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troponin creatine kinase

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https://www.readbyqxmd.com/read/29335079/-expression-of-plasma-mirna-497-in-children-with-sepsis-induced-myocardial-injury-and-its-clinical-significance
#1
Zhong-Jing Wu, Ya-Feng Chen, Hai-Dao Wang, Fang-Hong Gao
OBJECTIVE: To study the expression of plasma miRNA-497 in children with sepsis-induced myocardial injury and its clinical significance. METHODS: A total of 148 children with sepsis were enrolled. According to the presence or absence of myocardial injury, these children were divided into myocardial injury group (n=58) and non-myocardial injury group (n=90). The two groups were compared in terms of the changes in plasma levels of miRNA-497, cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), N-terminal pro-brain natriuretic peptide (NT-proBNP), procalcitonin (PCT), and C-reactive protein (CRP) and left ventricular ejection fraction (LVEF)...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29334742/-diagnostic-and-prognostic-biomarkers-in-acute-coronary-syndrome
#2
Petr Kuběna, Jindřich Špinar, Milan Dastych, Petr Lokaj, Jiří Pařenica
Acute myocardial infarction (AMI) is an important cause of mortality and morbidity worldwide. Early diagnostics of this disease helps in the appropriate treatment of patients. Great attention is paid to the diagnostic and risk stratification of patients according to circulating biomarkers. There are a lot of scientific publications describing this topic. The aim of this article is to provide a comprehensive overview of the most important and most examined biomarkers in acute coronary syndrome. Meanwhile troponin takes a fundamental place for AMI diagnostic (mostly the high-sensitive methods) in preference to MB-fraction of creatine kinase and myoglobin...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29325455/influence-of-middle-distance-running-on-muscular-micro-rnas
#3
Elisa Danese, Marco Benati, Fabian Sanchis-Gomar, Cantor Tarperi, Gian Luca Salvagno, Elisa Paviati, Martina Montagnana, Federico Schena, Giuseppe Lippi
A specific subset of micro RNAs (miRs), including miR-133 and miR-206, is specifically expressed in muscle tissue, so that they are currently defined as muscular miRs (myomiRs). To further elucidate the role of myomiRs in muscle biology, we measured miR-133a and miR-206 in plasma of 28 middle-age recreational athletes. The study population consisted of 28 middle aged, recreation athletes (11 women and 17 men; mean age, 46 years) who completed a 21.1 km, half-marathon. The plasma concentration of miR-133a and miR-206, the serum concentration of creatine kinase (CK) and high-sensitivity (HS) cardiac troponin T (cTnT), as well as capillary lactate, were measured before and immediately after the run...
January 11, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29325368/-the-effects-and-related-mechanism-of-salvianolate-on-rats-with-myocardial-ischemia-reperfusion-injury
#4
R C Yue, X L Yang, R Y Zhang, S Liu, J Liu, J Zeng, H Liang, W Wang, H X Hu, C Y Zeng
Objective: To investigate the effect and related mechanism of salvianolate on myocardial ischemia-reperfusion (I/R) injury in rats. Methods: Thirty-six adult Sprague-Dawley rats were divided into three groups (n=12 each) using random number table method: control group (coronary artery was not ligated) , I/R group (myocardial I/R model was established by ligation and opening of left anterior descending coronary artery) , and salvianolate+I/R group (5 mg/kg of salvianolate was injected through the tail vein at the time of reperfusion) ...
December 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29325364/-the-efficacy-and-safety-of-coil-embolization-of-septal-branch-in-the-treatment-of-patients-with-obstructive-hypertrophic-cardiomyopathy
#5
H Liu, Q Wu, H W Tan, J Pang
Objective: To observe the clinical efficacy and safety of coil embolization of septal branch in the treatment of obstructive hypertrophic cardiomyopathy (HOCM). Methods: Eighteen patients with HOCM hospitalized in our department from September 2014 to October 2016 were enrolled in this study. There were 12 males and 6 females in this cohort and the age of patients ranged from 22 to 64 years old. Left ventricular outflow tract gradient (LVOTG) was derived from echocardiographic apical five-chamber view at pre-operation and at 48 hours and 6 months post operation...
