keyword
MENU ▼
Read by QxMD icon Read
search

Chang Lung Ji

keyword
https://www.readbyqxmd.com/read/28320428/a-topology-based-method-to-mitigate-the-dosimetric-uncertainty-caused-by-the-positional-variation-of-the-boost-volume-in-breast-conservative-radiotherapy
#1
Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien, Chun-Nan Chu, Hsiu-Ting Hsu, Ji-An Liang, Ying-Jun Lin, An-Cheng Shiau
BACKGROUND: To improve local control rate in patients with breast cancer receiving adjuvant radiotherapy after breast conservative surgery, additional boost dose to the tumor bed could be delivered simultaneously via the simultaneous integrated boost (SIB) modulated technique. However, the position of tumor bed kept changing during the treatment course as the treatment position was aligned to bony anatomy. This study aimed to analyze the positional uncertainties between bony anatomy and tumor bed, and a topology-based approach was derived to stratify patients with high variation in tumor bed localization...
March 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28319809/abt-737-synergizes-with-cisplatin-bypassing-aberration-of-apoptotic-pathway-in-non-small-cell-lung-cancer
#2
Eun Young Kim, Ji Ye Jung, Arum Kim, Yoon Soo Chang, Se Kyu Kim
A subset of non-small cell lung cancer (NSCLC), which does not have a druggable driver mutation, is treated with platinum-based cytotoxic chemotherapy, but it develops resistance triggered by DNA damage responses. Here, we investigated the effect of activation of STAT3 by cisplatin on anti-apoptotic proteins and the effectiveness of a co-treatment with cisplatin and a BH3 mimetic, ABT-737. We analyzed the relationship between cisplatin and STAT3 pathway and effect of ABT-737, when combined with cisplatin in NSCLC cells and K-ras mutant mouse models...
March 17, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28301223/antitumor-effect-of-nanoparticle-131-i-labeled-arginine-glycine-aspartate-bovine-serum-albumin-polycaprolactone-in-lung-cancer
#3
Hui Ming, Lei Fang, Jingmei Gao, Chengxia Li, Yanhui Ji, Yiming Shen, Yiming Hu, Ning Li, Jin Chang, Wei Li, Jian Tan
OBJECTIVE: The aim of the present study is to investigate the biologic effects of internal irradiation and the therapeutic effectiveness of (131)I-labeled arginine-glycine-aspartate (RGD)-bovine serum albumin (BSA)-polycaprolactone (PCL) ((131)I-RGD-BSA-PCL) in murine lung cancer models. MATERIALS AND METHODS: The target binding and cellular uptake of NCI-H460 lung cancer cells overexpressing integrin αvβ3 were observed by confocal microscopy. Flow cytometry was used to assay apoptosis...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28299842/electroacupuncture-promotes-cns-dependent-release-of-mesenchymal-stem-cells
#4
Tatiana E Salazar, Matthew R Richardson, Eleni Beli, Matthew S Ripsch, John George, Youngsook Kim, Yaqian Duan, Leni Moldovan, Yuanqing Yan, Ashay Bhatwadekar, Vaishnavi Jadhav, Jared A Smith, Susan McGorray, Alicia L Bertone, Dmitri O Traktuev, Keith L March, Luis M Colon-Perez, Keith Avin, Emily Sims, Julie A Mund, Jamie Case, Shaolin Deng, Min Su Kim, Bruce McDavitt, Michael E Boulton, Jeffrey Thinschmidt, Sergio Li Calzi, Stephanie D Fitz, Robyn K Fuchs, Stuart J Warden, Todd McKinley, Anantha Shekhar, Marcelo Febo, Phillip L Johnson, Lung Ji Chang, Zhanguo Gao, Mikhail G Kolonin, Song Lai, Jinfeng Ma, Xinzhong Dong, Fletcher A White, Huisheng Xie, Mervin C Yoder, Maria B Grant
Electro-acupuncture (EA) performed in rats and humans using front-limb acupuncture sites, LI-4 and LI-11, and Du-14 and Du-20 increased functional connectivity between the anterior hypothalamus and the amygdala and mobilized mesenchymal stem cells (MSC) into the systemic circulation. In human subjects, the source of the MSC was found to be primarily adipose tissue whereas in rodents the tissue sources were considered more heterogeneous. Pharmacological disinhibition of rat hypothalamus enhanced sympathetic nervous system (SNS) activation and similarly resulted in a release of MSC into the circulation...
