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Chang Lung Ji

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https://www.readbyqxmd.com/read/27895424/irf5-regulates-lung-macrophages-m2-polarization-during-severe-acute-pancreatitis-in-vitro
#1
Kang Sun, Song-Bing He, Jian-Guo Qu, Sheng-Chun Dang, Ji-Xiang Chen, Ai-Hua Gong, Rong Xie, Jian-Xin Zhang
AIM: To investigate the role of interferon regulatory factor 5 (IRF5) in reversing polarization of lung macrophages during severe acute pancreatitis (SAP) in vitro. METHODS: A mouse SAP model was established by intraperitoneal (ip) injections of 20 μg/kg body weight caerulein. Pathological changes in the lung were observed by hematoxylin and eosin staining. Lung macrophages were isolated from bronchoalveolar lavage fluid. The quantity and purity of lung macrophages were detected by fluorescence-activated cell sorting and evaluated by real-time polymerase chain reaction (RT-PCR)...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27882349/the-airway-epithelium-undergoes-metabolic-reprogramming-in-individuals-at-high-risk-for-lung-cancer
#2
S M Jamshedur Rahman, Xiangming Ji, Lisa J Zimmerman, Ming Li, Bradford K Harris, Megan D Hoeksema, Irina A Trenary, Yong Zou, Jun Qian, Robbert J C Slebos, Jennifer Beane, Avrum Spira, Yu Shyr, Rosana Eisenberg, Daniel C Liebler, Jamey D Young, Pierre P Massion
The molecular determinants of lung cancer risk remain largely unknown. Airway epithelial cells are prone to assault by risk factors and are considered to be the primary cell type involved in the field of cancerization. To investigate risk-associated changes in the bronchial epithelium proteome that may offer new insights into the molecular pathogenesis of lung cancer, proteins were identified in the airway epithelial cells of bronchial brushing specimens from risk-stratified individuals by shotgun proteomics...
November 17, 2016: JCI Insight
https://www.readbyqxmd.com/read/27873490/egf-induced-ret-inhibitor-resistance-in-ccdc6-ret-lung-cancer-cells
#3
Hyun Chang, Ji Hea Sung, Sung Ung Moon, Han Soo Kim, Jin Won Kim, Jong Seok Lee
PURPOSE: Rearrangement of the proto-oncogene rearranged during transfection (RET) has been newly identified potential driver mutation in lung adenocarcinoma. Clinically available tyrosine kinase inhibitors (TKIs) target RET kinase activity, which suggests that patients with RET fusion genes may be treatable with a kinase inhibitor. Nevertheless, the mechanisms of resistance to these agents remain largely unknown. Thus, the present study aimed to determine whether epidermal growth factor (EGF) and hepatocyte growth factor (HGF) trigger RET inhibitor resistance in LC-2/ad cells with CCDC6-RET fusion genes...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27864285/il-23-secreted-by-bronchial-epithelial-cells-contributes-allergic-sensitization-in-asthma-model
#4
Hyun Seung Lee, Da-Eun Park, Ji-Won Lee, Yuna Chang, Hye Young Kim, Woo-Jung Song, Hye-Ryun Kang, Heung-Woo Park, Yoon-Seok Chang, Sang-Heon Cho
BACKGROUND: IL-23 has been postulated to be a critical mediator contributing to various inflammatory diseases. Dermatophagoides pteronyssinus (Der p) is one of the most common inhalant allergens. However, the role of IL-23 in Der p-induced mouse asthma model is not well understood, particularly with regard to the development of allergic sensitization in the airways. OBJECTIVE: To evaluate roles of IL-23 in Der p-sensitization and asthma development. METHODS: BALB/c mice were repeatedly administered with Der p intra-nasally to develop Der p-allergic sensitization and asthma...
