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Odile Lalainasoa Rivoarilala, Benoît Garin, Felamboahangy Andriamahery, Jean Marc Collard
BACKGROUND: The prevalence of bacteria producing CTX-M Extended-Spectrum β-lactamases (ESBLs) has increased around the world and some of them became a major cause of infections such as bloodstream or urinary tract infections (UTI). We developed a loop-mediated isothermal amplification (LAMP) assay for a simple, rapid and sensitive detection of the four most common CTX-M groups, namely CTX-M groups 1, 2, 8 and 9. METHODS: LAMP primers targeting the four ESBLs CTX-M groups were designed using the Primer Explorer V4 software...
2018: PloS One
Rosa Park, Justin Gyorfi, Kalyan Dewan, Girish Kirimanjeswara, Joseph Y Clark, Matthew G Kaag, Kathleen Lehman, Jay D Raman
PURPOSE: To report outcomes 5 years after a resident quality initiative incorporated topical rectal antiseptic into our ultrasound-guided prostate needle biopsy (TRUS PNB) protocol. METHODS: A chart review was conducted on 1007 men who underwent TRUS PNB between 2010 and 2017. Comparison groups include those who received a topical rectal antiseptic (N = 437) compared to those who did not (N = 570). Povidone-iodine (N = 303) or 4% chlorhexidine solution without alcohol (N = 134) were topical agents...
July 17, 2018: International Urology and Nephrology
Anna Faura Morros, Adriana Cuaresma González, Susanna Hernández-Bou, Victoria Trenchs Sainz de la Maza, Juan Antonio Camacho Diaz, Carles Luaces Cubells
INTRODUCTION: Several authors question the performance of systematic renal ultrasound after first urinary tract infection (UTI) in young children, given the high sensitivity of prenatal ultrasounds to detect major malformations and the low prevalence of clinical relevant findings. The aims of this study are to evaluate the yield of renal ultrasound performed after the first UTI in patients aged less than 2 years and to analyse potential risk factors (RF) of altered renal ultrasound. PATIENTS AND METHODS: Retrospective study, including patients aged less than 2 years diagnosed with UTI in the Emergency Department between July 2013 and December 2014...
July 12, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Jitendra A Sattigeri, Malvika Garg, Pragya Bhateja, Ajay Soni, Abdul Rehman Abdul Rauf, Mahendrakumar Gupta, Mahesh S Deshmukh, Tarun Jain, Nidhi Alekar, Tarani Kanta Barman, Paras Jha, Tridib Chaira, Ramesh B Bambal, Dilip J Upadhyay, Takahide Nishi
FimH is a type I fimbrial lectin located at the tip of type-1 pili of Gram-negative uropathogenic Escherichia coli (UPEC) guiding its ability to adhere and infect urothelial cells. Accordingly, blocking FimH with small molecule inhibitor is considered as a promising new therapeutic alternative to treat urinary tract infections caused by UPEC. Herein, we report that compounds having the S-glycosidic bond (thiomannosides) had improved metabolic stability and plasma exposures when dosed orally. Especially compound 5h showed the potential to inhibit biofilm formation and also to disrupt the preformed biofilm...
June 12, 2018: Bioorganic & Medicinal Chemistry Letters
Nicola Santoni, Angela Ng, Rachel Skews, Omar M Aboumarzouk
Background/Aims/Objectives: Women with recurrent urinary tract infections (UTIs) are commonly referred to urology outpatient clinics. However, there is no clear consensus in existing guidelines as to if, or how, these should be investigated. The primary outcome was to evaluate all available literature to determine the percentage of abnormal findings in non-pregnant women with recurrent simple UTIs. Secondary outcomes were to determine the percentage that were serious, consequential or incidental findings. METHODS: A full literature search was performed of the following databases: MEDLINE; Pubmed; Cochrane Central Register of Controlled Trials-CENTRAL; and ClinicalTrials...
July 17, 2018: Urologia Internationalis
İsa Yılmaz, Harun Peru, Fatma H Yılmaz, Tamer Sekmenli, İlhan Çiftçi, Fatih Kara
INTRODUCTION: The aim was to investigate the relationship between vesicoureteral reflux (VUR) and renal damage in non-febrile, febrile for the first time and recurrent urinary tract infection (UTI) patients. The secondary aim was to determine whether C-reactive protein (CRP) in febrile UTIs could be a predictor of renal scarring. POPULATION AND METHODS: This prospective study included non-febrile, febrile for the first time and recurrent pediatric UTI cases. The routine lab analyses comprised a complete blood count, urea, creatinine, fully automated urinalysis, urine culture and CRP analyses...
