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https://www.readbyqxmd.com/read/29785558/differences-between-first-generation-and-second-generation-drug-eluting-stent-regarding-in-stent-neoatherosclerosis-characteristics-an-optical-coherence-tomography-analysis
#1
Norihiro Kobayashi, Yoshiaki Ito, Masahiro Yamawaki, Motoharu Araki, Tsuyoshi Sakai, Masaru Obokata, Yasunari Sakamoto, Shinsuke Mori, Masakazu Tsutsumi, Masahiro Nauchi, Yohsuke Honda, Takahiro Tokuda, Kenji Makino, Shigemitsu Shirai, Keisuke Hirano
We compared first-generation and second-generation drug-eluting stent (DES) with respect to neoatherosclerosis using optical coherence tomography or optical frequency domain imaging. In-stent restenoses in 102 first-generation and 114 second-generation DES were retrospectively assessed. Neoatherosclerosis, which was defined as the presence of lipid-laden neointima or calcification inside a stent, was observed in 33 (27.2%) and 31 (32.4%) lesions in the first-generation and second-generation DES respectively...
May 21, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29781047/a-survey-on-coronary-atherosclerotic-plaque-tissue-characterization-in-intravascular-optical-coherence-tomography
#2
REVIEW
Alberto Boi, Ankush D Jamthikar, Luca Saba, Deep Gupta, Aditya Sharma, Bruno Loi, John R Laird, Narendra N Khanna, Jasjit S Suri
PURPOSE OF REVIEW: Atherosclerotic plaque deposition within the coronary vessel wall leads to arterial stenosis and severe catastrophic events over time. Identification of these atherosclerotic plaque components is essential to pre-estimate the risk of cardiovascular disease (CVD) and stratify them as a high or low risk. The characterization and quantification of coronary plaque components are not only vital but also a challenging task which can be possible using high-resolution imaging techniques...
May 21, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29736635/effect-of-distal-thickening-and-stiffening-of-plaque-cap-on-arterial-wall-mechanics
#3
Pengsrorn Chhai, Kyehan Rhee
To investigate the effect of longitudinal variations of cap thickness and tissue properties on wall stresses and strains along the atherosclerotic stenosis, stenotic plaque models (uniformly thick, distally thickened, homogenous, and distally stiffened) were constructed and subjected to computational stress analyses with due consideration of fluid-structure interactions (FSI). The analysis considered three different cap thicknesses-45, 65, and 200 μm-and tissue properties-soft, fibrous, and hard. The maximum peak cap stress (PCS) and strain were observed in the upstream throat section and demonstrated increases of the order of 345 and 190%, respectively, as the cap thickness was reduced from 200 to 45 μm in uniformly thick models...
May 8, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29729869/plasma-trimethylamine-n-oxide-is-associated-with-vulnerable-plaque-characteristics-in-cad-patients-as-assessed-by-optical-coherence-tomography
#4
Xinxin Liu, Zulong Xie, Meng Sun, Xuedong Wang, Ji Li, Jinjin Cui, Fengyun Zhang, Li Yin, Dan Huang, Jingbo Hou, Jinwei Tian, Bo Yu
BACKGROUND: Plaque vulnerability indicates the risk of a cardiovascular event. In the present study, we sought to analyze the relationship between trimethylamine N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, and vulnerable plaque characteristics in patients with coronary artery disease (CAD). METHODS: One hundred eighty non-culprit plaques from 90 patients with ACS or with stable angina were assessed by optical coherence tomography (OCT)...
April 28, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29704490/mathematical-modeling-of-atherosclerotic-plaque-destabilization-role-of-neovascularization-and-intraplaque-hemorrhage
#5
Muyi Guo, Yan Cai, Xinke Yao, Zhiyong Li
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation with plaque destabilization for the quantitative evaluation of the role of neoangiogenesis and IPH in the vulnerable atherosclerotic plaque formation. An angiogenic microvasculature is generated by two-dimensional nine-point discretization of endothelial cell proliferation and migration from the vasa vasorum...
