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JOURNAL ARTICLE
Toshiaki Kawano, Akihiro Takase, Daisuke Yasunari, Chikako Motomura, Masanori Ikeda, Teruaki Matsui, Mika Ogata, Shuichi Suzuki, Junichiro Tezuka, Mizuho Nagao, Natsuko Masumoto, Noriyuki Yanagida, Yukihiro Ohya
OBJECTIVE: Quality of life (QOL) questionnaires for parents of children with food allergies have been developed in the United States and Europe. However, no original Japanese QOL questionnaire has been developed till date. We aimed to develop an original questionnaire to evaluate the QOL in parents of children with food allergies in Japan. METHODS: We collected QOL-related questions from parents of children with food allergies aged 0-15 years, and created a primary questionnaire...
2024: Arerugī, [Allergy]
#2
JOURNAL ARTICLE
Sebastian Vigand Svendsen, Annemarie Schaeffer Senders, Athamaica Ruiz Oropeza, Annmarie Lassen, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen, Charlotte G Mortz
No abstract text is available yet for this article.
March 15, 2024: Clinical and Experimental Allergy
#3
REVIEW
Agnieszka Rydz, Magdalena Lange, Hanna Ługowska-Umer, Monika Sikorska, Roman J Nowicki, Cristina Morales-Cabeza, Iván Alvarez-Twose
Mastocytosis is a heterogeneous disease characterized by the expansion and accumulation of neoplastic mast cells in various tissues. Diffuse cutaneous mastocytosis (DCM) is a rare and most severe form of cutaneous mastocytosis, which typically occurs in childhood. There have been reports of a familial DCM with specific gene mutations, indicating both sporadic and hereditary factors involved in its pathogenesis. DCM is associated with severe MC mediator-related symptoms and an increased risk of anaphylaxis. The diagnosis is based on the appearance of skin lesions, which typically show generalized thickening, erythroderma, blistering dermographism, and a positive Darier's sign...
January 23, 2024: International Journal of Molecular Sciences
#4
JOURNAL ARTICLE
Agnes Sze Yin Leung, Ruby Pawankar, Punchama Pacharn, Lydia Su Yin Wong, Duy Le Pham, Grace Chan, Iris Rengganis, Jing Zhao, Jiu Yao Wang, Kent Chee-Keen Woo, Komei Ito, Kyunguk Jeong, Marysia Recto, Michaela Lucas, Mizuho Nagao, Rommel Crisenio M Lobo, Sonomjamts Munkhbayarlakh, Sumadiono Sumadiono, Syed Rezaul Huq, Thushali Ranasinghe, Mimi Tang
BACKGROUND: Food allergy (FA), which is a condition that has no effective cure and can result in severe life-threatening allergic reactions, remains a global public health concern; however, little is known about how FAs are currently managed in the Asia-Pacific region. OBJECTIVE: The main objective of this survey was to evaluate the epidemiology of FA, as well as the availability of resources and practices for management of FA and anaphylaxis by health care providers across Asia...
May 2024: J Allergy Clin Immunol Glob
#5
REVIEW
Margitta Worm, Adam T Fox, Magnus Wickman, Johannes Ring, Motohiro Ebisawa, Guillaume Pouessel, Pete Smith
BACKGROUND: Anaphylaxis is a sudden multisystem allergic reaction which may result in a fatal outcome if not treated promptly. Guidelines worldwide suggest intramuscular adrenaline as the first-line treatment for anaphylaxis outside a perioperative reaction. Adrenaline autoinjectors (AAIs) are widely used self-administrable devices, especially in community settings. Different commercial AAIs have been authorized to be marketed in Europe. For an AAI to be efficacious, a rapid adrenaline delivery in patients, including those who are overweight or obese, resulting in an optimal cardiovascular (CV) response, is a key feature...
