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https://www.readbyqxmd.com/read/27933750/comparing-glucose-and-hemoglobin-a1c-diagnostic-tests-among-a-high-metabolic-risk-hispanic-population
#1
Mónica A Vega-Vázquez, Margarita Ramirez-Vick, Francisco J Muñoz-Torres, Loida A González-Rodríguez, Kaumudi Joshipura
AIMS: Compare HbA1c diagnostic tests for pre-diabetes and diabetes with plasma glucose criteria (PGC), and compare the metabolic profiles of people classified by HbA1c versus by glucose levels. METHODS: Participants were recruited for the San Juan Overweight Adults Longitudinal Study (SOALS). Were primarily Hispanic (98%), without previously diagnosed diabetes, and aged 40-65 years. Participants classified as normal glycemic, pre-diabetes or diabetes based on baseline HbA1c and PGC, were compared with respect to baseline cardiometabolic factors...
December 9, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27933718/constipation-in-older-people-a-consensus-statement
#2
Anton Emmanuel, Francesco Mattace-Raso, Maria Cristina Neri, Karl-Uwe Petersen, Enrique Rey, June Rogers
BACKGROUND AND AIMS: Chronic constipation is a serious medical condition that affects 30%-40% of people over 60 years old. Although not normally life threatening, constipation reduces quality of life by the same extent as diabetes and osteoarthritis. There are currently no Europe-wide guidelines for treating constipation in older people, although there is some country-level guidance for the general population. We have evaluated the existing guidance and best clinical practice to improve the care of older people with constipation...
December 9, 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27933715/efficacy-of-self-monitoring-of-blood-glucose-versus-retrospective-continuous-glucose-monitoring-in-improving-glycaemic-control-in-diabetic-kidney-disease-patients
#3
Ester Chai Kheng Yeoh, Boon Khim Lim, Sharon Fun, Julia Tong, Lee Ying Yeoh, Chee Fang Sum, Tavintharan Subramaniam, Su Chi Lim
AIMS: Patients with diabetic kidney disease (DKD) on anti-diabetic agents, are at greater risk of glycemic variations, both hypoglycemia and hyperglycemia. We aimed to compare glycemic control (using HbA1c) and hypoglycemia incidence in patients with Stage 3 DKD (eGFR 30-60 ml/min/1.73 m(2) ), receiving retrospective CGM-guided anti-diabetic therapy versus self-monitoring of blood glucose (SMBG) over 3 months. METHODS: Thirty patients with HbA1c > 8% were randomized to 6-day retrospective CGM or SMBG...
December 9, 2016: Nephrology
https://www.readbyqxmd.com/read/27933711/using-a-co-production-prioritization-exercise-involving-south-asian-children-young-people-and-their-families-to-identify-health-priorities-requiring-further-research-and-public-awareness
#4
Logan Manikam, Rakhee Shah, Kate Reed, Gupreet Santini, Monica Lakhanpaul
OBJECTIVES: To facilitate South Asian (SA) families and health-care professionals (HCPs) participation in a prioritization exercise to co-produce child health research and public awareness agendas. DESIGN: A three-stage process was adopted involving the following: (i) systematic literature review, (ii) HCP scoping survey and (iii) focus groups of SA adolescents and families. A Punjabi- and Urdu-speaking community facilitator moderated focus groups. A British Sign Language interpreter assisted in the hard of hearing group...
December 8, 2016: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/27933671/causal-inference-in-obesity-research
#5
REVIEW
P W Franks, N Atabaki-Pasdar
Obesity is a risk factor for a plethora of severe morbidities and premature death. Most supporting evidence comes from observational studies that are prone to chance, bias and confounding. Even data on the protective effects of weight loss from randomized controlled trials will be susceptible to confounding and bias if treatment assignment cannot be masked, which is usually the case with lifestyle and surgical interventions. Thus, whilst obesity is widely considered the major modifiable risk factor for many chronic diseases, its causes and consequences are often difficult to determine...
December 8, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27933635/vietnamese-version-of-diabetes-self-management-instrument-development-and-psychometric-testing
#6
Tiet-Hanh Dao-Tran, Debra J Anderson, Anne M Chang, Charrlotte Seib, Cameron Hurst
Self-management plays a vital role in diabetes management for adults with type 2 diabetes (T2DM). While there are many people with T2DM in Vietnam, clinical understanding of diabetes self-management (DSM) in this context is limited due to the lack of a valid measurement instrument. Translation and back-translation processes were used to translate the Diabetes Self-Management Instrument (DSMI) into Vietnamese. Then, translation equivalence, face validity, construct validity, and internal consistency were assessed in a sample of 198 Vietnamese adults with T2DM...
December 9, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27933575/-fast-acting-insulin-new-developments-towards-more-flexibility-for-the-patient
#7
Gerhard W Schmeisl, Yasmin Kretzschmar
BACKGROUND: Post-prandial insulin secretion occurs under physiological conditions very fast and in adequate concentrations. This mechanism is impaired in patients with type 2 diabetes and severe increases of postprandial glucose levels may occur. In order to achieve physiological conditions and to avoid postprandial hyperglycemia, exogenous insulin and insulin analogues should be absorbed very fast and appropriate maximum concentrations should be reached very quickly. METHOD: Overview RESULTS AND CONCLUSIONS: The development of new bolus insulins is focused on improved pharmacokinetic and pharmacodynamic properties...