April 25, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29684365/leucocyte-dynamics-during-the-evolution-of-human-coronary-atherosclerosis-conclusions-from-a-7-fold-chromogen-based-immunohistochemical-evaluation
#6
Melissa Zuiderwijk, Marlieke Geerts, Connie Janssen van Rhijn, Antoon van den Bogaerdt, Jaap F Hamming, Rogier A van Dijk, Jan H Lindeman
Atherosclerosis is a complex process with strong inflammatory component. We developed a straightforward 7-fold staining protocol for simultaneous assessment of dominant leucocyte classes, vascularization, and expression of the putative foam cell maker CD36. The method was applied on human coronaries covering the full spectrum of atherosclerotic disease. Results confirm the progressive association of macrophages and T-cells with the process, and a global presence of mast cells. B-cells exclusively present in adventitial follicles that accompany the process plaque destabilization (thin cap and ruptured lesions) and are otherwise absent...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29679496/detection-of-bone-marrow-derived-fibrocytes-in-human-dental-pulp-repair
#7
N Yoshiba, N Edanami, A Tohma, R Takeuchi, N Ohkura, A Hosoya, Y Noiri, H Nakamura, K Yoshiba
AIM: To explore the expression profile of CD45+/pro-collagen I+ fibrocytes in intact dental pulps as well as during wound healing in adult dental pulp tissue. METHODOLOGY: A total of 16 healthy permanent teeth were obtained from young patients (18 to 25 years) undergoing orthodontic treatment. Routine pulp capping with mineral trioxide aggregate (MTA) was performed under local anaesthesia to induce a mineralized barrier at the exposed surface. Teeth were extracted from patients after 7, 14, and 35 days...
April 21, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29672788/neutrophil-extracellular-traps-participate-in-all-different-types-of-thrombotic-and-haemorrhagic-complications-of-coronary-atherosclerosis
#8
Kartika R Pertiwi, Allard C van der Wal, Dara R Pabittei, Claire Mackaaij, Marinus B van Leeuwen, Xiaofei Li, Onno J de Boer
Acute coronary syndromes can be initiated by either atherosclerotic fibrous cap ruptures, superficial plaque erosions or intraplaque haemorrhages (IPHs). Since neutrophil extracellular traps (NETs) display pro-inflammatory and pro-thrombotic properties, we investigated the presence, extent and distribution of neutrophils and NETs in different types of plaque complications in relation to the age of overlying thrombus mass or haemorrhage. Sixty-four paraffin-embedded coronary plaque segments of 30 acute myocardial infarction patients were retrieved from the autopsy archives, which contained 44 complicated plaques (17 IPHs, 9 erosions and 18 ruptures) and 20 intact plaques...
April 19, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29669957/association-of-age-and-size-of-carotid-artery-intraplaque-hemorrhage-and-minor-fibrous-cap-disruption-a-high-resolution-magnetic-resonance-imaging-study
#9
Yuanyuan Cui, Huiyu Qiao, Lu Ma, Mingming Lu, Jiafei Yang, Guoen Yao, Jianming Cai, Xihai Zhao
AIM: To investigate the association between the volumes of different aging intraplaque hemorrhage (IPH) and minor fibrous cap disruption (MFCD) in carotid arteries. METHODS: Patients with cerebrovascular symptoms and carotid atherosclerotic plaques determined by ultrasound were recruited and underwent multi-contrast magnetic resonance (MR) vessel wall imaging for carotid arteries. Carotid plaques with IPH on MR imaging were included in the analysis. The age (fresh or recent) and the volume of IPH for each plaque were evaluated...
April 17, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29660488/changes-in-the-radicular-pulp-dentine-complex-in-healthy-intact-teeth-and-in-response-to-deep-caries-or-restorations-a-histological-and-histobacteriological-study
#10
Domenico Ricucci, Simona Loghin, Li-Na Niu, Franklin R Tay
INTRODUCTION: The present study reported the histological events that occurred in the radicular pulp of human mature teeth in the presence of medium/deep untreated caries lesions, and those teeth with restorations or direct pulp capping, with particular emphasis on the morphology of the canal wall dentine and the odontoblast layer. METHODS: Sixty-two teeth with medium/deep caries lesions, extensive restorations or after application of a direct pulp capping procedure were obtained from 57 subjects...
