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Cervical Degeneration

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https://www.readbyqxmd.com/read/28625479/the-change-of-adjacent-segment-after-cervical-disc-arthroplasty-compared-with-anterior-cervical-discectomy-and-fusion-a-meta-analysis-of-randomized-controlled-trials
#1
REVIEW
Liang Dong, Zhengwei Xu, Xiujin Chen, Dongqi Wang, Dichen Li, Tuanjing Liu, Dingjun Hao
BACKGROUD CONTEXT: Many meta-analyses have been performed to study the efficacy of cervical disc arthroplasty (CDA) compared with anterior cervical discectomy and fusion (ACDF); however, there are few data referring to adjacent segment within these meta-analyses, or investigators are unable to arrive at the same conclusion in the few meta-analyses about adjacent segment. With the increased concerns surrounding adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDis) after anterior cervical surgery, it is necessary to perform a comprehensive meta-analysis to analyze adjacent segment parameters...
June 15, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28622494/laryngeal-neuropathy-in-adult-goats-with-copper-deficiency
#2
R F A Sousa, V M Almeida, J E Neto, C W A Nascimento, G X Medeiros, R M T Medeiros, F Riet-Correa, F S Mendonça
The aim of this study was to elucidate the cause of a neurological syndrome characterized by stridor in adult goats with clinical signs of copper deficiency. The main clinical signs consisted of apathy, emaciation, pale mucous membranes, mucous nasal discharge, dyspnea, severe achromotrichia, diffuse alopecia, torpor, ataxia, and stridor. When the goats were forced to move, the stridor increased. In a herd of 194 Toggenburg goats, 10 adult goats with clinical signs of copper deficiency were removed from the herd and divided into 2 groups: group 1, which consisted of 4 nannies and 1 buck with stridor, and group 2, which consisted of 4 nannies and 1 buck without stridor...
July 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28622185/a-comprehensive-meta-analysis-of-the-adjacent-segment-parameters-in-cervical-disk-arthroplasty-versus-anterior-cervical-discectomy-and-fusion
#3
Liang Dong, Dongqi Wang, Xiujin Chen, Tuanjing Liu, Zhengwei Xu, Mingsheng Tan, Dingjun Hao
STUDY DESIGN: This is a meta-analysis of controlled trials. OBJECTIVE: To assess the overall condition of adjacent segment of cervical disk arthroplasty (CDA) compared with anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: With the increase in CDA and ACDF, surgeons are taking more attention to adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDis). There are more and more meta-analyses comparing the efficacy of CDA with ACDF, however, there are few meta-analyses referring to adjacent segment parameters, and investigators are still unable to arrive at the same conclusion...
June 15, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28606605/cervical-and-thoracic-intervertebral-disc-hydration-increases-with-recumbency-a-study-in-101-healthy-volunteers
#4
Daniel L Belavy, Matthew Quittner, Yuan Ling, David Connell, Timo Rantalainen
BACKGROUND CONTEXT: Variation in water content and size of the lumbar intervertebral discs (IVDs) is known to occur due to recumbency and has been associated with lumbar IVD herniation risk through the impact of IVD hydration on tissue mechanical properties. It is not clear if similar changes in the cervical or thoracic IVDs occur with recumbency. PURPOSE: Determine whether increases in hydration of thoracic and cervical IVDs occur with short-duration recumbency...
June 9, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28604508/symptomatic-adjacent-segment-disease-after-anterior-cervical-discectomy-for-single-level-degenerative-disk-disease
#5
Roland D Donk, Wim I M Verhagen, Allard J F Hosman, Andre Verbeek, Ronald H M A Bartels
STUDY DESIGN: A prospective cohort of 142 patients underwent either anterior cervical discectomy alone, anterior cervical discectomy with fusion by cage stand-alone, or anterior cervical discectomy with arthroplasty. We then followed up on their condition for a mean of 9.1±1.9 years (5.6-12.2 y) later. OBJECTIVE: We aimed to evaluate the annual rate of clinically symptomatic adjacent segment disease (ASD) and to analyze predictive factors. SUMMARY OF BACKGROUND DATA: Until recent, ASD has been predominantly evaluated radiologically...
