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Cervical Degeneration

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https://www.readbyqxmd.com/read/28059798/sporadic-cases-with-novel-mutations-and-pedigree-in-hereditary-leukoencephalopathy-with-axonal-spheroids
#1
Liyong Wu, Jia Liu, Longze Sha, Xianling Wang, Jieying Li, Jing Dong, Jianping Jia
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an autosomal dominant hereditary disease, featured by cerebral white matter degeneration with demyelination and axonal spheroids. We collected three gene-confirmed HDLS cases in our neurodegenerative clinic. Two HDLS cases were sporadic with novel mutations, while another case had a family history with previously described mutations. All three cases suffered memory problems with white matter lesions and pyramid signs. No obvious clinical differences were observed between sporadic and familial HDLS cases...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28057043/rapid-healing-of-a-patient-with-dramatic-subacute-combined-degeneration-of-spinal-cord-a-case-report
#2
Florian C Roessler, Stephanie Wolff
BACKGROUND: Prevalence of cobalamin deficiency is high especially in older patients and an immediate therapy start is necessary to prevent irreversible neurological damages. Unfortunately, the diagnosis of cobalamin deficiency is difficult and at present, there is no consensus for diagnosis of this deficiency. Therefore, we aim to elucidate a meaningful diagnostic pathway by a case report with an initially misleading medical history. CASE PRESENTATION: A 57 year-old Caucasian man suffering from dramatic myelosis of the cervical posterior columns...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28056123/the-interface-of-mechanics-and-nociception-in-joint-pathophysiology-insights-from-the-facet-temporomandibular-joints
#3
Megan M Sperry, Meagan E Ita, Sonia Kartha, Sijia Zhang, Ya-Hsin Yu, Beth Winkelstein
Chronic joint pain is a widespread problem that frequently occurs with aging and trauma. Pain occurs most often in synovial joints, the body's load bearing joints. The mechanical and molecular mechanisms contributing to synovial joint pain are reviewed using two examples, the cervical spinal facet joints and temporomandibular joint. Although much work has focused on the macroscale mechanics of joints in health and disease, the combined influence of tissue mechanics, molecular processes, and nociception in joint pain has only recently become a focus...
January 5, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28042726/hybrid-cervical-disc-arthroplasty
#4
Tsung-Hsi Tu, Jau-Ching Wu, Henrich Cheng, Praveen V Mummaneni
For patients with multilevel cervical stenosis at nonadjacent segments, one of the traditional approaches has included a multilevel fusion of the abnormal segments as well as the intervening normal segment. In this video we demonstrate an alternative treatment plan with tailored use of a combination of anterior cervical discectomy and fusion (ACDF) and cervical disc arthroplasty (CDA) with an intervening skipped level. The authors present the case of a 72-year-old woman with myeloradiculopathy and a large disc herniation with facet joint degeneration at C3-4 and bulging disc at C5-6...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28033299/factors-predicting-venous-thromboembolism-after-spine-surgery
#5
Tao Wang, Si-Dong Yang, Wen-Zheng Huang, Feng-Yu Liu, Hui Wang, Wen-Yuan Ding
BACKGROUND: A meta-analysis was performed to explore predicted factors of venous thromboembolism (VTE) after surgery in the treatment for spine degeneration diseases. SUMMARY OF BACKGROUND DATA: Many scholars have focused on VTE after spine surgery, but as for the risk factors of VTE have not reached a consensus. METHODS: An extensive search of literature, "spine or spinal," "degeneration," "after surgery or postoperation," and "venous thromboembolism" as key words, was performed in PubMed/MEDLINE, Embase, the Cochrane library, CNKI, and WANFANG databases...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28032706/correlations-of-japanese-orthopaedic-association-scoring-systems-with-gait-parameters-in-patients-with-degenerative-spinal-diseases
#6
Chen-Fan Zheng, Yan-Cheng Liu, Yong-Cheng Hu, Qun Xia, Jun Miao, Ji-Dong Zhang, Kuan Zhang
OBJECTIVE: Japanese Orthopaedic Association (JOA) scoring systems were developed to evaluate the neurological function of patients with cervical or lumbar degeneration. As patient-based and multi-dimensional clinical evaluation tools, these systems should be capable of reflecting the walking disability of patients. The association between JOA scores and gait parameters, however, are not well characterized. The purpose of this study was to determine the correlations between JOA scores and gait parameters of patients with cervical spondylotic myelopathy (CSM) and lumbar intervertebral disc herniation (LDH)...