April 13, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29616625/plaque-burden-influences-accurate-classification-of-fibrous-cap-atheroma-by-in-vivo-optical-coherence-tomography-in-a-porcine-model-of-advanced-coronary-atherosclerosis
#11
Christian B Poulsen, Ryan M Pedrigi, Nilesh Pareek, Ismail D Kilic, Niels Ramsing Holm, Jacob F Bentzon, Hans Erik Bøtker, Erling Falk, Rob Krams, Ranil de Silva
AIMS: In-vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We investigated this in a porcine model with human-like coronary atherosclerosis. METHODS AND RESULTS: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolemic mini-pigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29578470/development-of-asymmetric-stent-for-treatment-of-eccentric-plaque
#12
Achmad Syaifudin, Ryo Takeda, Katsuhiko Sasaki
The selection of stent and balloon type is decisive in the stenting process. In the treatment of an eccentric plaque obstruction, a symmetric expansion from stent dilatation generates nonuniform stress distribution, which may aggravate fibrous cap prone to rupture. This paper developed a new stent design to treat eccentric plaque using structural transient dynamic analysis in ANSYS. A non-symmetric structural geometry of stent is generated to obtain reasonable stress distribution safe for the arterial layer surrounding the stent...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29572319/ossabaw-pigs-with-a-pcsk9-gain-of-function-mutation-develop-accelerated-coronary-atherosclerotic-lesions-a-novel-model-for-preclinical-studies
#13
Fang Yuan, Liang Guo, Kyoung-Ha Park, John R Woollard, Kwon Taek-Geun, Kai Jiang, Tamene Melkamu, Bin Zang, Samantha L Smith, Scott C Fahrenkrug, Frank D Kolodgie, Amir Lerman, Renu Virmani, Lilach O Lerman, Daniel F Carlson
BACKGROUND: Ossabaw pigs are unique miniature swine with genetic predisposition to develop metabolic syndrome and coronary atherosclerosis after extended periods receiving atherogenic diets. We have hypothesized that transgenic Ossabaw swine expressing chimp PCSK9 (proprotein convertase subtilisin-like/kexin type 9) containing the D374Y gain of function would develop familial hypercholesterolemia and coronary artery plaques more rapidly than Landrace swine with the same transgene. METHODS AND RESULTS: Ossabaw and Landrace PCSK9 gain-of-function founders were generated by Sleeping Beauty transposition and cloning...
March 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29568764/correlation-of-serum-uric-acid-levels-with-nonculprit-plaque-instability-in-patients-with-acute-coronary-syndromes-a-3-vessel-optical-coherence-tomography-study
#14
Donghui Zhang, Ruoxi Zhang, Ning Wang, Lin Lin, Bo Yu
Elevated serum uric acid (SUA) level is known to be a prognostic factor in patients with acute coronary syndrome (ACS). However, the correlation between SUA level and coronary plaque instability has not been fully evaluated. The aim of this study was to investigate the association between SUA level and plaque instability of nonculprit lesions in patients with ACS using optical coherence tomography. A total of 150 patients with ACS who underwent 3-vessel optical coherence tomography were selected. Patients were classified into 3 groups according to tertiles of SUA level...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29508375/effect-of-interstitial-fluid-flow-on-drug-coated-balloon-delivery-in-a-patient-specific-arterial-vessel-with-heterogeneous-tissue-composition-a-simulation-study
#15
Sarifuddin, Prashanta Kumar Mandal
Angioplasty with drug-coated balloons (DCBs) using excipients as drug carriers is emerging as a potentially viable strategy demonstrating clinical efficacy and proposing additional compliance for the treatment of obstructive vascular diseases. An attempt is made to develop an improved computational model where attention has been paid to the effect of interstitial flow, that is, plasma convection and internalization of bound drug. The present model is capable of capturing the phenomena of the transport of free drug and its retention, and also the internalization of drug in the process of endocytosis to atherosclerotic vessel of heterogeneous tissue composition comprising of healthy tissue, as well as regions of fibrous cap, fibro-fatty, calcified and necrotic core lesions...
