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Family Work for Psychosis

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https://www.readbyqxmd.com/read/28098631/after-the-fall-the-tapestry-of-disturbance-and-recovery
#1
Nalini M Nadkarni
On July 3, 2015, Nalini Nadkarni, a world-renowned ecologist who had been studying the biologic processes of ecosystem disturbance and recovery, sustained a catastrophic 50-foot free-fall from the top of the rainforest canopy to the forest floor at her remote field research site. She lost consciousness in shock and sustained life-threatening injuries. Her accompanying students hiked out, radio-called 911, and the Harborview Medical Center (Seattle) Medivac team arrived 4 hours later to rescue her. Her prognosis was extremely grim; her family gathered in anticipation of her death as she underwent four operations during her 10 days in the ICU...
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28095883/moderated-online-social-therapy-for-carers-of-young-people-recovering-from-first-episode-psychosis-study-protocol-for-a-randomised-controlled-trial
#2
John Gleeson, Reeva Lederman, Helen Herrman, Peter Koval, Dina Eleftheriadis, Sarah Bendall, Sue M Cotton, Mario Alvarez-Jimenez
BACKGROUND: First-episode psychosis most often has its onset during late adolescence. In caring for the young person, families endure high levels of stress and depression. Meanwhile, the social networks of families often erode. Our group has previously shown that family cognitive behaviour therapy (CBT) leads to significantly improved perceived stress compared with specialist first-episode treatment as usual; however, there are well-known barriers to the dissemination of effective family interventions...
January 17, 2017: Trials
https://www.readbyqxmd.com/read/28072643/early-life-trauma-in-hospitalized-patients-with-mood-disorders-and-its-association-with-clinical-outcomes
#3
Ajay K Parsaik, Noha Abdelgawad, Jigar K Chotalia, Scott D Lane, Teresa A Pigott
BACKGROUND: The prevalence of childhood trauma and its impact on clinical outcomes in hospitalized patients with mood disorders is unknown. We studied the frequency of childhood trauma among inpatient adults with mood disorders and its association with clinical outcomes. METHODS: Patients admitted to our hospital with a primary diagnosis of mood disorders completed the short form of the Early Trauma Inventory-Self-Report (ETISR-SF), the Sheehan Disability Scale, and the Clinician-Rated Dimensions of Psychosis Symptom Severity scale...
January 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/27968842/quality-of-life-and-health-utility-scores-for-common-cancers-in-china-a-multicentre-cross-sectional-survey
#4
Ju-Fang Shi, Hui-Yao Huang, Lan-Wei Guo, Dian Shi, Xiu-Ying Gu, Han Liang, Le Wang, Jian-Song Ren, Ya-Na Bai, A-Yan Mao, Guo-Xiang Liu, Xian-Zhen Liao, Kai Zhang, Jie He, Min Dai
BACKGROUND: The measurement of quality-adjusted life-years (QALYs) forms a key component of cost-utility evaluation in cancer intervention; however, detailed data for utility weights by cancer type and health status are still scarce both in China and other regions. The aim of this study was to systematically evaluate utility scores in relation to the most common six cancers in China in 2012 (lung, breast, colorectal, oesophageal, liver, and stomach cancer). METHODS: As a part of a Screening Program in Urban China (CanSPUC) supported by the central government of China, we undertook a cross-sectional survey in 13 provinces across China from 2013 to 2014...
