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https://www.readbyqxmd.com/read/29748333/hepatic-overexpression-of-endothelial-lipase-lowers-hdl-high-density-lipoprotein-but-maintains-reverse-cholesterol-transport-in-mice-role-of-sr-bi-scavenger-receptor-class-b-type-i-abca1-atp-binding-cassette-transporter-a1-dependent-pathways
#1
Shunichi Takiguchi, Makoto Ayaori, Emi Yakushiji, Takafumi Nishida, Kazuhiro Nakaya, Makoto Sasaki, Maki Iizuka, Harumi Uto-Kondo, Yoshio Terao, Makiko Yogo, Tomohiro Komatsu, Masatsune Ogura, Katsunori Ikewaki
OBJECTIVE: Reverse cholesterol transport (RCT) is a major mechanism by which HDL (high-density lipoprotein) protects against atherosclerosis. Endothelial lipase (EL) reportedly reduces HDL levels, which, in theory, would increase atherosclerosis. However, it remains unclear whether EL affects RCT in vivo. APPROACH AND RESULTS: Adenoviral vectors expressing EL or luciferase were intravenously injected into mice, and a macrophage RCT assay was performed. As expected, hepatic EL overexpression markedly reduced HDL levels...
May 10, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29743204/apoe-isoforms-and-carboxyl-terminal-truncated-apoe4-forms-affect-neuronal-bace1-levels-and-a%C3%AE-production-independently-of-their-cholesterol-efflux-capacity
#2
Ioannis Dafnis, Christina Raftopoulou, Christina Mountaki, Evgenia Megalou, Vassilis I Zannis, Angeliki Chroni
The beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates the production of amyloid-beta peptide (Aβ) which is central to the pathogenesis of Alzheimer's disease (AD). Changes in brain cholesterol homeostasis have been suggested to affect Aβ metabolism. Cholesterol homeostasis is maintained in the brain by apolipoprotein E (apoE). The apoE4 isoform constitutes the major risk factor for AD. Here, we investigated the effect of apoE forms on Aβ generation and on BACE1 levels. We also examined the potential involvement in these processes of cholesterol transporters ABCG1 and ABCG4 or the lipoprotein receptor SR-BI that are implicated in cholesterol efflux to apoE...
May 9, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29736804/influence-of-fatty-acid-modification-on-uptake-of-lovastatin-loaded-reconstituted-high-density-lipoprotein-by-foam-cells
#3
Yun Yang, Ji Wang, Hongliang He, Wenli Zhang, Yuansheng Zhang, Jianping Liu
PURPOSE: Spherical reconstituted high density lipoprotein (rHDL) can target atherosclerotic lesions by the very low density lipoprotein (VLDL) receptor, which is seldom expressed in liver. By promoting this pathway, the targeting efficiency was hyphothesized to be improved due to avoiding undesired uptake in liver mediated by the scavenger receptor class B type I (SR-BI). In this study, how fatty acid modification in spherical rHDL influenced the VLDL receptor-mediated endocytosis pathway was investigated...
May 7, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29660655/urolithin-a-shows-anti-atherosclerotic-activity-via-activation-of-class-b-scavenger-receptor-and-activation-of-nef2-signaling-pathway
#4
Guang-Hao Cui, Wei-Qian Chen, Zhen-Ya Shen
BACKGROUND: This study investigates the therapeutic potential of urothelin A in attenuating atherosclerotic lesion in wistar rat models and explore the role of Scavenger receptor-class B type I (SR-BI) and activation of Nrf-2 singling pathway. METHODS: Wistar rats (n = 48) were feed with high cholesterol diet supplemented with Vitamin D3 and subjected to balloon injury of the aorta. Three days prior to the aortal injury, rats (n = 16) were administered urothelin A (3 mg/kg/d; po)...
May 4, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29618492/autophagy-regulates-testosterone-synthesis-by-facilitating-cholesterol-uptake-in-leydig-cells
#5
Fengyi Gao, Guoping Li, Chao Liu, Hui Gao, Hao Wang, Weixiao Liu, Min Chen, Yongliang Shang, Lina Wang, Jian Shi, Wenlong Xia, Jianwei Jiao, Fei Gao, Jian Li, Liang Chen, Wei Li
Testosterone is indispensable for sexual development and maintaining male characteristics, and deficiency of this hormone results in primary or late-onset hypogonadism (LOH). Testosterone is primarily produced in Leydig cells, where autophagy has been reported to be extremely active. However, the functional role of autophagy in testosterone synthesis remains unknown. In this study, we show that steroidogenic cell-specific disruption of autophagy influenced the sexual behavior of aging male mice because of a reduction in serum testosterone, which is similar to the symptoms of LOH...
