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Yuxiang Song, Feng Chen, Jiang Xiong, Wei Guo, Xiujie Pan, Senhao Jia, Jie Liu
OBJECTIVE: By observation of the diameter, progression rate, wall thickness, and the opening angle of the abnormal aortic of abdominal aortic aneurysm (AAA) in rats, to observe the effect of saturated hydrogen saline on residual strain of AAA rats, and to investigate its inhibition effect on AAA formation. METHODS: Twenty healthy male Sprague Dawley rats (weighing, 200-220 g) were randomly divided into 2 groups, which was made the AAA model by infiltration of the abdominal arota with 0...
July 2013: Chinese Journal of Reparative and Reconstructive Surgery
Feng Chen, Jiang Xiong, Wei Guo, Xiu-jie Pan, Tao Zhang, Yu-xiang Song, Sen-hao Jia, Jie Liu
OBJECTIVE: To investigate the effects of saturated hydrogen saline on the prevention of abdominal aortic aneurysm (AAA) induced by calcium chloride in a rat model. METHODS: In healthy male Sprague-Dawley rats, AAA was induced by infiltration of abdominal arota with 0.5 mol/L calcium chloride. Saturated hydrogen saline (5 ml·kg(-1)·d(-1)) or saline was administred intraperitoneally once daily. Twenty-eight days later, the diameter of the aorta was measured, and the aortic tissue was exercised for histological examination...
May 1, 2013: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Hua Zhong, Qing-Hua Hu, En-Bang Wang, Jun-Qiang Si, Zhi-Ping Sun, Zeng-Chun Li, Fang He
OBJECTIVE: To investigate whether homocysteine (Hcy) participates the proliferation of the spontaneously hypertensive rat(SHR) vascular smooth muscle cell (VSMCs) and the molecular mechanism. METHODS: The rat's arota were removed. The primary SHR VSMCs were isolated and cultured in vitro, then the SHR VSMCs were divided into four groups: (1) control group, (2) Hcy group, (3) 18alpha-glycyrrhetinic acid (GA) group, (4) Hcy + 18alpha-GA group. We detected proliferation of the SHR VSMCs by MTT and flow cytometry...
July 2012: Chinese Journal of Applied Physiology
Min Xiang, Jianmei Wang, Yaqin Zhang, Jing Ling, Xiaoyue Xu
Vascular complications are the leading causes of morbidity and mortality in diabetes mellitus (DM). The RAGE (receptor for advanced glycation end products)-NADPH oxidase-NF-κB signal transduction pathway plays an important role in the development of oxidative stress-related vascular complications in DM. Ursolic acid (UA), a pentacyclic triterpenoid derived from plants, has been reported to have multiple pharmacological effects, including a potent antioxidant activity. This study aimed to investigate both the effect of UA on aortic injury in streptozotocin (STZ)-induced diabetic rats and the drug's mechanism of action...
May 2012: Archives of Pharmacal Research
Hua Zhong, Fang He, Qin-hua Hu, Zhen-huan Wang, Feng-mei Deng, Zhi-ping Sun, Zeng-chun Li
OBJECTIVE: To investigate if the interaction between TGF-beta1/Smad pathway and ERK pathway in vascular smooth muscle cells exists. METHODS: The rat arota was removed. The primary VSMC were isolated and cultured in vitro, then the VSMC were divided into four groups: (1) control group, (2) (TGF-beta1 group, (3) ERK blocking agent group, (4) TGF-beta1 + ERK blocking agent group. The expression of Smad2/3, ERK1/2 proteins, the content of phosphorylated ERK1/2 and Smad2/3 proteins were detected by Western blot, and the expression of Smad2/3 mRNA was detected by reverse transcription-polymerase chain reaction(RT-PCR) ...
February 2010: Chinese Journal of Applied Physiology
Li-hong Fan, Hong-yan Tian, Ai-qun Ma, Zhi Hu, Jian-hua Huo, Yong-xiao Cao
AIM: To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. METHODS: Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, K(ATP) channelmediated relaxation responses in the aortas and mesenteric arteries, K(ATP) channel current, and gene expression were examined, respectively...