October 2016: Lancet
https://www.readbyqxmd.com/read/27965857/culturally-adapted-family-intervention-cafi-for-african-caribbeans-diagnosed-with-schizophrenia-and-their-families-a-feasibility-study-protocol-of-implementation-and-acceptability
#5
Dawn Edge, Amy Degnan, Sarah Cotterill, Katherine Berry, Richard Drake, John Baker, Christine Barrowclough, Adwoa Hughes-Morley, Paul Grey, Dinesh Bhugra, Patrick Cahoon, Nicholas Tarrier, Shôn Lewis, Kathryn Abel
BACKGROUND: African-Caribbeans in the UK have the highest schizophrenia incidence and greatest inequity in access to mental health services of all ethnic groups. The National Institute for Health and Care Excellence (NICE) highlights this crisis in care and urgent need to improve evidence-based mental healthcare, experiences of services and outcomes for this group. Family intervention (FI) is clinically and cost-effective for the management of schizophrenia but it is rarely offered. Evidence for FI with minority ethnic groups generally, and African-Caribbeans in particular, is lacking...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27903327/auditory-vigilance-and-working-memory-in-youth-at-familial-risk-for-schizophrenia-or-affective-psychosis-in-the-harvard-adolescent-family-high-risk-study
#6
Larry J Seidman, Andrea Pousada-Casal, Silvia Scala, Eric C Meyer, William S Stone, Heidi W Thermenos, Elena Molokotos, Jessica Agnew-Blais, Ming T Tsuang, Stephen V Faraone
BACKGROUND: The degree of overlap between schizophrenia (SCZ) and affective psychosis (AFF) has been a recurring question since Kraepelin's subdivision of the major psychoses. Studying nonpsychotic relatives allows a comparison of disorder-associated phenotypes, without potential confounds that can obscure distinctive features of the disorder. Because attention and working memory have been proposed as potential endophenotypes for SCZ and AFF, we compared these cognitive features in individuals at familial high-risk (FHR) for the disorders...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27872267/endophenotypes-epigenetics-polygenicity-and-more-irv-gottesman-s-dynamic-legacy
#7
David L Braff, Carol A Tamminga
First, we describe the hallmark contributions of Irv Gottesman's pioneering scholarship for schizophrenia research including concepts of polygenicity, gene × environment interactions, epigenetics and the endophenotype concept. Gottesman and colleagues' twin studies showed that genes, not social factors, mediate schizophrenia risk. He then showed that schizophrenia is highly polygenic. Next, he introduced the concept of epigenetics into schizophrenia research. Gottesman then introduced the quantitative endophenotype concept...
January 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27623121/-advocacy-for-the-establishment-of-a-comprehensive-strategy-to-reduce-the-burden-of-schizophrenic-disorders
#8
D Leguay
This article attempts to identify and put into perspective the different approaches that could globally prevent the suffering induced by schizophrenia, from the detection of early psychosis to the impact on individual and family functioning and emotional health. Schizophrenia causes, at the community level, a number of difficult consequences and associated costs, which likely could be reduced if specific strategies, already known and documented internationally, were applied. Two areas not explored in this article: the role of medication and the issue of suicide prevention...
October 2016: L'Encéphale
https://www.readbyqxmd.com/read/27619055/search-for-protective-factors-for-psychosis-a-population-based-sample-with-special-interest-in-unaffected-individuals-with-parental-psychosis
#9
Emmi Keskinen, Riikka Marttila, Heli Koivumaa-Honkanen, Kristiina Moilanen, Sirkka Keinänen-Kiukaanniemi, Markku Timonen, Matti Isohanni, John McGrath, Jouko Miettunen, Erika Jääskeläinen
AIM: To find factors that are associated with not having psychotic illness in a prospective general population sample, with a special interest in individuals with parental psychosis. METHODS: Data from the Northern Finland Birth Cohort 1966 (n = 10 458) and several registers were used to detect individuals with and without parental psychosis. Altogether, 594 persons had parent(s) with psychosis and 48 of them also had psychosis subsequently. Variables related to pregnancy and birth, family and childhood, health and habits in adolescence, school performance and physical activity were studied to identify determinants of unaffected status among individuals with and without parental psychosis...
