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Intermittent mechanical strain

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https://www.readbyqxmd.com/read/27876231/paternal-preconception-alcohol-exposure-imparts-intergenerational-alcohol-related-behaviors-to-male-offspring-on-a-pure-c57bl-6j-background
#1
Gregory R Rompala, Andrey Finegersh, Michelle Slater, Gregg E Homanics
While alcohol use disorder (AUD) is a highly heritable condition, the basis of AUD in families with a history of alcoholism is difficult to explain by genetic variation alone. Emerging evidence suggests that parental experience prior to conception can impact inheritance of complex behaviors in offspring via non-genomic (epigenetic) mechanisms. For instance, male C57BL/6J (B6) mice exposed to chronic intermittent vapor ethanol (CIE) prior to mating with Strain 129S1/SvImJ ethanol-naïve females produce male offspring with reduced ethanol drinking preference, increased ethanol sensitivity, and increased BDNF expression in the ventral tegmental area (VTA)...
November 5, 2016: Alcohol
https://www.readbyqxmd.com/read/27852613/vitamin-c-enriched-gelatin-supplementation-before-intermittent-activity-augments-collagen-synthesis
#2
Gregory Shaw, Ann Lee-Barthel, Megan Lr Ross, Bing Wang, Keith Baar
BACKGROUND: Musculoskeletal injuries are the most common complaint in active populations. More than 50% of all injuries in sports can be classified as sprains, strains, ruptures, or breaks of musculoskeletal tissues. Nutritional and/or exercise interventions that increase collagen synthesis and strengthen these tissues could have an important effect on injury rates. OBJECTIVE: This study was designed to determine whether gelatin supplementation could increase collagen synthesis...
November 16, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27647442/exercise-induced-heat-stress-disrupts-the-shear-dilatory-relationship
#3
Stephen J Ives, Wesley K Lefferts, Margret Wharton, Patricia C Fehling, Denise L Smith
What is the central question of this study? Although heat stress is known to increase cardiovascular strain, no study, to date, had explored the potential impact of exercise-induced heat stress on vascular function. What is the main finding and its importance? We found that acute exercise tended to reduce flow-mediated dilatation (FMD), owing in part to reduced reactive hyperaemia/shear stimulus; thus, when FMD is normalized to shear no postexercise deficit exists. Exercise-induced heat stress increased reactive hyperaemia, shear rate, coupled with a sustained FMD postexercise, suggests that exercise-induced heat stress increases the amount of shear stimulus to elicit a similar response, indicating reduced vascular responsiveness, or reserve, which might increase cardiovascular susceptibility...
December 1, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27627724/intermittent-cyclic-mechanical-tension-promotes-degeneration-of-endplate-cartilage-via-the-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway-an-in-vivo-study
#4
Liang Xiao, Hong-Guang Xu, Hong Wang, Ping Liu, Chen Liu, Xiang Shen, Tao Zhang, Yong-Ming Xu
OBJECTIVE: To establish a rabbit model for investigating the effects of intermittent cyclic mechanical tension (ICMT) on promoting degeneration of endplate cartilage. METHODS: Forty New Zealand white rabbits were subjected to surgery and randomly divided into three equal groups as follows: control group (no treatment, n = 10), sham group (animals underwent a sham operation but were not subjected to mechanical tensile strain, n = 15) and loaded group (discs were subjected to 1...
August 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/27494696/assessment-of-intermittently-loaded-woodchip-and-sand-filters-to-treat-dairy-soiled-water
#5
J G Murnane, R B Brennan, M G Healy, O Fenton
Land application of dairy soiled water (DSW) is expensive relative to its nutrient replacement value. The use of aerobic filters is an effective alternative method of treatment and potentially allows the final effluent to be reused on the farm. Knowledge gaps exist concerning the optimal design and operation of filters for the treatment of DSW. To address this, 18 laboratory-scale filters, with depths of either 0.6 m or 1 m, were intermittently loaded with DSW over periods of up to 220 days to evaluate the impacts of depth (0...