March 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28294434/immunologic-regulatory-effects-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-in-a-murine-ovalbumin-asthma-model
#5
Sung-Yoon Kang, Da-Eun Park, Woo-Jung Song, Bo-Ram Bae, Ji-Won Lee, Kyoung-Hee Sohn, Hyun-Seung Lee, Hye-Ryun Kang, Heung-Woo Park, Yoon-Seok Chang, Soo-Jin Choi, Won-Il Oh, Kyung-Up Min, Sang-Heon Cho
BACKGROUND: Mesenchymal stem cells (MSCs) have multiple immunomodulatory properties and hold therapeutic potential for inflammatory diseases. However, the therapeutic and immunologic effects of human umbilical cord blood-derived MSCs (huMSCs) remain largely unexamined for asthma. OBJECTIVE: This study was to investigate the immunomodulatory properties of huMSCs in an ovalbumin (OVA)-induced murine asthma model. METHODS: Mice were injected intraperitoneally with OVA and an aluminum hydroxide adjuvant...
March 14, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28280409/paracrine-influence-of-human-perivascular-cells-on-the-proliferation-of-adenocarcinoma-alveolar-epithelial-cells
#6
Eunbi Kim, Sunghun Na, Borim An, Se-Ran Yang, Woo Jin Kim, Kwon-Soo Ha, Eun-Taek Han, Won Sun Park, Chang-Min Lee, Ji Yoon Lee, Seung-Joon Lee, Seok-Ho Hong
Understanding the crosstalk mechanisms between perivascular cells (PVCs) and cancer cells might be beneficial in preventing cancer development and metastasis. In this study, we investigated the paracrine influence of PVCs derived from human umbilical cords on the proliferation of lung adenocarcinoma epithelial cells (A549) and erythroleukemia cells (TF-1α and K562) in vitro using Transwell® co-culture systems. PVCs promoted the proliferation of A549 cells without inducing morphological changes, but had no effect on the proliferation of TF-1α and K562 cells...
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28272300/a-human-antibody-that-binds-to-the-sixth-ig-like-domain-of-vcam-1-blocks-lung-cancer-cell-migration-in-vitro
#7
Mi Ra Kim, Ji Hye Jang, Chang Sik Park, Taek-Keun Kim, Youn-Jae Kim, Junho Chung, Hyunbo Shim, In Hyun Nam, Jung Min Han, Sukmook Lee
Vascular cell adhesion molecule-1 (VCAM-1) is closely associated with tumor progression and metastasis. However, the relevance and role of VCAM-1 in lung cancer have not been clearly elucidated. In this study, we found that VCAM-1 was highly overexpressed in lung cancer tissue compared with that of normal lung tissue, and high VCAM-1 expression correlated with poor survival in lung cancer patients. VCAM-1 knockdown reduced migration of A549 human lung cancer cells into Matrigel, and competitive blocking experiments targeting the Ig-like domain 6 of VCAM-1 (VCAM-1-D6) demonstrated that the VCAM-1-D6 domain was critical for VCAM-1 mediated A549 cell migration into Matrigel...