September 13, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27541345/incidence-of-stressful-life-events-and-influence-of-sociodemographic-and-clinical-variables-on-the-onset-of-first-episode-psychosis
#10
Anna Butjosa, Juana Gómez-Benito, Elena Huerta-Ramos, Núria Del Cacho, Ana Barajas, Iris Baños, Judith Usall, Montserrat Dolz, Bernardo Sánchez, Janina Carlson, Josep Maria Haro, Susana Ochoa
This study presents a quantitative analysis of the incidence of stressful life events (SLEs) and the variables gender, age at onset, family history and psychotic symptoms in patients with first-episode psychosis (FEP). A descriptive, cross-sectional methodology was used to interview 68 patients with FEP between 13 and 47 years of age. The Psychiatric Epidemiology Research Interview Life Events Scale collected one-year period prior to onset of FEP - used to analyse the subcategories academic, work, love and marriage, children, residence, legal affairs, finances and social activities-, Positive and Negative Syndrome Scale, and Clinical Global Impression-Schizophrenia scale were used to assess the relevance of certain SLEs during adolescence...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27533096/men-s-experiences-of-having-a-partner-who-requires-mother-and-baby-unit-admission-for-first-episode-postpartum-psychosis
#11
Rebecca Boddy, Carolyn Gordon, Fiona MacCallum, Mary McGuinness
AIMS: The aim of this study was to explore the experiences of men during their partner's admission to a Mother and Baby Unit for first episode postpartum psychosis. BACKGROUND: Postpartum psychosis can be life-changing for women, however little is known about the impact on their partners or their partners' needs. DESIGN: An Interpretative Phenomenological Analysis approach was used to analyse interview transcripts. METHODS: Semi-structured interviews were conducted with seven participants...
August 17, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27211562/phenotypically-distinct-subtypes-of-psychosis-accompany-novel-or-rare-variants-in-four-different-signaling-genes
#12
Thorsten M Kranz, Adam Berns, Jerry Shields, Karen Rothman, Julie Walsh-Messinger, Raymond R Goetz, Moses V Chao, Dolores Malaspina
BACKGROUND: Rare gene variants are important sources of schizophrenia vulnerability that likely interact with polygenic susceptibility loci. This study examined if novel or rare missense coding variants in any of four different signaling genes in sporadic schizophrenia cases were associated with clinical phenotypes in an exceptionally well-characterized sample. METHOD: Structured interviews, cognition, symptoms and life course features were assessed in 48 ethnically-diverse cases with psychosis who underwent targeted exome sequencing of PTPRG (Protein Tyrosine Phosphatase, Receptor Type G), SLC39A13 (Solute Carrier Family 39 (Zinc Transporter) Member 13), TGM5 (transglutaminase 5) and ARMS/KIDINS220 (Ankyrin repeat-rich membrane spanning protein or Kinase D-Interacting Substrate of 220kDa)...
April 2016: EBioMedicine
https://www.readbyqxmd.com/read/27086758/psychiatric-disorders-among-prisoners-a-national-study-in-egypt
#13
A El-Gilany, M Khater, Z Gomaa, E Hussein, I Hamdy
OBJECTIVES: To estimate the overall prevalence of psychiatric disorders among prisoners and its associated factors, and to estimate the prevalence of different mental and personality disorders. METHODS: This was a cross-sectional descriptive study carried out in 16 randomly selected prisons in Egypt. A stratified proportional random sample of 1350 adult prisoners was included in the study. Data were collected by a psychiatrist by direct interview with prisoners...
March 2016: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/27069287/an-interpersonal-cbt-framework-for-involving-relatives-in-interventions-for-psychosis-evidence-base-and-clinical-implications
#14
Fiona Lobban, Christine Barrowclough
Working with families in psychosis improves outcomes and is cost effective. However, implementation is poor, partly due to lack of a clear theoretical framework. This paper presents an interpersonal framework for extending the more familiar cognitive behavioral therapy model of psychosis to include the role of relatives' behavior in the process of recovery. A summary of the framework is presented, and the evidence to support each link is reviewed in detail. Limitations of the framework are discussed and further research opportunities highlighted...
2016: Cognitive Therapy and Research
https://www.readbyqxmd.com/read/26977129/infanticide-by-a-mother-with-untreated-schizophrenia
#15
Rahul Saha, Shubh Mohan Singh, Anil Nischal
This case report describes a 30-year-old mother of four with a 6-year history of obvious paranoia and psychosis from a poor rural farming community in India. Her symptoms and social functioning deteriorated over time, but the family did not seek medical care until she killed her 3-month-old daughter while under the influence of command hallucinations. Subsequent treatment with antipsychotic medication resulted in control of her psychotic symptoms and greatly improved psychosocial functioning. This case is an example of one of the many negative consequences of a community's failure to recognize and treat mental illnesses...