October 15, 2016: Water Research
https://www.readbyqxmd.com/read/27479500/the-effect-of-local-hydration-environment-on-the-mechanical-properties-and-unloaded-temporal-changes-of-isolated-porcine-annular-samples
#6
Kristina M Gruevski, Chad E Gooyers, Thomas Karakolis, Jack P Callaghan
Preventing dehydration during in vitro testing of isolated layers of annulus fibrosus tissue may require different test conditions than functional spine units. The purpose of the study was twofold: (A) to quantify changes in mass and thickness of multilayer annulus samples in four hydration environments over 120 min; and (B) to quantify cycle-varying biaxial tensile properties of annulus samples in the four environments. The environments included a saline bath, air, relative humidity control, and misting combined with controlled humidity...
October 1, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27425261/dopamine-synthesis-in-alcohol-drinking-prone-and-resistant-mouse-strains
#7
Cody A Siciliano, Jason L Locke, Tiffany A Mathews, Marcelo F Lopez, Howard C Becker, Sara R Jones
Alcoholism is a prevalent and debilitating neuropsychiatric disease, and much effort has been aimed at elucidating the neurobiological mechanisms underlying maladaptive alcohol drinking in an effort to design rational treatment strategies. In preclinical literature, the use of inbred mouse lines has allowed for the examination of ethanol effects across vulnerable and resistant phenotypes. C57BL/6J mice consistently show higher rates of ethanol drinking compared to most mouse strains. Conversely, DBA/2J mice display low rates of ethanol consumption...
June 11, 2016: Alcohol
https://www.readbyqxmd.com/read/27357508/combined-effects-of-proinflammatory-cytokines-and-intermittent-cyclic-mechanical-strain-in-inhibiting-osteogenicity-in-human-periodontal-ligament-cells
#8
Chaofan Sun, Lijiao Chen, Xinlian Shi, Zhensheng Cao, Bibo Hu, Wenbin Yu, Manman Ren, Rongdang Hu, Hui Deng
Mechanical strain plays an important role in bone formation and resorption during orthodontic tooth movement. The mechanism has not been fully studied, and the process becomes complex with increased amounts of periodontal patients seeking orthodontic care. Our aims were to elucidate the combined effects of proinflammatory cytokines and intermittent cyclic strain (ICS) on the osteogenic capacity of human periodontal ligament cells. Cultured human periodontal ligament cells were exposed to proinflammatory cytokines (interleukin-1β 5 ng/mL and tumor necrosis factor-α 10 ng/mL) for 1 and 5 days, and ICS (0...
September 2016: Cell Biology International
https://www.readbyqxmd.com/read/27294556/aflatoxin-b1-degradation-by-liquid-cultures-and-lysates-of-three-bacterial-strains
#9
Oluwafemi Ayodeji Adebo, Patrick Berka Njobeh, Sibusiso Sidu, Matsobane Godfrey Tlou, Vuyo Mavumengwana
Aflatoxin contamination remains a daunting issue to address in food safety. In spite of the efforts geared towards prevention and elimination of this toxin, it still persists in agricultural commodities. This has necessitated the search for other measures such as microbial degradation to combat this hazard. In this study, we investigated the biodegradation of aflatoxin B1 (AFB1), using lysates of three bacterial strains (Pseudomonas anguilliseptica VGF1, Pseudomonas fluorescens and Staphylococcus sp. VGF2) isolated from a gold mine aquifer...
September 16, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/26914883/what-quantitative-mechanical-loading-stimulates-in-vitro-cultivation-best
#10
Jerry Natenstedt, Aimee C Kok, Jenny Dankelman, Gabrielle Jm Tuijthof
Articular cartilage has limited regeneration capacities. One of the factors that appear to affect the in vitro cultivation of articular cartilage is mechanical stimulation. So far, no combination of parameters has been identified that offers the best results. The goal is to review the literature in search of the best available set of quantitative mechanical stimuli that lead to optimal in vitro cultivation.The databases Scopus and PubMed were used to survey the literature, and strict in- and exclusion criteria were applied regarding the presence of quantitative data...
