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https://www.readbyqxmd.com/read/29471477/feasibility-of-smartphone-application-and-social-media-intervention-on-breast-cancer-survivors-health-outcomes
#1
Zachary Pope, Jung Eun Lee, Nan Zeng, Hee Yun Lee, Zan Gao
Breast cancer survivors are at risk for poor health, with physical activity a possible treatment. Little research has examined how technology might promote breast cancer survivor physical activity or health. The aim of this study is to investigate the feasibility of employing a commercially available mobile health application- and social media-based health education intervention to improve breast cancer survivor physical activity or health.Ten breast cancer survivors (X̅ age = 45.80 ± 10.23 years; X̅ weight = 79...
February 17, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29471428/cognitive-behavioural-therapy-for-fear-of-falling-and-balance-among-older-people-a-systematic-review-and-meta-analysis
#2
Tai-Wa Liu, Gabriel Y F Ng, Raymond C K Chung, Shamay S M Ng
Background: fear of falling is prevalent among older people and associated with various health outcomes. A growing number of studies have examined the effects of interventions designed to reduce the fear of falling and improve balance among older people, yet our current understanding is restricted to physiological interventions. Psychological interventions such as cognitive behavioural therapy (CBT) have not been reviewed and meta-analysed. Objective: to perform a systematic review and meta-analysis evaluating the effects of CBT on reducing fear of falling and enhancing balance in community-dwelling older people...
February 20, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29471296/ambulatory-assessment-of-borderline-personality-disorder
#3
Timothy J Trull
Ambulatory assessment (AA) is an important tool that promises to minimize retrospective biases while gathering ecologically valid data, including self-reports, physiological or biological data, and observed behavior, for example, from daily life experiences. AA is well suited for studying borderline personality disorder (BPD) because it can measure moods and emotion (as well as dynamic mood processes, mood changes, and mood instability), problematic behaviors (including interpersonal conflicts, addictive behaviors, binge and purge episodes, and motoric activity), and problematic cognitions/expectancies/urges (e...
February 22, 2018: Psychopathology
https://www.readbyqxmd.com/read/29471293/neonatal-stress-has-a-long-lasting-sex-dependent-effect-on-anxiety-like-behavior-and-neuronal-morphology-in-the-prefrontal-cortex-and-hippocampus
#4
Silvana Regina de Melo, Caren Tatiane de David Antoniazzi, Shakhawat Hossain, Bryan Kolb
The long-lasting effects of early stress on brain development have been well studied. Recent evidence indicates that males and females respond differently to the same stressor. We examined the chronic effects of daily maternal separation (MS) on behavior and cerebral morphology in both male and female rats. Cognitive and anxiety-like behaviors were evaluated, and neuroplastic changes in 2 subregions of the prefrontal cortex (dorsal agranular insular cortex [AID] and cingulate cortex [Cg3]) and hippocampus (CA1 and dentate gyrus) were measured in adult male and female rats...
February 22, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29471185/the-attention-training-technique-improves-children-s-ability-to-delay-gratification-a-controlled-comparison-with-progressive-relaxation
#5
Joanne Murray, Helen Scott, Claire Connolly, Adrian Wells
The ability to delay gratification at a young age is a predictor of psychological, cognitive, health, and academic later-life outcomes. This study aimed to extend earlier research and explore whether a metacognitive intervention, Wells' (1990) Attention Training Technique (ATT), could improve young children's ability to delay gratification compared to an active-control (Progressive Muscle Relaxation: PMR), and no-intervention group. One hundred and one children aged 5-6 years old were recruited from schools...