June 9, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28604488/anterior-cervical-discectomy-and-fusion-outcomes-over-10-years-a-prospective-study
#6
Glenn R Buttermann
STUDY DESIGN: Prospective cohort study with >10-year follow-up. OBJECTIVE: To assess the long-term, >10-year, clinical outcomes of anterior cervical discectomy and fusion (ACDF) and to compare outcomes based on primary diagnosis of disc herniation; stenosis or advanced degenerative disc disease (DDD); number of levels treated; and preexisting adjacent level degeneration. SUMMARY OF BACKGROUND DATA: ACDF is a proven treatment for patients with stenosis and disc herniation and results in significantly improved short- and intermediate-term outcomes...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28603486/comparison-of-sirtuin-3-levels-in-als-and-huntington-s-disease-differential-effects-in-human-tissue-samples-vs-transgenic-mouse-models
#7
Eva Buck, Hanna Bayer, Katrin S Lindenberg, Johannes Hanselmann, Noemi Pasquarelli, Albert C Ludolph, Patrick Weydt, Anke Witting
Neurodegenerative diseases are characterized by distinct patterns of neuronal loss. In amyotrophic lateral sclerosis (ALS) upper and lower motoneurons degenerate whereas in Huntington's disease (HD) medium spiny neurons in the striatum are preferentially affected. Despite these differences the pathophysiological mechanisms and risk factors are remarkably similar. In addition, non-neuronal features, such as weight loss implicate a dysregulation in energy metabolism. Mammalian sirtuins, especially the mitochondrial NAD+ dependent sirtuin 3 (SIRT3), regulate mitochondrial function and aging processes...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28597366/finite-element-model-predicts-the-biomechanical-performance-of-cervical-disc-replacement-and-fusion-hybrid-surgery-with-various-geometry-of-ball-and-socket-artificial-disc
#8
Yang Li, Guy R Fogel, Zhenhua Liao, Weiqiang Liu
PURPOSE: Few finite element studies have investigated changes in cervical biomechanics with various prosthesis design parameters using hybrid surgery (HS), and none have investigated those combined different HS strategies. The aim of our study was to investigate the effect of ball-and-socket prosthesis geometry on the biomechanical performance of the cervical spine combined with two HS constructs. METHODS: Two HS strategies were conducted: (1) ACDF at C4-C5 and anterior cervical disc replacement (ACDR) at C5-C6 (ACDF/ACDR), and (2) ACDR/ACDF...
June 8, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28597208/subject-specific-regional-measures-of-water-diffusion-are-associated-with-impairment-in-chronic-spinal-cord-injury
#9
Ann S Choe, Cristina L Sadowsky, Seth A Smith, Peter C M van Zijl, James J Pekar, Visar Belegu
PURPOSE: We aimed to identify non-invasive imaging parameters that can serve as biomarkers for the integrity of the spinal cord, which is paramount to neurological function. Diffusion tensor imaging (DTI) indices are sensitive to axonal and myelin damage, and have strong potential to serve as such biomarkers. However, averaging DTI indices over large regions of interest (ROIs), a common approach to analyzing the images of injured spinal cord, leads to loss of subject-specific information...
June 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28591781/global-spinal-alignment-in-cervical-kyphotic-deformity-the-importance-of-head-position-and-thoracolumbar-alignment-in-the-compensatory-mechanism
#10
Jun Mizutani, Kushagra Verma, Kenji Endo, Ken Ishii, Kuniyoshi Abumi, Mitsuru Yagi, Naobumi Hosogane, Jeffrey Yang, Bobby Tay, Vedat Deviren, Christopher Ames
BACKGROUND: Previous studies have evaluated cervical kyphosis (C-kypho) using cervical curvature or chin-brow vertical angle, but the relationship between C-kypho and global spinal alignment is currently unknown. OBJECTIVE: To elucidate global spinal alignment and compensatory mechanisms in primary symptomatic C-kypho using full-spine radiography. METHODS: In this retrospective multicenter study, symptomatic primary C-kypho patients (Cerv group; n = 103) and adult thoracolumbar deformity patients (TL group; n = 119) were compared...
