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https://www.readbyqxmd.com/read/28061835/a-comparative-assessment-of-major-international-disasters-the-need-for-exposure-assessment-systematic-emergency-preparedness-and-lifetime-health-care
#1
Roberto G Lucchini, Dana Hashim, Sushma Acquilla, Angela Basanets, Pier Alberto Bertazzi, Andrey Bushmanov, Michael Crane, Denise J Harrison, William Holden, Philip J Landrigan, Benjamin J Luft, Paolo Mocarelli, Nailya Mazitova, James Melius, Jacqueline M Moline, Koji Mori, David Prezant, Joan Reibman, Dori B Reissman, Alexander Stazharau, Ken Takahashi, Iris G Udasin, Andrew C Todd
BACKGROUND: The disasters at Seveso, Three Mile Island, Bhopal, Chernobyl, the World Trade Center (WTC) and Fukushima had historic health and economic sequelae for large populations of workers, responders and community members. METHODS: Comparative data from these events were collected to derive indications for future preparedness. Information from the primary sources and a literature review addressed: i) exposure assessment; ii) exposed populations; iii) health surveillance; iv) follow-up and research outputs; v) observed physical and mental health effects; vi) treatment and benefits; and vii) outreach activities...
January 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28030758/world-trade-center-health-program-amendments-to-definitions-appeals-and-other-requirements-final-rule
#2
(no author information available yet)
In 2011 and 2012, the Secretary, Department of Health and Human Services (HHS), promulgated regulations designed to govern the World Trade Center (WTC) Health Program (Program), including the processes by which eligible responders and survivors may apply for enrollment in the Program, obtain health monitoring and treatment for WTC-related health conditions, and appeal enrollment and treatment decisions, as well as a process to add new conditions to the List of WTC-Related Health Conditions (List). After using the regulations for a number of years, the Administrator of the WTC Health Program identified potential improvements to certain existing provisions, including, but not limited to, appeals of enrollment, certification, and treatment decisions, as well as the procedures for the addition of health conditions for WTC Health Program coverage...
15, 2016: Federal Register
https://www.readbyqxmd.com/read/28013272/trauma-focused-smoking-cessation-for-smokers-exposed-to-the-world-trade-center-disaster-a-randomized-clinical-trial
#3
Adam Gonzalez, Fred Friedberg, Xiaotong Li, Michael J Zvolensky, Evelyn J Bromet, Brittain L Mahaffey, Anka A Vujanovic, Benjamin J Luft, Roman Kotov
INTRODUCTION: The main objective was to evaluate the efficacy of an 8-session, group-based comprehensive smoking cessation and trauma management (CSC-T) treatment among daily smokers (≥ 5 cigarettes/day) exposed to the WTC disaster with elevated WTC-related PTSD symptoms. METHODS: Participants (N=90) were randomly assigned to CSC-T (N=44; 63.6% White; 27.3% female; mean age = 51.32±7.87) or comprehensive smoking cessation (CSC) alone (N=46; 71.7% White; 28.3% female; mean age=48...
December 24, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28010830/anatomical-features-of-the-interscapular-area-where-wet-cupping-therapy-is-done-and-its-possible-relation-to-acupuncture-meridians
#4
REVIEW
Roshanak Ghods, Nasrin Sayfouri, Mohammad Hossein Ayati
Although wet cupping has been a treatment for centuries, its mechanism of action is not well understood. Because the anatomical features of the wet-cupping area might play a role in its mechanism, we focus on the features of the interscapular area in which a common type of wet-cupping therapy (WCT), called Hijamat-e-Aam in Iranian medicine, is usually applied and discuss the possible relation of those features to the acupuncture meridians. We gathered and analyzed data from reliable textbooks on modern medicine with a focus on the anatomical features of the interscapular area, topics related to WTC in Iranian medicine, and acupuncture sources obtained by searching PubMed, Google-Scholar, and Science Direct...
