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https://www.readbyqxmd.com/read/28079289/apocrine-metaplasia-found-at-mr-biopsy-is-there-something-to-be-learned
#1
Yiming Gao, Vandana Dialani, Carolynn DeBenedectis, Nicole Johnson, Elena Brachtel, Priscilla Slanetz
The purpose of this study was to determine (a) the frequency of apocrine metaplasia (ApoM) found on MR core biopsy of suspicious findings, and (b) to determine if there are specific MR imaging features that might obviate the need for biopsy. This HIPAA-compliant retrospective study was performed under IRB exemption for quality assurance studies. Patient demographics, MR imaging features, and pathology were reviewed. Breast lesions which underwent MR-guided biopsy, yielding ApoM on pathology analysis were included...
January 12, 2017: Breast Journal
https://www.readbyqxmd.com/read/28073663/apom-hdl-c-and-apom-apoa-i-ratios-are-indicators-of-diabetic-nephropathy-in-healthy-controls-and-type-2-diabetes-mellitus
#2
Puhong Zhang, Jialin Gao, Chun Pu, Gang Feng, Lizhuo Wang, Lizhu Huang, Yao Zhang
BACKGROUND: Apolipoprotein M (apoM) concentrations were decreased in type 2 diabetes mellitus (T2DM). ApoM was selectively expressed in renal tubular epithelial cells. We investigated the changes in plasma apoM concentrations in diabetic nephropathy (DN) patients and the potential of apoM as a biomarker of DN. METHODS: A total of 96 DN patients and 100 age- and sex-matched diabetic non-nephropathy (non-DN) patients and 110 healthy controls were included. All T2DM patients were divided into 3 groups according to urinary albumin excretion: normoalbuminuria (n=100), microalbuminuria (n=50) and macroalbuminuria (n=46)...
January 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28039587/tgf-%C3%AE-down-regulates-apolipoprotein-m-expression-through-the-tak-1-jnk-c-jun-pathway-in-hepg2-cells
#3
Kun Ren, Zhong-Cheng Mo, Xing Liu, Zhen-Li Tang, Yue Jiang, Xiao-Shan Peng, Qing-Hai Zhang, Jin-Feng Shi, Guang-Hui Yi
Apolipoprotein M (apoM) is a relatively novel apolipoprotein that plays pivotal roles in many dyslipidemia-associated diseases; however, its regulatory mechanisms are poorly understood. Many cytokines have been identified that down-regulate apoM expression in HepG2 cells, among which transforming growth factor-β (TGF-β) exerts the most potent effects. In addition, c-Jun, a member of the activated protein 1 (AP-1) family whose activity is modulated by c-Jun N-terminal kinase (JNK), decreases apoM expression at the transcriptional level by binding to the regulatory element in the proximal apoM promoter...
December 30, 2016: Lipids
https://www.readbyqxmd.com/read/28038379/high-density-lipoprotein-hdl-associated-sphingosine-1-phosphate-s1p-inhibits-macrophage-apoptosis-by-stimulating-stat3-activity-and-survivin-expression
#4
Renata Feuerborn, Susen Becker, Francesco Potì, Petra Nagel, Martin Brodde, Harmut Schmidt, Christina Christoffersen, Uta Ceglarek, Ralph Burkhardt, Jerzy-Roch Nofer
BACKGROUND AND AIMS: Macrophage apoptosis is critically involved in atherosclerosis. We here examined the effect of anti-atherogenic high density lipoprotein (HDL) and its component sphingosine-1-phosphate (S1P) on apoptosis in RAW264.7 murine macrophages. METHODS: Mitochondrial or endoplasmic reticulum-dependent apoptosis was induced by exposure of macrophages to etoposide or thapsigargin/fukoidan, respectively. RESULTS: Cell death induced by these compounds was inhibited by S1P as inferred from reduced annexin V binding, TUNEL staining, and caspase 3, 9 and 12 activities...