June 7, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28591077/progressive-bone-formation-after-cervical-disc-replacement-minimum-of-5-year-follow-up
#11
Feifei Zhou, Kevin L Ju, Yanbin Zhao, Fengshan Zhang, Shengfa Pan, John G Heller, Yu Sun
OBJECTIVE: Our objective was to examine the prevalence, clinical significance, ramifications, and possible etiology of postoperative bone formation at the index level after Cervical Disc Replacement (CDR) with a minimum of five years of follow-up. SUMMARY OF BACKGROUND DATA: CDR can be complicated by postoperative ossification and unwanted ankylosis at the index level, which some authors have termed "heterotopic ossification". This terminology may be inaccurate as it assumes the postoperative bone formation is unnatural and a consequence of the CDR surgery...
June 6, 2017: Spine
https://www.readbyqxmd.com/read/28584675/musculoskeletal-neck-pain-in-children-and-adolescents-risk-factors-and-complications
#12
Jawad Fares, Mohamad Y Fares, Youssef Fares
BACKGROUND: Neck pain is a major public health concern that has been extensively studied in adults but not in children and adolescents. Therefore, the purpose of this article is to explore musculoskeletal neck pain in children and adolescents, as well as to discuss its possible risk factors and complications. METHODS: Participants were patients under 18 years of age, who had presented to the clinic (Beirut, Lebanon) in 2015, with nonspecific neck pain. They were examined and asked to evaluate and localize the pain...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28575461/adjacent-segment-degeneration-after-anterior-cervical-discectomy-and-fusion-with-an-autologous-iliac-crest-graft-a-magnetic-resonance-imaging-study-of-59-patients-with-a-mean-follow-up-of-27%C3%A2-yr
#13
Benedikt W Burkhardt, Andreas Simgen, Gudrun Wagenpfeil, Wolfgang Reith, Joachim M Oertel
BACKGROUND: Anterior cervical decompression and fusion (ACDF) is a widely accepted surgical technique for the treatment of degenerative disc disease. ACDF is associated with adjacent segment degeneration (ASD). OBJECTIVE: To assess whether physiological aging of the spine would overcome ASD by comparing adjacent to adjoining segments more than 18 yr after ACDF. METHODS: Magnetic resonance imaging of 59 (36 male, 23 female) patients who underwent ACDF was performed to assess degeneration...
May 30, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28574978/adjacent-segment-degeneration-following-anterior-cervical-discectomy-and-fusion-versus-the-bryan-cervical-disc-arthroplasty
#14
Suo-Zhou Yan, Jun Di, Yong Shen
BACKGROUND Anterior cervical discectomy and fusion (ACDF) is an established treatment for degenerative disease of the cervical disc, but adjacent segment degeneration or instability may develop long term. The aim of this study was to investigate the risk factors for adjacent segment degeneration following ACDF compared with the use of the Bryan artificial disc for cervical disc arthroplasty (CDA). MATERIAL AND METHODS A prospective comparative study included 93 patients who underwent ACDF or CDA with the Bryan artificial cervical disc between 2002 and 2004, and who had more than eight years of follow-up...