October 2008: Acta Pharmacologica Sinica
D Du, S Chang, B Chen, H Zhou, Z K Chen
PURPOSE: Heme oxygenase-1 (HO-1) has been implicated in graft protection because its induction is associated with long-surviving allografts. The aim of this study was to analyze the efficacy of adenovirus-mediated HO-1 overexpression to inhibit graft arteriosclerosis and estimate whether the protective role correlated with nuclear factor kappaB (NF=kappaB) expression and grafts apoptosis. METHODS: Aortic transplantation was performed using inbred Brown-Norway (BN) rats (RT1n male) as donors and Lewis rats (RT1l male) as recipients...
December 2007: Transplantation Proceedings
Ruyi Luo, Yu Zhang, Ling Xia
The goal of our research is try to explain the electrophysiological mechanisms of alternation in T-wave of ECG in ultrahigh static magnetic field (SMF). The magneto-hydrodynamics model study shows that ultrahigh SMF can induce reduction in the volume flow rate of the blood in human arota more than 10%, thus may lead to anoxia condition of acute ischemia. Using an ionic-based theoretical model of the cardiac ventricular cell, we simulate transmural heterogeneous suppression of the action potential plateau and action potential duration shortening in case of different anoxia degree...
2005: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
María Jesús Perez-Elias, Isabel Garcia-Arota, Vicente Muñoz, Ignacio Santos, José Sanz, Victor Abraira, José R Arribas, Juan González, Ana Moreno, Fernando Dronda, Antonio Antela, María Pumares, Paloma Martí-Belda, Jose L Casado, Paloma Geijos, Santiago Moreno et al.
BACKGROUND: Resistance testing is useful in the management of virological failure patients, although the best method to be used in clinical practice has not been determined. METHODS: A prospective, randomized, double-blind, multicentre, controlled clinical trial was performed to compare the usefulness of drug resistance testing with a recombinant viral phenotype method or with a virtual phenotype, a genotyping interpretation system. Planned 300 HIV-infected adults failing their current antiretroviral therapy (HIV RNA > 1000 copies/ml) were centrally randomized 1:1 to resistance testing with a recombinant viral phenotype method or with a virtual phenotype, after stratifying according to previous drug exposure (one or two versus three drug classes)...
December 2003: Antiviral Therapy
C Hou, Q He, S Li
OBJECTIVE: To examine the preventive effect of Buyang Huanwu Decoction (BYHWD) on imitative restenosis after percutaneous transluminal coronary angioplasty (PTCA) in diet-induced atherosclerotic rabbits. METHODS: Diet-induced atherosclerotic rabbits were randomly allocated into group 1 (n = 24, fed with BYHWD one week before and 4 weeks after the operation, 2 ml/kg per day, containing herbal drug 8.4 g/ml) and group 2 (n = 20, as control). Balloon angioplasty was performed in the abdominal arota to mimic coronary angioplasty...
May 2001: Chinese Journal of Integrated Traditional and Western Medicine
P V Sharma, S C Babu, P M Shah, Z E Nassoura
Among 1011 patients undergoing infrarenal aortic and infrainguinal vascular surgery in a 90-month period (1986-1993), 29 patients (2.9%) with clinical, angiographic and pathologic evidence of atheroembolism were identified. Over one-third (44.8%) of atheroemboli were iatrogenic and the rest spontaneous. All iatrogenic atheroemboli were precipitated by angiographic (n = 11; 84.6%) or operative manipulation (n = 2; 15.4%). The sources of emboli were in the abdominal arota (16), iliac (seven) and femoropopliteal (six) arteries...
October 1996: Cardiovascular Surgery: Official Journal of the International Society for Cardiovascular Surgery
B Pereira, K K Wu, L H Wang
The cDNA encoding prostacyclin synthase (PGIS) was isolated from a bovine arota cDNA library. The cDNA contained an open reading frame of 1500 nucleotides encoding a polypeptide of 500 amino acids with a Mr of 56,675. The predicted amino acid sequence contains four polypeptide sequences determined from purified bovine PGIS. Comparison of the PGIS sequence with other protein sequences in protein data banks indicates that PGIS has considerable sequence similarity with cytochrome P450s; the closest related sequence is that of human cholesterol 7-alpha-monooxygenase (CYP 7)...