December 9, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27927202/positive-association-between-serum-apolipoprotein-m-levels-and-hepatitis-b-virus-dna-load-in-hbeag-negative-chronic-hepatitis-b
#5
Ting Shen, Wei Min Wu, Wen Han Du, Lin Wang, La Gu He, Li Tan, ZeYou Wang, Ruohong Chen, Min Hu, Ya Ping Ren
BACKGROUND: Hepatitis virus B (HBV) has infected millions of people worldwide. Notably, such infections can be associated with hepatic complications. Levels of apolipoprotein M (apoM), a component of high-density lipoprotein (HDL), are known to be significantly elevated in patients with chronic hepatitis B (CHB). The aim of this study was to investigate the relationship between HBV DNA load in serum and serum apoM levels in patients with CHB. METHODS: A total of 73 HBeAg-negative CHB patients, 50 HBeAg-positive CHB patients, and 79 non-CHB controls were included in the study cohort...
December 7, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27879252/high-density-lipoprotein-associated-apolipoprotein-m-limits-endothelial-inflammation-by-delivering-sphingosine-1-phosphate-to-the-sphingosine-1-phosphate-receptor-1
#6
Mario Ruiz, Cecilia Frej, Andreas Holmér, Li J Guo, Sinh Tran, Björn Dahlbäck
OBJECTIVE: Plasma high-density lipoproteins (HDL) are potent antiatherogenic and anti-inflammatory particles. However, HDL particles are highly heterogenic in composition, and different HDL-mediated functions can be ascribed to different subclasses of HDL. Only a small HDL population contains apolipoprotein M (ApoM), which is the main plasma carrier of the bioactive lipid mediator sphingosine-1-phosphate (S1P). Vascular inflammation is modulated by S1P, but both pro- and anti-inflammatory roles have been ascribed to S1P...
January 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27633510/effects-of-hyperlipidaemia-on-plasma-apolipoprotein-m-levels-in-patients-with-type-2-diabetes-mellitus-an-independent-case-control-study
#7
Puhong Zhang, Jialin Gao, Chun Pu, Gang Feng, Lizhuo Wang, Lizhu Huang, Qingsong Tao, Yao Zhang
BACKGROUND: Apolipoprotein M (apoM) is mainly enriched in high-density lipoprotein (HDL) cholesterol and is slightly present in low-density lipoprotein (LDL) cholesterol and very low-density lipoprotein cholesterol. apoM is involved in HDL formation and HDL-mediated reverse cholesterol transport. apoM is also associated with hyperlipidaemia and type 2 diabetes mellitus (T2DM). Significantly high plasma apoM levels are detected in hyperlipidaemia mice with a defective LDL receptor. By contrast, low plasma apoM levels are observed in patients with T2DM, which is often accompanied with hyperlipidaemia...
September 15, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27617241/postmenopausal-osteoporosis-is-associated-with-serum-chemerin-and-irisin-but-not-with-apolipoprotein-m-levels
#8
Yaprak Engin-Üstün, Emel Kıyak Çağlayan, Ayşe Yeşim Göçmen, Muhammed Fevzi Polat
OBJECTIVES: The objective of this study was to describe the levels of chemerin, irisin and apolipoprotein M (apoM) in women with postmenopausal osteoporosis. METHODS: The study included 88 women with postmenopausal osteoporosis. Based on World Health Organization criteria, women with a T-score of ≤ -2.5 were defined as osteoporotic. In this case-control study, postmenopausal women with T-score > -1 were selected as controls (n = 88) and case-matched in a 1:1 ratio based on age (within 2 years) and body mass index (BMI) (within 1...
August 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/27576735/a-single-nucleotide-polymorphism-c-724-del-in-the-proter-region-of-the-apolipoprotein-m-gene-is-associated-with-type-2-diabetes-mellitus
#9
Pu-Hong Zhang, Jia-Lin Gao, Chun Pu, Gang Feng, Li-Zhuo Wang, Li-Zhu Huang, Yao Zhang
BACKGROUND: Apolipoprotein M (apoM) was the carrier of the biologically active lipid mediator sphingosine-1-phospate in high density lipoprotein cholesterol (HDL-C) and played a critical role in formation and maturation of prebeta-HDL-C particles. The plasma apoM levels were decreased obviously in patients with type 2 diabetes mellitus (T2DM). A new single-nucleotide polymorphism (SNP) C-724del in apoM promoter was associated with a higher risk for coronary artery diseases (CAD) and myocardial infarction, could reduce promoter activities and apoM expression in vitro...
