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https://www.readbyqxmd.com/read/29220099/supportive-palliative-care-should-be-integrated-into-routine-care-for-paediatric-patients-with-life-limiting-kidney-disease
#1
REVIEW
Julia Thumfart, Tobias Reindl, Cornelia Rheinlaender, Dominik Müller
AIM: Paediatric palliative care is no longer restricted to patients with cancer and has been extended to patients with other chronic conditions, such as cystic fibrosis or neuromuscular disorders. This review focused on the current state of palliative care for children and adolescents with chronic kidney disease (CKD). METHOD: We assessed the literature on CKD published up to August 2017. All the papers, except one from 1996, were published this century. This review discusses the role that palliative care plays in the process of decision-making and explores the possibilities of implementing palliative care into the routine therapy of affected patients and providing support for their families...
December 8, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29212486/emerging-concepts-and-spectrum-of-renal-injury-following-intravesical-bcg-for-non-muscle-invasive-bladder-cancer
#2
Azharuddin Mohammed, Zubair Arastu
BACKGROUND: Intravesical Bacilli Calmette-Guerin (IVBCG) therapy for non-muscle invasive bladder cancer (NMIBC) has long been in use successfully. Albeit rarely, we still face with its safety concerns more than 25 years on since its approval by US Food and Drug Agency in 1990. Local and systemic infection following intravesical BCG is widely reported as compared to immune mediated local or systemic hypersensitivity reactions involving kidneys; acute kidney injury (AKI) and other renal manifestations are well reported but not of chronic kidney disease (CKD)...
December 6, 2017: BMC Urology
https://www.readbyqxmd.com/read/29204651/whole-exome-sequencing-in-adults-with-chronic-kidney-disease-a-pilot-study
#3
Sneh Lata, Maddalena Marasa, Yifu Li, David A Fasel, Emily Groopman, Vaidehi Jobanputra, Hila Rasouly, Adele Mitrotti, Rik Westland, Miguel Verbitsky, Jordan Nestor, Lindsey M Slater, Vivette D'Agati, Marcin Zaniew, Anna Materna-Kiryluk, Francesca Lugani, Gianluca Caridi, Luca Rampoldi, Aditya Mattoo, Chad A Newton, Maya K Rao, Jai Radhakrishnan, Wooin Ahn, Pietro A Canetta, Andrew S Bomback, Gerald B Appel, Corinne Antignac, Glen S Markowitz, Christine K Garcia, Krzysztof Kiryluk, Simone Sanna-Cherchi, Ali G Gharavi
Background: The utility of whole-exome sequencing (WES) for the diagnosis and management of adult-onset constitutional disorders has not been adequately studied. Genetic diagnostics may be advantageous in adults with chronic kidney disease (CKD), in whom the cause of kidney failure often remains unknown. Objective: To study the diagnostic utility of WES in a selected referral population of adults with CKD. Design: Observational cohort. Setting: A major academic medical center...
December 5, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29185045/preoperative-chronic-kidney-disease-is-predictive-of-oncological-outcome-of-radical-cystectomy-for-bladder-cancer
#4
Akihiko Matsumoto, Tohru Nakagawa, Atsushi Kanatani, Masaomi Ikeda, Taketo Kawai, Jimpei Miyakawa, Satoru Taguchi, Akihiro Naito, Masafumi Otsuka, Yasukazu Nakanishi, Motofumi Suzuki, Fumitaka Koga, Yasushi Nagase, Yasushi Kondo, Toshikazu Okaneya, Yoshinori Tanaka, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
PURPOSE: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncological outcomes after radical cystectomy (RC) for bladder cancer. METHODS: We reviewed the medical records of patients with urothelial bladder carcinoma who underwent RC with curative intent at seven hospitals between 1990 and 2013. After excluding patients with a history of upper urinary tract urothelial cancer or neoadjuvant chemotherapy, we analyzed 594 cases for the study. Preoperative estimated glomerular filtration rate (eGFR) was calculated using the three-variable Japanese equation for GFR estimation from serum creatinine level and age...