August 1, 2018: Archivos Argentinos de Pediatría
Elżbieta M Stefaniuk
The aim of this study was to evaluate the usefulness of chromogenic media for isolation of bacteria from urine and direct identification of UTI pathogens. A total of 100 urine specimens were inoculated on blood agar and MacConkey agar as a reference method and on the following media to be tested: chromID® CPS® Elite (CPSE, bioMérieux), CHROMagarTM Orientation (BioMaxima), BD CHROMagar Orientation Medium (ORI, Becton Dickinson), CHROMagarTM Orientation (ORIE, Graso) and Brillance UTI Clarity Agar (UTI C, Oxoid)...
June 30, 2018: Polish Journal of Microbiology
Junge Chen, Youchun Xu, He Yan, Yunzeng Zhu, Lei Wang, Yan Zhang, Ying Lu, Wanli Xing
Bacterial infections may cause severe diseases such as tuberculosis, sepsis, nephritis and cystitis. The rapid and sensitive detection of bacteria is a prerequisite for the treatment of these diseases. The current gold standard for bacterial identification is bacteriological culture. However, culture-based identification takes 3-7 days, which is time-consuming and laborious. In this study, bacteria in urine samples were enriched using a portable filter-based pipette. Then, a centrifugal chip was constructed to detect multiple pathogenic bacteria from urine samples by integrating the DNA extraction, multiplex recombinase polymerase amplification (RPA) and fluorescent detection together...
July 17, 2018: Lab on a Chip
Elisabet Guiral, Maria Jesús Pons, Delfino Vubil, Marta Marí-Almirall, Betuel Sigaúque, Sara Maria Soto, Pedro Luís Alonso, Joaquim Ruiz, Jordi Vila, Inácio Mandomando
Background: The emergence and spread of extended-spectrum β-lactamases (ESBLs), especially CTX-M, is an important public health problem with serious implications for low-income countries where second-line treatment is often unavailable. Knowledge of the local prevalence of ESBL is critical to define appropriate empirical therapeutic strategies for multidrug-resistant (MDR) organisms. This study aimed to assess and characterize the presence of ESBL and especially CTX-M-producing Escherichia coli MDR isolates from patients with urinary tract infections (UTIs) and bacteremia in a rural hospital in Mozambique...
2018: Infection and Drug Resistance
Jérémy Ranfaing, Catherine Dunyach-Remy, Laurence Louis, Jean-Philippe Lavigne, Albert Sotto
Uropathogenic Escherichia coli (UPEC), the most prevalent bacteria isolated in urinary tract infections (UTI), is now frequently resistant to antibiotics used to treat this pathology. The antibacterial properties of cranberry and propolis could reduce the frequency of UTIs and thus the use of antibiotics, helping in the fight against the emergence of antibiotic resistance. Transcriptomic profiles of a clinical UPEC strain exposed to cranberry proanthocyanidins alone (190 µg/mL), propolis alone (102.4 µg/mL) and a combination of both were determined...
July 16, 2018: Scientific Reports
Marguerite L Monogue, Sara Giovagnoli, Caterina Bissantz, Claudia Zampaloni, David P Nicolau
Urinary tract infections (UTIs) are a tremendous burden to the healthcare system due to the vast number of infections resulting in antibiotic therapy and/or hospitalization. Additionally, these infections are frequently caused by multi-drug resistant (MDR) organisms, limiting the availability of effective antimicrobials. Nacubactam is a novel non-β-lactam-β-lactamase inhibitor with in vitro activity against class A and class C β-lactamases. Nacubactam is being developed in combination with meropenem, providing broad-spectrum activity in addition to improved stability against common β-lactamases...
July 16, 2018: Antimicrobial Agents and Chemotherapy
Arman A Kahokehr, Michael A Granieri, George D Webster, Andrew C Peterson
INTRODUCTION: To evaluate the management of recurrence after urethroplasty for bulbar urethral stricture disease (BUSD) at our institution. METHODS: We performed an institution review board approved retrospective case study of our urethroplasty database to collect stricture-related and post-operative information with emphasis on recurrence after urethroplasty for BUSD between 1996-2012. Repair types included primary anastomotic, augmented anastomotic and onlay. Recurrence was defined as the need for intervention and diagnosed with cystoscopy or retrograde urethrogram...
July 13, 2018: Journal of Urology
Pei Han, Yong Huang, Yumin Xie, Wu Yang, Wenying Xiang, Peter J Hylands, Cristina Legido-Quigley
Introduction: In spite of advances in antibiotics, urinary tract infection (UTI) is still among the most common reasons for antibiotic medication worldwide. Persicaria capitata (Buch.-Ham. ex D. Don) H.Gross ( P. capitata ) is a herbal medicine used by the Miao people in China to treat UTI. However studies of its mechanism are challenging, owing to the complexity of P. capitata with multiple constituents acting on multiple metabolic pathways. Objective: The objective of this study was to explore the working mechanism of P...