March 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28260071/axl-and-met-receptor-tyrosine-kinases-are-essential-for-lung-cancer-metastasis
#8
Yun Jung Choi, Ji Hye Kim, Jin Kyung Rho, Joong Sun Kim, Chang-Min Choi, Woo Sung Kim, Jaekyoung Son, Jae Cheol Lee
The AXL and MET receptors regulate key processes in tumor growth, metastasis, and drug resistance; thus, they have recently been implicated as promising therapeutic targets in various tumors. We investigated the metastatic potential and crosstalk between these receptors in non‑small cell lung cancer (NSCLC). We found that the treatment of NSCLC cells with hepatocyte growth factor (HGF) and growth arrest-specific 6 (Gas6), as ligands for MET and AXL, respectively, promoted their migration and invasion ability...
March 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28241696/-changes-of-the-expression-for-genes-related-with-senescence-and-the-telomerase-activity-during-cellular-replicative-and-premature-senescence-in-human-embryonic-lung-fibroblasts
#9
J P Yang, W J Zhang, C X Jing, C P Wu, W D Ji, L Q Yang, Z X Zhuang
Objective: To detect the alterations of telomerase activity and the expression for oxidative stress responsive genes related with senescence during cellular replicative senescence and hydrogen peroxide-induced premature senescence in human embryonic lung fibroblasts (HELFs) in vitro. Methods: The HELFs were divided into young cells (22 population doubling levels, 22PDL) , mid-aged cells (35PDL) and replicative senes-cent cells (49PDL) and premature senescent cells induced by H(2)O(2)(premature senescence, PS)...
January 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28236539/individual-case-review-in-a-phase-3-randomized-trial-to-investigate-the-role-of-internal-mammary-lymph-node-irradiation-for-breast-cancer-korean-radiation-oncology-group-08-06-study
#10
Hong In Yoon, Jeongmin Yoon, Yoonsun Chung, Chung Mo Nam, Hyejung Cha, Jinhyun Choi, Jeongshim Lee, Hee Ji Han, Yeona Cho, Yong Bae Kim, Chang-Ok Suh
PURPOSE/OBJECTIVE: This study aimed to assess protocol compliance based on an individual case review (ICR) of the Korean Radiation Oncology Group-0806 trial. METHODS AND MATERIALS: For the ICR, 747 participants were divided into eight subgroups based on internal mammary node irradiation (IMNI), tumor laterality, and surgery type. Next, 15% of patients were randomly selected within each subgroup, and corresponding hospitals were subsequently requested to upload information related to radiation therapy (RT) planning...
February 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28228162/efficacy-and-safety-of-indacaterol-glycopyrronium-fixed-dose-combination-in-mild-to-moderate-copd-patients-symptomatic-on-tiotropium-in-korea-study-protocol-for-a-randomized-controlled-trial
#11
Chin Kook Rhee, Hye Yun Park, Jeong-Woong Park, Ji-Hyun Lee, Tae-Hyung Kim, Sei Won Lee, Ji Ye Jung, Song Kim, Yong Il Hwang, Ki-Suck Jung
BACKGROUND: Long-acting bronchodilator monotherapy (long-acting β2-agonist [LABA] or long-acting muscarinic antagonist [LAMA]) is extensively used for treatment of patients with chronic obstructive pulmonary disease (COPD) with mild-to-moderate airflow limitation. However, a substantial number of patients remain symptomatic despite treatment with a single bronchodilator, necessitating a change in therapy. METHODS: This 12-week, randomized, multicenter, open-label, phase IV study aims to show that the once-daily indacaterol/glycopyrronium (IND/GLY) 110/50 μg fixed-dose LABA/LAMA combination results in an improved lung function in symptomatic patients with mild-to-moderate COPD who switch from once-daily tiotropium 18 μg...