December 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29322434/protection-from-reperfusion-injury-with-intracoronary-n-acetylcysteine-in-patients-with-stemi-undergoing-primary-percutaneous-coronary-intervention-in-a-cardiac-tertiary-center
#6
Younes Nozari, Azadeh Eshraghi, Azita Hajhossein Talasaz, Mostafa Bahremand, Jamshid Salamzadeh, Mojtaba Salarifar, Hamidreza Pourhosseini, Arash Jalali, Seyedeh Hamideh Mortazavi
BACKGROUND: Evidence suggests that oxidative stress plays a principal role in myocardial damage following ischemia/reperfusion events. Recent studies have shown that the antioxidant properties of N-acetylcysteine (NAC) may have cardioprotective effects in high doses, but-to the best of our knowledge-few studies have assessed this. OBJECTIVES: Our objective was to investigate the impact of high-dose NAC on ischemia/reperfusion injury. METHODS: We conducted a randomized double-blind placebo-controlled trial in which 100 consecutive patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) were randomly assigned to the case group (high-dose NAC 100 mg/kg bolus followed by intracoronary NAC 480 mg during PCI then intravenous NAC 10 mg/kg for 12 h) or the control group (5% dextrose)...
January 10, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29312582/shexiang-tongxin-dropping-pill-protects-against-isoproterenol-induced-myocardial-ischemia-in-vivo-and-in-vitro
#7
Jianyong Qi, Wenjun Pan, Yafang Tan, Jiaru Luo, Dancai Fan, Juan Yu, Jiashin Wu, Minzhou Zhang
Shexiang Tongxin dropping pill (STDP) is a formulae of Chinese Medicine commonly used to treating angina pectoris in China. However, its mechanism of action is still yet unclear. This study investigated the roles of STDP on myocardial ischemia injury. We constructed a rat model of myocardial injury (isoproterenol subcutaneous injection, i.h, 85 mg/kg/day for 2 days), and compared among 4 groups: CON (control), ISO (ischemic injury model), MET (metoprolol), and STDP. Serum contents of Troponin I (cTnI), creatine kinase (CK), CK-MB, lactate dehydrogenase (LDH), alpha-hydroxybutyric dehydrogenase (α-HBD), and Aspartate Aminotransferase were detected and five STDP doses (1, 10, 100, 1000 and 10000 mg/kg/day) were chosen to obtain a dose-response curve...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29303408/forensic-tools-for-the-diagnosis-of-electrocution-death-case-study-and-literature-review
#8
Cristina Mondello, Antonio Micali, Luigi Cardia, Antonina Argo, Stefania Zerbo, Elvira Ventura Spagnolo
Diagnosis of death by electrocution may be difficult when electric marking is not visible or unclear. Accordingly, the body of a man who appeared to have died from accidental electrocution was carefully forensically analysed. Macroscopic and microscopic analysis of the current mark was carried out using a variable-pressure scanning electron microscope equipped with energy dispersive X-ray microanalyser to highlight skin metallisation, indicating the presence of iron and zinc. The histological findings of electrocution myocardial damage were supported by the results of biochemical analysis which demonstrated the creatine kinase-MB and cardiac troponin I elevation...
January 1, 2018: Medico-legal Journal
https://www.readbyqxmd.com/read/29285428/prognostic-performance-of-combined-use-of-high-sensitivity-troponin-t-and-creatine-kinase-mb-isoenzyme-in-high-cardiovascular-risk-patients-with-end-stage-renal-disease
#9
Khaled Abdul-Aziz Ahmed, Wahda Mohammed Al-Attab
Background: The principal goal of this study was to determine the importance of high-sensitivity troponin T (hs-TnT) and creatine kinase MB isoenzyme (CK-MB) in predicting cardiovascular events in asymptomatic end-stage renal disease (ESRD) patients. Methods: This study included 110 participants; 54 ESRD patients undergoing hemodialysis and 56 healthy control participants. Biochemical parameters and cardiac markers were estimated. Comparative utilities were assessed through logistic regression and receiver operating characteristic (ROC) analyses...