April 4, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29596577/rare-scarb1-mutations-associate-with-high-density-lipoprotein-cholesterol-but-not-with-coronary-artery-disease
#6
Anna Helgadottir, Patrick Sulem, Gudmundur Thorgeirsson, Solveig Gretarsdottir, Gudmar Thorleifsson, Brynjar Ö Jensson, Gudny A Arnadottir, Isleifur Olafsson, Gudmundur I Eyjolfsson, Olof Sigurdardottir, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, Hilma Holm, Kari Stefansson
Aims: Scavenger receptor Class B Type 1 (SR-BI) is a major receptor for high-density lipoprotein (HDL) that promotes hepatic uptake of cholesterol from HDL. A rare mutation p.P376L, in the gene encoding SR-BI, SCARB1, was recently reported to associate with elevated HDL cholesterol (HDL-C) and increased risk of coronary artery disease (CAD), suggesting that increased HDL-C caused by SR-BI impairment might be an independent marker of cardiovascular risk. We tested the hypothesis that alleles in or close to SCARB1 that associate with elevated levels of HDL-C also associate with increased risk of CAD in the relatively homogeneous population of Iceland...
March 27, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29567540/silencing-zap70-prevents-hsp65-induced-reverse-cholesterol-transport-and-nf-%C3%AE%C2%BAb-activation-in-t-cells
#7
Jing Hu, Tiantian Luo, Dan Xi, Kai Guo, Lu Hu, Jinzhen Zhao, Si Chen, Zhigang Guo
T cell activation by antigens binding to the T cell receptor (TCR) must be properly regulated to ensure normal T cell development. The ζ chain-associated 70-kDa protein (ZAP70) is sequentially activated in response to TCR engagement and serves as a critical component of the TCR signaling pathway, which is essential for T cell activation. However, some roles of ZAP70 have not been fully elucidated. In the present study, we analyzed the effects of ZAP70 on the cholesterol efflux rate, nuclear factor κB (NF-κB) activation and cell proliferation in T cells...
March 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29541232/low-scavenger-receptor-class-b-type-i-expression-is-associated-with-gastric-adenocarcinoma-tumor-aggressiveness
#8
Xingwen Wang, Changshun Wu, Baoying Yuan, Dan Wang, Huiling Liu, Hong Feng, Shui Sun
Scavenger receptor class B type I (SR-BI), a well-documented high-density lipoprotein receptor, has been implicated in the development and progression of human cancer. However, little is known regarding the expression profile and clinical value of SR-BI in gastric adenocarcinoma. In the present study immunohistochemistry analysis was performed on a well-annotated gastric adenocarcinoma tissue microarray to investigate the association between SR-BI expression and clinicopathological parameters or patient outcome...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29523150/characterization-of-immortalized-human-dermal-microvascular-endothelial-cells-hmec-1-for-the-study-of-hdl-functionality
#9
Mónica Muñoz-Vega, Felipe Massó, Araceli Páez, Elizabeth Carreón-Torres, Hector A Cabrera-Fuentes, José Manuel Fragoso, Nonanzit Pérez-Hernández, Laurent O Martinez, Souad Najib, Gilberto Vargas-Alarcón, Óscar Pérez-Méndez
BACKGROUND: Primary cultures endothelial cells have been used as models of endothelial related diseases such atherosclerosis. Biological behavior of primary cultures is donor-dependent and data could not be easily reproducible; endothelial cell lines are emerging options, particularly, human dermal microvascular endothelial cells (HMEC-1), that should be validated to substitute primary cultures for the study of HDL functions. METHODS: Morphology, size and granularity of cells were assessed by phase contrast microscopy and flow cytometry of HMEC-1...
