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https://www.readbyqxmd.com/read/27895451/non-cardiogenic-pulmonary-edema-rhabdomyolysis-and-myocardial-injury-following-heroin-inhalation-a-case-report
#1
G Bazoukis, A Spiliopoulou, K Mourouzis, P Grigoropoulou, A Yalouris
BACKGROUND: Heroin use by non-injecting routes of administration (snorting, swallowing, "chasing the dragon") is considered to be safer but is not risk-free for fatal overdose or serious side effects. We report the case of an adolescent who was transferred unconscious to the emergency department after heroin inhalation. Description of the case: A 17-year-old male was transferred to the emergency department unconscious (Glasgow coma scale: 6/15) after heroin inhalation. He was treated with non-rebreather mask and intravenous infusion of naloxone with gradual improvement of consciousness and arterial blood gasses...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27894261/multimarker-approach-for-the-prediction-of-microvascular-obstruction-after-acute-st-segment-elevation-myocardial-infarction-a-prospective-observational-study
#2
Hans-Josef Feistritzer, Sebastian Johannes Reinstadler, Gert Klug, Martin Reindl, Sebastian Wöhrer, Christoph Brenner, Agnes Mayr, Johannes Mair, Bernhard Metzler
BACKGROUND: Presence of microvascular obstruction (MVO) derived from cardiac magnetic resonance (CMR) imaging is among the strongest outcome predictors after ST-segment elevation myocardial infarction (STEMI). We aimed to investigate the comparative predictive values of different biomarkers for the occurrence of MVO in a large cohort of reperfused STEMI patients. METHODS: This study included 128 STEMI patients. CMR imaging was performed within the first week after infarction to assess infarct characteristics, including MVO...
November 28, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27873501/a-comparison-of-peri-procedural-myocardial-infarction-between-paclitaxel-coated-balloon-and-drug-eluting-stent-on-de-novo-coronary-lesions
#3
Ae Young Her, Kyoung Im Cho, Gillian Balbir Singh, Scot Garg, Yong Hoon Kim, Bon Kwon Koo, Eun Seok Shin
PURPOSE: This study compared the impact of paclitaxel-coated balloons (PCB) or drug eluting stents (DES) on peri-procedural myocardial infarction (PMI) on de novo coronary lesion in stable patients. MATERIALS AND METHODS: In this observational study, we compared the incidence of PMI amongst patients with single vessel de novo coronary lesions who underwent treatment with a PCB or DES. Propensity score-matching analysis was used to assemble a cohort of patients with similar baseline characteristics...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27869245/predictors-of-early-return-to-work-after-a-coronary-artery-bypass-graft-surgery-cabg
#4
Ramin Mehrdad, Noroja Ghadiri Asli, Gholamreza Pouryaghoub, Maryam Saraei, Firoozeh Salimi, Mostafa Nejatian
OBJECTIVES: Identifying factors predictive of early return to work in patients who underwent a coronary artery bypass graft surgery (CABG). MATERIAL AND METHODS: Two hundred twenty-six working patients who volunteered and underwent a primary coronary artery bypass surgery between September 2013 and May 2014 were selected for the study and followed up for 6 months. Predictors of early return to work (RTW) (within 2 months) were analyzed from variables in a prospectively collected database and the 36-Item Short Form Health Survey (SF-36) questionnaire carried out in the hospital and rehabilitation center as well as from the follow-up performed via the phone...
November 18, 2016: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/27866054/comparison-of-mirna-signature-versus-conventional-biomarkers-before-and-after-off-pump-coronary-artery-bypass-graft
#5
Fatemeh Pourrajab, Fereshteh Torkian Velashani, Masoud Khanaghaei, Seyedhossein Hekmatimoghaddam, Mahdi Rahaie, Mohamad Reza Zare-Khormizi
Circulating levels of microRNAs (miRNAs) and their expression patterns are supposed to serve as signatures for diagnosis or prognosis of cardiovascular events. The present study aimed at determining if there is any correlation between the release pattern of 2 miRNAs and the plasma levels of conventional biomarkers cardiac troponin I (cTnI), creatine kinase (CK) and uric acid (UA) in patients undergoing their first off-pump coronary artery bypass graft (OCABG). Seventy OCABG patients (69% men, aged 59.2±8.2years) were enrolled...