March 5, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29503197/local-delivery-of-mir-21-stabilizes-fibrous-caps-in-vulnerable-atherosclerotic-lesions
#16
Hong Jin, Daniel Y Li, Ekaterina Chernogubova, Changyan Sun, Albert Busch, Suzanne M Eken, Peter Saliba-Gustafsson, Hanna Winter, Greg Winski, Uwe Raaz, Isabel N Schellinger, Nancy Simon, Renate Hegenloh, Ljubica Perisic Matic, Maja Jagodic, Ewa Ehrenborg, Jaroslav Pelisek, Hans-Henning Eckstein, Ulf Hedin, Alexandra Backlund, Lars Maegdefessel
miRNAs are potential regulators of carotid artery stenosis and concordant vulnerable atherosclerotic plaques. Hence, we analyzed miRNA expression in laser captured micro-dissected fibrous caps of either ruptured or stable plaques (n = 10 each), discovering that miR-21 was significantly downregulated in unstable lesions. To functionally evaluate miR-21 in plaque vulnerability, miR-21 and miR-21/apolipoprotein-E double-deficient mice (Apoe-/- miR-21-/- ) were assessed. miR-21-/- mice lacked sufficient smooth muscle cell proliferation in response to carotid ligation injury...
April 4, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29496659/inhibition-of-local-macrophage-growth-ameliorates-focal-inflammation-and-suppresses-atherosclerosis
#17
Sarie Yamada, Takafumi Senokuchi, Takeshi Matsumura, Yutaro Morita, Norio Ishii, Kazuki Fukuda, Saiko Murakami-Nishida, Shuhei Nishida, Shuji Kawasaki, Hiroyuki Motoshima, Noboru Furukawa, Yoshihiro Komohara, Yukio Fujiwara, Tomoaki Koga, Kazuya Yamagata, Motohiro Takeya, Eiichi Araki
OBJECTIVE: Macrophages play a central role in various stages of atherosclerotic plaque formation and progression. The local macrophages reportedly proliferate during atherosclerosis, but the pathophysiological significance of macrophage proliferation in this context remains unclear. Here, we investigated the involvement of local macrophage proliferation during atherosclerosis formation and progression using transgenic mice, in which macrophage proliferation was specifically suppressed...
May 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29480622/primordial-odontogenic-tumor-subepithelial-expression-of-syndecan-1-and-ki-67-suggests-origin-during-early-odontogenesis
#18
R Bologna-Molina, T Mikami, V Pereira-Prado, G Tapia-Repetto, F R Pires, R Carlos, A Mosqueda-Taylor
Primordial odontogenic tumor (POT) is composed of variably cellular myxoid connective tissue, surrounded by cuboidal to columnar odontogenic epithelium resembling the inner epithelium of the enamel organ, which often invaginates into the underlying connective tissue. The tumor is delimited at least partially by a thin fibrous capsule. It derives from the early stages of tooth development. Syndecan-1 is a heparan sulfate proteoglycan that has a physiological role in several cellular functions, including maintenance of the epithelial architecture, cell-to-cell adhesion and interaction of cells with extracellular matrix, and with diverse growth factors, stimulating cell proliferation...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29479763/diagnostic-accuracy-of-a-clinical-carotid-plaque-mr-protocol-using-a-neurovascular-coil-compared-to-a-surface-coil-protocol
#19
Waleed Brinjikji, J Kevin DeMarco, Robert Shih, Giuseppe Lanzino, Alejandro A Rabinstein, Christopher A Hilditch, Patrick J Nicholson, John Huston
BACKGROUND: Carotid plaque imaging with MRI is becoming more commonplace, but practical challenges exist in performing plaque imaging with surface coils. PURPOSE: To compare the diagnostic performance of a carotid plaque MRI protocol using a standard neurovascular coil (Neurovascular Coil Protocol) to a higher-resolution carotid plaque MRI using carotid surface coils (Surface Coil Protocol) in characterizing carotid plaque. STUDY TYPE: Prospective study comparing two MR techniques in plaque characterization...
February 25, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29407600/impact-of-cd14-cd16-monocytes-on-coronary-plaque-vulnerability-assessed-by-optical-coherence-tomography-in-coronary-artery-disease-patients
#20
Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
BACKGROUND AND AIMS: This study examined the impact of CD14++ CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++ CD16+ monocyte levels have been reported to increase cardiovascular events, their impact on coronary plaque vulnerability in coronary artery disease (CAD) patients with or without diabetes mellitus (DM) remains unclear. METHODS: This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT...
February 2018: Atherosclerosis
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