August 30, 1994: Biochemical and Biophysical Research Communications
M P Goldsman, A Pedram, C E Dominguez, I Ciuffardi, E Levin, R H Asch
OBJECTIVE: To examine the effect of follicular fluid (FF) and peritoneal fluid (PF) from patients undergoing assisted reproductive technology procedures on endothelial barrier function. This was determined in vitro by measuring the permeability of filter-grown bovine aortic endothelial cell monolayers to a permeability marker. DESIGN: Endothelial cells obtained from bovine thoracic arotas were treated with collagenase solution and plated on millicell filters, on which they formed confluent monolayers...
February 1995: Fertility and Sterility
M T Subbiah, E Schweiger, D Deitmeyer, L Gallon, H Sinzinger
The aortas of 9 months aged Show Racer and White Carneau pigeons were examined for their PGE2, PGF2 alpha and 6-keto-PGF1 alpha synthesis from labelled arachidonic acid by radiothinlayer chromatography. The prostacyclin formation was estimated by means of Moncada's bioassay. PGE2 and PGF 2 alpha synthesis in the aorta of pigeons is higher than in rats, whereas less 6-keto-PGF1 alpha is formed in pigeon aortas. The susceptible White Carneau pigeons synthesitize more prostaglandins than the resistant Show Racer pigeons...
1980: Artery
M Toscano, R Chiavarelli, B Marino
A survey of the literature on coren. Operative mortality was reduced from 39% (1960 through 1970) to 26% (1971 through 1978). It was higher in patients operated on during the first three months of life and in those with associated cardiac lesions. The incidence rate of restenosis has diminished from 27% to 4% by using the aortoplasty with a subclavian flap. Since the natural and the "innatural" history emphasize the importance of early diagnosis and treatment for patients with coarctation of the aorta, these recent results suggest that the optimal time for elective surgical correction is around the age of one year, and that the subclavian flap procedure is the technique of choice at this age...
1980: Giornale Italiano di Cardiologia
C V Cimmino
No abstract text is available yet for this article.
January 1970: Radiology
E Strobl-Jäger, P Fitscha, J Kaliman, H Sinzinger, B A Peskar
Human plasma contains a factor capable of stimulating vascular prostacyclin generation even in atherosclerotic vessels with minimal in-vitro capacity for PGI2-synthesis. The activity of this prostacyclin stimulating plasma factor (PSPF) has been reported to be elevated in renal failure and hepatic coma. We are not aware of any data as to whether this PSPF plays a role in maintaining hemostatic balance in patients with peripheral vascular lesions. Therefore, we examined 62 patients with peripheral vascular disease (PVD)...
August 1987: Prostaglandins, Leukotrienes, and Medicine
G J Reul, D A Cooley, G L Hallman, S B Reddy, E R Kyger, D C Wukasch
Dissecting aneurysm of the descending thoraic aorta (type iii) is a specific disease process whose pathogenesis, pathologic description, surgical treatment, and prognosis is different from dissections of the ascending arota (types l and ll). From 1964 through 1974, 91 patients underwent surgical correction of type iii dissection. The operative mortality was 21% and late mortality, up to ten years follow-up, was 13%. During the past four years, operative mortality has dropped to 6.5%. Mortality was determined by extent of the aneurysm and underlying cardiac disease...
May 1975: Archives of Surgery
P V Moulder, B Flauto, B Gallet, S Galansky, J A Alexander
Analog pressure signals (catheter-tip manometers) from the left atrium, left ventricle, and aorta and a flow signal from the arota were obtained in 25, open-chest, anesthetized dogs in which 115 episodes of ischemia were produced in an area of the left ventricle subtended by the distal left anterior descending coronary artery and its last major diagonal branch. The left ventricular pressure and its first derivative (dP/dt) were displayed as an X-Y loop. The character of this loop went through a unique series of dynamic changes in 110 of the 115 ischemic episodes, indicating that this is a useful tool for monitoring myocardial ischemia...
January 1979: Surgery
I W Fong, C B Baker, D C McKee
Prospective and retrospective studies were performed to determine the efficacy of prophylactic antibiotics in preventing infections in patients undergoing arota-coronary bypass. One-hundred five patients were randomized in a double-blind fashion to receive either methicillin or saline-placebo for 3 days. The over-all infection rate was 26.7% with 48.9% in the control group and 8.6% in the methicillin group (p less than 0.001). Significant sternal wound infection developed in 21.3% of the control group and 0% of the methicillin group (p less than 0...
December 1979: Journal of Thoracic and Cardiovascular Surgery
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