December 2023: Clinical and Translational Allergy
#6
JOURNAL ARTICLE
Louise Parke, Henrik Fomsgaard Kjaer, Olav Sivertsen Garvik, Susanne Halken, Sigurd Broesby-Olsen, Carsten Bindslev-Jensen, Charlotte G Mortz
INTRODUCTION: Venom immunotherapy (VIT) and adrenaline autoinjector (AAI) are important therapies in venom anaphylaxis. Adherence to VIT and AAI in patients with venom allergy has been evaluated in a few studies; however, solid data are lacking. This study aimed to evaluate VIT and AAI retrieval rates in patients with venom allergy with a special focus on adherence to treatment. Adherence was compared to subcutaneous immunotherapy (SCIT) with inhalant allergens. METHODS: This was a retrospective study among patients registered for allergen immunotherapy at the Allergy Center, Odense University Hospital, Denmark, from January 1, 2010, to December 31, 2014...
December 5, 2023: International Archives of Allergy and Immunology
#7
JOURNAL ARTICLE
Matija Rijavec, Jezerka Inkret, Urška Bidovec-Stojković, Tanja Carli, Nina Frelih, Andreja Kukec, Peter Korošec, Mitja Košnik
Hymenoptera venom-triggered anaphylaxis (HVA) affects up to 8.9% of the general population and is the most frequent cause of anaphylaxis in adults, accounting for approximately 20% of all fatal anaphylaxis cases. Quite often, a fatal reaction is a victim's first manifestation of HVA. Mastocytosis represents one of the most important risk factors for severe HVA. We analyzed patients with documented fatal HVA for the presence of underlying clonal mast cell disorder (cMCD). Here, we report three cases of fatal HVA, with undiagnosed underlying cMCD identified by the presence of the peripheral blood and/or bone marrow KIT p...
November 15, 2023: International Journal of Molecular Sciences
#8
JOURNAL ARTICLE
Thomas J Wiseman, Joshua G Kovoor, Melinda Jiang, Brandon Stretton, Aashray K Gupta, Stephen Bacchi, Frank E Kette
Intramuscular adrenaline autoinjectors are accepted as first-line treatment for out-of-hospital anaphylaxis but face ongoing issues of patient non-adherence related to drug expiry, availability, correct administration, and public recognition of the disease. Adrenaline is associated with possible harms in patients with defined comorbidities, but is still considered preferable. Further research and policy is required to facilitate the effective treatment of anaphylaxis. This article is protected by copyright...
November 5, 2023: Internal Medicine Journal
#9
JOURNAL ARTICLE
Valerie Chiang, Hugo W F Mak, Maegan H Y Yeung, Andy K C Kan, Elaine Y L Au, Philip H Li
BACKGROUND: Anaphylaxis is a life-threatening allergic reaction that poses a considerable burden on populations across all ethnicities and age groups. The Hong Kong Multidisciplinary Anaphylaxis Management Initiative (HK-MAMI) was established to streamline the assessment of patients with anaphylaxis via a multidisciplinary and protocol-driven approach. OBJECTIVE: This prospective study aims to define the etiology, clinical manifestations, and treatment of patients with anaphylaxis in Hong Kong...
August 2023: J Allergy Clin Immunol Glob
#10
JOURNAL ARTICLE
Tugba Guler, Ilknur Kulhas Celik, Meltem Comert, Hasibe Artac
Background: Seeds are widely consumed as a traditional snack and have rich contents beneficial to health. With an increase in consumption rates, allergic reactions occur more frequently. We focus on multiple seed consumption related to recurrent anaphylaxis in this case. Case Presentation: We evaluated an 11-year-old boy with recurrent anaphylaxis. According to his medical records, he had been hospitalized several times, diagnosed with anaphylaxis, and treated. The family noticed direct (eating) or indirect contact with pumpkin seeds...
