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Irina Mindlis, Esperanza Morales-Raveendran, Emily Goodman, Kevin Xu, Clara Vila-Castelar, Kristine Keller, Ginger Crawford, Shynah James, Craig Katz, Laura E Crowley, Rafael E de la Hoz, Steven Markowitz, Juan P Wisnivesky
Objective Using data from a cohort of World Trade Center (WTC) rescue and recovery workers with asthma, we assessed whether meeting criteria for post-traumatic stress disorder (PTSD), sub- PTSD and for specific PTSD symptom dimensions are associated with increased asthma morbidity. Methods Participants underwent a Structured Clinical Interview for Diagnostic and Statistical Manual to assess presence of PTSD following DSM-IV criteria during in-person interviews between December 2013 and April 2015. We defined sub-threshold PTSD as meeting criteria for two of three symptom dimensions: re-experiencing, avoidance, or hyper-arousal...
December 1, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Dana Hashim, Paolo Boffetta, Matthew Galsky, William Oh, Roberto Lucchini, Michael Crane, Benjamin Luft, Jaqueline Moline, Iris Udasin, Denise Harrison, Emanuela Taioli
An increased incidence of prostate cancer was reported in three cohorts of World Trade Center (WTC) respondents. It is uncertain whether this increase is because of WTC-related exposures or enhanced surveillance. Prostate cancer cases (2002-2013) were obtained from the WTC Health Program. Age, race, and Gleason score distribution were compared with New York State Cancer Registry cases from the same time period. Multivariate models were adjusted for age and race. Analyses of clinical characteristics of prostate cancer cases within the cohort were also carried out, adjusting for age, race, and WTC exposure categories...
November 24, 2016: European Journal of Cancer Prevention
Kai Wu, Lingzhi Li, Chitra Thakur, Yongju Lu, Xiangmin Zhang, Zhengping Yi, Fei Chen
Several epidemiological studies suggested an increased incidence rate of multiple myeloma (MM) among first responders and other individuals who exposed to World Trade Center (WTC) dust. In this report, we provided evidence showing that WTC dust is potent in inducing mdig protein and/or mRNA in bronchial epithelial cells, B cells and MM cell lines. An increased mdig expression in MM bone marrow was observed, which is associated with the disease progression and prognosis of the MM patients. Through integrative genomics and proteomics approaches, we further demonstrated that mdig directly interacts with c-myc and JAK1 in MM cell lines, which contributes to hyperactivation of the IL-6-JAK-STAT3 signaling important for the pathogenesis of MM...
November 11, 2016: Scientific Reports
Mark M Stecker, Huiying Yu, Renee Barlev, Michael Marmor, Marc Wilkenfeld
OBJECTIVE: The aim of this study was to describe the clinical phenotype of a limited group of responders and survivors of the World Trade Center (WTC) disaster who were referred for the evaluation of neuropathic symptoms. METHODS: Sixteen patients with WTC exposure were referred to a neurologist for evaluation. All had a neurologic examination. Most had electromyogram and nerve conduction testing/nerve conduction studies as well as appropriate imaging and blood tests...
November 2016: Journal of Occupational and Environmental Medicine
Zewei Wang, Qing Yang, Li Min Chen
The goals of this study are to characterize the temporal dynamics of inter-regional connectivity of the brain in chronic headache (CH) patients versus their age/gender matched controls (CONCH, n=28 pairs), and to determine whether dynamic measures reveal additional features to static functional connectivity and correlate with psychometric scores. Cortical thickness and inter-regional resting state fMRI connectivity were quantified and compared between CH and CONCH groups. Six cortical regions of interest (ROI) pairs that exhibited correlated cortical thickness and static functional connectivity abnormalities were selected for temporal dynamic analysis...
October 14, 2016: Magnetic Resonance Imaging
Brian T Pavilonis, Franklin E Mirer
The cleanup effort following the destruction of the World Trade Center (WTC) was unprecedented and involved removal of 1.8 million tons of rubble over a nine month period. Work at the site occurred 24 hours a day, seven days a week and involved thousands of workers during the process. The Occupational Safety and Health Administration (OSHA) conducted personal and area exposure sampling during the cleanup of the site. Secondary data analysis was performed on OSHA air sampling data for respirable dust and silica from September 2001 to June 2002 at the WTC recovery site to characterize workers' exposure...