November 28, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29155498/global-impact-of-nephropathies
#5
REVIEW
Philip Kam-Tao Li, Terry King-Wing Ma
The global burden of chronic kidney disease (CKD) has increased substantially in recent years, partly attributed to the global epidemic of diabetes mellitus. In many countries including China, glomerulonephritis was the most common cause of end stage renal disease (ESRD). The mortality rate of dialysis patients can be as high as patients with colon, breast and prostate cancers. CKD has important socio-economic impact on the healthcare system and society. Increasing awareness and early detection of CKD cannot be overemphasized...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29137333/preoperative-chronic-kidney-disease-predicts-poor-oncological-outcomes-after-radical-nephroureterectomy-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#6
Hirotake Kodama, Shingo Hatakeyama, Naoki Fujita, Hiromichi Iwamura, Go Anan, Ken Fukushi, Takuma Narita, Toshikazu Tanaka, Yuka Kubota, Hirotaka Horiguchi, Masaki Momota, Koichi Kido, Teppei Matsumoto, Osamu Soma, Itsuto Hamano, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Atsushi Sasaki, Toshiaki Kawaguchi, Makoto Sato, Chikara Ohyama
Objective: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncological outcomes in patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy. Methods: A total of 426 patients who underwent radical nephroureterectomy at five medical centers between February 1995 and February 2017 were retrospectively examined. Oncological outcomes, including intravesical recurrence-free, visceral recurrence-free, cancer-specific, and overall survival rates (intravesical RFS, visceral RFS, CSS, and OS, respectively) stratified by preoperative CKD status (CKD vs...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103151/monitoring-the-estimated-glomerular-filtration-rate-egfr-in-patients-with-small-cell-lung-cancer-during-chemotherapy-equations-based-on-serum-creatinine-or-cystatin-c
#7
Xue Tian, Xinxing Zhang, Min Yu, You Lu, Zhenyu Ding, Meijuan Huang, Feng Peng, Li Ren, Jin Wang, Yongsheng Wang, Yong Xu, Jiang Zhu, Lin Zhou, Xiaojuan Zhou, Min Deng, Xin Tang, Youling Gong
BACKGROUND: This study compared the differences between the estimated glomerular filtration rate (eGFR) calculated by several equations based on serum creatinine (Scr) and cystatin C (CysC) concentrations for monitoring renal function in patients with small-cell lung cancer (SCLC) during chemotherapy. METHODS: Seventy-one patients with SCLC were retrospectively analyzed. The eGFR before and after each chemotherapy cycle was calculated by the following equations: the chronic kidney disease epidemiology collaboration (CKD-EPI) equation, the modification of diet in renal disease (MDRD) equation, the Cockcroft-Gault (CG) equation, and five CysC-based equations...
November 4, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29063706/relationship-between-mortality-and-cancer-bearing-status-in-patients-with-chronic-kidney-disease-who-attended-an-educational-program
#8
Akihito Tanaka, Daijo Inaguma, Yu Watanabe, Minako Murata, Hibiki Shinjo, Kiyomi Koike, Yasuhiro Otsuka, Asami Takeda
Patients with malignancy have a poorer prognosis than others do, which must be taken into consideration when treating them for chronic kidney disease (CKD). However, there are few studies investigating their prognosis. This was an observational study of 515 (394 men and 121 women) stable non-dialysis patients with CKD who attended a CKD educational program. Mean age was 68.8 ± 13.0 years. Median follow-up was 968.5 days. Mean creatinine was 3.4 ± 1.6 mg/dL. Of these, 63 had malignancy and 452 did not; 20...
October 24, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29029534/is-preoperative-chronic-kidney-disease-status-associated-with-oncologic-outcomes-in-upper-urinary-tract-urothelial-carcinoma-a-multicenter-propensity-score-matched-analysis
#9
Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung-Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon
PURPOSE: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). RESULTS: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancer-specific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29018140/incident-ckd-after-radical-or-partial-nephrectomy
#10
John T Leppert, Remy W Lamberts, I-Chun Thomas, Benjamin I Chung, Geoffrey A Sonn, Eila C Skinner, Todd H Wagner, Glenn M Chertow, James D Brooks
The comparative effectiveness of partial nephrectomy versus radical nephrectomy to preserve kidney function has not been well established. We determined the risk of clinically significant (stage 4 and higher) CKD after radical or partial nephrectomy among veterans treated for kidney cancer in the Veterans Health Administration (2001-2013). Among patients with preoperative eGFR≥30 ml/min per 1.73 m(2), the incidence of CKD stage 4 or higher after radical (n=9759) or partial nephrectomy (n=4370) was 7.9% overall...