September 2023: Pediatric Allergy, Immunology, and Pulmonology
#11
REVIEW
Valentina Faihs, Claudia Kugler, Viktoria Schmalhofer, Katharina Anne Scherf, Barbara Lexhaller, Charlotte G Mortz, Carsten Bindslev-Jensen, Tilo Biedermann, Knut Brockow
Wheat-dependent exercise-induced anaphylaxis (WDEIA) is an IgE-mediated food allergy with allergic symptoms ranging from intermittent urticaria to severe anaphylaxis that occurs when wheat ingestion is combined with augmenting cofactors such as exercise, non-steroidal anti-inflammatory drugs, or alcohol. In most cases, patients are identified by sensitization to ω5-gliadins in the gluten fraction of wheat. ω5-gliadin-negative subtypes of WDEIA are often difficult to diagnose and may be caused by Tri a 14 (wheat lipid transfer protein), after percutaneous sensitization with hydrolyzed wheat proteins, or, in rare cases, by cross-reactivity to grass pollen...
July 18, 2023: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
#12
REVIEW
Jay A Lieberman, John Oppenheimer, Vivian P Hernandez-Trujillo, Michael S Blaiss
PURPOSE OF REVIEW: The current standard of first-line emergency treatment of anaphylaxis is intramuscular (IM) epinephrine, mostly administered through epinephrine autoinjector (EAI) in the outpatient setting. However, undercarriage and underuse of EAIs are common, and delayed epinephrine use is associated with increased morbidity and mortality. Patients, caregivers, and healthcare professionals have expressed a strong desire for small, needle-free devices and products that would offer improved carriage, ease of use, and more convenient, less invasive routes of epinephrine administration...
August 2023: Annals of Allergy, Asthma & Immunology
#13
JOURNAL ARTICLE
Gavriela Feketea, John Lakoumentas, Evangelia Papatriantafyllou, Nikolaos Douladiris, Dimitris Efthymiou, Luminita Aurelia Stanciu, Emilia Vassilopoulou
BACKGROUND: Schoolchildren are likely to consume meals and snacks at school, with a possibility of allergic food reactions and anaphylaxis in the school environment. The school personnel should be informed of the presence of schoolchildren with food allergy (FA) and need to be trained in the management of allergic reactions, as to prepare them to intervene appropriately when necessary. Limited knowledge of FA and its management is documented globally among school staff and there is no uniform protocol in schools...
March 11, 2023: Children
#14
REVIEW
Timothy E Dribin, Susan Waserman, Paul J Turner
International guidelines stipulate that intramuscular (IM) epinephrine (adrenaline) is the first line treatment for anaphylaxis, with an established good safety profile. The availability of epinephrine autoinjectors (EAI) has greatly facilitated the lay-administration of IM epinephrine in community settings. However, key areas of uncertainty remain around epinephrine usage. These include variations in prescribing EAI, what symptoms should prompt epinephrine administration, whether Emergency Medical Services need to be contacted after administration, and whether epinephrine administered via EAI reduces mortality from anaphylaxis or improves quality of life measures...
February 14, 2023: Journal of Allergy and Clinical Immunology in Practice
#15
JOURNAL ARTICLE
Nandinee Patel, Emily Isaacs, Bettina Duca, Nanthagopan Nagaratnam, Jackie Donovan, Sara Fontanella, Paul J Turner
BACKGROUND: Guidelines recommend intramuscular injection of 500 μg adrenaline (epinephrine) for anaphylaxis in teenagers and adults; however, most autoinjectors deliver a maximum 300 μg dose. We evaluated plasma adrenaline levels and cardiovascular parameters (including cardiac output) following self-injection with 300 μg or 500 μg adrenaline in teenagers at risk of anaphylaxis. METHODS: Subjects were recruited to a randomized, single-blind two period crossover trial...
February 16, 2023: Allergy
#16
JOURNAL ARTICLE
Nikolaos Pyrpyris, Maria Kritikou, Xenofon Aggelidis, Ioanna Manolaraki, Michael Makris, Nikolaos G Papadopoulos, Paraskevi Xepapadaki
The European Anaphylaxis Registry (NORA) was designed in order to create a comprehensive Anaphylaxis Registry regarding anaphylactic reactions characteristics and management in several European countries, including Greece. This study aims to analyze Greek data obtained in the NORA framework and describe anaphylaxis' characteristics in this pediatric cohort. An online questionnaire was filled out by the Allergy Unit of the 2nd Pediatric Department of NKUA, regarding reported anaphylaxis characteristics. A total of 284 pediatric patients were analyzed...
