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Adrenaline autoinjector

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https://www.readbyqxmd.com/read/27084405/statewide-prevalence-of-school-children-at-risk-of-anaphylaxis-and-rate-of-adrenaline-autoinjector-activation-in-victorian-government-schools-australia
#1
Paxton Loke, Jennifer Koplin, Cara Beck, Michael Field, Shyamali C Dharmage, Mimi L K Tang, Katrina J Allen
BACKGROUND: The prevalence of school students at risk of anaphylaxis in Victoria is unknown and has not been previously studied. Similarly, rates of adrenaline autoinjector usage in the school environment have yet to be determined given increasing prescription rates. OBJECTIVES: We sought to determine time trends in prevalence of school children at risk of anaphylaxis across all year levels and the annual usage rate of adrenaline autoinjectors in the school setting relative to the number of students at risk of anaphylaxis...
August 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26131015/csaci-position-statement-epinephrine-auto-injectors-and-children%C3%A2-%C3%A2-15%C3%A2-kg
#2
REVIEW
Michelle Halbrich, Douglas P Mack, Stuart Carr, Wade Watson, Harold Kim
Epinephrine (adrenaline) is the treatment of choice for anaphylaxis. While other medications, including H1-antihistamines, H2-antihistamines, corticosteroids, and inhaled beta-2 agonists are often used to treat anaphylaxis in the emergency setting, none of these medications has been shown to reverse anaphylaxis. Fatal anaphylaxis is related to the delayed use of epinephrine. In community settings, epinephrine is available as an auto-injector in two doses, 0.15 mg and 0.3 mg. The recommended dose for children is 0...
2015: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/25850463/patients-ability-to-treat-anaphylaxis-using-adrenaline-autoinjectors-a-randomized-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
T Umasunthar, A Procktor, M Hodes, J G Smith, C Gore, H E Cox, T Marrs, H Hanna, K Phillips, C Pinto, P J Turner, J O Warner, R J Boyle
BACKGROUND: Previous work has shown patients commonly misuse adrenaline autoinjectors (AAI). It is unclear whether this is due to inadequate training, or poor device design. We undertook a prospective randomized controlled trial to evaluate ability to administer adrenaline using different AAI devices. METHODS: We allocated mothers of food-allergic children prescribed an AAI for the first time to Anapen or EpiPen using a computer-generated randomization list, with optimal training according to manufacturer's instructions...
July 2015: Allergy
https://www.readbyqxmd.com/read/25676800/excess-subcutaneous-tissue-may-preclude-intramuscular-delivery-when-using-adrenaline-autoinjectors-in-patients-with-anaphylaxis
#4
J Johnstone, S Hobbins, D Parekh, S O'Hickey
Intramuscular adrenaline is the gold standard treatment for anaphylaxis. Intramuscular injection provides more rapid and higher plasma concentrations than subcutaneous routes. Given the increasing epidemic of obesity patients are at increased risk of subcutaneous delivery, we therefore assessed the depth of subcutaneous tissue in a population of patients with anaphylaxis. Patients already prescribed adrenaline autoinjectors (AAIs) for anaphylaxis were examined with ultrasound, and measurements of skin-to-muscle depth (STMD) at anterolateral thigh and anterior thigh were performed...
June 2015: Allergy
https://www.readbyqxmd.com/read/25594910/factors-impacting-parental-burden-in-food-allergic-children
#5
Clare W Allen, Manasee S Bidarkar, Sheryl A vanNunen, Dianne E Campbell
AIM: This study aims to determine factors impacting the parental burden in immunoglobulin E (IgE)-mediated food-allergic children (FAC), focusing on attitudes towards adrenaline autoinjectors (AAIs). METHODS: Questionnaires were sent to parents of diagnosed IgE-mediated FAC attending follow-up allergy clinic appointments at two Sydney hospitals in May-September 2013. The questionnaires ascertained parental attitudes, confidence and knowledge regarding AAIs and included the validated, Food Allergy Quality of Life-Parental Burden (FAQL-PB) questionnaire...
July 2015: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/25525127/most-people-use-adrenaline-autoinjectors-and-asthma-inhalers-incorrectly-study-warns
#6
COMMENT
Susan Mayor
No abstract text is available yet for this article.