December 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27933546/using-systems-genetics-to-understanding-the-etiology-of-complex-disease
#8
Ramesh Ram, Grant Morahan
Here, we discuss Systems Genetics applications for systematic evaluation of candidate causal genes together with follow-up bioinformatics pathway analysis. The aim of this chapter is to illustrate analytic procedures and we provide examples in the context of Type 1 diabetes (T1day), the risk of which is conferred by over 60 loci. We also describe the Type 1 Diabetes Systems Genetics website and provide a guide for its use and application to other diseases.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933519/heterogeneous-stock-populations-for-analysis-of-complex-traits
#9
Leah C Solberg Woods, Richard Mott
Heterogeneous Stock (HS) populations allow for fine-resolution genetic mapping of a variety of complex traits. HS mice and rats were created from breeding together eight inbred strains, followed by maintaining the colony in a manner that minimizes inbreeding. After 50 or more generations of breeding, the resulting animals' chromosomes represent a genetic mosaic of the founders' haplotypes, with the average distance between recombination events in the centiMorgan range. This allows for genetic mapping to only a few Mb, a much smaller region than what can be identified using traditional F2 intercross or backcross mapping strategies...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933516/costs-of-diabetes-medication-among-male-former-elite-athletes-in-later-life
#10
M K Laine, R Kujala, J G Eriksson, H Kautiainen, S Sarna, U M Kujala
AIMS: Regular physical activity plays a major role, in both prevention and treatment of type 2 diabetes. Less is known whether vigorous physical activity during young adulthood is associated with costs of diabetes medication in later life. The aim of this study is to evaluate this question. METHODS: The study population consisted of 1314 former elite-class athletes and 860 matched controls. The former athletes were divided into three groups based on their active career sport: endurance, mixed and power sports...
December 8, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27933515/serum-bilirubin-concentrations-and-incident-coronary-heart-disease-risk-among-patients-with-type-2-diabetes-the-dongfeng-tongji-cohort
#11
Jing Wang, Xiaofen Wu, Yaru Li, Xu Han, Hua Hu, Fei Wang, Caizheng Yu, Xiulou Li, Kun Yang, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Weihong Chen, Yuan Liang, Huan Guo, Handong Yang, Tangchun Wu, Xiaomin Zhang, Meian He
AIMS: Elevated serum bilirubin levels are associated with decreased coronary heart disease (CHD) risk in cross-sectional studies among diabetic patients, but prospective evidence is limited. We investigated the relationship of serum bilirubin levels with incident CHD risk among type 2 diabetes patients. METHODS: In a prospective study of 2918 type 2 diabetes embedded in the Dongfeng-Tongji cohort, serum total bilirubin (TBil), direct bilirubin (DBil), and indirect bilirubin (IBil) were measured at baseline...
December 8, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27933514/changes-in-cardiac-repolarisation-during-spontaneous-nocturnal-hypoglycaemia-in-subjects-with-type-1-diabetes-a-preliminary-report
#12
Minna L Koivikko, Tuomas Kenttä, Pasi I Salmela, Heikki V Huikuri, Juha S Perkiömäki
AIMS: Experimental studies have revealed that hypoglycaemia can result in morphological changes in electrocardiographic repolarisation in subjects with type 1 diabetes. However, the influence of spontaneous nocturnal hypoglycaemia on repolarisation morphology in a 'real life' situation is not clear. METHODS: Adults with type 1 diabetes (n = 11) underwent continuous glucose monitoring with a subcutaneous sensor and digital 12-lead ECG recording for three nights...
December 8, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27933508/patterns-of-diabetes-care-in-slovenia-croatia-serbia-bulgaria-and-romania-an-observational-non-interventional-cross-sectional-study
#13
Miro Cokolic, Nebojsa M Lalic, Dragan Micic, Gorana Mirosevic, Sanja Klobucar Majanovic, Ivaylo N Lefterov, Mariana Graur
BACKGROUND: National guidelines for treating type 2 diabetes in the Balkans generally follow European guidelines. The current study was undertaken to estimate the rate of glycated hemoglobin (HbA1c) measurements and level of HbA1c control in diabetic patients treated in regular clinical practice settings in the Balkans and to evaluate if providing HbA1c measurements improves adherence to treatment guidelines. METHODS: This cross-sectional study enrolled type 2 diabetic patients treated by 79 primary care physicians and 102 specialists...
December 8, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27933507/determinants-of-maternal-vitamin%C3%A2-d-concentrations-in-slovenia-a%C3%A2-prospective-observational-study
#14
Andraž Dovnik, Faris Mujezinović, Milena Treiber, Breda Pečovnik Balon, Maksimiljan Gorenjak, Uroš Maver, Iztok Takač
OBJECTIVE: To analyze the vitamin D status of pregnant women in Slovenia and the factors influencing it. METHODS: The study was performed in Maribor University Medical Centre (location 46°N). Maternal serum 25-hydroxy-vitamin D (25(OH)D) in 4 groups of 100 pregnant women in 4 different seasons of the year was measured at the time of delivery. Data on life style, eating habits, sunbathing and intake of vitamin D supplements during pregnancy were obtained using a questionnaire...