December 2015: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/26913467/p120-catenin-protects-endplate-chondrocytes-from-intermittent-cyclic-mechanical-tension-induced-degeneration-by-inhibiting-the-expression-of-rhoa-rock-1-signaling-pathway
#11
Hong-Guang Xu, Ming-Ming Ma, Quan Zheng, Xiang Shen, Hong Wang, Shu-Feng Zhang, Jia-Jia Xu, Chuan-Dong Wang, Xiao-Ling Zhang
STUDY DESIGN: The changes of endplate chondrocytes induced by intermittent cyclic mechanical tension (ICMT) were observed by realtime reverse transcription-polymerase chain reaction, immunofluorescence, and Western blot analysis. OBJECTIVE: To investigate the role of RhoA/ROCK-1 signaling pathway and E-cadherin/P120-catenin complex in endplate chondrocytes degeneration induced by ICMT. SUMMARY OF BACKGROUND DATA: ICMT can induce the endplate chondrocyte degeneration...
August 15, 2016: Spine
https://www.readbyqxmd.com/read/26888646/what-are-the-physiological-mechanisms-for-post-exercise-cold-water-immersion-in-the-recovery-from-prolonged-endurance-and-intermittent-exercise
#12
REVIEW
Mohammed Ihsan, Greig Watson, Chris R Abbiss
Intense training results in numerous physiological perturbations such as muscle damage, hyperthermia, dehydration and glycogen depletion. Insufficient/untimely restoration of these physiological alterations might result in sub-optimal performance during subsequent training sessions, while chronic imbalance between training stress and recovery might lead to overreaching or overtraining syndrome. The use of post-exercise cold water immersion (CWI) is gaining considerable popularity among athletes to minimize fatigue and accelerate post-exercise recovery...
August 2016: Sports Medicine
https://www.readbyqxmd.com/read/26842469/replication-of-human-herpesviruses-is-associated-with-higher-hiv-dna-levels-during-antiretroviral-therapy-started-at-early-phases-of-hiv-infection
#13
Sara Gianella, Christy M Anderson, Susanna R Var, Michelli F Oliveira, Steven M Lada, Milenka V Vargas, Marta Massanella, Susan J Little, Douglas D Richman, Matthew C Strain, Josué Pérez-Santiago, Davey M Smith
UNLABELLED: Asymptomatic replication of human herpesviruses (HHV) is frequent in HIV-infected men and is associated with increased T-cell activation and HIV disease progression. We hypothesized that the presence of replication of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) (the most frequently detected HHV) might influence HIV DNA decay during antiretroviral therapy (ART). We investigated 607 peripheral blood mononuclear cell (PBMC) samples from 107 CMV-seropositive, HIV-infected men who have sex with men, who started ART within a median of 3 months from their estimated date of infection (EDI) and were monitored for a median of 19 months thereafter...
April 2016: Journal of Virology
https://www.readbyqxmd.com/read/26709656/prolonged-cyclic-strain-inhibits-human-endothelial-cell-growth
#14
Kelly J Peyton, Xiao-ming Liu, William Durante
The vascular endothelium is continuously exposed to cyclic mechanical strain due to the periodic change in vessel diameter as a result of pulsatile blood flow. Since emerging evidence indicates the cyclic strain plays an integral role in regulating endothelial cell function, the present study determined whether application of a physiologic regimen of cyclic strain (6% at 1 hertz) influences the proliferation of human arterial endothelial cells. Prolonged exposure of human dermal microvascular or human aortic endothelial cells to cyclic strain for up to 7 days resulted in a marked decrease in cell growth...
2016: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/26661573/mechanical-actuation-systems-for-the-phenotype-commitment-of-stem-cell-based-tendon-and-ligament-tissue-substitutes
#15
REVIEW
Marco Govoni, Claudio Muscari, Joseph Lovecchio, Carlo Guarnieri, Emanuele Giordano
High tensile forces transmitted by tendons and ligaments make them susceptible to tearing or complete rupture. The present standard reparative technique is the surgical implantation of auto- or allografts, which often undergo failure.Currently, different cell types and biomaterials are used to design tissue engineered substitutes. Mechanical stimulation driven by dedicated devices can precondition these constructs to a remarkable degree, mimicking the local in vivo environment. A large number of dynamic culture instruments have been developed and many appealing results collected...
