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https://www.readbyqxmd.com/read/28910310/gugulipid-causes-hypercholesterolemia-leading-to-endothelial-dysfunction-increased-atherosclerosis-and-premature-death-by-ischemic-heart-disease-in-male-mice
#1
Andrea Leiva, Susana Contreras-Duarte, Ludwig Amigo, Esteban Sepúlveda, Mauricio Boric, Verónica Quiñones, Dolores Busso, Attilio Rigotti
For proper cholesterol metabolism, normal expression and function of scavenger receptor class B type I (SR-BI), a high-density lipoprotein (HDL) receptor, is required. Among the factors that regulate overall cholesterol homeostasis and HDL metabolism, the nuclear farnesoid X receptor plays an important role. Guggulsterone, a bioactive compound present in the natural product gugulipid, is an antagonist of this receptor. This natural product is widely used globally as a natural lipid-lowering agent, although its anti-atherogenic cardiovascular benefit in animal models or humans is unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28863273/2-3-4-5-tetrahydroxystilbene-2-0-%C3%AE-d-glycoside-attenuates-atherosclerosis-in-apolipoprotein-e-deficient-mice-role-of-reverse-cholesterol-transport
#2
Xuemeng Chen, Kun Tang, Yi Peng, Xiaole Xu
The aim of this study was to evaluate the potential effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) on atherosclerotic plaque development in ApoE-/- mice, and explore the mechanisms involved. Our data showed that after eight weeks treatment, TSG ameliorated serum levels of total cholesterol, triglyceride and low density lipoprotein cholesterol and increased serum level of high density lipoprotein cholesterol in ApoE-/- mice. TSG suppressed hepatic steatosis, atherosclerotic lesion formation and macrophage foam cell formation in ApoE-/- mice...
September 1, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28830907/plasma-cholesterol-homeostasis-hdl-remodeling-and-function-during-the-acute-phase-reaction
#3
Francesca Zimetti, Stefano De Vuono, Monica Gomaraschi, Maria Pia Adorni, Elda Favari, Nicoletta Ronda, Maria Anastasia Ricci, Fabrizio Veglia, Laura Calabresi, Graziana Lupattelli
Acute phase reaction (APR) is a systemic inflammation triggered by several conditions associated with lipid profile alterations. We evaluated whether APR also associates with changes in cholesterol synthesis and absorption, HDL structure, composition and cholesterol efflux capacity (CEC). We analyzed 59 subjects with APR related to infections, oncologic causes or autoimmune diseases and 39 controls. We detected no difference in markers of cholesterol synthesis and absorption. Conversely, a significant reduction of LpA-I- and LpAI:AII-containing HDL (-28% and -44...
August 22, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28830501/high-density-lipoproteins-suppress-a%C3%AE-induced-pbmc-adhesion-to-human-endothelial-cells-in-bioengineered-vessels-and-in-monoculture
#4
Jérôme Robert, Emily B Button, Sophie Stukas, Guilaine K Boyce, Ebrima Gibbs, Catherine M Cowan, Megan Gilmour, Wai Hang Cheng, Sonja K Soo, Brian Yuen, Arvin Bahrabadi, Kevin Kang, Iva Kulic, Gordon Francis, Neil Cashman, Cheryl L Wellington
BACKGROUND: Alzheimer's Disease (AD), characterized by accumulation of beta-amyloid (Aβ) plaques in the brain, can be caused by age-related failures to clear Aβ from the brain through pathways that involve the cerebrovasculature. Vascular risk factors are known to increase AD risk, but less is known about potential protective factors. We hypothesize that high-density lipoproteins (HDL) may protect against AD, as HDL have vasoprotective properties that are well described for peripheral vessels...