December 8, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27933471/factors-associated-with-medication-non-adherence-in-patients-with-end-stage-liver-disease
#15
Selena Z Kuo, Marta Haftek, Jennifer C Lai
BACKGROUND: Low medication adherence is known to contribute to worse health outcomes in the general population. AIM: We aimed to evaluate the medication regimen and determine the adherence levels among patients with end-stage liver disease. METHODS: We measured adherence in patients awaiting liver transplantation at a single center using the 8-item Morisky Medication Adherence Scale (MMAS-8), with a score <8 classified as low adherence...
December 8, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27933435/ranolazine-promotes-muscle-differentiation-and-reduces-oxidative-stress-in-c2c12-skeletal-muscle-cells
#16
Terruzzi Ileana, Montesano Anna, Senesi Pamela, Vacante Fernanda, Benedini Stefano, Luzi Livio
PURPOSE: The purpose of this study is to investigate Ranolazine action on skeletal muscle differentiation and mitochondrial oxidative phenomena. Ranolazine, an antianginal drug, which acts blocking the late INaL current, was shown to lower hemoglobin A1c in patients with diabetes. In the present study, we hypothesized an action of Ranolazine on skeletal muscle cells regeneration and oxidative process, leading to a reduction of insulin resistance. METHODS: 10 μM Ranolazine was added to C2C12 murine myoblastic cells during proliferation, differentiation and newly formed myotubes...
December 8, 2016: Endocrine
https://www.readbyqxmd.com/read/27933415/association-between-gamma-glutamyltransferase-and-albuminuria-in-nondiabetic-adults-with-normal-renal-function
#17
Sun-Hye Ko, Myong Ki Baeg, Kyung-Do Han, Seung-Yeon Ko, Sae-Bom Shin, Seung-Hyun Ko, Yu-Bae Ahn
BACKGROUND: Serum gamma-glutamyltransferase (GGT) has been associated with albuminuria in diabetes patients, but it has not been investigated in the general population. We aimed to investigate the association between serum GGT and albuminuria in the nondiabetic Korean population with normal kidney function. METHODS: Study participants (3948; 1549 men and 2399 women) with an estimated glomerular filtration rate ≥60 mL/min/1.73 m(2) were analyzed from the fifth Korean National Health and Nutrition Examination Survey (2011)...
December 9, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27933382/the-impact-of-hereditary-multiple-exostoses-on-quality-of-life-satisfaction-global-health-status-and-pain
#18
Riccardo D'Ambrosi, Vincenza Ragone, Camilla Caldarini, Nicola Serra, Federico Giuseppe Usuelli, Renato Mario Facchini
PURPOSE: The aim of the study was to evaluate quality of life (QOL), global health status, pain, and level of satisfaction in patients with hereditary multiple exostoses (HME), and to correlate the association between the severity of diseases and age, sex, number of surgical procedures, and number of exostoses. METHODS: The data of 50 patients with HME were retrospectively evaluated and recorded. QOL was evaluated with the Short-Form Health Survey (SF-12) questionnaire, the 12-Item General Health Questionnaire (GHQ-12), and Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q-SF); intensity of pain was measured using the visual analogue scale (VAS)...
December 8, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27933336/shp-1-activation-inhibits-vascular-smooth-muscle-cell-proliferation-and-intimal-hyperplasia-in-a-rodent-model-of-insulin-resistance-and-diabetes
#19
Weier Qi, Qian Li, Chong Wee Liew, Christian Rask-Madsen, Samuel M Lockhart, Lars Melholt Rasmussen, Yu Xia, Xuanchun Wang, Mogher Khamaisi, Kevin Croce, George L King
AIMS/HYPOTHESIS: Accelerated migration and proliferation of vascular smooth muscle cells (VSMCs) enhances arterial restenosis after angioplasty in insulin resistance and diabetes. Elevation of Src homology 2-containing protein tyrosine phosphatase 1 (SHP-1) induces apoptosis in the microvasculature. However, the role of SHP-1 in intimal hyperplasia and restenosis has not been clarified in insulin resistance and diabetes. METHODS: We used a femoral artery wire injury mouse model, rodent models with insulin resistance and diabetes, and patients with type 2 diabetes...
December 9, 2016: Diabetologia
https://www.readbyqxmd.com/read/27933335/iron-how-much-is-too-much
#20
EDITORIAL
Aidan McElduff
Gross iron overload has long been known to result in diabetes mellitus. However, it is now thought that milder levels of iron overload, possibly within the normal range, also increase the risk of diabetes mellitus. The article by Rawal et al in this issue (Diabetologia doi: 10.1007/s00125-016-4149-3 ) provides further support for the relationship between mild degrees of iron overload and the risk of gestational diabetes. The purpose of this commentary is to briefly discuss the background of this relationship and the implications it may have for routine pregnancy care...
December 9, 2016: Diabetologia
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