February 15, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29471099/the-dynamics-of-error-processing-in-the-human-brain-as-reflected-by-high-gamma-activity-in-noninvasive-and-intracranial-eeg
#6
Martin Völker, Lukas D J Fiederer, Sofie Berberich, Jiří Hammer, Joos Behncke, Pavel Kršek, Martin Tomášek, Petr Marusič, Peter C Reinacher, Volker A Coenen, Moritz Helias, Andreas Schulze-Bonhage, Wolfram Burgard, Tonio Ball
Error detection in motor behavior is a fundamental cognitive function heavily relying on cortical information processing. Neural activity in the high-gamma frequency band (HGB) closely reflects such local cortical processing, but little is known about its role in error processing, particularly in the healthy human brain. Here we characterize the error-related response of the human brain based on data obtained with noninvasive EEG optimized for HGB mapping in 31 healthy subjects (15 females, 16 males), and additional intracranial EEG data from 9 epilepsy patients (4 females, 5 males)...
February 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29471098/the-role-of-effective-connectivity-between-the-task-positive-and-task-negative-network-for-evidence-gathering-evidence-gathering-and-connectivity
#7
Christina Andreou, Saskia Steinmann, Katharina Kolbeck, Jonas Rauh, Gregor Leicht, Steffen Moritz, Christoph Mulert
Reports linking a 'jumping-to-conclusions' bias to delusions have led to growing interest in the neurobiological correlates of probabilistic reasoning. Several brain areas have been implicated in probabilistic reasoning; however, findings are difficult to integrate into a coherent account. The present study aimed to provide additional evidence by investigating, for the first time, effective connectivity among brain areas involved in different stages of evidence gathering. We investigated evidence gathering in 25 healthy individuals using fMRI and a new paradigm (Box Task) designed such as to minimize the effects of cognitive effort and reward processing...
February 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29471053/morphological-and-functional-evidence-of-increased-excitatory-signaling-in-the-prelimbic-cortex-during-ethanol-withdrawal
#8
Florence P Varodayan, Harpreet Sidhu, Max Kreifeldt, Marisa Roberto, Candice Contet
Excessive alcohol consumption in humans induces deficits in decision making and emotional processing, which indicates a dysfunction of the prefrontal cortex (PFC). The present study aimed to determine the impact of chronic intermittent ethanol (CIE) inhalation on mouse medial PFC pyramidal neurons. Data were collected 6-8 days into withdrawal from 7 weeks of CIE exposure, a time point when mice exhibit behavioral symptoms of withdrawal. We found that spine maturity in prelimbic (PL) layer 2/3 neurons was increased, while dendritic spines in PL layer 5 neurons or infralimbic (IL) neurons were not affected...
February 19, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29470982/rip3-deficiency-protects-against-traumatic-brain-injury-tbi-through-suppressing-oxidative-stress-inflammation-and-apoptosis-dependent-on-ampk-pathway
#9
Zai-Ming Liu, Qian-Xue Chen, Zhi-Biao Chen, Dao-Feng Tian, Ming-Chang Li, Jun-Min Wang, Long Wang, Bao-Hui Liu, Shen-Qi Zhang, Fei Li, Hui Ye, Long Zhou
Traumatic brain injury (TBI) is a leading cause of disability and mortality in young adults worldwide. The pathophysiology is not fully understood. Programmed necrosis (necroptosis) is a newly identified mechanism of cell death combining features of both apoptosis and necrosis. Receptor-interacting protein 3 (RIP3) plays an important role in programmed necrosis. However, the effect of RIP3-related pathway in TBI is little to be known. We attempted to explore the significance of RIP3 in regulating TBI in vivo...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29470796/peers-influence-adolescent-reward-processing-but-not-response-inhibition
#10
Ashley R Smith, Gail M Rosenbaum, Morgan A Botdorf, Laurence Steinberg, Jason M Chein
Most adolescent risk taking occurs in the presence of peers. Prior research suggests that peers alter adolescents' decision making by increasing reward sensitivity and the engagement of regions involved in the processing of rewards, primarily the striatum. However, the potential influence of peers on the capacity for impulse control, and the associated recruitment of the brain's control circuitry, has not yet been adequately examined. In the current study, adolescents underwent functional neuroimaging while they completed interleaved rounds of risk-taking and response-inhibition tasks...