August 30, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27476912/binding-characteristics-of-sphingosine-1-phosphate-to-apom-hints-to-assisted-release-mechanism-via-the-apom-calyx-opening
#10
Hansi Zhang, Kristyna Pluhackova, Zhenyan Jiang, Rainer A Böckmann
Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator carried by the HDL-associated apoM protein in blood, regulating many physiological processes by activating the G protein-coupled S1P receptor in mammals. Despite the solved crystal structure of the apoM-S1P complex, the mechanism of S1P release from apoM as a part of the S1P pathway is unknown. Here, the dynamics of the wild type apoM-S1P complex as well as of mutants were investigated by means of atomistic molecular dynamics simulations. The potential of mean force for S1P unbinding from apoM reflected a large binding strength of more than 60 kJ/mol...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27444045/a-novel-approach-for-measuring-sphingosine-1-phosphate-and-lysophosphatidic-acid-binding-to-carrier-proteins-using-monoclonal-antibodies-and-the-kinetic-exclusion-assay
#11
Jonathan K Fleming, Thomas R Glass, Steve J Lackie, Jonathan M Wojciak
Sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive signaling lysophospholipids that activate specific G protein-coupled receptors on the cell surface triggering numerous biological events. In circulation, S1P and LPA associate with specific carrier proteins or chaperones; serum albumin binds both S1P and LPA while HDL shuttles S1P via interactions with apoM. We used a series of kinetic exclusion assays in which monoclonal anti-S1P and anti-LPA antibodies competed with carrier protein for the lysophospholipid to measure the equilibrium dissociation constants (Kd) for these carrier proteins binding S1P and the major LPA species...
September 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27412944/-correlation-between-the-genetic-polymorphisms-of-apolipoprotein-m-with-the-susceptibility-to-rheumatic-diseases-of-chinese-han-populastion-in-lanzhou
#12
Meiyong Li, Xinling Guo, Qiannan Li, Chongge You
Objective To investigate the relationship between the genetic polymorphisms of apolipoprotein M (ApoM) and the susceptibility to rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) among Chinese Han population in Lanzhou. Methods Primers for the two single nucleotide polymorphism (SNP) sites (rs805296 and rs805297) in ApoM gene were designed and their genotyping methods of polymerase chain reaction-high resolution melting (PCR-HRM) assay were established. Case-control studies were performed among the 599 cases of RA, 194 cases of SLE, 179 cases of AS and 273 matched healthy controls to analyze the correlations between the two SNPs and the susceptibility to rheumatic diseases...
August 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27318702/sphingosine-1-phosphate-s1p-and-s1p-signaling-pathway-therapeutic-targets-in-autoimmunity-and-inflammation
#13
Hsing-Chuan Tsai, May H Han
Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are ubiquitously expressed. S1P-S1PR signaling has been well characterized in immune trafficking and activation in innate and adaptive immune systems. However, the full extent of its involvement in the pathogenesis of autoimmune diseases is not well understood. FTY720 (fingolimod), a non-selective S1PR modulator, significantly decreased annualized relapse rates in relapsing-remitting multiple sclerosis (MS). FTY720, which primarily targets S1P receptor 1 as a functional antagonist, arrests lymphocyte egress from secondary lymphoid tissues and reduces neuroinflammation in the central nervous system (CNS)...
July 2016: Drugs
https://www.readbyqxmd.com/read/27277397/identification-of-polymorphisms-in-apolipoprotein-m-gene-and-their-relationship-with-risk-of-recurrent-venous-thromboembolism
#14
Abrar Ahmad, Kristina Sundquist, Bengt Zöller, Björn Dahlbäck, Peter J Svensson, Jan Sundquist, Ashfaque A Memon
Apolipoprotein M (ApoM) plasma levels have been reported to be associated with risk of venous thromboembolism (VTE) recurrence. However, the role of genetic alterations in the ApoM gene in VTE recurrence remains unknown. The aim of this study was to identify genetic aberrations in ApoM gene in VTE recurrence and their role in prediction of VTE recurrence in a prospective follow-up study of 1465 VTE patients. During follow-up, 156 (10.6 %) patients had VTE recurrence. First screening of whole ApoM gene was performed by Sanger's sequencing in selected age and sex matched non-recurrent and recurrent patients (n=95)...