March 9, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29505925/dihydromyricetin-ameliorates-foam-cell-formation-via-lxr%C3%AE-abca1-abcg1-dependent-cholesterol-efflux-in-macrophages
#10
Yi Zeng, Yi Peng, Kun Tang, Yu Qin Wang, Zhe Yu Zhao, Xin Yu Wei, Xiao Le Xu
As the most abundant flavonoid in Ampelopsis grossedentata, the protective effects of dihydromyricetin on atherosclerosis have been well established, yet the detailed mechanisms are not fully understood. The aim of the present study was to examine the effect of dihydromyricetin on lipid accumulation and the underlying molecular mechanisms in macrophages and ApoE-/- mice. Incubation with dihydromyricetin significantly attenuated oxidized low-density lipoprotein (ox-LDL)-mediated cholesterol and lipid accumulation in THP-1-derived macrophages, which was due to increased cholesterol efflux...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29436680/curcumin-increases-cholesterol-efflux-via-heme-oxygenase%C3%A2-1%C3%A2-mediated-abca1-and-sr%C3%A2-bi-expression-in-macrophages
#11
Yi Zhong, Jian Feng, Zhongcai Fan, Jiafu Li
Curcumin, which is an extract from a traditional Chinese medicine, has previously been demonstrated to exhibit an anti‑atherosclerotic effect, which is closely associated with an increase in cholesterol efflux. However, it is unclear as to whether the increased effect is mediated by heme oxygenase (HO)‑1. Macrophages were treated with different concentrations of curcumin, HO‑1 inhibitor and small interfering (si)RNA in different experiments. Analysis of protein expression was conducted via western blotting...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29408809/foxo-transcription-factors-are-required-for-hepatic-hdl-cholesterol-clearance
#12
Samuel X Lee, Markus Heine, Christian Schlein, Rajasekhar Ramakrishnan, Jing Liu, Gabriella Belnavis, Ido Haimi, Alexander W Fischer, Henry N Ginsberg, Joerg Heeren, Franz Rinninger, Rebecca A Haeusler
Insulin resistance and type 2 diabetes are associated with low levels of high-density lipoprotein cholesterol (HDL-C). The insulin-repressible FoxO transcription factors are potential mediators of the effect of insulin on HDL-C. FoxOs mediate a substantial portion of insulin-regulated transcription, and poor FoxO repression is thought to contribute to the excessive glucose production in diabetes. In this work, we show that mice with liver-specific triple FoxO knockout (L-FoxO1,3,4), which are known to have reduced hepatic glucose production, also have increased HDL-C...
April 2, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29407889/microrna-24-aggravates-atherosclerosis-by-inhibiting-selective-lipid-uptake-from-hdl-cholesterol-via-the-post-transcriptional-repression-of-scavenger-receptor-class-b-type-i
#13
Kun Ren, Xiao Zhu, Zhi Zheng, Zhong-Cheng Mo, Xiao-Shan Peng, Yong-Zhi Zeng, Han-Xiao Ou, Qing-Hai Zhang, Hui-Zhou Qi, Guo-Jun Zhao, Guang-Hui Yi
BACKGROUND AND AIMS: Liver scavenger receptor class B type I (SR-BI) exerts atheroprotective effects through selective lipid uptake (SLU) from high-density lipoprotein cholesterol (HDL-C). Low hepatic SR-BI expression leads to high HDL-C levels in the circulation and an increased risk of atherosclerosis. Furthermore, macrophage SR-BI mediates bidirectional cholesterol flux and may protect against atherogenesis. Previous studies have revealed that miR-24 is closely related to cardiovascular disease (CVD) progression...
March 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29394450/the-expression-of-lipoprotein-receptors-is-increased-in-the-infarcted-area-after-myocardial-infarction-induced-in-rats-with-cardiac-dysfunction
#14
Aline D de Lima, Maria C Guido, Elaine R Tavares, Priscila O Carvalho, Alyne F Marques, Marcelo D T de Melo, Vera M C Salemi, Roberto Kalil-Filho, Raul C Maranhão
Left ventricular (LV) remodeling after myocardial infarction constitutes the structural basis for ventricular dysfunction and heart failure. The characterization underlying the expression of lipoprotein receptors in cardiac dysfunction is scarcely explored. The aim of this study was to analyze the status of lipoprotein receptors on the infarcted and noninfarcted areas of LV and to verify whether nanoparticles that mimic the lipid structure of low-density lipoprotein (LDL) and have the ability to bind to LDL receptors (LDE) are taken up more avidly by the noninfarcted LV...