June 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28559077/incidence-and-risk-factors-of-postoperative-adjacent-segment-degeneration-following-anterior-decompression-and-instrumented-fusion-for-degenerative-disorders-of-the-cervical-spine
#15
Hui Wang, Lei Ma, Dalong Yang, Sidong Yang, Wenyuan Ding
INTRODUCTION: The aim of this study was to explore the incidence and risk factors of postoperative adjacent segment degeneration following anterior decompression and instrumented fusion for degenerative disorders of the cervical spine, and hope to provide references in decision making and surgical planning for spinal surgeons. METHODS: By retrieving the medical records from January 2005 to September 2011, 283 patients were retrospectively reviewed. According to the occurrence of adjacent segment degeneration at follow up, patients were divided into two groups: ASD group and no ASD group...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28525482/artificial-cervical-disk-replacement-for-the-treatment-of-adjacent-segment-disease-after-anterior-cervical-decompression-and-fusion
#16
Sheng Bin, Huang Xiangwang, Xiao Sheng, Xiang Tiecheng, Liu Xiangyang, Zhang Yi, Liu Bin
STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the outcome of artificial cervical disk replacement (ACDR) for the treatment of adjacent segment disease (ASD) after anterior cervical decompression and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is the useful procedure for degenerative cervical diseases. However, studies have reported accelerated degeneration of functional spinal units adjacent to the fusion site after ACDF. MATERIALS AND METHODS: Between January 2004 and January 2011, 32 inpatients (18 male, 14 female; age, 38-61 y; mean, 48 y) underwent ACDR for the treatment of ASD after previous ACDF (single-level: n=12; 2-level: n=15; 3-level: n=5)...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525481/comparison-of-the-clinical-and-radiographic-results-between-cervical-artificial-disk-replacement-and-anterior-cervical-fusion-a-6-year-prospective-nonrandomized-comparative-study
#17
Wei Tian, Kai Yan, Xiao Han, Jie Yu, Peihao Jin, Xiaoguang Han
STUDY DESIGN: Prospective nonrandomized comparative study. OBJECTIVE: To compare the long-term clinical and radiographic results of cervical artificial disk replacement (CADR) and anterior cervical discectomy and fusion (ACDF), and to provide our evidence if CADR could reduce adjacent segment degeneration (ASD). SUMMARY OF BACKGROUND DATA: CADR is widely used in spine surgery today. Despite the short-term results of it having been ascertained, the long-term results are still under observation...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525476/magnetic-resonance-classification-system-of-cervical-intervertebral-disk-degeneration-its-validity-and-meaning
#18
Akinobu Suzuki, Michael D Daubs, Tetsuo Hayashi, Monchai Ruangchainikom, Chenjie Xiong, Kevin Phan, Trevor P Scott, Jeffery C Wang
STUDY DESIGN: Retrospective analysis of kinetic magnetic resonance images (kMRIs). OBJECTIVE: (1) To analyze the changes seen on MRI related to disk degeneration and to develop a new grading system for cervical disk degeneration. (2) To evaluate the reliability and validity of the grading system. SUMMARY OF BACKGROUND DATA: Few have studied the relationship between changes seen on MRI with cervical disk degeneration and the chronological order of disk degeneration...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28511972/a-matched-cohort-comparison-of-cervical-disc-arthroplasty-versus-anterior-cervical-discectomy-and-fusion-evaluating-perioperative-outcomes
#19
Pavan S Upadhyayula, John K Yue, Erik I Curtis, Reid Hoshide, Joseph D Ciacci
OBJECTIVE: Cervical disc arthroplasty (CDA) is a recent alternative to anterior cervical discectomy and fusion (ACDF) in patients suffering cervical disc herniation and degeneration. To date, a systematic analysis of their comparative advantages and risks following elective surgery remains elusive. METHODS: Adult patients undergoing elective CDA or ACDF were extracted from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database years 2011-2014...
May 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28506346/-role-of-short-latency-somatosensory-evoked-potential-in-the-diagnosis-of-chronic-inflammatory-demyelinating-polyneuropathy
#20
Rui-Di Sun, Bing Fu, Jun Jiang
OBJECTIVE: To investigate the role of short-latency somatosensory evoked potential (SSEP) in the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: A total of 48 children with a confirmed or suspected CIDP and 40 healthy children were enrolled. Nerve electrophysiological examination and/or SSEP examination was performed (the children in the healthy control group only underwent SSEP examination). Four-lead electromyography was used for nerve electrophysiological examination, including at least 4 motor nerves and 2 sensory nerves...
May 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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