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Transient receptor potential

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https://www.readbyqxmd.com/read/29652619/circulating-cytokine-chemokine-concentrations-respond-to-ionizing-radiation-doses-but-not-radiation-dose-rates-granulocyte-colony-stimulating-factor-and-interleukin-18
#1
Juliann G Kiang, Joan T Smith, Sara R Hegge, Natalia I Ossetrova
Exposure to ionizing radiation is a crucial life-threatening factor in nuclear and radiological incidents. It is known that ionizing radiation affects cytokine/chemokine concentrations in the blood of B6D2F1 mice. It is not clear whether radiation dose rates would vary the physiological response. Therefore, in this study we utilized data from two experiments using B6D2F1 female mice exposed to six different dose rates ranging from low to high rates. In one experiment, mice received a total dose of 8 Gy (LD0/30 ) of 60 Co gamma radiation at four dose rates: 0...
April 13, 2018: Radiation Research
https://www.readbyqxmd.com/read/29650755/thermosensory-perception-regulates-speed-of-movement-in-response-to-temperature-changes-in-drosophila-melanogaster
#2
Andrea Soto-Padilla, Rick Ruijsink, Ody C M Sibon, Hedderik van Rijn, Jean-Christophe Billeter
Temperature influences physiology and behavior of all organisms. For ectotherms, which lack central temperature regulation, temperature adaptation requires sheltering from or moving to a heat source. As temperature constrains the rate of metabolic reactions, it can directly affect ectotherm physiology and thus behavioral performance. This direct effect is particularly relevant for insects whose small body readily equilibrates with ambient temperature. In fact, models of enzyme kinetics applied to insect behavior predict performance at different temperatures, suggesting that thermal physiology governs behavior...
April 12, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29649466/expression-of-vesicular-glutamate-transporters-in-transient-receptor-potential-ankyrin-1-trpa1-positive-neurons-in-the-rat-trigeminal-ganglion
#3
Yun Sook Kim, Sung Kuk Kim, Jae Sik Lee, Sang Jin Ko, Yong Chul Bae
Transient receptor potential ankyrin 1 (TRPA1), a cold receptor in sensory neurons activated by a variety of stimuli, is implicated in nociception and mechanotransduction. To help understand the vesicular glutamate transporter (VGLUT)-mediated glutamate signaling in TRPA1-immunopositive (+) neurons, we examined the expression of VGLUT1 and VGLUT2 in the TRPA1+ neurons in the male rat trigeminal ganglion (n=19) under normal conditions and following experimental inflammation in the vibrissal pad by light microscopic immunohistochemistry (n=11), western blot (n=8), and quantitative analysis...
April 9, 2018: Brain Research
https://www.readbyqxmd.com/read/29648633/inhibition-of-a-type-k-channels-by-urotensin-ii-induces-sensory-neuronal-hyperexcitability-through-the-pkc%C3%AE-erk-pathway
#4
Yuan Zhang, Hua Wang, Jin Ke, Yuan Wei, Heyi Ji, Zhiyuan Qian, Li Liu, Jin Tao
Previous studies have implicated urotensin-II in the nociception of sensory neurons. However, to date, the relevant mechanisms still remain unknown. In the present study, we determined the role of urotensin-II in the regulation of transient outward A-type potassium currents (IA) as well as neuronal excitability in trigeminal ganglion (TG) neurons. We found that application of urotensin-II to small-diameter TG neurons decreased IA in a dose-dependent manner, while the delayed-rectifier potassium channel current (IDR) was unaffected...
April 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29648595/progesterone-as-a-postnatal-prophylactic-agent-for-encephalopathy-caused-by-prenatal-hypoxic-ischemic-insult
#5
Yoshimasa Kawarai, Hirokazu Tanaka, Tatsuya Kobayashi, Makio Shozu
Brain damage caused by hypoxic ischemic insult during the perinatal period causes hypoxic ischemic encephalopathies (HIEs). Therapeutic hypothermia is indicated for HIE, but since the therapeutic burden is large for its limited therapeutic effectiveness, another strategy is needed. Progesterone (P4) plays a neuroprotective role through the actions of its metabolite, allopregnanolone (Allo), on P4 receptor, GABA (γ-aminobutyric acid)A receptors or both. We examined the therapeutic potential of P4 using a newborn rat model of HIE...