November 18, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27861375/trends-of-do-not-resuscitate-consent-and-hospice-care-utilization-among-noncancer-decedents-in-a-tertiary-hospital-in-taiwan-between-2010-and-2014-a-hospital-based-observational-study
#5
Hsiao-Ting Chang, Ming-Hwai Lin, Chun-Ku Chen, Pesus Chou, Tzeng-Ji Chen, Shinn-Jang Hwang
Do-Not-Resuscitate (DNR) and hospice care are not only applied to cancer patients but also to patients with noncancer progressive illness. However, the trends of DNR consent and hospice utilization are not well explored for noncancer patients. This study aimed to explore the trends of DNR consent and hospice care utilization among noncancer decedents in a tertiary hospital in Taiwan. We analyzed the Death and Hospice Palliative Care Database from the Taipei Veterans General Hospital in Taiwan. The Death and Hospice Palliative Care Database contains information including patient sex, major diagnosis, admission date, date of death, age at death, department at discharge, status of DNR consent, and status of hospice care of patients who died in the Taipei Veterans General Hospital...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27845421/rs2735383-located-at-a-microrna-binding-site-in-the-3-utr-of-nbs1-is-not-associated-with-breast-cancer-risk
#6
Jingjing Liu, Ivona Lončar, J Margriet Collée, Manjeet K Bolla, Joe Dennis, Kyriaki Michailidou, Qin Wang, Irene L Andrulis, Monica Barile, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Carl Blomqvist, Bram Boeckx, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Jenny Chang-Claude, Shou-Tung Chen, Georgia Chenevix-Trench, Ching Y Cheng, Ji-Yeob Choi, Fergus J Couch, Angela Cox, Simon S Cross, Katarina Cuk, Kamila Czene, Thilo Dörk, Isabel Dos-Santos-Silva, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Graham G Giles, Gord Glendon, Mark S Goldberg, Anna González-Neira, Pascal Guénel, Christopher A Haiman, Ute Hamann, Steven N Hart, Mikael Hartman, Sigrid Hatse, John L Hopper, Hidemi Ito, Anna Jakubowska, Maria Kabisch, Daehee Kang, Veli-Matti Kosma, Vessela N Kristensen, Loic Le Marchand, Eunjung Lee, Jingmei Li, Artitaya Lophatananon, Jan Lubinski, Arto Mannermaa, Keitaro Matsuo, Roger L Milne, Susan L Neuhausen, Heli Nevanlinna, Nick Orr, Jose I A Perez, Julian Peto, Thomas C Putti, Katri Pylkäs, Paolo Radice, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Andreas Schneeweiss, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Jacques Simard, Melissa C Southey, Anthony Swerdlow, Soo H Teo, Daniel C Tessier, Somchai Thanasitthichai, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-Chen Tseng, Celine Vachon, Robert Winqvist, Anna H Wu, Drakoulis Yannoukakos, Wei Zheng, Per Hall, Alison M Dunning, Douglas F Easton, Maartje J Hooning, Ans M W van den Ouweland, John W M Martens, Antoinette Hollestelle
NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27836576/establishment-of-a-conditional-transgenic-mouse-model-recapitulating-eml4-alk-positive-human-non-small-cell-lung-cancer
#7
Kyoung Ho Pyo, Sun Min Lim, Hye Ryun Kim, Young Hoon Sung, Mi Ran Yun, Sung-Moo Kim, Hwan Kim, Han Na Kang, Ji Min Lee, Sang Gyun Kim, Chae Won Park, Hyun Chang, Hyo Sup Shim, Han-Woong Lee, Byoung Chul Cho
BACKGROUND: ALK fusion is a distinct molecular subclassification of non-small-cell lung cancer (NSCLC) that is targeted by ALK inhibitors. We established a transgenic mouse model that expresses tumors highly resembling human NSCLC harboring EML-ALK fusion. We aimed to test EML4-ALK transgenic mouse model as a platform for assessing efficacy of ALK inhibitor and examining mechanisms of acquired resistance to ALK inhibitor. MATERIALS AND METHODS: Transgenic mouse lines harboring LoxP-STOP-LoxP- FLAG tagged human EML4-ALK (variant 1) transgene was established using C57BL/6N mice...