November 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27864741/an-ultrasensitive-label-free-nanobiosensor-platform-for-the-detection-of-cardiac-biomarkers
#6
Durga Prakash Matta, Suryasnata Tripathy, Siva Rama Krishna Vanjari, Chandra Shekhar Sharma, Shiv Govind Singh
We report the fabrication of a label free nano biosensor platform comprising single nanofiber that is derived out of multi-walled carbon nanotubes (MWCNTs) embedded SU-8 photoresist, for the detection of three important human cardiac biomarkers viz., myoglobin (Myo), cardiac Troponin I (cTn I) and Creatine Kinase-MB (CK-MB). These composite nanofibers were synthesized using electrospinning process. Single nanofibers were aligned between pairs of electrodes in-situ during the electrospinning process. The target proteins were detected using chemiresistive detection methodology...
December 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27861339/elevated-preoperative-hmgb1-as-predictor-of-myocardial-injury-post-percutaneous-coronary-intervention
#7
Peng Jin, Qi Zhou, Shujiang Song, Jinpeng Xu, Minli Zhang, Ming Zhu, Meili Kang, Xiangming Shi, Junting Shi, Di Lu, Jing Li
In this study, we evaluated the impact of preoperative high mobility group box 1 (HMGB1) on myocardial injury post-percutaneous coronary intervention.We evaluated 302 consecutive patients who underwent percutaneous coronary intervention. They were divided into equal tertiles based on their preoperative HMGB1 levels. Creatine kinase-MB and troponin I levels were measured at baseline, 8- and 24-hours after the procedure, while clinical outcomes were followed up for 1 year.The occurrence of post-procedural myocardial injury was significantly higher in the tertile comprising of patients with elevated HMGB1 levels...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27859888/changes-in-left-atrial-transport-function-in-patients-who-maintained-sinus-rhythm-after-successful-radiofrequency-catheter-ablation-for-atrial-fibrillation-a-1-year-follow-up-multi-slice-computed-tomography-study
#8
Jin-Seok Kim, Sung Il Im, Seung Yong Shin, Jun Hyuk Kang, Jin Oh Na, Cheol Ung Choi, Seong Hwan Kim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Chun Hwang, Young-Hoon Kim, Hwan Seok Yong, Hong Euy Lim
BACKGROUND: Functional remodeling of left atrium (LA) after radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) has not been fully elucidated. This study aimed to determine the impact of RFCA on LA transport function in patients who maintained sinus rhythm (SR) after AF ablation. METHODS AND RESULTS: A total of 96 patients [paroxysmal AF (PAF) = 52] who maintained SR during 1 year after AF ablation were enrolled. Multi-slice computed tomography was performed to determine LA volume (LAV) and LA emptying fraction (LAEF) at pre-RFCA and 1-year post-RFCA...
November 18, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27852589/effects-of-the-p-selectin-antagonist-inclacumab-on-myocardial-damage-after-percutaneous-coronary-intervention-according-to-timing-of-infusion-insights-from-the-select-acs-trial
#9
Barbara E Stähli, Catherine Gebhard, Valérie Duchatelle, Daniel Cournoyer, Thibaut Petroni, Jean-François Tanguay, Stephen Robb, Jessica Mann, Marie-Claude Guertin, R Scott Wright, Philippe L L'Allier, Jean-Claude Tardif
BACKGROUND: The Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention for Non-ST-Segment Elevation Myocardial Infarction (SELECT-ACS) trial suggested beneficial effects of inclacumab, a monoclonal antibody directed against P-selectin, on periprocedural myocardial damage. This study evaluated the effect of inclacumab on myocardial damage according to varying time intervals between study drug infusion and percutaneous coronary intervention (PCI)...
November 16, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27833481/cardiac-and-renal-protective-effects-of-dexmedetomidine-in-cardiac-surgeries-a-randomized-controlled-trial
#10
A S Ammar, K M Mahmoud, Z A Kasemy, M A Helwa
BACKGROUND: Cardiac and renal injuries are common insults after cardiac surgeries that contribute to perioperative morbidity and mortality. Dexmedetomidine has been shown to protect several organs against ischemia/reperfusion-(I/R) induced injury. We performed a randomized controlled trial to assess the effect of dexmedetomidine on cardiac and renal I/R injury in patients undergoing cardiac surgeries. MATERIALS AND METHODS: Fifty patients scheduled for elective cardiac surgeries were randomized to dexmedetomidine group that received a continuous infusion of dexmedetomidine initiated 5 min before cardiopulmonary bypass (1 μg/kg over 15 min, followed by 0...
