residential aged care services (RACS). OBJECTIVES: To determine the frequency of, and factors associated with PRN medication administration in RACS. MEASUREMENTS: Details of all medications charted for regular or PRN use were extracted from medication charts for 383 residents of 6 Australian RACS. Records of medications administered over a 7 day period were also extracted...
November 7, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29156071/arthroscopic-repair-of-full-thickness-rotator-cuff-tears-in-active-patients-younger-than-40-years-2-to-5-year-clinical-outcomes
#18
Nata Parnes, Nicole R Bartoszewski, Michael J Defranco
This study characterized injury patterns and reported clinical outcomes of all-arthroscopic management of full-thickness rotator cuff tears among military patients younger than 40 years. A retrospective review was performed of prospective data for 42 patients younger than 40 years who underwent arthroscopic rotator cuff repair and, in some cases, concomitant labral repair. Preoperative and postoperative evaluations (minimum follow-up, 2 years; mean, 41 months; range, 24-66 months) included range of motion, visual analog scale (VAS) score, Subjective Shoulder Value (SSV), and American Shoulder and Elbow Surgeons (ASES) Shoulder Score...
November 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/29150027/tailored-resections-in-oral-and-oropharyngeal-cancer-using-narrow-band-imaging
#19
Giancarlo Tirelli, Marco Piovesana, Alberto Vito Marcuzzo, Annalisa Gatto, Matteo Biasotto, Rossana Bussani, Lorenzo Zandonà, Fabiola Giudici, Francesca Boscolo Nata
PURPOSE: In a previous pilot study we observed that intra-operative narrow-band imaging (NBI) helps achieve clear superficial resection margins. The aim of this study was to verify if the use of intra-operative NBI can help to obtain tailored resections and if it is influenced by the lesion site, aspects not investigated in our previous study. MATERIALS AND METHODS: The resection margins of 39 oral and 22 oropharyngeal squamous cell carcinomas were first set at 1...
November 10, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29130626/age-related-macular-degeneration-using-morphological-predictors-to-modify-current-treatment-protocols
#20
REVIEW
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'...
November 11, 2017: Acta Ophthalmologica
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