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Postpartum Thyroiditis

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https://www.readbyqxmd.com/read/29774380/-thyroid-and-pregnancy
#1
REVIEW
K A Iwen, H Lehnert
During pregnancy thyroid hormones have profound effects on embryonal/fetal development and maternal health. Therefore, thyroid gland disorders should be immediately diagnosed and adequately treated. Pregnancy-specific physiological alterations during pregnancy cause changes in the reference interval for thyroid-stimulating hormone levels and trimester-specific thresholds must be taken into account. This article summarizes the most important diagnostic and therapeutic aspects before, during and after pregnancy...
May 17, 2018: Der Internist
https://www.readbyqxmd.com/read/29767691/thyroid-hormones-and-female-reproduction
#2
Juneo F Silva, Natália M Ocarino, Rogéria Serakides
Thyroid hormones are vital for the proper functioning of the female reproductive system, since they modulate the metabolism and development of ovarian, uterine and placental tissues. Therefore, hypo- and hyperthyroidism may result in subfertility or infertility in both women and animals. Other well-documented sequelae of maternal thyroid dysfunctions include menstrual/estral irregularity, anovulation, abortion, preterm delivery, preeclampsia, intrauterine growth restriction, postpartum thyroiditis, and mental retardation in children...
May 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29686830/cytomorphological-spectrum-of-thyroiditis-a-review-of-110-cases
#3
Shirish S Chandanwale, Rahul Nair, Anushree Gambhir, Supreet Kaur, Aditi Pandey, Abhinav Shetty, Piyusha Naragude
Introduction: Different types of thyroiditis may share some parallel clinical and biochemical features. Timely intervention can significantly reduce morbidity and mortality. Aim: Aim of this study is to find the frequency of various thyroiditis, study the cytomorphological features and correlate with clinical findings including radiological findings, thyroid function test, and anti-thyroid peroxidase antibodies (Anti-TPO antibodies). Materials and Methods: The study included consecutive 110 cases of thyroiditis...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29683911/acog-committee-opinion-no-736-optimizing-postpartum-care
#4
(no author information available yet)
The weeks following birth are a critical period for a woman and her infant, setting the stage for long-term health and well-being. To optimize the health of women and infants, postpartum care should become an ongoing process, rather than a single encounter, with services and support tailored to each woman's individual needs. It is recommended that all women have contact with their obstetrician-gynecologists or other obstetric care providers within the first 3 weeks postpartum. This initial assessment should be followed up with ongoing care as needed, concluding with a comprehensive postpartum visit no later than 12 weeks after birth...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683906/acog-committee-opinion-no-736-summary-optimizing-postpartum-care
#5
(no author information available yet)
The weeks following birth are a critical period for a woman and her infant, setting the stage for long-term health and well-being. To optimize the health of women and infants, postpartum care should become an ongoing process, rather than a single encounter, with services and support tailored to each woman's individual needs. It is recommended that all women have contact with their obstetrician-gynecologists or other obstetric care providers within the first 3 weeks postpartum. This initial assessment should be followed up with ongoing care as needed, concluding with a comprehensive postpartum visit no later than 12 weeks after birth...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29645066/intellectual-performance-of-children-of-mothers-with-an-untreated-thyroid-disorder-in-the-first-pregnancy-trimester
#6
Irena Komendová, Sylvie Špitálníková
INTRODUCTION: The focus of the present study was the importance of the mother's thyroid function for foetal development in the first trimester, when the baby is totally dependent on the mother for thyroid hormones. MATERIAL AND METHODS: The study consisted in testing the intellectual performance of children with both euthyroid and thyroid-dysfunction mothers. The experimental group comprised 60 children of mothers with an untreated thyroid disorder in the first trimester of their pregnancy (TSH≥3...
April 12, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29644934/management-of-subclinical-hypothyroidism-in-pregnancy-a-comment-from-the-italian-society-of-endocrinology-sie-and-the-italian-thyroid-association-ait-to-the-2017-ata-guidelines-the-italian-way
#7
Mario Rotondi, Luca Chiovato, Furio Pacini, Luigi Bartalena, Paolo Vitti
The 2017 ATA Guidelines for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum were published six years after the previous ones. They provide comprehensive clinical recommendations for the whole spectrum of thyroid diseases as well as for optimal iodine intake during pregnancy, post-partum and lactation. The present position statement mainly regards the recommended flow-chart for therapeutic decision making in pregnant women being diagnosed with subclinical hypothyroidism. The major biochemical and clinical situations and the corresponding therapeutic indications will be commented...