April 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29643714/combined-effect-of-acid-sensing-ion-channel-3-and-transient-receptor-potential-vanilloid-1-gene-polymorphisms-on-blood-pressure-variations-in-taiwanese
#6
Leay-Kiaw Er, Ming-Sheng Teng, Semon Wu, Lung-An Hsu, I-Shiang Tzeng, Ching-Feng Cheng, Hsin-I Chang, Hsin-Hua Chou, Yu-Lin Ko
Objectives: Both acid-sensing ion channel acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) have been proposed to be involved in the pathophysiology of hypertension. Common colocalization of ASIC3 and TRPV1 channels in the same sensory neuron has been reported. We aimed to study the combined ASIC3 and TRPV1 gene polymorphisms in the risk of hypertension. Materials and Methods: To test the statistical association between genetic polymorphisms of the ASIC3 and TRPV1 genes and blood pressure (BP) variations in Taiwanese, 551 unrelated individuals (286 men and 265 women) having routine health examinations were recruited...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29643634/tanezumab-therapy-targeting-nerve-growth-factor-in-pain-pathogenesis
#7
Mona K Patel, Alan D Kaye, Richard D Urman
In recent years, nerve growth factor (NGF) and the NGF receptor have become potential therapeutic targets in the treatment of acute and chronic pain states. NGF is a neurotrophin involved in regulating the function of sensory and sympathetic neurons during development. Numerous pain states have been linked to elevated levels of NGF and its role in increasing the perception of pain. Tanezumab, a recombinant humanized monoclonal antibody (IgG), was developed to target NGF, binding both circulating and local tissue NGF preventing interaction with the tropomyosin-related kinase-A and p75 receptors...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29643035/-correlation-between-expressions-of-vegf-and-trpc6-and-their-roles-in-podocyte-injury-in-rats-with-diabetic-nephropathy
#8
Xiao-Na Zhu, Yu-Huan Wang, Juan-Juan Wu, Peng Dong, Min Zhang
OBJECTIVE: To analyze the correlation between the expressions of vascular endothelial growth factor (VEGF) and transient receptor potential canonical 6 (TRPC6) and their role in podocyte injury in rats with diabetic nephropathy. METHODS: Forty SD rats with diabetic nephropathy induced by intraperitoneal injection of 65 mg/kg streptozotocin were randomized equally into 5 groups, including a diabetic nephropathy model group and 4 treatment groups, with 8 normal SD rats as the normal control group...
March 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29629494/cold-stimuli-facilitate-inflammatory-responses-through-transient-receptor-potential-melastatin-8-trpm8-in-primary-airway-epithelial-cells-of-asthmatic-mice
#9
Haipei Liu, Li Hua, Quanhua Liu, Jun Pan, Yixiao Bao
Bronchial asthma is a chronic inflammatory airway disease that can be aggravated by cold air. However, its mechanism remains largely unknown. As a thermo-sensing cation channel, transient receptor potential melastatin 8 (TRPM8) can be activated by cold stimuli (8-22 °C) and cooling agents. Whereas TRPM8 activation leads to enhanced expression of inflammatory cytokines and mucus hypersecretion in human bronchial epithelial cell lines, no previous study has examined its role in regulating the cold-induced inflammatory responses and its mechanism in asthmatic airway epithelium...
