Read by QxMD icon Read


Juan Wang, Zhiyuan Fang, Ning Lang, Huishu Yuan, Min-Ying Su, Pierre Baldi
Spinal metastasis, a metastatic cancer of the spine, is the most common malignant disease in the spine. In this study, we investigate the feasibility of automated spinal metastasis detection in magnetic resonance imaging (MRI) by using deep learning methods. To accommodate the large variability in metastatic lesion sizes, we develop a Siamese deep neural network approach comprising three identical subnetworks for multi-resolution analysis and detection of spinal metastasis. At each location of interest, three image patches at three different resolutions are extracted and used as the input to the networks...
March 27, 2017: Computers in Biology and Medicine
Joohak Kim, Alfred P Yoon, Neil F Jones
Background: Toe-to-thumb transfer has become the gold standard for thumb reconstruction, but in badly mutilated hands, additional soft tissue coverage may be required or a suitable recipient artery may not be available. There are only 3 case reports describing the successful use of a reverse radial forearm flap for coverage of a soft tissue defect around the thumb as well as providing arterial inflow for a toe transfer, performed either simultaneously or secondarily. Methods: A single surgeon's experience of all toe-to-hand transfers performed in conjunction with a reverse radial forearm flap between 1995 and 2014 was reviewed, including patient demographics, type of toe transfer and vascular pedicle, whether immediate or secondary, follow-up, and complications...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
Ling Tian, Yi-Tao Deng, Xin Dong, Jia-Yi Fan, Hua-Liang Li, Yu-Mei Ding, Wei-Xi Peng, Qing-Xi Chen, Dong-Yan Shen
Non-small-cell lung cancer (NSCLC) is a widespread and particularly aggressive form of cancer. Patients with NSCLC and early metastases typically have poor prognosis, highlighting the critical need for additional drugs to improve disease outcome following surgical resection. The present study aimed to determine if Siamese crocodile bile (SCB) had an anti‑cancer effect on NCI‑H1299 human NSCLC cells. The inhibitory mechanism of SCB was examined in cell culture and nude mice. In vitro experimental results revealed that SCB inhibited the proliferation and colony‑forming ability of NCI‑H1299 cells by arresting cell cycle and inducing apoptosis...
April 2017: Molecular Medicine Reports
Eric Want-Gauthier, Ilya Golub
We demonstrate a novel method to measure circular birefringence (CB) and linear birefringence (LB) present simultaneously in the device under study. By using a π-shifted Sagnac interferometer, the scheme eliminates the dependence on incoming polarization and on the orientation angle of the linear birefringence. Moreover, due to different handedness symmetry/response of CB and LB to counter-propagating waves, the technique allows us to control the relative influence of the two birefringences leading to a requirement of only two measurements to determine both of them...
March 1, 2017: Optics Letters
Benjamin R Eisenreich, Susan Greene, Allen Szalda-Petree
Aggressive signaling is a key social behavior of male Siamese fighting fish (Betta splendens). Successfully establishing a territory and defending it from intruders has direct fitness effects, making Betta splendens a prime model for studies examining the biological underpinnings of aggressive behavior. Current research has outlined serotonin transporter pathways as one key component for the engagement and coordination of aggressive behavior in Betta splendens. Using the selective serotonin reuptake inhibitor fluoxetine, we examined the impact of 10μmol exposures on associative learning and aggression between mirror and conspecific social reinforcers...
February 22, 2017: Physiology & Behavior
Maryam HedayatiRad, Mohammad Ali Nematollahi, Mohammad Navid Forsatkar, Culum Brown
Previous studies have shown that Siamese fighting fish, Betta splendins, preferentially use right-eye during the aggressive displays. However, administration of antidepressant drugs may disrupt eye-use preference in association with a reduction in aggression; a phenomena that has not been explored in fish. The objective of the current study was to examine the effects of exposure to the antidepressant drug, fluoxetine, on lateralization in eye-use during aggressive displays in male Siamese fighting fish. Baseline aggression and lateralization in eye use of thirty fish were assessed toward live conspecifics, following which experimental subjects (n=15) were then exposed to fluoxetine (540ng/L) in a static renewal water system...