November 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28031157/evaluation-of-cervical-vestibular-evoked-myogenic-potential-findings-in-benign-paroxysmal-positional-vertigo
#7
Abdullah Karataş, Turgut Yüce, Işıl Taylan Çebi, Gülşah Acar Yüceant, Cemal Hacı, Mehti Salviz
OBJECTIVE: Although there has been a wide consensus on the mechanism of nystagmus and clinical presentation of benign paroxysmal positional vertigo (BPPV), the neuroepithelial pathophysiology of BPPV still remains unclear. In this study, we aimed to clarify the pathophysiology of BPPV by evaluating the cervical vestibular-evoked myogenic potential (cVEMP) findings of patients. MATERIALS AND METHODS: Thirty-six BPPV patients and 20 healthy volunteers were included...
December 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28002345/comparison-of-the-more-than-5-year-clinical-outcomes-of-cervical-disc-arthroplasty-versus-anterior-cervical-discectomy-and-fusion-a-protocol-for-a-systematic-review-and-meta-analysis-of-prospective-randomized-controlled-trials
#8
Min-Min Shao, Chun-Hui Chen, Zhong-Ke Lin, Xiang-Yang Wang, Qi-Shan Huang, Yong-Long Chi, Ai-Min Wu
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) was almost the "golden standard" technique in treatment of symptomatic cervical degenerative disc disease, however, it cause motion loss of the indexed level, increase the intradiscal pressure and motion of the adjacent levels, and may accelerate the degeneration of adjacent level. Cervical disc arthroplasty (CDA) was designed to preserve the motion of index level, avoid the over-activity of adjacent levels and reduce the degeneration of adjacent disc levels, the process of degeneration of adjacent level is very slowly, long term follow up studies should be conducted, this study aim to compare the more than 5 years' long-term clinical outcomes and safety between CDA and ACDF...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27995341/cervical-spine-meniscoids-an-update-on-their-morphological-characteristics-and-potential-clinical-significance
#9
REVIEW
S F Farrell, P G Osmotherly, J Cornwall, M Sterling, D A Rivett
PURPOSE: Cervical spine meniscoids are intra-articular folds of synovial membrane that have been theorised to have potential clinical significance in neck pain. Recent anatomical and clinical research has re-visited the pathoanatomical capacity of these structures. The purpose of this review is to discuss cervical spine meniscoid morphology in light of recently published work, to provide an update on the plausible relevance of these structures to clinical practice. METHODS: Narrative review critically discussing basic science and clinical research regarding cervical spine meniscoids, with focus upon implications for clinical practice...
December 19, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27974548/universal-human-papillomavirus-typing-assay-whole-genome-sequencing-following-target-enrichment
#10
Tengguo Li, Elizabeth R Unger, Dhwani Batra, Mili Sheth, Martin Steinau, Jean Jasinski, Jennifer Jones, Mangalathu S Rajeeven
We designed a universal HPV typing assay based on target enrichment and whole genome sequencing (eWGS). The RNA bait included 23,941 probes targeting 191 HPV types and 12 targeting beta-globin as control. We used Agilent SureSelect XT2 protocol for library preparation, Illumina HiSeq 2500 for sequencing and CLC genomics workbench for sequence analysis. Mapping stringency for type assignment was determined based on 8 (6 HPV-positive and 2 HPV negative) control samples. Using the optimal mapping conditions, types were assigned to 24 blinded samples...