October 10, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28977873/preoperative-chronic-kidney-disease-predicts-poor-oncological-outcomes-after-radical-cystectomy-in-patients-with-muscle-invasive-bladder-cancer
#11
Itsuto Hamano, Shingo Hatakeyama, Hiromichi Iwamurau, Naoki Fujita, Ken Fukushi, Takuma Narita, Kazuhisa Hagiwara, Ayumu Kusaka, Shogo Hosogoe, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Chikara Ohyama
OBJECTIVE: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncologic outcomes in muscle-invasive bladder cancer patients who underwent radical cystectomy. METHODS: A total of 581 patients who underwent radical cystectomy at four medical centers between January 1995 and February 2017 were examined retrospectively. We investigated oncologic outcomes, including progression-free, cancer-specific, and overall survival (PFS, CSS, and OS, respectively) stratified by preoperative CKD status (pre-CKD vs...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28963281/irradiation-enhanced-risks-of-hospitalised-pneumonopathy-in-lung-cancer-patients-a-population-based-surgical-cohort-study
#12
Shih-Kai Hung, Yi-Chun Chen, Wen-Yen Chiou, Chun-Liang Lai, Moon-Sing Lee, Yuan-Chen Lo, Liang-Cheng Chen, Li-Wen Huang, Nai-Chuan Chien, Szu-Chi Li, Dai-Wei Liu, Feng-Chun Hsu, Shiang-Jiun Tsai, Michael Wy Chan, Hon-Yi Lin
OBJECTIVE: Pulmonary radiotherapy has been reported to increase a risk of pneumonopathy, including pneumonitis and secondary pneumonia, however evidence from population-based studies is lacking. The present study intended to explore whether postoperative irradiation increases occurrence of severe pneumonopathy in lung cancer patients. DESIGN, SETTING AND PARTICIPANTS: The nationwide population-based study analysed the Taiwan National Health Insurance Research Database (covered >99% of Taiwanese) in a real-world setting...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28948387/possible-risk-of-overestimation-of-renal-function-using-cystatin-c-based-egfr-in-testicular-cancer-survivors-treated-with-cisplatin-based-chemotherapy
#13
Daishi Ichioka, Koji Kawai, Ken Tanaka, Ryutaro Ishitsuka, Takayuki Yoshino, Tomokazu Kimura, Shuya Kandori, Takashi Kawahara, Takahiro Kojima, Joichi Usui, Kunihiro Yamagata, Jun Miyazaki, Hiroyuki Nishiyama
BACKGROUND: Chronic kidney disease (CKD) is a major long-term morbidity of testicular cancer (TC) survivors cured by cisplatin-based chemotherapy. We conducted the present study to elucidate the usefulness of cystatin-based estimated glomerular filtration rates (eGFRcys) for diagnosis of CKD compared to creatinine-based eGFR (eGFRcreat) in those patients. METHODS: eGFRcys and eGFRcreat were measured in 53 TC survivors. The 24-h creatinine clearance (CrCl) was measured in 12 TC survivors and 17 CKD patients with medical disease; all of them had eGFRcreat <60 m/min/1...
September 25, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28902231/risk-factors-for-the-progression-of-chronic-kidney-disease-after-acute-kidney-injury
#14
Benedito Jorge Pereira, Silvana Barreto, Thais Gentil, Larissa S Assis, Emília Md Soeiro, Isac de Castro, Sandra M Laranja
INTRODUCTION: The incidence of chronic kidney disease (CKD) is increasing with the increasing age of the population and the increasing number of elderly survivors of acute kidney injury (AKI). The risk factors for the progression of CKD after AKI are unclear. OBJECTIVE: To investigate the association between AKI and its progression to CKD and the risk factors involved. METHODS: An observational, retrospective study of AKI patients followed from 2009 to 2012 was carried out...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28885736/prevalence-and-prognostic-impact-of-anemia-and-iron-deficiency-in-patients-hospitalized-in-an-internal-medicine-ward-the-pro-iron-study
#15
Cândida Fonseca, Manuel Araújo, Patrícia Moniz, Filipa Marques, Inês Araújo, Luís Costa, Joana Rodrigues, Luciana Frade, Arturo Botella, Susana Jesus, Ana Leitão, Luís Campos
OBJECTIVES: To assess prevalence, predictive factors, and prognostic impact on in-hospital mortality of anemia, iron deficiency anemia (IDA), iron deficiency with or without anemia (ID), and iron deficiency without anemia (IDWA) in patients admitted to an internal medicine ward. METHODS: This 1-year prospective study collected data on demographics, medical history, and blood tests in 771 consecutive patients on admission. RESULTS: Most patients were ≥65 years old (80%) and had hypertension (63%), moderate chronic kidney disease (CKD) (43%), and heart failure (41%)...
