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Chang Lung Ji

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https://www.readbyqxmd.com/read/29669761/enhancer-remodeling-and-microrna-alterations-are-associated-with-acquired-resistance-to-alk-inhibitors
#1
Mi Ran Yun, Sun Min Lim, Seon-Kyu Kim, Hun Mi Choi, Kyoung Ho Pyo, Seong Keun Kim, Ji Min Lee, You Won Lee, Jae Woo Choi, Hye Ryun Kim, Min Hee Hong, Keeok Haam, Nanhyung Huh, Jong Hwan Kim, Yong Sung Kim, Hyo Sup Shim, Ross Andrew Soo, Jin-Yuan Shih, James Chih-Hsin Yang, Mirang Kim, Byoung Chul Cho
Anaplastic lymphoma kinase (ALK) inhibitors are highly effective in ALK fusion-positive lung cancer patients, but acquired resistance invariably emerges. Identification of secondary mutations has received considerable attention, but most cases cannot be explained by genetic causes alone, raising the possibility of epigenetic mechanisms in acquired drug resistance. Here we investigated the dynamic changes in the transcriptome and enhancer landscape during development of acquired resistance to ALK inhibitors...
April 18, 2018: Cancer Research
https://www.readbyqxmd.com/read/29651825/feasibility-of-using-optical-coherence-tomography-to-detect-acute-radiation-induced-esophageal-damage-in-small-animal-models
#2
Pouya Jelvehgaran, Daniel Martijn de Bruin, F Javier Salguero, Gerben Roelof Borst, Ji-Ying Song, Ton G van Leeuwen, Johannes F de Boer, Tanja Alderliesten, Marcel van Herk
Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10  μm) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose delivery of 4...
April 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29627816/effects-of-dietary-antioxidant-vitamins-on-lung-functions-according-to-gender-and-smoking-status-in-korea-a-population-based-cross-sectional-study
#3
Ji Young Hong, Chang Youl Lee, Myung Goo Lee, Young Sam Kim
OBJECTIVE: Cigarette smoke-induced oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Dietary antioxidants are thought to prevent smoke-induced oxidative damage. The aim of this study was to investigate associations between lung function and the consumption of antioxidant vitamins in Korean adults. METHODS: In total, 21 148 participants from the Korean National Health and Nutrition Examination Survey (2007-2014) were divided into four groups based on smoking history and gender...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29625134/il-17-producing-st2-ilc2-plays-a-pathogenic-role-in-lung-inflammation
#4
Ting Cai, Jinxin Qiu, Yan Ji, Wenjing Li, Zhaoyun Ding, Caixia Suo, Jiali Chang, Jingjing Wang, Rui He, Youcun Qian, Xiaohuan Guo, Liang Zhou, Huiming Sheng, Lei Shen, Ju Qiu
BACKGROUND: IL-17 plays a pathogenic role in asthma. ST2- iILC2s (inflammatory group 2 innate lymphoid cells) driven by IL-25 can produce IL-17, while ST2+ nILC2s (natural ILC2s) produce few IL-17. OBJECTIVE: We characterized the ST2+ IL-17+ ILC2s during lung inflammation and determined the pathogenesis and molecular regulation of ST2+ IL-17+ ILC2s. METHODS: Lung inflammation was induced by papain or IL-33. IL-17 production by lung ILC2s from wild-type, Rag1-/- , Rorcgfp/gfp and Ahr-/- mice was examined by flow cytometry...
