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Cervical Degeneration

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https://www.readbyqxmd.com/read/29776411/a-study-of-the-factors-associated-with-cervical-spinal-disc-degeneration-with-a-focus-on-bone-metabolism-and-amino-acids-in-the-japanese-population-a-cross-sectional-study
#1
Kanichiro Wada, Toshihiro Tanaka, Gentaro Kumagai, Hitoshi Kudo, Toru Asari, Daisuke Chiba, Seiya Ota, Keita Kamei, On Takeda, Shigeyuki Nakaji, Yasuyuki Ishibashi
BACKGROUND: The physical and biochemical factors responsible for cervical disc degeneration, and resulting in various spinal disorders, remain unclear. This study aimed to evaluate the correlation between cervical spinal canal stenosis and degeneration of intervertebral discs, and to analyze the factors related to disc degeneration in the Japanese population. METHODS: Three hundred and forty-four Japanese general residents underwent investigations, including magnetic resonance imaging of the cervical spine, in our health check project...
May 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29772854/-observation-of-early-clinical-effect-of-percutaneous-transforaminal-endoscopic-technology-in-treating-cervical-spondylotic-radiculopathy
#2
Ying-Chun Zhang, Tai-Sheng Chen, Hua Zhu
OBJECTIVE: To explore the early clinical effect and safety of percutaneous transforaminal endoscopic technology for cervical spondylotic radiculopathy. METHODS: From August 2016 to September 2017, 14 patients with cervical spondylotic radiculopathy who responded poorly to non-surgical treatment for at least 6 weeks underwent percutaneous transforaminal endoscopic discectomy via posterior approach. There were 6 males and 8 females, aging from 32 to 68 years old with an average of (40...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29762295/more-than-a-snapshot-of-the-spine-commentary-on-an-article-by-kenshi-daimon-md-et-al-a-20-year-prospective-longitudinal-study-of-degeneration-of-the-cervical-spine-in-a-volunteer-cohort-assessed-using-mri-follow-up-of-a-cross-sectional-study
#3
https://www.readbyqxmd.com/read/29762279/a-20-year-prospective-longitudinal-study-of-degeneration-of-the-cervical-spine-in-a-volunteer-cohort-assessed-using-mri-follow-up-of-a-cross-sectional-study
#4
Kenshi Daimon, Hirokazu Fujiwara, Yuji Nishiwaki, Eijiro Okada, Kenya Nojiri, Masahiko Watanabe, Hiroyuki Katoh, Kentaro Shimizu, Hiroko Ishihama, Nobuyuki Fujita, Takashi Tsuji, Masaya Nakamura, Morio Matsumoto, Kota Watanabe
BACKGROUND: Few studies have addressed in detail long-term degenerative changes in the cervical spine. In this study, we evaluated the progression of degenerative changes of the cervical spine that occurred over a 20-year period in an originally healthy cohort. We also sought to clarify the relationship between the progression of cervical degenerative changes and the development of clinical symptoms. METHODS: For this prospective follow-up investigation, we recruited 193 subjects from an original cohort of 497 participants who had undergone magnetic resonance imaging (MRI) of the cervical spine between 1993 and 1996...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29734112/a-comparison-of-a-self-locking-stand-alone-cage-and-anterior-cervical-plate-for-acdf-minimum-3-year-assessment-of-radiographic-and-clinical-outcomes
#5
Jian Zhou, Juan Li, Hong Lin, Xilei Li, Xiaogang Zhou, Jian Dong
OBJECTIVES: The self-locking stand-alone cage has been clinically applied in treating cervical degenerative disc disease (CDDD). However, no long-term clinical and radiographic studies have been performed so far. This retrospective study was designed to analyze and compare the efficacy and outcomes of anterior cervical discectomy and fusion (ACDF) using self-locking stand-alone cages and cages with the anterior cervical plating system. PATIENTS AND METHODS: A total of 98 consecutive patients were recruited in this study...