December 2016: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/27986442/world-trade-center-wtc-dust-exposure-in-mice-is-associated-with-inflammation-oxidative-stress-and-epigenetic-changes-in-the-lung
#5
Vasanthi R Sunil, Kinal N Vayas, Mingzhu Fang, Helmut Zarbl, Christopher Massa, Andrew J Gow, Jessica A Cervelli, Howard Kipen, Robert J Laumbach, Paul J Lioy, Jeffrey D Laskin, Debra L Laskin
Exposure to World Trade Center (WTC) dust has been linked to respiratory disease in humans. In the present studies we developed a rodent model of WTC dust exposure to analyze lung oxidative stress and inflammation, with the goal of elucidating potential epigenetic mechanisms underlying these responses. Exposure of mice to WTC dust (20μg, i.t.) was associated with upregulation of heme oxygenase-1 and cyclooxygenase-2 within 3days, a response which persisted for at least 21days. Whereas matrix metalloproteinase was upregulated 7days post-WTC dust exposure, IL-6RA1 was increased at 21days; conversely, expression of mannose receptor, a scavenger receptor important in particle clearance, decreased...
December 13, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27981413/evaluating-the-impact-of-an-anti-stigma-intervention-on-pharmacy-students-willingness-to-counsel-people-living-with-mental-illness
#6
Benita A Bamgbade, Jamie C Barner, Kentya H Ford
Third-year pharmacy students (n = 88) participated in an anti-stigma intervention program consisting of presentations, videos, discussion and active-learning exercises. Willingness to counsel (WTC) people with mental illness (MI) was evaluated using immediate pre and post-tests comparing diabetes, depression and schizophrenia. At pre-test, WTC diabetes was highest (higher = increased WTC) while schizophrenia was the lowest. There were no statistically significant differences between pre/post-test WTC for diabetes and depression, while schizophrenia WTC increased significantly (p < 0...
December 15, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27923492/hydrogen-bonding-interactions-and-enthalpy-relaxation-in-sugar-protein-glasses
#7
Bulat Sydykov, Harriëtte Oldenhof, Harald Sieme, Willem F Wolkers
In this study, hydrogen bonding interactions and enthalpy relaxation phenomena of sugar and sugar/protein glasses have been studied using Fourier transform infrared spectroscopy and differential scanning calorimetry. The sugar OH band in Fourier transform infrared spectra was used to derive the glass transition temperature, Tg, and the wavenumber-temperature coefficient (WTC) of the OH band. A study on mixtures of sucrose and albumin revealed that the glass transition temperature and strength of hydrogen bonds increased with increasing percentages of albumin...
December 3, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27905829/post-traumatic-stress-disorder-dimensions-and-asthma-morbidity-in-world-trade-center-rescue-and-recovery-workers
#8
Irina Mindlis, Esperanza Morales-Raveendran, Emily Goodman, Kevin Xu, Clara Vila-Castelar, Kristine Keller, Ginger Crawford, Shynah James, Craig Katz, Laura E Crowley, Rafael E de la Hoz, Steven Markowitz, Juan P Wisnivesky
Objective Using data from a cohort of World Trade Center (WTC) rescue and recovery workers with asthma, we assessed whether meeting criteria for post-traumatic stress disorder (PTSD), sub- PTSD and for specific PTSD symptom dimensions are associated with increased asthma morbidity. Methods Participants underwent a Structured Clinical Interview for Diagnostic and Statistical Manual to assess presence of PTSD following DSM-IV criteria during in-person interviews between December 2013 and April 2015. We defined sub-threshold PTSD as meeting criteria for two of three symptom dimensions: re-experiencing, avoidance, or hyper-arousal...
December 1, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27898584/prostate-cancer-characteristics-in-the-world-trade-center-cohort-2002-2013
#9
Dana Hashim, Paolo Boffetta, Matthew Galsky, William Oh, Roberto Lucchini, Michael Crane, Benjamin Luft, Jaqueline Moline, Iris Udasin, Denise Harrison, Emanuela Taioli
An increased incidence of prostate cancer was reported in three cohorts of World Trade Center (WTC) respondents. It is uncertain whether this increase is because of WTC-related exposures or enhanced surveillance. Prostate cancer cases (2002-2013) were obtained from the WTC Health Program. Age, race, and Gleason score distribution were compared with New York State Cancer Registry cases from the same time period. Multivariate models were adjusted for age and race. Analyses of clinical characteristics of prostate cancer cases within the cohort were also carried out, adjusting for age, race, and WTC exposure categories...
