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https://www.readbyqxmd.com/read/28931923/mllt10-knockout-mouse-model-reveals-critical-role-of-af10-dependent-h3k79-methylation-in-midfacial-development
#1
Honami Ogoh, Kazutsune Yamagata, Tomomi Nakao, Lisa L Sandell, Ayaka Yamamoto, Aiko Yamashita, Naomi Tanga, Mai Suzuki, Takaya Abe, Issay Kitabayashi, Toshio Watanabe, Daisuke Sakai
Epigenetic regulation is required to ensure the precise spatial and temporal pattern of gene expression that is necessary for embryonic development. Although the roles of some epigenetic modifications in embryonic development have been investigated in depth, the role of methylation at lysine 79 (H3K79me) is poorly understood. Dot1L, a unique methyltransferase for H3K79, forms complexes with distinct sets of co-factors. To further understand the role of H3K79me in embryogenesis, we generated a mouse knockout of Mllt10, the gene encoding Af10, one Dot1L complex co-factor...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931884/amplitude-of-travelling-front-as-inferred-from-14-c-predicts-levels-of-genetic-admixture-among-european-early-farmers
#2
Fabio Silva, Marc Vander Linden
Large radiocarbon datasets have been analysed statistically to identify, on the one hand, the dynamics and tempo of dispersal processes and, on the other, demographic change. This is particularly true for the spread of farming practices in Neolithic Europe. Here we combine the two approaches and apply them to a new, extensive dataset of 14,535 radiocarbon dates for the Mesolithic and Neolithic periods across the Near East and Europe. The results indicate three distinct demographic regimes: one observed in or around the centre of farming innovation and involving a boost in carrying capacity; a second appearing in regions where Mesolithic populations were well established; and a third corresponding to large-scale migrations into previously essentially unoccupied territories, where the travelling front is readily identified...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931803/laminar-differences-in-decision-related-neural-activity-in-dorsal-premotor-cortex
#3
Chandramouli Chandrasekaran, Diogo Peixoto, William T Newsome, Krishna V Shenoy
Dorsal premotor cortex is implicated in somatomotor decisions. However, we do not understand the temporal patterns and laminar organization of decision-related firing rates in dorsal premotor cortex. We recorded neurons from dorsal premotor cortex of monkeys performing a visual discrimination task with reaches as the behavioral report. We show that these neurons can be organized along a bidirectional visuomotor continuum based on task-related firing rates. "Increased" neurons at one end of the continuum increased their firing rates ~150 ms after stimulus onset and these firing rates covaried systematically with choice, stimulus difficulty, and reaction time-characteristics of a candidate decision variable...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28931442/employment-status-and-temporal-patterns-of-energy-intake-nutrition-and-health-survey-in-taiwan-2005-2008
#4
Chun-An Chau, Wen-Harn Pan, Hsin-Jen Chen
OBJECTIVE: To (i) identify the major temporal patterns of energy intake among adults; (ii) examine the association between employment status and the patterns; and (iii) examine the association between dietary quality and the patterns. DESIGN: Secondary analysis based on the cross-sectional population-based nutrition survey in Taiwan, 2005-2008. Based on energy intake levels at six time intervals of a day derived from 24 h recall data, we applied cluster analysis to identify major temporal patterns of energy intake...
September 21, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28930946/evaluating-the-traditional-day-and-night-shift-in-an-acute-care-surgery-fellowship-is-the-swing-shift-a-better-choice
#5
Paul J Chestovich, Christopher F McNicoll, Nichole K Ingalls, Deborah A Kuhls, Douglas R Fraser, Shawna L Morrissey, John J Fildes
BACKGROUND: Fellowship trainees in Acute Care Surgery require experience in the management of complex and operative trauma cases. Trauma center staffing usually follows standard 12 or 24 hour shifts, with resident and fellow trainees following a similar schedule. Although trauma admissions can be generally unpredictable, we analyzed temporal trends of trauma patient arrival times to determine the best time frame to maximize trainee experience during each day. METHODS: We reviewed ten years (2007-2016) of trauma registry data for blunt and penetrating trauma activations...
September 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28923977/prepatterning-by-rhogefs-governs-rho-gtpase-spatiotemporal-dynamics-during-wound-repair
#6
Mitsutoshi Nakamura, Jeffrey M Verboon, Susan M Parkhurst
Like tissues, single cells are subjected to continual stresses and damage. As such, cells have a robust wound repair mechanism comprised of dynamic membrane resealing and cortical cytoskeletal remodeling. One group of proteins, the Rho family of small guanosine triphosphatases (GTPases), is critical for this actin and myosin cytoskeletal response in which they form distinct dynamic spatial and temporal patterns/arrays surrounding the wound. A key mechanistic question, then, is how these GTPase arrays are formed...