October 2015: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/26520449/biological-and-psychosocial-risk-factors-for-psychotic-major-depression
#16
M Heslin, R Desai, J M Lappin, K Donoghue, B Lomas, U Reininghaus, A Onyejiaka, T Croudace, P B Jones, R M Murray, P Fearon, G A Doody, P Dazzan, H L Fisher, A Demjaha, T Craig, C Morgan
AIMS: Few studies have investigated risk factors for psychotic major depression (PMD). We aimed to investigate the biological and psychosocial risk factors associated with PMD compared with other psychotic disorders. METHODS: Based on the aetiology and ethnicity in schizophrenia and other psychoses (ÆSOP) study, we used a case-control study to identify and recruit, at baseline and 10-year follow-up, all first episode cases of psychosis, presenting for the first time to specialist mental health services in defined catchment areas in the UK...
February 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/26467751/sexual-dimorphic-abnormalities-in-white-matter-geometry-common-to-schizophrenia-and-non-psychotic-high-risk-subjects-evidence-for-a-neurodevelopmental-risk-marker
#17
Peter Savadjiev, Larry J Seidman, Heidi Thermenos, Matcheri Keshavan, Susan Whitfield-Gabrieli, Tim J Crow, Marek Kubicki
The characterization of neurodevelopmental aspects of brain alterations require neuroimaging methods that reflect correlates of neurodevelopment, while being robust to other progressive pathological processes. Newly developed neuroimaging methods for measuring geometrical features of the white matter fall exactly into this category. Our recent work shows that such features, measured in the anterior corpus callosum in diffusion MRI data, correlate with psychosis symptoms in patients with adolescent onset schizophrenia and subside a reversal of normal sexual dimorphism...
January 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/26190643/pituitary-gland-volume-and-psychosocial-stress-among-children-at-elevated-risk-for-schizophrenia
#18
A E Cullen, F L Day, R E Roberts, C M Pariante, K R Laurens
BACKGROUND: Pituitary volume enlargements have been observed among individuals with first-episode psychosis. These abnormalities are suggestive of hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, which may contribute to the development of psychosis. However, the extent to which these abnormalities characterize individuals at elevated risk for schizophrenia prior to illness onset is currently unclear, as volume increases, decreases and no volume differences have all been reported relative to controls...
November 2015: Psychological Medicine
https://www.readbyqxmd.com/read/26165958/screening-schizotypal-personality-disorder-for-detection-of-clinical-high-risk-of-psychosis-in-chinese-mental-health-services
#19
TianHong Zhang, HuiJun Li, YingYing Tang, Hui Li, LiNa Zheng, Qian Guo, ShanShan Zhao, KaiMing Zhuo, ZhenYing Qian, LanLan Wang, YunFei Dai, Annabelle Chow, ChunBo Li, KaiDa Jiang, JiJun Wang, ZePing Xiao
Schizotypal personality disorder (SPD) is viewed as a marker of prodromal psychosis. However, information regarding genetic risk (e.g. SPD) is often overlooked in the identification process. This study assessed whether SPD screening questionnaire help the prodromal psychosis (also widely applied "clinical high risk" (CHR) for clinical sample) detection in Chinese mental health service. This work also examined whether SPD had higher frequency in genetic risk population and CHR subjects. Two wave studies concerning the SPD identification was used for analysis...
August 30, 2015: Psychiatry Research
https://www.readbyqxmd.com/read/26134829/challenges-for-group-leaders-working-with-families-dealing-with-early-psychosis-a-qualitative-study
#20
Liv Nilsen, Irene Norheim, Jan C Frich, Svein Friis, Jan Ivar Røssberg
BACKGROUND: Family work is one of the best researched psychosocial interventions for patients with chronic psychosis. However, family work is less studied for patients with a first episode psychosis and the studies have revealed contradicting results. To our knowledge, no previous studies have examined qualitatively group leaders' experiences with family work. In the present study we wanted to explore challenges faced by mental health professionals working as group leaders for family interventions with first episode psychosis patients...
2015: BMC Psychiatry
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