April 9, 2018: Inflammation
https://www.readbyqxmd.com/read/29628598/transient-receptor-potential-channels-as-blood-biomarkers-for-pain-characteristics-in-patients-with-chronic-pain
#10
Norihiko Sukenaga, Munetaka Hirose
Transient receptor potential (TRP) channels play key roles for the transition from acute to chronic postoperative pain after surgery. To evaluate TRP channels in the peripheral blood cells as blood biomarkers for chronic pain, we collected blood samples for genome-wide assays of the mRNA expression and assessed pain intensity and the number of pain symptoms in 13 patients with chronic pain. There was a significant association between increases in the number of pain symptoms and increases in the TRP vanilloid 1 (TRPV1) expression...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628151/safety-of-a-two-dose-investigational-hepatitis-b-vaccine-hbsag-1018-using-a-toll-like-receptor-9-agonist-adjuvant-in-adults
#11
Randall Hyer, Darren K McGuire, Biao Xing, Sam Jackson, Robert Janssen
BACKGROUND: Hepatitis B virus infection remains an important global public health problem. Approved alum-adjuvanted vaccines are well tolerated but require three doses and have reduced immunogenicity in adults. A two-dose vaccine containing hepatitis B surface antigen combined with a novel, Toll-like receptor 9 agonist adjuvant (HBsAg-1018 [HEPLISAV-B®]) has demonstrated significantly higher seroprotection rates than a three dose vaccine. METHODS: A post hoc analysis compared the safety of HBsAg-1018 with HBsAg-Eng (Engerix-B®), in three randomized, observer-blinded, active-controlled, multi-center phase 3 trials in adults...
April 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29627347/trpa1-mediates-the-cardiac-effects-of-acrolein-through-parasympathetic-dominance-but-also-sympathetic-modulation-in-mice
#12
Nicole Kurhanewicz, Allen Ledbetter, Aimen Farraj, Mehdi Hazari
Numerous studies have demonstrated that short-term air pollution exposure causes cardiac autonomic imbalance as measured by heart rate variability (HRV). We previously showed that a single exposure to acrolein, a ubiquitous gaseous component of air pollution, not only causes autonomic imbalance, but also increases arrhythmia through transient receptor potential A1 (TRPA1) cation channels. Thus, the goal of this study was to characterize acrolein-induced autonomic changes in both normal and TRPA1-knockout mice (KO)...
April 5, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29625231/the-oxidized-linoleic-acid-metabolite-12-13-dihome-mediates-thermal-hyperalgesia-during-inflammatory-pain
#13
Béla Zimmer, Carlo Angioni, Tabea Osthues, Andy Toewe, Dominique Thomas, Sandra C Pierre, Gerd Geisslinger, Klaus Scholich, Marco Sisignano
Eicosanoids play a crucial role in inflammatory pain. However, there is very little knowledge about the contribution of oxidized linoleic acid metabolites in inflammatory pain and peripheral sensitization. Here, we identify 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME), a cytochrome P450-derived linoleic acid metabolite, as crucial mediator of thermal hyperalgesia during inflammatory pain. We found 12,13-DiHOME in increased concentrations in peripheral nervous tissue during acute zymosan- and complete Freund's Adjuvant-induced inflammatory pain...
April 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29624776/trpc3-overexpression-and-intervention-in-airway-smooth-muscle-of-ovalbumin-induced-hyperresponsiveness-and-remodeling
#14
Bo-Ming Xu, Jia-Hua Zhang, Jia-Ling Wang, Jun-Hua Xiao
Transient receptor potential canonical channel 3 (TRPC3) proteins function as non-voltage-gated Ca2+ -permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression and airway hyperresponsiveness and remodeling in ovalbumin-induced asthmatic Kunming mice. Mice were sensitized and challenged by ovalbumin to establish asthmatic model. Hematoxylin-eosin staining, hydroxyproline assay and isometric tracheal ring force measurement were used to evaluate airway remodeling and hyperresponsiveness in asthmatic mice...
April 6, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29623922/melastatin-related-transient-receptor-potential-2-channel-in-a%C3%AE-42-induced-neuroinflammation-implications-to-alzheimer-s-disease-mechanism-and-development-of-therapeutics
#15
Linyu Wei, Sharifah Alawieyah Syed Mortadza, Lin-Hua Jiang
No abstract text is available yet for this article.
