Tiantian Hua, Houyou Fan, Yunyun Duan, Decai Tian, Zhenpeng Chen, Xiaolu Xu, Yutong Bai, Yuna Li, Ningnannan Zhang, Jie Sun, Haiqing Li, Yuxin Li, Yongmei Li, Chun Zeng, Xuemei Han, Fuqing Zhou, Muhua Huang, Siyao Xu, Ying Jin, Hongfang Li, Zhizheng Zhuo, Xinghu Zhang, Yaou Liu
BACKGROUND: Spinal cord and brain atrophy are common in neuromyelitis optica spectrum disorder (NMOSD) and relapsing-remitting multiple sclerosis (RRMS) but harbor distinct patterns accounting for disability and cognitive impairment. METHODS: This study included 209 NMOSD and 304 RRMS patients and 436 healthy controls. Non-negative matrix factorization was used to parse differences in spinal cord and brain atrophy at subject level into distinct patterns based on structural MRI...
April 1, 2024: Journal of Neurology