October 2016: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/27813551/rehmannia-glutinosa-oligosaccharide-induces-differentiation-of-bone-marrow-mesenchymal-stem-cells-into-cardiomyocyte-like-cells
#11
X H Wang, H W Du, X H Guo, S W Wang, R B Zhou, Y Li, Z B Li, Y S Zhao, Q L Zhu
The aim of this study was to observe the effect of Rehmannia glutinosa oligosaccharide (RGO) on differentiation of bone marrow mesenchymal stem cells (MSCs) into cardiomyocyte-like cells . Rat MSCs were isolated, treated, and grouped as follows: RGO treatment group, 5-azacytidine (5-aza) treatment group, RGO + 5-aza treatment group, and control group. Following a four-week induction period, cardiac troponin I (cTnI) levels in MSCs were quantified by chemiluminescence, and the levels of myocardial enzymes creatine kinase (CK) and creatine kinase isoenzyme-MB (CK-MB) were measured using a dry chemistry analyzer...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27807326/-protective-effect-of-right-coronary-artery-ischemic-preconditioning-on-myocardial-ischemia-reperfusion-injury-%C3%A2-in-rabbit-heart
#12
Jun Li, Guoqiang Lin, Rimao Huang, Huihui Lu, Zhong Yang, Wanjun Luo
To explore the protective effects of right coronary artery ischemic preconditioning and post-conditioning on myocardial ischemia reperfusion injury in rabbit heart.
 Methods: A total of 30 rabbits were randomly divided into 4 groups: a control group (n=7), an ischemia reperfusion group (IR group, n=8), an ischemic preconditioning group (IPC group, n=8) and an ischemic post-conditioning group (IPO group, n=7). Venous blood samples were taken at pre-operation, 1 and 6 h post-operation, and the concentration of serum creatine kinase isoenzyme (CK-MB) and cardiac troponin-T (cTn-T) were measured...
October 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27803423/differential-expression-of-cardiac-troponin-t-and-i-in-a-patient-with-isolated-skeletal-muscular-sarcoidosis
#13
Hiroshi Mannoji, Fumie Hayashi, Toru Kubota, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Seiya Kato, Nobuhiro Tahara, Takayoshi Fukutomi, Takeshi Yamada, Masanori Okabe, Yusuke Yamamoto
A 49-year-old female was referred to our hospital due to high serum creatine kinase (CK) (2,605 IU/L) and serum cardiac troponin T (cTnT) (0.342 ng/mL) levels. She had no other complaints and further examinations suggested no signs of cardiac disease. Additionally, the serum cardiac troponin I (cTnI) levels were normal. She reported having gradually felt difficulty in walking upstairs. A biopsy indicated skeletal muscle sarcoidosis with positive staining for cTnT. Steroid therapy immediately resolved her muscular symptoms with a normalization of the serum CK levels...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27796666/effects-of-remote-ischemic-preconditioning-on-acute-myocardial-injury-in-patients-undergoing-valve-replacement
#14
Z Cao, R Shen, X Zhang, G Cheng, Z Yan
BACKGROUND: This study investigated the effects of remote ischemic preconditioning (RIPC) on acute myocardial injury and clinical outcome in adult patients undergoing valve replacement surgery. METHODS: Sixty-three adult patients scheduled for elective valve replacement undergoing cardiopulmonary bypass (CPB) were randomly assigned to control or remote ischemic preconditioning treatment. RIPC was applied beginning with the first surgical incision by three times of inflating the cuff to 200 mmHg for 5 min, followed by 5 min of deflation...
October 31, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27777517/detecting-acute-myocardial-infarction-by-diffusion-weighted-versus-t2-weighted-imaging-and-myocardial-necrosis-markers
#15
Jiyang Jin, Min Chen, Yongjun Li, YaLing Wang, Shijun Zhang, Zhen Wang, Lin Wang, Shenghong Ju
We used a porcine model of acute myocardial infarction to study the signal evolution of ischemic myocardium on diffusion-weighted magnetic resonance images (DWI). Eight Chinese miniature pigs underwent percutaneous left anterior descending or left circumflex coronary artery occlusion for 90 minutes followed by reperfusion, which induced acute myocardial infarction. We used DWI preprocedurally and hourly for 4 hours postprocedurally. We acquired turbo inversion recovery magnitude T2-weighted images (TIRM T2WI) and late gadolinium enhancement images from the DWI slices...