April 12, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29561188/short-term-sitagliptin-metformin-therapy-is-more-effective-than-metformin-or-placebo-in-prior-gestational-diabetic-women-with-impaired-glucose-regulation
#8
Karen E Elkind-Hirsch, Martha S Paterson, Donna Shaler, Hanh C Gutowski
OBJECTIVE: Our pilot study examined the effectiveness of sitagliptin-metformin (SITA-MET), metformin (MET), and placebo (P) therapy on fasting and post-glucose challenge glucose levels in postpartum women with prior gestational diabetes mellitus (GDM) and impaired glucose regulation. METHODS: Prediabetic women (N = 36, age 18 to 42 years) with recent GDM were randomized to P (one pill twice a day), MET (1,000 mg twice a day), or SITA-MET (50 mg SITA, 1,000 mg MET twice a day) for 16 weeks in a single-blind fashion...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29488882/maternal-plasma-per-and-polyfluoroalkyl-substance-concentrations-in-early-pregnancy-and-maternal-and-neonatal-thyroid-function-in-a-prospective-birth-cohort-project-viva-usa
#9
Emma V Preston, Thomas F Webster, Emily Oken, Birgit Claus Henn, Michael D McClean, Sheryl L Rifas-Shiman, Elizabeth N Pearce, Lewis E Braverman, Antonia M Calafat, Xiaoyun Ye, Sharon K Sagiv
BACKGROUND: Prenatal exposure to some per- and polyfluoroalkyl substances (PFASs) may disrupt maternal and neonatal thyroid function, which is critical for normal growth and neurodevelopment. OBJECTIVES: We examined associations of PFAS exposure during early pregnancy with maternal and neonatal thyroid hormone levels. METHODS: We studied 732 mothers and 480 neonates in Project Viva, a longitudinal prebirth cohort in Boston, Massachusetts. We quantified six PFASs, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), and maternal thyroid hormones [thyroxine (T4 ), Free T4 Index (FT4 I), thyroid stimulating hormone (TSH)] in plasma samples collected at a median 9...
February 27, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29375183/thyroid-disorders-in-pregnancy-and-postpartum
#10
REVIEW
Ashleigh Smith, Jade Eccles-Smith, Michael D'Emden, Karin Lust
No abstract text is available yet for this article.
December 2017: Australian Prescriber
https://www.readbyqxmd.com/read/29187947/macroprolactinemia-and-empty-sella-syndrome
#11
Ach Taieb, Kacem Njah Maha, Yosra Hasni El Abed, Amel Maaroufi Beizig, Molka Chaieb Chadli, Koussay Ach
Macroprolactinemia is a polymeric form of prolactin-release, causing mildly symptomatic clinical pictures. The former can be isolated or associated with other causes of hyperprolactinemia. The association with an empty sella syndrome is rare. We report a case of a female patient discovered with this association. It's about a female patient 47 years old, followed up since the age of 31 years for bilateral galactorrhea and a spaniomenorrhea. There has been no associated drug intake. Her exploration has showed a serum prolactin level of 635 mIU/L...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29187511/pregnancy-outcomes-are-not-altered-by-variation-in-thyroid-function-within-the-normal-range-in-women-free-of-thyroid-disease
#12
Flora Veltri, Pierre Kleynen, Lidia Grabczan, Alexandra Salajan, Serge Rozenberg, Thierry Pepersack, Kris Poppe
OBJECTIVE: In the recently revised guidelines on the management of thyroid dysfunction during pregnancy, treatment with thyroid hormone (LT4) is not recommended in women without thyroid autoimmunity (TAI) and TSH levels in the range 2.5-4.0 mIU/L, and in a recent study in that particular group of pregnant women, more complications were observed when a treatment with LT4 was given. The objective of the study was therefore to investigate whether variation in thyroid function within the normal (non-pregnant) range in women free of thyroid disease was associated with altered pregnancy outcomes? DESIGN: Cross-sectional data analysis of 1321 pregnant women nested within an ongoing prospective collection of pregnant women's data in a single centre in Brussels, Belgium...
February 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29166819/pregnancy-outcomes-among-women-with-asthma
#13
Haitham Baghlaf, Andrea R Spence, Nicholas Czuzoj-Shulman, Haim Arie Abenhaim
PURPOSE: The purpose of this study is to examine the association between maternal asthma and pregnancy, delivery and neonatal outcomes. MATERIALS AND METHODS: We carried out a retrospective cohort study using the Health Care Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database from 2003 to 2011. Among women who delivered during this time period, we compared pregnancy, delivery, and neonatal outcomes in asthmatics versus non-asthmatics. Multivariate logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals...