February 22, 2017: Ecotoxicology and Environmental Safety
Narender Kumar, John C Larkin
Cell cycle regulation is fundamental to growth and development, and Cyclin-Dependent Kinase Inhibitors (CKIs) are major negative regulators of the cell cycle. Plant genomes encode substantially more CKIs than metazoan or fungal genomes. Plant CKIs fall into 2 distinct families, KIP-RELATED PROTEINS (KRPs) and SIAMESE-RELATED proteins (SMRs). SMRs can inhibit both S-phase and M-phase CDK complexes in vitro and are transcribed throughout the cell cycle, yet SMRs do not inhibit DNA replication in vivo. This suggests that SMRs must be activated post transcriptionally after the start of S-phase, but the mechanism of this hypothesized activation is unknown...
February 2017: Plant Signaling & Behavior
Anastasia Vogel, Sebastian Dechert, Christian Brückner, Franc Meyer
Siamese-twin porphyrin is a pyrazole-containing expanded porphyrin incorporating two porphyrin-like binding pockets. The macrocycle, however, does not possess an aromatic π system but rather two separated conjugation pathways that are isolated by the pyrazole junctions. Mono- and bimetallic complexes of the Siamese-twin porphyrin are known. This work addresses in detail the electronic consequences that monometalation (with Pd(II)) has on the electronic properties of the nonmetalated binding pocket by studying the solid-state structure, acid/base, and electrochemical properties of the monopalladium twin-porphyrin complex...
February 20, 2017: Inorganic Chemistry
Bung-On Prajanban, Nisachon Jangpromma, Tomohiro Araki, Sompong Klaynongsruang
In light of the increasing threat of bacterial drug resistance to human health on a global scale, research and development of antimicrobial peptides as a novel class of potent antibiotics has gained considerable attention. The present study focuses on the structural evaluation and membrane interaction of two new cationic antimicrobial peptides, cOT2 and sOT2, derived from Siamese crocodile (Crocodylus siamensis) and Chinese softshell turtle (Pelodiscus sinensis) ovotransferrins. Here, cOT1 (+3) and sOT1 (+3) were derived from reptile ovotransferrins by chromatographic purification and characterized by mass spectrometry and N-terminal sequencing analysis...
February 1, 2017: Biochimica et Biophysica Acta
Amalia Agut, Juana D Carrillo, Miryam Martínez, Jose Murciano, Eliseo Belda, Antonio Bernabé, Marta Soler
A 7-month-old, 2.8 kg, intact female Siamese cat was evaluated for repetitive and intermittent episodes of vomiting and anorexia. Abdominal palpation revealed a round, firm, nonpainful mass in the right cranial abdomen. Ultrasonography findings were consistent with a cystic structure adjacent to the descending duodenum. The structure exhibited a "muscular rim sign." A duodenal duplication cyst was confirmed by histopathological analysis. Computed tomography ruled out concurrent vertebral anomalies and clarified anatomic relationships for surgical planning...
January 29, 2017: Veterinary Radiology & Ultrasound
Erich M Schwarz, Adrienne H K Roeder
Endoreduplication is a specialized cell cycle in which DNA replication occurs, but mitosis is skipped creating enlarged polyploid cells. Endoreduplication is associated with the differentiation of many specialized cell types. In the Arabidopsis thaliana sepal epidermis endoreduplicated giant cells form interspersed between smaller cells. Both the transcription factor Arabidopsis thaliana MERISTEM LAYER1 (ATML1) and the plant-specific cyclin dependent kinase inhibitor LOSS OF GIANT CELLS FROM ORGANS (LGO)/SIAMESE RELATED1 (SMR1) are required for the formation of giant cells...
2016: Frontiers in Plant Science
Mohammad Navid Forsatkar, Mohammad Ali Nematollahi, Peter A Biro, Christa Beckmann
Temperature has profound effects on physiology of ectothermic animals. However, the effects on temperature variation on behavioral traits are poorly studied in contrast to physiological endpoints. This may be important as even small differences in temperatures have large effects on physiological rates including overall metabolism, and behavior is known to be linked to metabolism at least in part. The primary aim of this study was to determine the effects of ambient temperature on boldness responses of a species of fish commonly used in behavioral experiments, the Siamese fighting fish (Betta splendens)...
October 15, 2016: Physiology & Behavior
Jing-Hui Zhang, Wei Tang, Zhao-Xi Zhang, Bing-Yi Luan, Sheng-Bo Yu, Hong-Jin Sui
The myodural bridge was proposed initially in 1995. The myodural bridge is a connective tissue bridge that connects a pair of deep muscles at the suboccipital region to the dura mater. There have been numerous studies concerning the morphology and function of the myodural bridge. To determine whether a myodural bridge exists in reptiles, six Siamese crocodiles were investigated using gross anatomy dissection and P45 sheet plastination technologies. As a result, we demonstrated that the posterior occipital muscles of the Siamese crocodile are directly or indirectly connected to the proatlas, atlas, and intermembrane between them...
