Tian-Tian Wang, Hua-Long Zhu, Kong-Wen Ouyang, Hua Wang, Ye-Xin Luo, Xin-Mei Zheng, Qing Ling, Kai-Wen Wang, Jin Zhang, Wei Chang, Qi Lu, Yu-Feng Zhang, Zhi Yuan, Hao Li, Yong-Wei Xiong, Tian Wei, Hua Wang
Low testosterone (T) levels are associated with many common diseases, such as obesity, male infertility, depression, and cardiovascular disease. It is well known that environmental cadmium (Cd) exposure can induce T decline, but the exact mechanism remains unclear. We established a murine model in which Cd exposure induced testicular T decline. Based on the model, we found Cd caused mitochondrial fusion disorder and Parkin mitochondrial translocation in mouse testes. MFN1 overexpression confirmed that MFN1-dependent mitochondrial fusion disorder mediated the Cd-induced T synthesis suppression in Leydig cells...
March 27, 2024: Journal of Hazardous Materials