August 22, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28828863/rerouting-native-hdl-to-predetermined-receptors-for-improved-tumor-targeted-gene-silencing-therapy
#5
Yang Ding, Yue Han, Ruoning Wang, Yazhe Wang, Cheng Chi, Ziqiang Zhao, Huaqing Zhang, Wei Wang, Lifang Yin, Jianping Zhou
High-density lipoprotein (HDL) is an outstanding biocompatible nanovector for tumor-targeted delivery of multimodel drugs in cancer therapy. However, this seemingly promising delivery platform demonstrates an adverse accumulation in liver and adrenal due to the primary expression of natural target scavenger receptor class B type I (SR-BI), which overexpressed in malignant cells as well. Therefore, we endowed native HDLs with rerouting capacity, that is, enabling HDLs to get away from natural receptors (SR-BI) to selectively alternate tumor-rich receptors...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28811710/single-amino-acid-mutation-of-sr-bi-decreases-infectivity-of-hepatitis-c-virus-derived-from-cell-culture-in-a-cell-culture-model
#6
Rong Gao, Wei Gao, Gang Xu, Jie Xu, Hao Ren
AIM: To investigate the effect of a single amino acid mutation in human class B scavenger receptor I (SR-BI) on the infectivity of cell culture-derived hepatitis C virus (HCVcc) in SR-BI knock-down Huh7-siSR-BI cells. METHODS: Site-directed mutagenesis was used to construct the SR-BI S112F mutation, and the mutation was confirmed by nucleotide sequencing. SR-BI knock-down Huh7-siSR-BI cells were transfected with SR-BI S112F, SR-BI wild type (WT) and control plasmids, and then infected with HCVpp (HCV pseudoparticles) and hepatitis C virus derived from cell culture (HCVcc)...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28766509/high-density-lipoprotein-metabolism-and-reverse-cholesterol-transport-strategies-for-raising-hdl-cholesterol
#7
Katerina Tosheska Trajkovska, Sonja Topuzovska
A key to effective treatment of cardiovascular disease is to understand the body's complex lipoprotein transport system. Reverse cholesterol transport (RCT) is the process of cholesterol movement from the extrahepatic tissues back to the liver. Lipoproteins containing apoA-I [highdensity lipoprotein (HDL)] are key mediators in RCT, whereas non-high-density lipoproteins (non-HDL, lipoproteins containing apoB) are involved in the lipid delivery pathway. HDL particles are heterogeneous; they differ in proportion of proteins and lipids, size, shape, and charge...
August 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28758667/reciprocal-upregulation-of-scavenger-receptors-complicates-interpretation-of-nanoparticle-uptake-in-non-phagocytic-cells
#8
Kanlaya Prapainop, Rong Miao, Christoffer Åberg, Anna Salvati, Kenneth A Dawson
Nanoparticles have great potential as drug delivery vehicles or as imaging agents for treatment and diagnosis of various diseases. It is therefore crucial to understand how nanoparticles are taken up by cells, both phagocytic and non-phagocytic. Small interference RNA has previously been used to isolate the effect of particular receptors in nanoparticle uptake by silencing their expression. Here we show that, when it comes to receptors with overlapping function, interpretation of such data has to be done with caution...
July 31, 2017: Nanoscale
https://www.readbyqxmd.com/read/28753317/natural-particulates-inspired-specific-targeted-codelivery-of-sirna-and-paclitaxel-for-collaborative-antitumor-therapy
#9
Ruoning Wang, Ziqiang Zhao, Yue Han, Shihao Hu, Yaw Opoku-Damoah, Jianping Zhou, Lifang Yin, Yang Ding
The effective combination of drugs promoting antiangiogenesis and apoptosis effects has proven to be a promising collaborative tumor antidote; and the codelivery of small interfering RNA (siRNA) and chemotherapy agents within one efficient vehicle has gained more attention over single regimen administration. Herein, vascular endothelial growth factor specific siRNA (siVEGF) and paclitaxel (PTX) were introduced as therapeutic companions and coencapsulated into naturally mimic high-density lipoproteins (rHDL/siVEGF-PTX), so that various mechanisms of treatment can occur simultaneously...
