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Chang Lung Ji

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https://www.readbyqxmd.com/read/29466698/erk1-2-mtor-stat3-pathway-mediated-autophagy-alleviates-traumatic-brain-injury-induced-acute-lung-injury
#1
Xiupeng Xu, Tongle Zhi, Zhongyuan Bao, Kuan Jiang, Yinlong Liu, Honglu Chao, Liang Fan, Dong Wang, Zheng Li, Ning Liu, Jing Ji
Acute lung injury (ALI) is one of several complications in patients with traumatic brain injury (TBI). Autophagy is a primary homeostatic process that promotes cell survival under stress. Accumulating evidence implicates autophagy in the pathogenesis of ALI under various conditions. However, the role of autophagy in TBI-induced ALI remains unknown. The aim of this study was to adjust autophagy with pharmacological agents to determine its functional significance in TBI-induced ALI. Rats were preconditioned with autophagy promoter rapamycin or inhibitor 3-methyladenine before they were challenged with TBI...
February 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29454913/restoring-th17-treg-balance-via-modulation-of-stat3-and-stat5-activation-contributes-to-the-amelioration-of-chronic-obstructive-pulmonary-disease-by-bufei-yishen-formula
#2
Peng Zhao, Jiansheng Li, Yange Tian, Jing Mao, Xuefang Liu, Suxiang Feng, Junzi Li, Qingqing Bian, Huige Ji, Lanxi Zhang
ETHNOPHARMACOLOGY RELEVANCE: Bufei Yishen formula (BYF), a Traditional Chinese Medicine (TCM), has been extensively applied in clinical treatment of chronic obstructive pulmonary disease (COPD) and provides an effective treatment strategy for the syndrome of lung-kidney qi deficiency in COPD patients. Here, we investigated its anti-COPD mechanism in COPD rats in relation to the balance between T helper (Th) 17 cells and regulatory T (Treg) cells. METHODS: Rat model of cigarette smoke- and bacterial infection-induced COPD was established, and orally treated with BYF for 12 consecutive weeks...
February 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29424539/novel-ligustrazine-based-analogs-of-piperlongumine-potently-suppress-proliferation-and-metastasis-of-colorectal-cancer-cells-in-vitro-and-in-vivo
#3
Yu Zou, Di Zhao, Chang Yan, Yanpeng Ji, Jin Liu, Jinyi Xu, Yisheng Lai, Jide Tian, Yihua Zhang, Zhangjian Huang
Piperlongumine 1 increases reactive oxygen species (ROS) levels and preferably induces cancer cell apoptosis by triggering different pathways. However, the poor solubility of 1 limits its intensive investigation and clinical application. Ligustrazine possesses a water-soluble pyrazine skeleton and can inhibit proliferation and metastasis of cancer cells. We synthesized compound 3 by replacement of the trimethoxyphenyl of 1 with ligustrazine moiety, and further introduced 2-Cl, -Br, and -I to 3 for synthesis of 4-6, respectively...
February 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29416619/the-inhibitory-activity-of-gallic-acid-against-dna-methylation-application-of-gallic-acid-on-epigenetic-therapy-of-human-cancers
#4
Yui-Ping Weng, Pin-Feng Hung, Wen-Yen Ku, Chang-Yuan Chang, Bo-Han Wu, Ming-Han Wu, Jau-Ying Yao, Ji-Rui Yang, Chia-Huei Lee
Epigenome aberrations have been observed in tobacco-associated human malignancies. (-)-epigallocatechin-3-gallate (EGCG) has been proven to modulate gene expression by targeting DNA methyltransferases (DNMTs) through a proposed mechanism involving the gallate moiety of EGCG. We show that gallic acid (GA) changes the methylome of lung cancer and pre-malignant oral cell lines and markedly reduces both nuclear and cytoplasmic DNMT1 and DNMT3B within 1 week. GA exhibits stronger cytotoxicity against the lung cancer cell line H1299 than EGCG...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29407953/design-semisynthesis-%C3%AE-glucosidase-inhibitory-cytotoxic-and-antibacterial-activities-of-p-terphenyl-derivatives
#5
Xue-Qing Zhang, Xiao-Feng Mou, Ning Mao, Jie-Jie Hao, Ming Liu, Ji-Yong Zheng, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao
Terphenyllin (1), a naturally abundant p-terphenyl metabolite, was isolated from the coral derived fungus Aspergillus candidus together with four natural analogues 2-5. To evaluate their potency and selectivity, a series of new derivatives of 1 were designed and semisynthesized. They were evaluated for their α-glucosidase inhibitory, cytotoxic, and antibacterial activities. Compounds 1, 3, 4, 7, 8, 10, 11, 14, 15, 21, 23, 24, 29, 39, and 40 showed significant α-glucosidase inhibitory activity with IC50 values of 4...