October 2016: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/27773717/cardioprotective-effects-of-monocyte-locomotion-inhibitory-factor-on-myocardial-ischemic-injury-by-targeting-vimentin
#16
Shu Jiang, Yulan Liu, Jing Wang, Yue Zhang, Yaocheng Rui, Yuefan Zhang, Tiejun Li
Monocyte locomotion inhibitory factor (MLIF), a heat-stable pentapeptide produced by Entamoeba histolytica, has anti-inflammatory function and protective effect on ischemic stroke. In this study, we evaluated the effect of MLIF on myocardial ischemia. The myocardial ischemia reperfusion (I/R) model was established by ligation of the left anterior descending branch (LAD) using 8-0 silk suture for 30min followed by 3h reperfusion in mice. After sacrifice, the serum concentrations of cardiac troponin I (cTnI), creatine kinase (CK), lactate dehydrogenase (LDH) as well as the heart infarct size were measured...
October 20, 2016: Life Sciences
https://www.readbyqxmd.com/read/27770663/low-protein-z-plasma-level-is-a-risk-factor-for-acute-myocardial-infarction-in-coronary-atherosclerosis-disease-patients
#17
Baoxin Liu, Yong Li, Jiachen Luo, Liming Dai, Jinlong Zhao, Hongqiang Li, Qiqiang Jie, Dongzhi Wang, Xin Huang, Yidong Wei
OBJECTIVES: To examine plasma protein Z (PZ) levels in acute myocardial infarction (AMI) and chronic coronary atherosclerosis disease (CCAD) patients without history of AMI and explore its potential clinical significance. METHODS: Plasma PZ concentrations were measured in 90 AMI patients (Group A), 87 CCAD patients without AMI history who remained free of major clinical events at least one year (Group B), and 88 clinically healthy controls (Group C). RESULTS: PZ was found to be significantly lower (P<0...
October 13, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27760066/the-impact-of-allopurinol-on-patients-with-acute-st-elevation-myocardial-infarction-undergoing-thrombolytic-therapy
#18
Ahmad Separham, Samad Ghaffari, Hossein Najafi, Reza Ghaffari, Mojtaba Ziaee, Hossein Babaei
Allopurinol may have protective effects over ischemic reperfusion injury and reduce infarct size. In this randomized study, we aimed to evaluate the impact of allopurinol in patients with acute ST elevation myocardial infarction (STEMI) undergoing thrombolytic therapy. Overall, 140 patients with STEMI were randomly assigned to receive 400 mg of allopurinol or placebo before treating with streptokinase. Then, study group received 100 mg of allopurinol daily for 28 days and placebo group received placebo for the same period...
October 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27747690/stemi-secondary-to-coronary-vasospasm-possible-adverse-event-of-methylphenidate-in-a-21-year-old-man-with-adhd
#19
Timo-Benjamin Baumeister, Ingo Wickenbrock, Christian A Perings
Methylphenidate (Ritalin(®)) is an increasingly used medication in the treatment of attention-deficit hyperactivity disorder (ADHD). Cardiovascular adverse effects like vasospasm or myocardial infarction are described as very rare adverse effects. We present the case of a 21-year-old man diagnosed with ADHD who recently started therapy with Ritalin(®) Adult 20 mg for at least 3 days. Afterwards he presented with chest pain, elevated troponin and creatine kinase, and posterolateral ST elevations. A myocarditis was initially supposed...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27735797/sinus-tachycardia-related-to-tacrolimus-after-kidney-transplantation-in-children-and-young-adults
#20
İlkay Erdoğan, Yelda Bilginer, Ali Düzova, Nesrin Beşbaş
Tacrolimus is a potent immunosuppressive agent widely used after organ transplantation. In this present study we present eight patients who complained of palpitation after kidney transplantation. Eight out of 31 patients who received tacrolimus after kidney transplantation suffered from tachycardia. Resting electrocardiography, 24 hours Holter monitorization, echocardiography were performed, and serum levels of cardiac troponin T, creatine kinase, CKMB, brain natriuretic peptide and tacrolimus were measured...
November 2015: Turkish Journal of Pediatrics
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