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https://www.readbyqxmd.com/read/29929185/spectral-domain-optical-coherence-tomography-allows-the-unification-of-clinical-decision-making-for-the-evaluation-of-choroidal-neovascularization-activity
#1
Cornelia Volz, Felix Grassmann, Roman Greslechner, David Arthur Märker, Patrick Peters, Horst Helbig, Maria-Andreea Gamulescu
PURPOSE: This prospective observational clinical study investigated the benefits of spectral domain optical coherence tomography for specialists and residents in the management of neovascular age-related macular degeneration (AMD). PROCEDURES: The study involved 49 eyes of 44 patients. Patients were advised to present for reevaluation 4 weeks after the administration of the loading dose of vascular endothelial growth factor (VEGF)-inhibitors (3 intravitreal injections every 4 weeks after diagnosis)...
June 21, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29928402/overexpression-of-%C3%AE-3-%C3%AE-3-and-%C3%AE-2-chains-of-laminin-332-is-associated-with-poor-prognosis-in-pancreatic-ductal-adenocarcinoma
#2
Jun Chen, Hao Zhang, Jiansheng Luo, Xiaokang Wu, Xueming Li, Xinyi Zhao, Dongkai Zhou, Shian Yu
Pancreatic ductal adenocarcinoma (PDA) is a worldwide health problem. Early diagnosis and assessment may enhance the quality of life and survival of patients. The present study investigated the potential correlations between the gene and protein expression of laminin-332 (LM-332 or laminin-5) and clinicopathological factors as well as evaluating its influence on the survival of patients with PDA. The expression of LM-332 subunit mRNAs in pancreatic carcinoma specimens from 37 patients was investigated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29927906/interval-since-last-hiv-test-for-men-and-women-with-recent-risk-for-hiv-infection-united-states-2006-2016
#3
Marc A Pitasi, Kevin P Delaney, Emeka Oraka, Heather Bradley, Elizabeth A DiNenno, John T Brooks, Joseph Prejean
Since 2006, CDC has recommended routine screening of all persons aged 13-64 years for human immunodeficiency virus (HIV) and at least annual rescreening of persons at higher risk (1). However, national surveillance data indicate that many persons at higher risk for HIV infection are not screened annually, and delays in diagnosis persist (2). CDC analyzed 2006-2016 data from the General Social Survey (GSS)* and estimated that only 39.6% of noninstitutionalized U.S. adults had ever tested for HIV. Among persons ever tested, the estimated median interval since last test was 1,080 days or almost 3 years...
June 22, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29927782/is-the-time-between-first-diagnosis-of-paroxysmal-atrial-fibrillation-and-cryoballoon-ablation-a-predictor-of-efficacy
#4
Maurizio Lunati, Giuseppe Arena, Saverio Iacopino, Roberto Verlato, Claudio Tondo, Antonio Curnis, Stefano Porcellini, Luigi Sciarra, Giulio Molon, Gaetano Senatore, Loira Leoni, Giovanni Battista Perego, Werner Rauhe, Patrizia Pepi, Maurizio Landolina
AIMS: Cryoablation is an indicated therapy for the treatment of recurrent atrial fibrillation through pulmonary vein isolation; however, the optimal time between first diagnosis of atrial fibrillation and cryoablation is still unknown. We aimed to assess the clinical efficacy and safety of early versus later treatment of patients with paroxysmal atrial fibrillation by cryoablation. METHODS: Five hundred and ten patients underwent atrial fibrillation cryoablation and were prospectively followed for at least 6 months in 43 Italian cardiology centers...
June 20, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29927013/depressive-symptoms-in-relation-to-overall-survival-in-people-with-head-and-neck-cancer-a-longitudinal-cohort-study
#5
Femke Jansen, Irma M Verdonck-de Leeuw, Pim Cuijpers, C René Leemans, Tim Waterboer, Michael Pawlita, Chris Penfold, Steven J Thomas, Andrea Waylen, Andrew R Ness
OBJECTIVE: To investigated the relation between pre-treatment depressive symptoms (DS) and the course of DS during the first year after cancer diagnosis, and overall survival among people with head and neck cancer (HNC). METHODS: Data from the Head and Neck 5000 prospective clinical cohort study were used. DS were measured using the Hospital Anxiety and Depression Scale (HADS) pre-treatment, at 4 and 12 months follow-up. Also socio-demographic, clinical, lifestyle and mortality data were collected...