February 22, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29470766/haloperidol-attenuates-methylphenidate-and-modafinil-induced-behavioural-sensitization-and-cognitive-enhancement
#11
Nausheen Alam, Kulsoom Choudhary
Previous studies have demonstrated that repeated psychostimulant administration produces behavioural sensitization and cognitive tolerance. Brain dopaminergic system and the involvement of dopamine D2 -receptors are considered to be important in psychostimulant-induced sensitization. Study designed to compared the motor activity by using familiar and novel enviroments and cognitive effects by water maze and passive avoidance test after long term administration of methylphenidate(at the dose 0.6 mg/kg/day, 2...
February 22, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29470291/recurrent-abdominal-pain-in-children-summary-evidence-from-3-systematic-reviews-of-treatment-effectiveness
#12
Rebecca A Abbott, Alice E Martin, Tamsin V Newlove-Delgado, Alison Bethel, Rebecca S Whear, Jo Thompson Coon, Stuart Logan
OBJECTIVES: Between 4% and 25% of school-aged children complain of recurrent abdominal pain (RAP) severe enough to interfere with their daily activities. METHODS: We carried out a systematic review of randomised controlled trials (RCTs) in eleven databases and 2 trials registries from inception to June 2016. An update search was run in November 2017. All screening was performed by 2 independent reviewers. Included studies were appraised using the Cochrane risk of bias tool and the evidence assessed using GRADE...
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29468740/neuroprotective-effects-of-20-s-protopanaxatriol-ppt-on-scopolamine-induced-cognitive-deficits-in-mice
#13
Cong Lu, Jingwei Lv, Liming Dong, Ning Jiang, Yan Wang, Qiong Wang, Yinghui Li, Shanguang Chen, Bei Fan, Fengzhong Wang, Xinmin Liu
20(S)-protopanaxatriol (PPT), one of the ginsenosides from Panax ginseng, has been reported to have neuroprotective effects and to improve memory. The present study was designed to investigate the protective effect of PPT on scopolamine-induced cognitive deficits in mice. Male Institute of Cancer Research mice were pretreated with 2 different doses of PPT (20 and 40 μmol/kg) for 27 days by intraperitoneal injection, and scopolamine (0.75 mg/kg) was injected intraperitoneally for 9 days to induce memory impairment...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29468294/behavioral-phenotyping-and-dopamine-dynamics-in-mice-with-conditional-deletion-of-the-glutamate-transporter-glt-1-in-neurons-resistance-to-the-acute-locomotor-effects-of-amphetamine
#14
Kathryn D Fischer, Alex C W Houston, Rajeev I Desai, Michelle R Doyle, Jack Bergman, Maha Mian, Rebekah Mannix, David L Sulzer, Se Joon Choi, Eugene V Mosharov, Nathaniel W Hodgson, Anita Bechtholt, Klaus A Miczek, Paul A Rosenberg
RATIONALE: GLT-1 is the major glutamate transporter in the brain and is expressed predominantly in astrocytes but is also present in excitatory axon terminals. To understand the functional significance of GLT-1 expressed in neurons, we generated a conditional GLT-1 knockout mouse and inactivated GLT-1 in neurons using Cre-recombinase expressed under the synapsin 1 promoter, (synGLT-1 KO). OBJECTIVES: Abnormalities of glutamate homeostasis have been shown to affect hippocampal-related behaviors including learning and memory as well as responses to drugs of abuse...