November 8, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27835790/the-p38%C3%AE-rs3804451-variant-predicts-chemotherapy-response-and-survival-of-patients-with-non-small-cell-lung-cancer-treated-with-platinum-based-chemotherapy
#8
Ming Jia, Yuan Xu, Meiling Zhu, Mengyun Wang, Menghong Sun, Ji Qian, Jianhua Chang, Qingyi Wei
The JNK and P38α pathways play an important role in the sensitivity and outcomes of chemotherapy. We hypothesize that functional single nucleotide polymorphisms (SNPs) of genes of these pathways modulate outcomes of patients with advanced non-small cell lung cancer (NSCLC) treated with first-line platinum-based chemotherapy (PBC). We selectively genotyped 11 independent, potentially functional SNPs of 9 genes in the JNK and P38α pathways first in a discovery group of 355 patients with advanced NSCLC treated with PBC, and we evaluated their associations with progression-free survival (PFS) and overall survival (OS) by Cox proportional hazards regression analysis...
November 8, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27821246/erratum-to-effect-of-roflumilast-novel-phosphodiesterase-4-inhibitor-on-lung-chronic-graft-versus-host-disease-in-mice
#9
Sei Won Kim, Ji Young Lim, Chin Kook Rhee, Ji Hye Kim, Chan Kwon Park, Tae Jung Kim, Chul Soo Cho, Chang Ki Min, Hyoung Kyu Yoon
No abstract text is available yet for this article.
November 4, 2016: Experimental Hematology
https://www.readbyqxmd.com/read/27817168/knockdown-of-dixdc1-inhibits-the-proliferation-and-migration-of-human-glioma-cells
#10
Jianguo Chen, Chaoyan Shen, Jinlong Shi, Jianhong Shen, Wenjuan Chen, Jie Sun, Shaocheng Fan, Yuanqi Bei, Peng Xu, Hao Chang, Rui Jiang, Lu Hua, Bin Ji, Qingfeng Huang
DIX domain containing 1 (DIXDC1), the human homolog of coiled-coil-DIX1 (Ccd1), is a positive regulator of Wnt signaling pathway. Recently, it was found to act as a candidate oncogene in colon cancer, non-small-cell lung cancer, and gastric cancer. In this study, we aimed to investigate the clinical significance of DIXDC1 expression in human glioma and its biological function in glioma cells. Western blot and immunohistochemistry analysis showed that DIXDC1 was overexpressed in glioma tissues and glioma cell lines...
November 5, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27809459/survey-of-the-patterns-of-using-stereotactic-ablative-radiotherapy-for-early-stage-non-small-cell-lung-cancer-in-korea
#11
Sanghyuk Song, Ji Hyun Chang, Hak Jae Kim, Yeon Sil Kim, Jin Hee Kim, Yong Chan Ahn, Jae-Sung Kim, Si Yeol Song, Sung Ho Moon, Moon June Cho, Seon Min Youn
Purpose: Stereotactic ablative radiotherapy (SABR) is an effective emerging technique for early-stage non-small cell lung cancer (NSCLC). We investigated the current practice of SABR for early-stage NSCLC in Korea. Materials and Methods: We conducted a nationwide survey of SABR for NSCLC by sending e-mails to all board-certified members of the Korean Society for Radiation Oncology. The survey included 23 questions focusing on the technical aspects of SABR and 18 questions seeking the participants' opinions on specific clinical scenarios in the use of SABR for early-stage NSCLC...