December 14, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27965512/in-depth-analysis-on-influencing-factors-of-adjacent-segment-degeneration-after-cervical-fusion
#11
Chaojie Yu, Xiaoping Mu, Jianxun Wei, Ye Chu, Bin Liang
BACKGROUND To explore the related influencing factors of adjacent segment degeneration (ASD) after cervical discectomy and fusion (ACDF). MATERIAL AND METHODS A retrospective analysis of 263 patients who underwent ACDF was carried out. Cervical x-ray and magnetic resonance imaging (MRI) were required before operation, after operation, and at the last follow-up. General information and some radiographic parameters of all patients were measured and recorded. According to the imaging data, patients were put into one of two groups: non-ASD group and ASD group...
December 14, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27932751/-a-case-of-subacute-combined-degeneration-caused-by-vitamin-b-sub-12-sub-deficiency-in-a-cervical-spondylosis-surgery-referral
#12
Kunio Yokoyama, Masahiro Kawanishi, Akira Sugie, Makoto Yamada, Hidekazu Tanaka, Yutaka Ito, Toshihiko Kuroiwa
A 62-year-old man with a 1-year history of numbness of the extremities, clumsiness, and gait disorder was diagnosed with cervical spondylotic myelopathy at a neighboring clinic and referred to our institution for surgery. The patient had undergone a total gastrectomy 6 years previously. Flattening of the cervical cord, associated with diffuse cervical spondylosis and intramedullary intensity change, was observed on magnetic resonance imaging of the cervical spine. Neurological examination revealed decreased vibratory and position sense in all limbs, with posterior funiculus-based neurological symptoms...
December 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27916038/-mid-to-long-term-outcomes-of-cervical-disc-arthroplasty-for-symptomatic-cervical-disc-disease-a-meta-analysis
#13
S L Kan, B Yang, G Z Ning, S J Gao, J C Sun, S Q Feng
Objective: To compare the benefits and harms of cervical disc arthroplasty (CDA) with anterior cervical discectomy and fusion(ACDF) for symptomatic cervical disc disease at mid- to long-term follow-up. Methods: Electronic searches were made in PubMed, EMBASE, and the Cochrane Library for randomized controlled trials with at least 48 moths follow-up.Outcomes were reported as relative risk or standardized mean difference.Meta-analysis was carried out using Revman version 5.3 and Stata version 12.0. Results: Seven trials were included, involving 2 302 participants...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27906742/is-preexisting-cervical-disk-degeneration-a-prognostic-factor-in-whiplash-associated-disorders
#14
Nam-Su Chung, Chang-Hoon Jeon, Yu-Sang Lee, Jang-Ho Park, Han-Dong Lee
STUDY DESIGN: This is a retrospective control study. OBJECTIVE: We aimed to determine whether preexisting cervical disk degeneration is a prognostic factor in Whiplash-associated disorder (WAD). SUMMARY OF BACKGROUND DATA: WAD is a common injury of traffic accident and has a broad range of prognoses. Although numerous studies have investigated prognostic factors in WAD, few have evaluated the effect of preexisting disk degeneration. MATERIALS AND METHODS: This study involved 45 consecutive patients with grade I or II WAD having advanced disk degeneration (at least 1 disk of Miyazaki grade≥III on magnetic resonance imaging) and a control cohort of 52 patients with no or mild disk degeneration (all disks having Miyazaki grades≤II)...
