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CKD, lung

Shih-Yi Lin, Cheng-Li Lin, Chao-Hsiang Chang, His-Chin Wu, Wen-Chi Chen, I-Kuan Wang, Yao Lung Liu, Fung-Chang Sung, Yen-Jung Chang, Chia-Hung Kao
Large cohort studies on whether any association existed between urological interventions for urolithiasis and the development of CKD are lacking. From claims data of the National Health Insurance (NHI) program of Taiwan, we identified 54,433 patients newly diagnosed with urolithiasis during 1998-2010. For each case, four individuals without urolithiasis were randomly selected and frequency matched by age, sex, and diagnosis year. Both groups were followed up until the end of 2010. Incident CKD events were identified by the International Classification of Diseases, Ninth Revision (ICD-9) code in the NHI registration database...
October 19, 2016: Urolithiasis
Fabio Rosario Salerno, Grace Parraga, Christopher William McIntyre
Dyspnea is one of the most common symptoms associated with CKD. It has a profound influence on the quality of life of CKD patients, and its underlying causes are often associated with a negative prognosis. However, its pathophysiology is poorly understood. While hemodialysis may address fluid overload, it often does not significantly improve breathlessness, suggesting multiple and co-existing alternative issues exist. The aim of this article is to discuss the main pathophysiologic mechanisms and the most important putative etiologies underlying dyspnea in CKD patients...
September 28, 2016: Seminars in Dialysis
Daniela Verzola, Francesca Ansaldo, Samantha Milanesi, Emanuele Luigi Parodi, Gian Marco Rosa, Antonella Sofia, Alice Bonanni, Francesca Viazzi, Manrico Balbi, Giacomo Garibotto
Fibroblast Growth Factor-23 (FGF-23) accumulates in blood of patients with chronic kidney disease (CKD) and is associated both with cardiovascular complications and disease progression. However, our knowledge of the sites and mechanisms which regulate plasma FGF-23 is still incomplete. We measured plasma intact FGF-23 across the kidney, splanchnic organs and lung in eleven patients (eGFR 60 ± 6 ml/min) during elective diagnostic cardiac catheterizations. In these patients FGF-23 was removed by the kidney, with a fractional extraction (FE) of ~22%...
August 24, 2016: American Journal of Physiology. Renal Physiology
Valeria Mastrilli, Roberto D'Elia, Daniela Galeone
The Prevention of Chronic Kidney Disease (CKD) is placed in the more general context of prevention of major chronic Non Communicable Diseases (NCDs): cardiovascular diseases, diabetes, chronic lung diseases and tumors that are the main problem for public health worldwide. Any health policy strategy aimed to the prevention of NCDs has to provide knowledge of health and socioeconomic status of the population, to reduce the level of exposure to risk factors and to adapt health services to the request for assistance...
July 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Hui-Ting Wang, Yung-Lung Chen, Chiung-Jen Wu
BACKGROUND: Patients with chronic kidney disease (CKD) experience poor outcomes after acute myocardial infarction. This study investigated how CKD affects clinical outcomes in patients with non-ST segment elevation myocardial infarction (NSTEMI) receiving PCI. METHODS: This retrospective study analyzed record-linked data for 314 patients who had received PCI for NSTEMI between January 2008 and September 2010. The 141 patients with advanced CKD were compared with 173 patients who had mild or no CKD...
October 1, 2016: International Journal of Cardiology
Masaaki Konishi, Junichi Ishida, Jochen Springer, Stefan D Anker, Stephan von Haehling
Even though most clinical data on cachexia have been reported from Western countries, cachexia may be a growing problem in Asia as well, as the population in this area of the world is considerably larger. Considering the current definitions of obesity and sarcopenia in Japan, which are different from the ones in Western countries, the lack of a distinct cachexia definition in Japan is strinking. Only one epidemiological study has reported the prevalence of cachexia using weight loss as part of the definition in patients with stage III or IV non-small cell lung cancer...
April 12, 2016: Journal of Cachexia, Sarcopenia and Muscle
Jianmin Chen, Julius E Kieswich, Fausto Chiazza, Amie J Moyes, Thomas Gobbetti, Gareth S D Purvis, Daniela C F Salvatori, Nimesh S A Patel, Mauro Perretti, Adrian J Hobbs, Massimo Collino, Muhammad M Yaqoob, Christoph Thiemermann
Patients with CKD requiring dialysis have a higher risk of sepsis and a 100-fold higher mortality rate than the general population with sepsis. The severity of cardiac dysfunction predicts mortality in patients with sepsis. Here, we investigated the effect of preexisting CKD on cardiac function in mice with sepsis and whether inhibition of IκB kinase (IKK) reduces the cardiac dysfunction in CKD sepsis. Male C57BL/6 mice underwent 5/6 nephrectomy, and 8 weeks later, they were subjected to LPS (2 mg/kg) or sepsis by cecal ligation and puncture (CLP)...