April 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29593694/amino-acid-substitutions-ha-a150v-pa-a343t-and-pb2-e627k-increase-the-virulence-of-h5n6-influenza-virus-in-mice
#5
Xiuming Peng, Fumin Liu, Haibo Wu, Xiaorong Peng, Yufan Xu, Liyan Wang, Bin Chen, Tao Sun, Fan Yang, Shujing Ji, Nanping Wu
H5N6 avian influenza viruses (AIVs) can cause severe pneumonia and death in humans. However, the molecular determinants of H5N6 influenza virus mammalian adaption are still unclear. Three amino acid substitutions (HA A150V, PA A343T, PB2 E627K) are observed in H5N6 virus A/duck/Zhejiang/6D2/2013 (6D2) in lung-to-lung passage in mice. These substitutions are crucial to the pathogenicity of mouse-adapted virus. In this study, we investigated the contribution of each amino acid substitution in the virus by reverse genetics...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29581791/usefulness-of-bronchoscopic-rebiopsy-of-non-small-cell-lung-cancer-with-acquired-resistance-to-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor
#6
Eun Kyong Goag, Jung Mo Lee, Kyung Soo Chung, Song Yee Kim, Ah Young Leem, Joo Han Song, Ji Ye Jung, Moo Suk Park, Yoon Soo Chang, Young Sam Kim, Joon Chang, Eun Young Kim
Background : Approximately 50% of non-small cell lung cancer (NSCLC) patients with acquired resistance to EGFR-TKI harbor the EGFR mutation T790M. The recent development and wide use of third-generation EGFR-TKIs targeting T790M-mutant NSCLCs have increased the importance of rebiopsy after EGFR-TKI failure. We aimed to investigate the advantages of flexible bronchoscopy as a rebiopsy method and the prevalence of and factors affecting the T790M mutation after EGFR-TKI failure. Methods : We investigated 139 patients who had undergone bronchoscopic rebiopsy and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) between Sep 2014 and Jul 2016...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29547542/transepithelial-fluid-and-salt-re-absorption-regulated-by-cgk2-signals
#7
REVIEW
Jianjun Chang, Yan Ding, Zhiyu Zhou, Hong-Guang Nie, Hong-Long Ji
Transepithelial fluid and salt re-absorption in epithelial tissues play an important role in fluid and salt homeostasis. In absorptive epithelium, fluid and salt flux is controlled by machinery mainly composed of epithelial sodium channels (ENaC), cystic fibrosis transmembrane conductance regulator (CFTR), Na⁺/H⁺ exchanger (NHE), aquaporin, and sodium potassium adenosine triphosphatase (Na⁺/K⁺-ATPase). Dysregulation of fluid and salt transport across epithelium contributes to the pathogenesis of many diseases, such as pulmonary edema and cystic fibrosis...
March 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29528793/randomized-double-blind-placebo-controlled-multicenter-phase-ii-study-of-fruquintinib-after-two-prior-chemotherapy-regimens-in-chinese-patients-with-advanced-nonsquamous-non%C3%A2-small-cell-lung-cancer
#8
Shun Lu, Jianhua Chang, Xiaoqing Liu, Jianhua Shi, You Lu, Wei Li, Jin-Ji Yang, Jianying Zhou, Jie Wang, Tongtong An, Lei Yang, Zhe Liu, Xiangdong Zhou, Mo Chen, Ye Hua, Weiguo Su
Purpose Patients with advanced non‒small-cell lung cancer (NSCLC) who fail two lines of chemotherapy have unmet medical needs. The kinase inhibitor fruquintinib selectively targets vascular endothelial growth factor receptors and, hence, tumor angiogenesis and lymphogenesis. This randomized, double-blind, placebo-controlled, multicenter phase II trial evaluated the efficacy and safety of fruquintinib in patients with advanced nonsquamous NSCLC who experienced disease progression after second-line chemotherapy...
March 12, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29527844/altered-thoracic-cage-dimensions-in-patients-with-chronic-obstructive-pulmonary-disease
#9
Su Jin Lim, Ju Young Kim, Seung Jun Lee, Gi Dong Lee, Yu Ji Cho, Yi Yeong Jeong, Kyung Nyeo Jeon, Jong Deog Lee, Jang Rak Kim, Ho Cheol Kim
BACKGROUND: Chronic obstructive pulmonary disease (COPD) may cause changes in the shape of the thoracic cage by increasing lung volume and hyperinflation. This study investigated changes in thoracic cage dimensions and related factors in patients with COPD. METHODS: We enrolled 85 patients with COPD (76 males, 9 females; mean age, 70.6±7.1 years) and 30 normal controls. Thoracic cage dimensions were measured using chest computed tomography at levels 3, 6, and 9 of the thoracic spine...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527840/increased-risk-of-exacerbation-in-asthma-predominant-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome
#10
Jisoo Park, Eun Kyung Kim, Mi Ae Kim, Tae Hyung Kim, Jung Hyun Chang, Yon Ju Ryu, Sei Won Lee, Yeon Mok Oh, Suk Joong Yong, Won Il Choi, Kwang Ha Yoo, Ji Hyun Lee
BACKGROUND: Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. METHODS: A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29517574/perioperative-management-may-improve-long-term-survival-in-patients-after-lung-cancer-surgery-a-retrospective-cohort-study
#11
Wen-Wen Huang, Wen-Zhi Zhu, Dong-Liang Mu, Xin-Qiang Ji, Xiao-Lu Nie, Xue-Ying Li, Dong-Xin Wang, Daqing Ma
BACKGROUND: Surgical resection is the main treatment for patients with non-small-cell lung cancer (NSCLC), but patients' long-term outcome is still challenging. The purpose of this study was to identify predictors of long-term survival in patients after lung cancer surgery. METHODS: Patients who underwent surgery for NSCLC from January 1, 2006, to December 31, 2009, were enrolled into this retrospective cohort study. The primary outcome was the survival length after surgery...