February 22, 2017: Trials
https://www.readbyqxmd.com/read/28209923/novel-involvement-of-rhebl1-in-sphingosylphosphorylcholine-induced-keratin-phosphorylation-and-reorganization-binding-to-and-activation-of-akt1
#12
Hyun Ji Kim, Hyun Jung Byun, Mi Kyung Park, Eun Ji Kim, Gyeoung Jin Kang, Chang Hoon Lee
Sphingosylphosphorylcholine induces keratin phosphorylation and reorganization, and increases viscoelasticity of metastatic cancer cells such as PANC-1 cells. However, the mechanism involved in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization is largely unknown. Sphingosylphosphorylcholine dose- and time-dependently induces the expression of RhebL1. The involvement of RhebL1 in sphingosylphosphorylcholine-induced events including keratin 8 (K8) phosphorylation, reorganization, migration and invasion was examined...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28202896/effect-of-mild-hypercapnia-on-lung-oxygenation-in-sitting-position-during-shoulder-arthroscopy-under-general-anesthesia
#13
Hyun Jeong Kwak, Ji Yeon Lee, Jong Wha Lee, Hong Soon Kim, Ho Jin Hur, Ji Young Kim
BACKGROUND Mild hypercapnia is permitted during surgeries in sitting position under general anesthesia to maintain cerebral regional oxygen saturation (rSO2). However, since hypoventilation may cause gas exchange impairment, we evaluated effects of mild hypercapnia on lung oxygenation during shoulder arthroscopy in sitting position. MATERIAL AND METHODS Forty patients were randomly allocated to a normocapnia group (ETCO2 35 mmHg, n=20) or a hypercapnia group (45 mmHg, n=20). The mean arterial pressure (MAP), heart rate (HR), and rSO2 were measured 5 min after intubation in supine position (T0), and at 2, 4, 6, 8, 10, 20, 30, 40, 50, and 60 min of remaining in sitting position (T1-10)...
February 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28202390/systemic-injection-of-rpe65-programmed-bone-marrow-derived-cells-prevents-progression-of-chronic-retinal-degeneration
#14
Xiaoping Qi, S Louise Pay, Yuanqing Yan, James Thomas, Alfred S Lewin, Lung-Ji Chang, Maria B Grant, Michael E Boulton
Bone marrow stem and progenitor cells can differentiate into a range of non-hematopoietic cell types, including retinal pigment epithelium (RPE)-like cells. In this study, we programmed bone marrow-derived cells (BMDCs) ex vivo by inserting a stable RPE65 transgene using a lentiviral vector. We tested the efficacy of systemically administered RPE65-programmed BMDCs to prevent visual loss in the superoxide dismutase 2 knockdown (Sod2 KD) mouse model of age-related macular degeneration. Here, we present evidence that these RPE65-programmed BMDCs are recruited to the subretinal space, where they repopulate the RPE layer, preserve the photoreceptor layer, retain the thickness of the neural retina, reduce lipofuscin granule formation, and suppress microgliosis...
February 12, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28202030/upregulation-of-interleukin-33-and-thymic-stromal-lymphopoietin-levels-in-the-lungs-of-idiopathic-pulmonary-fibrosis
#15
Jong-Uk Lee, Hun Soo Chang, Hyeon Ju Lee, Chang An Jung, Da Jeong Bae, Hyun Ji Song, Jong Sook Park, Soo-Taek Uh, Young Hoon Kim, Ki-Hyun Seo, Choon-Sik Park
BACKGROUND: Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. METHODS: TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal controls (NCs; n = 40) and from patients with idiopathic pulmonary fibrosis (IPF; n = 100), non-specific interstitial pneumonia (NSIP; n = 22), hypersensitivity pneumonitis (HP; n = 20), and sarcoidosis (n = 19)...
February 15, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28177603/pro-inflammatory-and-pro-fibrogenic-effects-of-ionic-and-particulate-arsenide-and-indium-containing-semiconductor-materials-in-the-murine-lung
#16
Wen Jiang, Xiang Wang, Olivia J Osborne, Yingjie Du, Chong Hyun Chang, Yu-Pei Liao, Bingbing Sun, Jinhong Jiang, Zhaoxia Ji, Ruibin Li, Xiangsheng Liu, Jianqin Lu, Sijie Lin, Huan Meng, Tian Xia, André E Nel
We have recently shown that the toxicological potential of GaAs and InAs particulates in cells is size- and dissolution-dependent, tending to be more pronounced for nano- vs micron-sized particles. Whether the size-dependent dissolution and shedding of ionic III-V materials also apply to pulmonary exposure is unclear. While it has been demonstrated that micron-sized III-V particles, such as GaAs and InAs, are capable of inducing hazardous pulmonary effects in an occupational setting as well as in animal studies, the effect of submicron particles (e...