September 18, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28922802/succession-of-arbuscular-mycorrhizal-fungi-along-a-52-year-agricultural-recultivation-chronosequence
#7
Julien Roy, Rüdiger Reichel, Nicolas Brüggemann, Stefan Hempel, Matthias C Rillig
Arbuscular mycorrhizal (AM) fungi provide a range of functions in natural and managed ecosystems. However, the trajectory of AM fungal diversity after land degradation is poorly known. We studied the succession of AM fungi along an agricultural recultivation chronosequence after open-cast mining near Cologne, Germany. We used high-throughput sequencing of the large-subunit ribosomal RNA genes to characterize the soil AM fungal communities of 10 agricultural fields spanning 52 years of recultivation. During three years, soils are recultivated with a legume, and then converted to agriculture to be later returned to local farmers implementing conventional agriculture...
September 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28922648/a-theoretical-and-empirical-modeling-of-anxiety-integrated-with-rdoc-and-temporal-dynamics
#8
Brandon Frank, Nicholas C Jacobson, Landon Hurley, Dean McKay
The newly launched Research Domain Criteria (RDoC) emphasize specific mechanisms over diagnostic categories of psychopathology. In our view, RDoC provides a useful heuristic for mental health disorders, but does not capture the complexity of psychological data when proposed mechanisms are viewed as static entities. However, temporal and complex system dynamics may advance RDoC's utility. By investigating temporal patterns within trajectories and the interaction of complex networks, we propose that dynamic modeling provides comprehensive methods with which to investigate the etiopathology and maintenance of mental health disorders...
September 8, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28921742/processing-of-temporally-patterned-sounds-in-the-auditory-cortex-of-seba-s-short-tailed-bat-carollia-perspicillata
#9
Lisa M Martin, Francisco García-Rosales, M Jerome Beetz, Julio C Hechavarría
This article presents a characterization of cortical responses to artificial and natural temporally-patterned sounds in the bat species Carollia perspicillata, a species that produces vocalizations at rates above 50 Hz. Multi-unit activity was recorded in three different experiments. In the first experiment, amplitude modulated (AM) pure tones were used as stimuli to drive auditory cortex (AC) units. AC units of both ketamine-anesthetized and awake bats could lock their spikes to every cycle of the stimulus modulation envelope, but only if the modulation frequency was below 22 Hz...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28921653/visualization-of-temporal-patterns-in-patient-record-data
#10
Catherine Plaisant
Visualization contributes to a variety of tasks, from reviewing individual patient records to helping researchers assess data quality, find patients of interest, review temporal patterns and anomalies or understand differences between cohorts. We review some of visualization techniques developed at the University of Maryland. This article is protected by copyright. All rights reserved.
September 16, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28919257/seizures-by-the-clock-temporal-patterns-of-psychogenic-nonepileptic-seizures
#11
Udaya Seneviratne, Erica Minato, Eldho Paul
We hypothesized that (1) the occurrence of psychogenic nonepileptic seizures (PNES) is modulated by the interaction between the 24-hour clock and the sleep-wake cycle and (2) the pattern of modulation in PNES differs from epileptic seizures (ES). We sought to test our hypotheses in a cohort of patients diagnosed with PNES or ES in the setting of an epilepsy monitoring unit (EMU). We retrospectively reviewed consecutive video-EEG (VEEG) recordings of patients who underwent monitoring at the EMU of a tertiary hospital...
September 11, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28918949/old-growth-fishes-become-scarce-under-fishing
#12
Lewis A K Barnett, Trevor A Branch, R Anthony Ranasinghe, Timothy E Essington
Researchers have long recognized the importance of ecological differences at the species level in structuring natural communities yet until recently have often overlooked the influence of intraspecific trait variation, which can profoundly alter community dynamics [1]. Human extraction of living resources can reduce intraspecific trait variation by, for example, causing truncation of age and size structure of populations, where numbers of older individuals decline far more with exploitation than younger individuals...
September 7, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28916613/time-intensive-transcriptomics-reveal-temporal-patterns-in-the-jasmonic-acid-gene-regulatory-network
#13
Sonali Roy
No abstract text is available yet for this article.
September 15, 2017: Plant Cell
https://www.readbyqxmd.com/read/28915455/estimation-of-water-consumption-for-ecosystems-based-on-vegetation-interfaces-processes-model-a-case-study-of-the-aksu-river-basin-northwest-china
#14
Peng Yang, Jun Xia, Chesheng Zhan, Xingguo Mo, Xuejuan Chen, Shi Hu, Jie Chen
Based on the Moderate Resolution Imaging Spectroradiometer (MODIS) - Normalized Difference Vegetation Index (NDVI), the Vegetation Interfaces Processes (VIP) model simulated the spatio-temporal patterns of actual evapotranspiration (ET) and the water consumption of different ecosystems in the Aksu River Basin, Northwest China between 2000 and 2015. The results revealed that: (1) the applicability of the VIP model was confirmed, with good agreement (R(2)=0.79, P<0.05) between the VIP-ET and water balance model (WB)-ET in the Aksu River Basin; (2)arable land showed the highest annual actual ET per unit pixel (362...