October 7, 2016: Journal of Occupational and Environmental Hygiene
Sean A P Clouston, Roman Kotov, Robert H Pietrzak, Benjamin J Luft, Adam Gonzalez, Marcus Richards, Camilo J Ruggero, Avron Spiro, Evelyn J Bromet
INTRODUCTION: During the World Trade Center (WTC) attacks, responders who helped in search, rescue, and recovery endured multiple traumatic and toxic exposures. One-fifth subsequently developed post-traumatic stress disorder (PTSD). PTSD has been linked to dementia in veterans. This study examined the association between WTC-related PTSD and cognitive impairment (CI) in WTC responders. METHODS: A one-third sample of responders (N = 818) reporting for annual monitoring visits were screened for cognitive impairment and dementia using the Montreal Cognitive Assessment from January 2014-April 2015...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Sarah R Horn, Robert H Pietrzak, Clyde Schechter, Evelyn J Bromet, Craig L Katz, Dori B Reissman, Roman Kotov, Michael Crane, Denise J Harrison, Robin Herbert, Benjamin J Luft, Jacqueline M Moline, Jeanne M Stellman, Iris G Udasin, Philip J Landrigan, Michael J Zvolensky, Steven M Southwick, Adriana Feder
Posttraumatic stress disorder (PTSD) is a debilitating and often chronic psychiatric disorder. Following the 9/11/2001 World Trade Center (WTC) attacks, thousands of individuals were involved in rescue, recovery and clean-up efforts. While a growing body of literature has documented the prevalence and correlates of PTSD in WTC responders, no study has evaluated predominant typologies of PTSD in this population. Participants were 4352 WTC responders with probable WTC-related DSM-IV PTSD. Latent class analyses were conducted to identify predominant typologies of PTSD symptoms and associated correlates...
September 2, 2016: Journal of Psychiatric Research
Masashi Tsukamoto, Kenichiro Kohara, Koji Takeuchi
The within-trial contrast hypothesis (WTC) provides a more parsimonious explanation for the phenomenon that humans and animals prefer outcomes that follow more effortful events to outcomes that follow less effortful events (Zentall, 2013). We conducted two WTC experiments with human adults. In Experiment 1, we manipulated the difficulty of a preceding event by varying the interresponse time and the limited-hold interval during differential reinforcement with a low response rate schedule, to examine the effect of effort on the preference for the subsequent stimuli...
September 12, 2016: Learning & Behavior
Tomohide Kubo, Masaya Takahashi, Xinxin Liu, Hiroki Ikeda, Fumiharu Togo, Akihito Shimazu, Katsutoshi Tanaka, Naoki Kamata, Yoshiko Kubo, Junko Uesugi
OBJECTIVES: This observational study aimed to determine how 1-year changes in work time control (WTC) have an impact upon objectively measured fatigue and sleep among employees. METHODS: Thirty-nine employees were divided into two groups according to whether or not their WTC increased from baseline to 1 year later. Psychomotor vigilance task (PVT) and wrist actigraphy were used to objectively measure fatigue and sleep, respectively. Self-reported outcomes were also measured...
September 6, 2016: Journal of Occupational and Environmental Medicine
Jiehui Li, Robert M Brackbill, Hannah T Jordan, James E Cone, Mark R Farfel, Steven D Stellman
BACKGROUND: Little is known about the direction of causality among asthma, posttraumatic stress disorder (PTSD), and onset of gastroesophageal reflux symptoms (GERS) after exposure to the 9/11/2001 World Trade Center (WTC) disaster. METHODS: Using data from the WTC Health Registry, we investigated the effects of early diagnosed post-9/11 asthma and PTSD on the late onset and persistence of GERS using log-binomial regression, and examined whether PTSD mediated the asthma-GERS association using structural equation modeling...
September 2016: American Journal of Industrial Medicine
James E Cone, Sukhminder Osahan, Christine C Ekenga, Sara A Miller-Archie, Steven D Stellman, Monique Fairclough, Stephen M Friedman, Mark R Farfel
BACKGROUND: Although airborne respiratory irritants at the World Trade Center (WTC) site have been associated with asthma among WTC Ground Zero workers, little is known about asthma associated with work at the Staten Island landfill or barges. METHODS: To evaluate the risk of asthma first diagnosed among Staten Island landfill and barge workers, we conducted a survey and multivariable logistic regression analysis regarding the association between Staten Island landfill and barge-related work exposures and the onset of post-9/11 asthma...
September 2016: American Journal of Industrial Medicine
Rachel Zeig-Owens, Anna Nolan, Barbara Putman, Ankura Singh, David J Prezant, Michael D Weiden
BACKGROUND: High rates of upper and lower airways disease have occurred in Fire Department of the City of New York (FDNY) workers exposed to the World Trade Center (WTC) disaster site. Most experienced acute declines in pulmonary function, and some continued to experience decline over 14 years of follow-up. Similarly, some with rhinosinusitis had symptoms requiring sinus surgery. AIM: To increase generalizability of biomarker investigation, we describe biomarkers of risk for upper and lower airway injury that do not require stored serum...
September 2016: American Journal of Industrial Medicine
Caralee Caplan-Shaw, Angeliki Kazeros, Deepak Pradhan, Kenneth Berger, Roberta Goldring, Sibo Zhao, Mengling Liu, Yongzhao Shao, Maria Elena Fernandez-Beros, Michael Marmor, Nomi Levy-Carrick, Rebecca Rosen, Lucia Ferri, Joan Reibman
OBJECTIVE: Longitudinal assessment of lower respiratory symptoms (LRS) in community members with World Trade Center (WTC) exposures. METHODS: Adult members of a treatment program with complete standardized visits were evaluated (n = 798). Association of demographic characteristics, mental health symptoms and lung function with trajectory of LRS between initial and monitoring visit was evaluated. RESULTS: Severe LRS were present in 70% at initial and 63% at monitoring visit...