June 21, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29927010/treatment-patterns-and-health-care-resource-use-in-patients-receiving-multiple-lines-of-therapy-for-metastatic-squamous-cell-carcinoma-of-the-head-and-neck-in-the-united-kingdom
#6
Elizabeth M La, Emily Nash Smyth, Sandra E Talbird, Li Li, James A Kaye, Aimee Bence Lin, Lee Bowman
This study evaluated the patterns of care and health care resource use (HCRU) in patients with metastatic squamous cell carcinoma of the head and neck (SCCHN) who received ≥3 lines of systemic therapy in the United Kingdom (UK). Oncologists (n = 40) abstracted medical records for patients with metastatic SCCHN who initiated third-line systemic therapy during 1 January 2011-30 August 2014 (n = 220). Patient characteristics, treatment patterns and SCCHN-related HCRU were summarised descriptively for the metastatic period; exploratory multivariable regression analyses were conducted on select HCRU outcomes...
June 21, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29926947/classification-and-diagnosis-of-aggressive-periodontitis
#7
Daniel H Fine, Amey G Patil, Bruno G Loos
OBJECTIVE: Since the initial description of aggressive periodontitis (AgP) in the early 1900s, classification of this disease has been in flux. The goal of this manuscript is to review the existing literature and to revisit definitions and diagnostic criteria for AgP. STUDY ANALYSIS: An extensive literature search was performed that included databases from PubMed, Medline, Cochrane, Scopus and Web of Science. Of 4930 articles reviewed, 4737 were eliminated. Criteria for elimination included; age > 30 years old, abstracts, review articles, absence of controls, fewer than; a) 200 subjects for genetic studies, and b) 20 subjects for other studies...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926943/periodontal-manifestations-of-systemic-diseases-and-developmental-and-acquired-conditions-consensus-report-of-workgroup-3-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#8
Søren Jepsen, Jack G Caton, Jasim M Albandar, Nabil F Bissada, Philippe Bouchard, Pierpaolo Cortellini, Korkud Demirel, Massimo de Sanctis, Carlo Ercoli, Jingyuan Fan, Nicolaas C Geurs, Francis J Hughes, Lijian Jin, Alpdogan Kantarci, Evanthia Lalla, Phoebus N Madianos, Debora Matthews, Michael K McGuire, Michael P Mills, Philip M Preshaw, Mark A Reynolds, Anton Sculean, Cristiano Susin, Nicola X West, Kazuhisa Yamazaki
BACKGROUND: A variety of systemic diseases and conditions can affect the course of periodontitis or have a negative impact on the periodontal attachment apparatus. Gingival recessions are highly prevalent and often associated with hypersensitivity, the development of caries and non-carious cervical lesions on the exposed root surface and impaired esthetics. Occlusal forces can result in injury of teeth and periodontal attachment apparatus. Several developmental or acquired conditions associated with teeth or prostheses may predispose to diseases of the periodontium...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926500/periodontal-manifestations-of-systemic-diseases-and-developmental-and-acquired-conditions-consensus-report-of-workgroup-3-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#9
Søren Jepsen, Jack G Caton, Jasim M Albandar, Nabil F Bissada, Philippe Bouchard, Pierpaolo Cortellini, Korkud Demirel, Massimo de Sanctis, Carlo Ercoli, Jingyuan Fan, Nicolaas C Geurs, Francis J Hughes, Lijian Jin, Alpdogan Kantarci, Evanthia Lalla, Phoebus N Madianos, Debora Matthews, Michael K McGuire, Michael P Mills, Philip M Preshaw, Mark A Reynolds, Anton Sculean, Cristiano Susin, Nicola X West, Kazuhisa Yamazaki
BACKGROUND: A variety of systemic diseases and conditions can affect the course of periodontitis or have a negative impact on the periodontal attachment apparatus. Gingival recessions are highly prevalent and often associated with hypersensitivity, the development of caries and non-carious cervical lesions on the exposed root surface and impaired esthetics. Occlusal forces can result in injury of teeth and periodontal attachment apparatus. Several developmental or acquired conditions associated with teeth or prostheses may predispose to diseases of the periodontium...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29926487/classification-and-diagnosis-of-aggressive-periodontitis
#10
Daniel H Fine, Amey G Patil, Bruno G Loos
OBJECTIVE: Since the initial description of aggressive periodontitis (AgP) in the early 1900s, classification of this disease has been in flux. The goal of this manuscript is to review the existing literature and to revisit definitions and diagnostic criteria for AgP. STUDY ANALYSIS: An extensive literature search was performed that included databases from PubMed, Medline, Cochrane, Scopus and Web of Science. Of 4930 articles reviewed, 4737 were eliminated. Criteria for elimination included; age > 30 years old, abstracts, review articles, absence of controls, fewer than; a) 200 subjects for genetic studies, and b) 20 subjects for other studies...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29925574/improving-guideline-based-streptococcal-pharyngitis-testing-a-quality-improvement-initiative
#11
Laura E Norton, Brian R Lee, Lory Harte, Keith Mann, Jason G Newland, R Alan Grimes, Angela L Myers
BACKGROUND AND OBJECTIVES: Acute pharyngitis is a common diagnosis in ambulatory pediatrics. The Infectious Diseases Society of America (IDSA) clinical practice guideline for group A streptococcal (GAS) pharyngitis recommends strict criteria for GAS testing to avoid misdiagnosis and unnecessary treatment of children who are colonized with group A Streptococcus . We sought to improve adherence to the IDSA guideline for testing and treatment of GAS pharyngitis in a large community pediatrics practice...
