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Low Testosterone Treatment In Males

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https://www.readbyqxmd.com/read/29207507/zinc-ameliorate-oxidative-stress-and-hormonal-disturbance-induced-by-methomyl-abamectin-and-their-mixture-in-male-rats
#1
Sameeh A Mansour, Mostafa A Abbassy, Hassan A Shaldam
Exposure to mixtures of toxicants (e.g., pesticides) is common in real life and a subject of current concern. The present investigation was undertaken to assess some toxicological effects in male rats following exposure to methomyl (MET), abamectin (ABM), and their combination (MET+ABM), and to evaluate the ameliorative effect of zinc co-administration. Three groups of rats were designated for MET, ABM, and the mixture treatments. Three other groups were designated for zinc in conjunction with the pesticides...
December 3, 2017: Toxics
https://www.readbyqxmd.com/read/29195019/is-immunosuppression-induced-by-neonatal-thymectomy-compatible-with-poor-reproductive-performance-in-adult-male-rats
#2
M M Ommati, N Tanideh, B Rezakhaniha, J Wang, S Sabouri, M Vahedi, B Dormanesh, O Koohi Hosseinabadi, F Rahmanifar, S Moosapour, A Akhlaghi, R Heidari, M J Zamiri
With increasing knowledge that the immune system has a major impact on reproductive ‎health, the potential for cells arising in organs such as the thymus to alleviate oxidative stress ‎has been revealed. This study addresses the impact of neonatal thymectomy on male ‎reproductive function in pubertal and adult animals. Neonatal Sprague Dawley rats were allotted to four treatments consisting of fully thymectomized, partially thymectomized, intact, and sham-operated rats. Half of the rats in each treatment were sacrificed at 40 and the other half at 80 days of age...
December 1, 2017: Andrology
https://www.readbyqxmd.com/read/29190387/chronic-hyperandrogenemia-in-the-presence-and-absence-of-a-western-style-diet-impairs-ovarian-and-uterine-structure-function-in-young-adult-rhesus-monkeys
#3
Cecily V Bishop, Emily C Mishler, Diana L Takahashi, Taylor E Reiter, Kise R Bond, Cadence A True, Ov D Slayden, Richard L Stouffer
STUDY QUESTION: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys? SUMMARY ANSWER: Phenotypic alterations in ovarian and uterine structure/function were induced by exogenous testosterone (T), and compounded in the presence of a WSD (T+WSD). WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of PCOS and is observed in adolescent girls, indicating a potential pubertal onset of disease symptoms...
November 28, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29184488/brain-maturation-cognition-and-voice-pattern-in-a-gender-dysphoria-case-under-pubertal-suppression
#4
Maiko A Schneider, Poli M Spritzer, Bianca Machado Borba Soll, Anna M V Fontanari, Marina Carneiro, Fernanda Tovar-Moll, Angelo B Costa, Dhiordan C da Silva, Karine Schwarz, Maurício Anes, Silza Tramontina, Maria I R Lobato
Introduction: Gender dysphoria (GD) (DMS-5) is a condition marked by increasing psychological suffering that accompanies the incongruence between one's experienced or expressed gender and one's assigned gender. Manifestation of GD can be seen early on during childhood and adolescence. During this period, the development of undesirable sexual characteristics marks an acute suffering of being opposite to the sex of birth. Pubertal suppression with gonadotropin releasing hormone analogs (GnRHa) has been proposed for these individuals as a reversible treatment for postponing the pubertal development and attenuating psychological suffering...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29183245/variation-in-practice-pattern-of-male-hypogonadism-a-comparative-analysis-of-primary-care-urology-endocrinology-and-hiv-specialists
#5
Yash S Khandwala, Omer A Raheem, Mir Amaan Ali, Tung-Chin Hsieh
The objective of the current study was to measure the adherence of guideline-based evaluation and treatment of hypogonadism by medical specialty. A retrospective review was performed analyzing patients from a single academic institution within the past 10 years. The cohort of 193 men was grouped according to medical specialty of the diagnosing physician (50 urology, 49 primary care, 44 endocrinology, and 50 HIV medicine). Adherence to guidelines was assessed using the Endocrine Society's criteria. Primary care patients were older compared to the rest of the cohort ( p < ...