December 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29285132/effects-of-dexmedetomidine-on-h-fabp-ck-mb-ctni-levels-neurological-function-and-near-term-prognosis-in-patients-undergoing-heart-valve-replacement
#10
Zhi Wang, Qiang Chen, Hao Guo, Zhishan Li, Jinfeng Zhang, Lei Lv, Yongqing Guo
This study investigated the effects of dexmedetomidine on heart-type fatty acid binding protein (H-FABP), creatine kinase isoenzymes (CK-MB), and troponin I (cTnI) levels, neurological function and near-term prognosis in patients undergoing heart valve replacement. Patients undergoing heart valve replacement were randomly allocated to remifentanil anesthesia (control group, n=48) or dexmedetomidine anesthesia (observation group, n=48). Hemodynamic parameters were measured before anesthesia induction (T1), 1 min after intubation (T2), 10 min after start of surgery (T3), and on completion of surgery (T4)...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284896/neutrophil-to-lymphocyte-ratio-and-its-relation-with-markers-of-inflammation-and-myocardial-necrosis-in-patients-with-acute-coronary-syndrome
#11
Ema Tahto, Radivoj Jadric, Lamija Pojskic, Esmeralda Kicic
Introduction: Inflammation plays an important role in atherosclerosis which is the primary cause of acute coronary syndrome (ACS) that encompasses acute myocardial infarction (AMI) and unstable angina (UA). Objective: To investigate and characterize white blood cells (WBC) count, differential blood count in peripheral blood and neutrophil to lymphocyte ratio (NLR) in patients by the type of ACS. Patients and methods: The cross-sectional study included 100 patients with ACS (50 males, 50 females), aged 41 to 91 years, classified into two groups: AMI group (n=50) and UA group (n=50)...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29284532/abnormal-elevation-of-myocardial-necrosis-biomarkers-after-coronary-artery-bypass-grafting-without-established-myocardial-infarction-assessed-by-cardiac-magnetic-resonance
#12
Fernando Teiichi Costa Oikawa, Whady Hueb, Cesar Higa Nomura, Alexandre Ciappina Hueb, Alexandre Volney Villa, Leandro Menezes Alves da Costa, Rodrigo Morel Vieira de Melo, Paulo Cury Rezende, Carlos Alexandre Wainrober Segre, Cibele Larrosa Garzillo, Eduardo Gomes Lima, Jose Antonio Franchini Ramires, Roberto Kalil Filho
BACKGROUND: The diagnosis of peri-procedural myocardial infarction is complex, especially after the emergence of high-sensitivity markers of myocardial necrosis. METHODS: In this study, patients with normal baseline cardiac biomarkers and formal indication for elective on-pump coronary bypass surgery were evaluated. Electrocardiograms, cardiac biomarkers, and cardiac magnetic resonance imaging with late gadolinium enhancement were performed before and after procedures...
December 29, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29275611/-study-on-changes-of-calpain-and-myocardial-damage-in-rats-with-burn-blast-combined-injury
#13
F Xie, J K Chai, Q Hu, Y H Yu, H F Zhai, H Y Chou, S S Kang
Objective: To study myocardial damage and rules of calpain change in rats with burn-blast combined injury. Methods: One hundred and twenty-eight male SD rats were randomly divided into control group, burn group, blast group, burn-blast group, with 32 rats in each group. CONTROL GROUP: 37 degrees' warm water for 12 s; Burn group: 94 degrees' boiling water for 12 s; Blast group: 5 g cyclonite explode in 75 cm distance from left chest wall of rat; Burn-blast group: burn group and blast group combined modeling method...
December 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29274587/cardioprotective-effects-of-total-flavonoids-from-jinhe-yangxin-prescription-by-activating-the-pi3k-akt-signaling-pathway-in-myocardial-ischemia-injury
#14
Yangang Cheng, Jinyan Tan, Huifeng Li, Xiangpeng Kong, Yan Liu, Rui Guo, Guoyan Li, Bingyou Yang, Miaorong Pei
The purpose of the present study was to investigate the cardioprotective effects of total flavonoids of Jinhe yangxin prescription (JHTF) on myocardial ischemia (MI) injury rats induced by Isoproterenol (ISO) and explore the potential mechanisms underlying these effects. 128 male rats were randomized into 8 groups: Control, Model, Positive, JHTF-H (2.64 g/kg/d), JHTF-M (1.32 g/kg/day), JHTF-L (0.66 g/kg/d), LY + JHTF (JHTF-H plus LY294002, an inhibitor of PI3K/Akt) and LY groups. Electrocardiogram, histopathological examination and terminal deoxynucleotidyl transferase dUTP nickend labeling (TUNEL) assay were performed...