April 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/26657171/adolescent-methylphenidate-treatment-differentially-alters-adult-impulsivity-and-hyperactivity-in-the-spontaneously-hypertensive-rat-model-of-adhd
#16
S S Somkuwar, K M Kantak, M T Bardo, L P Dwoskin
Impulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD). Impulsivity is expressed as reduced response inhibition capacity, an executive control mechanism that prevents premature execution of an intermittently reinforced behavior. During methylphenidate treatment, impulsivity and hyperactivity are decreased in adolescents with ADHD, but there is little information concerning levels of impulsivity and hyperactivity in adulthood after adolescent methylphenidate treatment is discontinued...
February 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/26351659/periodontal-biological-events-associated-with-orthodontic-tooth-movement-the-biomechanics-of-the-cytoskeleton-and-the-extracellular-matrix
#17
REVIEW
L Feller, R A G Khammissa, I Schechter, A Moodley, G Thomadakis, J Lemmer
The mechanical stimuli generated by orthodontic forces cause deformation of extracellular matrices and cells, vascular changes, inflammation, and the release of active biological agents generating a complex multifactorial sequence of biological events culminating in bone remodelling enabling orthodontic tooth movement. Orthodontic forces on the teeth generate stresses in periodontal tissues according to a number of variables including the type (continuous, interrupted, or intermittent), magnitude, direction, and frequency of the applied load...
2015: TheScientificWorldJournal
https://www.readbyqxmd.com/read/26300722/repeated-vapor-ethanol-exposure-induces-transient-histone-modifications-in-the-brain-that-are-modified-by-genotype-and-brain-region
#18
Andrey Finegersh, Carolyn Ferguson, Seth Maxwell, David Mazariegos, Daniel Farrell, Gregg E Homanics
BACKGROUND: Emerging research implicates ethanol (EtOH)-induced epigenetic modifications in regulating gene expression and EtOH consumption. However, consensus on specific epigenetic modifications induced by EtOH has not yet emerged, making it challenging to identify mechanisms and develop targeted treatments. We hypothesized that chronic intermittent EtOH (CIE) induces persistent changes in histone modifications across the cerebral cortex (CCx), nucleus accumbens (NAc), and prefrontal cortex (PFC), and that these histone modifications are altered in a knock-in mouse strain with altered sensitivity to EtOH...
2015: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/26299771/mechanical-strain-promotes-osteogenesis-of-bmscs-from-ovariectomized-rats-via-the-erk1-2-but-not-p38-or-jnk-mapk-signaling-pathways
#19
P Zhang, Q Dai, N Ouyang, X Yang, J Wang, S Zhou, N He, B Fang, L Jiang
Osteoporosis has become a world-wide health problem. As a promising intervention, mechanical strain is considered to be an important factor in bone remodeling. However, the underlying mechanisms are still not clarified clearly. In the present study, we aim to investigate the possible mechanism by which mechanical stimulation induces osteogenic differentiation of bone mesenchymal stem cells (BMSCs) from ovariectomized rats (OVX BMSCs). The results demonstrated that intermittent mechanical strain (IMS) promoted osteogenic differentiation of OVX BMSCs by activating Runt-related transcription factor 2 (Runx2)...
2015: Current Molecular Medicine
https://www.readbyqxmd.com/read/26112248/intermittent-stretching-and-osteogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-via-the-p38mapk-osterix-signaling-pathway
#20
Wen-lin Xiao, Dai-zun Zhang, Cun-hui Fan, Bao-jun Yu
AIMS: The relationship between the p38MAPK signaling pathway and osterix in osteogenic differentiation of BMMSCs subjected to intermittent stretching was investigated. METHODS: BMMSCs derived from C57BL/6J mice were divided into the following groups: 1) control, 2) stretch, and 3) SB203580+stretch (SB203580 is a p38MAPK signal pathway inhibitor). BMMSCs were exposed to an intermittent mechanical strain of 0.8% (8000μ strain) at 0.5 Hz, twice a day for 30 min each application...
2015: Cellular Physiology and Biochemistry
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