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Lumbar Disk Degeneration

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https://www.readbyqxmd.com/read/27879508/effect-of-an-annular-closure-device-barricaid-on-same-level-recurrent-disk-herniation-and-disk-height-loss-after-primary-lumbar-discectomy-two-year-results-of-a-multicenter-prospective-cohort-study
#1
Scott L Parker, Gordan Grahovac, Duje Vukas, Milorad Vilendecic, Darko Ledic, Matthew J McGirt, Eugene J Carragee
STUDY DESIGN: A prospective cohort study. OBJECTIVE: To evaluate whether an annular closure device could be implanted safely to reduce same-level recurrent disk herniation, or attenuate disk height loss and improve the outcome after lumbar discectomy. SUMMARY OF BACKGROUND DATA: Same-level recurrent disk herniation, disk height loss, and progressive degeneration are common complications and sequelae after lumbar discectomy. Techniques to reduce these consequences may improve outcomes...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27826214/clinical-outcome-following-diam-implantation-for-symptomatic-lumbar-internal-disk-disruption-a-3-year-retrospective-analysis
#2
Kang Lu, Po-Chou Liliang, Hao-Kuang Wang, Jui-Sheng Chen, Te-Yuan Chen, Ruyi Huang, Han-Jung Chen
BACKGROUND/OBJECTIVE: Internal disk disruption (IDD), an early event of lumbar disk degeneration, is the most common cause of low back pain. Since increased intradiskal pressure (IDP) is associated with symptoms and progression of disk degeneration, unloading a painful disk with an interspinous process device (IPD) is a rational treatment option. The goal of this study was to evaluate the effectiveness of dynamic stabilization with an IPD in the treatment of symptomatic IDD of the lumbar spine...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27807886/the-expression-of-cytokine-and-its-significance-for-the-intervertebral-disks-of-kazakhs
#3
Miao Xiaogang, Hou Quanshan, Zhang Liping, Habaxi Kaken
BACKGROUND: Proinflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 are expressed in herniated intervertebral disks of Kazakhs, but their significance is not yet understood. METHODS: Specimens of herniated lumbar disk were collected from 30 patients with single disk herniation during lumbar discectomy. As a control, 10 specimens were collected postmortem from the cadavers of individuals who did not die from spinal disease. The clinical symptoms in all cases were evaluated preoperation by the JOA index...
November 3, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27755201/radiographic-adjacent-segment-degeneration-at-5-years-after-l4-5-posterior-lumbar-interbody-fusion-with-pedicle-screw-instrumentation-evaluation-by-computed-tomography-and-annual-screening-with-magnetic-resonance-imaging
#4
Shiro Imagama, Noriaki Kawakami, Yuji Matsubara, Taichi Tsuji, Tetsuya Ohara, Yoshito Katayama, Naoki Ishiguro, Tokumi Kanemura
STUDY DESIGN: Retrospective clinical study. OBJECTIVE: To investigate adjacent segment degeneration (ASD) at 5 years after L4/5 posterior lumbar interbody fusion with pedicle screw instrumentation and L4/5 decompression surgery using plain radiographs, computed tomography (CT), and magnetic resonance imaging (MRI), with the evaluation of annual changes on MRI. SUMMARY OF BACKGROUND DATA: Methods of evaluation have been inconsistent among studies of ASD...
November 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27742516/massive-lumbar-disc-herniation-following-therapeutic-water-boiling-of-the-lower-extremities-a-case-report-and-literature-review
#5
A Spallone, M Çelniku
A 49 years-old man came to our attention with severe flaccid paraparesis occurring 10 days before, almost immediately after he had immerged his legs in boiling water for treating his severe left lombo-crural pain. This was known to be due to a right L3-L4 herniated disk diagnosed by MRI. At the examination he showed severe motor paresis and absent reflexes of his lower limbs, whilst crural pain was very mild and sensation and urinary function were unaffected. The results of his neurological examination led us to suspect an acute motor axon degeneration related to the heating shock...