February 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29407486/antiviral-and-anti-inflammatory-activity-of-budesonide-against-human-rhinovirus-infection-mediated-via-autophagy-activation
#6
Seong-Ryeol Kim, Jae-Hyoung Song, Jae-Hee Ahn, Geun-Shik Lee, Huijeong Ahn, Sung-Il Yoon, Seung Goo Kang, Pyeung-Hyeun Kim, Sang-Min Jeon, Eun-Ji Choi, Sooyoung Shin, Younggil Cha, Sungchan Cho, Dong-Eun Kim, Sun-Young Chang, Hyun-Jeong Ko
Human rhinovirus (HRV) infection causes more than 80% of all common colds and is associated with severe complications in patients with asthma and chronic obstructive pulmonary disease. To identify antiviral drug against HRV infection, we screened 800 FDA-approved drugs and found budesonide as one of the possible drug candidates. Budesonide is a corticosteroid, which is commonly used to prevent exacerbation of asthma and symptoms of common cold. Budesonide specifically protects host cells from cytotoxicity following HRV infection, which depend on the expression of glucocorticoid receptor...
February 1, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29403003/regulation-of-chitinase-3-like-1-in-t-cell-elicits-th1-and-cytotoxic-responses-to-inhibit-lung-metastasis
#7
Do-Hyun Kim, Hong-Jai Park, Sangho Lim, Ja-Hyun Koo, Hong-Gyun Lee, Jin Ouk Choi, Ji Hoon Oh, Sang-Jun Ha, Min-Jong Kang, Chang-Min Lee, Chun Geun Lee, Jack A Elias, Je-Min Choi
Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknown. Here we show that Chi3l1 expression was increased in activated T cells, especially in Th2 cells. In addition, Chi3l1-deficient T cells are hyper-responsive to TcR stimulation and are prone to differentiating into Th1 cells. Chi3l1-deficient Th1 cells show increased expression of anti-tumor immunity genes and decreased Th1 negative regulators...
February 5, 2018: Nature Communications
https://www.readbyqxmd.com/read/29399809/the-differential-expression-of-the-blood-group-p1-a4galt-and-p2-a4galt-alleles-is-stimulated-by-the-transcription-factor-early-growth-response-1
#8
Chih-Chun Yeh, Ching-Jin Chang, Yuh-Ching Twu, Shu-Ting Hung, Yi-Jui Tsai, Jia-Ching Liao, Ji-Ting Huang, Yu-Hsin Kao, Sheng-Wei Lin, Lung-Chih Yu
BACKGROUND: The P1 /P2 phenotypic polymorphism is one of the earliest blood groups discovered in humans. These blood groups have been connected to different levels of expression of the A4GALT gene in P1 and P2 red blood cells; however, the detailed molecular genetic mechanism that leads to these two phenotypes has not been established. STUDY DESIGN AND METHODS: After our previous identification of an association between the single-nucleotide polymorphisms (SNPs) rs2143918 and rs5751348 in A4GALT gene and the P1 /P2 phenotype, we conduct a survey of transcription factors that might connect these SNPs with the differential expression of the P1 -A4GALT and P2 -A4GALT alleles...
February 4, 2018: Transfusion
https://www.readbyqxmd.com/read/29390328/foregut-duplication-cyst-a-novel-computed-tomography-finding-mimicking-a-small-bowel-hernia-a-case-report
#9
Ji Eun Choi, Soyeoun Lim, Chang Ryul Park, Hee Jeong Cha, Woon-Jung Kwon
RATIONALE: A foregut duplication cyst (FDC) is an uncommon congenital disease. This report presents a case of mediastinal foregut duplication cyst that mimicked a diaphragmatic small bowel hernia. PATIENT CONCERN: A 27-month-old girl was first referred for a mediastinal lesion found incidentally on a chest radiograph. At that time, our impression was cystic lung lesion such as congenital pulmonary airway malformation or pulmonary sequestration. At the age 6 years, she presented with recurrent vomiting...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29385887/short-term-inhalation-study-of-graphene-oxide-nanoplates
#10
Young Hun Kim, Mi Seong Jo, Jin Kwon Kim, Jae Hoon Shin, Jin Ee Baek, Hye Seon Park, Hyo Jin An, Jong Seong Lee, Boo Wook Kim, Hoi Pin Kim, Kang Ho Ahn, KiSoo Jeon, Seung Min Oh, Ji Hyun Lee, Tomomi Workman, Elaine M Faustman, Il Je Yu
Graphene oxides possess unique physicochemical properties with important potential applications in electronics, pharmaceuticals, and medicine. However, the toxicity following inhalation exposure to graphene oxide has not yet been clarified. Therefore, this study conducted a short-term graphene oxide inhalation toxicity analysis using a nose-only inhalation exposure system and male Sprague-Dawley rats. A total of four groups (15 rats per group) were exposed: (1) control (fresh air), (2) low concentration (0...