March 6, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29496042/cd70-as-a-target-for-chimeric-antigen-receptor-t-cells-in-head-and-neck-squamous-cell-carcinoma
#12
Yuk Pheel Park, Linchun Jin, Katie B Bennett, Dunrui Wang, Kristianna M Fredenburg, Jennifer E Tseng, Lung-Ji Chang, Jianping Huang, Edward K L Chan
OBJECTIVES: In accordance with the Precision Medicine Initiative, new treatment strategies for head and neck squamous cell carcinoma (HNSCC) are needed to yield better therapeutic outcomes. The purpose of this study was to establish and validate chimeric antigen receptor (CAR)-T cells targets in HNSCC. METHODS: Putative CAR-T antigens were identified in The Cancer Genome Atlas database. To validate antigen suitability, quantitative RT-PCR, flow cytometry, and immunofluorescent staining were performed...
March 2018: Oral Oncology
https://www.readbyqxmd.com/read/29484424/knockdown-of-end-binding-protein-1-induces-apoptosis-in-radioresistant-a549-lung-cancer-cells-via-p38-kinase-dependent-cox-2-upregulation
#13
Jeong-Hwa Baek, Ji-Hye Yim, Jie-Young Song, Hong-Duck Um, Jong Kuk Park, In-Chul Park, Jae-Sung Kim, Chang-Woo Lee, Eun-Hee Hong, Eun Ho Kim, Sang-Gu Hwang
The role of end-binding protein 1 (EB1) in lung cancer tumorigenesis and radiotherapy remains poorly understood. In the present study, we observed that EB1 was highly expressed in lung tumor tissues compared with normal non-tumor tissues based on immunohistochemical analysis of lung cancer tissue samples obtained from human tissue microarrays. EB1 was also highly overexpressed in radioresistant lung and cervical cancer cells, which exhibited increased cell death after EB1 silencing. The cytotoxicity induced by EB1 gene knockdown was due to the activation and generation of reactive oxygen species by p38 mitogen-activated protein kinase...
February 22, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29466698/erk1-2-mtor-stat3-pathway-mediated-autophagy-alleviates-traumatic-brain-injury-induced-acute-lung-injury
#14
Xiupeng Xu, Tongle Zhi, Zhongyuan Bao, Kuan Jiang, Yinlong Liu, Honglu Chao, Liang Fan, Dong Wang, Zheng Li, Ning Liu, Jing Ji
Acute lung injury (ALI) is one of several complications in patients with traumatic brain injury (TBI). Autophagy is a primary homeostatic process that promotes cell survival under stress. Accumulating evidence implicates autophagy in the pathogenesis of ALI under various conditions. However, the role of autophagy in TBI-induced ALI remains unknown. The aim of this study was to adjust autophagy with pharmacological agents to determine its functional significance in TBI-induced ALI. Rats were preconditioned with autophagy promoter rapamycin or inhibitor 3-methyladenine before they were challenged with TBI...
February 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29454913/restoring-th17-treg-balance-via-modulation-of-stat3-and-stat5-activation-contributes-to-the-amelioration-of-chronic-obstructive-pulmonary-disease-by-bufei-yishen-formula
#15
Peng Zhao, Jiansheng Li, Yange Tian, Jing Mao, Xuefang Liu, Suxiang Feng, Junzi Li, Qingqing Bian, Huige Ji, Lanxi Zhang
ETHNOPHARMACOLOGY RELEVANCE: Bufei Yishen formula (BYF), a Traditional Chinese Medicine (TCM), has been extensively applied in clinical treatment of chronic obstructive pulmonary disease (COPD) and provides an effective treatment strategy for the syndrome of lung-kidney qi deficiency in COPD patients. Here, we investigated its anti-COPD mechanism in COPD rats in relation to the balance between T helper (Th) 17 cells and regulatory T (Treg) cells. METHODS: Rat model of cigarette smoke- and bacterial infection-induced COPD was established, and orally treated with BYF for 12 consecutive weeks...