September 2016: American Journal of Industrial Medicine
Kenneth I Berger, Samantha Kalish, Yongzhao Shao, Michael Marmor, Angeliki Kazeros, Beno W Oppenheimer, Yinny Chan, Joan Reibman, Roberta M Goldring
INTRODUCTION: Small airway dysfunction occurs following WTC dust exposure, but its role in producing symptoms is unclear. METHODS: Methacholine challenge (MCT) was used to assess the relationship between onset of respiratory symptoms and small airway abnormalities in 166 symptomatic WTC dust-exposed patients. Forced oscillation testing (FOT) and respiratory symptoms were assessed during MCT. FOT parameters included resistance at 5 and 20 Hz (R5 and R20 ) and the R5 minus R20 (R5-20 )...
September 2016: American Journal of Industrial Medicine
Nikolina Icitovic, Lynn C Onyebeke, Sylvan Wallenstein, Christopher R Dasaro, Denise Harrison, Jieying Jiang, Julia R Kaplan, Roberto G Lucchini, Benjamin J Luft, Jacqueline M Moline, Lakshmi Pendem, Moshe Shapiro, Iris G Udasin, Andrew C Todd, Susan L Teitelbaum
BACKGROUND: There is increasing concern about the obesity epidemic in the United States. Obesity is a potential risk factor for a number of chronic diseases, including gastroesophageal reflux disease (GERD). This analysis examined whether body mass index (BMI) was associated with physician-diagnosed GERD in World Trade Center (WTC) general responders. METHODS: 19,819 WTC general responders were included in the study. Cox proportional hazards regression models were used to compare time to GERD diagnosis among three BMI groups (normal (<25 kg/m(2) ), overweight (≥25 and <30 kg/m(2) ), and obese (≥30 kg/m(2) ))...
September 2016: American Journal of Industrial Medicine
Jacqueline M Moline, Mary Ann McLaughlin, Simonette T Sawit, Cynara Maceda, Lori B Croft, Martin E Goldman, Mario J Garcia, Rupa L Iyengar, Mark Woodward
BACKGROUND: Law enforcement officers (LEOs) experience high rates of cardiovascular events compared with the general US population. Metabolic syndrome (MetS) confers an increased risk of cardiovascular disease and all-cause mortality. Data regarding MetS among LEOs are limited. METHODS: We sought to determine the prevalence of MetS and its associated risk factors as well as gender differences among LEOs who participated in the World Trade Center (WTC) Law Enforcement Cardiovascular Screening (LECS) Program from 2008 to 2010...
September 2016: American Journal of Industrial Medicine
Lisa M Gargano, Angela Nguyen, Laura DiGrande, Robert M Brackbill
BACKGROUND: Studies of individuals directly exposed to the World Trade Center (WTC) terrorist attacks of September 11, 2001 have found increased risk for post-traumatic stress disorder (PTSD) and binge drinking (BD). No long-term studies have been conducted on one highly exposed group, WTC tower evacuees. METHODS: The study sample included 7,695 adult civilians in the WTC Health Registry. Logistic regression was used to examine the odds of PTSD and BD in 1,946 towers evacuees compared to 5,749 others in nearby buildings or on the street...
September 2016: American Journal of Industrial Medicine
William Moir, Rachel Zeig-Owens, Robert D Daniels, Charles B Hall, Mayris P Webber, Nadia Jaber, James H Yiin, Theresa Schwartz, Xiaoxue Liu, Madeline Vossbrinck, Kerry Kelly, David J Prezant
BACKGROUND: We previously reported a modest excess of cancer in World Trade Center (WTC)-exposed firefighters versus the general population. This study aimed to separate the potential carcinogenic effects of firefighting and WTC exposure by comparing to a cohort of non-WTC-exposed firefighters. METHODS: Relative rates (RRs) for all cancers combined and individual cancer subtypes from 9/11/2001 to 12/31/2009 were modeled using Poisson regression comparing 11,457 WTC-exposed firefighters to 8,220 urban non-WTC-exposed firefighters...
September 2016: American Journal of Industrial Medicine
Jiehui Li, Robert M Brackbill, Tim S Liao, Baozhen Qiao, James E Cone, Mark R Farfel, James L Hadler, Amy R Kahn, Kevin J Konty, Leslie T Stayner, Steven D Stellman
BACKGROUND: Cancer incidence in exposed rescue/recovery workers (RRWs) and civilians (non-RRWs) was previously reported through 2008. METHODS: We studied occurrence of first primary cancer among World Trade Center Health Registry enrollees through 2011 using adjusted standardized incidence ratios (SIRs), and the WTC-exposure-cancer association, using Cox proportional hazards models. RESULTS: All-cancer SIR was 1.11 (95% confidence interval (CI) 1...
September 2016: American Journal of Industrial Medicine
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