September 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28913175/regulation-of-endoplasmic-reticulum-mitochondria-ca-2-transfer-and-its-importance-for-anti-cancer-therapies
#15
REVIEW
Gaia Pedriali, Alessandro Rimessi, Luigi Sbano, Carlotta Giorgi, Mariusz R Wieckowski, Maurizio Previati, Paolo Pinton
Inter-organelle membrane contact sites are emerging as major sites for the regulation of intracellular Ca(2+) concentration and distribution. Here, extracellular stimuli operate on a wide array of channels, pumps, and ion exchangers to redistribute intracellular Ca(2+) among several compartments. The resulting highly defined spatial and temporal patterns of Ca(2+) movement can be used to elicit specific cellular responses, including cell proliferation, migration, or death. Plasma membrane (PM) also can directly contact mitochondria and endoplasmic reticulum (ER) through caveolae, small invaginations of the PM that ensure inter-organelle contacts, and can contribute to the regulation of numerous cellular functions through scaffolding proteins such as caveolins...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28912588/lipopolysaccharide-initiated-persistent-rhinitis-causes-gliosis-and-synaptic-loss-in-the-olfactory-bulb
#16
Sanae Hasegawa-Ishii, Atsuyoshi Shimada, Fumiaki Imamura
The olfactory mucosa (OM) is exposed to environmental agents and therefore vulnerable to inflammation. To examine the effects of environmental toxin-initiated OM inflammation on the olfactory bulb (OB), we induced persistent rhinitis in mice and analyzed the spatial and temporal patterns of histopathological changes in the OM and OB. Mice received unilateral intranasal administration of lipopolysaccharide (LPS) or saline three times per week, and were immunohistologically analyzed at 1, 3, 7, 14 and 21 days after the first administration...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910378/neuroinflammation-myelin-and-behavior-temporal-patterns-following-mild-traumatic-brain-injury-in-mice
#17
Toufik Taib, Claire Leconte, Juliette Van Steenwinckel, Angelo H Cho, Bruno Palmier, Egle Torsello, Rene Lai Kuen, Somfieme Onyeomah, Karine Ecomard, Chiara Benedetto, Bérard Coqueran, Anne-Catherine Novak, Edwige Deou, Michel Plotkine, Pierre Gressens, Catherine Marchand-Leroux, Valérie C Besson
Traumatic brain injury (TBI) results in white matter injury (WMI) that is associated with neurological deficits. Neuroinflammation originating from microglial activation may participate in WMI and associated disorders. To date, there is little information on the time courses of these events after mild TBI. Therefore we investigated (i) neuroinflammation, (ii) WMI and (iii) behavioral disorders between 6 hours and 3 months after mild TBI. For that purpose, we used experimental mild TBI in mice induced by a controlled cortical impact...
2017: PloS One
https://www.readbyqxmd.com/read/28904381/sexual-size-dimorphism-modulates-the-trade-off-between-exploiting-food-and-wind-resources-in-a-large-avian-scavenger
#18
Pablo A E Alarcón, Juan M Morales, José A Donázar, José A Sánchez-Zapata, Fernando Hiraldo, Sergio A Lambertucci
Animals are expected to synchronize activity routines with the temporal patterns at which resources appear in nature. Accordingly, species that depend on resources showing temporally mismatched patterns should be expected to schedule routines that balance the chances of exploiting each of them. Large avian scavengers depend on carcasses which are more likely available early in the morning, but they also depend on wind resources (i.e. uplifts) to subside flight which are stronger in afternoon hours. To understand how these birds deal with this potential trade-off, we studied the daily routines of GPS-tagged individuals of the world's largest terrestrial soaring scavenger, the Andean condor (Vultur gryphus)...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902915/social-interactions-between-live-and-artificial-weakly-electric-fish-electrocommunication-and-locomotor-behavior-of-mormyrus-rume-proboscirostris-towards-a-mobile-dummy-fish
#19
Martin Worm, Frank Kirschbaum, Gerhard von der Emde
Mormyrid weakly electric fish produce short, pulse-type electric organ discharges for actively probing their environment and to communicate with conspecifics. Animals emit sequences of pulse-trains that vary in overall frequency and temporal patterning and can lead to time-locked interactions with the discharge activity of other individuals. Both active electrolocation and electrocommunication are additionally accompanied by stereotypical locomotor patterns. However, the concrete roles of electrical and locomotor patterns during social interactions in mormyrids are not well understood...
2017: PloS One
https://www.readbyqxmd.com/read/28899597/playing-well-with-others-extrinsic-cues-regulate-neural-progenitor-temporal-identity-to-generate-neuronal-diversity
#20
REVIEW
Mubarak Hussain Syed, Brandon Mark, Chris Q Doe
During neurogenesis, vertebrate and Drosophila progenitors change over time as they generate a diverse population of neurons and glia. Vertebrate neural progenitors have long been known to use both progenitor-intrinsic and progenitor-extrinsic cues to regulate temporal patterning. In contrast, virtually all temporal patterning mechanisms discovered in Drosophila neural progenitors (neuroblasts) involve progenitor-intrinsic temporal transcription factor cascades. Recent results, however, have revealed several extrinsic pathways that regulate Drosophila neuroblast temporal patterning: nutritional cues regulate the timing of neuroblast proliferation/quiescence and a steroid hormone cue that is required for temporal transcription factor expression...
September 9, 2017: Trends in Genetics: TIG
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