August 30, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27208892/familial-hypercholesterolaemia-cholesterol-efflux-and-coronary-disease
#15
Jorie Versmissen, Ranitha Vongpromek, Reyhana Yahya, Jeroen B van der Net, Leonie van Vark-van der Zee, Jeannette Blommesteijn-Touw, Darcos Wattimena, Trinet Rietveld, Clive R Pullinger, Christina Christoffersen, Björn Dahlbäck, John P Kane, Monique Mulder, Eric J G Sijbrands
BACKGROUND: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. MATERIALS AND METHODS: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM)...
July 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27206623/serum-high-density-lipoprotein-correlates-with-serum-apolipoprotein-m-and-a5-in-obstructive-sleep-apnea-hypopnea-syndrome
#16
Shengyu Tan, Xianling Liu, Yan Xu, Lu Luo, Shenghua Zhou, Yawen Gao
PURPOSE: The purpose of this study was to investigate the correlation between serum levels of serum apolipoprotein M (ApoM), A5 (ApoA5), and high-density lipoprotein (HDL) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and study the effects of nasal continuous positive airway pressure treatment on these serum biomarkers. METHODS: Thirty OSAHS patients and 15 non-OSAHS probands as control were selected for the study. Serum HDL, ApoM, and ApoA5 levels in two groups were detected; differences and association among them were analyzed...
May 21, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27001252/high-apolipoprotein-m-serum-levels-correlate-with-chronic-obstructive-pulmonary-disease
#17
Hui Li, Yinyin Liu, Ling Wang, Ting Shen, Wenhan Du, Zhijun Liu, Ruohong Chen, Min Hu
BACKGROUND: Recently, variations in a component of high-density lipoprotein (HDL), namely apolipoprotein M (apoM), were found to be associated with chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the association between apoM and COPD severity. Factors associated with apoM, COPD, or coronary artery disease (CAD) were also assessed. METHODS: A total of 110 COPD patients and 110 age- and sex-matched non-COPD controls were included...
March 22, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26997169/lipoprotein-composition-in-patients-with-type-1-diabetes-mellitus-impact-of-lipases-and-adipokines
#18
Thomas A Hughes, Rossana M Calderon, Sylvia Diaz, Armando J Mendez, Ronald B Goldberg
OBJECTIVE: High cardiovascular mortality in patients with type 1 diabetes (T1DM) is widely recognized. Paradoxically, these patients have been shown to have elevated HDL-C and reduced apoB-containing lipoproteins. The purpose of this investigation was to further characterize the lipoprotein composition in T1DM and to assess the role that lipases and adipokines may play in these differences. METHODS: T1DM patients (89) attending the Diabetes Clinic at the University of Miami and 42 healthy controls were recruited...
May 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/26990127/sphingosine-1-phosphate-and-its-carrier-apolipoprotein-m-in-human-sepsis-and-in-escherichia-coli-sepsis-in-baboons
#19
Cecilia Frej, Adam Linder, Kaisa E Happonen, Fletcher B Taylor, Florea Lupu, Björn Dahlbäck
Sphingosine 1-phosphate (S1P) is an important regulator of vascular integrity and immune cell migration, carried in plasma by high-density lipoprotein (HDL)-associated apolipoprotein M (apoM) and by albumin. In sepsis, the protein and lipid composition of HDL changes dramatically. The aim of this study was to evaluate changes in S1P and its carrier protein apoM during sepsis. For this purpose, plasma samples from both human sepsis patients and from an experimental Escherichia coli sepsis model in baboons were used...
June 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/26956418/impaired-endothelial-barrier-function-in-apolipoprotein-m-deficient-mice-is-dependent-on-sphingosine-1-phosphate-receptor-1
#20
Pernille M Christensen, Catherine H Liu, Steven L Swendeman, Hideru Obinata, Klaus Qvortrup, Lars B Nielsen, Timothy Hla, Annarita Di Lorenzo, Christina Christoffersen
Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have ∼50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P1 receptor, which in turn suppresses vascular leak. Increased vascular permeability is a hallmark of inflammation. The purpose of this study was to explore the relationships between vascular leakage in ApoM deficiency and S1P1 function in normal physiology and in inflammation...
June 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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