2018: Metabolomics: Official Journal of the Metabolomic Society
Sebastiano Cimino, Paolo Verze, Luca Venturino, Paolo Alessio, Alfonso Migliara, Ciro Imbimbo, Vincenzo Mirone, Giorgio Ivan Russo, Giuseppe Morgia
BACKGROUND: Transrectal ultrasound-guided prostate biopsy (TRBx) or transperineal Bx (TPBx) are considered alternative approaches for the diagnosis of prostate cancer (PCa). However, urinary tract infection (UTI) or other complications could be more frequent in the TRBx approach. OBJECTIVE: To determine the complication rate following different antimicrobial prophylaxis (AMP; fosfomycin trometamol [FT] vs ß-lactame or fluorochinolones [FQ]) in patients undergoing TRBx or TPBx...
July 12, 2018: European Urology Focus
Niko Paalanne, Aleksi Husso, Jarmo Salo, Oskari Pieviläinen, Mysore V Tejesvi, Pirjo Koivusaari, Anna Maria Pirttilä, Tytti Pokka, Sampo Mattila, Juha Jyrkäs, Ari Turpeinen, Matti Uhari, Marjo Renko, Terhi Tapiainen
As urinary tract infection (UTI) pathogens originate from the gut, we hypothesized that the gut environment reflected by intestinal microbiome influences the risk of UTI. Our prospective case-control study compared the intestinal microbiomes of 37 children with a febrile UTI with those of 69 healthy children. We sequenced the regions of the bacterial 16S rRNA gene and used the LefSe algorithm to calculate the size of the linear discriminant analysis (LDA) effect. We measured fecal lactoferrin and iron concentrations and quantitative PCR for Escherichia coli...
July 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Melissa L Dawson, Meagan S Cramer, Dana R Thompson, Babak Vakili
Background/Aims: The rate of urinary tract infection (UTI) after pelvic reconstructive surgery ranges from 9 to 48% and the most common uropathogen is Escherichia coli ( E. coli ). The aim of the study is to identify the predominant uro-pathogen from urine cultures in women undergoing pelvic reconstructive surgery. Methods: A retrospective review was conducted on women who underwent pelvic reconstructive surgery at a tertiary care center from July 2013 to June 2015...
June 2018: Current Urology
Tessa E LeCuyer, Barbara A Byrne, Joshua B Daniels, Dubraska V Diaz-Campos, G Kenitra Hammac, Claire B Miller, Thomas E Besser, Margaret A Davis
Escherichia coli is the most common cause of human and canine urinary tract infection (UTI). Clonal groups, often with high levels of antimicrobial resistance, are a major component of the E. coli population that causes human UTI. While little is known about the population structure of E. coli that causes UTI in dogs, there is evidence that dogs and humans can share fecal strains of E.coli and that human-associated strains can cause disease in dogs. In order to better characterize the E. coli that cause canine UTI, we analyzed 295 E...
July 11, 2018: Journal of Clinical Microbiology
Justin Tenney, Nicholas Hudson, Hazar Alnifaidy, Justin Ting Cheung Li, Kathy Harriet Fung
Background: This is the first review to analyze literature identifying risk factors for a multidrug-resistant urinary tract infection (MDR UTI). Risk factors for other infections involving multidrug-resistant organisms have been evaluated in other reviews, but they do not assess urinary tract infections. The purpose of this study is to collect currently published data to determine the most commonly and consistently identified risk factors for UTIs. Material and methods: For this study, 3 independent researchers searched PubMed, Embase, and Cochrane database from 1966 to February 2016 for articles identifying risk factors for MDR UTI...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Katrina Kalantar, Sara C LaHue, Joseph L DeRisi, Hannah A Sample, Caitlin A Contag, Scott A Josephson, Michael R Wilson, Vanja C Douglas
OBJECTIVE: To identify differences in gene expression between patients with in-hospital delirium from a known etiology (urinary tract infection [UTI]) and patients with delirium from an unknown etiology, as well as from nondelirious patients. METHODS: Thirty patients with delirium (8 with UTI) and 21 nondelirious patients (11 with UTI) were included in this prospective case-control study. Transcriptomic profiles from messenger RNA sequencing of peripheral blood were analyzed for gene expression and disease-specific pathway enrichment patterns, correcting for systemic inflammatory response syndrome...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
G Shankar, Roshan M Borkar, Suresh Udutha, Suresh Pal Anagoni, R Srinivas
Balofloxacin is a fluroquinolone antibiotic drug which has been used for the treatment of urinary tract infections (UTIs). Identification and structural characterization of metabolites is a critical component of both drug discovery and drug development research. In vivo metabolites of balofloxacin have been identified and characterized by using liquid chromatography positive ion electrospray ionization high resolution tandem mass spectrometry (LC/ESI-HR-MS/MS) experiments. To identify in vivo metabolites, blood, urine and feces samples were collected after oral administration of the drug to the female Sprague-Dawley rats (n = 3 per group)...
June 28, 2018: Journal of Pharmaceutical and Biomedical Analysis
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