November 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29159543/endosulfan-is-toxic-to-the-reproductive-health-of-male-freshwater-fish-cyprinion-watsoni
#6
Fakhar Ul Islam, Samina Jalali, Mustafa Nawaz Shafqat, Syed Tahir Abbas Shah
Endosulfan is an organochlorine pesticide that is toxic to aquatic life. Endosulfan might hamper the reproductive health of indigenous fish in agricultural areas of Pakistan where this pesticide is sprayed widely. The aim of the current study is to investigate the toxic effects of endosulfan on selected reproductive parameters of male freshwater fish, Cyprinion watsoni. Two concentrations of endosulfan (0.5 and 1 ppb for 30 days exposure) were tested for their effects on body weight, body length, and testicular weight, length, and width...
November 20, 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/29159311/the-response-of-the-menstrual-cycle-to-initiation-of-hormonal-therapy-in-transgender-men
#7
Shazia Ahmad, Matthew Leinung
Purpose: Transition from female to male gender after initiation of hormonal therapy involves both phenotypic and physiological changes. The response to treatment can vary widely from person to person. In this study, we looked at the response of the menstrual cycle after the initiation of testosterone therapy and we wished to determine the time period and dose of testosterone leading to the cessation of menses in transgender men. Methods: A retrospective chart review of 114 transgender men (individuals assigned female gender at birth but later identify themselves as males) seen for hormonal therapy in our transgender clinic from 2006 through 2016...
2017: Transgender Health
https://www.readbyqxmd.com/read/29134985/effects-of-unripe-musa-paradisiaca-on-the-histochemistry-of-the-testis-and-testosterone-levels-in-adult-albino-rats
#8
A S Alabi, G O Omotosho, C N B Tagoe, O B Akinola, B U Enaibe
This study was aimed at determining the effects of the unripe fruit of Musa paradisiaca on the testis andtestosterone levels in male Wistar rats. The animals were grouped into three, comprising a control, and 2 treatment groupsadministered with different doses (500 mg/kg and 1000 mg/kg) daily of the fruit flour over 28 days. Histochemical evaluationof the testes was done using Haematoxylin and Eosin, Periodic acid Schiff's (PAS) and Feulgen staining techniques, whilethe serum and homogenised testicular tissue were evaluated for testosterone levels using Accu-Bind ELISA Kit...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29128270/low-serum-testosterone-in-outpatient-psychiatry-clinics-addressing-challenges-to-the-screening-and-treatment-of-hypogonadism
#9
REVIEW
Justin B Smith, Jordan Rosen, Adam Colbert
INTRODUCTION: The symptoms of low testosterone frequently overlap with psychiatric complaints including depression and fatigue. Testosterone repletion has been shown to improve mood symptoms in men with low testosterone, although this finding has not been consistent across all studies. Despite the potential importance of low testosterone for psychiatry, the prevalence of low testosterone in men who present to psychiatric clinics with mental health complaints is unknown. AIM: To provide an overview of the current state of knowledge of the psychiatric complications of male hypogonadism, the challenges of screening for hypogonadism in a psychiatric population, and the potential mental health treatment implications of hypogonadism...
November 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29106989/gonadal-hormones-affect-alcohol-drinking-but-not-cue-yohimbine-induced-alcohol-seeking-in-male-and-female-rats
#10
Megan L Bertholomey, Mary M Torregrossa
Alcohol use disorder (AUD) is a chronic, relapsing disease characterized by maladaptive patterns of alcohol drinking and seeking. Though sex differences exist in the etiology of AUD, much remains to be elucidated concerning the mechanisms underlying sex-related vulnerability to developing excessive alcohol-motivated behavior. While a large body of evidence points to an important role of circulating gonadal hormones in mediating cocaine reinforcement, findings are less consistent with respect to ethanol. Critically, the effects of gonadal hormones on the reinstatement of ethanol seeking, a model of "craving"-like behavior that reveals pronounced sex differences, has not yet been examined...