October 11, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27661661/intervertebral-disc-repair-by-allogeneic-mesenchymal-bone-marrow-cells-a-randomized-controlled-trial
#6
David C Noriega, Francisco Ardura, Ruben Hernández-Ramajo, Miguel Angel Martín-Ferrero, Israel Sánchez-Lite, Borja Toribio, Mercedes Alberca, Veronica García, José Maria Moraleda, Ana Sánchez, Javier García-Sancho
BACKGROUND: Degenerative disc disease often causes severe low-back pain, a public health problem with huge economic and life quality impact. Chronic cases often require surgery, which may lead to biomechanical problems and accelerated degeneration of the adjacent segments. Autologous mesenchymal stromal cells (MSC) treatments have shown feasibility, safety and strong indications of clinical efficacy. We present here a randomized, controlled trial using allogeneic MSC, which are logistically more convenient than autologous cells...
September 21, 2016: Transplantation
https://www.readbyqxmd.com/read/27630802/a-novel-minimally-invasive-approach-to-repair-degenerative-disk-disease-in-an-ovine-model-using-injectable-polymethyl-methacrylate-and-bovine-collagen-pmma-bc
#7
Reid Hoshide, Erica Feldman, Anisha Narayan, William Taylor
BACKGROUND: The natural, inflammatory repair processes of an injured intervertebral degenerative disc can propagate further injury and destruction. While there are many different treatment modalities of the pain related to degenerative disc disease, none are actually reparative in nature. Treatment strategies to repair a degenerative disc without inducing a destructive inflammatory milieu have been elusive.  PURPOSE: The purpose of this experiment is to discover the feasibility of reconstructing an injured intervertebral disc using an injected, inert polymer as the foundation for endogenous collagen growth...
2016: Curēus
https://www.readbyqxmd.com/read/27567635/a-prospective-randomized-multicenter-phase-i-ii-clinical-trial-to-evaluate-safety-and-efficacy-of-novocart-disk-plus-autologous-disk-chondrocyte-transplantation-in-the-treatment-of-nucleotomized-and-degenerative-lumbar-disks-to-avoid-secondary-disease-safety
#8
Anja Tschugg, Michael Diepers, Steinert Simone, Felix Michnacs, Sebastian Quirbach, Martin Strowitzki, Hans Jörg Meisel, Claudius Thomé
NOVOCART(®) Disk plus, an autologous cell compound for autologous disk chondrocyte transplantation, was developed to reduce the degenerative sequel after lumbar disk surgery or to prophylactically avoid degeneration in adjacent disks, if present. The NDisc trial is an ongoing multi-center, randomized study with a sequential phase I study within the combined phase I/II trial with close monitoring of tolerability and safety. Twenty-four adult patients were randomized and treated with the investigational medicinal product NDisc plus or the carrier material only...
August 27, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27536737/rate-of-lumbar-paravertebral-muscle-fat-infiltration-versus-spinal-degeneration-in-asymptomatic-populations-an-age-aggregated-cross-sectional-simulation-study
#9
Rebecca J Crawford, Thomas Volken, Stephanie Valentin, Markus Melloh, James M Elliott
BACKGROUND: The spinal column including its vertebrae and disks has been well examined and extensively reported in relation to age-aggregated degeneration. In contrast, paravertebral muscles are poorly represented in describing normative degeneration. Increasing evidence points to the importance of paravertebral muscle quality in low back health, and their potential as a modifiable factor in low back pain (LBP). Studies examining normative decline of paravertebral muscles are needed to advance the field's etiological understanding...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27505961/-biomechanical-analysis-on-the-correlation-between-iliac-rotation-displacement-and-l-4-5-disc-degeneration
#10
Ning-ning Shi, Guo-quan Shen, Shui-yong He, Ru-bao Guo
OBJECTIVE: To study the biomechanical relationship between iliac rotation displacement and L(4,5) disc degeneration, and to provide clinical evidences for the prevention and treatment of L(4,5) disc degeneration and herniation. METHODS: From March 2012 to February 2014,68 patients with lumbar disc herniation combined with sacroiliac joint disorders were selected. Among them, 42 patients with L(4,5) disc herniation combined with sacroiliac joint disorders included 22 males and 20 females, ranging in age from 19 to 63 years old, with an average of (51...