December 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29250545/efficacy-and-mechanism-of-preoperative-simvastatin-therapy-on-myocardial-protection-after-extracorporeal-circulation
#15
Ping Hua, Jianyang Liu, Jun Tao, Rongjun Zou, Xifeng Lin, Dingwen Zhang, Songran Yang
Background: Cardiopulmonary bypass (CPB) causes systemic inflammatory response and ischemia-reperfusion (IR) injury. Objective: To investigate the effect and mechanism of simvastatin on myocardial injury in cardiac valve surgery with CPB. Methods: One hundred thirty patients were randomly assigned to the statin group (n = 65) or control group (n = 65). Simvastatin was administered preoperatively and postoperatively. Duration of intensive care unit stay, duration of assisted ventilation, and left ventricular ejection fraction were recorded...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29244161/the-impact-of-coronary-anomalies-on-the-outcome-in-aortic-valve-surgery-comparison-of-bicuspid-aortic-valve-versus-tricuspid-aortic-valve-morphotype
#16
Shiho Naito, Johannes Petersen, Hermann Reichenspurner, Evaldas Girdauskas
OBJECTIVES: The association of anomalous anatomy of coronary arteries and bicuspid aortic valve (BAV) has been sporadically reported. Our aim was to evaluate the prevalence of coronary anomalies between BAV and tricuspid aortic valve (TAV) and to analyse their impact on major adverse cardiac events during and after aortic valve surgery. METHODS: A total of 1099 consecutive patients who received preoperative coronary evaluation and elective aortic valve replacement/repair between January 2013 and July 2016 at our institution were involved...
December 12, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29236093/trends-in-troponin-only-testing-for-ami-in-academic-teaching-hospitals-and-the-impact-of-choosing-wisely%C3%A2
#17
Micah T Prochaska, Samuel F Hohmann, Matthew Modes, Vineet M Arora
BACKGROUND: Identifying hospitals that are both early and consistent adopters of high-value care can help shed light on the culture and practices at those institutions that are necessary to promote high-value care nationwide. The use of troponin to diagnose acute myocardial infarction (AMI), and not to test for myoglobin or creatine kinase-MB (CK-MB), is a high-value recommendation of the Choosing Wisely® campaign. OBJECTIVE: To examine the variation in cardiac biomarker testing and the effect of the Choosing Wisely® troponin-only recommendation for the diagnosis of AMI...
December 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29227823/lncrna-malat1-regulates-sepsis-induced-cardiac-inflammation-and-dysfunction-via-interaction-with-mir-125b-and-p38-mapk-nf%C3%AE%C2%BAb
#18
Hu Chen, Xiaoyun Wang, Xuetao Yan, Xiaoli Cheng, Xianghu He, Wenzhong Zheng
This study aimed to explore the role of MALAT1 in sepsis-induced cardiac inflammation and dysfunction. We constructed the rat sepsis models through cecal ligation and puncture (CLP). The cardiac function, including left ventricular peak pressure (LVPP), left ventricular end diastolic pressure (LVEDP) and maximum rate of rise/fall of left ventricle pressure (±dp/dtmax) as well as the contents of serum cardiac troponin I (CTn-I), creatine kinase (CK), and creative kinase isoenzyme MB (CK-MB) were detected after modeling...
December 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29225152/a-randomized-controlled-trial-of-intra-aortic-adenosine-infusion-before-release-of-the-aortic-cross-clamp-during-coronary-artery-bypass-surgery
#19
Amany Ammar, Khaled Mahmoud, Ahmed Elkersh, Zeinab Kasemy
OBJECTIVES: To assess the feasibility, safety, and potential useful effect of adenosine as a postconditioning agent in patients undergoing coronary artery bypass grafting surgeries. DESIGN: Prospective randomized controlled study. SETTING: University hospital. PARTICIPANTS: The study comprised 60 patients scheduled for coronary artery bypass grafting surgery. INTERVENTIONS: Adenosine (postconditioning group) or placebo (control group)...
December 7, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29217241/myocardial-protection-in-mitral-valve-surgery-comparison-between-minimally-invasive-approach-and-standard-sternotomy
#20
Jean-Sébastien Lebon, Pierre Couture, Annik Fortier, Antoine G Rochon, Christian Ayoub, Claudia Viens, Éric Laliberté, Denis Bouchard, Michel Pellerin, Alain Deschamps
OBJECTIVE: To compare antegrade and retrograde cardioplegia administration in minimally invasive mitral valve surgery (MIMS) and open mitral valve surgery (OMS) for myocardial protection. DESIGN: Retrospective study. SETTING: Tertiary care university hospital. PARTICIPANTS: The study comprised 118 patients undergoing MIMS and 118 patients undergoing OMS. INTERVENTIONS: The data of patients admitted for MIMS from 2006 to 2010 were reviewed...
August 30, 2017: Journal of Cardiothoracic and Vascular Anesthesia
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