May 6, 2016: Journal of the American Society of Nephrology: JASN
Uwe Primessnig, Patrick Schönleitner, Alexander Höll, Susanne Pfeiffer, Taja Bracic, Thomas Rau, Martin Kapl, Tatjana Stojakovic, Toma Glasnov, Kirsten Leineweber, Paulina Wakula, Gudrun Antoons, Burkert Pieske, Frank R Heinzel
AIMS: Heart failure with preserved ejection fraction (HFpEF) is increasingly common, but the underlying cellular mechanisms are not well understood. We investigated cardiomyocyte function and the role of SEA0400, an Na(+) /Ca(2+) exchanger (NCX) inhibitor in a rat model of chronic kidney disease (CKD) with HFpEF. METHODS AND RESULTS: Male Wistar rats were subjected to subtotal nephrectomy (NXT) or sham operation (Sham). After 8 and 24 weeks, in vivo (haemodynamics, echocardiography) and in vitro function (LV cardiomyocyte cell shortening (CS), and Ca(2+) transients (CaT)) were determined without and with SEA0400...
August 2016: European Journal of Heart Failure
Hsin-Chih Yeh, Tsu-Ming Chien, Wen-Jeng Wu, Ching-Chia Li, Wei-Ming Li, Hung-Lung Ke, Yii-Her Chou, Chii-Jye Wang, Shu-Pin Huang, Chien-Feng Li, Peir-In Liang, Chun-Nung Huang
PURPOSE: We aimed to identify the effect of preoperative anemia on oncologic outcomes in patients with upper tract urothelial carcinoma (UTUC) who had different levels of renal function. METHODS: Between 2000 and 2013, we enrolled 370 patients who underwent radical nephroureterectomy for nonmetastatic UTUC. Preoperative anemia was defined as hemoglobin <130g/l in men and <120g/l in women based on the World Health Organization classification. Kaplan-Meier method was applied to estimate the effect anemia on survival, and hazard ratios (HR) of anemia and other clinicopathological parameters were evaluated by Cox regression model...
August 2016: Urologic Oncology
Sankar D Navaneethan, Sreedhar Mandayam, Susana Arrigain, Mahboob Rahman, Wolfgang C Winkelmayer, Jesse D Schold
BACKGROUND: Prevalence and factors associated with obstructive and restrictive lung function in people with chronic kidney disease (CKD) are unknown. STUDY DESIGN: Cross-sectional and longitudinal analyses. SETTING & PARTICIPANTS: Participants aged 40 to 79 years from NHANES (National Health and Nutrition Examination Survey) 2007 to 2012 who underwent spirometry testing. PREDICTOR: CKD (estimated glomerular filtration rate [eGFR] >15-<60mL/min/1...
September 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Natalie Staplin, Richard Haynes, William G Herrington, Christina Reith, Alan Cass, Bengt Fellström, Lixin Jiang, Bertram L Kasiske, Vera Krane, Adeera Levin, Robert Walker, Christoph Wanner, David C Wheeler, Martin J Landray, Colin Baigent, Jonathan Emberson
BACKGROUND: The absolute and relative importance of smoking to vascular and nonvascular outcomes in people with chronic kidney disease (CKD), as well its relevance to kidney disease progression, is uncertain. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: 9,270 participants with CKD enrolled in SHARP. PREDICTOR: Baseline smoking status (current, former, and never). OUTCOMES: Vascular events, site-specific cancer, ESRD, rate of change in estimated glomerular filtration rate (eGFR), and cause-specific mortality...
September 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Yejin Mok, Kunihiro Matsushita, Yingying Sang, Shoshana H Ballew, Morgan Grams, Sang Yop Shin, Sun Ha Jee, Josef Coresh
BACKGROUND: The link of low estimated glomerular filtration rate (eGFR) and high proteinuria to cardiovascular disease (CVD) mortality is well known. However, its link to mortality due to other causes is less clear. METHODS: We studied 367,932 adults (20-93 years old) in the Korean Heart Study (baseline between 1996-2004 and follow-up until 2011) and assessed the associations of creatinine-based eGFR and dipstick proteinuria with mortality due to CVD (1,608 cases), cancer (4,035 cases), and other (non-CVD/non-cancer) causes (3,152 cases) after adjusting for potential confounders...
2016: PloS One
Lung-Sheng Wu, Shang-Hung Chang, Gwo-Jyh Chang, Jia-Rou Liu, Yi-Hsin Chan, Hsin-Fu Lee, Ming-Shien Wen, Wei-Jan Chen, Yung-Hsin Yeh, Chi-Tai Kuo, Lai-Chu See
BACKGROUND: Contemporary guidelines recommend angiotensin-converting-enzyme inhibitors (ACEi) or angiotensin-receptor blockers (ARB) for hypertensive patients with diabetes. However, there is limited data to evaluate the comparison between ACEi and ARB on end stage renal disease (ESRD) and major adverse cardiovascular events (MACE), in Asian diabetic patients. METHODS: We used the Taiwan Longitudinal Cohort of Diabetes Patients Database to perform a population-based dynamic cohort study...