February 1, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29368644/differences-in-do-not-resuscitate-orders-hospice-care-utilization-and-late-referral-to-hospice-care-between-cancer-and-non-cancer-decedents-in-a-tertiary-hospital-in-taiwan-between-2010-and-2015-a-hospital-based-observational-study
#11
Tzu-Chien Shih, Hsiao-Ting Chang, Ming-Hwai Lin, Chun-Ku Chen, Tzeng-Ji Chen, Shinn-Jang Hwang
BACKGROUND: In 2009, the Taiwanese national health insurance system substantially expanded hospice coverage for terminal cancer patients to include patients with end-stage brain, dementia, heart, lung, liver, and kidney diseases. This study aimed to evaluate differences in do-not-resuscitate (DNR) status and hospice care utilization between terminal cancer patients and advanced non-cancer patients after the policy change. METHODS: Data were obtained from the Death and Hospice Palliative Care Database of Taipei Veterans General Hospital in Taiwan...
January 24, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29359540/association-between-genetic-variations-of-mertk-and-chronic-obstructive-pulmonary-disease-in-koreans
#12
Woo Jin Kim, Hyo Jin Park, Yang Ji Choi, Eun Young Kwon, Bo Min Kim, Jin Hwa Lee, Jung Hyun Chang, Jihee Lee Kang, Ji Ha Choi
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease. To date, a large number of clinical studies have been conducted to investigate the association between genetic variations and COPD. However, little is known regarding the genetic susceptibility of Koreans to this disease. MER receptor tyrosine kinase (MERTK) plays important roles in the inhibition of inflammation and in the clearance of apoptotic cells. Here, we investigated the association between genetic variations in MERTK and the development of COPD in Koreans...
February 12, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29357857/the-genotoxicity-of-an-aqueous-extract-of-gyejibokryeong-hwan
#13
Mee-Young Lee, Chang-Seob Seo, Hyekyung Ha, Eunsook Park, Ji-Young Kim, Hyeun-Kyoo Shin
BACKGROUND: Gyejibokryeong-hwan (Guizhi Fuling Wan in China), a mixture of five herbal plants, is a well-known treatment for renal diseases including those associated with climacteric syndrome. However, the genotoxicity of Gyejibokryeong-hwan has not yet been well established. METHODS: The present study investigated that the genotoxicity of an aqueous extract of Gyejibokryeong-hwan (GJBRHE): an in vitro chromosomal aberration test using Chinese hamster lung cells, an in vitro bacterial reverse mutation assay (Ames test) with Salmonella typhimurium and Escherichia coli strains, and an in vivo micronucleus test using ICR mouse bone marrow...
January 22, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29344298/akr1c1-activates-stat3-to-promote-the-metastasis-of-non-small-cell-lung-cancer
#14
Hong Zhu, Lin-Lin Chang, Fang-Jie Yan, Yan Hu, Chen-Ming Zeng, Tian-Yi Zhou, Tao Yuan, Mei-Dan Ying, Ji Cao, Qiao-Jun He, Bo Yang
Metastasis is the leading cause of mortality for human non-small cell lung cancer (NSCLC). However, it is difficult to target tumor metastasis because the molecular mechanisms underlying NSCLC invasion and migration remain unclear. Methods: GEO data analyses and IHC analyses were performed to identify that the expression level of AKR1C1, a member of human aldo-keto reductase family, was highly elevated in patients with metastasis or metastatic foci of NSCLC patients. Functional analyses (in vitro and in vivo) and quantitative genomic analyses were preformed to confirm the pro-metastatic effects of AKR1C1 and the underlying mechanisms...
2018: Theranostics
https://www.readbyqxmd.com/read/29328670/the-surface-oxidation-of-graphene-oxide-determines-membrane-damage-lipid-peroxidation-and-cytotoxicity-in-macrophages-in-a-pulmonary-toxicity-model
#15
Ruibin Li, Linda M Guiney, Chong Hyun Chang, Nikhita D Mansukhani, Zhaoxia Ji, Xiang Wang, Yu-Pei Liao, Wen Jiang, Bingbing Sun, Mark C Hersam, Andre E Nel, Tian Xia
While 2-dimensional graphene oxide (GO) is used increasingly in biomedical applications, there is uncertainty on how specific physicochemical properties relate to biocompatibility in mammalian systems. Although properties such as lateral size and the colloidal properties of the nanosheets are important, the specific material properties that we address here is the oxidation state and reactive surface groups on the planar surface. In this study, we used a GO library, comprised of pristine, reduced (rGO), and hydrated GO (hGO), in which quantitative assessment of the hydroxyl, carboxyl, epoxy and carbon radical contents were used to study the impact on epithelial cells and macrophages, as well as in the murine lung...