February 22, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29468084/a-development-study-and-randomised-feasibility-trial-of-a-tailored-intervention-to-improve-activity-and-reduce-falls-in-older-adults-with-mild-cognitive-impairment-and-mild-dementia
#15
Rowan H Harwood, Veronika van der Wardt, Sarah E Goldberg, Fiona Kearney, Pip Logan, Vicky Hood-Moore, Vicky Booth, Jennie E Hancox, Tahir Masud, Zoe Hoare, Andrew Brand, Rhiannon Tudor Edwards, Carys Jones, Roshan das Nair, Kristian Pollock, Maureen Godfrey, John R F Gladman, Kavita Vedhara, Helen Smith, Martin Orrell
Background: People with dementia progressively lose abilities and are prone to falling. Exercise- and activity-based interventions hold the prospect of increasing abilities, reducing falls, and slowing decline in cognition. Current falls prevention approaches are poorly suited to people with dementia, however, and are of uncertain effectiveness. We used multiple sources, and a co-production approach, to develop a new intervention, which we will evaluate in a feasibility randomised controlled trial (RCT), with embedded adherence, process and economic analyses...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29467709/delayed-latency-of-postural-muscles-of-individuals-with-intellectual-disabilities
#16
J Walter Tolentino-Castro, Andreas Mühlbeier, Luis Mochizuki, Heiko Wagner
Individuals with intellectual disabilities (ID) (50 < IQ < 79) show impaired motor and postural control, these impairments are highly related to falls and injuries. Recent studies demonstrated these impairments are related with fine and gross motor development, which are more strongly associated with cognition, and consequently language for individuals with ID than for without ID. Despite these studies, little is known about the structure and functioning of this population's spinal cord, which is highly involved in postural control...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29467706/opening-the-implicit-leadership-theories-black-box-an-experimental-approach-with-conjoint-analysis
#17
Gustavo M Tavares, Filipe Sobral, Rafael Goldszmidt, Felipe Araújo
Although research on implicit leadership theories (ILTs) has concentrated on determining which attributes define a leadership prototype, little attention has been paid to testing the relative importance of each of these attributes for individuals' leadership perceptions. Building on socio-cognitive theories of impression processes, we experimentally explore the formation of leadership perceptions based on the recognition of six key attributes in a series of three experimental studies comprising 566 US-based participants recruited online via Amazon Mechanical Turk...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29467618/reevaluation-of-fmr1-hypermethylation-timing-in-fragile-x-syndrome
#18
REVIEW
Hagar Mor-Shaked, Rachel Eiges
Fragile X syndrome (FXS) is one of the most common heritable forms of cognitive impairment. It results from a fragile X mental retardation protein (FMRP) protein deficiency caused by a CGG repeat expansion in the 5'-UTR of the X-linked FMR1 gene. Whereas in most individuals the number of CGGs is steady and ranges between 5 and 44 units, in patients it becomes extensively unstable and expands to a length exceeding 200 repeats (full mutation). Interestingly, this disease is exclusively transmitted by mothers who carry a premutation allele (55-200 CGG repeats)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29467577/human-immunodeficiency-virus-in-the-brain-culprit-or-facilitator
#19
REVIEW
Luminita Ene
Introduction: Human immunodeficiency virus (HIV) enters the brain early, where it can persist, evolve, and become compartmentalized. Central nervous system (CNS) disease can be attributed to HIV alone or to the complex interplay between the virus and other neurotropic pathogens. Aim: The current review aims to describe the direct impact of HIV on the brain as well as its relationship with other pathogens from a practitioner's perspective, to provide a general clinical overview, brief workup, and, whenever possible, treatment guidance...
2018: Infectious Diseases
https://www.readbyqxmd.com/read/29467572/prevalence-of-geriatric-syndromes-among-people-aged-65-years-and-older-at-four-community-clinics-in-moscow
#20
Olga N Tkacheva, Nadezda K Runikhina, Valentina S Ostapenko, Natalia V Sharashkina, Elen A Mkhitaryan, Julia S Onuchina, Sergei N Lysenkov, Nikolai N Yakhno, Yan Press
Background: Geriatric syndromes (GSs) are common in older adults and have a significant effect on their quality of life, disability, and use of health care resources. Few studies have assessed the prevalence of GSs in Russia. The aim of this study is to assess the prevalence of GSs among older adults living in the community in Moscow. Methods: A cross-sectional study was conducted in four community clinics in Moscow. A total of 1,220 patients completed a screening questionnaire, and 356 of them also underwent a comprehensive geriatric assessment (CGA)...
2018: Clinical Interventions in Aging
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