November 30, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27893652/correlation-between-t2-t2-star-relaxation-time-and-cervical-intervertebral-disc-degeneration-an-observational-study
#15
Minghua Huang, Yong Guo, Qiong Ye, Lei Chen, Kai Zhou, Qingjun Wang, Lixin Shao, Qinglei Shi, Chun Chen
PURPOSE: To demonstrate the potential benefits of T2 relaxation time of intervertebral discs (IVDs) regarding the detection and grading of degenerative disc disease using 3.0-T magnetic resonance imaging (MRI) in a clinical setting. MATERIALS AND METHODS: Cervical sagittal T2-weighted, T2 relaxation MRI was performed at 3.0-T in 61 subjects, covering discs C2-3 to C6-7. All discs were morphologically assessed based on the Pfirrmann grade, and regions of interests (ROIs) were drawn over the T2 mapping...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27823929/expression-of-secreted-phosphoprotein-1-osteopontin-in-human-sensorimotor-cortex-and-spinal-cord-changes-in-patients-with-amyotrophic-lateral-sclerosis
#16
Tatsuya Yamamoto, Shigeo Murayama, Masaki Takao, Tadashi Isa, Noriyuki Higo
Secreted phosphoprotein 1 (SPP1, also known as osteopontin) is expressed in large pyramidal neurons in the primary motor cortex (M1) of certain primate species, including macaque monkeys, but not of rodents. Based on this, we suggested that SPP1 expression may reflect the functional or structural specialization of highly developed corticospinal systems. In the present study, we further characterized SPP1 in the human central nervous system by investigating its expression in the primary somatosensory cortex (S1) and spinal cord, in addition to M1...
January 15, 2017: Brain Research
https://www.readbyqxmd.com/read/27810843/evaluation-of-cervical-vestibular-evoked-myogenic-potential-findings-in-benign-paroxysmal-positional-vertigo
#17
Abdullah Karataş, Turgut Yüce, Işıl Taylan Çebi, Gülşah Acar Yüceant, Cemal Hacı, Mehti Salviz
OBJECTIVE: Although there has been a wide consensus on the mechanism of nystagmus and clinical presentation of benign paroxysmal positional vertigo (BPPV), the neuroepithelial pathophysiology of BPPV still remains unclear. In this study, we aimed to clarify the pathophysiology of BPPV by evaluating the cervical vestibular-evoked myogenic potential (cVEMP) findings of patients. MATERIALS AND METHODS: Thirty-six BPPV patients and 20 healthy volunteers were included...
August 1, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27799993/radiologic-changes-of-operated-and-adjacent-segments-after-anterior-cervical-microforaminotomy
#18
Jang Ho Ahn, Moon Sun Park, Seong Min Kim, Seung Young Chung, Do Sung Lee, Ki Seok Park
OBJECTIVE: Anterior cervical microforaminotomy (ACMF) is a motion-preserving surgical procedure. The purpose of this study is to assess radiologic changes of operated and adjacent segments after ACMF. METHODS: We retrospectively reviewed 52 patients who underwent ACMF between 1998 and 2008. From X-ray film-based changes, disc height and sagittal range of motion (ROM) of operated and adjacent segments were compared at preoperative and last follow-up periods. Radiological degeneration of both segments was analyzed as well...
September 2016: Korean Journal of Spine
https://www.readbyqxmd.com/read/27790313/age-related-incidence-of-cervical-spondylosis-in-residents-of-jeju-island
#19
Myung-Sang Moon, Min-Geun Yoon, Bong-Keun Park, Min-Suk Park
STUDY DESIGN: Cervical spine radiograms of 460 Jeju islanders. PURPOSE: To investigate the age-matched incidences and severity of the cervical disc degeneration and associated pathologic findings. OVERVIEW OF LITERATURE: Several related studies on the incidences of disc and Luschka's and facet joint degeneration have provided some basic data for clinicians. METHODS: Cervical radiographs of 460 (220 males and 240 females) patients in their fourth to ninth decade were analyzed...
October 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27781187/kinematic-magnetic-resonance-imaging-assessment-of-the-degenerative-cervical-spine-changes-after-anterior-decompression-and-cage-fusion
#20
Marina Obradov, Menno R Bénard, Michiel M A Janssen, Patricia G Anderson, Petra J C Heesterbeek, Maarten Spruit
Study Design A prospective cohort study. Objective Decompression and fusion of cervical vertebrae is a combined procedure that has a high success rate in relieving radicular symptoms and stabilizing or improving cervical myelopathy. However, fusion may lead to increased motion of the adjacent vertebrae and cervical deformity. Both have been postulated to lead to adjacent segment pathology (ASP). Kinematic magnetic resonance imaging (MRI) has been increasingly used to evaluate range of motion (ROM) of the cervical spine and ASP...
November 2016: Global Spine Journal
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