May 2016: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/27352368/radiologic-factors-associated-with-the-dynamic-change-of-dural-sac-diameter-in-lumbar-spine-a-kinematic-mri-study
#11
Shinji Takahashi, Elizabeth L Lord, Tetsuo Hayashi, Jeremiah R Cohen, Lifeng Lao, Qingqiang Yao, Akinobu Suzuki, Hiroaki Nakamura, Jeffrey C Wang
STUDY DESIGN: This is a cross-sectional radiologic study. OBJECTIVE: The purpose of this study was to assess radiologic features related to dynamic changes of dural sac diameter using kinematic magnetic resonance imaging. SUMMARY OF BACKGROUND DATA: It is well known that the cross-sectional area of the lumbar spinal canal decreases during movement from flexion to extension. However, the radiologic characteristics related to dynamic changes of the lumbar spinal canal have not been elucidated...
June 27, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27220970/de-novo-degenerative-lumbar-scoliosis-a-systematic-review-of-prognostic-factors-for-curve-progression
#12
REVIEW
Sayf S A Faraj, Roderick M Holewijn, Miranda L van Hooff, Marinus de Kleuver, Ferran Pellisé, Tsjitske M Haanstra
PURPOSE: To identify prognostic factors for curve progression in de novo degenerative lumbar scoliosis (DNDLS) by performing a systematic review of the literature. METHODS: Studies were selected for inclusion following a systematic search in the bibliographic databases PubMed and EMBASE prior to September 2015 and hand searches of the reference lists of retrieved articles. Two authors independently assessed methodological quality. Data were extracted and presented according to a best evidence synthesis...
August 2016: European Spine Journal
https://www.readbyqxmd.com/read/27200402/neglected-alkaptonuric-patient-presenting-with-steppage-gait
#13
Babak Mirzashahi, Abbas Tafakhori, Arvin Najafi, Mahmoud Farzan
Even though intervertebral disc degeneration can be found in the natural course of alkaptonuria, detection of the disease by black disc color change in a patient without any other presentation of alkaptonuria is an exceptionally rare condition. We have reported a very rare case of alkaptonuria presented with low back pain and steppage gait in a 51-year-old male with a complaint of chronic low-back pain and steppage gait who was operated on for prolapsed lumbar disc herniation. Intraoperatively his lumbar disk was discovered to be black...
April 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27168730/diabetes-mellitus-a-new-risk-factor-for-lumbar-spinal-stenosis-a-case-control-study
#14
Leila Asadian, Kaveh Haddadi, Mohsen Aarabi, Amirhossein Zare
OBJECTIVES: This study aimed to determine the prevalence of diabetes mellitus in patients with spinal stenosis and lumbar vertebral disk degeneration, and the correlation of diabetes with these diseases. STUDY DESIGN: This is a cross-sectional study. METHODS: This case-control study was performed during 2012-2014 with 110 patients suffering from lumbar spinal stenosis and 110 patients with lumbar disk herniation, who were diagnosed using clinical and radiological evidences...
2016: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/27152925/lumbar-disc-degeneration-is-an-equally-important-risk-factor-as-lumbar-fusion-for-causing-adjacent-segment-disc-disease
#15
Raghu N Natarajan, Gunnar Bj Andersson
Treatment of degenerative spinal disorders by fusion produces abnormal mechanical conditions at mobile segments above or below the site of spinal disorders and is clinically referred to as adjacent segments disc disease (ASDD) or transition syndrome in the case of a previous surgical treatment. The aim of the current study is to understand with the help of poro-elastic finite element models how single or two level degeneration of lower lumbar levels influences motions at adjacent levels and compare the findings to motions produced by single or two level fusions when the adjacent disk has varying degree of degeneration...