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29623030/on-the-role-of-store-operated-calcium-entry-in-acute-and-chronic-neurodegenerative-diseases
#16
REVIEW
Agnese Secondo, Giacinto Bagetta, Diana Amantea
In both excitable and non-excitable cells, calcium (Ca2+ ) signals are maintained by a highly integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of plasma membrane (PM) Ca2+ channels following the release of Ca2+ from intracellular stores. Upon depletion of Ca2+ store, the stromal interaction molecule (STIM) senses Ca2+ level reduction and migrates from endoplasmic reticulum (ER)-like sites to the PM where it activates the channel proteins Orai and/or the transient receptor potential channels (TRPC) prompting Ca2+ refilling...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29622593/transient-receptor-potential-melastatin-8-activation-induces-relaxation-of-pulmonary-artery-by-inhibition-of-store-operated-calcium-entry-in-normoxic-and-chronic-hypoxic-pulmonary-hypertensive-rats
#17
Yun-Ping Mu, Da-Cen Lin, Si-Yi Zheng, Hai-Xia Jiao, James Sham, Mo-Jun Lin
Pulmonary hypertension (PH) is characterized by enhanced vasoconstriction and vascular remodeling, which are attributable to the alteration of Ca2+ homeostasis in pulmonary arterial smooth muscle cells (PASMCs). It is well established that store-operated Ca2+ entry (SOCE) is augmented in PASMCs during PH and it plays crucial roles in PH development. Our previous studies showed that the melastatin-related transient receptor potential 8 (TRPM8) is down-regulated in PASMCs of PH animal models; and activation of TRPM8 causes relaxation of pulmonary arteries (PAs)...
April 5, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29621761/transient-receptor-potential-channel-vanilloid-5-induces-chondrocyte-apoptosis-in-a-rat-osteoarthritis-model-through-the-mediation-of-ca2-influx
#18
Yingliang Wei, Dianbin Zheng, Xiaocheng Guo, Min Zhao, Linlin Gao, Lunhao Bai
BACKGROUND/AIMS: Chondrocyte apoptosis is the most common pathological feature in cartilage in osteoarthritis (OA). Transient receptor potential channel vanilloid 5 (TRPV5) is important in regulating calcium ion (Ca2+) influx. Accumulating evidences suggest that Ca2+ is a major intracellular second messenger that can trigger cell apoptosis. Therefore, we investigate the potential role of TRPV5 in mediating Ca2+ influx to promote chondrocyte apoptosis in OA. METHODS: The monoiodoacetic acid (MIA)-induced rat OA model was assessed by macroscopic and radiographic analyses...
March 29, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29620434/transient-receptor-potential-polymorphism-and-haplotype-associate-with-crisis-pain-in-sickle-cell-disease
#19
Ellie H Jhun, Xiaoyu Hu, Nilanjana Sadhu, Yingwei Yao, Ying He, Diana J Wilkie, Robert E Molokie, Zaijie J Wang
AIM: Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genes TRPV1 and TRPA1 with pain in SCD patients. METHODS: Utilization rate, in other words, number of emergency department/acute care center admissions over 12 months as a result of pain crisis, served as a marker for acute pain...
April 5, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29620272/trpm2-promotes-the-proliferation-and-invasion-of-pancreatic-ductal-adenocarcinoma
#20
Rui Lin, Yufeng Wang, Quanning Chen, Zhongyan Liu, Shuai Xiao, Bingyi Wang, Baomin Shi
The aim of the present study was to investigate transient receptor potential cation channel subfamily M member 2 (TRPM2), a promising therapeutic target and biomarker for pancreatic ductal adenocarcinoma (PDAC) prognosis, in addition to determining its effects regarding tumor progression and invasion. PDAC is a fatal disease with a poor prognosis, and its associated pathogenic molecular mechanisms remain to be determined. In the present study, combined analysis using genomic and transcriptomic data from two PDAC studies was performed to discover a survival‑associated biomarker of PDAC...
March 28, 2018: Molecular Medicine Reports
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