April 30, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29732581/discrete-mitochondrial-aberrations-in-the-spinal-cord-of-sporadic-als-patients
#6
Vedad Delic, Crupa Kurien, Josean Cruz, Sandra Zivkovic, Jennifer Barretta, Avery Thomson, Daniel Hennessey, Jaheem Joseph, Jared Ehrhart, Alison E Willing, Patrick Bradshaw, Svitlana Garbuzova-Davis
Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterized by progressive motor neuron degeneration in the brain and spinal cord leading to muscle atrophy, paralysis, and death. Mitochondrial dysfunction is a major contributor to motor neuron degeneration associated with ALS progression. Mitochondrial abnormalities have been determined in spinal cords of animal disease models and ALS patients. However, molecular mechanisms leading to mitochondrial dysfunction in sporadic ALS (sALS) patients remain unclear...
May 6, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29713417/clinical-relationship-of-degenerative-changes-between-the-cervical-and-lumbar-spine
#7
Yuichiro Morishita, Zorica Buser, Anthony D'Oro, Keiichiro Shiba, Jeffrey C Wang
Study Design: Retrospective, observational, case series. Purpose: To elucidate the prevalence of degenerative changes in the cervical and lumbar spine and estimate the degenerative changes in the cervical spine based on the degeneration of lumbar disc through a retrospective review of magnetic resonance (MR) images. Overview of Literature: Over 50% of middle-aged adults show evidence of spinal degeneration. However, the relationship between degenerative changes in the cervical and lumbar spine has yet to be elucidated...
April 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29702310/endoscopic-anterior-approach-for-cervical-disc-disease-disc-preserving-surgery
#8
Vijay Singh Parihar, Nishtha Yadav, Shailendra Ratre, MCh Amitesh Dubey, Yad Ram Yadav
BACKGROUND: Anterior endoscopic techniques in cervical disc were found to be effective and safe. We report our experience of 210 patients of endoscopic disc removal by anterior approach which is largest series for management of cervical myelopathy. METHODS: Visual analogue scale (VAS) and Nurick grading system was used to assess severity of neck and arm pain and functional outcomes respectively. Myelopathy (with or without unilateral or bilateral radiculopathy), or the unilateral radiculopathy having either soft or hard disc prolapsed were included...
April 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29681021/clinical-and-radiological-outcomes-of-cervical-disc-arthroplasty-ten-year-follow-up-study
#9
Qingpeng Song, Da He, Xiao Han, Ning Zhang, Jinchao Wang, Wei Tian
PURPOSE: Previous studies have demonstrated that cervical disc arthroplasty has favourable short- and medium-term clinical and radiological outcomes. However, long-term follow-up outcomes have rarely been reported. The purpose of this study was to evaluate the ten year follow-up clinical and radiological outcomes in patients who underwent Bryan cervical disc arthroplasty. METHODS: Seventy-one patients who underwent single-level Bryan cervical disc arthroplasty with a minimum ten year follow-up were included in the study...
April 21, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29680991/incidence-and-risk-factors-for-adjacent-segment-degeneration-following-occipitoaxial-fusion-for-atlantoaxial-instability-in-non-rheumatoid-arthritis
#10
Xinjie Wu, Yingna Qi, Mingsheng Tan, Ping Yi, Feng Yang, Xiangsheng Tang, Qingying Hao
PURPOSE: To investigate the incidence and risk factors for adjacent segment degeneration (ASD) following occipitoaxial fusion (OAF) for atlantoaxial instability (AAI) in non-rheumatoid arthritis (RA). METHODS: The study group comprised 41 patients without RA who underwent OAF due to AAI. Fifteen patients with postoperative ASD after OAF were classified as the ASD group, and the other 26 patients without postoperative ASD were included in the non-ASD group. There were 12 men and 3 women with a mean age of 43...