August 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28701710/deficient-vitamin-e-uptake-during-development-impairs-neural-tube-closure-in-mice-lacking-lipoprotein-receptor-sr-bi
#10
Nicolás Santander, Carlos Lizama, María José Parga, Alonso Quiroz, Druso Pérez, Guadalupe Echeverría, Lorena Ulloa, Verónica Palma, Attilio Rigotti, Dolores Busso
SR-BI is the main receptor for high density lipoproteins (HDL) and mediates the bidirectional transport of lipids, such as cholesterol and vitamin E, between these particles and cells. During early development, SR-BI is expressed in extraembryonic tissue, specifically in trophoblast giant cells in the parietal yolk sac. We previously showed that approximately 50% of SR-BI(-/-) embryos fail to close the anterior neural tube and develop exencephaly, a perinatal lethal condition. Here, we evaluated the role of SR-BI in embryonic vitamin E uptake during murine neural tube closure...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629534/heparin-derived-oligosaccharide-inhibits-vascular-intimal-hyperplasia-in-balloon-injured-carotid-artery
#11
Jie-Ru Liu, Jie Wu, Xin-Chao Yu, Xuan Qian, Rui Xiong, Hui-Fang Wang, Dan-Feng Yu, Fei-Fei Liu, Shu-Ying He
The aims of the present study were to determine the effects of heparin-derived oligosaccharides (HDOs) on vascular intimal hyperplasia (IH) in balloon-injured carotid artery and to elucidate the underlying mechanisms of action. An animal model was established by rubbing the endothelia within the common carotid artery (CCA) in male rabbits. The rabbits were fed a high-cholesterol diet. Arterial IH was determined by histopathological changes to the CCA. Serum lipids were detected using an automated biochemical analysis...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28611100/ampk-activation-enhances-the-anti-atherogenic-effects-of-high-density-lipoproteins-in-apoe-mice
#12
Ang Ma, Jing Wang, Liu Yang, Yuanyuan An, Haibo Zhu
HDL plays crucial roles at multiple stages of the pathogenesis of atherosclerosis. AMP-activated protein kinase (AMPK) is a therapeutic candidate for the treatment of cardiovascular disease. However, the effect of AMPK activation on HDL functionality has not been established in vivo. We assessed the effects of pharmacological AMPK activation using A-769662, AICAR, metformin, and IMM-H007 on the atheroprotective functions of HDL in apoE-deficient (apoE(-/-)) mice fed with a high-fat diet. After administration, there were no changes in serum lipid levels among the groups...
August 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28552715/influence-of-scarb1-gene-snps-on-serum-lipid-levels-and-susceptibility-to-coronary-heart-disease-and-cerebral-infarction-in-a-chinese-population
#13
Ting-Ting Zeng, Di-Jiao Tang, Yuan-Xin Ye, Jun Su, Hong Jiang
The SCARB1 gene encodes human scavenger receptor class B type I (SR-BI), the primary receptor for high-density lipoprotein (HDL)- cholesteryl ester uptake, and polymorphisms in this gene may influence SR-BI protein expression and serum lipid levels, modulating susceptibility to coronary heart disease (CHD) and cerebral infarction (CI). Therefore, we investigated the association between singlenucleotide polymorphisms (SNPs) in the SCARB1 gene and serum lipid levels as well as risk of CHD and CI in the Chinese Han population...
August 30, 2017: Gene
https://www.readbyqxmd.com/read/28549616/pectin-penta-oligogalacturonide-reduces-cholesterol-accumulation-by-promoting-bile-acid-biosynthesis-and-excretion-in-high-cholesterol-fed-mice
#14
Ru-Gang Zhu, Yan-Di Sun, Yu-Ting Hou, Jun-Gang Fan, Gang Chen, Tuo-Ping Li
Haw pectin penta-oligogalacturonide (HPPS) has important role in improving cholesterol metabolism and promoting the conversion of cholesterol to bile acids (BA) in mice fed high-cholesterol diet (HCD). However, the mechanism is not clear. This study aims to investigate the effects of HPPS on cholesterol accumulation and the regulation of hepatic BA synthesis and transport in HCD-fed mice. Results showed that HPPS significantly decreased plasma and hepatic TC levels but increased plasma high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) levels, compared to HCD...
June 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28506360/plasmodium-p36-determines-host-cell-receptor-usage-during-sporozoite-invasion
#15
Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes...
May 16, 2017: ELife
https://www.readbyqxmd.com/read/28486435/regulated-entry-of-hepatitis-c-virus-into-hepatocytes
#16
REVIEW
Zhijiang Miao, Zhenrong Xie, Jing Miao, Jieyu Ran, Yue Feng, Xueshan Xia
Hepatitis C virus (HCV) is a model for the study of virus-host interaction and host cell responses to infection. Virus entry into hepatocytes is the first step in the HCV life cycle, and this process requires multiple receptors working together. The scavenger receptor class B type I (SR-BI) and claudin-1 (CLDN1), together with human cluster of differentiation (CD) 81 and occludin (OCLN), constitute the minimal set of HCV entry receptors. Nevertheless, HCV entry is a complex process involving multiple host signaling pathways that form a systematic regulatory network; this network is centrally controlled by upstream regulators epidermal growth factor receptor (EGFR) and transforming growth factor β receptor (TGFβ-R)...