November 24, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27833099/proteomic-characterization-of-the-world-trade-center-dust-activated-mdig-and-c-myc-signaling-circuit-linked-to-multiple-myeloma
#10
Kai Wu, Lingzhi Li, Chitra Thakur, Yongju Lu, Xiangmin Zhang, Zhengping Yi, Fei Chen
Several epidemiological studies suggested an increased incidence rate of multiple myeloma (MM) among first responders and other individuals who exposed to World Trade Center (WTC) dust. In this report, we provided evidence showing that WTC dust is potent in inducing mdig protein and/or mRNA in bronchial epithelial cells, B cells and MM cell lines. An increased mdig expression in MM bone marrow was observed, which is associated with the disease progression and prognosis of the MM patients. Through integrative genomics and proteomics approaches, we further demonstrated that mdig directly interacts with c-myc and JAK1 in MM cell lines, which contributes to hyperactivation of the IL-6-JAK-STAT3 signaling important for the pathogenesis of MM...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27820766/neurologic-evaluations-of-patients-exposed-to-the-world-trade-center-disaster
#11
Mark M Stecker, Huiying Yu, Renee Barlev, Michael Marmor, Marc Wilkenfeld
OBJECTIVE: The aim of this study was to describe the clinical phenotype of a limited group of responders and survivors of the World Trade Center (WTC) disaster who were referred for the evaluation of neuropathic symptoms. METHODS: Sixteen patients with WTC exposure were referred to a neurologist for evaluation. All had a neurologic examination. Most had electromyogram and nerve conduction testing/nerve conduction studies as well as appropriate imaging and blood tests...
November 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27751859/abnormal-dynamics-of-cortical-resting-state-functional-connectivity-in-chronic-headache-patients
#12
Zewei Wang, Qing Yang, Li Min Chen
The goals of this study are to characterize the temporal dynamics of inter-regional connectivity of the brain in chronic headache (CH) patients versus their age/gender matched controls (CONCH, n=28 pairs), and to determine whether dynamic measures reveal additional features to static functional connectivity and correlate with psychometric scores. Cortical thickness and inter-regional resting state fMRI connectivity were quantified and compared between CH and CONCH groups. Six cortical regions of interest (ROI) pairs that exhibited correlated cortical thickness and static functional connectivity abnormalities were selected for temporal dynamic analysis...
October 14, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27717301/respirable-dust-and-silica-exposure-among-world-trade-center-cleanup-workers
#13
Brian T Pavilonis, Franklin E Mirer
The cleanup effort following the destruction of the World Trade Center (WTC) was unprecedented and involved removal of 1.8 million tons of rubble over a nine month period. Work at the site occurred 24 hours a day, seven days a week and involved thousands of workers during the process. The Occupational Safety and Health Administration (OSHA) conducted personal and area exposure sampling during the cleanup of the site. Secondary data analysis was performed on OSHA air sampling data for respirable dust and silica from September 2001 to June 2002 at the WTC recovery site to characterize workers' exposure...
October 7, 2016: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27626057/cognitive-impairment-among-world-trade-center-responders-long-term-implications-of-re-experiencing-the-9-11-terrorist-attacks
#14
Sean A P Clouston, Roman Kotov, Robert H Pietrzak, Benjamin J Luft, Adam Gonzalez, Marcus Richards, Camilo J Ruggero, Avron Spiro, Evelyn J Bromet
INTRODUCTION: During the World Trade Center (WTC) attacks, responders who helped in search, rescue, and recovery endured multiple traumatic and toxic exposures. One-fifth subsequently developed post-traumatic stress disorder (PTSD). PTSD has been linked to dementia in veterans. This study examined the association between WTC-related PTSD and cognitive impairment (CI) in WTC responders. METHODS: A one-third sample of responders (N = 818) reporting for annual monitoring visits were screened for cognitive impairment and dementia using the Montreal Cognitive Assessment from January 2014-April 2015...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27623049/latent-typologies-of-posttraumatic-stress-disorder-in-world-trade-center-responders
#15
Sarah R Horn, Robert H Pietrzak, Clyde Schechter, Evelyn J Bromet, Craig L Katz, Dori B Reissman, Roman Kotov, Michael Crane, Denise J Harrison, Robin Herbert, Benjamin J Luft, Jacqueline M Moline, Jeanne M Stellman, Iris G Udasin, Philip J Landrigan, Michael J Zvolensky, Steven M Southwick, Adriana Feder
Posttraumatic stress disorder (PTSD) is a debilitating and often chronic psychiatric disorder. Following the 9/11/2001 World Trade Center (WTC) attacks, thousands of individuals were involved in rescue, recovery and clean-up efforts. While a growing body of literature has documented the prevalence and correlates of PTSD in WTC responders, no study has evaluated predominant typologies of PTSD in this population. Participants were 4352 WTC responders with probable WTC-related DSM-IV PTSD. Latent class analyses were conducted to identify predominant typologies of PTSD symptoms and associated correlates...