May 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29424539/novel-ligustrazine-based-analogs-of-piperlongumine-potently-suppress-proliferation-and-metastasis-of-colorectal-cancer-cells-in-vitro-and-in-vivo
#16
Yu Zou, Di Zhao, Chang Yan, Yanpeng Ji, Jin Liu, Jinyi Xu, Yisheng Lai, Jide Tian, Yihua Zhang, Zhangjian Huang
Piperlongumine 1 increases reactive oxygen species (ROS) levels and preferably induces cancer cell apoptosis by triggering different pathways. However, the poor solubility of 1 limits its intensive investigation and clinical application. Ligustrazine possesses a water-soluble pyrazine skeleton and can inhibit proliferation and metastasis of cancer cells. We synthesized compound 3 by replacement of the trimethoxyphenyl of 1 with ligustrazine moiety, and further introduced 2-Cl, -Br, and -I to 3 for synthesis of 4-6, respectively...
February 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29416619/the-inhibitory-activity-of-gallic-acid-against-dna-methylation-application-of-gallic-acid-on-epigenetic-therapy-of-human-cancers
#17
Yui-Ping Weng, Pin-Feng Hung, Wen-Yen Ku, Chang-Yuan Chang, Bo-Han Wu, Ming-Han Wu, Jau-Ying Yao, Ji-Rui Yang, Chia-Huei Lee
Epigenome aberrations have been observed in tobacco-associated human malignancies. (-)-epigallocatechin-3-gallate (EGCG) has been proven to modulate gene expression by targeting DNA methyltransferases (DNMTs) through a proposed mechanism involving the gallate moiety of EGCG. We show that gallic acid (GA) changes the methylome of lung cancer and pre-malignant oral cell lines and markedly reduces both nuclear and cytoplasmic DNMT1 and DNMT3B within 1 week. GA exhibits stronger cytotoxicity against the lung cancer cell line H1299 than EGCG...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29407953/design-semisynthesis-%C3%AE-glucosidase-inhibitory-cytotoxic-and-antibacterial-activities-of-p-terphenyl-derivatives
#18
Xue-Qing Zhang, Xiao-Feng Mou, Ning Mao, Jie-Jie Hao, Ming Liu, Ji-Yong Zheng, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao
Terphenyllin (1), a naturally abundant p-terphenyl metabolite, was isolated from the coral derived fungus Aspergillus candidus together with four natural analogues 2-5. To evaluate their potency and selectivity, a series of new derivatives of 1 were designed and semisynthesized. They were evaluated for their α-glucosidase inhibitory, cytotoxic, and antibacterial activities. Compounds 1, 3, 4, 7, 8, 10, 11, 14, 15, 21, 23, 24, 29, 39, and 40 showed significant α-glucosidase inhibitory activity with IC50 values of 4...
February 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29407486/antiviral-and-anti-inflammatory-activity-of-budesonide-against-human-rhinovirus-infection-mediated-via-autophagy-activation
#19
Seong-Ryeol Kim, Jae-Hyoung Song, Jae-Hee Ahn, Geun-Shik Lee, Huijeong Ahn, Sung-Il Yoon, Seung Goo Kang, Pyeung-Hyeun Kim, Sang-Min Jeon, Eun-Ji Choi, Sooyoung Shin, Younggil Cha, Sungchan Cho, Dong-Eun Kim, Sun-Young Chang, Hyun-Jeong Ko
Human rhinovirus (HRV) infection causes more than 80% of all common colds and is associated with severe complications in patients with asthma and chronic obstructive pulmonary disease. To identify antiviral drug against HRV infection, we screened 800 FDA-approved drugs and found budesonide as one of the possible drug candidates. Budesonide is a corticosteroid, which is commonly used to prevent exacerbation of asthma and symptoms of common cold. Budesonide specifically protects host cells from cytotoxicity following HRV infection, which depend on the expression of glucocorticoid receptor...
February 1, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29403003/regulation-of-chitinase-3-like-1-in-t-cell-elicits-th1-and-cytotoxic-responses-to-inhibit-lung-metastasis
#20
Do-Hyun Kim, Hong-Jai Park, Sangho Lim, Ja-Hyun Koo, Hong-Gyun Lee, Jin Ouk Choi, Ji Hoon Oh, Sang-Jun Ha, Min-Jong Kang, Chang-Min Lee, Chun Geun Lee, Jack A Elias, Je-Min Choi
Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknown. Here we show that Chi3l1 expression was increased in activated T cells, especially in Th2 cells. In addition, Chi3l1-deficient T cells are hyper-responsive to TcR stimulation and are prone to differentiating into Th1 cells. Chi3l1-deficient Th1 cells show increased expression of anti-tumor immunity genes and decreased Th1 negative regulators...
February 5, 2018: Nature Communications
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