May 5, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27123747/effect-of-annular-defects-on-intradiscal-pressures-in-the-lumbar-spine-an-in-vitro-biomechanical-study-of-diskectomy-and-annular-repair
#16
Richard Bostelmann, Hans-Jakob Steiger, Jan Frederick Cornelius
Background Integrity of intervertebral disks may influence, and be influenced by, the maintenance of hydrostatic pressures inside the nucleus pulposus. Disk degeneration causes decreased pressures, leading to overload and injury of the annulus fibrosus, increasing the risk of disk herniation. Diskectomies to treat disk herniation can cause further loss of hydrostatic pressures resulting in worsening degeneration. This study investigated the impact of opening the annulus on intradiscal pressure and whether implantation of an annular closure device (ACD) can restore physiologic pressures...
April 28, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27038182/clinical-and-magnetic-resonance-imaging-characteristics-of-thoracolumbar-intervertebral-disk-extrusions-and-protrusions-in-large-breed-dogs
#17
Sergio A Gomes, Holger A Volk, Rowena Ma Packer, Patrick J Kenny, Elsa Beltran, Steven De Decker
Treatment recommendations differ for dogs with intervertebral disk extrusion vs. intervertebral disk protrusion. The aim of this retrospective, cross-sectional study was to determine whether clinical and magnetic resonance imaging (MRI) variables could be used to predict a diagnosis of thoracolumbar intervertebral disk extrusion or protrusion in dogs. Dogs were included if they were large breed dogs, had an MRI study of the thoracolumbar or lumbar vertebral column, had undergone spinal surgery, and had the type of intervertebral disk herniation (intervertebral disk extrusion or protrusion) clearly stated in surgical reports...
July 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27018906/evaluation-of-water-retention-in-lumbar-intervertebral-disks-before-and-after-exercise-stress-with-t2-mapping
#18
Kou Chokan, Hideki Murakami, Hirooki Endo, Yoshikuni Mimata, Daisuke Yamabe, Itsuko Tsukimura, Ryosuke Oikawa, Minoru Doita
STUDY DESIGN: T2 mapping was used to quantify moisture content of the lumbar spinal disk nucleus pulposus (NP) and annulus fibrosus before and after exercise stress, and after rest, to evaluate the intervertebral disk function. OBJECTIVE: To clarify water retention in intervertebral disks of the lumbar vertebrae by performing magnetic resonance imaging before and after exercise stress and quantitatively measuring changes in moisture content of intervertebral disks with T2 mapping...
April 2016: Spine
https://www.readbyqxmd.com/read/26970892/objectively-quantifying-walking-ability-in-degenerative-spinal-disorder-patients-using-sensor-equipped-smart-shoes
#19
Sunghoon Ivan Lee, Eunjeong Park, Alex Huang, Bobak Mortazavi, Jordan Hayward Garst, Nima Jahanforouz, Marie Espinal, Tiffany Siero, Sophie Pollack, Marwa Afridi, Meelod Daneshvar, Saif Ghias, Daniel C Lu, Majid Sarrafzadeh
Lumbar spinal stenosis (LSS) is a condition associated with the degeneration of spinal disks in the lower back. A significant majority of the elderly population experiences LSS, and the number is expected to grow. The primary objective of medical treatment for LSS patients has focused on improving functional outcomes (e.g., walking ability) and thus, an accurate, objective, and inexpensive method to evaluate patients' functional levels is in great need. This paper aims to quantify the functional level of LSS patients by analyzing their clinical information and their walking ability from a 10 m self-paced walking test using a pair of sensorized shoes...
May 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/26871821/the-relation-between-sacral-angle-and-vertical-angle-of-sacral-curvature-and-lumbar-disc-degeneration-a-case-control-study
#20
Ahmad Ghasemi, Kaveh Haddadi, Mohammad Khoshakhlagh, Hamid Reza Ganjeh
The purpose of this study is to determine the reliability and validity of a goniometric measurement of the vertical angle of the sacrum and sacral angle (SA), and their relationships to lumbar degeneration.A herniated lumbar disc is one of the most frequent medical issues. Investigators in a number of studies have reported associated risk factors for prevalent disc degeneration. Atypical lumbosacral angles and curvature are thought to contribute to the degradation of the spine by many researchers. This study analyzed 360 patients referred to our clinic from 2013 to 2015 due to low back pain...
February 2016: Medicine (Baltimore)
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