October 26, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29095270/pituitary-insufficiency-following-traumatic-thoracic-injury-in-an-adolescent-male-patient-a-case-report-and-literature-review
#11
REVIEW
Aleksandra Gilis-Januszewska, Łukasz Kluczyński, Małgorzata Wilusz, Jacek Pantofliński, Renata Turek-Jabrocka, Dorota Pach, Alicja Hubalewska-Dydejczyk
RATIONALE: Traumatic thoracic injuries in adolescents are rare but could be connected with traumatic brain injuries (TBI) and development of chronic hypopituitarism. Early recognition of these endocrine problems is a significant challenge to clinicians. We present difficulties in diagnosis of hypothalamic-pituitary insufficiency following traumatic thoracic injury in adolescence. We also review the literature of similar cases. PATIENT CONCERNS: We present a case of a 24-years-old male...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29075189/a-short-term-exposure-to-tributyltin-blocks-leydig-cell-regeneration-in-the-adult-rat-testis
#12
Xiaolong Wu, Jianpeng Liu, Yue Duan, Shiyu Gao, Yao Lü, Xiaoheng Li, Qiqi Zhu, Xianwu Chen, Jing Lin, Leping Ye, Ren-Shan Ge
Background: Tributyltin (TBT) is widely used as an antifouling agent that may cause reproductive toxicity. The mechanism of TBT on Leydig cell development is still unknown. The objective of the present study was to investigate whether a brief exposure to low doses of TBT permanently affects Leydig cell development and to clarify the underlying mechanism. Methods: Adult male Sprague Dawley rats were randomly assigned into four groups and gavaged normal saline (control), 0.1, 1.0, or 10.0 mg/kg/day TBT for a consecutive 10 days, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29029242/germ-cell-neoplasia-in-situ-and-preserved-fertility-despite-suppressed-gonadotropins-in-a-patient-with-testotoxicosis
#13
Li Juel Mortensen, Martin Blomberg Jensen, Peter Christiansen, Ann-Margrethe Rønholt, Anne Jørgensen, Hanne Frederiksen, John E Nielsen, Anand C Loya, Birgitte Grønkær Toft, Niels E Skakkebæk, Ewa Rajpert-De Meyts, Anders Juul
Context: Testotoxicosis is an autosomal dominant, male-limited disorder. Activating mutations in the Luteinizing Hormone Receptor gene (LHCGR) cause high autonomous testosterone secretion resulting in early-onset peripheral precocious puberty. Little is known about long-term consequences of testotoxicosis. Case Description: We present a rare case of a patient followed for 25 years with two remarkable outcomes; preserved fertility and germ cell neoplasia in situ (GCNIS)...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028483/circulating-levels-of-sgp130-and-sex-hormones-in-male-patients-with-coronary-atherosclerotic-disease
#14
Yan Cui, Wen Dai, Yan Li
BACKGROUND AND AIMS: Inflammation and endocrine disorders are considered as major pathogenic factors of coronary atherosclerotic disease (CAD). Sgp130, a natural antagonist of IL-6 trans-signaling, and sex hormones, especially testosterone and estradiol, are prominently considered as anti-atherosclerotic. The aim of this study was to investigate the possible association between serum sgp130 and testosterone and estradiol in male CAD patients. METHODS: A total of 254 male patients with CAD and 122 male controls were recruited for this study...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28973382/ziram-delays-pubertal-development-of-rat-leydig-cells
#15
Xiaoling Guo, Songyi Zhou, Yong Chen, Xianwu Chen, Jianpeng Liu, Fei Ge, Qingquan Lian, Xiaomin Chen, Ren-Shan Ge
Ziram [zinc, bis (dimethyldithiocarbamate)] is an agricultural dithiocarbamate fungicide. By virtual screening, we have identified that ziram is a potential endocrine disruptor. To investigate its effects on pubertal development of Leydig cells, 35-day-old male Sprague Dawley rats orally received ziram (2 or 4 mg/kg/day) for 4 weeks and immature Leydig cells isolated from 35-day-old rat testes were treated with ziram (0.5-50 μM in vitro). Serum hormones, Leydig cell number and specific gene or protein expression levels after in vivo treatment were determined and medium androgen levels were measured as well as apoptosis of Leydig cells after in vitro treatment were determined...