2014: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/25441636/anaphylaxis-unique-aspects-of-clinical-diagnosis-and-management-in-infants-birth-to-age-2-years
#7
REVIEW
F Estelle R Simons, Hugh A Sampson
In this rostrum we aim to increase awareness of anaphylaxis in infancy in order to improve clinical diagnosis, management, and prevention of recurrences. Anaphylaxis is increasingly reported in this age group. Foods are the most common triggers. Presentation typically involves the skin (generalized urticaria), the respiratory tract (cough, wheeze, stridor, and dyspnea), and/or the gastrointestinal tract (persistent vomiting). Tryptase levels are seldom increased because of infant anaphylaxis, although baseline tryptase levels can be increased in the first few months of life, reflecting mast cell burden in the developing immune system...
May 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25306896/factors-augmenting-allergic-reactions
#8
REVIEW
B Niggemann, K Beyer
Elicitors of anaphylactic reactions are any sources of protein with allergenic capacity. However, not all allergic reactions end up in the most severe form of anaphylaxis. Augmenting factors may explain why certain conditions lead to anaphylaxis. Augmenting factors may exhibit three effects: lowering the threshold, increasing the severity, and reversing acquired clinical tolerance. Common augmenting factors are physical exercise, menstruation, NSAIDs, alcohol, body temperature, acute infections, and antacids...
December 2014: Allergy
https://www.readbyqxmd.com/read/25102573/diagnosing-and-managing-peanut-allergy-in-children
#9
Rebecca Tibbott, Andrew Clark
The prevalence of peanut allergy is thought to be rising with 1 in 70 children affected in the UK. Accidental exposures are frequent and nut allergies are the leading cause of fatal food allergic reactions. Allergic reactions to peanuts are nearly always an immediate, type 1-mediated hypersensitivity response. The typical physiological response associated with such a reaction includes smooth muscle contraction, mucous secretion and vasodilatation. These responses are typically rapid in onset and can lead to systemic effects i...
June 2014: Practitioner
https://www.readbyqxmd.com/read/24865961/-status-of-children-with-food-allergy-who-were-prescribed-an-adrenaline-autoinjector-epipen
#10
Kumiko Mukaida, Takashi Kusunoki, Fumihito Nozaki, Ikuko Hiejima, Anri Hayashi, Tomohiro Kumada, Tomoko Miyajima, Tatsuya Fujii
PURPOSE: Both to evaluate the characteristics of food allergic children who were prescribed an adrenaline autoinjector and to assess whether it was used appropriately. METHODS: The characteristics of food allergic children who were prescribed an adrenaline autoinjector were investigated. Among these children, those who experienced severe anaphylaxis due to inadvertent ingestion were analyzed, as was whether and how the autoinjector was used. RESULTS: An adrenaline autoinjector was prescribed to 139 food allergic children, most often for egg, followed by milk and wheat allergies...
May 2014: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/24410783/twenty-four-hour-helpline-access-to-expert-management-advice-for-food-allergy-triggered-anaphylaxis-in-infants-children-and-young-people-a-pragmatic-randomized-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
M M Kelleher, A Dunngalvin, A Sheikh, C Cullinane, J Fitzsimons, J O'B Hourihane
BACKGROUND: Anaphylaxis is a life-threatening emergency. If promptly administered, adrenaline is potentially life-saving. Many food-allergic-children/carers are unsure when to use their adrenaline autoinjectors, contributing to a low quality of life and worse outcomes in the setting of an acute allergic reaction. OBJECTIVES: The aim of this study was to assess the effectiveness of 24-hour telephone access to specialist clinical advice on disease-specific quality of life...
December 2013: Allergy
https://www.readbyqxmd.com/read/24142945/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary-bet-3-do-doctors-know-how-to-use-adrenaline-autoinjectors-correctly
#12
REVIEW
(no author information available yet)
A short-cut review was carried out to establish whether doctors know how to use autoinjectors (for anaphylaxis). Three hundred and twenty-four papers were found of which five presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are shown in table 3. The clinical bottom line is that the majority of doctors studied are unable to use autoinjectors correctly and may therefore be unable to teach patients or parents effectively...
November 2013: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/24142944/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary-bet-2-do-parents-of-children-with-allergic-reactions-know-how-to-use-adrenaline-autoinjectors-appropriately
#13
REVIEW
(no author information available yet)
A short-cut review was carried out to establish whether the parents of children with anaphylaxis are proficient in the use of autoinjectors. Seven hundred and three papers were found of which nine presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are shown in table 2. The clinical bottom line is that competence varies widely and that further efforts are required to train and monitor training outcomes...