January 12, 2018: ACS Nano
https://www.readbyqxmd.com/read/29312713/outcomes-of-perioperative-extracorporeal-membrane-oxygenation-use-in-patients-undergoing-lung-transplantation
#16
Joo Han Song, Ji Eun Park, Jin Gu Lee, Chang Young Lee, Kyung Sik Nam, Jee Won Suh, Anes Kim, Seung Hyun Lee, Hyun Chel Joo, Young Nam Youn, Song Yee Kim, Moo Suk Park, Hyo Chae Paik
Background: The aim of this single-center study is to review the transplant outcomes of patients receiving lung transplantation (LTx) using intraoperative extracorporeal membrane oxygenation (ECMO) according to the perioperative use of ECMO. Methods: We retrospectively reviewed the transplant outcomes of 107 consecutive patients who underwent LTx using intraoperative ECMO between March 2013 and August 2016 at Severance Hospital of Yonsei University (Seoul, Korea)...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29312707/rare-causes-of-hyperbilirubinemia-after-lung-transplantation-our-experience-at-a-single-center
#17
Su Hwan Lee, Moo Suk Park, Jin Gu Lee, Joo Han Song, Kyung Soo Chung, Ji Ye Jung, Eun Young Kim, Young Sam Kim, Se Kyu Kim, Joon Chang, Hyo Chae Paik, Song Yee Kim
Background: Lung transplantation is the last treatment option for end-stage lung disease, and the number of lung transplantations has been steadily increasing. Hyperbilirubinemia is a rare complication after lung transplantation. The aim of this study was to review rare causes of hyperbilirubinemia after lung transplantation at our center. Methods: In this single-center study, we retrospectively reviewed the records of 116 consecutive lung transplantation patients who underwent lung transplantation at Severance Hospital and Gangnam Severance Hospital of Yonsei University College of Medicine in South Korea between December 22, 2010 and January 1, 2016...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29311420/computer-aided-diagnosis-of-lung-cancer-the-effect-of-training-datasets-on-classification-accuracy-of-lung-nodules
#18
Jing Gong, Ji-Yu Liu, Xi-Wen Sun, Bin Zheng, Sheng-Dong Nie
This study aims to develop a computer-aided diagnosis (CADx) scheme for classification between malignant and benign lung nodules, and also assess whether CADx performance changes in detecting nodules associated with early and advanced stage lung cancer. Methods: The study involves 243 biopsy-confirmed pulmonary nodules. Among them, 76 are benign, 81 are stage I and 86 are stage III malignant nodules. Cases are partitioned into 3 datasets involving: (1) all nodules, (2) benign and stage I malignant nodules, and (3) benign and stage III malignant nodules...
January 9, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29305734/olipudase-alfa-for-treatment-of-acid-sphingomyelinase-deficiency-asmd-safety-and-efficacy-in-adults-treated-for-30-months
#19
Melissa P Wasserstein, George A Diaz, Robin H Lachmann, Marie-Hélène Jouvin, Indrani Nandy, Allena J Ji, Ana Cristina Puga
Olipudase alfa, a recombinant human acid sphingomyelinase (ASM), is an enzyme replacement therapy for the treatment of nonneurologic manifestations of acid sphingomyelinase deficiency (ASMD). This ongoing, open-label, long-term study (NCT02004704) assessed safety and efficacy of olipudase alfa following 30 months of treatment in five adult patients with ASMD. There were no deaths, serious or severe events, or discontinuations during 30 months of treatment. The majority of adverse events were mild and included headache, nausea, and abdominal pain...
January 5, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29302215/inhibitory-effects-of-2-6-di-tert-butyl-4-hydroxymethylphenol-on-asthmatic-responses-to-ovalbumin-challenge-in-conscious-guinea-pigs
#20
Seul-Yong Jeong, Ji-Yun Lee
This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining the specific airway resistance (sRaw) and tidal volume (TV) during the immediate asthmatic response (IAR) and the late-phase asthmatic response (LAR) in guinea pigs with aerosolized ovalbumin-induced asthma. Recruitment of leukocytes and the levels of biochemical inflammatory mediators were determined in the bronchoalveolar lavage fluids (BALFs), and histopathological surveys performed in lung tissues...
January 2018: Korean Journal of Physiology & Pharmacology
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