September 8, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28859893/predictors-of-long-term-survival-after-renal-cancer-surgery
#16
Joseph Zabell, Sevag Demirjian, Brian R Lane, Ithaar H Derweesh, Sudhir Isharwal, Chalairat Suk-Ouichai, Jitao Wu, Diego Aguilar Palacios, Steven C Campbell
PURPOSE: Renal cancer surgery can adversely impact long-term function and survival. We evaluated predictors of chronic kidney disease 5 years and nonrenal cancer mortality 10 years after renal cancer surgery. MATERIALS AND METHODS: We analyzed the records of 4,283 patients who underwent renal cancer surgery from 1997 to 2008. Radical and partial nephrectomy were performed in 46% and 54% of patients, respectively. Cumulative probability ordinal modeling was used to predict chronic kidney disease status 5 years after surgery and multivariable logistic regression was used to predict nonrenal cancer mortality at 10 years...
August 30, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28842165/chronic-kidney-disease-basal-insulin-glargine-and-health-outcomes-in-people-with-dysglycemia-the-origin-study
#17
Vasilios Papademetriou, Eric S Nylen, Michael Doumas, Jeff Probstfield, Johannes F E Mann, Richard E Gilbert, Hertzel C Gerstein
BACKGROUND: Early stages of chronic kidney disease are associated with an increased cardiovascular risk in patients with established type 2 diabetes and macrovascular disease. The role of early stages of chronic kidney disease on macrovascular outcomes in prediabetes and early type 2 diabetes mellitus is not known. In the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial, the introduction of insulin had no effect on cardiovascular outcomes compared with standard therapy...
August 31, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28834125/analysis-of-survival-for-patients-with-chronic-kidney-disease-primarily-related-to-renal-cancer-surgery
#18
Jitao Wu, Chalairat Suk-Ouichai, Wen Dong, Elvis Caraballo Antonio, Ithaar H Derweesh, Brian R Lane, Sevag Demirjian, Jianbo Li, Steven C Campbell
OBJECTIVES: To evaluate predictors of long-term survival for patients with chronic kidney disease primarily due to surgery (CKD-S). Patients with CKD-S have generally good survival that approximates patients who do not have CKD even after renal cancer surgery (RCS), yet there may be heterogeneity within this cohort. PATIENTS AND METHODS: From 1997 to 2008, 4 246 patients underwent RCS at our centre. The median (interquartile range [IQR]) follow-up was 9.4 (7.3-11...
August 21, 2017: BJU International
https://www.readbyqxmd.com/read/28798802/prescribed-renoprotective-chinese-herbal-medicines-were-associated-with-a-lower-risk-of-all-cause-and-disease-specific-mortality-among-patients-with-chronic-kidney-disease-a-population-based-follow-up-study-in-taiwan
#19
Chuan-Fa Hsieh, Huan-Cheng Chang, Song-Lih Huang, Chien-Lung Chen, Wei-Ta Chen, Chen-Chang Yang
Chinese herbal medicines (CHMs) containing aristolochic acid (AA) are associated with chronic kidney disease (CKD), but some prescribed CHMs have been shown to possess renoprotective effects. We conducted a nationwide retrospective cohort study to delineate the role of prescribed CHMs on the CKD progression. Renoprotective CHM (RPCHM) was defined if a CHM contained dong chong xia cao (Cordyceps sinensis (Berk.) Sacc.), da huang (Rheum palmatum L), huang qi (Astragalus membranaceus), dan shen (Salvia miltiorrhiza Bge...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28795762/risk-of-non-melanoma-skin-cancer-in-patients-with-chronic-kidney-disease-and-its-relationship-to-uraemic-pruritus
#20
Chia-Chen Wang, Chao-Hsiun Tang, Siao-Yuan Huang, Kuan-Chih Huang, Yuh-Mou Sue
This study investigated the risk of non-melanoma skin cancer (NMSC) in pre-dialysis patients with chronic kidney disease (CKD) and explored associated risk factors. A population-based cohort of 1,515,858 Taiwanese CKD patients was included. The standardized incidence ratio (SIR) for incident NMSC was determined. Compared with the general population, a 1.14-fold risk of NMSC was found in the CKD cohort. NMSC risk was significant in patients with pre-dialysis stage 5 CKD and anaemia (1.48-fold), and in those with uraemic pruritus after long-term antihistamine treatment (1...
August 10, 2017: Acta Dermato-venereologica
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