2016: Cardiovascular Diabetology
Kent Doi
Kidney injury, including acute kidney injury (AKI) and chronic kidney disease (CKD), has become very common in critically ill patients treated in ICUs. Many epidemiological studies have revealed significant associations of AKI and CKD with poor outcomes of high mortality and medical costs. Although many basic studies have clarified the possible mechanisms of sepsis and septic AKI, translation of the obtained findings to clinical settings has not been successful to date. No specific drug against human sepsis or AKI is currently available...
2016: Journal of Intensive Care
Chia-Chi Lung, Zhi-Hong Jian, Jing-Yang Huang, Oswald Ndi Nfor
BACKGROUND: Esophageal variceal bleeding (EVB) is a serious and common complication of cirrhosis. Diabetes mellitus (DM) and chronic kidney disease (CKD) increase mortality in patients with cirrhosis. However, whether coexisting DM and CKD increase mortality in cirrhotic patients with EVB remains unclear. METHODS: We enrolled cirrhotic patients hospitalized with the first presentation of EVB from 2005 through 2010 using Longitudinal Health Insurance Database 2005...
2016: BMC Gastroenterology
Yan Xie, Benjamin Bowe, Hong Xian, Sumitra Balasubramanian, Ziyad Al-Aly
BACKGROUND: Multiple prior studies demonstrated that patients with early Chronic Kidney Disease (CKD) and positive estimated Glomerular Filtration Rate (eGFR) slopes experience increased risk of death. We sought to characterize patients with positive eGFR slopes, examine the renal function trajectory that follows the time period where positive slope is observed, and examine the association between different trajectories and risk of death. METHODS AND FINDINGS: We built a cohort of 204,132 United States veterans with early CKD stage 3; eGFR slopes were defined based on Bayesian mixed-effects models using outpatient eGFR measurements between October 1999 and September 2004; to build renal function trajectories, patients were followed longitudinally thereafter (from October 2004) until September 2013...
2016: PloS One
Sankar D Navaneethan, Jesse D Schold, Haiquan Huang, Georges Nakhoul, Stacey E Jolly, Susana Arrigain, Raed A Dweik, Joseph V Nally
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with higher mortality in the general population. We studied the associations between COPD and death among chronic kidney disease (CKD) patients along with reporting cause-specific death data. METHODS: We included 56,960 patients with stages 3 and 4 CKD who were followed in a large health care system. Associations between COPD and all-cause mortality and various causes of death (respiratory deaths, cardiovascular deaths, malignancy-related deaths and deaths due to other reasons) were studied using the Cox proportional hazards and competing risk models...
2016: American Journal of Nephrology
Francesco Marino, Carmela Martorano, Rocco Tripepi, Marianna Bellantoni, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali
In patients with nephrotic syndrome (NS), the lung is considered an organ protected from the risk of edema. However, data on objectively measured lung water in NS patients is lacking. Here we measured lung water by an ultrasound (US) technique as well as by transthoracic impedance in 42 asymptomatic patients with active NS, in 14 stage G5D CKD patients on chronic hemodialysis, and in 21 healthy individuals. In patients with active NS, the median number of US-B lines (a metric of lung water) after 5 min in a supine position was significantly higher (12; interquartile range: 7-25) compared with that in healthy individuals (4; 2-9) but similar to that in hemodialysis patients (23; 10-39)...
February 2016: Kidney International
J Chen, J Kieswich, F Chiazza, T Gobbetti, N S A Patel, M Perretti, M Collino, M M Yaqoob, C Thiemermann
INTRODUCTION: Patients with chronic kidney disease (CKD) requiring dialysis have a higher risk of sepsis and a 100-fold higher mortality. The severity of cardiac dysfunction predicts mortality among septic patients. Here we investigated the roles of pre-existing CKD on the cardiac outcome in mice with sepsis, and whether inhibition of IκB kinase (IKK) reduces the cardiac dysfunction in these animals. METHODS: Male C57BL/6 mice were subjected to 5/6th nephrectomy (SNX) for 8 weeks, and were further subjected to either low dose LPS (2 mg/kg) or cecum ligation and puncture (CLP) (fluid and antibiotics given at 6 h and 18 h)...
October 2015: Shock
Sung-Sheng Tsai, Yu-Sheng Lin, Chia-Pin Lin, Jawl-Shan Hwang, Lung-Sheng Wu, Pao-Hsien Chu
Metabolic syndrome (MS), high-sensitivity C-reactive protein (hs-CRP), and chronic kidney disease (CKD) are related to cardiovascular diseases. Although MS is common in CKD subjects, the contribution of MS-associated risk factors and hs-CRP to arterial stiffness in CKD has not been well studied.In this cross-sectional cohort study, we enrolled 9903 subjects who underwent brachial-ankle pulse wave velocity (baPWV) measurements from our database of Health Care Center. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1...
September 2015: Medicine (Baltimore)
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