April 21, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29675672/low-virulence-bacterial-infections-in-cervical-intervertebral-discs-a-prospective-case-series
#11
Yilei Chen, Xianjun Wang, Xuyang Zhang, Hong Ren, Bao Huang, Jian Chen, Junhui Liu, Zhi Shan, Zhihai Zhu, Fengdong Zhao
STUDY DESIGN: A prospective cross-sectional case series study. OBJECTIVE: To investigate the prevalence of low virulence disc infection and its associations with characteristics of patients or discs in the cervical spine. BACKGROUND: Low virulence bacterial infections could be a possible cause of intervertebral disc degeneration and/or back pain. Controversies are continuing over whether these bacteria, predominantly Propionibacterium acnes (P...
April 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29673307/the-pathology-of-wobbly-hedgehog-syndrome
#12
Josué Díaz-Delgado, Derick B Whitley, Ralph W Storts, Jill J Heatley, Sharman Hoppes, Brian F Porter
Wobbly hedgehog syndrome (WHS) is a leading cause of neurologic disease in African pygmy hedgehogs (APHs; Atelerix albiventris). This study describes the signalment, clinical signs, gross, microscopic, and ultrastructural lesions of WHS in a cohort of 12 pet APHs. Microscopically, lesions consisted of status spongiosus of the white matter, typically bilateral and symmetrical, with myelin degeneration and loss that was accompanied by neuronal/axonal degeneration plus reactive microgliosis and mild, focal astrocytosis and astrogliosis...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29671017/-degenerative-cervical-spine-diseases-fusion-vs-total-disc-replacement-what-can-be-done-when
#13
REVIEW
T Pitzen, J Drumm, C Berthold, G Ostrowski, U Heiler, M Ruf
Motion preserving surgery within the cervical spine may be performed by special implants, for example, c spine disc prosthesis or total disc replacement (cTDR), or by simple decompression of the cervical nerve roots. However, also fusion surgery may be performed with good results. Here, we summarize indications as well as contraindications for motion preserving techniques and indications for fusion surgery. cTDR is indicated in special cases of soft disc herniation, especially in younger individuals without signs of myelopathy...
April 18, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29670903/apparent-diffusion-coefficient-of-diffusion-weighted-imaging-in-evaluation-of-cervical-intervertebral-disc-degeneration-an-observational-study-with-3-0-t-magnetic-resonance-imaging
#14
Pinjie Chen, Chunlei Wu, Minghua Huang, Guangjian Jin, Qinglei Shi, Zhihua Han, Chun Chen
Aims: To investigate the correlation between the apparent diffusion coefficient (ADC) value and cervical intervertebral disc degeneration in adult symptomatic patients. Methods: A total of 52 symptomatic and 40 healthy volunteers were included. DWI and routine MRI examinations were performed to their cervical spines. The cervical discs (from C2-C3 to C6-C7) were graded according to the Pfirrmann grading system, and ADC values of the nucleus pulposus (NP) were measured...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29669576/modic-changes-in-the-cervical-endplate-of-patients-suffering-from-cervical-spondylotic-myelopathy
#15
Pan Qiao, Tian-Tong Xu, Wen Zhang, Rong Tian
BACKGROUND: The distribution and related factors of Modic changes (MC) in the lumbar spine has been evaluated. In the present study, the MC in the cervical endplate of patients with cervical spondylotic myelopathy (CSM) was investigated. METHODS: A total of 6422 cervical endplates of 539 patients suffered from CSM (259 males and 280 females) with mean age of 46 ± 5.2 years. All patients underwent MRI scans and X-ray for evaluating the distribution of MC. The clinical information were recorded...