September 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28971491/plumbagin-improves-the-efficacy-of-androgen-deprivation-therapy-in-prostate-cancer-a-pre-clinical-study
#16
Parisa Abedinpour, Véronique T Baron, Adrian Chrastina, Gaelle Rondeau, Jennifer Pelayo, John Welsh, Per Borgström
BACKGROUND: Plumbagin is a candidate drug for the treatment of prostate cancer. Previous observations indicated that it may improve the efficacy of androgen deprivation therapy (ADT). This study evaluates the effectiveness of treatment with combinations of plumbagin and alternative strategies for ADT in mouse models of prostate cancer to support its clinical use. METHODS: Plumbagin was administered per oral in a new sesame oil formulation. Standard toxicology studies were performed in rats...
December 2017: Prostate
https://www.readbyqxmd.com/read/28967725/testicular-and-thyroid-function-as-survival-predictors-in-the-elderly-patient-candidate-to-surgery
#17
Antonio Aversa, Andrea Fabbri
The relationship between testosterone deficiency (TD) syndrome and surgical resilience has a great impact in the modern approach to male elderly patients. There is good evidence that low levels of T are a strong marker for cardiovascular risk; also, TD is frequently associated with increased cardiovascular and all-cause mortality especially in cardiac older frail men. Screening for low T should be mandatory in high risk groups candidate to surgery including those with diabetes, metabolic syndrome and obesity, even though benefits from T-treatment on survival rates are unclear...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28954263/beneficial-effects-of-high-doses-of-cabergoline-in-the-treatment-of-giant-prolactinoma-resistant-to-dopamine-agonists-a-case-report-with-a-21-year-follow-up
#18
Lucas Faria de Castro, Maria de Fátima Magalhães Gonzaga, Luciana Ansaneli Naves, José Luiz Mendonça, Benicio Oton de Lima, Luiz Augusto Casulari
INTRODUCTION: Prolactinomas are pituitary tumors with a very low prevalence in childhood and adolescence compared to adulthood. This condition is preferentially treated with dopamine agonists. Resistance to these drugs is rare. CASE REPORT: We describe the case of a boy diagnosed with macroadenoma at the age of 9 and followed up for 21 years. He did not fully respond to treatment with dopamine agonists. His initial prolactin level was 2,400 ng/mL (in males, normal values are <16...
September 26, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28938525/toxic-effects-of-tripterygium-wilfordii-hook-f-on-the-reproductive-system-of-adolescent-male-rats
#19
Xiaoping Jing, Weiwei Cheng, Sheng Guo, Ya Zou, Ting Zhang, Li He
Tripterygium wilfordii Hook F. (TWHF) is a compound extracted from Lei Gong Teng (Thunder God Vine) that has been used to treat a variety of immune-related diseases in clinical practice, particularly in pediatrics. Nevertheless, clinical data indicated that glycosides from Tripterygium wilfordii Hook F (GTW) are toxic to the male reproductive system, but the mechanism is unknown. Here, the administration of a high dose of GTW for 4 weeks and a low dose for 12 weeks can reduce the body weights and testes weights in adolescent male rats...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28928235/testosterone-protects-high-fat-low-carbohydrate-diet-induced-non-alcoholic-fatty-liver-disease-in-castrated-male-rats-mainly-via-modulating-er-stress
#20
Yue Jia, Jennifer Kuang Yee, Christina Wang, Liana Nikolaenko, Maruja Diaz-Arjonilla, Joshua N Cohen, Samuel W French, Peter Y Liu, YanHe Lue, Wai-Nang Paul Lee, Ronald S Swerdloff
We previously showed that testosterone (T) deficiency enhanced high-fat diet (HFD) induced hepatic steatosis in rats that was independent of insulin resistance, and that T replacement reduced hepatic macrovesicular fat accumulation and inflammation. The present report explores the mechanism of T-protective effects on HFD-induced steatohepatitis. Adult male rats were randomized into four treatment groups for 15 weeks (intact rats on regular chow diet or HFD, and castrated rats on HFD with/without T replacement)...
September 19, 2017: American Journal of Physiology. Endocrinology and Metabolism
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