September 2, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27619982/effects-of-effort-and-difficulty-on-human-preference-for-a-stimulus-investigation-of-the-within-trial-contrast
#16
Masashi Tsukamoto, Kenichiro Kohara, Koji Takeuchi
The within-trial contrast hypothesis (WTC) provides a more parsimonious explanation for the phenomenon that humans and animals prefer outcomes that follow more effortful events to outcomes that follow less effortful events (Zentall, 2013). We conducted two WTC experiments with human adults. In Experiment 1, we manipulated the difficulty of a preceding event by varying the interresponse time and the limited-hold interval during differential reinforcement with a low response rate schedule, to examine the effect of effort on the preference for the subsequent stimuli...
September 12, 2016: Learning & Behavior
https://www.readbyqxmd.com/read/27608280/fatigue-and-sleep-among-employees-with-prospective-increase-in-work-time-control-a-1-year-observational-study-with-objective-assessment
#17
Tomohide Kubo, Masaya Takahashi, Xinxin Liu, Hiroki Ikeda, Fumiharu Togo, Akihito Shimazu, Katsutoshi Tanaka, Naoki Kamata, Yoshiko Kubo, Junko Uesugi
OBJECTIVES: This observational study aimed to determine how 1-year changes in work time control (WTC) have an impact upon objectively measured fatigue and sleep among employees. METHODS: Thirty-nine employees were divided into two groups according to whether or not their WTC increased from baseline to 1 year later. Psychomotor vigilance task (PVT) and wrist actigraphy were used to objectively measure fatigue and sleep, respectively. Self-reported outcomes were also measured...
September 6, 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27582483/effect-of-asthma-and-ptsd-on-persistence-and-onset-of-gastroesophageal-reflux-symptoms-among-adults-exposed-to-the-september-11-2001-terrorist-attacks
#18
Jiehui Li, Robert M Brackbill, Hannah T Jordan, James E Cone, Mark R Farfel, Steven D Stellman
BACKGROUND: Little is known about the direction of causality among asthma, posttraumatic stress disorder (PTSD), and onset of gastroesophageal reflux symptoms (GERS) after exposure to the 9/11/2001 World Trade Center (WTC) disaster. METHODS: Using data from the WTC Health Registry, we investigated the effects of early diagnosed post-9/11 asthma and PTSD on the late onset and persistence of GERS using log-binomial regression, and examined whether PTSD mediated the asthma-GERS association using structural equation modeling...
September 2016: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/27582482/asthma-among-staten-island-fresh-kills-landfill-and-barge-workers-following-the-september-11-2001-world-trade-center-terrorist-attacks
#19
James E Cone, Sukhminder Osahan, Christine C Ekenga, Sara A Miller-Archie, Steven D Stellman, Monique Fairclough, Stephen M Friedman, Mark R Farfel
BACKGROUND: Although airborne respiratory irritants at the World Trade Center (WTC) site have been associated with asthma among WTC Ground Zero workers, little is known about asthma associated with work at the Staten Island landfill or barges. METHODS: To evaluate the risk of asthma first diagnosed among Staten Island landfill and barge workers, we conducted a survey and multivariable logistic regression analysis regarding the association between Staten Island landfill and barge-related work exposures and the onset of post-9/11 asthma...
September 2016: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/27582481/biomarkers-of-patient-intrinsic-risk-for-upper-and-lower-airway-injury-after-exposure-to-the-world-trade-center-atrocity
#20
REVIEW
Rachel Zeig-Owens, Anna Nolan, Barbara Putman, Ankura Singh, David J Prezant, Michael D Weiden
BACKGROUND: High rates of upper and lower airways disease have occurred in Fire Department of the City of New York (FDNY) workers exposed to the World Trade Center (WTC) disaster site. Most experienced acute declines in pulmonary function, and some continued to experience decline over 14 years of follow-up. Similarly, some with rhinosinusitis had symptoms requiring sinus surgery. AIM: To increase generalizability of biomarker investigation, we describe biomarkers of risk for upper and lower airway injury that do not require stored serum...
September 2016: American Journal of Industrial Medicine
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