November 2013: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/23886232/bioavailability-of-epinephrine-from-auvi-q-compared-with-epipen
#14
RANDOMIZED CONTROLLED TRIAL
Eric S Edwards, Ronald Gunn, Estelle R Simons, Kathy Carr, Vernon M Chinchilli, Gwendolyn Painter, Ronald Goldwater
BACKGROUND: Epinephrine autoinjectors are underused for the treatment of anaphylaxis in community settings. Auvi-Q, a novel epinephrine autoinjector, was designed to be intuitive to use and reduce the potential for use-related errors. OBJECTIVE: To compare the bioavailability of 0.3 mg of epinephrine (adrenaline) injected with Auvi-Q and EpiPen in healthy adults. METHODS: In this randomized, single-blind, 2-treatment, 3-period, 3-sequence crossover study, healthy adults (18-45 years old) received a single injection of 0...
August 2013: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/23529459/anaphylaxis-identification-management-and-prevention
#15
REVIEW
Ingrid Laemmle-Ruff, Robyn O'Hehir, Michael Ackland, Mimi L K Tang
OBJECTIVE: This article summarises current knowledge regarding the identification, management and prevention of anaphylaxis, highlighting risk minimisation strategies relevant to general practitioners. DISCUSSION: The most common causes of anaphylaxis are medication, food and insect venom. Medications are the most common cause of anaphylaxis in older adults, particularly antibiotics, anaesthetic drugs, nonsteroidal anti-inflammatory drugs and opiates. Food allergy is the most common cause of anaphylaxis in children, but rarely results in death...
January 2013: Australian Family Physician
https://www.readbyqxmd.com/read/23448513/a-randomized-maternal-evaluation-of-epinephrine-autoinjection-devices
#16
RANDOMIZED CONTROLLED TRIAL
Josephine Brown, David Tuthill, Mazin Alfaham, Elizabeth Spear
BACKGROUND: Intramuscular epinephrine (adrenaline) is the first-line therapy for anaphylaxis and prompt administration improves outcome. In 2011, two epinephrine autoinjectors existed in the United Kingdom, differing in their users' administration method: EpiPen(®) and Anapen(®) . We routinely train all families who receive these devices. AIM: To evaluate: Maternal competence in using epinephrine autoinjectors following our standard anaphylaxis training package...
March 2013: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/23185847/preventing-unintentional-adrenaline-injection-with-autoinjectors
#17
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
October 2012: Prescrire International
https://www.readbyqxmd.com/read/23185846/accidental-injection-with-adrenaline-autoinjectors
#18
REVIEW
(no author information available yet)
Adrenaline (epinephrine) is the treatment of choice for severe anaphylactic reactions. Some manufacturers sell autoinjectors that patients can use for intramuscular self-injection. Case reports describing unintentional injection with these devices have been published, as well as a North American study that identified 15 190 calls to 61 US poison control centres between 1994 and 2007 and a series of 105 cases of unintentional injection reported to the US Food and Drug Administration (FDA). Errors in handling these autoinjectors, particularly by children and healthcare professionals, can result in severe consequences, including death and finger amputation, mainly due to the vasoconstriction caused by adrenaline...
October 2012: Prescrire International
https://www.readbyqxmd.com/read/23095342/a-real-life-study-on-acquired-skills-from-using-an-adrenaline-autoinjector
#19
Erdem Topal, Arzu Bakirtas, Ozlem Yilmaz, Ilbilge Hacer Ertoy, Mustafa Arga, Mehmet Sadik Demirsoy, Ipek Turktas
BACKGROUND: Training programs performed by allergists have increased the ability of patients' recognition and management of anaphylaxis. We aim to investigate the permanence of effect of an anaphylaxis training program and to determine the factors affecting it beyond training given by allergists. METHODS: Children and/or their caregivers who had been prescribed an adrenaline autoinjector at least 1 year before were invited to take part in the study. The knowledge about anaphylaxis was assessed using a questionnaire and the skills were practically tested...
2013: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/22906368/adrenaline-autoinjectors-in-food-allergy-in-for-a-cent-in-for-a-euro
#20
EDITORIAL
Bodo Niggemann, Kirsten Beyer
No abstract text is available yet for this article.
September 2012: Pediatric Allergy and Immunology
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