September 30, 2022: Journal of Personalized Medicine
#17
JOURNAL ARTICLE
Sa-Eeda Chippendale, Kirsten Reichmuth, Margitta Worm, Michael Levin
Introduction: Anaphylaxis is a severe, life-threatening generalized hypersensitivity reaction. While guidelines to reduce the morbidity, risk, and mortality of anaphylaxis are widely available, adherence to these is often suboptimal. We aimed to audit paediatric anaphylaxis at a South African tertiary allergy referral centre, comparing our data to those of the large Network of Severe Allergic Reactions (NORA) registry. Methods: Children treated for severe allergic reactions between January 2014 and August 2016 were identified for screening using ICD-10 coding of all admissions and discharges, pharmacy records of adrenaline autoinjector dispensing, and additional referrals from the allergy department to the study...
September 2022: World Allergy Organization Journal
#18
REVIEW
Juan Trujillo, Caoimhe Cronin
BACKGROUND AND OBJECTIVE: The incidence of food allergy among children is on the rise. Children who are diagnosed with a food allergy receive long-term treatment for allergy management from allergy specialists, nurses and dieticians. This management may include the prescription of an adrenaline autoinjector (AAI) if the child is at risk of a severe allergic reaction (anaphylaxis). Therefore, it is important that parents of children with allergies are trained in the recognition of anaphylaxis and in the correct administration of an AAI...
2022: Allergologia et Immunopathologia
#19
JOURNAL ARTICLE
Tim Brettig, Kim Dalziel, Jennifer J Koplin, Thanh Dang, Lars Lange, Vicki McWilliam, Sakura Sato, Savvas Savvatianos, Kirsten P Perrett
BACKGROUND: In the absence of a clear clinical history of reaction, diagnosis of cashew allergy using skin prick tests (SPT) or cashew-specific IgE requires a high number of oral food challenges (OFC). By using Ana o 3 sIgE alone, or a two-step diagnostic algorithm using cashew sIgE followed by Ana o 3 sIgE, there is a reduced need for OFC. We aimed to perform a cost comparison for both of these approaches compared with cashew SPT alone. METHODS: Pooled individual-level data from 6 studies were used to determine diagnostic accuracy and OFC rate...
August 2022: Pediatric Allergy and Immunology
#20
JOURNAL ARTICLE
Mojca Bizjak, Mitja Košnik, Dejan Dinevski, Simon Francis Thomsen, Daria Fomina, Elena Borzova, Kanokvalai Kulthanan, Raisa Meshkova, FernandoM Aarestrup, Dalia Melina Ahsan, Mona Al-Ahmad, Sabine Altrichter, Andrea Bauer, Maxi Brockstädt, Célia Costa, Semra Demir, Roberta Fachini Criado, Luis Felipe Ensina, Asli Gelincik, Ana Maria Giménez-Arnau, Margarida Gonçalo, Maia Gotua, Jesper Grønlund Holm, Naoko Inomata, Alicja Kasperska-Zajac, Maryam Khoshkhui, Aliya Klyucharova, Emek Kocatürk, Rongbiao Lu, Michael Makris, Natalya Maltseva, Maria Pasali, Marisa Paulino, David Pesqué, Jonny Peter, German Dario Ramón, Carla Ritchie, Solange Oliveira Rodrigues Valle, Michael Rudenko, Agnieszka Sikora, Nicola Wagner, Paraskevi Xepapadaki, Xiaoyang Xue, Zuotao Zhao, Dorothea Terhorst-Molawi, Marcus Maurer
Background: The diagnosis of typical cold urticaria (ColdU) relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). Till date, it is largely unclear how often patients with ColdU receive adrenaline treatment and are provided with an adrenaline autoinjector (AAI). Methods: An international, cross-sectional study, COLD-CE (i.e., comprehensive evaluation of ColdU and other cold-induced reactions), was carried out at 32 UCAREs. Detailed histories were taken and CST with an ice cube and/or TempTest® performed...
2022: Qatar Medical Journal
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