October 31, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27806330/plasma-glutamate-carboxypeptidase-is-a-negative-regulator-in-liver-cancer-metastasis
#12
Jae-Hye Lee, Hyun-Soo Cho, Jeong-Ju Lee, Soo Young Jun, Jun-Ho Ahn, Ju-Sik Min, Ji-Yong Yoon, Min-Hyuk Choi, Su-Jin Jeon, Jung Hwa Lim, Cho-Rok Jung, Dae-Soo Kim, Hyun-Taek Kim, Valentina M Factor, Yun-Han Lee, Snorri S Thorgeirsson, Cheol-Hee Kim, Nam-Soon Kim
Tumor metastasis is the leading cause of cancer death. In the metastatic process, EMT is a unique phenotypic change that plays an important role in cell invasion and changes in cell morphology. Despite the clinical significance, the mechanism underlying tumor metastasis is still poorly understood. Here we report a novel mechanism by which secreted plasma glutamate carboxypeptidase(PGCP) negatively involves Wnt/β-catenin signaling by DKK4 regulation in liver cancer metastasis. Pathway analysis of the RNA sequencing data showed that PGCP knockdown in liver cancer cell lines enriched the functions of cell migration, motility and mesenchymal cell differentiation...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27805311/differences-in-chronic-obstructive-pulmonary-disease-phenotypes-between-non-smokers-and-smokers
#13
Wonjun Ji, Myoung Nam Lim, So Hyeon Bak, Seok-Ho Hong, Seon-Sook Han, Seung-Joon Lee, Woo Jin Kim, Yoonki Hong
INTRODUCTION AND OBJECTIVES: Although tobacco smoking is a major risk factor for chronic obstructive pulmonary disease (COPD), more than one-fourth of COPD patients are non-smokers. In this cross-sectional study, the differences in COPD phenotypes between non-smokers and smokers in male subjects were investigated and were focused on structural lung changes using a quantitative assessment of computed tomography (CT) images. METHODS: They divided male participants with COPD, from a Korean cohort near a cement plant, into non-smokers and smokers by a cutoff of a 5 pack-year smoking history...
November 2, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27802778/transplantation-of-adipose-tissue-derived-mesenchymal-stem-cell-atmsc-expressing-alpha-1-antitrypsin-reduces-bone-loss-in-ovariectomized-osteoporosis-mice
#14
Mohammad Ahsanul Akbar, Yuanqing Lu, Ahmed S Elshikha, Mong-Jen Chen, Yuan Ye, Elizabeth M Whitley, Lexie Shannon Holliday, Chang Lung-Ji, Sihong Song
Osteoporosis is a common health problem severely affecting the life quality of many people, especially women. Current treatment options for osteoporosis are limited due to their association with several side-effects and moderate efficacy. Therefore, novel therapies for osteoporosis are needed. In this study, we tested the feasibility of adipose tissue-derived mesenchymal stem cell (ATMSC) based human AAT (hAAT) gene therapy for the prevention of bone loss in an ovariectomized (OVX) mouse model. Eight-week-old female C57BL6 mice underwent ovariectomy and treated with hAAT (protein therapy), ATMSC (stem cell therapy), ATMSC+hAAT (combination of ATMSC and hAAT therapy), ATMSCs infected with lentiviral vectors expressing hAAT (ATMSC based hAAT gene therapy)...
November 1, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27802588/gene-profiles-in-a-smoke-induced-copd-mouse-lung-model-following-treatment-with-mesenchymal-stem-cells
#15
You-Sun Kim, Nurdan Kokturk, Ji-Young Kim, Sei Won Lee, Jaeyun Lim, Soo Jin Choi, Wonil Oh, Yeon-Mok Oh
Mesenchymal stem cells (MSCs) effectively reduce airway inflammation and regenerate the alveolus in cigarette- and elastase-induced chronic obstructive pulmonary disease (COPD) animal models. The effects of stem cells are thought to be paracrine and immune-modulatory because very few stem cells remain in the lung one day after their systemic injection, which has been demonstrated previously. In this report, we analyzed the gene expression profiles to compare mouse lungs with chronic exposure to cigarette smoke with non-exposed lungs...
October 2016: Molecules and Cells
https://www.readbyqxmd.com/read/27799678/differences-in-respirogram-phase-between-taekwondo-poomsae-athletes-and-nonathletes
#16
Yong-Sub Shin, Seung-Min Yang, Mee-Young Kim, Lim-Kyu Lee, Byoung-Sun Park, Won-Deok Lee, Ji-Woong Noh, Ju-Hyun Kim, Jeong-Uk Lee, Taek-Yong Kwak, Tae-Hyun Lee, Jaehong Park, Junghwan Kim
[Purpose] Respiratory physiotherapy is an effective approach to improving lung function in patient, including athletes with respiratory dysfunction caused by sports injury. The purpose of this study was to analyze the differences in the respirograms between taekwondo poomsae athletes and nonathletes according to the respirogram phase. [Subjects and Methods] Respiratory measurements for 13 elite taekwondo poomsae athletes were obtained. Respiratory function was measured using spirometry while the participant was seated...