April 18, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29665815/a-comparison-of-zero-profile-anchored-spacer-roi-c-and-plate-fixation-in-2-level-noncontiguous-anterior-cervical-discectomy-and-fusion-a-retrospective-study
#16
Zongyu Zhang, Yawei Li, Weimin Jiang
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) is the classic surgical treatment for symptomatic cervical degenerative disc disease (CDDD). However, there is controversy over the best surgical management in patients with two noncontiguous symptomatic levels of CDDD. METHODS: From April 2011 to May 2014, 44 patients with two noncontiguous symptomatic levels of CDDD underwent skip-level ACDFs. In Group NoPlate, 23 cases underwent 2 noncontiguous levels of ACDF using zero-profile anchored spacer; and in Group Plate, 21 cases underwent 2 noncontiguous levels of ACDF using cages and plates...
April 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29649666/a-retrospective-study-does-cigarette-smoking-induce-cervical-disc-degeneration
#17
Zhaoxiong Chen, Xinhua Li, Fumin Pan, Desheng Wu, Haoxi Li
OBJECTIVE: To investigate cigarette smoking's relevance with cervical disc degeneration. METHODS: We randomly selected 320 patients who came to our spine disease department outpatient clinic with chief complaint of neck-shoulder pain during June 2014-June 2016. According to the detailed smoking history, these patients were divided into 3 different groups, which were active smoker group (AS), passive smoking group (PS) and never-smoker group (NS). Each patient's Miyazaki's magnetic resonance imaging (MRI) classification of cervical disc degeneration was analyzed based on their cervical MRI films...
April 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29629793/3d-ultrashort-te-mri-for-evaluation-of-cartilaginous-endplate-of-cervical-disk-in-vivo-feasibility-and-correlation-with-disk-degeneration-in-t2-weighted-spin-echo-sequence
#18
Yeo Ju Kim, Jang Gyu Cha, Yoon Sang Shin, Akshay S Chaudhari, Young Ju Suh, Seung Hwan Yoon, Garry E Gold
OBJECTIVE: The purpose of this study was to evaluate the feasibility of 3D ultrashort TE (UTE) MRI in depicting the cartilaginous endplate (CEP) and its abnormalities and to investigate the association between CEP abnormalities and disk degeneration on T2-weighted spin-echo (SE) MR images in cervical disks in vivo. SUBJECTS AND METHODS: Eight healthy volunteers and 70 patients were examined using 3-T MRI with the 3D UTE cones trajectory technique (TR/TE, 16.1/0...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29629185/evaluation-of-spine-mris-in-athletes-participating-in-the-rio-de-janeiro-2016-summer-olympic-games
#19
Michael S Wasserman, Ali Guermazi, Mohamed Jarraya, Lars Engbretsen, Mohamad AbdelKader, Frank W Roemer, Daichi Hayashi, Michel D Crema, Asim Z Mian
Background/aim: In high-level Olympic athletes, many spinal pathologies arise from overuse, while others are the result of acute injury. Our aim is to analyse the epidemiology of spinal pathologies detected on MRI in athletes participating in the 2016 Rio de Janeiro Summer Olympics. Methods: In this retrospective study, all spine MRIs performed during the 2016 Rio Games were analysed. Descriptive data from the MRIs were tabulated and analysed for disc degeneration, spinal canal and/or neural foraminal narrowing, and acute/chronic fractures...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29618341/quantitative-analysis-of-near-implant-magnesium-accumulation-for-a-si-containing-coated-az31-cage-from-a-goat-cervical-spine-fusion-model
#20
Fan Zhang, Haocheng Xu, Hongli Wang, Fang Geng, Xiaosheng Ma, Minghao Shao, Shun Xu, Feizhou Lu, Jianyuan Jiang
BACKGROUND: Magnesium (Mg) released from Mg-based implants degradation is believed to be effective in improving osteogenesis, however, studies focusing on Mg-based interbody cages are limited and fusion success was never reported. As excessive Mg accumulation can inhibit new bone formation, this study is designed to explain the possible reasons for the fusion failure of Mg-based cages by analyzing the relationships between the intervertebral Mg accumulation and the resulting interbody fusion...
April 4, 2018: BMC Musculoskeletal Disorders
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