June 20, 2018: Pediatrics
https://www.readbyqxmd.com/read/29925512/detailed-genetic-characteristics-of-an-international-large-cohort-of-patients-with-stargardt-disease-progstar-study-report-8
#12
Kaoru Fujinami, Rupert W Strauss, John Pei-Wen Chiang, Isabelle S Audo, Paul S Bernstein, David G Birch, Samantha M Bomotti, Artur V Cideciyan, Ann-Margret Ervin, Meghan J Marino, José-Alain Sahel, Saddek Mohand-Said, Janet S Sunness, Elias I Traboulsi, Sheila West, Robert Wojciechowski, Eberhart Zrenner, Michel Michaelides, Hendrik P N Scholl
BACKGROUND/AIMS: To describe the genetic characteristics of the cohort enrolled in the international multicentre progression of Stargardt disease 1 (STGD1) studies (ProgStar) and to determine geographic differences based on the allele frequency. METHODS: 345 participants with a clinical diagnosis of STGD1 and harbouring at least one disease-causing ABCA4 variant were enrolled from 9 centres in the USA and Europe. All variants were reviewed and in silico analysis was performed including allele frequency in public databases and pathogenicity predictions...
June 20, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29925495/the-impact-of-implementation-of-a-clinically-integrated-problem-based-neonatal-electronic-health-record-on-documentation-metrics-provider-satisfaction-and-hospital-reimbursement-a-quality-improvement-project
#13
William Liu, Thomas Walsh
BACKGROUND: A goal of effective electronic health record provider documentation platforms is to provide an efficient, concise, and comprehensive notation system that will effectively reflect the clinical course, including the diagnoses, treatments, and interventions. OBJECTIVE: The aim is to fully redesign and standardize the provider documentation process, seeking improvement in documentation based on ongoing All Patient Refined Diagnosis Related Group-based coding records, while maintaining noninferiority comparing provider satisfaction to our existing documentation process...
June 20, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29925338/prevalence-of-psychiatric-diagnoses-in-asylum-seekers-with-follow-up
#14
Kneginja Richter, Lukas Peter, Hartmut Lehfeld, Harald Zäske, Salina Brar-Reissinger, Günter Niklewski
BACKGROUND: In the study, the frequency and nature of asylum seekers' psychiatric diagnoses in a German admission center were examined. Additional aims were to identify changes in those diagnoses over time and to investigate health care utilization of mentally ill asylum seekers in the community. METHODS: The sample for the study "Psychiatric Examination of Asylum Seekers" in Bavaria consisted of a total of 283 asylum seekers and included 2 subsamples: help-seeking individuals and a randomly selected group...
June 20, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29925312/a-pilot-and-comparative-study-between-pathological-and-serological-levels-of-immunoglobulin-and-complement-among-three-kinds-of-primary-glomerulonephritis
#15
Jin Dong, Tianhao Peng, Jing Gao, Xingwang Jia, Guangtao Yan, Yong Wang
BACKGROUND: Immunoglobulin A nephropathy (IgAN), membranous nephropathy (MN) and minimal-change disease (MCD) are three common types of glomerulonephritis in China. Pathological diagnosis based on renal biopsy is the criterion and the golden standard for diagnosing the sub-types of primary or secondary glomerulonephritis. Immunoglobulin and complements might be used in the differential diagnosis of glomerulonephritis without renal biopsies. However, the relationship between IF intensities of immune proteins and the corresponding serum levels remained unclear, and seldom studies combine histopathological examination results and blood tests together for a predictive purpose...