September 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27793026/dynamic-prognostication-using-conditional-survival-analysis-for-patients-with-operable-lung-adenocarcinoma
#17
Wooil Kim, Ho Yun Lee, Sin-Ho Jung, Min-Ah Woo, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Joungho Han, Ji Yun Jeong, Joon Young Choi, Kyung Soo Lee
PURPOSE: To evaluate conditional survival among patients with surgically resected stage I-IIIa lung adenocarcinoma and identify changes in prognostic contributions for various prognostic factors over time. PATIENTS AND METHODS: We performed conditional survival analysis at each t0 (=0, 1, 2, 3, 4, 5 years) for 723 consecutive patients who underwent surgical resection for lung adenocarcinoma, stratified by various clinico-demographic features, as well as pathologic and imaging (tumor-shadow disappearance ratio [TDR] on CT and maximum standardized uptake value [SUVmax] on PET) characteristics...
October 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27784331/lung-ultrasound-a-promising-tool-to-monitor-ventilator-associated-pneumonia-in-critically-ill-patients
#18
REVIEW
Guyi Wang, Xiaoying Ji, Yongshan Xu, Xudong Xiang
Ventilator-associated pneumonia (VAP) is the most frequent intensive care unit (ICU)-acquired infection that is independently associated with mortality. Accurate diagnosis and timely treatment have been shown to improve the prognosis of VAP. Chest X-ray or computed tomography imaging are used for conventional assessment of VAP, but these methods are impractical for real-time measurement in critical patients. Therefore, lung ultrasound (LUS) has been increasingly used for the assessment of VAP in the ICU. Traditionally, LUS has seemed unsuitable for the detection of lung parenchyma owing to the high acoustic impedance of air; however, the fact that the reflection and reverberation in the detection region of the ultrasound reflect the underlying pathology of lung diseases has led to the increased use of ultrasound imaging as a standard of care supported by evidence-based and expert consensus in the ICU...
October 27, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27768973/non-invasive-visualization-of-mast-cell-recruitment-and-its-effects-in-lung-cancer-by-optical-reporter-gene-imaging-and-glucose-metabolism-monitoring
#19
Seul-Gi Oh, Xian Li, Ho Won Lee, Thoudam Debraj Singh, Sang Bong Lee, Hyun Dong Ji, GhilSuk Yoon, Sung Jin Cho, In-Kyu Lee, Shin Young Jeong, Byeong-Cheol Ahn, Jaetae Lee, Hyeun Wook Chang, Sang-Woo Lee, Yong Hyun Jeon
The inability to monitor the in vivo dynamics of mast cells (MCs) limits the better understanding of its role in cancer progression. Here, we report on noninvasive imaging of MC migration to tumor lesions in mice and evaluation of the effects of migrated MCs on tumor progression through reporter gene-based in vivo optical imaging and glucose metabolism monitoring in cancer with (18)F-fluorodeoxyglucose ((18)F-FDG) in vitro and in vivo. Murine MCs (MC-9) and Lewis lung cancer cells (LLC) expressing an enhanced firefly luciferase (effluc) gene were established, termed MC-9/effluc and LLC/effluc, respectively...
October 13, 2016: Biomaterials
https://www.readbyqxmd.com/read/27767175/genetic-polymorphisms-in-glycolytic-pathway-are-associated-with-the-prognosis-of-patients-with-early-stage-non-small-cell-lung-cancer
#20
Shin Yup Lee, Cheng Cheng Jin, Jin Eun Choi, Mi Jeong Hong, Deuk Kju Jung, Sook Kyung Do, Sun Ah Baek, Hyo Jung Kang, Hyo-Gyoung Kang, Sun Ha Choi, Won Kee Lee, Yangki Seok, Eung Bae Lee, Ji Yun Jeong, Kyung Min Shin, Sukki Cho, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, You Mie Lee, In-Kyu Lee, Sanghoon Jheon, Jae Yong Park
This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Forty-four single nucleotide polymorphisms (SNPs) of 17 genes in glycolytic pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgical resection. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 44 SNPs investigated, four SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, PFKP rs1132173C > T, PDK2 rs3785921G > A) were significantly associated with survival outcomes in multivariate analyses...
October 21, 2016: Scientific Reports
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