February 2018: Lipids
https://www.readbyqxmd.com/read/29370800/a-novel-immortalized-hepatocyte-like-cell-line-imhc-supports-in-vitro-liver-stage-development-of-the-human-malarial-parasite-plasmodium-vivax
#15
Yongyut Pewkliang, Siriwan Rungin, Kaewta Lerdpanyangam, Apisak Duangmanee, Phongthon Kanjanasirirat, Phichaya Suthivanich, Khanit Sa-Ngiamsuntorn, Suparerk Borwornpinyo, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Suradej Hongeng
BACKGROUND: Eradication of malaria is difficult because of the ability of hypnozoite, the dormant liver-stage form of Plasmodium vivax, to cause relapse in patients. Research efforts to better understand the biology of P. vivax hypnozoite and design relapse prevention strategies have been hampered by the lack of a robust and reliable model for in vitro culture of liver-stage parasites. Although the HC-04 hepatoma cell line is used for culturing liver-stage forms of Plasmodium, these cells proliferate unrestrictedly and detach from the culture dish after several days, which limits their usefulness in a long-term hypnozoite assay...
January 25, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29365431/hdl-deliver-cholesterol-to-cultured-cells-by-a-sr-bi-independent-mechanism-hmec-1-as-endothelial-cell-model
#16
Mónica Muñoz-Vega, Felipe Massó-Rojas, Araceli Páez-Arenas, Oscar Pérez-Méndez
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29357836/up-regulation-of-sr-bi-promotes-progression-and-serves-as-a-prognostic-biomarker-in-clear-cell-renal-cell-carcinoma
#17
Guang-Hua Xu, Ning Lou, Hang-Chuan Shi, Yu-Chen Xu, Hai-Long Ruan, Wen Xiao, Lei Liu, Xiang Li, Hai-Bing Xiao, Bin Qiu, Lin Bao, Chang-Fei Yuan, Ya-Li Zhou, Wen-Jun Hu, Ke Chen, Hong-Mei Yang, Xiao-Ping Zhang
BACKGROUND: Scavenger receptor class B type I (SR-BI) has been reported to be involved in carcinogenesis of several human cancers. However, it is currently unknown whether SR-BI plays a role in clear cell renal cell carcinoma (ccRCC). Here, we aimed to evaluate a tumor promotive mechanism for SR-BI in ccRCC. METHODS: The expression of SR-BI was evaluated by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), Western blot and immunohistochemistry (IHC) in ccRCC tissues and cell lines...
January 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29334216/lysosome-independent-intracellular-drug-gene-codelivery-by-lipoprotein-derived-nanovector-for-synergistic-apoptosis-inducing-cancer-targeted-therapy
#18
Wei Wang, Kerong Chen, Yujie Su, Jielei Zhang, Min Li, Jianping Zhou
In this paper, reconstituted high-density lipoprotein (rHDL), a lipoprotein-derived nanovector, was constructed for codelivery of paclitaxel (PTX) and wild-type p53 gene (p53). The particle size and the zeta potential of PTX-DODAB/p53-rHDL nanoparticles were 177.2 nm and -20.06 mV, respectively. Meanwhile, they exhibited great serum stability and satisfactory sustained release characteristics in vitro. PTX-DODAB/pDNA-rHDL nanoparticles simultaneously improved the cellular uptake of PTX and pDNA via scavenger receptor B type I (SR-BI) mediated lysosome-independent internalization and promoted the transfection of pDNA in MCF-7 cells, which were revealed by flow cytometry and confocal laser scanning microscopy analyses...
February 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29281244/high-density-lipoprotein-nanobiologics-for-precision-medicine
#19
Willem J M Mulder, Mandy M T van Leent, Marnix Lameijer, Edward A Fisher, Zahi A Fayad, Carlos Pérez-Medina
Nature is an inspirational source for biomedical engineering developments. Particularly, numerous nanotechnological approaches have been derived from biological concepts. For example, among many different biological nanosized materials, viruses have been extensively studied and utilized, while exosome research has gained much traction in the 21st century. In our body, fat is transported by lipoproteins, intriguing supramolecular nanostructures that have important roles in cell function, lipid metabolism, and disease...
January 16, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29274774/nanotherapy-for-alzheimer-s-disease-and-vascular-dementia-targeting-senile-endothelium
#20
REVIEW
Joseph S D'Arrigo
Due to the complexity of Alzheimer's disease, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted lipid nanoemulsion) are available. Versatile small molecule drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. By incorporating such drug(s) into the targeted "lipid-coated microbubble" [LCM]/"nanoparticle-derived" [ND] (or LCM/ND) nanoemulsion type, one obtains a multitasking combination therapeutic for translational medicine...
January 2018: Advances in Colloid and Interface Science
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