Vaidhvi Singh, Gail West, Claudio Fiocchi, Caryn E Good, Jeffry Katz, Michael R Jacobs, Armand Earl Ko Dichosa, Chris Flask, Mathew Wesolowski, Cassidy McColl, Brandon Grubb, Sadia Ahmed, Nicholas C Bank, Kavitha Thamma, Ilya Bederman, Bernadette Erokwu, Xinlin Yang, Mark S Sundrud, Paola Menghini, Abigail Raffner Basson, Jessica Ezeji, Satish E Viswanath, Alida Veloo, David B Sykes, Fabio Cominelli, Alex Rodriguez-Palacios
Crohn's disease (CD) has been traditionally viewed as a chronic inflammatory disease that cause gut wall thickening and complications, including fistulas, by mechanisms not understood. By focusing on Parabacteroides distasonis (presumed modern succinate-producing commensal probiotic), recovered from intestinal microfistulous tracts (cavernous fistulous micropathologies CavFT proposed as intermediate between 'mucosal fissures' and 'fistulas') in two patients that required surgery to remove CD-damaged ilea, we demonstrate that such isolates exert pathogenic/pathobiont roles in mouse models of CD...
January 10, 2024: bioRxiv