May 9, 2017: Viruses
https://www.readbyqxmd.com/read/28434931/effect-of-size-and-pegylation-of-liposomes-and-peptide-based-synthetic-lipoproteins-on-tumor-targeting
#17
Jie Tang, Rui Kuai, Wenmin Yuan, Lindsey Drake, James J Moon, Anna Schwendeman
Synthetic high-density lipoprotein nanoparticles (sHDL) are a valuable class of nanomedicines with established animal safety profile, clinical tolerability and therapeutic efficacy for cardiovascular applications. In this study we examined how the scavenger receptor B-I-mediated (SR-BI) tumor-targeting ability of sHDL, long plasma circulation half-life, and small particle size (9.6±0.2nm) impacted sHDL accumulation in SR-BI positive colorectal carcinoma cells, 3D tumor spheroids, and in vivo xenografts. We compared tumor accumulation of sHDL with that of liposomes (LIP, 130...
August 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28423002/human-sr-bii-mediates-saa-uptake-and-contributes-to-saa-pro-inflammatory-signaling-in-vitro-and-in-vivo
#18
Irina N Baranova, Ana C P Souza, Alexander V Bocharov, Tatyana G Vishnyakova, Xuzhen Hu, Boris L Vaisman, Marcelo J Amar, Zhigang Chen, Alan T Remaley, Amy P Patterson, Peter S T Yuen, Robert A Star, Thomas L Eggerman
Serum amyloid A (SAA) is an acute phase protein with cytokine-like and chemotactic properties, that is markedly up-regulated during various inflammatory conditions. Several receptors, including FPRL-1, TLR2, TLR4, RAGE, class B scavenger receptors, SR-BI and CD36, have been identified as SAA receptors. This study provides new evidence that SR-BII, splice variant of SR-BI, could function as an SAA receptor mediating its uptake and pro-inflammatory signaling. The uptake of Alexa Fluor488 SAA was markedly (~3 fold) increased in hSR-BII-expressing HeLa cells when compared with mock-transfected cells...
2017: PloS One
https://www.readbyqxmd.com/read/28420704/influence-of-hdl-particles-on-cell-cholesterol-efflux-under-various-pathological-conditions
#19
Bela F Asztalos, Katalin V Horvath, Michael Mehan, Yuya Yokota, Ernst J Schaefer
It has been reported that low cell-cholesterol efflux capacity (CEC) of HDL is an independent risk factor for CVD. To better understand CEC regulation, we measured ABCA1- and scavenger receptor class B type I (SR-BI)-dependent cell-cholesterol efflux, HDL anti-oxidative capacity, HDL particles, lipids, and inflammatory- and oxidative-stress markers in 122 subjects with elevated plasma levels of triglyceride (TG), serum amyloid A (SAA), fibrinogen, myeloperoxidase (MPO), or β-sitosterol and in 146 controls...
June 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28404852/attachment-and-postattachment-receptors-important-for-hepatitis-c-virus-infection-and-cell-to-cell-transmission
#20
Huahao Fan, Luhua Qiao, Kyung-Don Kang, Junfen Fan, Wensheng Wei, Guangxiang Luo
Hepatitis C virus (HCV) requires multiple receptors for its attachment to and entry into cells. Our previous studies found that human syndecan-1 (SDC-1), SDC-2, and T cell immunoglobulin and mucin domain-containing protein 1 (TIM-1) are HCV attachment receptors. Other cell surface molecules, such as CD81, Claudin-1 (CLDN1), Occludin (OCLN), SR-BI, and low-density lipoprotein receptor (LDLR), function mainly at postattachment steps and are considered postattachment receptors. The underlying molecular mechanisms of different receptors in HCV cell-free and cell-to-cell transmission remain elusive...
July 1, 2017: Journal of Virology
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