November 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29160171/recent-pregnancy-is-not-associated-with-high-risk-pathological-features-of-well-differentiated-thyroid-cancer
#14
Angela C Chen, Masha J Livhits, Lin Du, James X Wu, Eric J Kuo, Michael W Yeh, Angela M Leung
BACKGROUND: Thyroid cancer is commonly diagnosed in the first postpartum year, supporting the theory that high levels of estrogen may stimulate progression of hormone-mediated thyroid cancer. The aim of this study was to assess the effect of recent pregnancy on histopathologic disease characteristics of well-differentiated thyroid cancer (WDTC). METHODS: Cases of WDTC (1999-2012) were identified from the California Cancer Registry and linked to data from the Office of Statewide Health Planning and Development...
January 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29079883/distinct-hormonal-regulation-of-two-types-of-sexual-dimorphism-in-submandibular-gland-of-mice
#15
Miyuki Yamamoto, Hiroki Nakata, Tewarat Kumchantuek, Kannika Adhapanyawanich, Shoichi Iseki
The submandibular gland (SMG) of mice exhibits prominent sexual dimorphism in two aspects: the preferential development of granular convoluted tubule (GCT) cells and the earlier disappearance of granular intercalated duct (GID) cells in males after puberty. The former is dependent on androgens and thyroid hormones, whereas the hormonal dependence of the latter remains obscure. In the present study, we examined the effects of the postnatal administration of androgens and thyroid hormones to wild-type (WT) and androgen-receptor-knockout (ARKO) mice on these two types of sexual dimorphism by counting the numbers of GCT and GID cells labeled with nerve growth factor and submandibular gland protein C, respectively, as immunohistochemical markers...
February 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29067240/benign-thyroid-disease-in-pregnancy-a-state-of-the-art-review
#16
REVIEW
Efterpi Tingi, Akheel A Syed, Alexis Kyriacou, George Mastorakos, Angelos Kyriacou
Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase. Maternal thyroid dysfunction during pregnancy may have significant adverse maternal and fetal outcomes such as preterm delivery, preeclampsia, miscarriage and low birth weight. In this review we discuss the effect of thyroid disease on pregnancy and the current evidence on the management of different thyroid conditions in pregnancy and postpartum to improve fetal and neonatal outcomes, with special reference to existing guidelines on the topic which we dissect, critique and compare with each other...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29032108/pregnancy-induced-changes-in-corneal-biomechanics-and-topography-are-thyroid-hormone-related
#17
David Tabibian, Begoña M de Tejada, Zisis Gatzioufas, Sabine Kling, Vanessa S Meiss, Marc-Olivier Boldi, Véronique Othenin-Girard, Antonina Chilin, Julien Lambiel, Florence Hoogewoud, Farhad Hafezi
PURPOSE: To identify biomechanical and topographic changes of the cornea during pregnancy and the postpartum period and its association to hormonal changes. DESIGN: Prospective single-center observational cohort study. METHODS: Participants were 24 pregnant women (48 eyes), monitored throughout pregnancy and after delivery. Biomechanical and topographic corneal properties were measured using the Ocular Response Analyzer (ORA) and a Scheimpflug imaging system (Pentacam HR) each trimester and 1 month after delivery...
December 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29026609/ketosis-prone-diabetes-and-sle-co-presenting-in-an-african-lady-with-previous-gestational-diabetes
#18
S Hussain, S Keat, S V Gelding
We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). However, the diagnosis of SLE prompted testing for an autoimmune aetiology for the diabetes, and she was found to have a very high titre of GAD antibodies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29022126/a-systematic-review-of-cortisol-thyroid-stimulating-hormone-and-prolactin-in-peripartum-women-with-major-depression
#19
REVIEW
Mercedes J Szpunar, Barbara L Parry
Pregnancy and postpartum are periods of high susceptibility to major depression (MD) and other mood disorders. The peripartum period is also a time of considerable changes in the levels of hormones, including cortisol, thyroid-stimulating hormone (TSH), prolactin, gonadotropins, and gonadal steroids. To investigate the relationship between mood and hormonal changes during and after pregnancy, we reviewed published reports of hormonal measures during this time frame, searched via PubMed and Web of Science. Studies were included if women in the antepartum or postpartum periods were clinically diagnosed with MD, and if there were repeated measures of cortisol, TSH, or prolactin...
April 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28989877/postpartum-follow-up-in-women-diagnosed-with-subclinical-hypothyroidism-during-pregnancy
#20
K Neelaveni, K V S Hari Kumar, Rakesh Sahay, Jayanthy Ramesh
BACKGROUND: Management guidelines about the thyroid disease in pregnancy are silent about the postpartum course of new onset subclinical hypothyroidism (SCH). Hence, we analyzed the 2 years outcome of SCH diagnosed during pregnancy. MATERIALS AND METHODS: We conducted this retrospective study using the medical records of patients with new onset SCH during pregnancy between 2010 and 2013 ( n = 718). Patients who stopped their levothyroxine after delivery with a 2-year follow-up record were included...
September 2017: Indian Journal of Endocrinology and Metabolism
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