October 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Wanda M Waterworth, Steven Footitt, Clifford M Bray, William E Finch-Savage, Christopher E West
Genome integrity is crucial for cellular survival and the faithful transmission of genetic information. The eukaryotic cellular response to DNA damage is orchestrated by the DNA damage checkpoint kinases ATAXIA TELANGIECTASIA MUTATED (ATM) and ATM AND RAD3-RELATED (ATR). Here we identify important physiological roles for these sensor kinases in control of seed germination. We demonstrate that double-strand breaks (DSBs) are rate-limiting for germination. We identify that desiccation tolerant seeds exhibit a striking transcriptional DSB damage response during germination, indicative of high levels of genotoxic stress, which is induced following maturation drying and quiescence...
August 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
Kyoo-Tae Kim, Seung-Hun Lee, Dongmi Kwak
A 4-year-old female Siamese crocodile (Crocodylus siamensis) housed at a zoo died without any prior clinical signs. During necropsy, numerous scattered, well-demarcated, yellowish-white, firm nodules were observed throughout the liver and lungs. Microscopic examination with periodic acid-Schiff staining revealed granulomatous inflammation in the liver and lungs. Liver granulomas were characterized by the presence of a connective tissue barrier and hyphae, and the centers of the granulomas showed signs of necrosis...
December 1, 2016: Journal of Veterinary Medical Science
V Duquennoy-Martinot, C Depoortère, C Deveaux, A Capon, O Abdelwahab, C François, P Guerreschi
The expansion of soft tissue, especially skin, is an old and physiological process to increase the skin reserve allowing excision while coveraging of the resulting loss of substance. Easy in principle, this process is subjected to constraints in children requiring precise planning and rigorous technical procedure. Between 1990 and 2016, we performed 293 expansion protocols with 411 implants in 244 children. The scalp was the most interested area (158 cases), followed by the trunk (29). The congenital nevi represented the most frequent indication (119 cases), followed by sequelae of burns and scars (64 cases) and hamartoma sebaceous of Jadassohn (27 cases)...
October 2016: Annales de Chirurgie Plastique et Esthétique
Leslie A Lyons, Robert A Grahn, Francesca Genova, Michela Beccaglia, John J Hopwood, Maria Longeri
The release of new DNA-based diagnostic tools has increased tremendously in companion animals. Over 70 different DNA variants are now known for the cat, including DNA variants in disease-associated genes and genes causing aesthetically interesting traits. The impact genetic tests have on animal breeding and health management is significant because of the ability to control the breeding of domestic cats, especially breed cats. If used properly, genetic testing can prevent the production of diseased animals, causing the reduction of the frequency of the causal variant in the population, and, potentially, the eventual eradication of the disease...
July 2, 2016: BMC Veterinary Research
C Eduardo Siqueira
No abstract text is available yet for this article.
June 20, 2016: Cadernos de Saúde Pública
Preeyanan Anwised, Nisachon Jangpromma, Theeranan Temsiripong, Rina Patramanon, Sakda Daduang, Sarawut Jitrapakdee, Tomohiro Araki, Sompong Klaynongsruang
Recombinant Crocodylus siamensis hemoglobin (cHb) has been constructed and expressed using Escherichia coli as the expression system in conjunction with a trigger factor from the Cold-shock system as the fusion protein. While successful processing as soluble protein in E. coli was achieved, the net yields of active protein from downstream purification processes remained still unsatisfactory. In this study, cHb was constructed and expressed in the eukaryotic expression system Pichia pastoris. The results showed that cHb was excreted from P...
August 2016: Protein Journal
Gareth Arnott, Emma Beattie, Robert W Elwood
Displays are a feature of animal contest behaviour and have been interpreted as a means of gathering information on opponent fighting ability, as well as signalling aggressive motivation. In fish, contest displays often include frontal and lateral elements, which in the latter involves contestants showing their flanks to an opponent. Previous work in a range of fish species has demonstrated population-level lateralization of these displays, preferentially showing one side to their opponent. Mirrors are commonly used in place of a real opponent to study aggression in fish, yet they may disrupt the normal pattern of display behaviour...
August 2016: Behavioural Processes
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"