February 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28134325/basophil-derived-il-6-regulates-th17-cell-differentiation-and-cd4-t-cell-immunity
#17
Chae Min Yuk, Hyeung Ju Park, Bo-In Kwon, Sang Joon Lah, Jun Chang, Ji-Young Kim, Kyung-Mi Lee, Su-Hyung Park, Seokchan Hong, Seung-Hyo Lee
Basophils are rare, circulating granulocytes proposed to be involved in T helper (TH) type 2 immunity, mainly through secretion of interleukin (IL)-4. In addition to IL-4, basophils produce IL-6 and tumor necrosis factor (TNF)-α in response to immunoglobulin E (IgE) crosslinking. Differentiation of TH17 cells requires IL-6 and transforming growth factor (TGF)-β, but whether basophils play a significant role in TH17 induction is unknown. Here we show a role for basophils in TH17 cell development by using in vitro T cell differentiation and in vivo TH17-mediated inflammation models...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28131636/superior-treatment-response-and-in-field-tumor-control-in-epidermal-growth-factor-receptor-mutant-genotype-of-stage-iii-nonsquamous-non-small-cell-lung-cancer-undergoing-definitive-concurrent-chemoradiotherapy
#18
Yu Jin Lim, Ji Hyun Chang, Hak-Jae Kim, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Jin Chul Paeng, Keon Wook Kang, June-Key Chung, Yoon Kyung Jeon, Doo Hyun Chung, Hong-Gyun Wu
BACKGROUND: Although previous in vitro data have suggested a more radio-sensitive nature of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) cell lines, the clinical behavior according to the EGFR mutational status has not been well-established. In this study, we performed a comparative outcome analysis of EGFR-mutant and wild-type locally advanced NSCLC with chemoradiotherapy (CRT). PATIENTS AND METHODS: A total of 102 patients with stage III nonsquamous NSCLC undergoing primary CRT were identified...
December 28, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28123567/inhibitory-effect-of-dexamethasone-on-residual-lewis-lung-cancer-cells-in-mice-following-palliative-surgery
#19
Ningbo Sun, Huaijun Ji, Wei Wang, Qiang Zhu, Ming Cao, Qi Zang
Previous studies found that glucocorticoids were closely associated with the oncogenesis and development of numerous types of tumors. The aim of the present study was to investigate the effect of dexamethasone on the growth and angiogenesis of Lewis lung cancer cells in mice who received palliative surgery. Lewis lung carcinoma cells were inoculated subcutaneously into the right axilla of C57BL/6 mice. When tumor diameter reached 0.5 cm, 2 weeks later, palliative surgery was performed, and the mice were randomly divided into 3 groups with 6 animals in each group (control group, cisplatin group and dexamethasone group)...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28107868/effect-of-ppar%C3%AE-agonist-rosiglitazone-on-the-secretion-of-th2-cytokine-in-asthma-mice
#20
Ji-Hui Yu, Li Long, Zhi-Xiao Luo, Jie-Ru You
OBJECTIVE: To explore the effect of PPARγ agonist (rosiglitazone) on the secretion of Th2 cytokines and the proportion of immune cell subsets in asthma mice. METHODS: Ovalbumin (OVA)-sensitized mice were used to build asthma models. Those mice were divided into the normal control group, model group and rosiglitazone group. Differences of the changes in lung histopathology of mice in the three groups were observed through hematoxylin and eosin (HE) strain, and the numbers of the total cells, eosinophils and neutrophils in BALF of mice in the three groups were compared...
January 2017: Asian Pacific Journal of Tropical Medicine
keyword
keyword
81087
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"