June 20, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29925280/role-of-some-circulating-mirnas-on-breast-cancer-diagnosis
#16
Menha Swellam, Rasha F K Zahran, Hossam Abo El-Sadat Taha, Nashwa El-Khazragy, Camelia Abdel-Malak
Aberrant expression of miRNAs has a link with tumorgenesis and their deregulation is reported in biological fluids of cancer patients. Authors aimed to investigate the diagnostic role of miRNA-17-5p, miR-155 and miRNA-222 in serum samples from breast cancer patients (n = 80), benign breast patients (n = 40) and healthy individuals (n = 30) using quantitative real-time PCR technique. Median levels of investigated markers revealed significant increase in primary breast cancer followed by benign and control groups...
June 20, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29925179/-myocardial-amyloid-deposition-in-patients-aged-over-85-years-with-heart-failure-and-preserved-ejection-fraction
#17
Y Y Li, W R Zhu, K Chai, J F Yang, F Fang, S R He, C Q Yang, H Wang
Objective: To determine the frequency and extent of left ventricular amyloid deposition in patients aged over 85 years with heart failure and preserved ejection fraction (HFpEF). Methods: A total of 43 patients aged 85 to 100 years old were enrolled in this study based on the autopsy database of Beijing Hospital from February 1, 2003 to October 31, 2016. The frequency and extent of left ventricular amyloid deposition and myocardial fibrosis were determined in left ventricular specimens from patients with antemortem diagnosis of HFpEF without clinically apparent amyloid ( n= 28) and from control subjects ( n= 15) post Congo red staining and Masson's trichrome staining...
June 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29924663/emergency-department-visits-by-adolescent-and-young-adult-cancer-patients-compared-with-pediatric-cancer-patients-in-the-united-states
#18
Sapna Kaul, Heidi Russell, John A Livingston, Anne C Kirchhoff, Daniel Jupiter
PURPOSE: Limited information exists on emergency department (ED) visits for adolescent and young adult (AYA) patients with cancer. We examined the clinical reasons for ED visits, and outcomes, for AYAs with cancer compared to pediatric cancer patients. METHODS: The 2013 Nationwide Emergency Department Sample data were used to identify 53,274 AYA (ages 15-39) and 6952 pediatric (ages 0-14) cancer ED visits. We evaluated patient (i.e., demographic and diagnosis) and hospital characteristics, and the ED event outcome (admitted to the same hospital or treated/released)...
June 20, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29924374/acute-care-hospitalizations-for-mental-and-behavioural-disorders-among-first-nations-people
#19
Gisèle Carrière, Bougie Bougie, Dafna Kohen
BACKGROUND: National information about acute care hospitalizations for mental/behavioural disorders among Aboriginal people in Canada is limited. DATA AND METHODS: This study describes acute care hospitalizations for mental /behavioural disorders among First Nations people living on and off reserve. The 2006 Census was linked to the Discharge Abstract Database from 2006/2007 through 2008/2009 for all provinces (except Ontario and Quebec) and the three territories...
June 20, 2018: Health Reports
https://www.readbyqxmd.com/read/29923991/optimal-combination-of-treatment-modality-to-increase-survival-in-patients-with-anaplastic-thyroid-carcinoma-a-strobe-compliant-retrospective-study
#20
Joon-Hyop Lee, Hee Kyung Ahn, Jae Yeon Seok, Kyu-Chan Lee, Yong Soon Chun, Yoo Seung Chung, Young Don Lee
There is little consensus on the optimal treatment approach for newly diagnosed patients. The present study aims to provide additional evidence by evaluating a series of patients diagnosed with anaplastic thyroid carcinoma (ATC) and analyzing factors related to increased survival. This was a retrospective cohort report structured according to the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) guideline. Demographics, chief complaint, history of prior thyroid cancer, stage at presentation, management modalities (surgery, chemotherapy, radiotherapy, or observation), completeness or resection, and survival period since initial diagnosis were reviewed for patients with documentation of histologic ATC diagnosis between 2003 and 2016...
June 2018: Medicine (Baltimore)
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